TY - GEN A1 - Honnen, S. A1 - Wellenberg, Anna A1 - Weides, L. A1 - Bornhorst, Julia A1 - Crone, B. A1 - Karst, U. A1 - Fritz, G. T1 - Identification of potent drug candidates for the prevention of cisplatin-induced neurotoxicity in the model organism C. elegans T2 - Naunyn-Schmiedeberg's archives of pharmacology Y1 - 2018 UR - https://link.springer.com/content/pdf/10.1007/s00210-018-1477-5.pdf U6 - https://doi.org/10.1007/s00210-018-1477-5 SN - 0028-1298 SN - 1432-1912 VL - 391 SP - S4 EP - S4 PB - Springer CY - New York ER - TY - GEN A1 - Chen, Pan A1 - Bornhorst, Julia A1 - Neely, M. Diana A1 - Avila, Daiana Silva T1 - Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress T2 - Oxidative Medicine and Cellular Longevity Y1 - 2018 U6 - https://doi.org/10.1155/2018/7612172 SN - 1942-0900 SN - 1942-0994 PB - Hindawi CY - London ER - TY - GEN A1 - Bittlingmayer, Uwe H. A1 - Gerdes, Jürgen A1 - Pinheiro, Paulo A1 - Dege, Martin A1 - Bauer, Ullrich A1 - Jäntsch, Christian A1 - Kirchhoff, Sandra A1 - Knigge, Michael A1 - Köpfer, Andreas A1 - Markovic, Sandra A1 - Okcu, Gözde A1 - Scharenberg, Katja T1 - Health Promoting Schools (HPS) and the impact of inclusion BT - the StiEL-project T2 - The European Journal of Public Health N2 - Background: The overall goal of the project ‘StiEL’ is to contribute to the professional development of teachers and other educational staff working at German secondary schools. The aim is to develop an evidence-based training concept for the inclusion of students with diverse abilities. The project is organized as a collaborative research effort of three partnering institutions and funded by the German Federal Ministry of Education and Research from 2018-2021. Methods: To support the on-going transition towards inclusive school practices, a multi-stage approach is envisaged. The first phase aims at a scoping review of existing literature and programmes on inclusion. The overview is supplemented by interviews with school staff members. Training modules are developed in the second project phase. The third phase of StiEL puts the newly developed training program into practice. The knowledge and skills acquired by the participants through the training as well as the teaching and management of inclusive classrooms after the training are evaluated through longitudinal and ethnographic approaches. The final project phase creates a best practice manual and makes the modules available via open access databases. Results: The presentation will focus on the first phase and try to explore the health-related consequences of the transition towards an inclusive school system in Germany for different participants. We will present preliminary results of expert interviews as well as some results from the literature screening. Due to our findings the current practice on German schools towards the road to inclusion is very stressful for all participants. We will explore recommendations for health promoting schools under conditions of inclusion. Conclusions: In terms of health-related consequences for all participants, the road to inclusion is very ambitious but also very stressful. Regarding the development of an inclusive school system, we need to focus much more on health and health promotion. Y1 - 2018 SN - 1101-1262 SN - 1464-360X VL - 28 IS - Supp. 4 SP - 287 EP - 288 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Schulze, Matthias Bernd A1 - Martinez-Gonzalez, Miguel A. A1 - Fung, Teresa T. A1 - Lichtenstein, Alice H. A1 - Forouhi, Nita G. T1 - Food based dietary patterns and chronic disease prevention T2 - BMJ-British medical journal N2 - Matthias B Schulze and colleagues discuss current knowledge on the associations between dietary patterns and cancer, coronary heart disease, stroke, and type 2 diabetes, focusing on areas of uncertainty and future research directions. Y1 - 2018 U6 - https://doi.org/10.1136/bmj.k2396 SN - 1756-1833 VL - 361 PB - BMJ Publishing Group CY - London ER - TY - GEN A1 - Fernando, Raquel A1 - Drescher, Cathleen A1 - Deubel, Stefanie A1 - Grune, Tilman A1 - Castro, Jose Pedro T1 - Distinct proteasomal activity for fast and slow twitch skeletal muscle during aging T2 - Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research N2 - Skeletal muscle alterations during aging lead to dysfunctional metabolism, correlating with frailty and early mortality. The loss of proteostasis is a hallmark of aging. Whether proteostasis loss plays a role in muscle aging remains elusive. To address this question we collected muscles, Soleus (SOL, type I) and Extensor digitorum longus (EDL, type