TY  - JOUR
A1  - Dietrich, Stefan
A1  - Jacobs, Simone
A1  - Zheng, Ju-Sheng
A1  - Meidtner, Karina
A1  - Schwingshackl, Lukas
A1  - Schulze, Matthias Bernd
T1  - Gene-lifestyle interaction on risk of type 2 diabetes
BT  - A systematic review
JF  - Obesity reviews : an official journal of the International Association for the Study of Obesity
N2  - The pathophysiological influence of gene-lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene-lifestyle interactions regarding T2D incidence. MEDLINE, EMBASE, and Web of Science were systematically searched until 31 January 2019 to identify publication with (a) prospective study design; (b) T2D incidence; (c) gene-diet, gene-physical activity, and gene-weight loss intervention interaction; and (d) population who are healthy or prediabetic. Of 66 eligible publications, 28 reported significant interactions. A variety of different genetic variants and dietary factors were studied. Variants at TCF7L2 were most frequently investigated and showed interactions with fiber and whole grain on T2D incidence. Further gene-diet interactions were reported for, eg, a western dietary pattern with a T2D-GRS, fat and carbohydrate with IRS1 rs2943641, and heme iron with variants of HFE. Physical activity showed interaction with HNF1B, IRS1, PPAR gamma, ADRA2B, SLC2A2, and ABCC8 variants and weight loss interventions with ENPP1, PPAR gamma, ADIPOR2, ADRA2B, TNF alpha, and LIPC variants. However, most findings represent single study findings obtained in European ethnicities. Although some interactions have been reported, their conclusiveness is still low, as most findings were not yet replicated across multiple study populations.
KW  - diet
KW  - gene-lifestyle interaction
KW  - incident type 2 diabetes
KW  - physical activity
KW  - weight loss intervention
Y1  - 2019
U6  - https://doi.org/10.1111/obr.12921
SN  - 1467-7881
SN  - 1467-789X
VL  - 20
IS  - 11
SP  - 1557
EP  - 1571
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Borde, Ron
A1  - Smith, Jordan J.
A1  - Sutherland, Rachel
A1  - Nathan, Nicole
A1  - Lubans, David Revalds
T1  - Methodological considerations and impact of school-based interventions on objectively measured physical activity in adolescents: a systematic review and meta-analysis
JF  - Obesity reviews : an official journal of the International Association for the Study of Obesity
N2  - Objective: The aims of this systematic review and meta-analysis are (i) to determine the impact of school-based interventions on objectively measured physical activity among adolescents and (ii) to examine accelerometer methods and decision rule reporting in previous interventions. Methods: A systematic search was performed to identify randomized controlled trials targeting adolescents (age: >= 10 years), conducted in the school setting, and reporting objectively measured physical activity. Random effects meta-analyses were conducted to determine the pooled effects of previous interventions on total and moderate-to-vigorous physical activity. Potential moderators of intervention effects were also explored. Results: Thirteen articles met the inclusion criteria, and twelve were included in the meta-analysis. The pooled effects were small and non-significant for both total physical activity (standardized mean difference = 0.02 [95% confidence interval = -0.13 to 0.18]) and moderate-to-vigorous physical activity (standardized mean difference = 0.24 [95% confidence interval = -0.08 to 0.56]). Sample age and accelerometer compliance were significant moderators for total physical activity, with a younger sample and higher compliance associated with larger effects. Conclusion: Previous school-based physical activity interventions targeting adolescents have been largely unsuccessful, particularly for older adolescents. There is a need for more high-quality research using objective monitoring in this population. Future interventions should comply with best-practice recommendations regarding physical activity monitoring protocols.
KW  - Accelerometer
KW  - physical activity
KW  - school
KW  - youth
Y1  - 2017
U6  - https://doi.org/10.1111/obr.12517
SN  - 1467-7881
SN  - 1467-789X
VL  - 18
SP  - 476
EP  - 490
PB  - Wiley
CY  - Hoboken
ER  -