TY - JOUR A1 - Yarman, Aysu A1 - Dechtrirat, Decha A1 - Bosserdt, Maria A1 - Jetzschmann, Katharina J. A1 - Gajovic-Eichelmann, Nenad A1 - Scheller, Frieder W. T1 - Cytochrome c-derived hybrid systems based on moleculary imprinted polymers JF - Electroanalysis : an international journal devoted to fundamental and practical aspects of electroanalysis N2 - Hybrid architectures which combine a MIP with an immobilized affinity ligand or a biocatalyst sum up the advantages of both components. In this paper, hybrid architectures combining a layer of a molecularly imprinted electropolymer with a mini-enzyme or a self-assembled monolayer will be presented. (i) Microperoxidase-11 (MP-11) catalyzed oxidation of the drug aminopyrine on a product-imprinted sublayer: The peroxide dependent conversion of the analyte aminopyrine takes place in the MP-11 containing layer on top of a product-imprinted electropolymer on the indicator electrode. The hierarchical architecture resulted in the elimination of interfering signals for ascorbic acid and uric acid. An advantage of the new hierarchical structure is the separation of MIP formation by electropolymerization and immobilization of the catalyst. In this way it was for the first time possible to integrate an enzyme with a MIP layer in a sensor configuration. This combination has the potential to be transferred to other enzymes, e.g. P450, opening the way to clinically important analytes. (ii) Epitope-imprinted poly-scopoletin layer for binding of the C-terminal peptide and cytochrome c (Cyt c): The MIP binds both the target peptide and the parent protein almost eight times stronger than the non-imprinted polymer with affinities in the lower micromolar range. Exchange of only one amino acid in the peptide decreases the binding by a factor of five. (iii) MUA-poly-scopoletin MIP for cytochrome c: Cyt c bound to the MIP covered gold electrode exhibits direct electron transfer with a redox potential and rate constant typical for the native protein. The MIP cover layer suppresses the displacement of the target protein by BSA or myoglobin. The combination of protein imprinted polymers with an efficient electron transfer is a new concept for characterizing electroactive proteins such as Cyt c. The competition with other proteins shows that the MIP binds its target Cyt c preferentially and that molecular shape and the charge of protein determine the binding of interfering proteins. KW - Molecularly imprinted polymers KW - Microperoxidase-11 KW - Cytochrome c KW - Catalytically active MIPs KW - Epitope imprinting KW - Monoclonal MIPs Y1 - 2015 U6 - https://doi.org/10.1002/elan.201400592 SN - 1040-0397 SN - 1521-4109 VL - 27 IS - 3 SP - 573 EP - 586 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wu, Lei A1 - Glebe, Ulrich A1 - Böker, Alexander T1 - Surface-initiated controlled radical polymerizations from silica nanoparticles, gold nanocrystals, and bionanoparticles JF - Polymer Chemistry N2 - In recent years, core/shell nanohybrids containing a nanoparticle core and a distinct surrounding shell of polymer brushes have received extensive attention in nanoelectronics, nanophotonics, catalysis, nanopatterning, drug delivery, biosensing, and many others. From the large variety of existing polymerization methods on the one hand and strategies for grafting onto nanoparticle surfaces on the other hand, the combination of grafting-from with controlled radical polymerization (CRP) techniques has turned out to be the best suited for synthesizing these well-defined core/shell nanohybrids and is known as surface-initiated CRP. Most common among these are surface-initiated atom transfer radical polymerization (ATRP), surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization, and surface-initiated nitroxide-mediated polymerization (NMP). This review highlights the state of the art of growing polymers from nanoparticles using surface-initiated CRP techniques. We focus on mechanistic aspects, synthetic procedures, and the formation of complex architectures as well as novel properties. From