TY  - JOUR
A1  - Tschorn, Mira
A1  - Kuhlmann, Stella Linnea
A1  - Rieckmann, Nina
A1  - Beer, Katja
A1  - Grosse, Laura
A1  - Arolt, Volker
A1  - Waltenberger, Johannes
A1  - Haverkamp, Wilhelm
A1  - Müller-Nordhorn, Jacqueline
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
T1  - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease
JF  - Acta Neuropsychiatrica
N2  - Objective: 
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). 

Methods: 
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. 

Results: 
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. 

Conclusion: 
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
KW  - depression
KW  - BDNF
KW  - coronary heart disease
KW  - heart failure
KW  - somatic comorbidity
KW  - acute coronary syndrome
Y1  - 2020
U6  - https://doi.org/10.1017/neu.2020.31
SN  - 1601-5215
SN  - 0924-2708
VL  - 33
IS  - 1
SP  - 22
EP  - 30
PB  - Cambridge Univ. Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Reibis, Rona Katharina
A1  - Salzwedel, Annett
A1  - Abreu, Ana
A1  - Corra, Ugo
A1  - Davos, Constantinos
A1  - Döhner, Wolfram
A1  - Doherty, Patrick
A1  - Frederix, Ines
A1  - Hansen, Dominique
A1  - Iliou, Marie Christine
A1  - Vigorito, Carlo
A1  - Völler, Heinz
T1  - The importance of return to work
BT  - How to achieve optimal reintegration in ACS patients
JF  - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology
N2  - The vocational reintegration of patients after an acute coronary syndrome is a crucial step towards complete convalescence from the social as well as the individual point of view. Return to work rates are determined by medical parameters such as left ventricular function, residual ischaemia and heart rhythm stability, as well as by occupational requirement profile such as blue or white collar work, night shifts and the ability to commute (which is, in part, determined by physical fitness). Psychosocial factors including depression, self-perceived health situation and pre-existing cognitive impairment determine the reintegration rate to a significant extent. Patients at risk of poor vocational outcomes should be identified in the early period of rehabilitation to avoid a reintegration failure and to prevent socio-professional exclusion with adverse psychological and financial consequences. A comprehensive healthcare pathway of acute coronary syndrome patients is initiated by cardiac rehabilitation, which includes specific algorithms and assessment tools for risk stratification and occupational restitution. As the first in its kind, this review addresses determinants and legal aspects of reintegration of patients experiencing an acute coronary syndrome, and offers practical advice on reintegration strategies particularly for vulnerable patients. It presents different approaches and scientific findings in the European countries and serves as a recommendation for action.
KW  - Return to work
KW  - acute coronary syndrome
KW  - predictors
KW  - pension insurance
Y1  - 2019
U6  - https://doi.org/10.1177/2047487319839263
SN  - 2047-4873
SN  - 2047-4881
VL  - 26
IS  - 13
SP  - 1358
EP  - 1369
PB  - Sage Publ.
CY  - London
ER  -