II), from young (4 months) and old (25 months) C57BL/6 mice and evaluated the proteasomal system. Initial work showed decreased 26 S activity in old SOL. EDL displayed lower proteasomal activity in both ages compared to any of the SOL ages. Moreover, in order to understand if during aging there is the so-called “fiber switch from fast-to-slow”, we performed western blots against sMHC and fMHC (slow and fast myosin heavy chain, respectively). Preliminary results suggest that young SOL is composed by slow twitch fibers but also contains fast twitch fibers, while young EDL seems to be mostly composed by fast twitch fibers that level down during aging, suggesting the switch. As a conclusion, EDL seems to have less proteasomal activity, however, if this is a contributor or a consequence to the muscle fiber switch during aging still needs further investigation. Y1 - 2018 U6 - https://doi.org/10.1016/j.freeradbiomed.2018.04.393 SN - 0891-5849 SN - 1873-4596 VL - 120 SP - S119 EP - S119 PB - Elsevier CY - New York ER - TY - GEN A1 - Böckmann, Christine A1 - Ritter, Christoph A1 - Cappelletti, David T1 - Mathematical tool for a closure study of aerosol microphysical property retrieval using lidar and photometer data T2 - IGARSS 2018 - 2018 IEEE International Geoscience and Remote Sensing Symposium N2 - We present a project combining lidar, photometer and particle counter data with a regularization software tool for a closure study of aerosol microphysical property retrieval. In a first step only lidar data are used to retrieve the particle size distribution (PSD). Secondly, photometer data are added, which results in a good consistency of the retrieved PSDs. Finally, those retrieved PSDs may be compared with the measured PSD from a particle counter. The data here were taken in Ny Alesund, Svalbard, as an example. KW - Aerosol KW - Raman lidar KW - photometer KW - inversion KW - regularization KW - particle microphysics Y1 - 2018 SN - 978-1-5386-7150-4 U6 - https://doi.org/10.1109/IGARSS.2018.8518674 SN - 2153-6996 SP - 5575 EP - 5578 PB - IEEE CY - New York ER - TY - GEN A1 - Krstić, Miloš A1 - Jentzsch, Anne-Kristin T1 - Reliability, safety and security of the electronics in automated driving vehicles - joint lab lecturing approach T2 - 2018 12TH European Workshop on Microelectronics Education (EWME) N2 - This paper proposes an education approach for master and bachelor students to enhance their skills in the area of reliability, safety and security of the electronic components in automated driving. The approach is based on the active synergetic work of research institutes, academia and industry in the frame of joint lab. As an example, the jointly organized summer school with the respective focus is organized and elaborated. KW - reliability KW - safety KW - security KW - automated driving KW - joint lab Y1 - 2018 SN - 978-1-5386-1157-9 SP - 21 EP - 22 PB - IEEE CY - New York ER - TY - GEN A1 - Grünthal, Gottfried A1 - Stromeyer, Dietrich A1 - Bosse, Christian A1 - Cotton, Fabrice A1 - Bindi, Dino T1 - Correction to: The probabilistic seismic hazard assessment of Germanyversion 2016, considering the range of epistemic uncertainties and aleatory variability (vol 16, pg 4339, 2018) T2 - Bulletin of earthquake engineering : official publication of the European Association for Earthquake Engineering N2 - One paragraph of the manuscript of the paper has been inadvertently omitted in the very final stage of its compilation due to a technical mistake. Since this paragraph discusses the declustering of the used earthquake catalogue and is therefore necessary for the understanding of the seismicity data preprocessing, the authors decided to provide this paragraph in form of a correction. The respective paragraph belongs to chapter 2 of the paper, where it was placed originally, and should be inserted into the published paper before the second to the last paragraph. The omitted text reads as follows: Y1 - 2918 U6 - https://doi.org/10.1007/s10518-018-0398-5 SN - 1570-761X SN - 1573-1456 VL - 16 IS - 10 SP - 4397 EP - 4398 PB - Springer CY - Dordrecht ER - TY - GEN A1 - Granacher, Urs A1 - Völler, Heinz T1 - Gait speed is not magic, but is prognostically important in older patients T2 - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology Y1 - 2020 U6 - https://doi.org/10.1177/2047487317744053 SN - 2047-4873 SN - 2047-4881 VL - 25 IS - 2 SP - 209 EP - 211 PB - Sage Publ. CY - London ER - TY - GEN A1 - Krentz, Konrad-Felix A1 - Meinel, Christoph A1 - Graupner, Hendrik T1 - More Lightweight, yet Stronger 802.15.4 Security Through an Intra-layer Optimization T2 - Foundations and Practice of Security N2 - 802.15.4 security protects against the replay, injection, and eavesdropping of 802.15.4 frames. A core concept of 802.15.4 security is the use of frame counters for both nonce generation and anti-replay protection. While being functional, frame counters (i) cause an increased energy consumption as they incur a per-frame overhead of 4 bytes and (ii) only provide sequential freshness. The Last Bits (LB) optimization does reduce the per-frame overhead of frame counters, yet at the cost of an increased RAM consumption and occasional energy-and time-consuming resynchronization actions. Alternatively, the timeslotted channel hopping (TSCH) media access control (MAC) protocol of 802.15.4 avoids the drawbacks of frame counters by replacing them with timeslot indices, but findings of Yang et al. question the security of TSCH in general. In this paper, we assume the use of ContikiMAC, which is a popular asynchronous MAC protocol for 802.15.4 networks. Under this assumption, we propose an Intra-Layer Optimization for 802.15.4 Security (ILOS), which intertwines 802.15.4 security and ContikiMAC. In effect, ILOS reduces the security-related per-frame overhead even more than the LB optimization, as well as achieves strong freshness. Furthermore, unlike the LB optimization, ILOS neither incurs an increased RAM consumption nor requires resynchronization actions. Beyond that, ILOS integrates with and advances other security supplements to ContikiMAC. We implemented ILOS using OpenMotes and the Contiki operating system. Y1 - 2018 SN - 978-3-319-75650-9 SN - 978-3-319-75649-3 U6 - https://doi.org/10.1007/978-3-319-75650-9_12 SN - 0302-9743 SN - 1611-3349 VL - 10723 SP - 173 EP - 188 PB - Springer CY - Cham ER - TY - GEN A1 - Jeglinski-Mende, Melinda A. A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Rezension zu: Varma, Sashank ; Schwartz, Daniel L.: The mental representation of integers : an abstract-to-concrete shift in the understanding of mathematical concepts. - Cognition. - 121 (2011), 3. - S. 363 - 385 T2 - Frontiers in psychology KW - cognitive development KW - mental number line KW - negative numbers KW - embodied cognition KW - abstract concepts Y1 - 2018 U6 - https://doi.org/10.3389/fpsyg.2018.00209 SN - 1664-1078 VL - 9 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Jara, Jorge A1 - Sánchez-Reyes, Hugo A1 - Socquet, Anne A1 - Cotton, Fabrice A1 - Virieux, Jean A1 - Maksymowicz, Andrei A1 - Díaz-Mojica, John A1 - Walpersdorf, Andrea A1 - Ruiz, Javier A1 - Cotte, Nathalie A1 - Norabuena, Edmundo T1 - Corrigendum to: Kinematic study of Iquique 2014 Mw 8.1 earthquake: Understanding the segmentation of the seismogenic zone. - (Earth and planetary science letters. - 503 (2018) S. 131 – 143) T2 - Earth and planetary science letters N2 - We study the rupture processes of Iquique earthquake 8.1 (2014/04/01) and its largest aftershock 7.7 (2014/04/03) that ruptured the North Chile subduction zone. High-rate Global Positioning System (GPS) recordings and strong motion data are used to reconstruct the evolution of the slip amplitude, rise time and rupture time of both earthquakes. A two-step inversion scheme is assumed, by first building prior models for both earthquakes from the inversion of the estimated static displacements and then, kinematic inversions in the frequency domain are carried out taken into account this prior information. The preferred model for the mainshock exhibits a seismic moment of 1.73 × 1021 Nm ( 8.1) and maximum slip of ∼9 m, while the aftershock model has a seismic moment of 3.88 × 1020 ( 7.7) and a maximum slip of ∼3 m. For both earthquakes, the final slip distributions show two asperities (a shallow one and a deep one) separated by an area with significant slip deficit. This suggests a segmentation along-dip which might be related to a change of the dipping angle of the subducting slab inferred from gravimetric data. Along-strike, the areas where the seismic ruptures stopped seem to be well correlated with geological features observed from geophysical information (high-resolution bathymetry, gravimetry and coupling maps) that are representative of the long-term segmentation of the subduction margin. Considering the spatially limited portions that were broken by these two earthquakes, our results support the idea that the seismic gap is not filled yet. Y1 - 2018 U6 - https://doi.org/10.1016/j.epsl.2018.11.026 SN - 0012-821X SN - 1385-013X VL - 506 SP - 347 EP - 347 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Dahm, Torsten A1 - Heimann, Sebastian A1 - Funke, Sigward A1 - Wendt, Siegfried A1 - Rappsilber, Ivo A1 - Bindi, Dino A1 - Plenefisch, Thomas A1 - Cotton, Fabrice T1 - Correction to: Seismicity in the block mountains between Halle and Leipzig, Central Germany: centroid moment tensors, ground motion simulation, and felt intensities of two M approximate to 3 earthquakes in 2015 and 2017 (vol 22, pg 985, 2018) T2 - Journal of seismology Y1 - 2018 U6 - https://doi.org/10.1007/s10950-018-9773-6 SN - 1383-4649 SN - 1573-157X VL - 22 IS - 6 SP - 1669 EP - 1671 PB - Springer CY - Dordrecht ER - TY - GEN A1 - Ehmann, Lisa A1 - Zoller, Michael A1 - Minichmayr, Iris K. A1 - Schmitt, Maximilian V. A1 - Hartung, Niklas A1 - Huisinga, Wilhelm A1 - Zander, Johannes A1 - Kloft, Charlotte T1 - Development of a tool to identify intensive care patients at risk of meropenem therapy failure T2 - International Journal of Clinical Pharmacy Y1 - 2018 SN - 2210-7703 SN - 2210-7711 VL - 40 IS - 1 SP - 317 EP - 317 PB - Springer CY - Dordrecht ER - TY - GEN A1 - Vasishth, Shravan A1 - Mertzen, Daniela A1 - Jäger, Lena Ann A1 - Gelman, Andrew T1 - Corrigendum to: Shravan Vasishth, Daniela Mertzen, Lena A. Jäger, Andrew Gelman; The statistical significance filter leads to overoptimistic expectations of replicability. - Journal of Memory and Language. - 103 (2018), pg. 151 - 175 T2 - Journal of memory and language Y1 - 2018 U6 - https://doi.org/10.1016/j.jml.2018.09.004 SN - 0749-596X SN - 1096-0821 VL - 104 SP - 128 EP - 128 PB - Elsevier CY - San Diego ER - TY - GEN A1 - Shprits, Yuri Y. A1 - Horne, Richard B. A1 - Kellerman, Adam C. A1 - Drozdov, Alexander T1 - The dynamics of Van Allen belts revisited T2 - Nature physics N2 - In an effort to explain the formation of a narrow third radiation belt at ultra-relativistic energies detected during a solar storm in September 20121, Mann et al.2 present simulations from which they conclude it arises from a process of outward radial diffusion alone, without the need for additional loss processes from higher frequency waves. The comparison of observations with the model in Figs 2 and 3 of their Article clearly shows that even with strong radial diffusion rates, the model predicts a third belt near L* = 3 that is twice as wide as observed and approximately an order of magnitude more intense. We therefore disagree with their interpretation that “the agreement between the absolute fluxes from the model and those observed by REPT [the Relativistic Electron Proton Telescope] shown on Figs 2 and 3 is excellent.” Previous studies3 have shown that outward radial diffusion plays a very important role in the dynamics of the outer belt and is capable of explaining rapid reductions in the electron flux. It has also been shown that it can produce remnant belts (Fig. 2 of a long-term simulation study4). However, radial diffusion alone cannot explain the formation of the narrow third belt at multi-MeV during September 2012. An additional loss mechanism is required. Higher radial diffusion rates cannot improve the comparison of model presented by Mann et al. with observations. A further increase in the radial diffusion rates (reported in Fig. 4 of the Supplementary Information of ref. 2) results in the overestimation of the outer belt fluxes by up to three orders of magnitude at energy of 3.4 MeV. Observations at 2 MeV, where belts show only a two-zone structure, were not presented by Mann et al. Moreover, simulations of electrons with energies below 2 MeV with the same diffusion rates and boundary conditions used by the authors would probably produce very strong depletions down to L = 3–3.5, where L is radial distance from the centre of the Earth to the given field line in the equatorial plane. Observations do not show a non-adiabatic loss below L ∼ 4.5 for 2 MeV. Such different dynamics between 2 MeV and above 4 MeV at around L = 3.5 are another indication that particles are scattered by electromagnetic ion cyclotron (EMIC) waves that affect only energies above a certain threshold. Observations of the phase space density (PSD) provide additional evidence for the local loss of electrons. Around L* = 3.5–4 PSD shows significant decrease by an order of magnitude starting in the afternoon of 3 September (Fig. 1a), while PSD above L* = 4 is increasing. The minimum in PSD between L* = 3.5–4 continues to decrease until 4 September. This evolution demonstrates that the loss is not produced by outward diffusion. Radial diffusion cannot produce deepening minima, as it works to smooth gradients. Just as growing peaks in PSD show the