TY - BOOK A1 - Görtemaker, Manfred T1 - Rudolf Hess : der Stellvertreter BT - eine Biographie N2 - Welch ein Anblick für die Welt", notierte Joseph Goebbels geschockt in seinem Tagebuch. "Ein geistig zerrütteter zweiter Mann nach dem Führer. Grauenhaft und unausdenkbar." Da war Rudolf Hess soeben zu seinem mysteriösen Flug nach England aufgebrochen, um im Alleingang Frieden zu stiften. Wer war dieser von Rätseln umgebene Mann, der wie ein Schatten Hitlers wirkte, in Nürnberg zu lebenslanger Haft verurteilt wurde und nach seinem Tod in Spandau zu einer Ikone der Neonazis werden sollte? Manfred Görtemaker legt die erste grundlegende Biographie vor, die mit neuen Quellen einen präzisen Einblick in die Chefetage des NS-Regimes ermöglicht. Der Potsdamer Zeithistoriker Manfred Görtemaker hat fast zwanzig Jahre lang an dieser akribisch recherchierten Biographie gearbeitet. Erstmals konnte er ca. 4.100 Briefe und 50.000 Blatt Schriftwechsel aus dem Hess-Nachlass im Berner Bundesarchiv auswerten, mit einer Sondergenehmigung die Papiere von Lord Selkirk of Douglas, dem Sohn des Duke of Hamilton, zu dem Hess nach Schottland flog, einsehen sowie eine beeindruckende Zahl von weiteren bislang unerschlossenen Archivalien heranziehen. Das Resultat ist das Lebensbild des Mannes, der von Anfang an mit Hitler durch dick und dünn ging, dessen wachsende Machtfülle wie ein Alter Ego verwaltete und über dessen Einfluss als "Stellvertreter des Führers" sich kein Rivale Illusionen machte. Manfred Görtemaker konnte als Erster Briefe und Schriften aus dem Nachlass von Rudolf Hess auswerten Hitlers treuester Paladin in einer präzisen biographischen Rekonstruktion Eine exemplarische Studie darüber, wie jemand zum Nazi wird Y1 - 2023 SN - 978-3-406-65291-2 SN - 978-3-406-65292-9 PB - C.H. Beck, CY - München ER - TY - BOOK ED - McNamara, James ED - Pagán, Victoria Emma T1 - Tacitus' Wonders BT - empire and paradox in ancient Rome N2 - This volume approaches the broad topic of wonder in the works of Tacitus, encompassing paradox, the marvellous and the admirable. Recent scholarship on these themes in Roman literature has tended to focus on poetic genres, with comparatively little attention paid to historiography: Tacitus, whose own judgments on what is worthy of note have often differed in interesting ways from the preoccupations of his readers, is a fascinating focal point for this complementary perspective. Scholarship on Tacitus has to date remained largely marked by a divide between the search for veracity – as validated by modern historiographical standards – and literary approaches, and as a result wonders have either been ignored as unfit for an account of history or have been deprived of their force by being interpreted as valid only within the text. While the modern ideal of historiographical objectivity tends to result in striving for consistent heuristic and methodological frameworks, works as varied as Tacitus' Histories, Annals and opera minora can hardly be prefaced with a statement of methodology broad enough to escape misrepresenting their diversity. In our age of specialization a streamlined methodological framework is a virtue, but it should not be assumed that Tacitus had similar priorities, and indeed the Histories and Annals deserve to be approached with openness towards the variety of perspectives that a tradition as rich as Latin historiographical prose can include within its scope. This collection proposes ways to reconcile the divide between history and historiography by exploring contestable moments in the text that challenge readers to judge and interpret for themselves, with individual chapters drawing on a range of interpretive approaches that mirror the wealth of authorial and reader-specific responses in play. KW - Tacitus KW - Paradoxography KW - Historiography KW - Ancient Rome KW - Latin literature KW - Paradoxographie KW - Geschichtsschreibung KW - Alte Geschichte KW - Lateinische Literatur Y1 - 2022 SN - 978-1-350-24172-5 SN - 978-1-350-24175-6 PB - Bloomsbury CY - London ER - TY - JOUR A1 - Pilz, Marco A1 - Isken, Marius Paul A1 - Fleming, Kevin A1 - Orunbaev, Sagynbek A1 - Moldobekov, Bolot T1 - Long- and short-term monitoring of a dam in response to seasonal changes and ground motion loading BT - the test case of the Kurpsai Dam, Western Kyrgyz Republic JF - Pure and applied geophysics : PAGEOPH ; continuation of Geofisica pura e applicata N2 - An experimental multi-parameter structural monitoring system has been installed on the Kurpsai dam, western Kyrgyz Republic. This system consists of equipment for seismic and strain measurements for making longer- (days, weeks, months) and shorter- (minutes, hours) term observations, dealing with, for example seasonal (longer) effects or the response of the dam to ground motion from noise or seismic events. Fibre-optic strain sensors allow the seasonal and daily opening and closing of the spaces between the dam's segments to be tracked. For the seismic data, both amplitude (in terms of using differences in amplitudes in the Fourier spectra for mapping the modes of vibration of the dam) and their time-frequency distribution for a set of small to moderate seismic events are investigated and the corresponding phase variabilities (in terms of lagged coherency) are evaluated. Even for moderate levels of seismic-induced ground motion, some influence on the structural response can be detected, which then sees the dam quickly return to its original state. A seasonal component was identified in the strain measurements, while levels of noise arising from the operation of the dam's generators and associated water flow have been provisionally identified. KW - Structural health monitoring KW - Dam engineering KW - Operational and environmental effects KW - Strong-motion KW - Strain KW - Elastic response KW - Kurpsai dam Y1 - 2021 U6 - https://doi.org/10.1007/s00024-021-02861-5 SN - 0033-4553 SN - 1420-9136 VL - 178 IS - 10 SP - 4001 EP - 4020 PB - Birkhäuser CY - Basel ER - TY - JOUR A1 - McNamara, James ED - Geue, Tom ED - Giusti, Elena T1 - Lost in Germania BT - the absence of history in Tacitus' ethnography JF - Unspoken Rome: Absences in Latin Texts N2 - Tacitus’ Germania is notable for its absences: lacking a preface and programmatic statements, and being the only ethnographic monograph to have survived from Greco-Roman antiquity, readers have often leapt to fill in its perceived blanks. This chapter aims at redressing the effects of overdetermined readings by interpreting the text’s absences as significant in their own right. KW - Tacitus KW - Germania KW - Ethnography KW - Ethnographie KW - Historiography KW - Geschichtsschreibung KW - Absence KW - Latin literature KW - Lateinische Literatur Y1 - 2021 UR - https://www.cambridge.org/core/books/unspoken-rome/lost-in-germania/14769D9F862EC2E2868152BFF0B3D78D SN - 978-11-0884-304-1 U6 - https://doi.org/https://doi.org/10.1017/9781108913843.012 SP - 201 EP - 218 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Vasyura-Bathke, Hannes A1 - Dettmer, Jan A1 - Dutta, Rishabh A1 - Mai, Paul Martin A1 - Jónsson, Sigurjón T1 - Accounting for theory errors with empirical Bayesian noise models in nonlinear centroid moment tensor estimation JF - Geophysical journal international / the Royal Astronomical Society, the Deutsche Geophysikalische Gesellschaft and the European Geophysical Society N2 - Centroid moment tensor (CMT) parameters can be estimated from seismic waveforms. Since these data indirectly observe the deformation process, CMTs are inferred as solutions to inverse problems which are generally underdetermined and require significant assumptions, including assumptions about data noise. Broadly speaking, we consider noise to include both theory and measurement errors, where theory errors are due to assumptions in the inverse problem and measurement errors are caused by the measurement process. While data errors are routinely included in parameter estimation for full CMTs, less attention has been paid to theory errors related to velocity-model uncertainties and how these affect the resulting moment-tensor (MT) uncertainties. Therefore, rigorous uncertainty quantification for CMTs may require theory-error estimation which becomes a problem of specifying noise models. Various noise models have been proposed, and these rely on several assumptions. All approaches quantify theory errors by estimating the covariance matrix of data residuals. However, this estimation can be based on explicit modelling, empirical estimation and/or ignore or include covariances. We quantitatively compare several approaches by presenting parameter and uncertainty estimates in nonlinear full CMT estimation for several simulated data sets and regional field data of the M-1 4.4, 2015 June 13 Fox Creek, Canada, event. While our main focus is at regional distances, the tested approaches are general and implemented for arbitrary source model choice. These include known or unknown centroid locations, full MTs, deviatoric MTs and double-couple MTs. We demonstrate that velocity-model uncertainties can profoundly affect parameter estimation and that their inclusion leads to more realistic parameter uncertainty quantification. However, not all approaches perform equally well. Including theory errors by estimating non-stationary (non-Toeplitz) error covariance matrices via iterative schemes during Monte Carlo sampling performs best and is computationally most efficient. In general, including velocity-model uncertainties is most important in cases where velocity structure is poorly known. KW - Inverse theory KW - Probability distributions KW - Waveform inversion KW - Earthquake source observations KW - Seismic noise Y1 - 2021 U6 - https://doi.org/10.1093/gji/ggab034 SN - 0956-540X SN - 1365-246X VL - 225 IS - 2 SP - 1412 EP - 1431 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Ostermann-Miyashita, Emu-Felicitas A1 - König, Hannes J. A1 - Pernat, Nadja A1 - Bellingrath-Kimura, Sonoko Dorothea A1 - Hibler, Sophia A1 - Kiffner, Christian T1 - Knowledge of returning wildlife species and willingness to