TY  - JOUR
A1  - Hoie, Lars H.
A1  - Sjoholm, Ake
A1  - Guldstrand, Marie
A1  - Zunft, Hans-Joachim Franz
A1  - Lueder, Wolfgang
A1  - Graubaum, Hans-Joachim
A1  - Grünwald, Jörg
T1  - Ultra heat treatment destroys cholesterol-lowering effect of soy protein
JF  - International journal of food sciences and nutrition
N2  - A randomized, placebo-controlled, double-blind clinical study was performed to investigate the dose-dependent response of serum cholesterol after consuming an ultra-heat-treated milk containing a soy protein preparation. Eighty hypercholesterolemic subjects were assigned to one of four study groups receiving 12.5 or 25 g soy protein (active treatment) or casein (placebo) daily over a period of 4 weeks. The trial substances were provided as ready-made, ultra-heated milk preparations. Before and after the treatment, serum concentrations of total, low-density lipoprotein, and high-density lipoprotein cholesterol were determined. Unexpectedly, at the end of the study, low-density lipoprotein cholesterol concentrations were significantly increased compared with baseline in all study groups. The magnitude of this increase (17 - 19%) was similar in all active and placebo study groups. Soy protein supplements previously shown to be effective in reducing serum cholesterol had in this study no such lipid-lowering effect after ultra heat treatment.
KW  - soy
KW  - protein
KW  - cholesterol
KW  - ultra heat treatment
Y1  - 2006
U6  - https://doi.org/10.1080/09637480601009059
SN  - 0963-7486
VL  - 57
SP  - 512
EP  - 519
PB  - Taylor & Francis
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Hoie, Lars H.
A1  - Morgenstern, E. C. A.
A1  - Grünwald, Jörg
A1  - Graubaum, Hans-Joachim
A1  - Luder, W.
A1  - Zunft, Hans-Joachim Franz
T1  - Combining soy protein with phospholipids and fiber doubles the lipid-lowering effects compared with soy protein alone
Y1  - 2004
SN  - 0022-3166
ER  - 
TY  - JOUR
A1  - Hoie, Lars H.
A1  - Morgenstern, E. C. A.
A1  - Grünwald, Jörg
A1  - Graubaum, Hans-Joachim
A1  - Busch, R.
A1  - Luder, W.
A1  - Zunft, Hans-Joachim Franz
T1  - A double-blind placebo-controlled clinical trial compares the cholesterollowering effects of two different soy protein preparations in hypercholesterolemic subjects
N2  - Background Soy protein is effective in lowering plasma cholesterol, LDL cholesterol and triglyceride concentrations. It has not been conclusively answered, whether and to what extent other soy constituents may also contribute to this effect. Objective To investigate the change in blood lipid levels after application of two soy-based supplements containing soy protein either without (SuproSoy(R)) or with (Abacor(R)) soy fiber and phospholipids in a randomized placebo-controlled triple-armed study. Methods 121 hypercholesterolemic adults ( 66 females, 55 males) were recruited and randomly assigned to one of three treatments. Over 8 weeks they received daily either 25 g soy protein ( as a component of the supplements Abacor(R) or SuproSoy(R)) or 25 g milk protein ( as a component of placebo). Serum lipids were measured at baseline and after 4, 6 and 8 weeks. Results After 8 weeks of supplementation total cholesterol levels were reduced by 8.0 +/- 9.6% (Abacor(R)) and 3.4 +/- 8.3% (SuproSoy(R)); LDL cholesterol levels by 9.7 +/- 11.7% ( Abacor(R)) and 5.4 +/- 11.6% ( SuproSoy(R)); and Apolipoprotein B levels by 6.9 +/- 14.6% (Abacor(R)) and 4.0 +/- 12.4 % (SuproSoy(R)). Serum levels of HDL cholesterol and triglycerides remained unchanged. Conclusions A preparation combining isolated soy protein with soy fibers and phospholipids showed twice the lipid-lowering effect of a preparation containing isolated soy protein alone. Therefore, such soy-based supplements can be useful in reducing the cardiovascular risk
Y1  - 2005
SN  - 1436-6207
ER  -