TY - GEN A1 - Esguerra, Alejandro T1 - "A Comment That Might Help Us to Move Along" BT - Brokers in Negotiation Systems T2 - Sustainability Politics and Limited Statehood : Contesting the New Modes of Governance N2 - This chapter investigates the trajectory of establishing the Forest Stewardship Council (FSC) in the early 1990s as the first private transnational certification organization with an antagonistic stakeholder body. Its main contribution is a micro-analysis of the founding assembly in 1993. By investigating the role of brokers within the negotiation as one institutional scope condition for ‘arguing’ having occurred, the chapter adopts a dramaturgical approach. It contends that the authority of brokers is not necessarily institutionally given, but needs to be gained: brokers have to prove situationally that their knowledge is relevant and that they are speaking impartially in the interest of progress rather than their own. The chapter stresses the importance of procedural knowledge which brokers provide in contrast to policy knowledge. Y1 - 2016 SN - 978-3-319-39871-6 SN - 978-3-319-39870-9 U6 - https://doi.org/10.1007/978-3-319-39871-6_2 SP - 25 EP - 46 PB - Cham CY - Basingstoke ER - TY - GEN A1 - Puschmann, Anne-Katrin A1 - Wippert, Pia-Maria T1 - A LONGITUDINAL INTERDISCIPLINARY APPROACH TO STRESS AND ITS IMPACT ON THE DEVELOPMENT OF CHRONIC PAIN T2 - Psychosomatic medicine Y1 - 2016 SN - 0033-3174 SN - 1534-7796 VL - 78 SP - A91 EP - A91 PB - Routledge, Taylor & Francis Group CY - Philadelphia ER - TY - GEN A1 - Levermann, Anders A1 - Petoukhov, Vladimir A1 - Schewe, Jacob A1 - Schellnhuber, Hans Joachim T1 - Abrupt monsoon transitions as seen in paleorecords can be explained by moisture-advection feedback T2 - Proceedings of the National Academy of Sciences of the United States of America Y1 - 2016 U6 - https://doi.org/10.1073/pnas.1603130113 SN - 0027-8424 VL - 113 SP - E2348 EP - E2349 PB - National Acad. of Sciences CY - Washington ER - TY - GEN A1 - Bürger, Andreas A1 - Magdans, Uta A1 - Gies, Hermann T1 - Adsorption of amino acids on the magnetite-(111)-surface: a force field study (vol 19, 851, 2013) T2 - Journal of molecular modeling Y1 - 2016 U6 - https://doi.org/10.1007/s00894-016-3124-8 SN - 1610-2940 SN - 0948-5023 VL - 22 PB - Springer CY - New York ER - TY - GEN A1 - Ehmer, Oliver A1 - Barth-Weingarten, Dagmar T1 - Adverbial patterns in interaction T2 - Language sciences Y1 - 2016 U6 - https://doi.org/10.1016/j.langsci.2016.05.001 SN - 0388-0001 SN - 1873-5746 VL - 58 SP - 1 EP - 7 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Heinz, Andreas A1 - Beck, Anne A1 - Rapp, Michael Armin T1 - Alcohol as an Environmental Mortality Hazard T2 - JAMA psychiatry Y1 - 2016 U6 - https://doi.org/10.1001/jamapsychiatry.2016.0399 SN - 2168-622X SN - 2168-6238 VL - 73 SP - 549 EP - 550 PB - American Veterinary Medical Association CY - Chicago ER - TY - GEN A1 - Grüne, Stefanie T1 - Allais on Intuitions and the Objective Reality of the Categories T2 - European journal of philosophy Y1 - 2016 U6 - https://doi.org/10.1111/ejop.12139 SN - 0966-8373 SN - 1468-0378 VL - 24 SP - 241 EP - 252 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Passarelli, Luigi A1 - Hainzl, Sebastian A1 - Cesca, Simone A1 - Maccaferri, Francesco A1 - Mucciarelli, Marco A1 - Roessler, Dirk A1 - Corbi, Fabio A1 - Dahm, Torsten A1 - Rivalta, Eleonora T1 - Aseismic transient driving the swarm-like seismic sequence in the Pollino range, Southern Italy (vol 201, pg 1553, 2015) T2 - Geophysical journal international KW - Seismicity and tectonics KW - Statistical seismology KW - Dynamics: seismotectonics Y1 - 2016 U6 - https://doi.org/10.1093/gji/ggv425 SN - 0956-540X SN - 1365-246X VL - 204 SP - 365 EP - 365 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Wippert, Pia-Maria A1 - Puschmann, Anne-Katrin A1 - Schiltenwolf, Marcus A1 - Wiebking, Christine A1 - Mayer, Frank T1 - BACK PAIN: THE STUDY OF MECHANISMS AND THE TRANSLATION IN INTERVENTIONS WITHIN THE MISPEX NETWORK T2 - Psychosomatic medicine Y1 - 2016 SN - 0033-3174 SN - 1534-7796 VL - 78 SP - A91 EP - A91 PB - Elsevier CY - Philadelphia ER - TY - GEN A1 - Mondal, Suvendu Sekhar A1 - Holdt, Hans-Jürgen T1 - Breaking Down Chemical Weapons by Metal-Organic Frameworks