TY - GEN A1 - Gamba, Cristina A1 - Jones, Eppie R. A1 - Teasdale, Matthew D. A1 - McLaughlin, Russell L. A1 - González-Fortes, Gloria M. A1 - Mattiangeli, Valeria A1 - Domboróczki, László A1 - Kővári, Ivett A1 - Pap, Ildikó A1 - Anders, Alexandra A1 - Whittle, Alasdair A1 - Dani, János A1 - Raczky, Pál A1 - Higham, Thomas F. G. A1 - Hofreiter, Michael A1 - Bradley, Daniel G. A1 - Pinhasi, Ron T1 - Genome flux and stasis in a five millennium transect of European prehistory T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (similar to 22x) and seven to similar to 1x coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1332 KW - ancient DNA KW - lactase-persistence KW - positive selection KW - patterns KW - sequence KW - farmers KW - pigmentation KW - homozygosity KW - ancestry KW - skin Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437999 SN - 1866-8372 VL - 5 IS - 1332 ER - TY - GEN A1 - Pajoro, Alice A1 - Madrigal, Pedro A1 - Muiño, Jose M. A1 - Matus, José Tomás A1 - Jin, Jian A1 - Mecchia, Martin A. A1 - Debernardi, Juan M. A1 - Palatnik, Javier F. A1 - Balazadeh, Salma A1 - Arif, Muhammad A1 - Ó’Maoiléidigh, Diarmuid S. A1 - Wellmer, Frank A1 - Krajewski, Pawel A1 - Riechmann, José-Luis A1 - Angenent, Gerco C. A1 - Kaufmann, Kerstin T1 - Dynamics of chromatin accessibility and gene regulation by MADS-domain transcription factors in flower development T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background: Development of eukaryotic organisms is controlled by transcription factors that trigger specific and global changes in gene expression programs. In plants, MADS-domain transcription factors act as master regulators of developmental switches and organ specification. However, the mechanisms by which these factors dynamically regulate the expression of their target genes at different developmental stages are still poorly understood. Results: We characterized the relationship of chromatin accessibility, gene expression, and DNA binding of two MADS-domain proteins at different stages of Arabidopsis flower development. Dynamic changes in APETALA1 and SEPALLATA3 DNA binding correlated with changes in gene expression, and many of the target genes could be associated with the developmental stage in which they are transcriptionally controlled. We also observe dynamic changes in chromatin accessibility during flower development. Remarkably, DNA binding of APETALA1 and SEPALLATA3 is largely independent of the accessibility status of their binding regions and it can precede increases in DNA accessibility. These results suggest that APETALA1 and SEPALLATA3 may modulate chromatin accessibility, thereby facilitating access of other transcriptional regulators to their target genes. Conclusions: Our findings indicate that different homeotic factors regulate partly overlapping, yet also distinctive sets of target genes in a partly stage-specific fashion. By combining the information from DNA-binding and gene expression data, we are able to propose models of stage-specific regulatory interactions, thereby addressing dynamics of regulatory networks throughout flower development. Furthermore, MADS-domain TFs may regulate gene expression by alternative strategies, one of which is modulation of chromatin accessibility. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1327 KW - flower development KW - floral organ KW - floral meristem KW - chromatin accessibility KW - growth regulate factor Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431139 SN - 1866-8372 VL - 15 ER - TY - JOUR A1 - Dorsch, Christian A1 - Dörfler, Thomas T1 - Organized hypocrisy of the international community BT - an institutionalist explanation of the UN security council’s contradictory activity on darfur JF - Zeitschrift für Genozidforschung Y1 - 2014 U6 - https://doi.org/10.5771/1438-8332-2014-1-2-8 SN - 1438-8332 SN - 2589-1510 VL - 15 IS - 1-2 SP - 8 EP - 31 PB - Velbrück Wissenschaft CY - Weilerswist ER - TY - GEN A1 - Bald, Ilko A1 - Keller, Adrian T1 - Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1146 KW - DNA origami KW - atomic force microscopy KW - single-molecule analysis KW - DNA radiation damage KW - protein binding KW - enzyme reactions KW - G quadruplexes Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-475843 SN - 1866-8372 IS - 9 SP - 13803 EP - 13823 ER - TY - GEN A1 - Hildebrandt, Dieter T1 - A software reference architecture for service-oriented 3D geovisualization systems T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Modern 3D geovisualization systems (3DGeoVSs) are complex and evolving systems that are required to be adaptable and leverage distributed resources, including massive geodata. This article focuses on 3DGeoVSs built based on the principles of service-oriented architectures, standards and image-based representations (SSI) to address practically relevant challenges and potentials. Such systems facilitate resource sharing and agile and efficient system construction and change in an interoperable manner, while exploiting images as efficient, decoupled and interoperable representations. The software architecture of a 3DGeoVS and its underlying visualization model have strong effects on the system's quality attributes and support various system life cycle activities. This article contributes a software reference architecture (SRA) for 3DGeoVSs based on SSI that can be used to design, describe and analyze concrete software architectures with the intended primary benefit of an increase in effectiveness and efficiency in such activities. The SRA integrates existing, proven technology and novel contributions in a unique manner. As the foundation for the SRA, we propose the generalized visualization pipeline model that generalizes and overcomes expressiveness limitations of the prevalent visualization pipeline model. To facilitate exploiting image-based representations (IReps), the SRA integrates approaches for the representation, provisioning and styling of and interaction with IReps. Five applications of the SRA provide proofs of concept for the general applicability and utility of the SRA. A qualitative evaluation indicates the overall suitability of the SRA, its applications and the general approach of building 3DGeoVSs based on SSI. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1131 KW - 3D geovisualization KW - software reference architecture KW - spatial data infrastructure KW - service-oriented architecture KW - standardization KW - image-based representation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-475831 SN - 1866-8372 IS - 1131 ER - TY - GEN A1 - Küttner, Uwe-Alexander T1 - Rhythmic analyses as a proof-procedure? BT - An initial observation on rhythmicity and projection T2 - Postprints der Universität Potsdam : Philosophische Reihe N2 - This paper reports a problematic case of unequivocally evidencing participant orientation to the projective force of some turn-initial demonstrative wh-clefts (DCs) within the framework of Conversation Analysis (CA) and Interactional Linguistics (IL). Conducting rhythmic analyses appears helpful in this regard, in that they disclose rhythmic regularities which suggest a speaker's orientation towards a projected turn continuation. In this particular case, rhythmic analyses can therefore be shown to meaningfully complement sequential analyses and analyses of turn-design, so as to gather additional evidence for participant orientations. In conclusion, I will point to possibly more extensive relations between rhythmicity and projection and proffer a tentative outlook for the usability of rhythmic analyses as an analytic tool in CA and IL. T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 172 KW - Interactional Linguistics KW - Speech Rhythm and Rhythmic Analysis KW - Method KW - Participant Orientation KW - Turn-Constructional Units KW - Projection KW - Demonstrative Clefts Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-445363 SN - 1866-8380 IS - 172 ER - TY - GEN A1 - Huynen, Leon A1 - Suzuki, Takayuki A1 - Ogura, Toshihiko A1 - Watanabe, Yusuke A1 - Millar, Craig D. A1 - Hofreiter, Michael A1 - Smith, Craig A1 - Mirmoeini, Sara A1 - Lambert, David M. T1 - Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes) T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background The forelimb-specific gene tbx5 is highly conserved and essential for the development of forelimbs in zebrafish, mice, and humans. Amongst birds, a single order, Dinornithiformes, comprising the extinct wingless moa of New Zealand, are unique in having no skeletal evidence of forelimb-like structures. Results To determine the sequence of tbx5 in moa, we used a range of PCR-based techniques on ancient DNA to retrieve all nine tbx5 exons and splice sites from the giant moa, Dinornis. Moa Tbx5 is identical to chicken Tbx5 in being able to activate the downstream promotors of fgf10 and ANF. In addition we show that missexpression of moa tbx5 in the hindlimb of chicken embryos results in the formation of forelimb features, suggesting that Tbx5 was fully functional in wingless moa. An alternatively spliced exon 1 for tbx5 that is expressed specifically in the forelimb region was shown to be almost identical between moa and ostrich, suggesting that, as well as being fully functional, tbx5 is likely to have been expressed normally in moa since divergence from their flighted ancestors, approximately 60 mya. Conclusions The results suggests that, as in mice, moa tbx5 is necessary for the induction of forelimbs, but is not sufficient for their outgrowth. Moa Tbx5 may have played an important role in the development of moa’s remnant forelimb girdle, and may be required for the formation of this structure. Our results further show that genetic changes affecting genes other than tbx5 must be responsible for the complete loss of forelimbs in moa. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1117 KW - tbx5 KW - Moa KW - gene expression KW - ancient DNA KW - development KW - forelimb Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431599 SN - 1866-8372 IS - 1117 ER - TY - JOUR A1 - Badalyan, Artavazd A1 - Dierich, Marlen A1 - Stiba, Konstanze A1 - Schwuchow, Viola A1 - Leimkühler, Silke A1 - Wollenberger, Ulla T1 - Electrical wiring of the aldehyde oxidoreductase PaoABC with a polymer containing osmium redox centers BT - biosensors for benzaldehyde and GABA JF - Biosensors N2 - Biosensors for the detection of benzaldehyde and g-aminobutyric acid (GABA) are reported using aldehyde oxidoreductase PaoABC from Escherichia coli immobilized in a polymer containing bound low potential osmium redox complexes. The electrically connected enzyme already electrooxidizes benzaldehyde at potentials below −0.15 V (vs. Ag|AgCl, 1 M KCl). The pH-dependence of benzaldehyde oxidation can be strongly influenced by the ionic strength. The effect is similar with the soluble osmium redox complex and therefore indicates a clear electrostatic effect on the bioelectrocatalytic efficiency of PaoABC in the osmium containing redox polymer. At lower ionic strength, the pH-optimum is high and can be switched to low pH-values at high ionic strength. This offers biosensing at high and low pH-values. A “reagentless” biosensor has been formed with enzyme wired onto a screen-printed electrode in a flow cell device. The response time to addition of benzaldehyde is 30 s, and the measuring range is between 10–150 µM and the detection limit of 5 µM (signal to noise ratio 3:1) of benzaldehyde. The relative standard deviation in a series (n = 13) for 200 µM benzaldehyde is 1.9%. For the biosensor, a response to succinic semialdehyde was also identified. Based on this response and the ability to work at high pH a biosensor for GABA is proposed by coimmobilizing GABA-aminotransferase (GABA-T) and PaoABC in the osmium containing redox polymer. KW - redox polymer KW - aldehyde oxidoreductase KW - ionic strength KW - benzaldehyde KW - GABA KW - biosensor Y1 - 2014 U6 - https://doi.org/10.3390/bios4040403 VL - 4 IS - 4 SP - 403 EP - 421 PB - MDPI CY - Basel ER - TY - GEN A1 - Badalyan, Artavazd A1 - Dierich, Marlen A1 - Stiba, Konstanze A1 - Schwuchow, Viola A1 - Leimkühler, Silke A1 - Wollenberger, Ulla T1 - Electrical wiring of the aldehyde oxidoreductase PaoABC with a polymer containing osmium redox centers BT - biosensors for benzaldehyde and GABA T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Biosensors for the detection of benzaldehyde and g-aminobutyric acid (GABA) are reported using aldehyde oxidoreductase PaoABC from Escherichia coli immobilized in a polymer containing bound low potential osmium redox complexes. The electrically connected enzyme already electrooxidizes benzaldehyde at potentials below −0.15 V (vs. Ag|AgCl, 1 M KCl). The pH-dependence of benzaldehyde oxidation can be strongly influenced by the ionic strength. The effect is similar with the soluble osmium redox complex and therefore indicates a clear electrostatic effect on the bioelectrocatalytic efficiency of PaoABC in the osmium containing redox polymer. At lower ionic strength, the pH-optimum is high and can be switched to low pH-values at high ionic strength. This offers biosensing at high and low pH-values. A “reagentless” biosensor has been formed with enzyme wired onto a screen-printed electrode in a flow cell device. The response time to addition of benzaldehyde is 30 s, and the measuring range is between 10–150 µM and the detection limit of 5 µM (signal to noise ratio 3:1) of benzaldehyde. The relative standard deviation in a series (n = 13) for 200 µM benzaldehyde is 1.9%. For the biosensor, a response to succinic semialdehyde was also identified. Based on this response and the ability to work at high pH a biosensor for GABA is proposed by coimmobilizing GABA-aminotransferase (GABA-T) and PaoABC in the osmium containing redox polymer. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1082 KW - redox polymer KW - aldehyde oxidoreductase KW - ionic strength KW - benzaldehyde KW - GABA KW - biosensor Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-475070 SN - 1866-8372 IS - 1082 ER - TY - GEN A1 - Vioux, André A1 - Taubert, Andreas T1 - Ionic liquids 2014 and selected papers from ILMAT 2013 BT - Highlighting the ever-growing potential of Ionic Liquids T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1055 KW - electrolytes KW - extraction KW - system Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-475062 SN - 1866-8372 IS - 1055 ER - TY - GEN A1 - Yarman, Aysu A1 - Scheller, Frieder W. T1 - The first electrochemical MIP sensor for tamoxifen T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - We present an electrochemical MIP sensor for tamoxifen (TAM)-a nonsteroidal anti-estrogen-which is based on the electropolymerisation of an O-phenylenediamine. resorcinol mixture directly on the electrode surface in the presence of the template molecule. Up to now only. bulk. MIPs for TAM have been described in literature, which are applied for separation in chromatography columns. Electro-polymerisation of the monomers in the presence of TAM generated a film which completely suppressed the reduction of ferricyanide. Removal of the template gave a markedly increased ferricyanide signal, which was again suppressed after rebinding as expected for filling of the cavities by target binding. The decrease of the ferricyanide peak of the MIP electrode depended linearly on the TAM concentration between 1 and 100 nM. The TAM-imprinted electrode showed a 2.3 times higher recognition of the template molecule itself as compared to its metabolite 4-hydroxytamoxifen and no cross-reactivity with the anticancer drug doxorubucin was found. Measurements at + 1.1 V caused a fouling of the electrode surface, whilst pretreatment of TAM with peroxide in presence of HRP generated an oxidation product which was reducible at 0 mV, thus circumventing the polymer formation and electrochemical interferences. