TY  - JOUR
A1  - Ruszkiewicz, Joanna
A1  - de Macedo, Gabriel Teixeira
A1  - Miranda-Vizuete, Antonio
A1  - Teixeira da Rocha, Joao B.
A1  - Bowman, Aaron B.
A1  - Bornhorst, Julia
A1  - Schwerdtle, Tanja
A1  - Aschner, Michael
T1  - The cytoplasmic thioredoxin system in Caenorhabditis elegans affords protection from methylmercury in an age-specific manner
JF  - Neurotoxicology : the interdisciplinary journal of effects to toxic substances on the nervous system
N2  - Methylmercury (MeHg) is an environmental pollutant linked to many neurological defects, especially in developing individuals. The thioredoxin (TRX) system is a key redox regulator affected by MeHg toxicity, however the mechanisms and consequences of MeHg-induced dysfunction are not completely understood. This study evaluated the role of the TRX system in C. elegans susceptibility to MeHg during development. Worms lacking or overexpressing proteins from the TRX family were exposed to MeHg for 1 h at different developmental stage: L1, L4 and adult. Worms without cytoplasmic thioredoxin system exhibited age-specific susceptibility to MeHg when compared to wild-type (wt). This susceptibility corresponded partially to decreased total glutathione (GSH) levels and enhanced degeneration of dopaminergic neurons. In contrast, the overexpression of the cytoplasmic system TRX-1/TRXR-1 did not provide substantial protection against MeHg. Moreover, transgenic worms exhibited decreased protein expression for cytoplasmic thioredoxin reductase (TRXR-1). Both mitochondrial thioredoxin system TRX-2/TRXR-2, as well as other thioredoxin-like proteins: TRX-3, TRX-4, TRX-5 did not show significant role in C. elegans resistance to MeHg. Based on the current findings, the cytoplasmic thioredoxin system TRX-1/TRXR-1 emerges as an important age-sensitive protectant against MeHg toxicity in C. elegans.
KW  - Methylmercury
KW  - Age
KW  - Development
KW  - C. elegans
KW  - Thioredoxin
KW  - Thioredoxin reductase
Y1  - 2018
U6  - https://doi.org/10.1016/j.neuro.2018.08.007
SN  - 0161-813X
SN  - 1872-9711
VL  - 68
SP  - 189
EP  - 202
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Baroni, Gabriele
A1  - Scheiffele, Lena
A1  - Schrön, Martin
A1  - Ingwersen, Joachim
A1  - Oswald, Sascha
T1  - Uncertainty, sensitivity and improvements in soil moisture estimation with cosmic-ray neutron sensing
JF  - Journal of hydrology
N2  - Cosmic-ray neutron sensing (CRNS) is a promising proximal soil sensing technique to estimate soil moisture at intermediate scale and high temporal resolution. However, the signal shows complex and non-unique response to all hydrogen pools near the land surface, providing some challenges for soil moisture estimation in practical applications. Aims of the study were 1) to assess the uncertainty of CRNS as a stand-alone approach to estimate volumetric soil moisture in cropped field 2) to identify the causes of this uncertainty 3) and possible improvements. Two experimental sites in Germany were equipped with a CRNS probe and point-scale soil moisture network. Additional monitoring activities were conducted during the crop growing season to characterize the soil-plant systems. This data is used to identify and quantify the different sources of uncertainty (factors). An uncertainty analysis, based on Monte Carlo approach, is applied to propagate these uncertainties to CRNS soil moisture estimations. In addition, a sensitivity analysis based on the Sobol’ method is performed to identify the most important factors explaining this uncertainty. Results show that CRNS soil moisture compares well to the soil moisture network when these point-scale values are weighted to account for the spatial sensitivity of the signal and other sources of hydrogen (lattice water and organic carbon) are added to the water content. However, the performance decreases when CRNS is considered as a stand-alone method to retrieve the actual (non-weighted) volumetric soil moisture. The support volume (penetration depth and radius) shows also a considerable uncertainty, especially in relatively dry soil moisture conditions. Four of the seven factors analyzed (the vertical soil moisture profile, bulk density, incoming neutron correction and the calibrated parameter N0) were found to play an important role. Among the possible improvements identified, a simple correction factor based on vertical point-scale soil moisture profiles shows to be a promising approach to account for the sensitivity of the CRNS signal to the upper soil layers.
KW  - Soil moisture
KW  - Cosmic-ray neutrons
KW  - Uncertainty analysis
KW  - Sensitivity analysis
Y1  - 2018
U6  - https://doi.org/10.1016/j.jhydrol.2018.07.053
SN  - 0022-1694
SN  - 1879-2707
VL  - 564
SP  - 873
EP  - 887
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - GEN
A1  - Blaesius, Thomas
A1  - Eube, Jan
A1  - Feldtkeller, Thomas
A1  - Friedrich, Tobias
A1  - Krejca, Martin Stefan
A1  - Lagodzinski, Julius Albert Gregor
A1  - Rothenberger, Ralf
A1  - Severin, Julius
A1  - Sommer, Fabian
A1  - Trautmann, Justin
T1  - Memory-restricted Routing With Tiled Map Data
T2  - 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC)
N2  - Modern routing algorithms reduce query time by depending heavily on preprocessed data. The recently developed Navigation Data Standard (NDS) enforces a separation between algorithms and map data, rendering preprocessing inapplicable. Furthermore, map data is partitioned into tiles with respect to their geographic coordinates. With the limited memory found in portable devices, the number of tiles loaded becomes the major factor for run time. We study routing under these restrictions and present new algorithms as well as empirical evaluations. Our results show that, on average, the most efficient algorithm presented uses more than 20 times fewer tile loads than a normal A*.
Y1  - 2018
SN  - 978-1-5386-6650-0
U6  - https://doi.org/10.1109/SMC.2018.00567
SN  - 1062-922X
SP  - 3347
EP  - 3354
PB  - IEEE
CY  - New York
ER  - 
TY  - GEN
A1  - Kötzing, Timo
A1  - Lagodzinski, Julius Albert Gregor
A1  - Lengler, Johannes
A1  - Melnichenko, Anna
T1  - Destructiveness of Lexicographic Parsimony Pressure and Alleviation by a Concatenation Crossover in Genetic Programming
T2  - Parallel Problem Solving from Nature – PPSN XV
N2  - For theoretical analyses there are two specifics distinguishing GP from many other areas of evolutionary computation. First, the variable size representations, in particular yielding a possible bloat (i.e. the growth of individuals with redundant parts). Second, the role and realization of crossover, which is particularly central in GP due to the tree-based representation. Whereas some theoretical work on GP has studied the effects of bloat, crossover had a surprisingly little share in this work. We analyze a simple crossover operator in combination with local search, where a preference for small solutions minimizes bloat (lexicographic parsimony pressure); the resulting algorithm is denoted Concatenation Crossover GP. For this purpose three variants of the wellstudied Majority test function with large plateaus are considered. We show that the Concatenation Crossover GP can efficiently optimize these test functions, while local search cannot be efficient for all three variants independent of employing bloat control.
Y1  - 2018
SN  - 978-3-319-99259-4
SN  - 978-3-319-99258-7
U6  - https://doi.org/10.1007/978-3-319-99259-4_4
SN  - 0302-9743
SN  - 1611-3349
VL  - 11102
SP  - 42
EP  - 54
PB  - Springer
CY  - Cham
ER  - 
TY  - JOUR
A1  - Schladebach, Marcus
T1  - Grundfragen des Europarechts
JF  - studere : Rechtszeitschrift der Universität Potsdam
Y1  - 2018
SN  - 1867-6170
VL  - 11
IS  - 20
SP  - 18
EP  - 25
PB  - studere e.v.
CY  - Potsdam
ER  -