TY - GEN A1 - Riaño-Pachón, Diego Mauricio A1 - Kleessen, Sabrina A1 - Neigenfind, Jost A1 - Durek, Pawel A1 - Weber, Elke A1 - Engelsberger, Wolfgang R. A1 - Walther, Dirk A1 - Selbig, Joachim A1 - Schulze, Waltraud X. A1 - Kersten, Birgit T1 - Proteome-wide survey of phosphorylation patterns affected by nuclear DNA polymorphisms in Arabidopsis thaliana T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background: Protein phosphorylation is an important post-translational modification influencing many aspects of dynamic cellular behavior. Site-specific phosphorylation of amino acid residues serine, threonine, and tyrosine can have profound effects on protein structure, activity, stability, and interaction with other biomolecules. Phosphorylation sites can be affected in diverse ways in members of any species, one such way is through single nucleotide polymorphisms (SNPs). The availability of large numbers of experimentally identified phosphorylation sites, and of natural variation datasets in Arabidopsis thaliana prompted us to analyze the effect of non-synonymous SNPs (nsSNPs) onto phosphorylation sites. Results: From the analyses of 7,178 experimentally identified phosphorylation sites we found that: (i) Proteins with multiple phosphorylation sites occur more often than expected by chance. (ii) Phosphorylation hotspots show a preference to be located outside conserved domains. (iii) nsSNPs affected experimental phosphorylation sites as much as the corresponding non-phosphorylated amino acid residues. (iv) Losses of experimental phosphorylation sites by nsSNPs were identified in 86 A. thaliana proteins, among them receptor proteins were overrepresented. These results were confirmed by similar analyses of predicted phosphorylation sites in A. thaliana. In addition, predicted threonine phosphorylation sites showed a significant enrichment of nsSNPs towards asparagines and a significant depletion of the synonymous substitution. Proteins in which predicted phosphorylation sites were affected by nsSNPs (loss and gain), were determined to be mainly receptor proteins, stress response proteins and proteins involved in nucleotide and protein binding. Proteins involved in metabolism, catalytic activity and biosynthesis were less affected. Conclusions: We analyzed more than 7,100 experimentally identified phosphorylation sites in almost 4,300 protein-coding loci in silico, thus constituting the largest phosphoproteomics dataset for A. thaliana available to date. Our findings suggest a relatively high variability in the presence or absence of phosphorylation sites between different natural accessions in receptor and other proteins involved in signal transduction. Elucidating the effect of phosphorylation sites affected by nsSNPs on adaptive responses represents an exciting research goal for the future. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1328 KW - Gene Ontology KW - Phosphorylation Site KW - phosphorylated amino acid KW - slim term KW - single nucleotide polymorphism mapping Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431181 SN - 1866-8372 IS - 1328 ER - TY - GEN A1 - Mooij, Wolf M. A1 - Trolle, Dennis A1 - Jeppesen, Erik A1 - Arhonditsis, George B. A1 - Belolipetsky, Pavel V. A1 - Chitamwebwa, Deonatus B. R. A1 - Degermendzhy, Andrey G. A1 - DeAngelis, Donald L. A1 - Domis, Lisette Nicole de Senerpont A1 - Downing, Andrea S. A1 - Elliott, J. Alex A1 - Fragoso Jr., Carlos Ruberto A1 - Gaedke, Ursula A1 - Genova, Svetlana N. A1 - Gulati, Ramesh D. A1 - Håkanson, Lars A1 - Hamilton, David P. A1 - Hipsey, Matthew R. A1 - ‘t Hoen, Jochem A1 - Hülsmann, Stephan A1 - Los, F. Hans A1 - Makler-Pick, Vardit A1 - Petzoldt, Thomas A1 - Prokopkin, Igor G. A1 - Rinke, Karsten A1 - Schep, Sebastiaan A. A1 - Tominaga, Koji A1 - Van Dam, Anne A. A1 - Van Nes, Egbert H. A1 - Wells, Scott A. A1 - Janse, Jan H. T1 - Challenges and opportunities for integrating lake ecosystem modelling approaches T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - A large number and wide variety of lake ecosystem models have been developed and published during the past four decades. We identify two challenges for making further progress in this field. One such challenge is to avoid developing more models largely following the concept of others ('reinventing the wheel'). The other challenge is to avoid focusing on only one type of model, while ignoring new and diverse approaches that have become available ('having tunnel vision'). In this paper, we aim at improving the awareness of existing models and knowledge of concurrent approaches in lake ecosystem modelling, without covering all possible model tools and avenues. First, we present a broad variety