presence of localized acceleration5, deepening minima show the presence of localized loss. Figure 1: Time evolution of radiation profiles in electron PSD at relativistic and ultra-relativistic energies. figure 1 a, Similar to Supplementary Fig. 3 of ref. 2, but using TS07D model10 and for μ = 2,500 MeV G−1, K = 0.05 RE G0.5 (where RE is the radius of the Earth). b, Similar to Supplementary Fig. 3 of ref. 2, but using TS07D model and for μ = 700 MeV G−1, corresponding to MeV energies in the heart of the belt. Minimum in PSD in the heart of the multi-MeV electron radiation belt between 3.5 and 4 RE deepening between the afternoon of 3 September and 5 September clearly show that the narrow remnant belt at multi-MeV below 3.5 RE is produced by the local loss. Full size image The minimum in the outer boundary is reached on the evening of 2 September. After that, the outer boundary moves up, while the minimum decreases by approximately an order of magnitude, clearly showing that this main decrease cannot be explained by outward diffusion, and requires additional loss processes. The analysis of profiles of PSD is a standard tool used, for example, in the study about electron acceleration5 and routinely used by the entire Van Allen Probes team. In the Supplementary Information, we show that this analysis is validated by using different magnetic field models. The Supplementary Information also shows that measurements are above background noise. Deepening minima at multi-MeV during the times when the boundary flux increases are clearly seen in Fig. 1a. They show that there must be localized loss, as radial diffusion cannot produce a minimum that becomes lower with time. At lower energies of 1–2 MeV, which corresponds to lower values of the first adiabatic invariant μ (Fig. 1b), the profiles are monotonic between L* = 3–3.5, consistent with the absence of scattering by EMIC waves that affect only electrons above a certain energy threshold6,7,8,9. In summary, the results of the modelling and observations presented by Mann et al. do not lend support to the claim of explaining the dynamics of the ultra-relativistic third Van Allen radiation belt in terms of an outward radial diffusion process alone. While the outward radial diffusion driven by the loss to the magnetopause2 is certainly operating during this storm, there is compelling observational and modelling2,6 evidence that shows that very efficient localized electron loss operates during this storm at multi-MeV energies, consistent with localized loss produced by EMIC waves. Y1 - 2018 U6 - https://doi.org/10.1038/nphys4350 SN - 1745-2473 SN - 1745-2481 VL - 14 IS - 2 SP - 102 EP - 103 PB - Nature Publ. Group CY - London ER - TY - GEN A1 - Shprits, Yuri Y. A1 - Zhelavskaya, Irina A1 - Green, Janet C. A1 - Pulkkinen, Antti A. A1 - Horne, Richard B. A1 - Pitchford, David A1 - Glover, Alexi T1 - Discussions on Stakeholder Requirements for Space Weather-Related Models T2 - Space Weather: The International Journal of Research and Applications N2 - Participants of the 2017 European Space Weather Week in Ostend, Belgium, discussed the stakeholder requirements for space weather-related models. It was emphasized that stakeholders show an increased interest in space weather-related models. Participants of the meeting discussed particular prediction indicators that can provide first-order estimates of the impact of space weather on engineering systems. KW - 7924 KW - 7934 KW - 7959 Y1 - 2018 U6 - https://doi.org/10.1002/2018SW001864 SN - 1542-7390 VL - 16 IS - 4 SP - 341 EP - 342 PB - American Geophysical Union CY - Washington ER - TY - GEN A1 - Tala, Mahdi A1 - Schrape, Oliver A1 - Krstić, Miloš A1 - Bertozzi, Davide T1 - Exploring the Performance-Energy Optimization Space of a Bridge Between 3D-Stacked Electronic and Optical Networks-on-Chip T2 - XXXIII Conference on Design of Circuits and Integrated Systems (DCIS) N2 - The relentless improvement of silicon photonics is making optical interconnects and networks appealing for use in miniaturized systems, where electrical interconnects cannot keep up with the growing levels of core integration due to bandwidth density and power efficiency limitations. At the same time, solutions such as 3D stacking or 2.5D integration open the door to a fully dedicated process optimization for the photonic die. However, an architecture-level integration challenge arises between the electronic network and the optical one in such tightly-integrated parallel systems. It consists of adapting signaling rates, matching the different levels of communication