TY  - GEN
A1  - Metzler, Ralf
T1  - Anomalous Diffusion in Membranes and the Cytoplasm of Biological Cells
T2  - Biophysical journal
Y1  - 2017
U6  - https://doi.org/10.1016/j.bpj.2016.11.2577
SN  - 0006-3495
SN  - 1542-0086
VL  - 112
IS  - 3
SP  - 476A
EP  - 476A
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Gianelli, Claudia
A1  - Marzocchi, Michele
A1  - Borghi, Anna M.
T1  - Grasping the Agent’s Perspective
BT  - a Kinematics Investigation of Linguistic Perspective in Italian and German
JF  - Frontiers in psychology
KW  - perspective taking
KW  - action
KW  - language comprehension
KW  - motor chains
KW  - motor system
KW  - motor resonance
KW  - pronouns
KW  - action verbs
Y1  - 0107
U6  - https://doi.org/10.3389/fpsyg.2017.00042
SN  - 1664-1078
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - GEN
A1  - Metzler, Ralf
T1  - Gaussianity Fair
BT  - the Riddle of Anomalous yet Non-Gaussian Diffusion
T2  - Biophysical journal
Y1  - 2017
U6  - https://doi.org/10.1016/j.bpj.2016.12.019
SN  - 0006-3495
SN  - 1542-0086
VL  - 112
IS  - 3
SP  - 413
EP  - 415
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Zimmermann, Heike Hildegard
A1  - Raschke, Elena
A1  - Epp, Laura Saskia
A1  - Stoof-Leichsenring, Kathleen Rosemarie
A1  - Schwamborn, Georg
A1  - Schirrmeister, Lutz
A1  - Overduin, Pier Paul
A1  - Herzschuh, Ulrike
T1  - Sedimentary ancient DNA and pollen reveal the composition of plant organic matter in Late Quaternary permafrost sediments of the Buor Khaya Peninsula (north-eastern Siberia)
JF  - Biogeosciences
N2  - Organic matter deposited in ancient, ice-rich permafrost sediments is vulnerable to climate change and may contribute to the future release of greenhouse gases; it is thus important to get a better characterization of the plant organic matter within such sediments. From a Late Quaternary permafrost sediment core from the Buor Khaya Peninsula, we analysed plant-derived sedimentary ancient DNA (sedaDNA) to identify the taxonomic composition of plant organic matter, and undertook palynological analysis to assess the environmental conditions during deposition. Using sedaDNA, we identified 154 taxa and from pollen and non-pollen palynomorphs we identified 83 taxa. In the deposits dated between 54 and 51 kyr BP, sedaDNA records a diverse low-centred polygon plant community including recurring aquatic pond vegetation while from the pollen record we infer terrestrial open-land vegetation with relatively dry environmental conditions at a regional scale. A fluctuating dominance of either terrestrial or swamp and aquatic taxa in both proxies allowed the local hydrological development of the polygon to be traced. In deposits dated between 11.4 and 9.7 kyr BP (13.4-11.1 cal kyr BP), sedaDNA shows a taxonomic turnover to moist shrub tundra and a lower taxonomic richness compared to the older samples. Pollen also records a shrub tundra community, mostly seen as changes in relative proportions of the most dominant taxa, while a decrease in taxonomic richness was less pronounced compared to sedaDNA. Our results show the advantages of using sedaDNA in combination with palynological analyses when macrofossils are rarely preserved. The high resolution of the sedaDNA record provides a detailed picture of the taxonomic composition of plant-derived organic matter throughout the core, and palynological analyses prove valuable by allowing for inferences of regional environmental conditions.
Y1  - 2017
U6  - https://doi.org/10.5194/bg-14-575-2017
SN  - 1726-4170
SN  - 1726-4189
VL  - 14
IS  - 3
SP  - 575
EP  - 596
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Schweighöfer, F.
A1  - Moreno, J.
A1  - Bobone, Sara
A1  - Chiantia, Salvatore
A1  - Herrmann, A.
A1  - Hecht, S.