of modelling approaches. To illustrate these approaches, we give brief descriptions of rather arbitrarily selected sets of specific models. We deal with static models (steady state and regression models), complex dynamic models (CAEDYM, CE-QUAL-W2, Delft 3D-ECO, LakeMab, LakeWeb, MyLake, PCLake, PROTECH, SALMO), structurally dynamic models and minimal dynamic models. We also discuss a group of approaches that could all be classified as individual based: super-individual models (Piscator, Charisma), physiologically structured models, stage-structured models and traitbased models. We briefly mention genetic algorithms, neural networks, Kalman filters and fuzzy logic. Thereafter, we zoom in, as an in-depth example, on the multi-decadal development and application of the lake ecosystem model PCLake and related models (PCLake Metamodel, Lake Shira Model, IPH-TRIM3D-PCLake). In the discussion, we argue that while the historical development of each approach and model is understandable given its 'leading principle', there are many opportunities for combining approaches. We take the point of view that a single 'right' approach does not exist and should not be strived for. Instead, multiple modelling approaches, applied concurrently to a given problem, can help develop an integrative view on the functioning of lake ecosystems. We end with a set of specific recommendations that may be of help in the further development of lake ecosystem models. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1326 KW - aquatic KW - food web dynamics KW - plankton KW - nutrients KW - spatial KW - lake KW - freshwater KW - marine KW - community KW - population KW - hydrology KW - eutrophication KW - global change KW - climate warming KW - fisheries KW - biodiversity KW - management KW - mitigation KW - adaptive processes KW - non-linear dynamics KW - analysis KW - bifurcation KW - understanding KW - prediction KW - model limitations KW - model integration Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-429839 SN - 1866-8372 IS - 1326 ER - TY - GEN A1 - Margaria, Tiziana A1 - Steffen, Bernhard A1 - Kubczak, Christian T1 - Evolution support in heterogeneous service-oriented landscapes T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - We present an approach that provides automatic or semi-automatic support for evolution and change management in heterogeneous legacy landscapes where (1) legacy heterogeneous, possibly distributed platforms are integrated in a service oriented fashion, (2) the coordination of functionality is provided at the service level, through orchestration, (3) compliance and correctness are provided through policies and business rules, (4) evolution and correctness-by-design are supported by the eXtreme Model Driven Development paradigm (XMDD) offered by the jABC (Margaria and Steffen in Annu. Rev. Commun. 57, 2004)—the model-driven service oriented development platform we use here for integration, design, evolution, and governance. The artifacts are here semantically enriched, so that automatic synthesis plugins can field the vision of Enterprise Physics: knowledge driven business process development for the end user. We demonstrate this vision along a concrete case study that became over the past three years a benchmark for Semantic Web Service discovery and mediation. We enhance the Mediation Scenario of the Semantic Web Service Challenge along the 2 central evolution paradigms that occur in practice: (a) Platform migration: platform substitution of a legacy system by an ERP system and (b) Backend extension: extension of the legacy Customer Relationship Management (CRM) and Order Management System (OMS) backends via an additional ERP layer. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 918 KW - evolving systems KW - semantic web services KW - service mediation KW - web services KW - SOA Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432405 SN - 1866-8372 IS - 918 ER - TY - GEN A1 - Weiße, Andrea Y. A1 - Middleton, Richard H. A1 - Huisinga, Wilhelm T1 - Quantifying uncertainty, variability and likelihood for ordinary differential equation models T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background In many applications, ordinary differential equation (ODE) models are subject to uncertainty or variability in initial conditions and parameters. Both, uncertainty and variability can be quantified in terms of a probability density function on the state and parameter space. Results The partial differential equation that describes the evolution of this probability density function has a form that is particularly amenable to application of the well-known method of characteristics. The value of the density at some point in time is directly accessible by the solution of the original ODE extended by a single extra dimension (for the value of the density). This leads to simple methods for studying uncertainty, variability and likelihood, with significant advantages over more traditional Monte Carlo and related approaches especially when studying regions with low probability. Conclusions While such approaches based on the method of characteristics are common practice in other disciplines, their advantages for the study of biological systems have so far remained unrecognized. Several examples illustrate performance and accuracy of the approach and its limitations. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 894 KW - ordinary differential equation KW - Unscented Kalman Filter KW - global sensitivity analysis KW - Ordinary Differential Equation model KW - joint normal distribution Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431340 SN - 1866-8372 IS - 894 ER - TY - GEN A1 - Breitenstein, Michael A1 - Hölzel, Ralph A1 - Bier, Frank Fabian T1 - Immobilization of different biomolecules by atomic force microscopy T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Background Micrometer resolution placement and immobilization of probe molecules is an important step in the preparation of biochips and a wide range of lab-on-chip systems. Most known methods for such a deposition of several different substances are costly and only suitable for a limited number of probes. In this article we present a flexible procedure for simultaneous spatially controlled immobilization of functional biomolecules by molecular ink lithography. Results For the bottom-up fabrication of surface bound nanostructures a universal method is presented that allows the immobilization of different types of biomolecules with micrometer resolution. A supporting surface is biotinylated and streptavidin molecules are deposited with an AFM (atomic force microscope) tip at distinct positions. Subsequent incubation with a biotinylated molecule species leads to binding only at these positions. After washing streptavidin is deposited a second time with the same AFM tip and then a second biotinylated molecule species is coupled by incubation. This procedure can be repeated several times. Here we show how to immobilize different types of biomolecules in an arbitrary arrangement whereas most common methods can deposit only one type of molecules. The presented method works on transparent as well as on opaque substrates. The spatial resolution is better than 400 nm and is limited only by the AFM's positional accuracy after repeated z-cycles since all steps are performed in situ without moving the supporting surface. The principle is demonstrated by hybridization to different immobilized DNA oligomers and was validated by fluorescence microscopy. Conclusions The immobilization of different types of biomolecules in high-density microarrays is a challenging task for biotechnology. The method presented here not only allows for the deposition of DNA at submicrometer resolution but also for proteins and other molecules of biological relevance that can be coupled to biotin. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 872 KW - Atomic Force Microscope KW - Immobilization KW - Cross Contamination KW - Roth GmbH KW - Microcontact Printing Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435075 SN - 1866-8372 IS - 872 ER - TY - GEN A1 - Repsilber, Dirk A1 - Kern, Sabine A1 - Telaar, Anna A1 - Walzl, Gerhard A1 - Black, Gillian F. A1 - Selbig, Joachim A1 - Parida, Shreemanta K. A1 - Kaufmann, Stefan H. E. A1 - Jacobsen, Marc T1 - Biomarker discovery in heterogeneous tissue samples BT - taking the in-silico deconfounding approach T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background: For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on estimation of gene expression signals for homogeneous cell populations, e.g. by applying micro-dissection, fluorescence activated cell sorting, or in-silico deconfounding. We studied feasibility and validity of a non-negative matrix decomposition algorithm using experimental gene expression data for blood and sorted cells from the same donor samples. Our objective was to optimize the algorithm regarding detection of differentially expressed genes and to enable its use for classification in the difficult scenario of reversely regulated genes. This would be of importance for the identification of candidate biomarkers in heterogeneous tissues. Results: Experimental data and simulation studies involving noise parameters estimated from these data revealed that for valid detection of differential gene expression, quantile normalization and