TY  - JOUR
A1  - Liu, Junzhong
A1  - Feng, Lili
A1  - Gu, Xueting
A1  - Deng, Xian
A1  - Qiu, Qi
A1  - Li, Qun
A1  - Zhang, Yingying
A1  - Wang, Muyang
A1  - Deng, Yiwen
A1  - Wang, Ertao
A1  - He, Yuke
A1  - Bäurle, Isabel
A1  - Li, Jianming
A1  - Cao, Xiaofeng
A1  - He, Zuhua
T1  - An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis
JF  - Cell research
N2  - Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation.
KW  - Chromatin
KW  - Epigenetic memory
KW  - Epigenetics
KW  - Innate immunity
KW  - Plant signalling
Y1  - 2019
U6  - https://doi.org/10.1038/s41422-019-0145-8
SN  - 1001-0602
SN  - 1748-7838
VL  - 29
IS  - 5
SP  - 379
EP  - 390
PB  - Nature Publ. Group
CY  - London
ER  -