A1  - Wachtveitl, Josef
T1  - Connectivity pattern modifies excited state relaxation dynamics of fluorophore-photoswitch molecular dyads
JF  - Physical chemistry, chemical physics : a journal of European Chemical Societies
N2  - In order to modulate the emission of BODIPY fluorophores, they were connected to a diarylethene (DAE) photoswitch via phenylene-ethynylene linkers of different lengths and orientations. The latter allowed for modulation of the electronic coupling in the prepared four BODIPY-DAE dyads, which were compared also to appropriate BODIPY and DAE model compounds by steady state as well as time-resolved spectroscopies. In their open isomers, all dyads show comparable luminescence behavior indicative of an unperturbed BODIPY fluorophore. In strong contrast, in the closed isomers the BODIPY emission is efficiently quenched but the deactivation mechanism depends on the nature of the linker. The most promising dyad was rendered water-soluble by means of micellar encapsulation and aqueous suspensions were investigated by fluorescence spectroscopy and microscopy. Our results (i) illustrate that the electronic communication between the BODIPY and DAE units can indeed be fine-tuned by the nature of the linker to achieve fluorescence modulation while maintaining photoswitchability and (ii) highlight potential applications to image and control biological processes with high spatio-temporal resolution.
Y1  - 2016
U6  - https://doi.org/10.1039/c6cp07112k
SN  - 1463-9076
SN  - 1463-9084
VL  - 19
SP  - 4010
EP  - 4018
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Felser, Claudia
A1  - Phillips, Colin
A1  - Wagers, Matthew
T1  - Editorial: Encoding and Navigating Linguistic Representations in Memory
T2  - Frontiers in psychology
KW  - sentence comprehension
KW  - encoding
KW  - memory retrieval
KW  - interference
KW  - anaphor resolution
KW  - agreement processing
KW  - filler-gap dependencies
Y1  - 2017
U6  - https://doi.org/10.3389/fpsyg.2017.00164
SN  - 1664-1078
VL  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Dallmeyer, Anne
A1  - Claussen, Martin
A1  - Ni, Jian
A1  - Cao, Xianyong
A1  - Wang, Yongbo
A1  - Fischer, Nils
A1  - Pfeiffer, Madlene
A1  - Jin, Liya
A1  - Khon, Vyacheslav
A1  - Wagner, Sebastian
A1  - Haberkorn, Kerstin
A1  - Herzschuh, Ulrike
T1  - Biome changes in Asia since the mid-Holocene
BT  - an analysis of different transient Earth system model simulations
JF  - Climate of the past : an interactive open access journal of the European Geosciences Union
N2  - The large variety of atmospheric circulation systems affecting the eastern Asian climate is reflected by the complex Asian vegetation distribution. Particularly in the transition zones of these circulation systems, vegetation is supposed to be very sensitive to climate change. Since proxy records are scarce, hitherto a mechanistic understanding of the past spatio-temporal climate-vegetation relationship is lacking. To assess the Holocene vegetation change and to obtain an ensemble of potential mid-Holocene biome distributions for eastern Asia, we forced the diagnostic biome model BIOME4 with climate anomalies of different transient Holocene climate simulations performed in coupled atmosphere-ocean(-vegetation) models. The simulated biome changes are compared with pollen-based biome records for different key regions. In all simulations, substantial biome shifts during the last 6000 years are confined to the high northern latitudes and the monsoon-westerly wind transition zone, but the temporal evolution and amplitude of change strongly depend on the climate forcing. Large parts of the southern tundra are replaced by taiga during the mid-Holocene due to a warmer growing season and the boreal treeline in northern Asia is shifted northward by approx. 4 degrees in the ensemble mean, ranging from 1.5 to 6 degrees in the individual simulations, respectively. This simulated treeline shift is in agreement with pollen-based reconstructions from northern Siberia. The desert fraction in the transition zone is reduced by 21% during the mid-Holocene compared to pre-industrial due to enhanced precipitation. The desert-steppe margin is shifted westward by 5 degrees (1-9 degrees in the individual simulations). The forest biomes are expanded north-westward by 2 degrees, ranging from 0 to 4 degrees in the single simulations. These results corroborate pollen-based reconstructions indicating an extended forest area in north-central China during the mid-Holocene. According to the model, the forest-to-non-forest and steppe-to-desert changes in the climate transition zones are spatially not uniform and not linear since the mid-Holocene.
