TY - JOUR A1 - Kilercik, Meltem A1 - Ucal, Yasemin A1 - Serdar, Muhittin A1 - Serteser, Mustafa A1 - Ozpinar, Aysel A1 - Schweigert, Florian J. T1 - Zinc protoporphyrin levels in COVID-19 are indicative of iron deficiency and potential predictor of disease severity JF - PLoS ONE N2 - Background Coronavirus disease (COVID-19) has a severe impact on all aspects of patient care. Among the numerous biomarkers of potential validity for diagnostic and clinical management of COVID-19 are biomarkers at the interface of iron metabolism and inflammation. Methods The follow-up study included 54 hospitalized patients with laboratory-confirmed COVID-19 with a moderate and severe/critical form of the disease. Iron deficiency specific biomarkers such as iron, ferritin, transferrin receptor, hepcidin, and zinc protoporphyrin (ZnPP) as well as relevant markers of inflammation were evaluated twice: in the first five days when the patient was admitted to the hospital and during five to 15 days; and their validity to diagnose iron deficiency was further assessed. The regression and Receiver Operating Characteristics (ROC) analyses were performed to evaluate the prognosis and determine the probability for predicting the severity of the disease in the first five days of COVID-19. Results Based on hemoglobin values, anemia was observed in 21 of 54 patients. Of all iron deficiency anemia-related markers, only ZnPP was significantly elevated (P<0.001) in the anemic group. When patients were grouped according to the severity of disease, slight differences in hemoglobin or other anemia-related parameters could be observed. However, the levels of ZnPP were significantly increased in the severely ill group of patients. The ratio of ZnPP to lymphocyte count (ZnPP/L) had a discrimination power stronger than the neutrophil to lymphocyte count ratio (N/L) to determine disease severity. Additionally, only two markers were independently associated with the severity of COVID-19 in logistic regression analysis; D-dimer (OR (5.606)(95% CI 1.019–30.867)) and ZnPP/L ratio (OR (74.313) (95% CI 1.081–5108.103)). Conclusions For the first time ZnPP in COVID-19 patients were reported in this study. Among all iron-related markers tested, ZnPP was the only one that was associated with anemia as based on hemoglobin. The increase in ZnPP might indicate that the underlying cause of anemia in COVID-19 patients is not only due to the inflammation but also of nutritional origin. Additionally, the ZnPP/L ratio might be a valid prognostic marker for the severity of COVID-19. KW - COVID 19 KW - Hemoglobin KW - Ferritin KW - Lymphocytes KW - Anemia KW - Reticulocytes KW - Iron deficiency anemia KW - Neutrophils Y1 - 2021 U6 - https://doi.org/10.1371/journal.pone.0262487 SN - 1932-6203 VL - 17 IS - 2 PB - PLOS CY - San Francisco, California, US ER - TY - JOUR A1 - Hoffmann, Julia A1 - Hölker, Franz A1 - Eccard, Jana T1 - Welcome to the Dark Side BT - Partial Nighttime Illumination Affects Night-and Daytime Foraging Behavior of a Small Mammal JF - Frontiers in Ecology and Evolution N2 - Differences in natural light conditions caused by changes in moonlight are known to affect perceived predation risk in many nocturnal prey species. As artificial light at night (ALAN) is steadily increasing in space and intensity, it has the potential to change movement and foraging behavior of many species as it might increase perceived predation risk and mask natural light cycles. We investigated if partial nighttime illumination leads to changes in foraging behavior during the night and the subsequent day in a small mammal and whether these changes are related to animal personalities. We subjected bank voles to partial nighttime illumination in a foraging landscape under laboratory conditions and in large grassland enclosures under near natural conditions. We measured giving-up density of food in illuminated and dark artificial seed patches and video recorded the movement of animals. While animals reduced number of visits to illuminated seed patches at night, they increased visits to these patches at the following day compared to dark seed patches. Overall, bold individuals had lower giving-up densities than shy individuals but this difference increased at day in formerly illuminated seed patches. Small mammals thus showed carry-over effects on daytime foraging behavior due to ALAN, i.e., nocturnal illumination has the potential to affect intra- and interspecific interactions during both night and day with possible changes in personality structure within populations and altered predator-prey dynamics. KW - light pollution KW - inter-individual differences KW - animal personality KW - Myodes glareolus KW - ALAN Y1 - 2021 U6 - https://doi.org/10.3389/fevo.2021.779825 SN - 2296-701X VL - 9 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Francke, Till A1 - Heistermann, Maik A1 - Köhli, Markus A1 - Budach, Christian A1 - Schrön, Martin A1 - Oswald, Sascha T1 - Assessing the feasibility of a directional cosmic-ray neutron sensing sensor for estimating soil moisture JF - Geoscientific Instrumentation, Methods and Data Systems N2 - Cosmic-ray neutron sensing (CRNS) is a non-invasive tool for