the vast number of examples of nanoparticle/polymer hybrids formed by surface-initiated CRP techniques, we present nanohybrid formation from the particularly important and most studied silica nanoparticles, gold nanocrystals, and proteins which can be regarded as bionanoparticles. Y1 - 2015 U6 - https://doi.org/10.1039/c5py00525f SN - 1759-9954 SN - 1759-9962 VL - 6 IS - 29 SP - 5143 EP - 5184 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Spahn, Hannah T1 - Poetics of character: transatlantic encounters, 1700-1900 JF - EARLY AMERICAN LITERATURE Y1 - 2015 SN - 0012-8163 SN - 1534-147X VL - 50 IS - 2 SP - 616 EP - 621 PB - Univ. of North Carolina Press CY - Chapel Hill ER - TY - JOUR A1 - Demske, Ulrike T1 - Adverbial Clauses, Main Clause Phenomena, and the composition of the Left Periphery JF - Studies in language Y1 - 2015 U6 - https://doi.org/10.1075/sl.39.1.09dem SN - 0378-4177 VL - 39 IS - 1 SP - 235 EP - 243 PB - Benjamins CY - Amsterdam ER - TY - JOUR A1 - Hasselhoff, Görge K. T1 - Midrash Unbound. Transformations and Innovations JF - Zeitschrift für Religions- und Geistesgeschichte Y1 - 2015 SN - 0044-3441 VL - 67 IS - 2 SP - 205 EP - 206 PB - Brill CY - Leiden ER - TY - JOUR A1 - Piper, Ernst T1 - Alfred Rosenberg. The Diaries of 1934-1944 JF - Deutsche Zeitschrift für Geschichtswissenschaft Y1 - 2015 SN - 0044-2828 SN - 1618-0372 VL - 63 IS - 7-8 SP - 705 EP - 707 PB - Metropol-Verl. CY - Berlin ER - TY - JOUR A1 - Huetges, Annett A1 - Fay, Doris T1 - Gender influences on career development a brief review JF - Journal of personnel psychology. Y1 - 2015 U6 - https://doi.org/10.1027/1866-5888/a000152 SN - 1866-5888 SN - 2190-5150 VL - 14 IS - 3 SP - 113 EP - 120 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Schoeps, Julius H. T1 - Jewish experiences and loyalty conflicts in the first World War JF - Zeitschrift für Religions- und Geistesgeschichte Y1 - 2015 SN - 0044-3441 VL - 67 IS - 3-4 SP - 325 EP - 326 PB - Brill CY - Leiden ER - TY - JOUR A1 - Martinez-Ferreiro, Silvia A1 - de Aguiar, Vania A1 - Rofes, Adria T1 - Non-fluent aphasia in Ibero-Romance: a review of morphosyntactic deficits JF - Aphasiology : an international, interdisciplinary journal N2 - Background: Castilian-Spanish, Catalan, Galician, and European Portuguese are the most widely spoken languages of the Ibero-Romance group. An increasing number of authors have addressed the impact of aphasia on the morphosyntax of these varieties. However, accurate linguistic characterisations are scarce and the different sources of data have not been yet compiled.Aims: To stimulate state-of-the-art research, we provided a comprehensive summary of morphosyntactic aspects of Ibero-Romance and a review of how these are affected in non-fluent aphasia. The topics we dealt with are the use of verb argument structure and morphology, sentential negation and word order, definite articles, personal and reflexive pronouns, passives, topicalised constructions, questions, and relative clauses.Methods & Procedures: An exhaustive fieldwork and search of PubMed, Web of Science, and Medline records were performed to retrieve studies focused on morphosyntactic issues concerning the Ibero-Romance varieties. A total of 27 studies produced by 46 authors of varying background emerged. We did not review studies of category-specific deficits and aspects related to bilingual aphasia, although we assume that most speakers of Galician and Catalan are bilingual. Studies of spontaneous speech were included when no controlled experimental tasks were available.Outcomes & Results: The morphosyntactic commonalities of Ibero-Romance have been tackled from different theoretical perspectives. There exist asymmetries in findings which we explain with the use of different tasks (and task complexity) and individual differences between participants.Conclusions: Discourse-linking factors as well as deviations from the canonical pattern are recurrent answers to these asymmetries. A comprehensive theory of impairments in non-fluent aphasia integrating relevant aspects