TY  - JOUR
A1  - Kuhlmann, Stella
A1  - Tschorn, Mira
A1  - Arolt, Volker
A1  - Beer, Katja
A1  - Brandt, Julia
A1  - Grosse, Laura
A1  - Haverkamp, Wilhelm
A1  - Müller-Nordhorn, Jacqueline
A1  - Rieckmann, Nina
A1  - Waltenberger, Johannes
A1  - Warnke, Katharina
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
T1  - Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients
BT  - a prospective study
JF  - Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology
N2  - Objective:
Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients.
Methods:
At baseline, N = 225 CHD patients were enrolled while hospitalized. Of these, N = 190 (84%) could be followed up 6 months later. Depressive symptoms were assessed both at baseline and at the 6-months follow-up using the Patient Health Questionnaire (PHQ-9). Serum BDNF concentrations were measured using fluorometric Enzyme-linked immunosorbent assays (ELISA).
Results:
Logistic regression models showed that lower BDNF levels were associated with persistent depressive symptoms, even after adjustment for age, sex, smoking and potential medical confounders. The incidence of depressive symptoms was not related to lower BDNF levels. However, somatic comorbidity (as measured by the Charlson Comorbidity Index) was significantly associated with the incidence of depressive symptoms.
Conclusions:
Our findings suggest a role of BDNF in the link between CHD and depressive symptoms. Particularly, low serum BDNF levels could be considered as a valuable biomarker for the persistence of depressive symptoms among depressed CHD patients.
KW  - Brain-derived neurotrophic factor (BDNF)
KW  - Coronary heart disease (CHD)
KW  - Depression
KW  - Serum
Y1  - 2016
U6  - https://doi.org/10.1016/j.psyneuen.2016.12.015
SN  - 0306-4530
VL  - 77
SP  - 196
EP  - 202
PB  - Elsevier Science
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Kallies, Gunnar
A1  - Rapp, Michael Armin
A1  - Fydrich, Thomas
A1  - Fehm, Lydia
A1  - Tschorn, Mira
A1  - Teran, Christina
A1  - Schwefel, Melanie
A1  - Pietrek, Anou F.
A1  - Henze, Romy
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
A1  - Heinzel, Stephan
A1  - Heissel, Andreas
T1  - Serum brain-derived neurotrophic factor (BDNF) at rest and after acute aerobic exercise in major depressive disorder
JF  - Psychoneuroendocrinology
N2  - Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional possibly brain-derived mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.
KW  - Brain-derived neurotrophic factor (BDNF)
KW  - Platelets
KW  - Major depressive disorder
KW  - Physical exercise
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.12.015
SN  - 0306-4530
VL  - 102
SP  - 212
EP  - 215
PB  - Elsevier
CY  - Oxford
ER  -