measuring hydrogen pools such as soil moisture, snow or vegetation. The intrinsic integration over a radial hectare-scale footprint is a clear advantage for averaging out small-scale heterogeneity, but on the other hand the data may become hard to interpret in complex terrain with patchy land use. This study presents a directional shielding approach to prevent neutrons from certain angles from being counted while counting neutrons entering the detector from other angles and explores its potential to gain a sharper horizontal view on the surrounding soil moisture distribution. Using the Monte Carlo code URANOS (Ultra Rapid Neutron-Only Simulation), we modelled the effect of additional polyethylene shields on the horizontal field of view and assessed its impact on the epithermal count rate, propagated uncertainties and aggregation time. The results demonstrate that directional CRNS measurements are strongly dominated by isotropic neutron transport, which dilutes the signal of the targeted direction especially from the far field. For typical count rates of customary CRNS stations, directional shielding of half-spaces could not lead to acceptable precision at a daily time resolution. However, the mere statistical distinction of two rates should be feasible. KW - water-balance KW - quantification KW - calibration KW - validation Y1 - 2021 U6 - https://doi.org/10.5194/gi-11-75-2022 SN - 2193-0864 SN - 2193-0856 VL - 11 SP - 75 EP - 92 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Heinze, Peter Eric A1 - Weck, Florian A1 - Kühne, Franziska T1 - Assessing Patient Preferences BT - Examination of the German Cooper-Norcross Inventory of Preferences JF - Frontiers in Psychology N2 - Despite the positive effects of including patients’ preferences into therapy on psychotherapy outcomes, there are still few thoroughly validated assessment tools at hand. We translated the 18-item Cooper-Norcross Inventory of Preferences (C-NIP) into German and aimed at replicating its factor structure. Further, we investigated the reliability of the questionnaire and its convergence with trait measures. A heterogeneous sample of N = 969 participants took part in our online survey. Performing ESEM models, we found acceptable model fit for a four-factor structure similar to the original factor structure. Furthermore, we propose an alternative model following the adjustment of single items. The German C-NIP showed acceptable to good reliability, as well as small correlations with Big-Five personality traits, trait and attachment anxiety, locus of control, and temporal focus. However, we recommend further replication of the factor structure and further validation of the C-NIP. KW - psychotherapy KW - preference KW - activity preference KW - preference assessment KW - validation study Y1 - 2021 U6 - https://doi.org/10.3389/fpsyg.2021.795776 SN - 1664-1078 VL - 12 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Loges, Klara A1 - Tiberius, Victor T1 - Implementation Challenges of 3D Printing in Prosthodontics BT - A Ranking-Type Delphi JF - Materials N2 - The reduction in cost and increasing benefits of 3D printing technologies suggest the potential for printing dental prosthetics. However, although 3D printing technologies seem to be promising, their implementation in practice is complicated. To identify and rank the greatest implementation challenges of 3D printing in dental practices, the present study surveys dentists, dental technicians, and 3D printing companies using a ranking-type Delphi study. Our findings imply that a lack of knowledge is the most crucial obstacle to the implementation of 3D printing technologies. The high training effort of staff and the favoring of conventional methods, such as milling, are ranked as the second and third most relevant factors. Investment costs ranked in seventh place, whereas the lack of manufacturing facilities and the obstacle of print duration ranked below average. An inclusive implementation of additive manufacturing could be achieved primarily through the education of dentists and other staff in dental practices. In this manner, production may be managed internally, and the implementation speed may be increased. KW - 3D printing KW - prosthodontics KW - ranking type Delphi study KW - additive manufacturing KW - dentistry Y1 - 2021 U6 - https://doi.org/10.3390/ma15020431 SN - 1996-1944 VL - 15 PB - MDPI CY - Basel ER - TY - JOUR A1 - Rieck, Christian E. T1 - Strange New Worlds BT - the European Union's Search for Like-Minded Partners in the Indo-Pacific JF - European Strategic Approaches to the Indo-Pacific N2 - The Indo-Pacific is fast becoming the main arena for great power competition. After explaining the regional power hierarchy, the paper describes how the EU defines like-mindedness as an explicit partnership category in the Indo-Pacific and which of the countries qualify. Finally, the paper also examines the structural problems the EU faces when projecting power into a faraway region such as this one. The paper argues that for China’s rise to remain peaceful and in the absence of fully regional security arrangements, other Asian actors are increasingly looking for new regional structures that combine elements of cooperation, competition and containment vis-à-vis China - including a more pronounced EU role in the region. Y1 - 2022 UR - https://www.kas.de/en/web/politikdialog-asien/panorama SN - 0119-5204 VL - 2021 IS - 1 SP - 39 EP - 53 PB - Konrad-Adenauer-Stiftung CY - Singapore ER - TY - JOUR A1 - Kosman, Admiʾel A1 - Hadad, Yemima T1 - The societal role of the man of spirit according to Martin Buber JF - Hebrew Union College annual / Jewish Institute of Religion : HUCA N2 - This study offers a view into Buber's conception of the social role of the “person of spirit” – the individual who, in other contexts, would be called philosopher, thinker, or intellectual.A key element of the person of spirit's role, according to Buber, is the evaluation of social reality – judging the public's ability to be guided by the realm of the spirit at any given hour while responding to the challenges that this particular hour may present. The person of spirit is required to constantly mediate between “heaven” and “earth” – between the ideal and reality – even if in a particular situation the moral action which has to be taken can only be partial, and will fall short of the absolute demand of the spirit.Buber emphasizes that the influence of the spirit on reality always begins with an effort of the “person of spirit” to transform him or herself from a monological to a dialogical person. Without a dialogical affinity between the person of spirit and their community, there can be no real effect of the spirit on reality.The person of spirit is, therefore, according to Buber, fully involved in the social life of the community. Our study shows that Buber shaped this figure of the “person of spirit” by combining the model of the biblical prophet, who is sent to the people, with the model of the Hasidic leader who acts according to the principle of the “Descent of the Zaddik.” The person of spirit is required to live their life in a “Thou” relationship with their community, and is therefore frequently descending from an elevated spiritual level to the level of the people, in order to empathetically share their mundane worries, fears, and afflictions.By comparing the models of the biblical prophet and the Hassidic Zaddik to the model of the Greek prophetes and Plato's philosopher-king, we can, according to Buber, reflect on the role of the person of spirit in society in our time as well. KW - Buber, Martin KW - Jewish philosophy 20th century KW - Zaddikim History of doctrines Y1 - 2022 U6 - https://doi.org/10.15650/hebruniocollannu.91.2020.0207 SN - 0360-9049 VL - 91 SP - 207 EP - 259 PB - College CY - Cincinnati ER - TY - JOUR A1 - Riederer, Bernhard Edwin A1 - Verwiebe, Roland A1 - Ahn, Byeongsun T1 - Professionalisation, polarisation or both? BT - economic restructuring and new divisions of labour JF - Vienna Y1 - 2022 SN - 978-0-367-68011-4 SN - 978-1-003-13382-7 SN - 978-0-367-68013-8 U6 - https://doi.org/10.4324/9781003133827-10 SP - 99 EP - 114 PB - Routledge CY - Berlin ER - TY - JOUR A1 - Kazepov, Yuri A1 - Verwiebe, Roland T1 - Is Vienna still a just city? BT - the challenges of transitions JF - Vienna Y1 - 2022 SN - 978-0-367-68011-4 SN - 978-1-003-13382-7 SN - 978-0-367-68013-8 U6 - https://doi.org/10.4324/9781003133827-1 SP - 1 EP - 14 PB - Routledge CY - London ER - TY - JOUR A1 - Burkert, Rebecca T1 - Moving mountains? BT - Palestinian clain making from JF - The condition of democracy. - Volume 3 : Postcolonial and settler colonial contexts Y1 - 2022 SN - 978-0-367-74538-7 SN - 978-1-003-15838-7 SP - 110 EP - 127 PB - Routledge CY - London ER - TY - JOUR A1 - Hartmann, Eddy A1 - Lang, Felix T1 - The crisis of social trust in non-violent routines BT - social mobilization of right-wing violence in Germany JF - The condition of democracy. - Volume 2: Contesting citizenship Y1 - 2022 SN - 978-0-367-74536-3 SN - 978-1-00-315837-0 SP - 104 PB - Routledge CY - London ER - TY - JOUR A1 - Schmidt, Max Oliver T1 - Church asylum as ultima ratio BT - fighting for access to German society JF - The condition of democracy. - Volume 2: Contesting citizenship Y1 - 2022 SN - 978-0-367-74536-3 SN - 978-1-00-315837-0 SP - 36 EP - 53 PB - Routledge CY - London ER - TY - JOUR A1 - Forlenza, Rosario A1 - Turner, Bryan S. T1 - Roman Catholicism and democracy BT - international conservatism and external liberalis? JF - The condition of democracy : Volume 1: Neoliberal politics and sociological perspectives Y1 - 2022 SN - 978-1-00-040191-2 SN - 978-1-00-315836-3 SP - 149 EP - 164 PB - Routledge CY - London ER - TY - JOUR A1 - Schmidt-Wellenburg, Christian T1 - Democratization or politicization? BT - The changing face of political-economic expertide in European expert groups, 1966-2017 JF - The condition of democracy : Volume 1: Neoliberal politics and sociological perspectives Y1 - 2022 SN - 978-1-00-040191-2 SN - 978-1-00-315836-3 SP - 106 EP - 128 PB - Routledge CY - London ER - TY - JOUR A1 - Turner, Bryan S. T1 - Introduction BT - waves of democracy JF - The condition of democracy : Volume 1: Neoliberal politics and sociological perspectives Y1 - 2022 SN - 978-1-00-040191-2 SN - 978-1-00-315836-3 SP - 1 EP - 15 PB - Routledge CY - London ER -