of both structural and processing accounts seems necessary. KW - non-fluent aphasia KW - morphosyntax KW - Ibero-Romance Y1 - 2015 U6 - https://doi.org/10.1080/02687038.2014.958915 SN - 0268-7038 SN - 1464-5041 VL - 29 IS - 1 SP - 101 EP - 126 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Piepoli, Massimo F. A1 - Corra, Ugo A1 - Abreu, Ana A1 - Cupples, Margaret A1 - Davos, Costantinos A1 - Doherty, Patrick A1 - Hoefer, Stephan A1 - Garcia-Porrero, Esteban A1 - Rauchi, Bernhard A1 - Vigorito, Carlo A1 - Völler, Heinz A1 - Schmid, Jean-Paul T1 - Challenges in secondary prevention of cardiovascular diseases A review of the current practice JF - International journal of cardiology N2 - With the changing demography of populations and increasing prevalence of co-morbidity, frail patients and more complex cardiac conditions, the modern medicine is facing novel challenges leading to rapid innovation where evidence and experiences are lacking. This scenario is also evident in cardiovascular disease prevention, which continuously needs to accommodate its ever changing strategies, settings, and goals. The present paper summarises actual challenges of secondary prevention, and discusses how this intervention should not only be effective but also efficient. By this way the paper tries to bridge the gaps between research and real-world findings and thereby may find ways to improve standard care. (C) 2014 Elsevier Ireland Ltd. All rights reserved. KW - Cardiac rehabilitation KW - Cardiovascular risk factor KW - Long term management KW - Secondary prevention Y1 - 2015 U6 - https://doi.org/10.1016/j.ijcard.2014.11.107 SN - 0167-5273 SN - 1874-1754 VL - 180 SP - 114 EP - 119 PB - Elsevier CY - Clare ER - TY - JOUR A1 - Kirchner, Sebastian A1 - Ignatova, Zoya T1 - Emerging roles of tRNA in adaptive translation, signalling dynamics and disease JF - Nature reviews N2 - tRNAs, nexus molecules between mRNAs and proteins, have a central role in translation. Recent discoveries have revealed unprecedented complexity of tRNA biosynthesis, modification patterns, regulation and function. In this Review, we present emerging concepts regarding how tRNA abundance is dynamically regulated and how tRNAs (and their nucleolytic fragments) are centrally involved in stress signalling and adaptive translation, operating across a wide range of timescales. Mutations in tRNAs or in genes affecting tRNA biogenesis are also linked to complex human diseases with surprising heterogeneity in tissue vulnerability, and we highlight cell-specific aspects that modulate the disease penetrance of tRNA-based pathologies. Y1 - 2015 U6 - https://doi.org/10.1038/nrg3861 SN - 1471-0056 SN - 1471-0064 VL - 16 IS - 2 SP - 98 EP - 112 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Benina, Maria A1 - Ribeiro, Dimas Mendes A1 - Gechev, Tsanko S. A1 - Müller-Röber, Bernd A1 - Schippers, Jos H. M. T1 - A cell type-specific view on the translation of mRNAs from ROS-responsive genes upon paraquat treatment of Arabidopsis thaliana leaves JF - Plant, cell & environment : cell physiology, whole-plant physiology, community physiology N2 - Oxidative stress causes dramatic changes in the expression levels of many genes. The formation of a functional protein through successful mRNA translation is central to a coordinated cellular response. To what extent the response towards reactive oxygen species (ROS) is regulated at the translational level is poorly understood. Here we analysed leaf- and tissue-specific translatomes using a set of transgenic Arabidopsis thaliana lines expressing a FLAG-tagged ribosomal protein to immunopurify polysome-bound mRNAs before and after oxidative stress. We determined transcript levels of 171 ROS-responsive genes upon paraquat treatment, which causes formation of superoxide radicals, at the whole-organ level. Furthermore, the translation of mRNAs was determined for five cell types: mesophyll, bundle sheath, phloem companion, epidermal and guard cells. Mesophyll and bundle sheath cells showed the strongest response to paraquat