Y1  - 2017
U6  - https://doi.org/10.5194/cp-13-107-2017
SN  - 1814-9324
SN  - 1814-9332
VL  - 13
IS  - 2
SP  - 107
EP  - 134
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Molnos, Sonja
A1  - Mamdouh, Tarek
A1  - Petri, Stefan
A1  - Nocke, Thomas
A1  - Weinkauf, Tino
A1  - Coumou, Dim
T1  - A network-based detection scheme for the jet stream core
JF  - Earth system dynamics
N2  - The polar and subtropical jet streams are strong upper-level winds with a crucial influence on weather throughout the Northern Hemisphere midlatitudes. In particular, the polar jet is located between cold arctic air to the north and warmer subtropical air to the south. Strongly meandering states therefore often lead to extreme surface weather. The parameter values of the detection scheme are optimized using simulated annealing and a skill function that accounts for the zonal-mean jet stream position (Rikus, 2015). After the successful optimization process, we apply our scheme to reanalysis data covering 1979-2015 and calculate seasonal-mean probabilistic maps and trends in wind strength and position of jet streams. We present longitudinally defined probability distributions of the positions for both jets for all on the Northern Hemisphere seasons. This shows that winter is characterized by two well-separated jets over Europe and Asia (ca. 20 degrees W to 140 degrees E). In contrast, summer normally has a single merged jet over the western hemisphere but can have both merged and separated jet states in the eastern hemisphere.
Y1  - 2017
U6  - https://doi.org/10.5194/esd-8-75-2017
SN  - 2190-4979
SN  - 2190-4987
VL  - 8
IS  - 1
SP  - 75
EP  - 89
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Archambault, S.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Bourbeau, E.
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Cerruti, M.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Dwarkadas, Vikram V.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finley, J. P.
A1  - Fleischhack, H.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Griffin, S.
A1  - Huetten, M.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Johnson, C. A.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kelley-Hoskins, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Nieto, D.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Park, Nahee
A1  - Pohl, Martin
A1  - Popkow, A.
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Sadeh, I.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, K.
A1  - Slane, P.
A1  - Staszak, D.
A1  - Telezhinsky, Igor O.
A1  - Trepanier, S.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Zitzer, B.
T1  - Gamma-ray Observations of Tycho's Supernova Remnant with VERITAS and Fermi
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
KW  - material
KW  - data behind figure
Y1  - 2017
U6  - https://doi.org/10.3847/1538-4357/836/1/23
SN  - 0004-637X
SN  - 1538-4357
VL  - 836
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Judah, Gaby
A1  - De Witt Huberts, Jessie
A1  - Drassal, Allan
A1  - Aunger, Robert
T1  - The development and validation of a Real Time Location System to reliably monitor everyday activities in natural contexts
JF  - PLoS one
N2  - Introduction Methods A commercial Real Time Location System was adapted to meet these requirements and subsequently validated in three households by monitoring various bathroom behaviours. Results The results indicate that the system is robust, can monitor behaviours over the long-term in different households and can reliably distinguish between individuals. Precision rates were high and consistent. Recall rates were less consistent across households and behaviours, although recall rates improved considerably with practice at set-up of the system. The achieved precision and recall rates were comparable to the rates observed in more controlled environments using more valid methods of ground truthing. Conclusion These initial findings indicate that the system is a valuable, flexible and robust system for monitoring behaviour in its natural environment that would allow new research questions to be addressed.