use of non-log data are optimal. We demonstrate the feasibility of predicting proportions of constituting cell types from gene expression data of single samples, as a prerequisite for a deconfounding-based classification approach. Classification cross-validation errors with and without using deconfounding results are reported as well as sample-size dependencies. Implementation of the algorithm, simulation and analysis scripts are available. Conclusions: The deconfounding algorithm without decorrelation using quantile normalization on non-log data is proposed for biomarkers that are difficult to detect, and for cases where confounding by varying proportions of cell types is the suspected reason. In this case, a deconfounding ranking approach can be used as a powerful alternative to, or complement of, other statistical learning approaches to define candidate biomarkers for molecular diagnosis and prediction in biomedicine, in realistically noisy conditions and with moderate sample sizes. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 854 KW - differential gene expression KW - quantile normalization KW - heterogeneous tissue KW - gene expression matrix KW - homogeneous cell population KW - selection KW - microdissection Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-429343 SN - 1866-8372 IS - 854 ER - TY - GEN A1 - Lesur, Vincent A1 - Wardinski, Ingo A1 - Asari, Seiki A1 - Minchev, Borislav A1 - Mandea, Mioara T1 - Modelling the Earth's core magnetic field under flow constraints T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Two recent magnetic field models, GRIMM and xCHAOS, describe core field accelerations with similar behavior up to Spherical Harmonic (SH) degree 5, but which differ significantly for higher degrees. These discrepancies, due to different approaches in smoothing rapid time variations of the core field, have strong implications for the interpretation of the secular variation. Furthermore, the amount of smoothing applied to the highest SH degrees is essentially the modeler’s choice. We therefore investigate new ways of regularizing core magnetic field models. Here we propose to constrain field models to be consistent with the frozen flux induction equation by co-estimating a core magnetic field model and a flow model at the top of the outer core. The flow model is required to have smooth spatial and temporal behavior. The implementation of such constraints and their effects on a magnetic field model built from one year of CHAMP satellite and observatory data, are presented. In particular, it is shown that the chosen constraints are efficient and can be used to build reliable core magnetic field secular variation and acceleration model components. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 844 KW - Geomagnetism KW - core field modeling KW - core flow modeling KW - frozen-flux Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-430369 SN - 1866-8372 IS - 844 SP - 503 EP - 516 ER - TY - GEN A1 - Westendorf, Christian A1 - Bae, Albert J. A1 - Erlenkamper, Christoph A1 - Galland, Edouard A1 - Franck, Carl A1 - Bodenschatz, Eberhard A1 - Beta, Carsten T1 - Live cell flattening BT - traditional and novel approaches T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Eukaryotic cell flattening is valuable for improving microscopic observations, ranging from bright field (BF) to total internal reflection fluorescence (TIRF) microscopy. Fundamental processes, such as mitosis and in vivo actin polymerization, have been investigated using these techniques. Here, we review the well known agar overlayer protocol and the oil overlay method. In addition, we present more elaborate microfluidics-based techniques that provide us with a greater level of control. We demonstrate these techniques on the social amoebae Dictyostelium discoideum, comparing the advantages and disadvantages of each method. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 835 KW - PDMS KW - microfluidic device KW - lower channel KW - total internal reflection fluorescence KW - total internal reflection fluorescence microscopy Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-428311 SN - 1866-8372 IS - 835 ER - TY - GEN A1 - Shirzadian-Khorramabad, Reza A1 - Jing, Hai-Chun A1 - Everts, Gerja E. A1 - Schippers, Jos H. M. A1 - Hille, Jacques A1 - Dijkwel, Paul P. T1 - A mutation in the cytosolic O-acetylserine (thiol) lyase induces a genome-dependent early leaf death phenotype in Arabidopsis T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Background: Cysteine is a component in organic compounds including glutathione that have been implicated in the adaptation of plants to stresses. O-acetylserine (thiol) lyase (OAS-TL) catalyses