participate in citizen science projects among wildlife park visitors in Germany JF - People and nature N2 - Successful conservation efforts have led to recent increases of large mammals such as European bison Bison bonasus, moose Alces alces and grey wolf Canis lupus and their return to former habitats in central Europe. While embraced by some, the recovery of these species is a controversial topic and holds potential for human-wildlife conflicts. Involving the public has been suggested to be an effective method for monitoring wildlife and mitigating associated conflicts. To assess two interrelated prerequisites for engaging people in Citizen Science (CS)-knowledge of returning species and respondents' readiness to participate in CS activities for monitoring and managing these species-we conducted a survey (questionnaire) in two wildlife parks located in different states of Germany. Based on 472 complete questionnaires, we developed generalized linear models to understand how sociodemographic variables and exposure to the species affected visitors' knowledge of each species, and to investigate if sociodemographic variables and knowledge influenced the likelihood of visitors to participate in CS activities. Almost all visitors were aware of the returning wolf population, while knowledge and awareness about bison and moose were significantly lower. Knowledge of the two herbivores differed geographically (higher knowledge of moose in the north-eastern state), possibly indicating a positive association between exposure to the species and knowledge. However, models generally performed poorly in predicting knowledge about wildlife, suggesting that such specific knowledge is insufficiently explained by sociodemographic variables. Our model, which explained stated willingness in CS indicated that younger participants and those with higher knowledge scores in the survey were more willing to engage in CS activities. Overall, our analyses highlight how exposure to large mammals, knowledge about wildlife and human demographics are interrelated-insights that are helpful for effectively recruiting citizen scientists for wildlife conservation. Read the free Plain Language Summary for this article on the Journal blog. KW - environmental awareness KW - human-animal relationships KW - human-wildlife conflicts KW - social-ecological system KW - wildlife conservation KW - wildlife knowledge Y1 - 2022 U6 - https://doi.org/10.1002/pan3.10379 SN - 2575-8314 VL - 4 IS - 5 SP - 1201 EP - 1215 PB - British Ecological Society; Wiley CY - London; Hoboken, NJ ER - TY - JOUR A1 - Andjelković, Marko A1 - Chen, Junchao A1 - Simevski, Aleksandar A1 - Schrape, Oliver A1 - Krstić, Miloš A1 - Kraemer, Rolf T1 - Monitoring of particle count rate and LET variations with pulse stretching inverters JF - IEEE transactions on nuclear science : a publication of the IEEE Nuclear and Plasma Sciences Society N2 - This study investigates the use of pulse stretching (skew-sized) inverters for monitoring the variation of count rate and linear energy transfer (LET) of energetic particles. The basic particle detector is a cascade of two pulse stretching inverters, and the required sensing area is obtained by connecting up to 12 two-inverter cells in parallel and employing the required number of parallel arrays. The incident particles are detected as single-event transients (SETs), whereby the SET count rate denotes the particle count rate, while the SET pulsewidth distribution depicts the LET variations. The advantage of the proposed solution is the possibility to sense the LET variations using fully digital processing logic. SPICE simulations conducted on IHP's 130-nm CMOS technology have shown that the SET pulsewidth varies by approximately 550 ps over the LET range from 1 to 100 MeV center dot cm(2) center dot mg(-1). The proposed detector is intended for triggering the fault-tolerant mechanisms within a self-adaptive multiprocessing system employed in space. It can be implemented as a standalone detector or integrated in the same chip with the target system. KW - Particle detector KW - pulse stretching inverters KW - single-event transient KW - (SET) count rate KW - SET pulsewidth distribution Y1 - 2021 U6 - https://doi.org/10.1109/TNS.2021.3076400 SN - 0018-9499 SN - 1558-1578 VL - 68 IS - 8 SP - 1772 EP - 1781 PB - Institute of Electrical and Electronics Engineers CY - New York, NY ER - TY - JOUR A1 - Scharnweber, Inga Kristin A1 - Chaguaceda, Fernando A1 - Eklöv, Peter T1 - Fatty acid accumulation in feeding types of a natural freshwater fish population JF - Oecologia / in cooperation with the International Association for Ecology, Intecol N2 - Fatty acids are widely used to study trophic interactions in food web assemblages. Generally, it is assumed that there is a very small modification of fatty acids from one trophic step to another, making them suitable as trophic biomarkers. However, recent literature provides evidence that many fishes possess genes encoding enzymes with a role in bioconversion, thus the capability