Y1  - 2017
U6  - https://doi.org/10.1371/journal.pone.0171610
SN  - 1932-6203
VL  - 12
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Garakani, Tayebeh Mirzaei
A1  - Richter, Marina Juliane
A1  - Böker, Alexander
T1  - Controlling the bio-inspired synthesis of silica
JF  - Journal of colloid and interface science
N2  - The influence of different parameters on the silicification procedure using lysozyme is reported. When polyethoxysiloxane (PEOS), an internally crosslinked silica reservoir, is used, regular structures with a narrow size distribution could be obtained only via introducing the silica precursor in two steps including initial dropping and subsequent addition of residual oil phase in one portion. We found that mixing sequence of mineralizing agents in the presence of a positively charged surfactant plays a key role in terms of silica precipitation when tetraethoxyorthosilicate (TEOS) is the oil phase. In contrast, well mineralized crumpled features with high specific surface area could be synthesized in the presence of PEOS as a silica precursor polymer, regardless of mixing sequence. Moreover, introducing sodium dodecyl sulfate (SDS) as a negatively charged surfactant resulted in regular silica sphere formation only in combination with hexylene glycol (MPD) as a specific co-solvent. Finally, it is demonstrated that by inclusion of different nanoparticles even more sophisticated hybrid materials can be generated.
KW  - Silicification
KW  - Lysozyme
KW  - Polyetlioxysiloxane
KW  - High specific surface area
KW  - Surfactant
KW  - Nanoparticles
KW  - Hybrid materials
Y1  - 2016
U6  - https://doi.org/10.1016/j.jcis.2016.10.069
SN  - 0021-9797
SN  - 1095-7103
VL  - 488
SP  - 322
EP  - 334
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Guo, Li
A1  - Paycha, Sylvie
A1  - Zhang, Bin
T1  - Algebraic Birkhoff factorization and the Euler–Maclaurin formula on cones
JF  - Duke mathematical journal
N2  - We equip the space of lattice cones with a coproduct which makes it a cograded, coaugmented, connnected coalgebra. The exponential generating sum and exponential generating integral on lattice cones can be viewed as linear maps on this space with values in the space of meromorphic germs with linear poles at zero. We investigate the subdivision properties-reminiscent of the inclusion-exclusion principle for the cardinal on finite sets-of such linear maps and show that these properties are compatible with the convolution quotient of maps on the coalgebra. Implementing the algebraic Birkhoff factorization procedure on the linear maps under consideration, we factorize the exponential generating sum as a convolution quotient of two maps, with each of the maps in the factorization satisfying a subdivision property. A direct computation shows that the polar decomposition of the exponential generating sum on a smooth lattice cone yields an Euler-Maclaurin formula. The compatibility with subdivisions of the convolution quotient arising in the algebraic Birkhoff factorization then yields the Euler-Maclaurin formula for any lattice cone. This provides a simple formula for the interpolating factor by means of a projection formula.
Y1  - 2017
U6  - https://doi.org/10.1215/00127094-3715303
SN  - 0012-7094
SN  - 1547-7398
VL  - 166
IS  - 3
SP  - 537
EP  - 571
PB  - Duke Univ. Press
CY  - Durham
ER  - 
TY  - JOUR
A1  - Taylor, Vivien
A1  - Goodale, Britton
A1  - Raab, Andrea
A1  - Schwerdtle, Tanja
A1  - Reimer, Ken
A1  - Conklin, Sean
A1  - Karagas, Margaret R.
A1  - Francesconi, Kevin A.
T1  - Human exposure to organic arsenic species from seafood
JF  - The science of the total environment : an international journal for scientific research into the environment and its relationship with man
N2  - Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be nontoxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet. In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge.
KW  - Organic arsenic
KW  - Seafood
KW  - Arsenosugar
KW  - Arsenolipid
Y1  - 2017
U6  - https://doi.org/10.1016/j.scitotenv.2016.12.113
SN  - 0048-9697
SN  - 1879-1026
VL  - 580
SP  - 266
EP  - 282
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Shprits, Yuri
A1  - Kellerman, Adam C .
A1  - Aseev, Nikita
A1  - Drozdov, Alexander
A1  - Michaelis, Ingo
T1  - Multi-MeV electron loss in the heart of the radiation belts
JF  - Geophysical research letters
N2  - Significant progress has been made in recent years in understanding acceleration mechanisms in the Earth's radiation belts. In particular, a number of studies demonstrated the importance of the local acceleration by analyzing the radial profiles of phase space density (PSD) and observing building up peaks in PSD. In this study, we focus on understanding of the local loss using very similar tools. The profiles of PSD for various values of the first adiabatic invariants during the previously studied 17 January 2013 storm are presented and discussed. The profiles of PSD show clear deepening minimums consistent with the scattering by electromagnetic ion cyclotron waves. Long-term evolution shows that local minimums in PSD can persist for relatively long times. During considered interval of time the deepening minimums were observed around L* = 4 during 17 January 2013 storm and around L* = 3.5 during 1 March 2013 storm. This study shows a new method that can help identify the location, magnitude, and time of the local loss and will help quantify local loss in the future. This study also provides additional clear and definitive evidence that local loss plays a major role for the dynamics of the multi-MeV electrons.
