TY  - JOUR
A1  - Wessig, Pablo
A1  - Budach, Dennis B.
A1  - Thünemann, Andreas F.
T1  - Dendrimers with Oligospiroketal (OSK) Building Blocks: Synthesis and Properties
JF  - Chemistry - a European journal
N2  - The development of novel dendrimers containing oligospiroketal (OSK) rods as building blocks is described. The linkage between the core unit (CU), branching units (BU), and OSK rods relies on the CuAAC reaction between terminal alkynes and azides. Two different strategies of dendrimer synthesis were investigated and it was found that the convergent approach is clearly superior to the divergent one. SAXS measurements and MD simulations indicate that the obtained dendrimer features a globular structure with very low density. Obviously, the OSK rods stabilize a rather loose mass-fractal structure.
KW  - click chemistry
KW  - dendrimers
KW  - molecular rods
KW  - oxygen heterocycles
KW  - SAXS
Y1  - 2015
U6  - https://doi.org/10.1002/chem.201501386
SN  - 0947-6539
SN  - 1521-3765
VL  - 21
IS  - 29
SP  - 10466
EP  - 10471
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Techen, Anne
A1  - Czapla, Sylvia
A1  - Möllnitz, Kristian
A1  - Budach, Dennis B.
A1  - Wessig, Pablo
A1  - Kumke, Michael Uwe
T1  - Synthesis and spectroscopic characterization of fluorophore-labeled oligospiroketal rods
JF  - Helvetica chimica acta
N2  - Fluorescence probes consisting of well-established fluorophores in combination with rigid molecular rods based on spirane-type structures were investigated with respect to their fluorescence properties under different solvent conditions. The attachment of the dyes was accomplished by 1,3-dipolar cycloaddition between alkynes and azides (click' reaction) and is a prime example for a novel class of sensor constructs. Especially, the attachment of two (different) fluorophores on opposite sides of the molecular rods paves the way to new sensor systems with less bulky (compared to the conventional DNA- or protein-based concepts), nevertheless rigid spacer constructs, e.g., for FRET-based sensing applications. A detailed photophysical characterization was performed in MeOH (and in basic H2O/MeOH mixtures) for i) rod constructs containing carboxyfluorescein, ii) rod constructs containing carboxyrhodamine, iii) rod constructs containing both carboxyfluorescein and carboxyrhodamine, and iv) rod constructs containing both pyrene and perylene parts. For each dye (pair), two rod lengths with different numbers of spirane units were synthesized and investigated. The rod constructs were characterized in ensemble as well as single-molecule fluorescence experiments with respect to i) specific roddye and ii) dyedye interactions. In addition to MeOH and MeOH/NaOH, the rod constructs were also investigated in micellar systems, which were chosen as a simplified model for membranes.
KW  - Molecular rods
KW  - Forster resonance energy transfer (FRET)
KW  - Carboxyfluorescein
KW  - Carboxyrhodamine
KW  - Pyrene
KW  - Perylene
KW  - Fluorescence
Y1  - 2013
U6  - https://doi.org/10.1002/hlca.201200616
SN  - 0018-019X
SN  - 1522-2675
VL  - 96
IS  - 11
SP  - 2046
EP  - 2067
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - THES
A1  - Budach, Dennis B.
T1  - Synthese von Dendrimeren aus Oligospiroketal-Bausteinen
Y1  - 2014
ER  -