for bioconversion might be more widespread than previously assumed. Nonetheless, empirical evidence for biosynthesis occurring in natural populations remains scarce. In this study, we investigated different feeding types of perch (Perca fluviatilis) that are specialized on specific resources with different levels of highly unsaturated fatty acids (HUFAs), and analyzed the change between HUFA proportions in perch muscle tissue compared to their resources. Perch showed matching levels to their resources for EPA, but ARA and especially DHA were accumulated. Compound-specific stable isotope analyses helped us to identify the origin of HUFA carbon. Our results suggest that perch obtain a substantial amount of DHA via bioconversion when feeding on DHA-poor benthic resources. Thus, our data indicate the capability of bioconversion of HUFAs in a natural freshwater fish population. KW - Fatty acid conversion KW - Compound-specific stable isotope analysis KW - Docosahexaenoic acid KW - Bioconversion KW - Trophic upgrading Y1 - 2021 U6 - https://doi.org/10.1007/s00442-021-04913-y SN - 0029-8549 SN - 1432-1939 VL - 196 IS - 1 SP - 53 EP - 63 PB - Springer CY - Berlin ; Heidelberg [u.a.] ER - TY - JOUR A1 - Schlosser, Rainer A1 - Chenavaz, Régis Y. A1 - Dimitrov, Stanko T1 - Circular economy BT - joint dynamic pricing and recycling investments JF - International journal of production economics N2 - In a circular economy, the use of recycled resources in production is a key performance indicator for management. Yet, academic studies are still unable to inform managers on appropriate recycling and pricing policies. We develop an optimal control model integrating a firm's recycling rate, which can use both virgin and recycled resources in the production process. Our model accounts for recycling influence both at the supply- and demandsides. The positive effect of a firm's use of recycled resources diminishes over time but may increase through investments. Using general formulations for demand and cost, we analytically examine joint dynamic pricing and recycling investment policies in order to determine their optimal interplay over time. We provide numerical experiments to assess the existence of a steady-state and to calculate sensitivity analyses with respect to various model parameters. The analysis shows how to dynamically adapt jointly optimized controls to reach sustainability in the production process. Our results pave the way to sounder sustainable practices for firms operating within a circular economy. KW - Dynamic pricing KW - Recycling investments KW - Optimal control KW - General demand function KW - Circular economy Y1 - 2021 U6 - https://doi.org/10.1016/j.ijpe.2021.108117 SN - 0925-5273 SN - 1873-7579 VL - 236 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Nakoudi, Konstantina A1 - Ritter, Christoph A1 - Stachlewska, Iwona S. T1 - Properties of cirrus clouds over the European Arctic (Ny-Alesund, Svalbard) JF - Remote sensing / Molecular Diversity Preservation International (MDPI) N2 - Cirrus is the only cloud type capable of inducing daytime cooling or heating at the top of the atmosphere (TOA) and the sign of its radiative effect highly depends on its optical depth. However, the investigation of its geometrical and optical properties over the Arctic is limited. In this work the long-term properties of cirrus clouds are explored for the first time over an Arctic site (Ny-Alesund, Svalbard) using lidar and radiosonde measurements from 2011 to 2020. The optical properties were quality assured, taking into account the effects of specular reflections and multiple-scattering. Cirrus clouds were generally associated with colder and calmer wind conditions compared to the 2011-2020 climatology. However, the dependence of cirrus properties on temperature and wind speed was not strong. Even though the seasonal cycle was not pronounced, the winter-time cirrus appeared under lower temperatures and stronger wind conditions. Moreover, in winter, geometrically- and optically-thicker cirrus were found and their ice particles tended to be more spherical. The majority of cirrus was associated with westerly flow and westerly cirrus tended to be geometrically-thicker. Overall, optically-thinner layers tended to comprise smaller and less spherical ice crystals, most likely due to reduced water vapor deposition on the particle surface. Compared to lower latitudes, the cirrus layers over Ny-Alesund were more absorbing in the visible spectral region and they consisted of more spherical ice particles. KW - Arctic clouds KW - cirrus clouds KW - ice clouds KW - lidar Y1 - 2021 U6 - https://doi.org/10.3390/rs13224555 SN - 2072-4292 VL - 13 IS - 22 PB - MDPI CY - Basel ER - TY - JOUR A1 - Tscheuschner, Georg A1 - Kaiser, Melanie N. A1 - Lisec, Jan A1 - Beslic, Denis A1 - Muth, Thilo A1 - Krüger, Maren A1 - Mages, Hans Werner A1 - Dorner, Brigitte G. A1 - Knospe, Julia A1 - Schenk, Jörg A. A1 - Sellrie, Frank A1 - Weller, Michael G. T1 - MALDI-TOF-MS-based identification of monoclonal murine Anti-SARS-CoV-2 