T2 - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition N2 - Seek and destroy: Filtration schemes and self-detoxifying protective fabrics based on the ZrIV-containing metal—organic frameworks (MOFs) MOF-808 and UiO-66 doped with LiOtBu have been developed that capture and hydrolytically detoxify simulants of nerve agents and mustard gas. Both MOFs function as highly catalytic elements in these applications. KW - heterogeneous catalysis KW - hydrolysis KW - metalorganic frameworks KW - nerve agents KW - silk fibroin Y1 - 2016 U6 - https://doi.org/10.1002/anie.201508407 SN - 1433-7851 SN - 1521-3773 VL - 55 SP - 42 EP - 44 PB - Wiley-VCH CY - Weinheim ER - TY - GEN A1 - Hanack, Katja A1 - Schloer, Anja A1 - Holzloehner, Pamela A1 - Listek, Martin A1 - Bauer, Cindy A1 - Butze, Monique A1 - Micheel, Burkhard A1 - Hentschel, Christian A1 - Sowa, Mandy A1 - Roggenbuck, Dirk A1 - Schierack, Peter A1 - Fuener, Jonas A1 - Schliebs, Erik A1 - Goihl, Alexander A1 - Reinhold, Dirk T1 - Camelid nanobodies specific to human pancreatic glycoprotein 2 T2 - The journal of immunology N2 - Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified to be a major autoantigenic target in Crohn’s disease patients. It was discussed recently that a long and a short isoform of GP2 exists whereas the short isoform is often detected by GP2-specific autoantibodies. In the outcome of inflammatory bowel diseases, these GP2-specific autoantibodies are discussed as new serological markers for diagnosis and therapeutic monitoring. To investigate this further, camelid nanobodies were generated by phage display and selected against the short isoform of GP2 in order to isolate specific tools for the discrimination of both isoforms. Nanobodies are single domain antibodies derived from camelid heavy chain only antibodies and characterized by a high stability and solubility. The selected candidates were expressed, purified and validated regarding their binding properties in different enzyme-linked immunosorbent assays formats, immunofluorescence, immunohistochemistry and surface plasmon resonance spectroscopy. Four different nanobodies could be selected whereof three recognize the short isoform of GP2 very specifically and one nanobody showed a high binding capacity for both isoforms. The KD values measured for all nanobodies were between 1.3 nM and 2.3 pM indicating highly specific binders suitable for the application as diagnostic tool in inflammatory bowel disease. Y1 - 2016 SN - 0022-1767 SN - 1550-6606 VL - 196 SP - 313 EP - 328 PB - American Assoc. of Immunologists CY - Bethesda ER - TY - GEN A1 - Maier, Natalia A1 - Holzlöhner, Pamela A1 - Hoenow, Anja A1 - Scheunemann, Astrid A1 - Weschke, Daniel A1 - Hanack, Katja T1 - Characterization of monoclonal antibodies generated by in vitro immunization T2 - The journal of immunology N2 - Monoclonal antibodies are highly valuable tools in biomedicine but the generation by hybridoma technology is very time-consuming and elaborate. In order to circumvent the consisting drawbacks an in vitro immunization approach was established by which murine as well as human monoclonal antibodies against a viral coat protein could be developed. The in vitro immunization process was performed by isolation of murine hematopoietic stem cells or human monocytes and an in vitro differentiation into immature dendritic cells. After antigen loading the cells were co-cultivated with naive T and B lymphocytes for three days in order to obtain antigen-specific B lymphocytes in culture, followed by fusion with murine myeloma cells or human/murine heteromyeloma cells. Antigen-specific hybridomas were selected and the generated antibodies were purified and characterized in this study by ELISA, western blot, gene sequencing, affinity measurements. Further the characteristics were compared to a monoclonal antibody against the same target generated by conventional hybridoma technology. Isotype detection revealed a murine IgM and a human IgG4 antibody in comparison to an IgG1 for the conventionally generated antibody. The antibodies derived from in vitro immunization showed indeed a lower affinity for the antigen as compared to the conventionally generated one, which is probably based on the significantly shorter B cell maturation (3 