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1046 KW - molecularly imprinted polymers KW - anticancer drug KW - tamoxifen KW - electropolymerisation Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-476173 SN - 1866-8372 IS - 1046 ER - TY - GEN A1 - Laschewsky, André T1 - Structures and synthesis of zwitterionic polymers T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The structures and synthesis of polyzwitterions ("polybetaines") are reviewed, emphasizing the literature of the past decade. Particular attention is given to the general challenges faced, and to successful strategies to obtain polymers with a true balance of permanent cationic and anionic groups, thus resulting in an overall zero charge. Also, the progress due to applying new methodologies from general polymer synthesis, such as controlled polymerization methods or the use of "click" chemical reactions is presented. Furthermore, the emerging topic of responsive ("smart") polyzwitterions is addressed. The considerations and critical discussions are illustrated by typical examples. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1043 KW - review KW - polyzwitterion KW - polyampholyte KW - zwitterionic group KW - betaine KW - synthesis KW - monomer KW - polymerization KW - post-polymerization modification Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-476167 SN - 1866-8372 IS - 1043 ER - TY - GEN A1 - Hägele, Claudia A1 - Schlagenhauf, Florian A1 - Rapp, Michael A. A1 - Sterzer, Philipp A1 - Beck, Anne A1 - Bermpohl, Felix A1 - Stoy, Meline A1 - Ströhle, Andreas A1 - Wittchen, Hans-Ulrich A1 - Dolan, Raymond J. A1 - Heinz, Andreas T1 - Dimensional psychiatry BT - reward dysfunction and depressive mood across psychiatric disorders T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. We used functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task to study the functional correlates of reward anticipation across major psychiatric disorders in 184 subjects, with the diagnoses of alcohol dependence (n = 26), schizophrenia (n = 44), major depressive disorder (MDD, n = 24), bipolar disorder (acute manic episode, n = 13), attention deficit/hyperactivity disorder (ADHD, n = 23), and healthy controls (n = 54). Subjects' individual Beck Depression Inventory-and State-Trait Anxiety Inventory-scores were correlated with clusters showing significant activation during reward anticipation. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 653 KW - dimensional KW - fMRI KW - reward system KW - ventral striatum KW - monetary incentive delay task KW - depressive symptoms Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431064 SN - 1866-8364 IS - 653 SP - 331 EP - 341 ER - TY - GEN A1 - Kersting, Sebastian A1 - Rausch, Valentina A1 - Bier, Frank Fabian A1 - von Nickisch-Rosenegk, Markus T1 - Rapid detection of Plasmodium falciparum with isothermal recombinase polymerase amplification and lateral flow analysis T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Background Nucleic acid amplification is the most sensitive and specific method to detect Plasmodium falciparum. However the polymerase chain reaction remains laboratory-based and has to be conducted by trained personnel. Furthermore, the power dependency for the thermocycling process and the costly equipment necessary for the read-out are difficult to cover in resource-limited settings. This study aims to develop and evaluate a combination of isothermal nucleic acid amplification and simple lateral flow dipstick detection of the malaria parasite for point-of-care testing. Methods A specific fragment of the 18S rRNA gene of P. falciparum was amplified in 10 min at a constant 38°C using the isothermal recombinase polymerase amplification (RPA) method. With a unique probe system added to the reaction solution, the amplification product can be visualized on a simple lateral flow strip without further labelling. The combination of these methods was tested for sensitivity and specificity with various Plasmodium and other protozoa/bacterial strains, as well as with human DNA. Additional investigations were conducted to analyse the temperature optimum, reaction speed and robustness of this assay. Results The lateral flow RPA (LF-RPA) assay exhibited a high sensitivity and specificity. Experiments confirmed a detection limit as low as 100 fg of genomic P. falciparum DNA, corresponding to a sensitivity of approximately four parasites per reaction. All investigated P. falciparum strains (n = 77) were positively tested while all of the total 11 non-Plasmodium samples, showed a negative test result. The enzymatic reaction can be conducted under a broad range of conditions from 30-45°C with high inhibitory concentration of known PCR inhibitors. A time to result of 15 min from start of the reaction to read-out was determined. Conclusions Combining the isothermal RPA and the lateral flow detection is an approach to improve molecular diagnostic for P. falciparum in resource-limited settings. The system requires none or only little instrumentation for the nucleic acid amplification reaction and the read-out is possible with the naked eye. Showing the same sensitivity and specificity as comparable diagnostic methods but simultaneously increasing reaction speed and dramatically reducing assay requirements, the method has potential to become a true point-of-care test for the malaria parasite. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 948 KW - Plasmodium falciparum KW - Recombinase polymerase amplification KW - RPA KW - PCR KW - lateral flow KW - point-of-care testing KW - rapid test KW - isothermal nucleic acid amplification Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431562 SN - 1866-8372 IS - 948 ER - TY - GEN A1 - Thieken, Annegret A1 - Cammerer, Holger A1 - Dobler, Christian A1 - Lammel, Johannes A1 - Schöberl, Fritz T1 - Estimating changes in flood risks and benefits of non-structural adaptation strategies BT - a case study from Tyrol, Austria T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Flood damage has increased significantly and is expected to rise further in many parts of the world. For assessing potential changes in flood risk, this paper presents an integrated model chain quantifying flood hazards and losses while considering climate and land use changes. In the case study region, risk estimates for the present and the near future illustrate that changes in flood risk by 2030 are relatively low compared to historic periods. While the impact of climate change on the flood hazard and risk by 2030 is slight or negligible, strong urbanisation associated with economic growth contributes to a remarkable increase in flood risk. Therefore, it is recommended to frequently consider land use scenarios and economic developments when assessing future flood risks. Further, an adapted and sustainable risk management is necessary to encounter rising flood losses, in which non-structural measures are becoming more and more important. The case study demonstrates that adaptation by non-structural measures such as stricter land use regulations or enhancement of private precaution is capable of reducing flood risk by around 30 %. Ignoring flood risks, in contrast, always leads to further increasing losses-with our assumptions by 17 %. These findings underline that private precaution and land use regulation could be taken into account as low cost adaptation strategies to global climate change in many flood prone areas. Since such measures reduce flood risk regardless of climate or land use changes, they can also be recommended as no-regret measures. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 910 KW - flood risk KW - scenarios KW - adaptation to climate change KW - hazard KW - vulnerability KW - lech catchment Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432282 SN - 1866-8372 IS - 910 ER - TY - GEN A1 - Böckmann, Christine A1 - Osterloh, Lukas T1 - Runge-Kutta type regularization method for inversion of spheroidal particle distribution from limited optical data T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The Runge-Kutta type regularization method was recently proposed as a potent tool for the iterative solution of nonlinear ill-posed problems. In this paper we analyze the applicability of this regularization method for solving inverse problems arising in atmospheric remote sensing, particularly for the retrieval of spheroidal particle distribution. Our numerical simulations reveal that the Runge-Kutta type regularization method is able to retrieve two-dimensional particle distributions using optical backscatter and extinction coefficient profiles, as well as depolarization information. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 907 KW - inverse ill-posed problem KW - integral equation KW - laser remote sensing KW - inverse scattering KW - aerosol size distribution KW - 65R32 KW - 47A52 KW - 65R20 KW - 78A46 KW - iterative regularization Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441200 SN - 1866-8372 IS - 907 SP - 150 EP - 165 ER - TY - GEN A1 - Wang, Lifeng A1 - Zöller, Gert A1 - Hainzl, Sebastian T1 - Joint determination of slip and stress drop in a Bayesian inversion approach: BT - a case study for the 2010 M8.8 Maule earthquake T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Stress drop is a key factor in earthquake mechanics and engineering seismology. However, stress drop calculations based on fault slip can be significantly biased, particularly due to subjectively determined smoothing conditions in the traditional least-square slip inversion. In this study, we introduce a mechanically constrained Bayesian approach to simultaneously invert for fault slip and stress drop based on geodetic measurements. A Gaussian distribution for stress drop is implemented in the inversion as a prior. We have done several synthetic tests to evaluate the stability and reliability of the inversion approach, considering different fault discretization, fault geometries, utilized datasets, and variability of the slip direction, respectively. We finally apply the approach to the 2010 M8.8 Maule earthquake and invert for the coseismic slip and stress drop simultaneously. Two fault geometries from the literature are tested. Our results indicate that the derived slip models based on both fault geometries are similar, showing major slip north of the hypocenter and relatively weak slip in the south, as indicated in the slip models of other studies. The derived mean stress drop is 5-6 MPa, which is close to the stress drop of similar to 7 MPa that was independently determined according to force balance in this region Luttrell et al. (J Geophys Res, 2011). These findings indicate that stress drop values can be consistently extracted from geodetic data. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 888 KW - stress drop KW - fault slip KW - Bayesian KW - geodetic measurements Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435511 SN - 1866-8372 IS - 888 SP - 375 EP - 388 ER - TY - GEN A1 - Wallenta, Daniel T1 - A Lefschetz fixed point formula for elliptic quasicomplexes T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - In a recent paper, the Lefschetz number for endomorphisms (modulo trace class operators) of sequences of trace class curvature was introduced. We show that this is a well defined, canonical extension of the classical Lefschetz number and establish the homotopy invariance of this number. Moreover, we apply the results to show that the Lefschetz fixed point formula holds for geometric quasiendomorphisms of elliptic quasicomplexes. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 885 KW - elliptic complexes KW - Fredholm complexes KW - Lefschetz number Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435471 SN - 1866-8372 IS - 885 SP - 577 EP - 587 ER - TY - GEN A1 - Arni, Patrick A1 - Caliendo, Marco A1 - Künn, Steffen A1 - Zimmermann, Klaus F. T1 - The IZA evaluation dataset survey BT - a scientific use file T2 - Postprints der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe N2 - This reference paper describes the sampling and contents of the IZA Evaluation Dataset Survey and outlines its vast potential for research in labor economics. The data have been part of a unique IZA project to connect administrative data from the German Federal Employment Agency with innovative survey data to study the out-mobility of individuals to work. This study makes the survey available to the research community as a Scientific Use File by explaining the development, structure, and access to the data. Furthermore, it also summarizes previous findings with the survey data. T3 - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 122 KW - survey data KW - scientific use file KW - labor market policies KW - evaluation KW - migration KW - ethnicity KW - attitudes KW - behavior KW - skills Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435204 SN - 1867-5808 IS - 122 ER - TY - GEN A1 - Friedel, Eva A1 - Schlagenhauf, Florian A1 - Beck, Anne A1 - Dolan, Raymond J. A1 - Huys, Quentin J. M. A1 - Rapp, Michael A. A1 - Heinz, Andreas T1 - The effects of life stress and neural learning signals on fluid intelligence T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Fluid intelligence (fluid IQ), defined as the capacity for rapid problem solving and behavioral adaptation, is known to be modulated by learning and experience. Both stressful life events (SLES) and neural correlates of learning [specifically, a key mediator of adaptive learning in the brain, namely the ventral striatal representation of prediction errors (PE)] have been shown to be associated with individual differences in fluid IQ. Here, we examine the interaction between adaptive learning signals (using a well-characterized probabilistic reversal learning task in combination with fMRI) and SLES on fluid IQ measures. We find that the correlation between ventral striatal BOLD PE and fluid IQ, which we have previously reported, is quantitatively modulated by the amount of reported SLES. Thus, after experiencing adversity, basic neuronal learning signatures appear to align more closely with a general measure of flexible learning (fluid IQ), a finding complementing studies on the effects of acute stress on learning. The results suggest that an understanding of the neurobiological correlates of trait variables like fluid IQ needs to take socioemotional influences such as chronic stress into account. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 621 KW - reinforcement learning KW - prediction error signal KW - ventral striatum KW - stress KW - intelligence Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-435140 SN - 1866-8372 IS - 621 SP - 35 EP - 43 ER - TY - GEN A1 - Zulawski, Monika A1 - Schulze, Gunnar A1 - Braginets, Rostyslav A1 - Hartmann, Stefanie A1 - Schulze, Waltraud X T1 - The Arabidopsis Kinome BT - phylogeny and evolutionary insights into functional diversification T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Background Protein kinases constitute a particularly large protein family in Arabidopsis with important functions in cellular signal transduction networks. At the same time Arabidopsis is a model plant with high frequencies of gene duplications. Here, we have conducted a systematic analysis of the Arabidopsis kinase complement, the kinome, with particular focus on gene duplication events. We matched Arabidopsis proteins to a Hidden-Markov Model of eukaryotic kinases and computed a phylogeny of 942 Arabidopsis protein kinase domains and mapped their origin by gene duplication. Results The phylogeny showed two major clades of receptor kinases and soluble kinases, each of which was divided into functional subclades. Based on this phylogeny, association of yet uncharacterized kinases to families was possible which extended functional annotation of unknowns. Classification of gene duplications within these protein kinases revealed that representatives of cytosolic subfamilies showed a tendency to maintain segmentally duplicated genes, while some subfamilies of the receptor kinases were enriched for tandem duplicates. Although functional diversification is observed throughout most subfamilies, some instances of functional conservation among genes transposed from the same ancestor were observed. In general, a significant enrichment of essential genes was found among genes encoding for protein kinases. Conclusions The inferred phylogeny allowed classification and annotation of yet uncharacterized kinases. The prediction and analysis of syntenic blocks and duplication events within gene families of interest can be used to link functional biology to insights from an evolutionary viewpoint. The approach undertaken here can be applied to any gene family in any organism with an annotated genome. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 861 KW - Hide Markov Model KW - Duplication Event KW - Kinase Family KW - Tandem Duplication KW - Segmental Duplication Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432907 SN - 1866-8372 IS - 861 ER - TY - GEN A1 - Kibele, Armin A1 - Classen, Claudia A1 - Mühlbauer, Thomas A1 - Granacher, Urs A1 - Behm, David George T1 - Metastability in plyometric training on unstable surfaces BT - a pilot study T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background In the past, plyometric training (PT) has been predominantly performed on stable surfaces. The purpose of this pilot study was to examine effects of a 7-week lower body PT on stable vs. unstable surfaces. This type of exercise condition may be denoted as metastable equilibrium. Methods Thirty-three physically active male sport science students (age: 24.1 ± 3.8 years) were randomly assigned to a PT group (n = 13) exercising on stable (STAB) and a PT group (n = 20) on unstable surfaces (INST). Both groups trained countermovement jumps, drop jumps, and practiced a hurdle jump course. In addition, high bar squats were performed. Physical fitness tests on stable surfaces (hexagonal obstacle test, countermovement jump, hurdle drop jump, left-right hop, dynamic and static balance tests, and leg extension strength) were used to examine the training effects. Results Significant main effects of time (ANOVA) were found for the countermovement jump, hurdle drop jump, hexagonal test, dynamic balance, and leg extension strength. A significant interaction of time and training mode was detected for the countermovement jump in favor of the INST group. No significant improvements were evident for either group in the left-right hop and in the static balance test. Conclusions These results show that lower body PT on unstable surfaces is a safe and efficient way to improve physical performance on stable surfaces. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 606 KW - instability resistance training KW - stretch-shortening cycle KW - physical fitness test KW - balance training Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-429013 SN - 1866-8364 IS - 606 ER - TY - RPRT A1 - Küttner, Uwe-Alexander T1 - Opening Up CA – An Interactional Linguist’s View on ICCA-14 T2 - Gesprächsforschung : Online-Zeitschrift zur verbalen Interaktion Y1 - 2015 UR - http://www.gespraechsforschung-online.de/fileadmin/dateien/heft2014/tb-kuettner.pdf SN - 1617-1837 IS - 15 SP - 264 EP - 289 PB - Verlag für Gesprächsforschung CY - Mannheim ER - TY - JOUR A1 - Küttner, Uwe-Alexander T1 - Rhythmic analyses as a proof-procedure? BT - An initial observation on rhythmicity and projection JF - Prosodie und Phonetik in der Interaktion = Prosody and phonetics in interaction N2 - This paper reports a problematic case of unequivocally evidencing participant orientation to the projective force of some turn-initial demonstrative wh-clefts (DCs) within the framework of Conversation Analysis (CA) and Interactional Linguistics (IL). Conducting rhythmic analyses appears helpful in this regard, in that they disclose rhythmic regularities which suggest a speaker's orientation towards a projected turn continuation. In this particular case, rhythmic analyses can therefore be shown to meaningfully complement sequential analyses and analyses of turn-design, so as to gather additional evidence for participant orientations. In conclusion, I will point to possibly more extensive relations between rhythmicity and projection and proffer a tentative outlook for the usability of rhythmic analyses as an analytic tool in CA and IL. N2 - Dieser primär interaktional-linguistisch ausgerichtete Beitrag berichtet von einem Problemfall im Nachweis von Teilnehmerorientierung an den Turn-Fortführung projizierenden Eigenschaften einiger turn-initialer "Demonstrative-Cleft- Konstruktionen" (DCs). Es wird gezeigt, dass rhythmische Analysen diesbezüglich hilfreich sein können, da sie im konkreten Fall rhythmische Regularitäten erkennen lassen, die eine sprecherseitige Orientierung an einer projizierten Turn-Fortführung nahelegen. Vorausgegangene sequenzielle Analysen und Analysen von Turn-Design werden somit bedeutsam durch rhythmische Analysen ergänzt, um zusätzliche Evidenzen für Teilnehmerorientierungen zu erfassen. Abschließend werde ich auf potenziell weitreichendere Zusammenhänge zwischen Rhythmizität und Projektion in der Interaktion hinweisen und einen provisorischen Ausblick hinsichtlich der möglichen Verwendung rhythmischer Analysen als Analysewerkzeug in der Konversationsanalyse und der Interaktionalen Linguistik geben. KW - Interaktionale Linguistik KW - Sprechrhythmus und Rhythmische Analyse KW - Methode KW - Teilnehmerorientierung KW - Turnkonstruktionseinheiten KW - Projektion KW - Demonstrative Clefts KW - Interactional Linguistics KW - Speech Rhythm and Rhythmic Analysis KW - Method KW - Participant Orientation KW - Turn-Constructional Units KW - Projection KW - Demonstrative Clefts Y1 - 2014 UR - http://verlag-gespraechsforschung.de/2014/pdf/kuettner-audio.pdf SN - 978-3-936656-60-2 SP - 46 EP - 69 PB - Verlag für Gesprächsforschung CY - Mannheim ER - TY - GEN A1 - Morel, T. A1 - Castro, Norberto A1 - Fossati, Luca A1 - Hubrig, Swetlana A1 - Langer, N. A1 - Przybilla, Norbert A1 - Schöller, Markus A1 - Carroll, Thorsten Anthony A1 - Ilyin, Ilya A1 - Irrgang, Andreas A1 - Oskinova, Lidia M. A1 - Schneider, Fabian R. N. A1 - Simon Díaz, Sergio A1 - Briquet, Maryline A1 - González, Jean-Francois A1 - Kharchenko, Nina A1 - Nieva, M.-F. A1 - Scholz, Ralf-Dieter A1 - de Koter, Alexander A1 - Hamann, Wolf-Rainer A1 - Herrero, Artemio A1 - Maíz Apellániz, Jesus A1 - Sana, Hugues A1 - Arlt, Rainer A1 - Barbá, Rodolfo H. A1 - Dufton, Polly A1 - Kholtygin, Alexander A1 - Mathys, Gautier A1 - Piskunov, Anatoly E. A1 - Reisenegger, Andreas A1 - Spruit, H. A1 - Yoon, S.-C. T1 - The B fields in OB stars (BOB) survey T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The B fields in OB stars (BOB) survey is an ESO large programme collecting spectropolarimetric observations for a large number of early-type stars in order to study the occurrence rate, properties, and ultimately the origin of magnetic fields in massive stars. As of July 2014, a total of 98 objects were observed over 20 nights with FORS2 and HARPSpol. Our preliminary results indicate that the fraction of magnetic OB stars with an organised, detectable field is low. This conclusion, now independently reached by two different surveys, has profound implications for any theoretical model attempting to explain the field formation in these objects. We discuss in this contribution some important issues addressed by our observations (e.g., the lower bound of the field strength) and the discovery of some remarkable objects. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 821 KW - magnetic fields KW - stars: early-type KW - stars: magnetic fields KW - stars: individual (HD 164492C, CPD –57 ◦ 3509, HD 54879, β CMa, ε CMa) Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415238 SN - 1866-8372 IS - 821 ER - TY - GEN A1 - Ehrig, Hartmut A1 - Golas, Ulrike A1 - Habel, Annegret A1 - Lambers, Leen A1 - Orejas, Fernando T1 - M-adhesive transformation systems with nested application conditions BT - Part 1: parallelism, concurrency and amalgamation T2 - Postprints der Universität Potsdam : Digital Engineering Reihe N2 - Nested application conditions generalise the well-known negative application conditions and are important for several application domains. In this paper, we present Local Church-Rosser, Parallelism, Concurrency and Amalgamation Theorems for rules with nested application conditions in the framework of M-adhesive categories, where M-adhesive categories are slightly more general than weak adhesive high-level replacement categories. Most of the proofs are based on the corresponding statements for rules without application conditions and two shift lemmas stating that nested application conditions can be shifted over morphisms and rules. T3 - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 1 KW - level-replacement systems KW - graph-transformations KW - distributed systems KW - synchronization KW - confluence KW - categories KW - programs KW - grammars KW - model Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415651 IS - 001 ER - TY - CHAP A1 - Demske, Ulrike A1 - Logacev, Pavel A1 - Goldschmidt, Katrin T1 - POS-Tagging Historical Corpora: The Case of Early New High German T2 - Proceedings of the thirteenth workshop on treebanks and linguistic theories (TLT 13) N2 - A key problem in automatic annotation of historical corpora is inconsistent spelling. Because the spelling of some word forms can differ between texts, a language model trained on already annotated treebanks may fail to recognize known word forms due to differences in spelling. In the present work, we explore the feasibility of an unsupervised method for spelling-adjustment for the purpose of improved part of speech (POS) tagging. To this end, we present a method for spelling normalization based on weighted edit distances, which exploits within-text spelling variation. We then evaluate the improvement in taging accuracy resulting from between-texts spelling normalization in two tagging experiments on several Early New High German (ENHG) texts. Y1 - 2014 VL - 2014 SP - 103 EP - 112 PB - TALAR - Tübingen Archive of Language Resources CY - Tübingen ER - TY - JOUR A1 - Ifenthaler, Dirk T1 - Challenges of a Holistic Learning Analytics Project JF - E-Learning Symposium 2014 : Mobil und vernetzt – studieren im digitalen Zeitalter ; Potsdam, 14. November 2014 N2 - Recently, interest in collecting and mining large sets of educational data on student background and performance to conduct research on learning and instruction has developed as an area generally referred to as learning analytics. Higher education leaders are recognising the value of learning analytics for improving not only learning and teaching but also the entire educational arena. However, theoretical concepts and empirical evidence need to be generated within the fast evolving field of learning analytics. In this paper, we introduce a holistic learning analytics framework. Based on this framework, student, learning, and curriculum profiles have been developed which include relevant static and dynamic parameters for facilitating the learning analytics framework. Based on the theoretical model, an empirical study was conducted to empirically validate the parameters included in the student profile. The paper concludes with practical implications and issues for future research. Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442303 SP - 15 EP - 28 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Wilkens, Martin A1 - Sütterlin, Sabine A1 - Kampe, Heike A1 - Eckardt, Barbara A1 - Jäger, Sophie A1 - Zimmermann, Matthias T1 - Portal Wissen = Time BT - The Research Magazine of the University of Potsdam N2 - “What then is time?”, Augustine of Hippo sighs melancholically in Book XI of “Confessions” and continues, “If no one asks me, I know; if I want to explain it to a questioner, I don’t know.” Even today, 1584 years after Augustine, time still appears mysterious. Treatises about the essence of time fill whole libraries – and this magazine. However, questions of essence are alien to modern sciences. Time is – at least in physics – unproblematic: “Time is defined so that motion looks simple”, briefly and prosaically phrased, waves goodbye to Augustine’s riddle and to the Newtonian concept of absolute time, whose mathematical flow can only be approximately recorded with earthly instruments anyway. In our everyday language and even in science we still speak of the flow of time but time has not been a natural condition for quite a while now. It is rather a conventional order parameter for change and movement. Processes are arranged by using a class of processes as a counting system in order to compare other processes and to organize them with the help of the temporary categories “before”, “during”, and “after”. During Galileo’s time one’s own pulse was seen as the time standard for the flight of cannon balls. More sophisticated examination methods later made this seem too impractical. The distance-time diagrams of free-flying cannon balls turned out to be rather imprecise, difficult to replicate, and in no way “simple”. Nowadays, we use cesium atoms. A process is said to take one second when a caesium-133 atom completes 9,192,631,770 periods of the radiation corresponding to the transition between two hyperfine levels of the ground state. A meter is the length of the path travelled by light in a vacuum in exactly 1/299,792,458 of a second. Fortunately, these data are hard-coded in the Global Positioning System GPS so users do not have to reenter them each time they want to know where they are. In the future, however, they might have to download an app because the time standard has been replaced by sophisticated transitions to ytterbium. The conventional character of the time concept should not tempt us to believe that everything is somehow relative and, as a result, arbitrary. The relation of one’s own pulse to an atomic clock is absolute and as real as the relation of an hourglass to the path of the sun. The exact sciences are relational sciences. They are not about the thing-initself as Newton and Kant dreamt, but rather about relations as Leibniz and, later, Mach pointed out. It is not surprising that the physical time standard turned out to be rather impractical for other scientists. The psychology of time perception tells us – and you will all agree – that the perceived age is quite different from the physical age. The older we get the shorter the years seem. If we simply assume that perceived duration is inversely related to physical age and that a 20-year old also perceives a physical year as a psychological one, we come to the surprising discovery that at 90 years we are 90 years old. With an assumed life expectancy of 90 years, 67% (or 82%) of your felt lifetime is behind you at the age of 20 (or 40) physical years. Before we start to wallow in melancholy in the face of the “relativity of time”, let me again quote Augustine. “But at any rate this much I dare affirm I know: that if nothing passed there would be no past time; if nothing were approaching, there would be no future time; if nothing were, there would be no present time.” Well, – or as Bob Dylan sings “The times they are a-changin”. I wish you an exciting time reading this issue. Prof. Martin Wilkens Professor of Quantum Optics T3 - Portal Wissen: The research magazine of the University of Potsdam [Englische Ausgabe] - 02/2014 Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441497 SN - 2198-9974 IS - 02/2014 ER - TY - JOUR A1 - Hafner, Johann Evangelist A1 - Zimmermann, Matthias A1 - Rost, Sophia A1 - Sütterlin, Sabine A1 - Kampe, Heike A1 - Horn-Conrad, Antje A1 - Jäger, Sophie A1 - Eckardt, Barbara A1 - Mangelsdorf, Birgit T1 - Portal Wissen = Believe BT - The Research Magazine of the University of