antibodies within one hour JF - Antibodies N2 - During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines the importance of antibodies as universal bioanalytical reagents. However, little attention is given to the reproducibility crisis that scientific studies are still facing to date. In a recent study, not even half of all research antibodies mentioned in publications could be identified at all. This should spark more efforts in the search for practical solutions for the traceability of antibodies. For this purpose, we used 35 monoclonal antibodies against SARS-CoV-2 to demonstrate how sequence-independent antibody identification can be achieved by simple means applied to the protein. First, we examined the intact and light chain masses of the antibodies relative to the reference material NIST-mAb 8671. Already half of the antibodies could be identified based solely on these two parameters. In addition, we developed two complementary peptide mass fingerprinting methods with MALDI-TOF-MS that can be performed in 60 min and had a combined sequence coverage of over 80%. One method is based on the partial acidic hydrolysis of the protein by 5 mM of sulfuric acid at 99 degrees C. Furthermore, we established a fast way for a tryptic digest without an alkylation step. We were able to show that the distinction of clones is possible simply by a brief visual comparison of the mass spectra. In this work, two clones originating from the same immunization gave the same fingerprints. Later, a hybridoma sequencing confirmed the sequence identity of these sister clones. In order to automate the spectral comparison for larger libraries of antibodies, we developed the online software ABID 2.0. This open-source software determines the number of matching peptides in the fingerprint spectra. We propose that publications and other documents critically relying on monoclonal antibodies with unknown amino acid sequences should include at least one antibody fingerprint. By fingerprinting an antibody in question, its identity can be confirmed by comparison with a library spectrum at any time and context. KW - SARS-CoV-2 antibody KW - reproducibility crisis KW - peptide mass KW - fingerprinting KW - monoclonal antibody KW - traceability KW - identity KW - antibody KW - identification KW - antibody light chain KW - MALDI-TOF-MS Y1 - 2022 U6 - https://doi.org/10.3390/antib11020027 SN - 2073-4468 VL - 11 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Leins, Johannes A. A1 - Banitz, Thomas A1 - Grimm, Volker A1 - Drechsler, Martin T1 - High-resolution PVA along large environmental gradients to model the combined effects of climate change and land use timing BT - lessons from the large marsh grasshopper JF - Ecological modelling : international journal on ecological modelling and systems ecology N2 - Both climate change and land use regimes affect the viability of populations, but they are often studied separately. Moreover, population viability analyses (PVAs) often ignore the effects of large environmental gradients and use temporal resolutions that are too coarse to take into account that different stages of a population's life cycle may be affected differently by climate change. Here, we present the High-resolution Large Environmental Gradient (HiLEG) model and apply it in a PVA with daily resolution based on daily climate projections for Northwest Germany. We used the large marsh grasshopper (LMG) as the target species and investigated (1) the effects of climate change on the viability and spatial distribution of the species, (2) the influence of the timing of grassland mowing on the species and (3) the interaction between the effects of climate change and grassland mowing. The stageand cohort-based model was run for the spatially differentiated environmental conditions temperature and soil moisture across the whole study region. We implemented three climate change scenarios and analyzed the population dynamics for four consecutive 20-year periods. Climate change alone would lead to an expansion of the regions suitable for the LMG, as warming accelerates development and due to reduced drought stress. However, in combination with land use, the timing of mowing was crucial, as this disturbance causes a high mortality rate in the aboveground life stages. Assuming the same date of mowing throughout the region, the impact on viability varied greatly between regions due to the different climate conditions. The regional negative effects of the mowing date can be divided into five phases: (1) In early spring, the populations were largely unaffected in all the regions; (2) between late spring and early summer, they were severely affected only in warm regions; (3) in summer, all the populations were severely affected so that they could hardly survive; (4) between late summer and early autumn, they were severely affected in cold regions; and (5) in autumn, the populations were equally affected across all regions. The duration and start of each phase differed slightly depending on the climate change