parallelism, handling cross-domain flow control, addressing re-synchronization concerns, and avoiding protocol-dependent deadlock. The associated energy and performance overhead may offset the inherent benefits of the emerging technology itself. This paper explores a hybrid CMOS-ECL bridge architecture between 3D-stacked technology-heterogeneous networks-on-chip (NoCs). The different ways of overcoming the serialization challenge (i.e., through an improvement of the signaling rate and/or through space-/wavelength division multiplexing options) give rise to a configuration space that the paper explores, in search for the most energy-efficient configuration for high-performance. Y1 - 2018 SN - 978-1-7281-0171-2 U6 - https://doi.org/10.1109/DCIS.2018.8681461 SN - 2471-6170 SN - 2640-5563 PB - IEEE CY - New York ER - TY - GEN A1 - Schrape, Oliver A1 - Balashov, Alexey A1 - Simevski, Aleksandar A1 - Benito, Carlos A1 - Krstić, Miloš T1 - Master-Clone placement with individual clock tree implementation BT - a Case on Physical Chip Design T2 - 2018 IEEE Nordic Circuits and Systems Conference (NORCAS): NORCHIP and International Symposium of System-on-Chip (SoC) N2 - A hybrid design approach of the hierarchical physical implementation design flow is presented and demonstrated on a fault-tolerant low-power multiprocessor system. The proposed flow allows to implement selected submodules in parallel with contrary requirements such as identical placement and individual block implementation. The overall system contains four Leon2 cores and communicates via the Waterbear framework and supports Adaptive Voltage Scaling (AVS) functionality. Three of the processor core variants are derived from the first baseline reference core but implemented individually at block level based on their clock tree specification. The chip is prepared for space applications and designed with triple modular redundancy (TMR) for control parts. The low-power performance is enabled by contemporary power and clock management control. An ASIC is fabricated in a low-power 0.13 mu m BiCMOS technology process node. KW - Hierarchical Design KW - Physical Implementation KW - Clock Tree Implementation Y1 - 2018 SN - 978-1-5386-7656-1 PB - IEEE CY - New York ER - TY - GEN A1 - Molnar, Marco A1 - Kok, Manor A1 - Engel, Tilman A1 - Kaplic, Hannes A1 - Mayer, Frank A1 - Seel, Thomas T1 - A method for lower back motion assessment using wearable 6D inertial sensors T2 - 21st International Conference on Information Fusion (FUSION) N2 - Low back pain (LBP) is a leading cause of activity limitation. Objective assessment of the spinal motion plays a key role in diagnosis and treatment of LBP. We propose a method that facilitates clinical assessment of lower back motions by means of a wireless inertial sensor network. The sensor units are attached to the right and left side of the lumbar region, the pelvis and the thighs, respectively. Since magnetometers are known to be unreliable in indoor environments, we use only 3D accelerometer and 3D gyroscope readings. Compensation of integration drift in the horizontal plane is achieved by estimating the gyroscope biases from automatically detected initial rest phases. For the estimation of sensor orientations, both a smoothing algorithm and a filtering algorithm are presented. From these orientations, we determine three-dimensional joint angles between the thighs and the pelvis and between the pelvis and the lumbar region. We compare the orientations and joint angles to measurements of an optical motion tracking system that tracks each skin-mounted sensor by means of reflective markers. Eight subjects perform a neutral initial pose, then flexion/extension, lateral flexion, and rotation of the trunk. The root mean square deviation between inertial and optical angles is about one degree for angles in the frontal and sagittal plane and about two degrees for angles in the transverse plane (both values averaged over all trials). We choose five features that characterize the initial pose and the three motions. Interindividual differences of all features are found to be clearly larger than the observed measurement deviations. These results indicate that the proposed inertial sensor-based method is a promising tool for lower back motion assessment. KW - Inertial measurement units KW - joint angle estimation KW - human motion analysis KW - low back pain KW - back motion assessment KW - avoid magnetometers KW - validation against optical motion capture KW - drift correction Y1 - 2018 SN - 978-0-9964-5276-2 SP - 799 EP - 806 PB - IEEE CY - New York ER -