TY  - JOUR
A1  - Prokopovic, Vladimir Z.
A1  - Vikulina, Anna S.
A1  - Sustr, David
A1  - Duschl, Claus
A1  - Volodkin, Dmitry
T1  - Biodegradation-Resistant Multilayers Coated with Gold Nanoparticles. Toward a Tailor-made Artificial Extracellular Matrix
JF  - Journal of colloid and interface science
N2  - Polymer multicomponent coatings such as multilayers mimic an extracellular, matrix (ECM) that attracts significant attention for the use of the multilayers as functional supports for advanced cell culture and tissue engineering. Herein, biodegradation and molecular transport in hyaluronan/polylysine multilayers coated with gold nanoparticles were described. Nanoparticle coating acts as a semipermeable barrier that governs molecular transport into/from the multilayers, and makes them biodegradation-resistant. Model protein lysozyme (mimics of ECM-soluble signals) diffuses into the multilayers as fast- and, slow-diffusing populations existing in an equilibrium,. Such a. composite system may have high potential to be exploited as degradation-resistant drug-delivery platforms suitable for cell-based applications.
KW  - hyaluronic acid
KW  - polylysine
KW  - diffusion
KW  - semipermeable
KW  - fluorescence recovery after photobleaching
KW  - layer-by-layer
KW  - enzymatic degradation
KW  - cell adhesion
Y1  - 2016
U6  - https://doi.org/10.1021/acsami.6b10095
SN  - 1944-8244
VL  - 8
SP  - 24345
EP  - 24349
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Liebig, Ferenc
A1  - Sarhan, Radwan Mohamed
A1  - Schmitt, Clemens Nikolaus Zeno
A1  - Thünemann, Andreas F.
A1  - Prietzel, Claudia Christina
A1  - Bargheer, Matias
A1  - Koetz, Joachim
T1  - Gold nanotriangles with crumble topping and their influence on catalysis and surface-enhanced raman spectroscopy
JF  - ChemPlusChem
N2  - By adding hyaluronic acid (HA) to dioctyl sodium sulfosuccinate (AOT)-stabilized gold nanotriangles (AuNTs) with an average thickness of 7.5 +/- 1 nm and an edge length of about 175 +/- 17 nm, the AOT bilayer is replaced by a polymeric HA-layer leading to biocompatible nanoplatelets. The subsequent reduction process of tetrachloroauric acid in the HA-shell surrounding the AuNTs leads to the formation of spherical gold nanoparticles on the platelet surface. With increasing tetrachloroauric acid concentration, the decoration with gold nanoparticles can be tuned. SAXS measurements reveal an increase of the platelet thickness up to around 14.5 nm, twice the initial value of bare AuNTs. HRTEM micrographs show welding phenomena between densely packed particles on the platelet surface, leading to a crumble formation while preserving the original crystal structure. Crumbles crystallized on top of the platelets enhance the Raman signal by a factor of around 20, and intensify the plasmon-driven dimerization of 4-nitrothiophenol (4-NTP) to 4,4 '-dimercaptoazobenzene in a yield of up to 50 %. The resulting crumbled nanotriangles, with a biopolymer shell and the absorption maximum in the second window for in vivo imaging, are promising candidates for biomedical sensing.
KW  - gold nanostructures
KW  - HRTEM
KW  - hyaluronic acid
KW  - monolayer formation
KW  - SERS
Y1  - 2020
U6  - https://doi.org/10.1002/cplu.201900745
SN  - 2192-6506
VL  - 85
IS  - 3
SP  - 519
EP  - 526
PB  - Wiley-VCH
CY  - Weinheim
ER  -