treatment. Interestingly, several ROS-responsive transcription factors displayed cell type-specific translation patterns, while others were translated in all cell types. In part, cell type-specific translation could be explained by the length of the 5-untranslated region (5-UTR) and the presence of upstream open reading frames (uORFs). Our analysis reveals insights into the translational regulation of ROS-responsive genes, which is important to understanding cell-specific responses and functions during oxidative stress. The study illustrates the response of different Arabidopsis thaliana leaf cells and tissues to oxidative stress at the translational level, an aspect of reactive oxygen species (ROS) biology that has been little studied in the past. Our data reveal insights into how translational regulation of ROS-responsive genes is fine-tuned at the cellular level, a phenomenon contributing to the integrated physiological response of leaves to stresses involving changes in ROS levels. KW - Arabidopsis KW - gene regulation KW - oxidative stress KW - tissue-specific KW - translation Y1 - 2015 U6 - https://doi.org/10.1111/pce.12355 SN - 0140-7791 SN - 1365-3040 VL - 38 IS - 2 SP - 349 EP - 363 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Warren, Ben H. A1 - Simberloff, Daniel A1 - Ricklefs, Robert E. A1 - Aguilee, Robin A1 - Condamine, Fabien L. A1 - Gravel, Dominique A1 - Morlon, Helene A1 - Mouquet, Nicolas A1 - Rosindell, James A1 - Casquet, Juliane A1 - Conti, Elena A1 - Cornuault, Josselin A1 - Maria Fernandez-Palacios, Jose A1 - Hengl, Tomislav A1 - Norder, Sietze J. A1 - Rijsdijk, Kenneth F. A1 - Sanmartin, Isabel A1 - Strasberg, Dominique A1 - Triantis, Kostas A. A1 - Valente, Luis M. A1 - Whittaker, Robert J. A1 - Gillespie, Rosemary G. A1 - Emerson, Brent C. A1 - Thebaud, Christophe T1 - Islands as model systems in ecology and evolution: prospects fifty years after MacArthur-Wilson JF - Ecology letters N2 - The study of islands as model systems has played an important role in the development of evolutionary and ecological theory. The 50th anniversary of MacArthur and Wilson's (December 1963) article, An equilibrium theory of insular zoogeography', was a recent milestone for this theme. Since 1963, island systems have provided new insights into the formation of ecological communities. Here, building on such developments, we highlight prospects for research on islands to improve our understanding of the ecology and evolution of communities in general. Throughout, we emphasise how attributes of islands combine to provide unusual research opportunities, the implications of which stretch far beyond islands. Molecular tools and increasing data acquisition now permit re-assessment of some fundamental issues that interested MacArthur and Wilson. These include the formation of ecological networks, species abundance distributions, and the contribution of evolution to community assembly. We also extend our prospects to other fields of ecology and evolution - understanding ecosystem functioning, speciation and diversification - frequently employing assets of oceanic islands in inferring the geographic area within which evolution has occurred, and potential barriers to gene flow. Although island-based theory is continually being enriched, incorporating non-equilibrium dynamics is identified as a major challenge for the future. KW - Community assembly KW - diversification KW - ecosystem functioning KW - genomics KW - island biogeography KW - islands as model systems KW - speciation Y1 - 2015 U6 - https://doi.org/10.1111/ele.12398 SN - 1461-023X SN - 1461-0248 VL - 18 IS - 2 SP - 200 EP - 217 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Petrov, Veselin A1 - Hille, Jacques A1 - Müller-Röber, Bernd A1 - Gechev, Tsanko S. T1 - ROS-mediated abiotic stress-induced programmed cell death in plants JF - Frontiers in plant science N2 - During the course of their ontogenesis plants are continuously exposed to a large variety of abiotic stress factors which can damage tissues and jeopardize the survival of