scenario and simulation period, but overall, they showed the same pattern. Our model can be used to identify regions of concern and devise management recommendations. The model can be adapted to the life cycle of different target species, climate projections and disturbance regimes. We show with our adaption of the HiLEG model that high-resolution PVAs and applications on large environmental gradients can be reconciled to develop conservation strategies capable of dealing with multiple stressors. KW - Climate change KW - Land use KW - Population viability analysis KW - Stage-based model KW - High resolution KW - Environmental gradients Y1 - 2020 U6 - https://doi.org/10.1016/j.ecolmodel.2020.109355 SN - 0304-3800 VL - 440 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Potente, Giacomo A1 - Léveillé-Bourret, Étienne A1 - Yousefi, Narjes A1 - Choudhury, Rimjhim Roy A1 - Keller, Barbara A1 - Diop, Seydina Issa A1 - Duijsings, Daniël A1 - Pirovano, Walter A1 - Lenhard, Michael A1 - Szövényi, Péter A1 - Conti, Elena T1 - Comparative genomics elucidates the origin of a supergene controlling floral heteromorphism JF - Molecular biology and evolution : MBE N2 - Supergenes are nonrecombining genomic regions ensuring the coinheritance of multiple, coadapted genes. Despite the importance of supergenes in adaptation, little is known on how they originate. A classic example of supergene is the S locus controlling heterostyly, a floral heteromorphism occurring in 28 angiosperm families. In Primula, heterostyly is characterized by the cooccurrence of two complementary, self-incompatible floral morphs and is controlled by five genes clustered in the hemizygous, ca. 300-kb S locus. Here, we present the first chromosome-scale genome assembly of any heterostylous species, that of Primula veris (cowslip). By leveraging the high contiguity of the P. veris assembly and comparative genomic analyses, we demonstrated that the S-locus evolved via multiple, asynchronous gene duplications and independent gene translocations. Furthermore, we discovered a new whole-genome duplication in Ericales that is specific to the Primula lineage. We also propose a mechanism for the origin of S-locus hemizygosity via nonhomologous recombination involving the newly discovered two pairs of CFB genes flanking the S locus. Finally, we detected only weak signatures of degeneration in the S locus, as predicted for hemizygous supergenes. The present study provides a useful resource for future research addressing key questions on the evolution of supergenes in general and the S locus in particular: How do supergenes arise? What is the role of genome architecture in the evolution of complex adaptations? Is the molecular architecture of heterostyly supergenes across angiosperms similar to that of Primula? KW - genome architecture KW - supergene KW - heterostyly KW - evolutionary genomics KW - chromosome-scale genome assembly KW - primula Y1 - 2022 U6 - https://doi.org/10.1093/molbev/msac035 SN - 0737-4038 SN - 1537-1719 VL - 39 IS - 2 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Konigorski, Stefan A1 - Wernicke, Sarah A1 - Slosarek, Tamara A1 - Zenner, Alexander M. A1 - Strelow, Nils A1 - Ruether, Darius F. A1 - Henschel, Florian A1 - Manaswini, Manisha A1 - Pottbäcker, Fabian A1 - Edelman, Jonathan A. A1 - Owoyele, Babajide A1 - Danieletto, Matteo A1 - Golden, Eddye A1 - Zweig, Micol A1 - Nadkarni, Girish N. A1 - Böttinger, Erwin T1 - StudyU: a platform for designing and conducting innovative digital N-of-1 trials JF - Journal of medical internet research N2 - N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive personalized treatment strategies. Digital tools have the potential to initiate a new era of N-of-1 trials in terms of scale and scope, but fully functional platforms are not yet available. Here, we present the open source StudyU platform, which includes the StudyU Designer and StudyU app. With the StudyU Designer, scientists are given a collaborative web application to digitally specify, publish, and conduct N-of-1 trials. The StudyU app is a smartphone app with innovative user-centric elements for participants to partake in trials published through the StudyU Designer to assess the effects of different interventions on their health. Thereby, the StudyU platform allows clinicians and researchers worldwide to easily design and conduct digital N-of-1 trials in a safe manner. We envision that StudyU can change the landscape of personalized treatments both for patients and healthy individuals, democratize and personalize evidence generation for self-optimization and medicine, and can be integrated in clinical practice. KW - digital interventions KW - N-of-1 trial KW - SCED KW - single-case experimental design KW - web application KW - mobile application KW - app KW - digital health Y1 - 2022 U6 - https://doi.org/10.2196/35884 SN - 1439-4456 SN - 1438-8871 VL - 24 IS - 7 PB - Healthcare World CY - Richmond, Va. ER - TY - JOUR A1 - Lucena-Perez, María A1 - Bazzicalupo, Enrico A1 - Paijmans, Johanna A1 - Kleinman-Ruiz, Daniel A1 - Dalén, Love A1 - Hofreiter, Michael A1 - Delibes, Miguel A1 - Clavero, Miguel A1 - Godoy, José A. T1 - Ancient genome provides insights into the history of Eurasian lynx in Iberia and Western Europe JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - The Eurasian lynx (Lynx lynx) is one of the most widely distributed felids in the world. However, most of its populations started to decline a few millennia ago. Historical declines have been especially severe in Europe, and particularly in Western Europe, from where the species disappeared in the last few centuries. Here, we analyze the genome of an Eurasian lynx inhabiting the Iberian Peninsula 2500 ya, to gain insights into the phylogeographic position and genetic status of this extinct population. Also, we contextualize previous ancient data in the light of new phylogeographic studies of the species. Our results suggest that the Iberian population is part of an extinct European lineage closely related to the current Carpathian-Baltic lineages. Also, this sample holds the lowest diversity reported for the species so far, and similar to that of the highly endangered Iberian lynx. A combination of historical factors, such as a founder effect while colonizing the peninsula, together with intensified human impacts during the Holocene in the Cantabrian strip, could have led to a genetic impoverishment of the population and precipitated its extinction. Mitogenomic lineages distribution in space and time support the long-term coexistence of several lineages of Eurasian lynx in Western Europe with fluctuating ranges. While mitochondrial sequences related to the lineages currently found in Balkans and Caucasus were predominant during the Pleistocene, those more closely related to the lineage currently distributed in Central Europe prevailed during the Holocene. The use of ancient genomics has proven to be a useful tool to understand the biogeographic pattern of the Eurasian lynx in the past. Y1 - 2022 U6 - https://doi.org/10.1016/j.quascirev.2022.107518 SN - 0277-3791 SN - 1873-457X VL - 285 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Kreuzer, Lucas A1 - Widmann, Tobias A1 - Geiger, Christina A1 - Wang, Peixi A1 - Vagias, Apostolos N. A1 - Heger, Julian Eliah A1 - Haese, Martin A1 - Hildebrand, Viet A1 - Laschewsky, André A1 - Papadakis, Christine M. A1 - Müller-Buschbaum, Peter T1 - Salt-dependent phase transition behavior of doubly thermoresponsive poly(sulfobetaine)-based diblock copolymer thin films JF - Langmuir : the ACS journal of surfaces and colloids / American Chemical Society N2 - The water vapor-induced swelling, as well as subsequent phase-transition kinetics, of thin films of a diblock copolymer (DBC) loaded with different amounts of the salt NaBr, is investigated in situ. In dilute aqueous solution, the DBC features an orthogonally thermoresponsive behavior. It consists of a zwitterionic poly(sulfobetaine) block, namely, poly(4-(N-(3'-methacrylamidopropyl)-N, N-dimethylammonio) butane-1-sulfonate) (PSBP), showing an upper critical solution temperature, and a nonionic block, namely, poly(N-isopropylmethacrylamide) (PNIPMAM), exhibiting a lower critical solution temperature. The swelling kinetics in D2O vapor at 15 degrees C and the phase transition kinetics upon heating the swollen film to 60 degrees C and cooling back to 15 degrees C are followed with simultaneous time-of-flight neutron reflectometry and spectral reflectance measurements. These are complemented by Fourier transform infrared spectroscopy. The collapse temperature of PNIPMAM and the swelling temperature of PSBP are found at lower temperatures than in aqueous solution, which is attributed to the high polymer concentration in the thin-film geometry. Upon inclusion of sub-stoichiometric amounts (relative to the monomer units) of NaBr in the films, the water incorporation is significantly increased. This increase is mainly attributed to a salting-in effect on the zwitterionic PSBP block. Whereas the addition of NaBr notably shifts the swelling temperature of PSBP to lower temperatures, the collapse temperature of PNIPMAM remains unaffected by the presence of salt in the films. Y1 - 2021 U6 - https://doi.org/10.1021/acs.langmuir.1c01342 SN - 0743-7463 SN - 1520-5827 VL - 37 IS - 30 SP - 9179 EP - 9191 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Tönjes, Ralf A1 - Fiore, Carlos E. A1 - Pereira da Silva, Tiago T1 - Coherence resonance in influencer networks JF - Nature Communications N2 - Complex networks are abundant in nature and many share an important structural property: they contain a few nodes that are abnormally highly connected (hubs). Some of these hubs are called influencers because they couple strongly to the network and play fundamental dynamical and structural roles. Strikingly, despite the abundance of networks with influencers, little is known about their response to stochastic forcing. Here, for oscillatory dynamics on influencer networks, we show that subjecting influencers to an optimal intensity of noise