Y1  - 2017
U6  - https://doi.org/10.1002/2016GL072258
SN  - 0094-8276
SN  - 1944-8007
VL  - 44
IS  - 3
SP  - 1204
EP  - 1209
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Liu, Lin
A1  - Cherstvy, Andrey G.
A1  - Metzler, Ralf
T1  - Facilitated Diffusion of Transcription Factor Proteins with Anomalous Bulk Diffusion
JF  - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry
N2  - What are the physical laws of the diffusive search of proteins for their specific binding sites on DNA in the presence of the macromolecular crowding in cells? We performed extensive computer simulations to elucidate the protein target search on DNA. The novel feature is the viscoelastic non-Brownian protein bulk diffusion recently observed experimentally. We examine the influence of the protein-DNA binding affinity and the anomalous diffusion exponent on the target search time. In all cases an optimal search time is found. The relative contribution of intermittent three-dimensional bulk diffusion and one-dimensional sliding of proteins along the DNA is quantified. Our results are discussed in the light of recent single molecule tracking experiments, aiming at a better understanding of the influence of anomalous kinetics of proteins on the facilitated diffusion mechanism.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.jpcb.6b12413
SN  - 1520-6106
VL  - 121
SP  - 1284
EP  - 1289
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Cannon, Forest
A1  - Carvalho, Leila M. V.
A1  - Jones, Charles
A1  - Norris, Jesse
A1  - Bookhagen, Bodo
A1  - Kiladis, George N.
T1  - Effects of topographic smoothing on the simulation of winter precipitation in High Mountain Asia
JF  - Journal of Geophysical Research: Atmospheres
N2  - Numerous studies have projected future changes in High Mountain Asia water resources based on temperature and precipitation from global circulation models (GCMs) under future climate scenarios. Although the potential benefit of such studies is immense, coarse grid-scale GCMs are unable to resolve High Mountain Asia's complex topography and thus have a biased representation of regional weather and climate. This study investigates biases in the simulation of physical mechanisms that generate snowfall and contribute to snowpack in High Mountain Asia in coarse topography experiments using the Weather Research and Forecasting model. Regional snowpack is event driven, thus 33 extreme winter orographic precipitation events are simulated at fine atmospheric resolution with 6.67 km resolution topography and smoothed 1.85° × 1.25° GCM topography. As with many modified topography experiments performed in other regions, the distribution of precipitation is highly dependent on first-order orographic effects, which dominate regional meteorology. However, we demonstrate that topographic smoothing enhances circulation in simulated extratropical cyclones, with significant impacts on orographic precipitation. Despite precipitation reductions of 28% over the highest ranges, due to reduced ascent on windward slopes, total precipitation over the study domain increased by an average of 9% in smoothed topography experiments on account of intensified extratropical cyclone dynamics and cross-barrier moisture flux. These findings identify an important source of bias in coarse-resolution simulated precipitation in High Mountain Asia, with important implications for the application of GCMs toward projecting future hydroclimate in the region.
