TY  - JOUR
A1  - Schlickewei, Ole
A1  - Nienstedt, Julie Cläre
A1  - Frank, Ulrike
A1  - Fründt, Odette
A1  - Pötter-Nerger, Monika
A1  - Gerloff, Christian
A1  - Buhmann, Carsten
A1  - Müller, Frank
A1  - Lezius, Susanne
A1  - Koseki, Jana-Christiane
A1  - Pflug, Christina
T1  - The ability of the eating assessment tool‑10 to detect penetration and aspiration in Parkinson’s disease
JF  - European archives of oto-rhino-laryngology and head & neck
N2  - Purpose:
Dysphagia is common in patients with Parkinson's disease (PD) and often leads to pneumonia, malnutrition, and reduced quality of life. This study investigates the ability of the Eating Assessment Tool-10 (EAT-10), an established, easy self-administered screening tool, to detect aspiration in PD patients. This study aims to validate the ability of the EAT-10 to detect FEES-proven aspiration in patients with PD.

Methods:
In a controlled prospective cross-sectional study, a total of 50 PD patients completed the EAT-10 and, subsequently, were examined by Flexible Endoscopic Evaluation of Swallowing (FEES) to determine the swallowing status. The results were rated through the Penetration-Aspiration Scale (PAS) and data were analyzed retrospectively. 

Results:
PAS and EAT-10 did not correlate significantly. Selected items of the EAT-10 could not predict aspiration or residues. 19 (38%) out of 50 patients with either penetration or aspiration were not detected by the EAT-10. The diagnostic accuracy was established at only a sufficient level (AUC 0.65). An optimal cut-off value of >= 6 presented a sensitivity of 58% and specificity of 82%.

Conclusions:
The EAT-10 is not suited for the detection of penetration and aspiration in PD patients. Therefore, it cannot be used as a screening method in this patient population. There is still a need for a valid, simple, and efficient screening tool to assist physicians in their daily diagnostics and to avoid clinical complications.
KW  - Parkinson's disease
KW  - dysphagia
KW  - questionnaire
KW  - screening
Y1  - 2020
U6  - https://doi.org/10.1007/s00405-020-06377-x
SN  - 0937-4477
SN  - 1434-4726
VL  - 278
IS  - 5
SP  - 1661
EP  - 1668
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Hortobagyi, Tibor
A1  - Granacher, Urs
A1  - Fernandez-del-Olmo, Miguel
A1  - Howatson, Glyn
A1  - Manca, Andrea
A1  - Deriu, Franca
A1  - Taube, Wolfgang
A1  - Gruber, Markus
A1  - Marquez, Gonzalo
A1  - Lundbye-Jensen, Jesper
A1  - Colomer-Poveda, David
T1  - Functional relevance of resistance training-induced neuroplasticity in health and disease
JF  - Neuroscience & biobehavioral reviews : official journal of the International Behavioral Neuroscience Society
N2  - Repetitive, monotonic, and effortful voluntary muscle contractions performed for just a few weeks, i.e., resistance training, can substantially increase maximal voluntary force in the practiced task and can also increase gross motor performance. The increase in motor performance is often accompanied by neuroplastic adaptations in the central nervous system. While historical data assigned functional relevance to such adaptations induced by resistance training, this claim has not yet been systematically and critically examined in the context of motor performance across the lifespan in health and disease. A review of muscle activation, brain and peripheral nerve stimulation, and imaging data revealed that increases in motor performance and neuroplasticity tend to be uncoupled, making a mechanistic link between neuroplasticity and motor performance inconclusive. We recommend new approaches, including causal mediation analytical and hypothesis-driven models to substantiate the functional relevance of resistance training-induced neuroplasticity in the improvements of gross motor function across the lifespan in health and disease.
KW  - Maximal voluntary contraction (MVC)
KW  - strength training
KW  - Electromyography (EMG)
KW  - Transcranial magnetic brain stimulation (TMS)
KW  - Electroencephalography (EEG)
KW  - Functional magnetic resonance imaging (fMRI)
KW  - athletic performance
KW  - aging
KW  - Parkinson's disease
KW  - Multiple sclerosis
KW  - stroke
KW  - directed acyclic graphs
KW  - causal mediation analysis
Y1  - 2020
U6  - https://doi.org/10.1016/j.neubiorev.2020.12.019
SN  - 0149-7634
SN  - 1873-7528
VL  - 122
SP  - 79
EP  - 91
PB  - Elsevier
CY  - Oxford
ER  -