can result in enhanced network synchronization. This new network dynamical effect, which we call coherence resonance in influencer networks, emerges from a synergy between network structure and stochasticity and is highly nonlinear, vanishing when the noise is too weak or too strong. Our results reveal that the influencer backbone can sharply increase the dynamical response in complex systems of coupled oscillators. Influencer networks include a small set of highly-connected nodes and can reach synchrony only via strong node interaction. Tonjes et al. show that introducing an optimal amount of noise enhances synchronization of such networks, which may be relevant for neuroscience or opinion dynamics applications. Y1 - 2021 U6 - https://doi.org/10.1038/s41467-020-20441-4 SN - 2041-1723 VL - 12 IS - 1 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Becker, George D. A1 - D'Aloisio, Anson A1 - Christenson, Holly M. A1 - Zhu, Yongda A1 - Worseck, Gábor A1 - Bolton, James S. T1 - The mean free path of ionizing photons at 5 < z < 6 BT - evidence for rapid evolution near reionization JF - Monthly notices of the Royal Astronomical Society N2 - The mean free path of ionizing photons, lambda(mfp), is a key factor in the photoionization of the intergalactic medium (IGM). At z greater than or similar to 5, however, lambda(mfp) may be short enough that measurements towards QSOs are biased by the QSO proximity effect. We present new direct measurements of lambda(mfp) that address this bias and extend up to z similar to 6 for the first time. Our measurements at z similar to 5 are based on data from the Giant Gemini GMOS survey and new Keck LRIS observations of low-luminosity QSOs. At z similar to 6 we use QSO spectra from Keck ESI and VLT X-Shooter. We measure lambda(mfp) = 9.09(-1.28)(+1.62) proper Mpc and 0.75(-0.45)(+0.65) proper Mpc (68 percent confidence) at z = 5.1 and 6.0, respectively. The results at z = 5.1 are consistent with existing measurements, suggesting that bias from the proximity effect is minor at this redshift. At z = 6.0, however, we find that neglecting the proximity effect biases the result high by a factor of two or more. Our measurement at z = 6.0 falls well below extrapolations from lower redshifts, indicating rapid evolution in lambda(mfp) over 5 < z < 6. This evolution disfavours models in which reionization ended early enough that the IGM had time to fully relax hydrodynamically by z = 6, but is qualitatively consistent with models wherein reionization completed at z = 6 or even significantly later. Our mean free path results are most consistent with late reionization models wherein the IGM is still 20 percent neutral at z = 6, although our measurement at z = 6.0 is even lower than these models prefer. KW - intergalactic medium KW - quasars: absorption lines KW - cosmology: observations KW - dark ages KW - large-scale structure of Universe KW - reionization KW - first stars Y1 - 2021 U6 - https://doi.org/10.1093/mnras/stab2696 SN - 0035-8711 SN - 1365-2966 VL - 508 IS - 2 SP - 1853 EP - 1869 PB - Oxford Univ. Press CY - Oxford ER - TY - CHAP A1 - Botsch, Gideon T1 - Rechtsextremer Antisemitismus in Brandenburg T2 - Mit der Verfassung gegen Antisemitismus : Dokumentation des Fach-Symposiums an der Universität Potsdam Y1 - 2020 UR - https://www.stiftung-toleranz.de/wp-content/uploads/2020/11/Mit-der-Verfassung-gegen-den-AS_Kompendium-final.pdf SP - 14 EP - 19 PB - F. C. Flick Stiftung CY - Potsdam ER - TY - CHAP A1 - Botsch, Gideon ED - von Appen, Ralf ED - Hindrichs, Thorsten T1 - "Wann I’ denk wie’s früher war." BT - Nationalismus in der "postnationalen Konstellation" T2 - One nation under a groove - »Nation« als Kategorie populärer Musik N2 - The successful Austrian pop-musician Andreas Gabalier has devoted several of his songs to his Styrian homeland. Gabalier's work and performance has often been per-ceived as nationalist. When analyzing some of his lyrics, an astonishing observation can be made: Most references to the »homeland« are backward-looking. This article argues that the remarkable lack of a national »future« in Gabalier's work is charac-teristic for contemporary nationalist manifestations, not only in popular culture, but also in ideologies and politics. The article introduces a new typology of nationalist movements. With regard to the character of the related nation-state, three types are discussed: »constructive nationalism« whereby the nationalist movement strives for a future sovereign nation state; »maintaining nationalism« wherein a nation state already exists; and »reconstructive nationalism« where nationalists believe that the nation state has lost its independence, sovereignty, and freedom in the course of globalization and hope for a reconstruction. However, these types are defined here as »ideal types« in a Weberian sense and will hardly be found in their »pure« forms in history or social reality. Y1 - 2020 SN - 9783837655810 SN - 9783839455814 U6 - https://doi.org/10.14361/9783839455814 SP - 15 EP - 29 PB - transcript CY - Bielefeld ER -