the final step of cysteine biosynthesis. OAS-TL enzyme isoforms are localised in the cytoplasm, the plastids and mitochondria but the contribution of individual OAS-TL isoforms to plant sulphur metabolism has not yet been fully clarified. Results: The seedling lethal phenotype of the Arabidopsis onset of leaf death3-1 (old3-1) mutant is due to a point mutation in the OAS-A1 gene, encoding the cytosolic OAS-TL. The mutation causes a single amino acid substitution from Gly(162) to Glu(162), abolishing old3-1 OAS-TL activity in vitro. The old3-1 mutation segregates as a monogenic semidominant trait when backcrossed to its wild type accession Landsberg erecta (Ler-0) and the Di-2 accession. Consistent with its semi-dominant behaviour, wild type Ler-0 plants transformed with the mutated old3-1 gene, displayed the early leaf death phenotype. However, the old3-1 mutation segregates in an 11: 4: 1 (wild type: semi-dominant: mutant) ratio when backcrossed to the Colombia-0 and Wassilewskija accessions. Thus, the early leaf death phenotype depends on two semi-dominant loci. The second locus that determines the old3-1 early leaf death phenotype is referred to as odd-ler (for old3 determinant in the Ler accession) and is located on chromosome 3. The early leaf death phenotype is temperature dependent and is associated with increased expression of defence-response and oxidative-stress marker genes. Independent of the presence of the odd-ler gene, OAS-A1 is involved in maintaining sulphur and thiol levels and is required for resistance against cadmium stress. Conclusions: The cytosolic OAS-TL is involved in maintaining organic sulphur levels. The old3-1 mutation causes genome-dependent and independent phenotypes and uncovers a novel function for the mutated OAS-TL in cell death regulation. KW - acyltransferase gene family KW - cysteine synthase complex KW - map-based cloning KW - serine acetyltransferase KW - o-acetylserine(thiol)lyase gene KW - amino-acids KW - glutathione homeostasis KW - functional-analysis KW - sulfur metabolism KW - cadmium tolerance Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427574 SN - 1866-8372 IS - 833 ER - TY - JOUR A1 - Behrmann, Günter C. A1 - Kohlmann, Birgit A1 - Rupprecht, Holger A1 - Voigt, Sylvia A1 - Paulisch, Antje A1 - Piegler, Sandra A1 - Falk, André A1 - Kozakowski, Melanie A1 - Heike, Sylvester A1 - Eisner, Beate A1 - John, Peter A1 - Wilkens, Martin A1 - Lohwaßer, Roswitha A1 - Schründer-Lenzen, Agi A1 - Lauterbach, Wolfgang A1 - Schubarth, Wilfried T1 - Portal alumni T2 - Das Ehemaligen-Magazin der Universität Potsdam N2 - Das gerade begonnene Jahr wird für die Universität Potsdam ein besonderes werden, ist es doch das 20. Jahr ihres Bestehens. Auf das Erreichte ist die Hochschule mit Recht stolz. Die Universität Potsdam ist für Studieninteressierte ungebrochen attraktiv, was die steigenden Bewerberzahlen zeigen. Allein im vergangenen Jahr haben Uni-Wissenschaftler knapp 42 Millionen Euro Drittmittel eingeworben und die Liste gemeinsamer Verbundprojekte mit außeruniversitären Forschungseinrichtungen der Region wächst weiter. Zu den Erfolgen zählt weiterhin auch die steigende Anzahl von Absolventinnen und Absolventen der Hochschule. In die Gründung der Universität Potsdam am 15. Juli 1991 flossen zwei Vorgängereinrichtungen ein. Die wichtigste war die Brandenburgische Landeshochschule, vorher Pädagogische Hochschule, die über vier Jahrzehnte hinweg Lehrerinnen und Lehrer ausgebildet hat. Die Lehrerbildung hat auch für die Universität Potsdam profilbildenden Charakter, denn allein vier der fünf Fakultäten sind an der Lehrerbildung beteiligt und haben Generationen von jungen Leuten für den Lehrerberuf qualifiziert. Heute ist das Ziel aller an der Lehrerbildung Beteiligten, eine professionsorientierte, qualitativ hochwertige Lehrerbildung zu sichern, die sich an den Kompetenzen Erziehen, Unterrichten, Beraten, Betreuen, Innovieren und Organisieren orientiert. Eine besondere Herausforderung sieht die Universität Potsdam dabei in der Vernetzung von wissenschaftlicher Forschung und Lehrerbildung. Portal alumni stellt in der hier vorliegenden Ausgabe im Jubiläumsjahr zwölf Absolventen der Lehrerbildung vor. Sie berichten aus jeweils individueller Perspektive, wie sie ihr Studium an der Universität Potsdam erlebt haben und wie es sie geprägt hat. Und natürlich stellt das Magazin zugleich aktuelle Entwicklungstrends in der Lehrerbildung vor. Wie in allen Heften zuvor berichten wir von der Alumni-Arbeit des Jahres 2010 und stellen Höhepunkte des Unialltags vor. Wir wünschen Ihnen eine unterhaltsame Lektüre und sind gespannt auf Ihr Feedback zu diesem Heft. T3 - Portal alumni : das Ehemaligen-Magazin der