the organism unless properly countered. While animals can simply escape and thus evade stressors, plants as sessile organisms have developed complex strategies to withstand them. When the intensity of a detrimental factor is high, one of the defense programs employed by plants is the induction of programmed cell death (PCD). This is an active, genetically controlled process which is initiated to isolate and remove damaged tissues thereby ensuring the survival of the organism. The mechanism of PCD induction usually includes an increase in the levels of reactive oxygen species (ROS) which are utilized as mediators of the stress signal. Abiotic stress-induced PCD is not only a process of fundamental biological importance, but also of considerable interest to agricultural practice as it has the potential to significantly influence crop yield. Therefore, numerous scientific enterprises have focused on elucidating the mechanisms leading to and controlling PCD in response to adverse conditions in plants. This knowledge may help develop novel strategies to obtain more resilient crop varieties with improved tolerance and enhanced productivity. The aim of the present review is to summarize the recent advances in research on ROS-induced PCD related to abiotic stress and the role of the organelles in the process. KW - abiotic stress KW - programmed cell death KW - reactive oxygen species KW - signal transduction KW - stress adaptation Y1 - 2015 U6 - https://doi.org/10.3389/fpls.2015.00069 SN - 1664-462X VL - 6 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Acharya, B. S. A1 - Aramo, C. A1 - Babic, A. A1 - Barrio, J. A. A1 - Baushev, Anton N. A1 - Tjus, J. Becker A1 - Berge, David A1 - Bohacova, M. A1 - Bonardi, A. A1 - Brown, A. A1 - Bugaev, V. A1 - Bulik, Tomasz A1 - Burton, M. A1 - Busetto, G. A1 - Caraveo, P. A. A1 - Carosi, R. A1 - Carr, John A1 - Chadwick, Paula M. A1 - Chudoba, J. A1 - Conforti, V. A1 - Connaughton, V. A1 - Contreras, J. L. A1 - Cotter, G. A1 - Dazzi, F. A1 - De Franco, A. A1 - de la Calle, I. A1 - Lopez, R. de los Reyes A1 - De Lotto, B. A1 - De Palma, F. A1 - Di Girolamo, T. A1 - Di Giulio, C. A1 - Di Pierro, F. A1 - Dournaux, J. -L. A1 - Dwarkadas, Vikram V. A1 - Ebr, J. A1 - Egberts, Kathrin A1 - Fesquet, M. A1 - Fleischhack, H. A1 - Font, L. A1 - Fontaine, G. A1 - Foerster, A. A1 - Füßling, Matthias A1 - Garcia, B. A1 - Lopez, R. Garcia A1 - Garczarczyk, M. A1 - Gargano, F. A1 - Garrido, D. A1 - Gaug, M. A1 - Giglietto, N. A1 - Giordano, F. A1 - Giuliani, A. A1 - Godinovic, N. A1 - Gonzalez, M. M. A1 - Grabarczyk, T. A1 - Hassan, T. A1 - Hoerandel, J. A1 - Hrabovsky, M. A1 - Hrupec, D. A1 - Humensky, T. B. A1 - Huovelin, J. A1 - Jamrozy, M. A1 - Janecek, P. A1 - Kaaret, P. E. A1 - Katz, U. A1 - Kaufmann, S. A1 - Khelifi, B. A1 - Kluzniak, W. A1 - Kocot, J. A1 - Komin, N. A1 - Kubo, H. A1 - Kushida, J. A1 - Lamanna, G. A1 - Lee, W. H. A1 - Lenain, J. -P. A1 - Lohse, T. A1 - Lombardi, S. A1 - Lopez-Coto, R. A1 - Lopez-Oramas, A. A1 - Lucarelli, F. A1 - Maccarone, M. C. A1 - Maier, G. A1 - Majumdar, P. A1 - Malaguti, G. A1 - Mandat, D. A1 - Mazziotta, Mario Nicola A1 - Meagher, K. A1 - Mirabal, N. A1 - Morselli, A. A1 - Moulin, Emmanuel A1 - Niemiec, J. A1 - Nievas, M. A1 - Nishijima, K. A1 - Nosek, D. A1 - Nunio, F. A1 - Ohishi, M. A1 - Ohm, S. A1 - Ong, R. A. A1 - Orito, R. A1 - Otte, N. A1 - Palatka, M. A1 - Pareschi, G. A1 - Pech, M. A1 - Persic, M. A1 - Pohl, Manuela A1 - Prouza, M. A1 - Quirrenbach, A. A1 - Raino, S. A1 - Fernandez, G. Rodriguez A1 - Romano, Patrizia A1 - Rovero, A. C. A1 - Rudak, B. A1 - Schovanek, P. A1 - Shayduk, M. A1 - Siejkowski, H. A1 - Sillanpaa, A. A1 - Stefanik, S. A1 - Stolarczyk, T. A1 - Szanecki, M. A1 - Szepieniec, T. A1 - Tejedor, L. A. A1 - Telezhinsky, Igor O. A1 - Teshima, M. A1 - Tibaldo, L. A1 - Tibolla, O. A1 - Tovmassian, G. A1 - Travnicek, P. A1 - Trzeciak, M. A1 - Vallania, P. A1 - van Eldik, C. A1 - Vercellone, S. A1 - Vigorito, C. A1 - Wagner, S. J. A1 - Wakely, S. P. A1 - Weinstein, A. A1 - Wierzcholska, A. A1 - Wilhelm, Alina A1 - Wojcik, P. A1 - Yoshikoshi, T. T1 - The Cherenkov Telescope Array potential for the study of young supernova remnants JF - Astroparticle physics N2 - Supernova remnants (SNRs) are among the most important targets for gamma-ray observatories. Being prominent non-thermal sources, they are very likely responsible for the acceleration of the bulk of Galactic cosmic rays (CRS). To firmly establish the SNR paradigm for the origin of cosmic rays, it should be confirmed that protons are indeed accelerated in, and released from, SNRs with the appropriate flux and spectrum. This can be done by detailed theoretical models which account for microphysics of acceleration and various radiation processes of hadrons and leptons. The current generation of Cherenkov telescopes has insufficient sensitivity to constrain theoretical models. A new facility, the Cherenkov Telescope Array (CTA), will have superior capabilities and may finally resolve this long standing issue of high-energy astrophysics. We want to assess the capabilities of CTA to reveal the physics of various types of SNRs in the initial 2000 years of their evolution. During this time, the efficiency to accelerate cosmic rays is highest. We perform time-dependent simulations of the hydrodynamics, the magnetic fields, the cosmic-ray acceleration, and the non-thermal emission for type Ia, Ic and IIP SNRs. We calculate the CTA response to the y-ray emission from these SNRs for various ages and distances, and we perform a realistic analysis of the simulated data. We derive distance limits for the detectability and resolvability of these SNR types at several ages. We test the ability of CTA to reconstruct their morphological and spectral parameters as a function of their distance. Finally, we estimate how well CTA data will constrain the theoretical models. (C) 2014 Elsevier B.V. All rights reserved. KW - Acceleration of particles KW - Gamma rays: General KW - ISM: Supernova remnants KW - Radiation mechanisms: Non-termal Y1 - 2015 U6 - https://doi.org/10.1016/j.astropartphys.2014.08.005 SN - 0927-6505 SN - 1873-2852 VL - 62 SP - 152 EP - 164 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Mendel, Ralf R. A1 - Leimkühler, Silke T1 - The biosynthesis of the molybdenum cofactors JF - Journal of biological inorganic chemistry N2 - The biosynthesis of the molybdenum cofactors (Moco) is an ancient, ubiquitous, and highly conserved pathway leading to the biochemical activation of molybdenum. Moco is the essential component of a group of redox enzymes, which are diverse in terms of their phylogenetic distribution and their architectures, both at the overall level and in their catalytic geometry. A wide variety of transformations are catalyzed by these enzymes at carbon, sulfur and nitrogen atoms, which include the transfer of an oxo group or two electrons to or from the substrate. More than 50 molybdoenzymes were identified to date. In all molybdoenzymes except nitrogenase, molybdenum is coordinated to a dithiolene group on the 6-alkyl side chain of a pterin called molybdopterin (MPT). The biosynthesis of Moco can be divided into three general steps, with a fourth one present only in bacteria and archaea: (1) formation of the cyclic pyranopterin monophosphate, (2) formation of MPT, (3) insertion of molybdenum into molybdopterin to form Moco, and (4) additional modification of Moco in bacteria with the attachment of a nucleotide to the phosphate group of MPT, forming the dinucleotide variant of Moco. This review will focus on the biosynthesis of Moco in bacteria, humans and plants. KW - Molybdenum KW - Molybdenum cofactor KW - cPMP KW - bis-MGD KW - Sulfuration KW - Sulfite oxidase Y1 - 2015 U6 - https://doi.org/10.1007/s00775-014-1173-y SN - 0949-8257 SN - 1432-1327 VL - 20 IS - 2 SP - 337 EP - 347 PB - Springer CY - New York ER - TY - JOUR A1 - Taubert, Andreas T1 - Electrospinning of Ionogels: Current Status and Future Perspectives JF - European journal of inorganic chemistry : a journal of ChemPubSoc Europe N2 - Ionogels (IGs), also termed ion gels, are functional