Y1  - 2017
U6  - https://doi.org/10.1002/2016JD026038
SN  - 2169-897X
SN  - 2169-8996
VL  - 122
IS  - 3
SP  - 1456
EP  - 1474
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Müller, Juliane
A1  - Engel, Tilman
A1  - Kopinski, Stephan
A1  - Mayer, Frank
A1  - Müller, Steffen
T1  - Neuromuscular trunk activation patterns in back pain patients during one-handed lifting
JF  - World journal of orthopedics
N2  - AIM To analyze neuromuscular activity patterns of the trunk in healthy controls (H) and back pain patients (BPP) during one-handed lifting of light to heavy loads. METHODS RESULTS Seven subjects (3m/4f; 32 +/- 7 years; 171 +/- 7 cm; 65 +/- 11 kg) were assigned to BPP (pain grade >= 2) and 36 (13m/23f; 28 +/- 8 years; 174 +/- 10 cm; 71 +/- 12 kg) to H (pain grade <= 1). H and BPP did not differ significantly in anthropometrics (P > 0.05). All subjects were able to lift the light and middle loads, but 57% of BPP and 22% of H were not able to lift the heavy load (all women) chi(2) analysis revealed statistically significant differences in task failure between H vs BPP (P = 0.03). EMG-RMS ranged from 33% +/- 10%/30% +/- 9% (DL, 1 kg) to 356% +/- 148%/283% +/- 80% (VR, 20 kg) in H/BPP with no statistical difference between groups regardless of load (P > 0.05). However, the EMG-RMS of the VR was greatest in all lifting tasks for both groups and increased with heavier loads. CONCLUSION Heavier loading leads to an increase (2-to 3-fold) in trunk muscle activity with comparable patterns. Heavy loading (20 kg) leads to task failure, especially in women with back pain.
KW  - Lifting
KW  - Core
KW  - Trunk
KW  - EMG
KW  - MISPEX
Y1  - 2016
U6  - https://doi.org/10.5312/wjo.v8.i2.142
SN  - 2218-5836
VL  - 8
IS  - 2
SP  - 142
EP  - 148
PB  - Baishideng Publishing Group
CY  - Pleasanton
ER  - 
TY  - JOUR
A1  - Smirnov, Lev A.
A1  - Osipov, Grigory V.
A1  - Pikovskij, Arkadij
T1  - Chimera patterns in the Kuramoto-Battogtokh model
JF  - Journal of physics : A, Mathematical and theoretical
N2  - Kuramoto and Battogtokh (2002 Nonlinear Phenom. Complex Syst. 5 380) discovered chimera states represented by stable coexisting synchrony and asynchrony domains in a lattice of coupled oscillators. After a reformulation in terms of a local order parameter, the problem can be reduced to partial differential equations. We find uniformly rotating, spatially periodic chimera patterns as solutions of a reversible ordinary differential equation, and demonstrate a plethora of such states. In the limit of neutral coupling they reduce to analytical solutions in the form of one-and two-point chimera patterns as well as localized chimera solitons. Patterns at weakly attracting coupling are characterized by virtue of a perturbative approach. Stability analysis reveals that only the simplest chimeras with one synchronous region are stable.
KW  - nonlocal coupled oscillators
KW  - chimera state
KW  - coarse-grained order parameter
KW  - Ott-Antonsen reduction
KW  - perturbation approach
KW  - linear stability analysis
Y1  - 2017
U6  - https://doi.org/10.1088/1751-8121/aa55f1
SN  - 1751-8113
SN  - 1751-8121
VL  - 50
IS  - 8
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Reschke, Stefan
A1  - Mebs, Stefan
A1  - Sigfridsson-Clauss, Kajsa G. V.
A1  - Kositzki, Ramona
A1  - Leimkühler, Silke
A1  - Haumann, Michael
T1  - Protonation and Sulfido versus Oxo Ligation Changes at the Molybdenum Cofactor in Xanthine Dehydrogenase (XDH) Variants Studied by X-ray Absorption Spectroscopy
JF  - Inorganic chemistry
N2  - Enzymes of the xanthine oxidase family are among the best characterized mononuclear molybdenum enzymes. Open questions about their mechanism of transfer of an oxygen atom to the substrate remain. The enzymes share a molybdenum cofactor (Moco) with the metal ion binding a molybdopterin (MPT) molecule via its dithiolene function and terminal sulfur and oxygen groups. For xanthine dehydrogenase (XDH) from the bacterium Rhodobacter capsulatus, we used X-ray absorption spectroscopy to determine the Mo site structure, its changes in a pH range of 5-10, and the influence of amino acids (Glu730 and Gln179) close to Moco in wild-type (WT), Q179A, and E730A variants, complemented by enzyme kinetics and quantum chemical studies. Oxidized WT and Q179A revealed a similar Mo (VI) ion with each one MPT, Mo=O, Mo-O-, and Mo=S ligand, and a weak Mo-O(E730) bond at alkaline pH. Protonation of an oxo to a hydroxo (OH) ligand (pK similar to 6.8) causes inhibition of XDH at acidic pH, whereas deprotonated xanthine (pK similar to 8.8) is an inhibitor at alkaline pH. A similar acidic pK for the WT and Q179A. variants, as well as the metrical parameters of the Mo site and density functional theory calculations, suggested protonation at the equatorial oxo group. The sulfido was replaced with an oxo ligand in the inactive E730A variant, further showing another oxo and one Mo OH ligand at Mo, which are independent of pH. Our findings suggest a reaction mechanism for XDH in which an initial oxo rather than a hydroxo group and the sulfido ligand are essential for xanthine oxidation.