Universität Potsdam - 8/2011 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-444587 SN - 1613-2343 IS - 8 ER - TY - GEN A1 - Budke, Alexandra T1 - Und der Zukunft abgewandt BT - ideologische Erziehung im Geographieunterricht der DDR T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Seit dem Ende der DDR, das den Zusammenbruch des Ostblocks und damit die Beendigung des »Kalten Kriegs« einleitete, wird verstärkt versucht, das Wesen dieses Staates zu definieren und damit seine Folgen auf wirtschaftlicher, sozialer, psychologischer und bildungspolitischer Ebene zu verstehen und einzuordnen. Alexandra Budke analysiert in diesem Band das Schulfach Geographie, das neben der Staatsbürgerkunde und der Geschichte ein zentrales Fach war und in dem die in den Lehrplänen definierte »staatsbürgerliche, weltanschauliche oder ideologische Erziehung« auf der Grundlage des Marxismus-Leninismus stattfinden sollte. Sie klärt, inwiefern Geographieunterricht in der DDR genutzt wurde, um geopolitische Interessen des Staates zu kommunizieren und zu verbreiten. Damit lässt sich durch die detaillierte Analyse des Fachunterrichts auch die Frage beantworten, ob SchülerInnen im Unterricht politisch manipuliert wurden und welche Handlungsmöglichkeiten die zentralen Akteure des Unterrichts, die LehrerInnen und die SchülerInnen, im Rahmen der durch die Bildungspolitik gesetzten curricularen Vorgaben wahrgenommen haben. N2 - Since the end of the German Democratic Republic and with it the collapse of the Eastern Bloc and the termination of the Cold War, efforts have been stepped up to define the real essence of the East German state and thus to understand and classify its consequences in economic, social, psychological and educational terms. In this volume, Alexandra Budke analyses the school subject of geography, which was one of the major subjects besides civics and history, in which “civic, philosophical and ideological education” as defined in the curricula was imparted from a Marxist-Leninist perspective. The author examines to what extent geography lessons in East Germany were used to communicate and propagate the geopolitical interests of the state. Her detailed analysis of geography lessons enables her to assess whether school students were politically manipulated, and what options for action were perceived by the key actors in lessons – namely the teachers and the students – within the scope of the curricula imposed by educational policy. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 813 KW - Deutschland, DDR KW - Ideologische Arbeit KW - Geografieunterricht KW - Geschichte Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-410801 SN - 978-3-89971-627-6 SN - 1866-8372 IS - 813 ER - TY - GEN A1 - Fanselow, Gisbert A1 - Lenertová, Denisa T1 - Left peripheral focus BT - mismatches between syntax and information structure T2 - Humanwissenschaftliche Reihe N2 - In Czech, German, and many other languages, part of the semantic focus of the utterance can be moved to the left periphery of the clause. The main generalization is that only the leftmost accented part of the semantic focus can be moved. We propose that movement to the left periphery is generally triggered by an unspecific edge feature of C (Chomsky 2008) and its restrictions can be attributed to requirements of cyclic linearization, modifying the theory of cyclic linearization developed by Fox and Pesetsky (2005). The crucial assumption is that structural accent is a direct consequence of being linearized at merge, thus it is indirectly relevant for (locality restrictions on) movement. The absence of structural accent correlates with given-ness. Given elements may later receive (topic or contrastive) accents, which accounts for fronting in multiple focus/contrastive topic constructions. Without any additional assumptions, the model can account for movement of pragmatically unmarked elements to the left periphery (‘formal fronting’, Frey 2005). Crucially, the analysis makes no reference at all to concepts of information structure in the syntax, in line with the claim of Chomsky (2008) that UG specifies no direct link between syntax and information structure. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 596 KW - Czech KW - German KW - Focus KW - Topic KW - Information structure KW - Intervention effects KW - Cyclic linearization KW - A-bar-movement KW - Prosody-syntax interface KW - Accentuation Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-428198 SN - 1866-8364 IS - 596 ER - TY - JOUR A1 - Wels, Nicolett A1 - Lenz, Petra A1 - Christians, Heiko A1 - Findeklee, Ulrike A1 - Zimmermann, Matthias A1 - Mangelsdorf, Birgit A1 - Horn-Conrad, Antje A1 - Görlich, Petra A1 - Peter, Andreas A1 - Rist, Juri A1 - Voigt, Juliane A1 - Eman, Friderike A1 - Micka, Bettina T1 - Portal = Glaube und Wissen: Religionswissenschaften im säkularen Staat BT - Das Potsdamer Universitätsmagazin N2 - Aus dem Inhalt: - Glauben und Wissen: Religionswissenschaften im säkularen Staat - Geheimnisse des Geistes - Mit den Dänen auf Du und Du T3 - Portal: Das Potsdamer Universitätsmagazin - 04/2010 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440225 SN - 1618-6893 IS - 04/2010 ER - TY - JOUR A1 - Mangelsdorf, Birgit A1 - Görlich, Petra A1 - Heyer-Stuffer, Till A1 - Pohlenz, Philipp A1 - Schultz, Sebastian A1 - Sommer, Ute A1 - Horn-Conrad, Antje A1 - Klein, Armin A1 - Zimmermann, Matthias A1 - Peter, Andreas A1 - Reinhardt, Ragna T1 - Portal = Unverzichtbar: Drittmittel für die Forschung BT - Das Potsdamer Universitätsmagazin N2 - Aus dem Inhalt: - Unverzichtbar: Drittmittel für die Forschung - Auf Herz und Zähne geprüft - Tango mit Goethe T3 - Portal: Das Potsdamer Universitätsmagazin - 03/2010 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440211 SN - 1618-6893 IS - 03/2010 ER - TY - JOUR A1 - Kühling, Matthias A1 - van Kempen, Britta A1 - Gebhardt, Thomas A1 - Hustedt, Thurid A1 - Ruberg, Björn A1 - Schenke, Ulrike A1 - Peter, Andreas A1 - Görlich, Petra A1 - Horn-Conrad, Antje A1 - Reinhardt, Ragna A1 - Walch, Claudia T1 - Portal = Was macht das Schaf an der Uni? Lange Nacht der Wissenschaften BT - Das Potsdamer Universitätsmagazin N2 - Aus dem Inhalt: - Was macht das Schaf an der Uni? Lange Nacht der Wissenschaften 2010! - Frauen am Dirigentenpult - Diplomaten auf Probe T3 - Portal: Das Potsdamer Universitätsmagazin - 02/2010 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440209 SN - 1618-6893 IS - 02/2010 ER - TY - JOUR A1 - Mangelsdorf, Birgit A1 - Görlich, Petra A1 - Eckardt, Barbara A1 - Peter, Andreas A1 - Horn-Conrad, Antje A1 - Findeklee, Ulrike T1 - Portal = Reform der Reform: Bologna in der Korrektur BT - Das Potsdamer Universitätsmagazin N2 - Aus dem Inhalt: - Reform der Reform – Bologna in der Korrektur - Schleudersitz Juniorprofessur? - Signalrot im Wiesengrün T3 - Portal: Das Potsdamer Universitätsmagazin - 01/2010 Y1 - 2010 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440190 SN - 1618-6893 IS - 01/2010 ER - TY - GEN A1 - Beta, Carsten T1 - Bistability in the actin cortex T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - Multi-color fluorescence imaging experiments of wave forming Dictyostelium cells have revealed that actin waves separate two domains of the cell cortex that differ in their actin structure and phosphoinositide composition. We propose a bistable model of actin dynamics to account for these experimental observation. The model is based on the simplifying assumption that the actin cytoskeleton is composed of two distinct network types, a dendritic and a bundled network. The two structurally different states that were observed in experiments correspond to the stable fixed points in the bistable regime of this model. Each fixed point is dominated by one of the two network types. The experimentally observed actin waves can be considered as trigger waves that propagate transitions between the two stable fixed points. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 756 KW - stable fixed point KW - dendritic network KW - total internal reflection fluorescence microscopy KW - dictyostelium cell KW - bistable regime Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-429385 VL - 3 IS - 12 ER - TY - GEN A1 - Kliem, Bernhard A1 - Rust, S. A1 - Seehafer, Norbert T1 - Helicity transport in a simulated coronal mass ejection T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - It has been suggested that coronal mass ejections (CMEs) remove the magnetic he-licity of their coronal source region from the Sun. Such removal is often regarded to be necessary due to the hemispheric sign preference of the helicity, which inhibits a simple annihilation by reconnection between volumes of opposite chirality. Here we monitor the relative magnetic he-licity contained in the coronal volume of a simulated flux rope CME, as well as the upward flux of relative helicity through horizontal planes in the simulation box. The unstable and erupting flux rope carries away only a minor part of the initial relative helicity; the major part remains in the volume. This is a consequence of the requirement that the current through an expanding loop must decrease if the magnetic energy of the configuration is to decrease as the loop rises, to provide the kinetic energy of the CME. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 569 KW - magnetic fields KW - MHD KW - coronal mass ejections KW - magnetohydrodynamics KW - sun Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-412907 SN - 1866-8372 IS - 569 SP - 125 EP - 128 ER - TY - GEN A1 - Hajialioghli, Robab A1 - Moazzen, Mohssen A1 - Jahangiri, Ahmad A1 - Oberhänsli, Roland A1 - Mocek, Beate A1 - Altenberger, Uwe T1 - Petrogenesis and tectonic evolution of metaluminous sub-alkaline granitoids from the Takab Complex, NW Iran T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The Takab complex is composed of a variety of metamorphic rocks including amphibolites, metapelites, mafic granulites, migmatites and meta-ultramafics, which are intruded by the granitoid. The granitoid magmatic activity occurred in relation to the subduction of the Neo-Tethys oceanic crust beneath the Iranian crust during Tertiary times. The granitoids are mainly granodiorite, quartz monzodiorite, monzonite and quartz diorite. Chemically, the magmatic rocks are characterized by ASI < 1.04, AI < 0.87 and high contents of CaO (up to ∼ 14.5 wt %), which are consistent with the I-type magmatic series. Low FeO t /(FeO t +MgO) values (< 0.75) as well as low Nb, Y and K 2 O contents of the investigated rocks resemble the calc-alkaline series. Low SiO 2 , K 2 O/Na 2 O and Al 2 O 3 accompanied by high CaO and FeO contents indicate melting of metabasites as an appropriate source for the intrusions. Negative Ti and Nb anomalies verify a metaluminous crustal origin for the protoliths of the investigated igneous rocks. These are comparable with compositions of the associated mafic migmatites, in the Takab metamorphic complex, which originated from the partial melting of amphibolites. Therefore, crustal melting and a collision-related origin for the Takab calc-alkaline intrusions are proposed here on the basis of mineralogy and geochemical characteristics. The P–T evolution during magmatic crystallization and subsolidus cooling stages is determined by the study of mineral chemistry of the granodiorite and the quartz diorite. Magmatic crystallization pressure and temperature for the quartz-diorite and the granodiorite are estimated to be P ∼ 7.8 ± 2.5 kbar, T ∼ 760 ± 75 ◦C and P ∼ 5 ± 1 kbar, T ∼ 700 ◦C, respectively. Subsolidus conditions are consistent with temperatures of ∼ 620 ◦C and ∼ 600 ◦C, and pressures of ∼ 5 kbar and ∼ 3.5 kbar for the quartz-diorite and the granodiorite, respectively. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 570 KW - granitoids KW - partial melting KW - Neo-Tethys KW - Takab KW - NW Iran Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-413100 SN - 1866-8372 IS - 570 ER - TY - GEN A1 - Carlsohn, Anja A1 - Cassel, Michael A1 - Linné, Karsten A1 - Mayer, Frank T1 - How much is too much? BT - a case report of nutritional supplement use of a high-performance athlete T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Although dietary nutrient intake is often adequate, nutritional supplement use is common among elite athletes. However, high-dose supplements or the use of multiple supplements may exceed the recommended daily allowance (RDA) of particular nutrients or even result in a daily intake above tolerable upper limits (UL). The present case report presents nutritional intake data and supplement use of a highly trained male swimmer competing at international level. Habitual energy and micronutrient intake were analysed by 3 d dietary reports. Supplement use and dosage were assessed, and total amount of nutrient supply was calculated. Micronutrient intake was evaluated based on RDA and UL as presented by the European Scientific Committee on Food, and maximum permitted levels in supplements (MPL) are given. The athlete’s diet provided adequate micronutrient content well above RDA except for vitamin D. Simultaneous use of ten different supplements was reported, resulting in excess intake above tolerable UL for folate, vitamin E and Zn. Additionally, daily supplement dosage was considerably above MPL for nine micronutrients consumed as artificial products. Risks and possible side effects of exceeding UL by the athlete are discussed. Athletes with high energy intake may be at risk of exceeding UL of particular nutrients if multiple supplements are added. Therefore, dietary counselling of athletes should include assessment of habitual diet and nutritional supplement intake. Educating athletes to balance their diets instead of taking supplements might be prudent to prevent health risks that may occur with long-term excess nutrient intake. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 515 KW - dietary supplements KW - tolerable upper limits KW - elite athletes KW - vitamins KW - minerals Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-412910 SN - 1866-8364 IS - 515 ER -