hybrid materials based on an ionic liquid (IL) and a polymeric, hybrid, or inorganic matrix. IGs combine the properties of the matrix such as mechanical strength with IL properties like high ionic conductivity, high thermal stability, or catalytic activity. IGs are thus attractive for many applications, but the vast majority of IGs made and published so far are bulk materials or dense films. Applications like sensing or catalysis, however, would benefit from IGs with high surface areas or defined surface morphologies or architectures. In spite of this, only relatively few examples of high-surface-area IGs have been made so far; this has mostly been achieved by electrospinning, which has proven to be a promising strategy towards advanced IGs. The current review discusses first developments and outlines the future potential of electrospun ionogels, predominantly from a materials and inorganic chemistry perspective. KW - Ionic liquids KW - Ionogels KW - Hybrid materials KW - Electrospinning KW - Heterogeneous catalysis KW - Sensors KW - Energy KW - Health Y1 - 2015 U6 - https://doi.org/10.1002/ejic.201402490 SN - 1434-1948 SN - 1099-0682 IS - 7 SP - 1148 EP - 1159 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Schulz, Michael Karl T1 - Politics and Law: Perspective Series of German-Jewish History JF - German history : the journal of the German History Societ Y1 - 2015 SN - 0266-3554 SN - 1477-089X VL - 33 IS - 1 SP - 145 EP - 147 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Winst, Silke T1 - A Test to Narrate. Studies on Interpretation and contextualization of Charles's Literature 'Morant and Galie' JF - Beiträge zur Geschichte der deutschen Sprache und Literatur Y1 - 2015 U6 - https://doi.org/10.1515/bgsl-2015-0012 SN - 0005-8076 SN - 1865-9373 VL - 137 IS - 1 SP - 160 EP - 164 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Ong, Albert C. M. A1 - von Websky, Karoline A1 - Hocher, Berthold T1 - Endothelin and Tubulointerstitial Renal Disease JF - Seminars in nephrology N2 - All components of the endothelin (ET) system are present in renal tubular cells. In this review, we summarize current knowledge about ET and the most common tubular diseases: acute kidney injury (AKI) and polycystic kidney disease. AKI originally was called acute tubular necrosis, pointing to the most prominent morphologic findings. Similarly, cysts in polycystic kidney disease, and especially in autosomal-dominant polycystic kidney disease, are of tubular origin. Preclinical studies have indicated that the ET system and particularly ETA receptors are involved in the pathogenesis of ischemia-reperfusion injury, although these findings have not been translated to clinical studies. The ET system also has been implicated in radiocontrast-dye-induced AKI, however, ET-receptor blockade in a large human study was not successful. The ET system is activated in sepsis models of AKI; the effectiveness of ET blocking agents in preclinical studies is variable depending on the model and the ET-receptor antagonist used. Numerous studies have shown that the ET system plays an important role in the complex pathophysiology associated with cyst formation and disease progression in polycystic kidney disease. However, results from selective targeting of ET-receptor subtypes in animal models of polycystic kidney disease have proved disappointing and do not support clinical trials. These studies have shown that a critical balance between ETA and ETB receptor action is necessary to maintain structure and function in the cystic kidney. In summary, ETs have been implicated in the pathogenesis of several renal tubulointerstitial diseases, however, experimental animal findings have not yet led to use of ET blockers in human beings. (C) 2015 Elsevier Inc. All rights reserved. KW - Endothelin KW - acute kidney injury KW - polycystic kidney disease KW - ADPKD KW - ET-1 KW - ETA KW - ETB Y1 - 2015 U6 - https://doi.org/10.1016/j.semnephrol.2015.03.004 SN - 0270-9295 SN - 1558-4488 VL - 35 IS - 2 SP - 197 EP - 207 PB - Elsevier CY - Philadelphia ER -