Y1  - 2017
U6  - https://doi.org/10.1021/acs.inorgchem.6b02846
SN  - 0020-1669
SN  - 1520-510X
VL  - 56
IS  - 4
SP  - 2165
EP  - 2176
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Archambault, S.
A1  - Archer, A.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Buchovecky, M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cerruti, M.
A1  - Chen, X.
A1  - Ciupik, L.
A1  - Cui, W.
A1  - Dickinson, H. J.
A1  - Eisch, J. D.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finley, J. P.
A1  - Fleischhack, H.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Gillanders, G. H.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Hutten, M.
A1  - Hakansson, N.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Humensky, T. B.
A1  - Johnson, C. A.
A1  - Kaaret, P.
A1  - Kar, P.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krause, M.
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Meagher, K.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Nguyen, T.
A1  - Nieto, D.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Pelassa, V.
A1  - Pohl, Martin
A1  - Popkow, A.
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reynolds, P. T.
A1  - Richards, G. T.
A1  - Roache, E.
A1  - Rulten, C.
A1  - Santander, M.
A1  - Sembroski, G. H.
A1  - Shahinyan, K.
A1  - Staszak, D.
A1  - Telezhinsky, Igor O.
A1  - Tucci, J. V.
A1  - Tyler, J.
A1  - Wakely, S. P.
A1  - Weiner, O. M.
A1  - Weinstein, A.
A1  - Wilhelm, Alina
A1  - Williams, D. A.
A1  - Fegan, S.
A1  - Giebels, B.
A1  - Horan, D.
A1  - Berdyugin, A.
A1  - Kuan, J.
A1  - Lindfors, E.
A1  - Nilsson, K.
A1  - Oksanen, A.
A1  - Prokoph, H.
A1  - Reinthal, R.
A1  - Takalo, L.
A1  - Zefi, F.
T1  - A Luminous and Isolated Gamma-Ray Flare from the Blazar B2 1215+30
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - B2 1215+30 is a BL-Lac-type blazar that was first detected at TeV energies by the MAGIC atmospheric Cherenkov telescopes and subsequently confirmed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS) observatory with data collected between 2009 and 2012. In 2014 February 08, VERITAS detected a large-amplitude flare from B2. 1215+30 during routine monitoring observations of the blazar 1ES. 1218+304, located in the same field of view. The TeV flux reached 2.4 times the Crab Nebula flux with a variability timescale of <3.6 hr. Multiwavelength observations with Fermi-LAT, Swift, and the Tuorla Observatory revealed a correlated high GeV flux state and no significant optical counterpart to the flare, with a spectral energy distribution where the gamma-ray luminosity exceeds the synchrotron luminosity. When interpreted in the framework of a onezone leptonic model, the observed emission implies a high degree of beaming, with Doppler factor delta > 10, and an electron population with spectral index p < 2.3.
KW  - BL Lacertae objects: individual (B2 1215+30, VER J1217+301)
KW  - galaxies: active
KW  - galaxies: jets
KW  - galaxies: nuclei
KW  - gamma rays: galaxies
Y1  - 2017
U6  - https://doi.org/10.3847/1538-4357/836/2/205
SN  - 0004-637X
SN  - 1538-4357
VL  - 836
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  -