TY  - JOUR
A1  - Lau, Skadi
A1  - Gossen, Manfred
A1  - Lendlein, Andreas
T1  - Designing cardiovascular implants taking in view the endothelial basement membrane
JF  - International journal of molecular sciences
N2  - Insufficient endothelialization of cardiovascular grafts is a major hurdle in vascular surgery and regenerative medicine, bearing a risk for early graft thrombosis. Neither of the numerous strategies pursued to solve these problems were conclusive. Endothelialization is regulated by the endothelial basement membrane (EBM), a highly specialized part of the vascular extracellular matrix. Thus, a detailed understanding of the structure-function interrelations of the EBM components is fundamental for designing biomimetic materials aiming to mimic EBM functions. In this review, a detailed description of the structure and functions of the EBM are provided, including the luminal and abluminal interactions with adjacent cell types, such as vascular smooth muscle cells. Moreover, in vivo as well as in vitro strategies to build or renew EBM are summarized and critically discussed. The spectrum of methods includes vessel decellularization and implant biofunctionalization strategies as well as tissue engineering-based approaches and bioprinting. Finally, the limitations of these methods are highlighted, and future directions are suggested to help improve future design strategies for EBM-inspired materials in the cardiovascular field.
KW  - endothelial cells
KW  - bioinstructive implants
KW  - vascular grafts
KW  - tissue
KW  - engineering
KW  - bioprinting
KW  - bioinspired materials
KW  - biological membrane
KW  - endothelial basement membrane
KW  - biomaterial
Y1  - 2021
U6  - https://doi.org/10.3390/ijms222313120
SN  - 1422-0067
VL  - 22
IS  - 23
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schneider, Sven
A1  - Lambers, Leen
A1  - Orejas, Fernando
T1  - A logic-based incremental approach to graph repair featuring delta preservation
JF  - International journal on software tools for technology transfer : STTT
N2  - We introduce a logic-based incremental approach to graph repair, generating a sound and complete (upon termination) overview of least-changing graph repairs from which a user may select a graph repair based on non-formalized further requirements. This incremental approach features delta preservation as it allows to restrict the generation of graph repairs to delta-preserving graph repairs, which do not revert the additions and deletions of the most recent consistency-violating graph update. We specify consistency of graphs using the logic of nested graph conditions, which is equivalent to first-order logic on graphs. Technically, the incremental approach encodes if and how the graph under repair satisfies a graph condition using the novel data structure of satisfaction trees, which are adapted incrementally according to the graph updates applied. In addition to the incremental approach, we also present two state-based graph repair algorithms, which restore consistency of a graph independent of the most recent graph update and which generate additional graph repairs using a global perspective on the graph under repair. We evaluate the developed algorithms using our prototypical implementation in the tool AutoGraph and illustrate our incremental approach using a case study from the graph database domain.
KW  - Nested graph conditions
KW  - Graph repair
KW  - Model repair
KW  - Consistency
KW  - restoration
KW  - Delta preservation
KW  - Graph databases
KW  - Model-driven
KW  - engineering
Y1  - 2021
U6  - https://doi.org/10.1007/s10009-020-00584-x
SN  - 1433-2779
SN  - 1433-2787
VL  - 23
IS  - 3
SP  - 369
EP  - 410
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -