TY  - GEN
A1  - McKenna, Shane M.
A1  - Leimkühler, Silke
A1  - Herter, Susanne
A1  - Turner, Nicholas J.
A1  - Carnell, Andrew J.
T1  - Enzyme cascade reactions
BT  - synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem
N2  - A one-pot tandem enzyme reaction using galactose oxidase M3–5 and aldehyde oxidase PaoABC was used to convert hydroxymethylfurfural (HMF) to the pure bioplastics precursor FDCA in 74% isolated yield. A range of alcohols was also converted to carboxylic acids in high yield under mild conditions.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 300 
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102271
SP  - 3271
EP  - 3275
ER  - 
TY  - JOUR
A1  - Herter, Susanne
A1  - McKenna, Shane M.
A1  - Frazer, Andrew R.
A1  - Leimkühler, Silke
A1  - Carnell, Andrew J.
A1  - Turner, Nicholas J.
T1  - Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis
JF  - ChemCatChem : heterogeneous & homogeneous & bio- & nano-catalysis ; a journal of ChemPubSoc Europe
N2  - The use of selected engineered galactose oxidase (GOase) variants for the oxidation of amino alcohols to aldehydes under mild conditions in aqueous systems is reported. GOase variant F-2 catalyses the regioselective oxidation of N-carbobenzyloxy (Cbz)-protected 3-amino-1,2-propanediol to the corresponding -hydroxyaldehyde which was then used in an aldolase reaction. Another variant, M3-5, was found to exhibit activity towards free and N-Cbz-protected aliphatic and aromatic amino alcohols allowing the synthesis of lactams such as 3,4-dihydronaphthalen-1(2H)-one, 2-pyrrolidone and valerolactam in one-pot tandem reactions with xanthine dehydrogenase (XDH) or aldehyde oxidase (PaoABC).
KW  - aldehyde oxidase
KW  - amino alcohols
KW  - cascade reactions
KW  - enzyme catalysis
KW  - lactams
Y1  - 2015
U6  - https://doi.org/10.1002/cctc.201500218
SN  - 1867-3880
SN  - 1867-3899
VL  - 7
IS  - 15
SP  - 2313
EP  - 2317
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - McKenna, Shane M.
A1  - Leimkühler, Silke
A1  - Herter, Susanne
A1  - Turner, Nicholas J.
A1  - Carnell, Andrew J.
T1  - Enzyme cascade reactions: synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem
JF  - Green chemistry : an international journal and green chemistry resource
N2  - A one-pot tandem enzyme reaction using galactose oxidase M3-5 and aldehyde oxidase PaoABC was used to convert hydroxymethylfurfural (HMF) to the pure bioplastics precursor FDCA in 74% isolated yield. A range of alcohols was also converted to carboxylic acids in high yield under mild conditions.
Y1  - 2015
U6  - https://doi.org/10.1039/c5gc00707k
SN  - 1463-9262
SN  - 1463-9270
VL  - 17
IS  - 6
SP  - 3271
EP  - 3275
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -