TY  - JOUR
A1  - Brzezinka, Krzysztof
A1  - Altmann, Simone
A1  - Czesnick, Hjördis
A1  - Nicolas, Philippe
A1  - Gorka, Michal
A1  - Benke, Eileen
A1  - Kabelitz, Tina
A1  - Jähne, Felix
A1  - Graf, Alexander
A1  - Kappel, Christian
A1  - Bäurle, Isabel
T1  - Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling
JF  - eLife
N2  - Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress. We show that this heat stress memory requires the activity of the FORGETTER1 (FGT1) locus, with fgt1 mutants displaying reduced maintenance of heat-induced gene expression. FGT1 encodes the Arabidopsis thaliana orthologue of Strawberry notch (Sno), and the protein globally associates with the promoter regions of actively expressed genes in a heat-dependent fashion. FGT1 interacts with chromatin remodelers of the SWI/ SNF and ISWI families, which also display reduced heat stress memory. Genomic targets of the BRM remodeler overlap significantly with FGT1 targets. Accordingly, nucleosome dynamics at loci with altered maintenance of heat-induced expression are affected in fgt1. Together, our results suggest that by modulating nucleosome occupancy, FGT1 mediates stress-induced chromatin memory.
Y1  - 2016
U6  - https://doi.org/10.7554/eLife.17061
SN  - 2050-084X
VL  - 5
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -