TY  - JOUR
A1  - Sieg, Tobias
A1  - Vogel, Kristin
A1  - Merz, Bruno
A1  - Kreibich, Heidi
T1  - Seamless Estimation of Hydrometeorological Risk Across Spatial Scales
JF  - Earth's Future
N2  - Hydrometeorological hazards caused losses of approximately 110 billion U.S. Dollars in 2016 worldwide. Current damage estimations do not consider the uncertainties in a comprehensive way, and they are not consistent between spatial scales. Aggregated land use data are used at larger spatial scales, although detailed exposure data at the object level, such as openstreetmap.org, is becoming increasingly available across the globe.We present a probabilistic approach for object-based damage estimation which represents uncertainties and is fully scalable in space. The approach is applied and validated to company damage from the flood of 2013 in Germany. Damage estimates are more accurate compared to damage models using land use data, and the estimation works reliably at all spatial scales. Therefore, it can as well be used for pre-event analysis and risk assessments. This method takes hydrometeorological damage estimation and risk assessments to the next level, making damage estimates and their uncertainties fully scalable in space, from object to country level, and enabling the exploitation of new exposure data.
KW  - spatial scales
KW  - risk assessment
KW  - hydro-meterological hazards
KW  - object-based damage modeling
KW  - uncertainty
KW  - probabilistic approaches
Y1  - 2019
U6  - https://doi.org/10.1029/2018EF001122
SN  - 2328-4277
VL  - 7
IS  - 5
SP  - 574
EP  - 581
PB  - Wiley-Blackwell
CY  - Hoboken, NJ
ER  - 
TY  - JOUR
A1  - Chung, Oliver
A1  - Vongpatanasin, Wanpen
A1  - Bonaventura, Klaus
A1  - Lotan, Yair
A1  - Sohns, Christian
A1  - Haverkamp, Wilhelm
A1  - Dorenkamp, Marc
T1  - Potential cost-effectiveness of therapeutic drug monitoring in patients with resistant hypertension
JF  - Journal of hypertension
N2  - Background: Nonadherence to drug therapy poses a significant problem in the treatment of patients with presumed resistant hypertension. It has been shown that therapeutic drug monitoring (TDM) is a useful tool for detecting nonadherence and identifying barriers to treatment adherence, leading to effective blood pressure (BP) control. However, the cost-effectiveness of TDM in the management of resistant hypertension has not been investigated.
 Results: In the age group of 60-year olds, TDM gained 1.07 QALYs in men and 0.97 QALYs in women at additional costs of (sic)3854 and (sic)3922, respectively. Given a willingness-to-pay threshold of (sic)35 000 per QALY gained, the probability of TDM being cost-effective was 95% or more in all age groups from 30 to 90 years. Results were influenced mostly by the frequency of TDM testing, the rate of nonresponders to TDM, and the magnitude of effect of TDM on BP.
 Conclusion: Therapeutic drug monitoring presents a potential cost-effective healthcare intervention in patients diagnosed with resistant hypertension. Importantly, this finding is valid for a wide range of patients, independent of sex and age.
KW  - cardiovascular diseases
KW  - cost and cost analysis
KW  - cost-benefit analysis
KW  - drug monitoring
KW  - hypertension
KW  - medication adherence
KW  - probability
KW  - risk assessment
Y1  - 2014
U6  - https://doi.org/10.1097/HJH.0000000000000346
SN  - 0263-6352
SN  - 1473-5598
VL  - 32
IS  - 12
SP  - 2411
EP  - 2421
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  -