days) during the immunization process. Nevertheless, they were suitable for building up a sandwich based detection system. Therefore, the in vitro immunization approach seems to be a good and particularly fast alternative to conventional hybridoma technology. Y1 - 2016 SN - 0022-1767 SN - 1550-6606 VL - 196 PB - American Assoc. of Immunologists CY - Bethesda ER - TY - GEN A1 - Nojima, Hiroyuki A1 - Konishi, Takanori A1 - Japtok, Lukasz A1 - Kleuser, Burkhard A1 - Edwards, Michael J. A1 - Gulbins, Erich A1 - Lentsch, Alex B. T1 - Chemokine receptors, CXCR1 and CXCR2, differentially regulate exosome release in hepatocytes T2 - Hepatology : official journal of the American Association for the Study of Liver Diseases Y1 - 2016 SN - 0270-9139 SN - 1527-3350 VL - 64 SP - 165A EP - 165A PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Teif, Vladimir B. A1 - Cherstvy, Andrey G. T1 - Chromatin and epigenetics: current biophysical views T2 - AIMS biophysics N2 - Recent advances in high-throughput sequencing experiments and their theoretical descriptions have determined fast dynamics of the "chromatin and epigenetics" field, with new concepts appearing at high rate. This field includes but is not limited to the study of DNA-protein-RNA interactions, chromatin packing properties at different scales, regulation of gene expression and protein trafficking in the cell nucleus, binding site search in the crowded chromatin environment and modulation of physical interactions by covalent chemical modifications of the binding partners. The current special issue does not pretend for the full coverage of the field, but it rather aims to capture its development and provide a snapshot of the most recent concepts and approaches. Eighteen open-access articles comprising this issue provide a delicate balance between current theoretical and experimental biophysical approaches to uncover chromatin structure and understand epigenetic regulation, allowing free flow of new ideas and preliminary results. KW - chromatin KW - epigenetics KW - linker histones KW - nucleosome KW - DNA-protein binding KW - histone modifications KW - remodelers KW - topologically associated domains KW - DNA methylation KW - DNA supercoiling Y1 - 2016 U6 - https://doi.org/10.3934/biophy.2016.1.88 SN - 2377-9098 VL - 3 SP - 88 EP - 98 PB - American Institute of Mathematical Sciences CY - Springfield ER - TY - GEN A1 - Alsemgeest, Jitse A1 - Schröder, S. A1 - Boettger, Ute A1 - Pavlov, S. G. A1 - Weber, I. A1 - Greshake, A. A1 - Knöfler, H. -R. A1 - Altenberger, Uwe A1 - Hübers, H. -W. T1 - COMBINED RAMAN-LIBS STUDIES ON IRON SULFIDES TO INVESTIGATE THE EFECTS OF THE LIBS PLASMA ON THE MINERAL COMPOSITION. T2 - Monthly notices of the Royal Astronomical Society Y1 - 2016 SN - 1086-9379 SN - 1945-5100 VL - 51 SP - A147 EP - A147 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Berenstein, Igal A1 - Beta, Carsten A1 - De Decker, Yannick T1 - Comment on "Flow-induced arrest of spatiotemporal chaos and transition to a stationary pattern in the Gray-Scott model" T2 - Physical review : E, Statistical, nonlinear and soft matter physics N2 - In this Comment, we review the results of pattern formation in a reaction-diffusion-advection system following the kinetics of the Gray-Scott model. A recent paper by Das [Phys. Rev. E 92, 052914 (2015)] shows that spatiotemporal chaos of the intermittency type can disappear as the advective flow is increased. This study, however, refers to a single point in the space of kinetic parameters of the original Gray-Scott model. Here we show that the wealth of patterns increases substantially as some of these parameters are changed. In addition to spatiotemporal intermittency, defect-mediated turbulence can also be found. In all cases, however, the chaotic behavior is seen to disappear as the advective flow is increased, following a scenario similar to what was reported in our earlier work [I. Berenstein and C. Beta, Phys. Rev. E 86, 056205 (2012)] as well as by Das. We also point out that a similar phenomenon can be found in other reaction-diffusion-advection models, such as the Oregonator model for the Belousov-Zhabotinsky reaction under flow conditions. Y1 - 2016 U6 - https://doi.org/10.1103/PhysRevE.94.046201 SN - 2470-0045 SN - 2470-0053 