TY - JOUR A1 - Unterhuber, Angelika A1 - Povazay, B. A1 - Bizheva, K. A1 - Hermann, B. A1 - Sattmann, Harald A1 - Stingl, A. A1 - Le, Trang A1 - Seefeldt, Michael A1 - Menzel, Ralf A1 - Preusser, Matthias A1 - Budka, Herbert A1 - Schubert, Christian A1 - Reitsamer, H. A1 - Ahnelt, Peter Kurt A1 - Morgan, J. E. T1 - Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography N2 - Novel ultra-broad bandwidth light sources enabling unprecedented sub-2 pm axial resolution over the 400 nm-1700 nm wavelength range have been developed and evaluated with respect to their feasibility for clinical ultrahigh resolution optical coherence tomography (UHR OCT) applications. The state-of-the-art light sources described here include a compact Kerr lens mode locked Ti:sapphire laser (lambda(c) = 785 nm, Deltalambda = 260 nm, P-out = 50 mW) and different nonlinear fibre-based light sources with spectral bandwidths (at full width at half maximum) up to 350 nm at lambda(c) = 1130 nm and 470 nm at lambda(c) = 1375 run. In vitro UHR OCT imaging is demonstrated at multiple wavelengths in human cancer cells, animal ganglion cells as well as in neuropathologic and ophthalmic biopsies in order to compare and optimize UHR OCT image contrast, resolution and penetration depth Y1 - 2004 SN - 0031-9155 ER -