VL - 94 PB - American Physical Society CY - College Park ER - TY - GEN A1 - Demmerling, Christoph A1 - Krüger, Hans-Peter A1 - Habermas, Jürgen T1 - Communicative Reason Juergen Habermas, interviewed by Christoph Demmerling and Hans-Peter Krueger T2 - Deutsche Zeitschrift für Philosophie : Zweimonatsschrift der internationalen philosophischen Forschung N2 - Jurgen Habermas explicates the concept of communicative reason. He explains the key assumptions of the philosophy of language and social theory associated with this concept. Also discussed is the category of life-world and the role of the body-mind difference for the consciousness of exclusivity in our access to subjective experience. as well as the role of emotions and perceptions in the context of a theory of communicative action. The question of the redemption of the various validity claims as they are associated with the performance of speech acts is related to processes of social learning and to the role of negative experiences. Finally the interview deals with the relationship between religion and reason and the importance of religion in modern, post-secular societies. Questions about the philosophical culture of our present times are discussed at the end of the conversation. KW - Jurgen Habermas KW - communicative action KW - communicative reason KW - critical theory KW - life-world KW - religion KW - post-secular society Y1 - 2016 U6 - https://doi.org/10.1515/dzph-2016-0061 SN - 0012-1045 SN - 2192-1482 VL - 64 SP - 806 EP - 827 PB - De Gruyter CY - Berlin ER - TY - GEN A1 - Battiston, Stefano A1 - Farmer, J. Doyne A1 - Flache, Andreas A1 - Garlaschelli, Diego A1 - Haldane, Andrew G. A1 - Heesterbeek, Hans A1 - Hommes, Cars A1 - Jaeger, Carlo A1 - May, Robert A1 - Scheffer, Marten T1 - COMPLEX SYSTEMS Complexity theory and financial regulation T2 - Science N2 - Traditional economic theory could not explain, much less predict, the near collapse of the financial system and its long-lasting effects on the global economy. Since the 2008 crisis, there has been increasing interest in using ideas from complexity theory to make sense of economic and financial markets. Concepts, such as tipping points, networks, contagion, feedback, and resilience have entered the financial and regulatory lexicon, but actual use of complexity models and results remains at an early stage. Recent insights and techniques offer potential for better monitoring and management of highly interconnected economic and financial systems and, thus, may help anticipate and manage future crises. Y1 - 2016 U6 - https://doi.org/10.1126/science.aad0299 SN - 0036-8075 SN - 1095-9203 VL - 351 SP - 818 EP - 819 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - GEN A1 - Esguerra, Alejandro ED - Esguerra, Alejandro ED - Helmerich, Nicole ED - Risse, Thomas T1 - Conclusion T2 - Sustainability Politics and Limited Statehood: Contesting the New Modes of Governance N2 - This chapter revisits the role of the new modes of governance in areas of limited statehood. First, it states that there is no linear relationship between degrees of statehood and the overall effectiveness of new modes of sustainability governance. Second, the chapter states that, in most of the cases, national governments are hesitant or even actively hamper the development of new modes of governance. Third, it shows that the absence of the shadow of hierarchy can indeed lead to ineffective new modes of governance. However, the shadow of hierarchy does not necessarily need to be cast by states. Finally, the author reviews the complexities involved in participatory practices, stressing the importance of institutional structures and knowledgeable brokers. The chapter concludes by outlining fields for future research. Y1 - 2016 SN - 978-3-319-39871-6 SN - 978-3-319-39870-9 U6 - https://doi.org/10.1007/978-3-319-39871-6_9 SP - 211 EP - 224 PB - Cham CY - Basingstoke ER - TY - GEN A1 - Bijleveld, Catrien A1 - Zoutewelle-Terovan, Mioara A1 - Huschek, Doreen A1 - Liefbroer, Aart C. T1 - Criminal careers and demographic outcomes: An introduction to the special issue T2 - Advances in life course research Y1 - 2016 U6 - https://doi.org/10.1016/j.alcr.2016.05.001 SN - 1569-4909 SN - 1879-6974 VL - 28 SP - 1 EP - 5 PB - Elsevier CY - Oxford ER -