Potsdam N2 - People want to know what is real. Children enjoy listening to a story but when my children were about four years old they started asking whether the story really happened or was just invented. Likewise, only on a higher level, our academic curiosity is fuelled by our interest in knowing what is real. When we analyze poetic texts or dreams we are trying to distinguish between the facts (e.g. neurological ones or linguistic structures) and merely assumed influences. Ideally we can present results that were logically understood by others and that we can repeat empirically. But in most cases this is not possible. We cannot read every book and cannot look through every microscope, not even within our own discipline. In the world we live in we depend on trusting the information of others, like how to get to the train station or what the weather is like in Ulaanbataar. This is why we are used to believing others, our friends or the news anchors. This is not a childish behavior but a necessity. Of course, it is risky because they could all be lying to us, like in a Truman Show situation. The only time we are able to know that we are in reality is when we transcend our selfconsciousness and when we accept two propositions: first, that we are not only objects but also subjects in the consciousness of others and second that our dialogic relations are again observed by a third party that is not part of this intersubjective world. For religious people this is “belief” - belief as the assumption that all human relations only become real, serious and beyond any doubt if they know they are under the eyes of God. Only before Him something is in itself and not only “for me” or “among us”. That is why biblical language distinguishes between three forms of belief: the relationship with the world of things (“to believe that”), the relationship to the world of subjects (“to believe somebody”) and the assumption of a subjective supernatural reality (“to believe in” or “faith”). From an academic point of view belief is a holistic hypothesis. Belief is not the opposite of knowledge but it is the attempt to save reality from doubt by comprehending the fragile empirical world as an expression of a stable transcendent world. When I talk to students they often ask not only about what I know but what I believe. As a professor for Religious Studies and a believing Catholic I am caught in the middle. On the one hand, it is my duty as a professor to doubt everything, i.e. to attribute each religious text to its historical context and sociological functions. On the other hand, I, as a Christian, consider certain religious documents, in my case the Bible, an interpretable but nevertheless irreversible, revealed text about the origin of reality. On weekdays the New Testament is a collection of ancient writings among many others, on Sundays it is the revelation. You can make a clear distinction between these two perspectives but it is difficult to decide whether doubt or belief is more real. This issue of “Portal Wissen” explores this dual relationship of belief. What is the attitude of science towards belief – is it a religious one? Where does science bring things to light that we can hardly believe or that make us believe (again)? What happens if research clears up erroneous assumptions or myths? Is science able to investigate things that are convincing but inexplicable? How can it maintain its credibility and develop even so? These questions appear again and again in the contributions of this “Portal Wissen”. They form a manifold, exciting and surprising picture of the research projects and academics at the University of Potsdam. Believe me, it will be an enjoyable read. Prof. Johann Hafner Professor of Religious Studies with Focus on Christianity Dean of the Faculty of Arts T3 - Portal Wissen: The research magazine of the University of Potsdam [Englische Ausgabe] - 01/2014 Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441461 SN - 2198-9974 IS - 01/2014 ER - TY - JOUR A1 - Sprinz, Detlef F. T1 - Long-term policy problems: definition, origins, and redponses JF - Predicting the Future in Science, Economics, and Politics Y1 - 2014 SN - 978-1-78347-186-7 SP - 126 EP - 143 PB - Elgar CY - Northampton ER - TY - GEN A1 - Kersting, Sebastian A1 - Rausch, Valentina A1 - Bier, Frank Fabian A1 - von Nickisch-Rosenegk, Markus T1 - Multiplex isothermal solid-phase recombinase polymerase amplification for the specific and fast DNA-based detection of three bacterial pathogens T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - We report on the development of an on-chip RPA (recombinase polymerase amplification) with simultaneous multiplex isothermal amplification and detection on a solid surface. The isothermal RPA was applied to amplify specific target sequences from the pathogens Neisseria gonorrhoeae, Salmonella enterica and methicillin-resistant Staphylococcus aureus (MRSA) using genomic DNA. Additionally, a positive plasmid control was established as an internal control. The four targets were amplified simultaneously in a quadruplex reaction. The amplicon is labeled during on-chip RPA by reverse oligonucleotide primers coupled to a fluorophore. Both amplification and spatially resolved signal generation take place on immobilized forward primers bount to expoxy-silanized glass surfaces in a pump-driven hybridization chamber. The combination of microarray technology and sensitive isothermal nucleic acid amplification at 38 °C allows for a multiparameter analysis on a rather small area. The on-chip RPA was characterized in terms of reaction time, sensitivity and inhibitory conditions. A successful enzymatic reaction is completed in <20 min and results in detection limits of 10 colony-forming units for methicillin-resistant Staphylococcus aureus and Salmonella enterica and 100 colony-forming units for Neisseria gonorrhoeae. The results show this method to be useful with respect to point-of-care testing and to enable simplified and miniaturized nucleic acid-based diagnostics. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 730 KW - isothermal amplification KW - RPA KW - microchip KW - DNA sensor KW - point-of-care Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-430479 SN - 1866-8372 IS - 730 SP - 1715 EP - 1723 ER - TY - JOUR A1 - Cramer, Sandra A1 - Tacke, Sebastian A1 - Bornhorst, Julia A1 - Klingauf, Jürgen A1 - Schwerdtle, Tanja A1 - Galla, Hans-Joachim T1 - The Influence of Silver Nanoparticles on the Blood-Brain and the Blood-Cerebrospinal Fluid Barrier in vitro JF - Journal of Nanomedicine & Nanotechnology N2 - The use of silver nanoparticles in medical and consumer products such as wound dressings, clothing and cosmetic has increased significantly in recent years. Still, the influence of these particles on our health and especially on our brain, has not been examined adequately up to now. We studied the influence of AgEO- (Ethylene Oxide) and AgCitrate-Nanoparticles (NPs) on the protective barriers of the brain, namely the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (blood-CSF) barrier in vitro. The NPs toxicity was evaluated by examining changes in membrane integrity, cell morphology, barrier properties, oxidative stress and inflammatory reactions. AgNPs decreased cell viability, disturbed barrier integrity and tight junctions and triggered oxidative stress and DNA strand breaks. However, all mentioned effects were, at least partly, suppressed by a Citrate-coating and were most pronounced in the cells of the BBB as compared to the epithelial cells representing the blood-CSF barrier. AgEO- but not AgCitrate-NPs also triggered an inflammatory reaction in porcine brain capillary endothelial cells (PBCEC), which represent the BBB. Our data indicate that AgNPs may cause adverse effects within the barriers of the brain, but their toxicity can be reduced by choosing an appropriate coating material. Y1 - 2014 U6 - https://doi.org/10.4172/2157-7439.1000225 SN - 2157-7439 VL - 5 IS - 5 ER - TY - JOUR A1 - Noble, Andrew T1 - Ultraschall Berlin BT - Festival für neue Musik, 2014 JF - Tempo: a quarterly review of modern music Y1 - 2014 U6 - https://doi.org/10.1017/S004029821400014X SN - 1478-2286 VL - 68 IS - 269 SP - 76 EP - 78 PB - Cambidge University Press CY - Cambridge ER - TY - GEN A1 - Blankovsky, Yuval T1 - A transgression for the sake of God—‘Averah Li-shmah BT - a tale of a radical idea in Talmudic literature T2 - Postprints der Universität Potsdam : Philosophische Reihe N2 - The Babylonian Talmud (BT) attributes the idea of committing a transgression for the sake of God to R. Nahman b. Isaac (RNBI). RNBI's statement appears in two parallel sugyot in the BT (Nazir 23a; Horayot 10a). Each sugya has four textual witnesses. By comparing these textual witnesses, this paper will attempt to reconstruct the sugya's earlier (or, what some might term, original) dialectical form, from which the two familiar versions of the text in Nazir and Horayot evolved. This article reveals the specific ways in which, value-laden conceptualizations have a major impact on the Talmud's formulation, as we know it today. T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 160 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-416156 SN - 1866-8364 IS - 160 SP - 321 EP - 338 ER - TY - GEN A1 - Noble, Andrew T1 - Ultraschall Berlin BT - Festival für neue Musik, 2014 T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 534 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415117 SN - 1866-8364 IS - 534 SP - 76 EP - 78 ER - TY - GEN A1 - Kaiser, Eurika A1 - Noack, Bernd R. A1 - Cordier, Laurent A1 - Spohn, Andreas A1 - Segond, Marc A1 - Abel, Markus A1 - Daviller, Guillaume A1 - Osth, Jan A1 - Krajnovic, Sinisa A1 - Niven, Robert K. T1 - Cluster-based reduced-order modelling of a mixing layer T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - We propose a novel cluster-based reduced-order modelling (CROM) strategy for unsteady flows. CROM combines the cluster analysis pioneered in Gunzburger's group (Burkardt, Gunzburger & Lee, Comput. Meth. Appl. Mech. Engng, vol. 196, 2006a, pp. 337-355) and transition matrix models introduced in fluid dynamics in Eckhardt's group (Schneider, Eckhardt & Vollmer, Phys. Rev. E, vol. 75, 2007, art. 066313). CROM constitutes a potential alternative to POD models and generalises the Ulam-Galerkin method classically used in dynamical systems to determine a finite-rank approximation of the Perron-Frobenius operator. The proposed strategy processes a time-resolved sequence of flow snapshots in two steps. First, the snapshot data are clustered into a small number of representative states, called centroids, in the state space. These centroids partition the state space in complementary non-overlapping regions (centroidal Voronoi cells). Departing from the standard algorithm, the probabilities of the clusters are determined, and the states are sorted by analysis of the transition matrix. Second, the transitions between the states are dynamically modelled using a Markov process. Physical mechanisms are then distilled by a refined analysis of the Markov process, e. g. using finite-time Lyapunov exponent (FTLE) and entropic methods. This CROM framework is applied to the Lorenz attractor (as illustrative example), to velocity fields of the spatially evolving incompressible mixing layer and the three-dimensional turbulent wake of a bluff body. For these examples, CROM is shown to identify non-trivial quasi-attractors and transition processes in an unsupervised manner. CROM has numerous potential applications for the systematic identification of physical mechanisms of complex dynamics, for comparison of flow evolution models, for the identification of precursors to desirable and undesirable events, and for flow control applications exploiting nonlinear actuation dynamics. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 605 KW - low-dimensional models KW - nonlinear dynamical systems KW - shear layers Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-416113 SN - 1866-8372 IS - 605 SP - 365 EP - 414 ER - TY - GEN A1 - Hoos, Holger A1 - Lindauer, Marius A1 - Schaub, Torsten T1 - claspfolio 2 BT - advances in algorithm selection for answer set programming T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Building on the award-winning, portfolio-based ASP solver claspfolio, we present claspfolio 2, a modular and open solver architecture that integrates several different portfolio-based algorithm selection approaches and techniques. The claspfolio 2 solver framework supports various feature generators, solver selection approaches, solver portfolios, as well as solver-schedule-based pre-solving techniques. The default configuration of claspfolio 2 relies on a light-weight version of the ASP solver clasp to generate static and dynamic instance features. The flexible open design of claspfolio 2 is a distinguishing factor even beyond ASP. As such, it provides a unique framework for comparing and combining existing portfolio-based algorithm selection approaches and techniques in a single, unified framework. Taking advantage of this, we conducted an extensive experimental study to assess the impact of different feature sets, selection approaches and base solver portfolios. In addition to gaining substantial insights into the utility of the various approaches and techniques, we identified a default configuration of claspfolio 2 that achieves substantial performance gains not only over clasp's default configuration and the earlier version of claspfolio, but also over manually tuned configurations of clasp. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 606 KW - solver KW - sat Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-416129 SN - 1866-8372 IS - 606 ER - TY - GEN A1 - Brenten, Thomas A1 - Morris, Penelope J. A1 - Salt, Carina A1 - Raila, Jens A1 - Kohn, Barbara A1 - Brunnberg, Leo A1 - Schweigert, Florian J. A1 - Zentek, Jürgen T1 - Energy intake, growth rate and body composition of young Labrador Retrievers and Miniature Schnauzers fed different dietary levels of vitamin A T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Research in rodents has shown that dietary vitamin A reduces body fat by enhancing fat mobilisation and energy utilisation; however, their effects in growing dogs remain unclear. In the present study, we evaluated the development of body weight and body composition and compared observed energy intake with predicted energy intake in forty-nine puppies from two breeds (twenty-four Labrador Retriever (LAB) and twenty-five Miniature Schnauzer (MS)). A total of four different diets with increasing vitamin A content between 5.24 and 104.80 mu mol retinol (5000-100 000 IU vitamin A)/4184 kJ (1000 kcal) metabolisable energy were fed from the age of 8 weeks up to 52 (MS) and 78 weeks (LAB). The daily energy intake was recorded throughout the experimental period. The body condition score was evaluated weekly using a seven-category system, and food allowances were adjusted to maintain optimal body condition. Body composition was assessed at the age of 26 and 52 weeks for both breeds and at the age of 78 weeks for the LAB breed only using dual-energy X-ray absorptiometry. The growth curves of the dogs followed a breed-specific pattern. However, data on energy intake showed considerable variability between the two breeds as well as when compared with predicted energy intake. In conclusion, the data show that energy intakes of puppies particularly during early growth are highly variable; however, the growth pattern and body composition of the LAB and MS breeds are not affected by the intake of vitamin A at levels up to 104.80 mu mol retinol (100 000 IU vitamin A)/4184 kJ (1000 kcal). T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 603 KW - dog growth KW - vitamin A KW - body composition KW - energy intake Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415681 SN - 1866-8372 IS - 603 ER - TY - GEN A1 - Spahn, Hannah T1 - John Ragosta, Religious Freedom BT - Jefferson's Legacy, America's Creed T2 - Postprints der Universität Potsdam : Philosophische Reihe N2 - kein abstract T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 158 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415362 SN - 1866-8380 IS - 158 SP - 880 EP - 882 ER - TY - GEN A1 - Tu, Rui A1 - Chen, Kejie T1 - Tightly integrated processing of high-rate GPS and accelerometer observations by real-time estimation of transient baseline shifts T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - The complementary advantages of high-rate Global Positioning System (GPS) and accelerometer observations for measuring seismic ground motion have been recognised in previous research. Here we propose an approach of tight integration of GPS and accelerometer measurements. The baseline shifts of the accelerometer are introduced as unknown parameters and estimated by a random walk process in the Precise Point Positioning (PPP) solution. To demonstrate the performance of the new strategy, we carried out several experiments using collocated GPS and accelerometer. The experimental results show that the baseline shifts of the accelerometer are automatically corrected, and high precision coseismic information of strong ground motion can be obtained in real-time. Additionally, the convergence and precision of the PPP is improved by the combined solution. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 598 KW - high-rate GPS KW - accelerometer records KW - baseline shift KW - tight integration KW - Precise Point Positioning Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415182 IS - 598 SP - 869 EP - 881 ER - TY - GEN A1 - Klassert, Annegret A1 - Gagarina, Natalʹja Vladimirovna A1 - Kauschke, Christina T1 - Object and action naming in Russian- and German- speaking monolingual and bilingual children* T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - The present study investigates the influence of word category on naming performance in two populations: bilingual and monolingual children. The question is whether and, if so, to what extent monolingual and bilingual children differ with respect to noun and verb naming and whether a noun bias exists in the lexical abilities of bilingual children. Picture naming of objects and actions by Russian-German bilingual children (aged 4-7 years) was compared to age-matched monolingual children. The results clearly demonstrate a naming deficit of bilingual children in comparison to monolingual children that increases with age. Noun learning is more fragile in bilingual contexts than is verb learning. In bilingual language acquisition, nouns do not predominate over verbs as much as is seen in monolingual German and Russian children. The results are discussed with respect to semantic-conceptual aspects and language-specific features of nouns and verbs, and the impact of input on the acquisition of these word categories. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 531 KW - lexical abilities KW - word categories KW - bilingual children Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415415 SN - 1866-8364 IS - 531 ER - TY - GEN A1 - Dammhahn, Melanie A1 - Goodman, Steven M. T1 - Trophic niche differentiation and microhabitat utilization revealed by stable isotope analyses in a dry-forest bat assemblage at Ankarana, northern Madagascar T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - Bats are important components in tropical mammal assemblages. Unravelling the mechanisms allowing multiple syntopic bat species to coexist can provide insights into community ecology. However, dietary information on component species of these assemblages is often difficult to obtain. Here we measuredstable carbon and nitrogen isotopes in hair samples clipped from the backs of 94 specimens to indirectly examine whether trophic niche differentiation and microhabitat segregation explain the coexistence of 16 bat species at Ankarana, northern Madagascar. The assemblage ranged over 4.4% in delta N-15 and was structured into two trophic levels with phytophagous Pteropodidae as primary consumers (c. 3% enriched over plants) and different insectivorous bats as secondary consumers (c. 4% enriched over primary consumers). Bat species utilizing different microhabitats formed distinct isotopic clusters (metric analyses of delta C-13-delta N-15 bi-plots), but taxa foraging in the same microhabitat did not show more pronounced trophic differentiation than those occupying different microhabitats. As revealed by multivariate analyses, no discernible feeding competition was found in the local assemblage amongst congeneric species as compared with non-congeners. In contrast to ecological niche theory, but in accordance with studies on New and Old World bat assemblages, competitive interactions appear to be relaxed at Ankarana and not a prevailing structuring force. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 595 KW - Ankarana KW - canopy effect KW - Chiroptera KW - coexistence KW - community structure KW - congeneric species KW - dry deciduous forest KW - Madagascar Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415157 SN - 1866-8372 SP - 97 EP - 109 ER - TY - GEN A1 - Clahsen, Harald A1 - Fleischhauer, Elisabeth T1 - Morphological priming in child German T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Regular and irregular inflection in children's production has been examined in many previous studies. Yet, little is known about the processes involved in children's recognition of inflected words. To gain insight into how children process inflected words, the current study examines regular -t and irregular -n participles of German using the cross-modal priming technique testing 108 monolingual German-speaking children in two age groups (group I, mean age: 8;4, group II, mean age: 9;9) and a control group of.. adults. Although both age groups of children had the same full priming effect as adults for -t forms, only children of age group II showed an adult-like (partial) priming effect for -n participles. We argue that children (within the age range tested) employ the same mechanisms for regular inflection as adults but that the lexical retrieval processes required for irregular forms become more efficient when children get older. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 529 KW - inflected words KW - mental lexicon KW - acquisition norms KW - complex words KW - age KW - representation KW - english KW - participles KW - regularity KW - readers Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415491 SN - 1866-8364 IS - 529 SP - 1305 EP - 1333 ER - TY - GEN A1 - Adani, Flavia A1 - Forgiarini, Matteo A1 - Guasti, Maria Teresa A1 - Van der Lely, Heather K. J. T1 - Number dissimilarities facilitate the comprehension of relative clauses in children with (Grammatical) Specific Language Impairment T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - This study investigates whether number dissimilarities on subject and object DPs facilitate the comprehension of subject-and object-extracted centre-embedded relative clauses in children with Grammatical Specific Language Impairment (G-SLI). We compared the performance of a group of English-speaking children with G-SLI (mean age: 12; 11) with that of two groups of younger typically developing (TD) children, matched on grammar and receptive vocabulary, respectively. All groups were more accurate on subject-extracted relative clauses than object-extracted ones and, crucially, they all showed greater accuracy for sentences with dissimilar number features (i.e., one singular, one plural) on the head noun and the embedded DP. These findings are interpreted in the light of current psycholinguistic models of sentence comprehension in TD children and provide further insight into the linguistic nature of G-SLI. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 525 KW - normally developing-children KW - speaking children KW - greek children KW - SLI KW - acquisition KW - english KW - intervention KW - dependencies KW - complexity KW - movement Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415453 SN - 1866-8364 IS - 525 SP - 811 EP - 841 ER - TY - GEN A1 - Höhle, Barbara A1 - Hörnig, Robin A1 - Weskott, Thomas A1 - Knauf, Selene A1 - Krüger, Agnes T1 - Effects of focus and definiteness on children's word order BT - evidence from German five-year-olds' reproductions of double object constructions T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Two experiments tested how faithfully German children aged 4; 5 to 5; 6 reproduce ditransitive sentences that are unmarked or marked with respect to word order and focus (Exp1) or definiteness (Exp2). Adopting an optimality theory (OT) approach, it is assumed that in the German adult grammar word order is ranked lower than focus and definiteness. Faithfulness of children's reproductions decreased as markedness of inputs increased; unmarked structures were reproduced most faithfully and unfaithful outputs had most often an unmarked form. Consistent with the OT proposal, children were more tolerant against inputs marked for word order than for focus; in conflict with the proposal, children were less tolerant against inputs marked for word order than for definiteness. Our results suggest that the linearization of objects in German double object constructions is affected by focus and definiteness, but that prosodic principles may have an impact on the position of a focused constituent. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 511 KW - indefinite articles KW - preschool-children KW - information KW - animacy KW - acquisition KW - constraints KW - sentences KW - language KW - grammar KW - stress Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415695 SN - 1866-8364 IS - 511 ER - TY - GEN A1 - Heyer, Vera A1 - Clahsen, Harald T1 - Late bilinguals see a scan in scanner AND in scandal BT - dissecting formal overlap from morphological priming in the processing of derived words T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Masked priming research with late (non-native) bilinguals has reported facilitation effects following morphologically derived prime words (scanner - scan). However, unlike for native speakers, there are suggestions that purely orthographic prime-target overlap (scandal - scan) also produces priming in non-native visual word recognition. Our study directly compares orthographically related and derived prime-target pairs. While native readers showed morphological but not formal overlap priming, the two prime types yielded the same magnitudes of facilitation for non-natives. We argue that early word recognition processes in a non-native language are more influenced by surface-form properties than in one's native language. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 507 KW - masked priming KW - late bilinguals KW - derivation KW - orthographic overlap Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414441 SN - 1866-8364 IS - 507 ER - TY - GEN A1 - Kienzler, Sarah A1 - Pech, I. A1 - Kreibich, Heidi A1 - Müller, M. A1 - Thieken, Annegret T1 - After the extreme flood in 2002 BT - changes in preparedness, response and recovery of flood-affected residents in Germany between 2005 and 2011 T2 - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe N2 - In the aftermath of the severe flooding in Central Europe in August 2002, a number of changes in flood policies were launched in Germany and other European countries, aiming at improved risk management. The question arises as to whether these changes have already had an impact on the residents' ability to cope with floods, and whether flood-affected private households are now better prepared than they were in 2002. Therefore, computer-aided telephone interviews with private households in Germany that suffered from property damage due to flooding in 2005, 2006, 2010 or 2011 were performed and analysed with respect to flood awareness, precaution, preparedness and recovery. The data were compared to a similar investigation conducted after the flood in 2002. After the flood in 2002, the level of private precautions taken increased considerably. One contributing factor is the fact that, in general, a larger proportion of people knew that they were at risk of flooding. The best level of precaution was found before the flood events in 2006 and 2011. The main reason for this might be that residents had more experience with flooding than residents affected in 2005 or 2010. Yet, overall, flood experience and knowledge did not necessarily result in building retrofitting or flood-proofing measures, which are considered as mitigating damages most effectively. Hence, investments still need to be stimulated in order to reduce future damage more efficiently. Early warning and emergency responses were substantially influenced by flood characteristics. In contrast to flood-affected people in 2006 or 2011, people affected by flooding in 2005 or 2010 had to deal with shorter lead times and therefore had less time to take emergency measures. Yet, the lower level of emergency measures taken also resulted from the people's lack of flood experience and insufficient knowledge of how to protect themselves. Overall, it was noticeable that these residents suffered from higher losses. Therefore, it is important to further improve early warning systems and communication channels, particularly in hilly areas with rapid-onset flooding. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 488 KW - mitigation behavior KW - private households KW - risk perceptions KW - damage KW - motivation KW - people Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-408056 SN - 1866-8372 IS - 488 SP - 505 EP - 526 ER - TY - GEN A1 - Rolinski, Susanne A1 - Rammig, Anja A1 - Walz, Ariane A1 - von Bloh, Werner A1 - van Oijen, M. A1 - Thonicke, Kirsten T1 - A probabilistic risk assessment for the vulnerability of the European carbon cycle to weather extremes BT - The ecosystem perspective T2 - Postprints der Universität Potsdam : Mathematisch naturwissenschaftliche Reihe (487) N2 - Extreme weather events are likely to occur more often under climate change and the resulting effects on ecosystems could lead to a further acceleration of climate change. But not all extreme weather events lead to extreme ecosystem response. Here, we focus on hazardous ecosystem behaviour and identify coinciding weather conditions. We use a simple probabilistic risk assessment based on time series of ecosystem behaviour and climate conditions. Given the risk assessment terminology, vulnerability and risk for the previously defined hazard are estimated on the basis of observed hazardous ecosystem behaviour. We apply this approach to extreme responses of terrestrial ecosystems to drought, defining the hazard as a negative net biome productivity over a 12-month period. We show an application for two selected sites using data for 1981-2010 and then apply the method to the pan-European scale for the same period, based on numerical modelling results (LPJmL for ecosystem behaviour; ERA-Interim data for climate). Our site-specific results demonstrate the applicability of the proposed method, using the SPEI to describe the climate condition. The site in Spain provides an example of vulnerability to drought because the expected value of the SPEI is 0.4 lower for hazardous than for non-hazardous ecosystem behaviour. In northern Germany, on the contrary, the site is not vulnerable to drought because the SPEI expectation values imply wetter conditions in the hazard case than in the non-hazard case. At the pan-European scale, ecosystem vulnerability to drought is calculated in the Mediterranean and temperate region, whereas Scandinavian ecosystems are vulnerable under conditions without water shortages. These first model- based applications indicate the conceptual advantages of the proposed method by focusing on the identification of critical weather conditions for which we observe hazardous ecosystem behaviour in the analysed data set. Application of the method to empirical time series and to future climate would be important next steps to test the approach. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 487 KW - global vegetation model KW - climate extremes KW - fire emissions KW - drought KW - forest KW - productivity KW - reduction KW - events KW - assimilation KW - uncertainty Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-407999 SN - 1866-8372 IS - 487 SP - 1813 EP - 1831 ER - TY - JOUR A1 - Hafer, Jörg A1 - Kiy, Alexander A1 - Lucke, Ulrike T1 - Moodle & Co. auf dem Weg zur Personal Learning Environment JF - eleed N2 - Ausgehend von der typischen IT‐Infrastruktur für E‐Learning an Hochschulen auf der einen Seite sowie vom bisherigen Stand der Forschung zu Personal Learning Environments (PLEs) auf der anderen Seite zeigt dieser Beitrag auf, wie bestehende Werkzeuge bzw. Dienste zusammengeführt und für die Anforderungen der modernen, rechnergestützten Präsenzlehre aufbereitet werden können. Für diesen interdisziplinären Entwicklungsprozess bieten sowohl klassische Softwareentwicklungsverfahren als auch bestehende PLE‐Modelle wenig Hilfestellung an. Der Beitrag beschreibt die in einem campusweiten Projekt an der Universität Potsdam verfolgten Ansätze und die damit erzielten Ergebnisse. Dafür werden zunächst typische Lehr‐/Lern‐bzw. Kommunikations‐Szenarien identifiziert, aus denen Anforderungen an eine unterstützende Plattform abgeleitet werden. Dies führt zu einer umfassenden Sammlung zu berücksichtigender Dienste und deren Funktionen, die gemäß den Spezifika ihrer Nutzung in ein Gesamtsystem zu integrieren sind. Auf dieser Basis werden grundsätzliche Integrationsansätze und technische Details dieses Mash‐Ups in einer Gesamtschau aller relevanten Dienste betrachtet und in eine integrierende Systemarchitektur überführt. Deren konkrete Realisierung mit Hilfe der Portal‐Technologie Liferay wird dargestellt, wobei die eingangs definierten Szenarien aufgegriffen und exemplarisch vorgestellt werden. Ergänzende Anpassungen im Sinne einer personalisierbaren bzw. adaptiven Lern‐(und Arbeits‐)Umgebung werden ebenfalls unterstützt und kurz aufgezeigt. Y1 - 2014 UR - https://eleed.campussource.de/archive/10/4085 SN - 1860-7470 VL - 2014 IS - 10 ER - TY - CHAP A1 - Kiy, Alexander A1 - Lucke, Ulrike ED - Rensing, C. ED - Trahasch, S. T1 - Learning analytic tools in practical comparison T2 - DeLFI Workshops of the 12th e-Learning Conference of the German Computer Society, DeLFI 2014; Freiburg; Germany; 15 September 2014 through 15 September 2014 CEUR Workshop Proceedings T2 - Learning-analytics-werkzeuge im praxisvergleich Y1 - 2014 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84921854348&partnerID=MN8TOARS SN - 1613-0073 VL - 2014 IS - 1227 SP - 104 EP - 111 PB - Technical University of Aachen CY - Aachen ER - TY - CHAP A1 - Kiy, Alexander A1 - Lucke, Ulrike A1 - Zoerner, Dietmar T1 - An adaptive personal learning environment architecture T2 - Architecture of Computing Systems – ARCS 2014 Lecture Notes in Computer Science N2 - Institutions are facing the challenge to integrate legacy systems with steadily growing new ones, using different technologies and interaction patterns. With the demand of offering the best potential of all systems, several not matching systems including their functions have to be aggregated and offered in a useable way. This paper presents an adaptive, generalizable and self-organized Personal Learning Environment (PLE) framework with the potential to integrate several heterogeneous services using a service-oriented architecture. First, a general overview over the field is given, followed by the description of the core components of the PLE framework. A prototypical implementation is presented. Finally, it’s shown how the PLE framework can be dynamically adapted to a changing system environment, reflecting experiences from first user studies. KW - Service-oriented architecture KW - Personal Learning Environment KW - University Service Bus Y1 - 2014 SN - 978-3-319-04890-1 VL - 2014 IS - 8350 SP - 60 EP - 71 PB - Springer ER - TY - CHAP A1 - Knoth, Alexander Henning A1 - Kiy, Alexander T1 - (Self-)confident through the introductory study phase with the Reflect App BT - (Self-)confident through the introductory study phase with the Reflect App T2 - CEUR Workshop Proceedings T2 - Selbst-bewusst durch die Studieneingangsphase mit der Reflect-App Y1 - 2014 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84921875162&partnerID=MN8TOARS SN - 1613-0073 IS - 1227 SP - 172 EP - 179 PB - CEUR-WS CY - Freiburg ER - TY - JOUR A1 - Günther, Oliver T1 - Big Data: What is it? And what does it mean for science, economy and society? JF - Informatik-Spektrum Y1 - 2014 UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84897396415&partnerID=MN8TOARS U6 - https://doi.org/10.1007/s00287-014-0783-7 SN - 0170-6012 VL - 37 IS - 2 SP - 85 EP - 86 PB - Springer Verlag CY - Heidelberg ER - TY - GEN A1 - Cao, Xianyong A1 - Herzschuh, Ulrike A1 - Ni, Jian A1 - Zhao, Yan A1 - Böhmer, Thomas T1 - Spatial and temporal distributions of major tree taxa in eastern continental Asia during the last 22,000 years T2 - The Holocene N2 - This study investigates the spatial and temporal distributions of 14 key arboreal taxa and their driving forces during the last 22,000 calendar years before ad 1950 (kyr BP) using a taxonomically harmonized and temporally standardized fossil pollen dataset with a 500-year resolution from the eastern part of continental Asia. Logistic regression was used to estimate pollen abundance thresholds for vegetation occurrence (presence or dominance), based on modern pollen data and present ranges of 14 taxa in China. Our investigation reveals marked changes in spatial and temporal distributions of the major arboreal taxa. The thermophilous (Castanea, Castanopsis, Cyclobalanopsis, Fagus, Pterocarya) and eurythermal (Juglans, Quercus, Tilia, Ulmus) broadleaved tree taxa were restricted to the current tropical or subtropical areas of China during the Last Glacial Maximum (LGM) and spread northward since c. 14.5 kyr BP. Betula and conifer taxa (Abies, Picea, Pinus), in contrast, retained a wider distribution during the LGM and showed no distinct expansion direction during the Late Glacial. Since the late mid-Holocene, the abundance but not the spatial extent of most trees decreased. The changes in spatial and temporal distributions for the 14 taxa are a reflection of climate changes, in particular monsoonal moisture, and, in the late Holocene, human impact. The post-LGM expansion patterns in eastern continental China seem to be different from those reported for Europe and North America, for example, the westward spread for eurythermal broadleaved taxa. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 417 KW - China KW - Holocene KW - Last Glacial Maximum KW - pollen mapping KW - vegetation expansion Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404176 VL - 25 IS - 1 ER - TY - GEN A1 - Scheller, Henrik T1 - Ed Turner, political parties and public policy in the German Länder BT - when parties matter T2 - Party politics N2 - kein abstract vorhanden T3 - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 89 Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404163 ER - TY - GEN A1 - Reiterer, Susanne Maria A1 - Festman, Julia T1 - Special issue: multilingual brains BT - individual differences in bi-and multilinguals T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - keine abstracts vorhanden T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 393 Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404188 IS - 393 ER - TY - GEN A1 - Tian, Fang A1 - Herzschuh, Ulrike A1 - Mischke, Steffen A1 - Schlütz, Frank T1 - What drives the recent intensified vegetation degradation in Mongolia BT - Climate change or human activity? T2 - The Holocene N2 - This study examines the course and driving forces of recent vegetation change in the Mongolian steppe. A sediment core covering the last 55years from a small closed-basin lake in central Mongolia was analyzed for its multi-proxy record at annual resolution. Pollen analysis shows that highest abundances of planted Poaceae and highest vegetation diversity occurred during 1977-1992, reflecting agricultural development in the lake area. A decrease in diversity and an increase in Artemisia abundance after 1992 indicate enhanced vegetation degradation in recent times, most probably because of overgrazing and farmland abandonment. Human impact is the main factor for the vegetation degradation within the past decades as revealed by a series of redundancy analyses, while climate change and soil erosion play subordinate roles. High Pediastrum (a green algae) influx, high atomic total organic carbon/total nitrogen (TOC/TN) ratios, abundant coarse detrital grains, and the decrease of C-13(org) and N-15 since about 1977 but particularly after 1992 indicate that abundant terrestrial organic matter and nutrients were transported into the lake and caused lake eutrophication, presumably because of intensified land use. Thus, we infer that the transition to a market economy in Mongolia since the early 1990s not only caused dramatic vegetation degradation but also affected the lake ecosystem through anthropogenic changes in the catchment area. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 418 KW - central Mongolia KW - grain size KW - human impact KW - lake eutrophication KW - pollen KW - vegetation degradation Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404201 ER - TY - GEN A1 - Bondü, Rebecca A1 - Beier, Sophia T1 - Two of a kind? BT - differences and similarities of attacks in schools and in institutes of higher education T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - School attacks are attracting increasing attention in aggression research. Recent systematic analyses provided new insights into offense and offender characteristics. Less is known about attacks in institutes of higher education (e.g., universities). It is therefore questionable whether the term “school attack” should be limited to institutions of general education or could be extended to institutions of higher education. Scientific literature is divided in distinguishing or unifying these two groups and reports similarities as well as differences. We researched 232 school attacks and 45 attacks in institutes of higher education throughout the world and conducted systematic comparisons between the two groups. The analyses yielded differences in offender (e.g., age, migration background) and offense characteristics (e.g., weapons, suicide rates), and some similarities (e.g., gender). Most differences can apparently be accounted for by offenders’ age and situational influences. We discuss the implications of our findings for future research and the development of preventative measures. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 391 KW - school attack KW - IHE attack KW - rampage KW - higher education KW - characteristics KW - prevention Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404199 IS - 391 ER - TY - GEN A1 - Bondü, Rebecca A1 - Scheithauer, Herbert T1 - Leaking and death-threats by students BT - a study in German schools T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Leaking comprises observable behavior or statements that signal intentions of committing a violent offense and is considered an important warning sign for school shootings. School staff who are confronted with leaking have to assess its seriousness and react appropriately - a difficult task, because knowledge about leaking is sparse. The present study, therefore, examined how frequently leaking occurs in schools and how teachers identify leaking and respond to it. To achieve this aim, we informed teachers from eight schools in Germany about the definition of leaking and other warning signs and risk factors for school shootings in a one-hour information session. Teachers were then asked to report cases of leaking over a six- to nine-month period and to answer a questionnaire on leaking and its treatment after the information session and six to nine months later. Our results suggest that leaking is a relevant problem in German schools. Teachers mostly rated the information session positively and benefited in several aspects (e.g. reported more perceived courses of action or improved knowledge about leaking), but also expressed a constant need for support. Our findings highlight teachers' needs for further support and training and may be used in the planning of prevention measures for school shootings. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 388 KW - death-threats KW - leaking KW - prevention KW - school shooting KW - violence in schools Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404121 IS - 388 ER - TY - GEN A1 - Hustedt, Thurid A1 - Salomonsen, Heidi Houlberg T1 - Ensuring political responsiveness BT - politicization mechanisms in ministerial bureaucracies T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Although politicization is a perennial research topic in public administration to investigate relationships between ministers and civil servants, the concept still lacks clarification. This article contributes to this literature by systematically identifying different conceptualizations of politicization and suggests a typology including three politicization mechanisms to strengthen the political responsiveness of the ministerial bureaucracy: formal, functional and administrative politicization. The typology is empirically validated through a comparative case analysis of politicization mechanisms in Germany, Belgium, the UK and Denmark. The empirical analysis further refines the general idea of Western democracies becoming ‘simply’ more politicized, by illustrating how some politicization mechanisms do not continue to increase, but stabilize – at least for the time being. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 387 KW - central administration KW - ministers and civil servants KW - political advisers KW - political responsiveness KW - politicization KW - public administration Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404117 IS - 387 ER - TY - GEN A1 - Völler, Heinz A1 - Salzwedel, Annett A1 - Nitardy, Aischa A1 - Buhlert, Hermann A1 - Treszl, Andra ́s A1 - Wegscheider, Karl T1 - Effect of cardiac rehabilitation on functional and emotional status in patients after transcatheter aortic-valve implantation T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background Transcatheter aortic-valve implantation (TAVI) is an established alternative therapy in patients with severe aortic stenosis and a high surgical risk. Despite a rapid growth in its use, very few data exist about the efficacy of cardiac rehabilitation (CR) in these patients. We assessed the hypothesis that patients after TAVI benefit from CR, compared to patients after surgical aortic-valve replacement (sAVR). Methods From September 2009 to August 2011, 442 consecutive patients after TAVI (n=76) or sAVR (n=366) were referred to a 3-week CR. Data regarding patient characteristics as well as changes of functional (6-min walk test. 6-MWT), bicycle exercise test), and emotional status (Hospital Anxiety and Depression Scale) were retrospectively evaluated and compared between groups after propensity score adjustment. Results Patients after TAVI were significantly older (p<0.001), more female (p<0.001), and had more often coronary artery disease (p=0.027), renal failure (p=0.012) and a pacemaker (p=0.032). During CR, distance in 6-MWT (both groups p0.001) and exercise capacity (sAVR p0.001, TAVI p0.05) significantly increased in both groups. Only patients after sAVR demonstrated a significant reduction in anxiety and depression (p0.001). After propensity scores adjustment, changes were not significantly different between sAVR and TAVI, with the exception of 6-MWT (p=0.004). Conclusions Patients after TAVI benefit from cardiac rehabilitation despite their older age and comorbidities. CR is a helpful tool to maintain independency for daily life activities and participation in socio-cultural life. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 385 KW - Cardiac rehabilitation KW - emotional status KW - functional capacity KW - surgical aortic valve replacement (sAVR) KW - transcatheter aortic valve implantation (TAVI) Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404100 IS - 385 ER - TY - GEN A1 - Völler, Heinz A1 - Gitt, Anselm A1 - Jannowitz, Christina A1 - Karoff, Marthin A1 - Karmann, Barbara A1 - Pittrow, David A1 - Reibis, Rona Katharina A1 - Hildemann, Steven T1 - Treatment patterns, risk factor control and functional capacity in patients with cardiovascular and chronic kidney disease in the cardiac rehabilitation setting T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Background: Chronic kidney disease (CKD) is a frequent comorbidity among elderly patients and those with cardiovascular disease. CKD carries prognostic relevance. We aimed to describe patient characteristics, risk factor management and control status of patients in cardiac rehabilitation (CR), differentiated by presence or absence of CKD. Design and methods: Data from 92,071 inpatients with adequate information to calculate glomerular filtration rate (GFR) based on the Cockcroft-Gault formula were analyzed at the beginning and the end of a 3-week CR stay. CKD was defined as estimated GFR <60 ml/min/1.73 m(2). Results: Compared with non-CKD patients, CKD patients were significantly older (72.0 versus 58.0 years) and more often had diabetes mellitus, arterial hypertension, and atherothrombotic manifestations (previous stroke, peripheral arterial disease), but fewer were current or previous smokers had a CHD family history. Exercise capacity was much lower in CKD (59 vs. 92Watts). Fewer patients with CKD were treated with percutaneous coronary intervention (PCI), but more had coronary artery bypass graft (CABG) surgery. Patients with CKD compared with non-CKD less frequently received statins, acetylsalicylic acid (ASA), clopidogrel, beta blockers, and angiotensin converting enzyme (ACE) inhibitors, and more frequently received angiotensin receptor blockers, insulin and oral anticoagulants. In CKD, mean low density lipoprotein cholesterol (LDL-C), total cholesterol, and high density lipoprotein cholesterol (HDL-C) were slightly higher at baseline, while triglycerides were substantially lower. This lipid pattern did not change at the discharge visit, but overall control rates for all described parameters (with the exception of HDL-C) were improved substantially. At discharge, systolic blood pressure (BP) was higher in CKD (124 versus 121 mmHg) and diastolic BP was lower (72 versus 74 mmHg). At discharge, 68.7% of CKD versus 71.9% of non-CKD patients had LDL-C <100 mg/dl. Physical fitness on exercise testing improved substantially in both groups. When the Modification of Diet in Renal Disease (MDRD) formula was used for CKD classification, there was no clinically relevant change in these results. Conclusion: Within a short period of 3-4 weeks, CR led to substantial improvements in key risk factors such as lipid profile, blood pressure, and physical fitness for all patients, even if CKD was present. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 381 KW - Cardiac rehabilitation KW - registry KW - chronic kidney disease KW - glomerular filtration rate KW - dyslipidemia KW - control rates KW - risk factor KW - lipids Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-404065 IS - 381 ER - TY - THES A1 - Hermawan, Romy T1 - Coordination and civil service reform in Indonesia (1999-2009) N2 - The background of civil service reform in Indonesia reveals the emergence of the reformation movement in 1998, following the fall of the authoritarian New Order regime. The reformation movement has seen the introduction of reforms in Indonesia's various governmental institutions, including the civil service. The civil service reforms were marked by the revision of Act 8/ 74 with Act 43 of 1999 on Civil Service Administration. The implementation of the civil service reform program, which was carried out by both central and local governments, required cooperation between the actors (in particular, Ministries, agencies and local governments), known as coordination. Currently, the coordination that occurs between actors tends to be rigid and hierarchical. As a result, targets are not efficiently and effectively met. Hierarchical coordination, without a strong public sector infrastructure, tends to have a negative impact on achieving the desired outcomes of the civil service reform program. As an intrinsic part of the New Order regime, hierarchical coordination resulted in inefficiency and lack of efficacy. Despite these inefficiencies, the administration and the political environment have changed significantly as a result of the reform process. Obvious examples of the reforms are changes in recruitment patterns, placement and remuneration policies. However, in the case of Indonesia, it appears that every state institution has its own policy. Thus, it appears that there has not been policy coherence in the civil service reform program, resulting in the lack of a sustainable program. The important thing to examine is how the coordination mechanisms of the civil service reform program in the central government have developed during the reform era in Indonesia The purpose of this study is to analyse the linkages between coordination mechanisms and the actual implementation of civil service reform programs. This is undertaken as a basis for intervention based on the structures and patterns of coordination mechanisms in the implementation of civil service reform programs. The next step is to formulate the development coordination mechanisms, particularly to create structures and patterns of civil service reforms which are more sustainable to the specific characteristics of public sector organisations in Indonesia. The benefits of this research are a stronger understanding of the linkages between the mechanisms of coordination and implementation of civil service reform programs. Through this analysis, the findings can then be applied as a basic consideration in planning a sustainable civil service reform program. In the basis of theoretical issues concerning the linkages between coordination mechanisms and implementation of civil service reform program sustainability, this book explores the type of coordination, which is needed to test the proportional and sustainable concept of the intended civil service reform program in Indonesia. Research conducted through studies, surveys and donors has shown that poor coordination is the major hindrance to the civil service program reform in Indonesia. This research employs a qualitative approach. In this study, the coordination mechanisms and implementations of civil service reform programs are demonstrated by means of case studies of the State Ministry for Administrative Reform, the National Civil Service Agency and the National Public Administration Institute. The coordination mechanisms in these Ministries and agencies were analysed using indicators of effective and efficient coordination. The analysis of the coordination mechanisms shows a tendency towards rigid hierarchical coordination. This raises concerns about fragmentation among departments and agencies at the central government level and calls for integrated civil service reform both at central and local governmental levels. In the context of implementation programs, a hierarchical mechanism of coordination leverages on various aspects, such as the program formulation, implementation flow of the program, the impact of policies, and achievement targets. In particular, there was a shift process of the mainstream civil service reform in the Ministries and agencies which are marked by the emergence of sectoral interest and inefficiencies in the civil service reform program. The primary result of successful civil service reform is increased professionalism in the civil service. The findings on hierarchical mechanisms and the prescriptions which will follow show that the professionalism of Indonesia’s civil service is at stake. The implementation of the program through coordination mechanisms in Ministries and agencies is measured in various dimensions: the centre of coordination, integration of coordination, sustainability of coordination and multidimensionality of coordination. The results of this analysis show that coordination mechanisms and the implementation of civil service reform are more successful when they are integration rather than hierarchical mechanisms. For a successful implementation of the reform program, it is crucial to intervene and change the type of coordination at the central government through the integration approach (hierarchy, market, and network). Furthermore, in order to move towards the integration type mechanism of coordination the separation of the administration and politics in the practice of good governance needs to be carried out immediately and simultaneously. Based on this analysis, it can be concluded that the integration type mechanism of coordination is a suitable for Indonesia for a sustainable civil service reform program. Finally, to achieve coherent civil service reforms, national policies developed according to the central government's priorities are indispensable, establishing a coordination mechanism that can be adhered to throughout all reform sectors. N2 - Seit dem Sturz des autoritären und dem Wechsel zum Regime des „New Order“ im Jahre 1998 haben die Reformbemühungen in der öffentlichen Verwaltung in Indonesien stark zugenommen. Ihren Ursprung nahmen sie mit der Revision des Gesetzes 8/74 und 43 im Jahre 1999 betreffend die Grundlagen der öffentlichen Verwaltung. Implementiert wurde die Reform sowohl durch die Zentralregierung als auch durch die Lokalregierungen. Jedoch erforderte die Implementierung dieses Programmes auch die Zusammenarbeit bzw. die Koordination verschiedener Akteure, wie beispielsweise Ministerien, Behörden, und Lokalregierungen. Die gegenwärtige Koordination zwischen diesen Akteuren ist rigide und hierarchisch. Daraus ergibt sich, dass die gesteckten Ziele nicht effizient und effektiv erreicht werden. Hierarchische Koordination ohne eine gefestigte Verwaltungsstruktur verhindert die Umsetzung des Reformprogrammes. Als intrinsisches Merkmal des „New Order“ Regimes führt die hierarchische Koordination zur Ineffizienz und einem Mangel an Effektivität. Trotz dieser Ineffizienzen haben die Reformen zu signifikanten Veränderungen in der Verwaltung und im politischen Umfeld geführt. Offensichtliche Beispiele der Verwaltungsreform sind Änderungen in der Einstellungs-, Beförderungs- und Entlohnungspraxis. Im Falle Indonesiens jedoch scheint jede einzelne Institution ihr eigenes Regelwerk zu besitzen. Dies deutet darauf hin, dass das Verwaltungsreformprogramm keine allzu große Kohärenz aufgewiesen hat. Es ist hierbei wichtig zu untersuchen wie die Koordinationsmechanismen dieses Programmes sich nach der Reformära in Indonesien entwickelt haben. Diese Studie hat die Absicht, die Verbindungen zwischen den Koordinationsmechanismen und den tatsächlichen Durchführung des Reformprogrammes der öffentlichen Verwaltung zu analysieren. Offensichtlich zeichnete sich dieseweder durch Kohärenz noch eine nachhaltige Implementierung aus. Es ist nun wichtig, eine Richtung zu bestimmen, wie die Koordinationsmechanismen sich entwickeln müssten um Strukturen und Mechanismen zu schaffen, die besser zu den spezifischen Charakteristiken der öffentlichen Verwaltungen in Indonesien passen. Diese Untersuchung trägt dazu bei, die Zusammenhänge zwischen Koordinationsmechanismen und des tatsächlichen Implementationserfolges von Reformprogrammen der öffentlichen Verwaltung zu verstehen. Ein solches Analyseergebnis kann dann zu nachhaltigen Reformbemühungen beitragen. Ausgehend von theoretischen Überlegungen bezüglich der Verbindung von Koordinationsmechanismen und der Implementierung von Reformprogrammen der öffentlichen Verwaltung, erforscht diese Studie verschiedene Aspekte des Koordinationstypus, der notwendig scheint, um das verhältnismäßige und nachhaltigeKonzept des beabsichtigten Reformprogrammes in Indonesien zu testen. Bisherige Forschung auf dem Gebiet der Koordination zeigt, dass das größte Hindernis für ein erfolgreiches Reformprogramm der öffentlichen Verwaltung ein Mangel an Koordination ist. Diese Studie wählt einen qualitativen Ansatz. Sie zeigt die Koordinationsmechanismen bei der Implementation von Reformprogrammen in der öffentlichen Verwaltung an den Fallbeispielen des „Staatsministeriums für Administrative Reformen“, der „Nationalen Agentur für den Öffentlichen Dienst“ und des „Nationalen Instituts für die Öffentliche Verwaltung“. Die Koordinationsmechanismen dieser Ministerien und Institute wurden dabei auf Grundlage von Indikatoren für effektive und effiziente Koordination untersucht. Die Analyse zeit tendenziell, dass die Koordination einerigide und hierarchische Form annimmt. Dies lässt Bedenken über die Fragmentierung der Abteilungen und Agenturen der Zentralregierung aufkommen und verdeutlicht die Notwendigkeit einer integrierten Reform der öffentlichen Verwaltung sowohl auf der Ebene der Zentralregierung als auch der Lokalregierungen. Im Kontext der Implementierungsbemühungen berührt eine hierarchische Koordination verschiedene Aspekte wie zum Beispiel die Formulierung des Programmes, der Ablauf der Implementation, der Einfluss des Regelwerks und die Erreichung der gesteckten Ziele. Insbesondere konnte beobachtet werden, dass sich der grundlegende Verwaltungsprozesses in den Ministerien und den Agenturen verlagert hat, was sich durch die Verstärkung sektoraler Interessen und zunehmender Ineffizienzen des Reformprogrammes ausdrückt. Das derzeitige Ergebnis ist im Wesentlichen eine zunehmende Professionalisierung des öffentlichen Dienstes. Die Befunde über hierarchische Mechanismen und die danach folgenden Vorgaben stellen die Professionalität des öffentlichen Dienstes in Indonesien in Frage. Die Implementierung des Reformprogrammes durch Koordinationsmechanismen in Ministerien und Agenturen werden auf mehreren Dimensionen gemessen: der Ausgangspunkt der Koordination, ihre Einbindung, Nachhaltigkeit und Mehrdimensionalität. Die Ergebnisse dieser Analyse zeigen, dass integrative Koordinationsmechanismen und Implementationen erfolgreicher sind als hierarchische. Um das restliche Reformprogramm erfolgreich zu einem Ende zu bringen, erscheint es wesentlich einzugreifen und die vorherrschende Koordination in der Zentralregierung durch einen integrativen Ansatz zu ersetzen (Hierarchie, Markt, Netzwerk). Darüber hinaus muss, um dies zu erreichen, die Trennung von Verwaltung und Politik im Sinne der guten Regierungsführung gleichzeitig umgesetzt werden. Auf Grundlage dieser Analyse kann gefolgert werden, dass der integrative Ansatz bei der Koordination geeignet erscheint, um das Reformprogramm der öffentlichen Verwaltung in Indonesien umzusetzen. Schlussendlich, um eine einheitliche Reform der öffentlichen Verwaltung zu erreichen bedarf es einer zentralen Koordinationsstrategie der Zentralregierung, die einheitlich in allen Reformsektoren befolgt wird. KW - Indonesien KW - Verwaltungsreform KW - Geschichte 1999-2009 KW - Coordination KW - Civil Service Reform KW - Bureaucracy Y1 - 2014 SN - 978-602-284-061-9 PB - Center of South South Cooperation Studies, Univ. CY - Brawijaya ER - TY - GEN A1 - Brand, Ralf A1 - Wolff, Wanja A1 - Thieme, Detlef T1 - Using response-time latencies to measure athletes’ doping attitudes BT - the brief implicit attitude test identifies substance abuse in bodybuilders N2 - Background: Knowing and, if necessary, altering competitive athletes' real attitudes towards the use of banned performance-enhancing substances is an important goal of worldwide doping prevention efforts. However athletes will not always be willing to reporting their real opinions. Reaction time-based attitude tests help conceal the ultimate goal of measurement from the participant and impede strategic answering. This study investigated how well a reaction time-based attitude test discriminated between athletes who were doping and those who were not. We investigated whether athletes whose urine samples were positive for at least one banned substance (dopers) evaluated doping more favorably than clean athletes (non-dopers). Methods: We approached a group of 61 male competitive bodybuilders and collected urine samples for biochemical testing. The pictorial doping Brief Implicit Association Test (BIAT) was used for attitude measurement. This test quantifies the difference in response latencies (in milliseconds) to stimuli representing related concepts (i.e. doping-dislike/like-[health food]). Results: Prohibited substances were found in 43% of all tested urine samples. Dopers had more lenient attitudes to doping than non-dopers (Hedges's g = -0.76). D-scores greater than -0.57 (CI95 = -0.72 to -0.46) might be indicative of a rather lenient attitude to doping. In urine samples evidence of administration of combinations of substances, complementary administration of substances to treat side effects and use of stimulants to promote loss of body fat was common. Conclusion: This study demonstrates that athletes' attitudes to doping can be assessed indirectly with a reaction time-based test, and that their attitudes are related to their behavior. Although bodybuilders may be more willing to reveal their attitude to doping than other athletes, these results still provide evidence that the pictorial doping BIAT may be useful in athletes from other sports, perhaps as a complementary measure in evaluations of the effectiveness of doping prevention interventions. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 361 KW - steroid use KW - psychology KW - doping tests KW - biochemical profiles Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-401430 ER - TY - GEN A1 - Schedina, Ina Maria A1 - Hartmann, Stefanie A1 - Groth, Detlef A1 - Schlupp, Ingo A1 - Tiedemann, Ralph T1 - Comparative analysis of the gonadal transcriptomes of the all-female species Poecilia formosa and its maternal ancestor Poecilia mexicana N2 - Background The Amazon molly, Poecilia formosa (Teleostei: Poeciliinae) is an unisexual, all-female species. It evolved through the hybridisation of two closely related sexual species and exhibits clonal reproduction by sperm dependent parthenogenesis (or gynogenesis) where the sperm of a parental species is only used to activate embryogenesis of the apomictic, diploid eggs but does not contribute genetic material to the offspring. Here we provide and describe the first de novo assembled transcriptome of the Amazon molly in comparison with its maternal ancestor, the Atlantic molly Poecilia mexicana. The transcriptome data were produced through sequencing of single end libraries (100 bp) with the Illumina sequencing technique. Results 83,504,382 reads for the Amazon molly and 81,625,840 for the Atlantic molly were assembled into 127,283 and 78,961 contigs for the Amazon molly and the Atlantic molly, respectively. 63% resp. 57% of the contigs could be annotated with gene ontology terms after sequence similarity comparisons. Furthermore, we were able to identify genes normally involved in reproduction and especially in meiosis also in the transcriptome dataset of the apomictic reproducing Amazon molly. Conclusions We assembled and annotated the transcriptome of a non-model organism, the Amazon molly, without a reference genome (de novo). The obtained dataset is a fundamental resource for future research in functional and expression analysis. Also, the presence of 30 meiosis-specific genes within a species where no meiosis is known to take place is remarkable and raises new questions for future research. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 404 Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-401420 ER - TY - GEN A1 - Golle, Kathleen A1 - Granacher, Urs A1 - Hoffmann, Martin A1 - Wick, Ditmar A1 - Mühlbauer, Thomas T1 - Effect of living area and sports club participation on physical fitness in children BT - a 4 year longitudinal study N2 - Background: Cross-sectional studies detected associations between physical fitness, living area, and sports participation in children. Yet, their scientific value is limited because the identification of cause-and-effect relationships is not possible. In a longitudinal approach, we examined the effects of living area and sports club participation on physical fitness development in primary school children from classes 3 to 6. Methods: One-hundred and seventy-two children (age: 9-12 years; sex: 69 girls, 103 boys) were tested for their physical fitness (i.e., endurance [9-min run], speed [50-m sprint], lower- [triple hop] and upper-extremity muscle strength [1-kg ball push], flexibility [stand-and-reach], and coordination [star coordination run]). Living area (i.e., urban or rural) and sports club participation were assessed using parent questionnaire. Results: Over the 4 year study period, urban compared to rural children showed significantly better performance development for upper- (p = 0.009, ES = 0.16) and lower-extremity strength (p < 0.001, ES = 0.22). Further, significantly better performance development were found for endurance (p = 0.08, ES = 0.19) and lower-extremity strength (p = 0.024, ES = 0.23) for children continuously participating in sports clubs compared to their non-participating peers. Conclusions: Our findings suggest that sport club programs with appealing arrangements appear to represent a good means to promote physical fitness in children living in rural areas. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 360 KW - motor performance KW - youth KW - primary school KW - maturation Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-401418 ER - TY - GEN A1 - Brand, Ralf A1 - Heck, Philipp A1 - Ziegler, Matthias T1 - Illegal performance enhancing drugs and doping in sport BT - a picture-based brief implicit association test for measuring athletes' attitudes N2 - Background: Doping attitude is a key variable in predicting athletes' intention to use forbidden performance enhancing drugs. Indirect reaction-time based attitude tests, such as the implicit association test, conceal the ultimate goal of measurement from the participant better than questionnaires. Indirect tests are especially useful when socially sensitive constructs such as attitudes towards doping need to be described. The present study serves the development and validation of a novel picture-based brief implicit association test (BIAT) for testing athletes' attitudes towards doping in sport. It shall provide the basis for a transnationally compatible research instrument able to harmonize anti-doping research efforts. Method: Following a known-group differences validation strategy, the doping attitudes of 43 athletes from bodybuilding (representative for a highly doping prone sport) and handball (as a contrast group) were compared using the picture-based doping-BIAT. The Performance Enhancement Attitude Scale (PEAS) was employed as a corresponding direct measure in order to additionally validate the results. Results: As expected, in the group of bodybuilders, indirectly measured doping attitudes as tested with the picture-based doping-BIAT were significantly less negative (eta(2) = .11). The doping-BIAT and PEAS scores correlated significantly at r = .50 for bodybuilders, and not significantly at r = .36 for handball players. There was a low error rate (7%) and a satisfactory internal consistency (r(dagger dagger) = .66) for the picture-based doping-BIAT. Conclusions: The picture-based doping-BIAT constitutes a psychometrically tested method, ready to be adopted by the international research community. The test can be administered via the internet. All test material is available "open source". The test might be implemented, for example, as a new effect-measure in the evaluation of prevention programs. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 359 KW - doping attitude KW - bodybuilding KW - indirect test KW - implicit attitude test (IAT) KW - methodology Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-401404 ER - TY - GEN A1 - Noiray, Aude A1 - Iskarous, Khalil A1 - Whalen, Douglas H. T1 - Variability in English vowels is comparable in articulation and acoustics T2 - Postprints der Universität Potsdam : Philosophische Reihe N2 - The nature of the links between speech production and perception has been the subject of longstanding debate. The present study investigated the articulatory parameter of tongue height and the acoustic F1–F0 difference for the phonological distinction of vowel height in American English front vowels. Multiple repetitions of /i, ɪ, e, ɛ, æ/ in [(h)Vd] sequences were recorded in seven adult speakers. Articulatory (ultrasound) and acoustic data were collected simultaneously to provide a direct comparison of variability in vowel production in both domains. Results showed idiosyncratic patterns of articulation for contrasting the three front vowel pairs /i-ɪ/, /e-ɛ/, and /ɛ-æ/ across subjects, with the degree of variability in vowel articulation comparable to that observed in the acoustics for all seven participants. However, contrary to what was expected, some speakers showed reversals for tongue height for /ɪ/-/e/ that were also reflected in acoustics, with F1 higher for /ɪ/ than for /e/. The data suggest the phonological distinction of height is conveyed via speaker-specific articulatory-acoustic patterns that do not strictly match features descriptions. However, the acoustic signal is faithful to the articulatory configuration that generated it, carrying the crucial information for perceptual contrast. T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 137 KW - Speech motor control KW - American-english KW - Normalization procedures KW - Regional varieties KW - Movements KW - Dynamics KW - Behavior KW - Speakers KW - Tongue KW - Context Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-399196 SN - 1866-8380 IS - 137 ER - TY - GEN A1 - Brunner, Jana A1 - Geng, Christian A1 - Sotiropoulou, Stavroula A1 - Gafos, Adamantios I. T1 - Timing of German onset and word boundary clusters T2 - Postprints der Universität Potsdam : Philosophische Reihe N2 - Previous studies suggest that there are special timing relations in syllable onsets. The consonants are assumed to be timed, on the one hand, with the vocalic nucleus and, on the other hand, with each other. These competing timing relations result in the C-center effect. However, the C-center effect has not consistently been found in languages with complex onsets. Moreover, it has occasionally been found in languages disallowing complex onsets. The present study investigates onset timing in German while discussing alternative explanations (not related to bonding) for the timing patterns observed. Six German speakers were recorded via Electromagnetic Articulography. The corpus contained items with four clusters (/sk/, /kv/, /gl/, and /pl/). The clusters occur in word-initial position, word-medial position, and across a word boundary preceding different vowels. The results suggest that segmental properties (i.e., oral-laryngeal coordination, coarticulatory resistance) determine the observed timing patterns, and specifically the absence or presence of the C-center effect. T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 136 KW - C-center KW - gestural coordination KW - coarticulatory resistance Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-399178 SN - 1866-8380 IS - 136 ER - TY - GEN A1 - Wiemann, Dirk T1 - George, Rosemary Marangoly, Indian English and the Fiction of National Literature / [reviewed by] Dirk Wiemann T2 - Postprints der Universität Potsdam : Philosophische Reihe N2 - Rezensiertes Werk: George, Rosemary Marangoly, Indian English and the Fiction of National Literature - Cambridge: Cambridge University Press, 2013. - Hb. viii, 285 pp. - (Zeitschrift für Anglistik und Amerikanistik ; 62(4)) ISBN 978-1-107-04000-7. T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 135 Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-398664 SN - 1866-8380 IS - 135 ER - TY - JOUR A1 - Wiemann, Dirk ED - Lange, Bernd-Peter ED - Bartels, Anke T1 - A Little Piece of the Shire BT - Some Versions of the Hobbit Garden JF - Hard times : deutsch-englische Zeitschrift Y1 - 2014 VL - 2014 IS - 95 SP - 24 EP - 27 ER - TY - JOUR A1 - Wiemann, Dirk T1 - George, Rosemary Marangoly, Indian English and the Fiction of National Literature / [rezensiert von] Dirk Wiemann JF - Zeitschrift für Anglistik und Amerikanistik : ZAA ; a quarterly of language, literature and culture N2 - Rezensiertes Werk George, Rosemary Marangoly, Indian English and the Fiction of National Literature - Cambridge: Cambridge University Press, 2013. - Hb. viii, 285 pp. - (Zeitschrift für Anglistik und Amerikanistik ; 62(4)) ISBN 978-1-107-04000-7. Y1 - 2014 U6 - https://doi.org/10.1515/zaa-2014-0039 SN - 0044-2305 SN - 2196-4726 VL - 62 IS - 4 SP - 385 EP - 388 PB - DeGruyter CY - Tübingen ER - TY - CHAP A1 - Wiemann, Dirk T1 - (Not) Readily Available : Kiran Nagarkar in the Global Market T2 - Indian Writing in English and the Global Literary Market Y1 - 2014 SN - 978-1-349-49386-9 SP - 180 EP - 197 PB - Palgrave CY - London ER - TY - CHAP A1 - Wiemann, Dirk T1 - Tolkien’s Baits : Agonism, Essentialism and the Visible in The Lord of the Rings T2 - Politics in Fantasy Media : Essays on Ideology and Gender in Fiction, Film, Television and Games Y1 - 2014 SP - 191 EP - 204 PB - McFarland CY - Jefferson, NC ER - TY - CHAP A1 - Wiemann, Dirk T1 - World Literary Spacing : Contemporary Verse Novels Across the Anglosphere T2 - Across Literary and Linguistic Diversities : Essays on Comparative Literature Y1 - 2014 SN - 978-3-0343-1759-7 SP - 45 EP - 62 PB - Lang CY - Oxford ER - TY - CHAP A1 - Wiemann, Dirk T1 - On (Not) Missing Links : reading Conan Doyle with Mahasweta Devi T2 - Afrofictional In(ter)ventions : revisiting the BIGSAS Festival of African (-Diasporic) Literatures, Bayreuth 2011-2013 Y1 - 2014 SN - 978-3-942885-67-6 SP - 269 EP - 282 PB - Edition Assemblage CY - Berlin ER - TY - JOUR A1 - Heyer, Vera A1 - Clahsen, Harald T1 - Late bilinguals see a scan in scanner AND in scandal: dissecting formal overlap from morphological priming in the processing of derived words JF - Bilingualism : language and cognition. N2 - Masked priming research with late (non-native) bilinguals has reported facilitation effects following morphologically derived prime words (scanner - scan). However, unlike for native speakers, there are suggestions that purely orthographic prime-target overlap (scandal - scan) also produces priming in non-native visual word recognition. Our study directly compares orthographically related and derived prime-target pairs. While native readers showed morphological but not formal overlap priming, the two prime types yielded the same magnitudes of facilitation for non-natives. We argue that early word recognition processes in a non-native language are more influenced by surface-form properties than in one's native language. KW - Masked priming KW - late bilinguals KW - derivation KW - orthographic overlap Y1 - 2014 U6 - https://doi.org/10.1017/S1366728914000662 SN - 1366-7289 SN - 1469-1841 VL - 18 IS - 3 SP - 543 EP - 550 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Lau, Stephan A1 - Kubiak, Thomas A1 - Burchert, Sebastian A1 - Goering, Mark A1 - Oberlaender, Nils A1 - von Mauschwitz, Hannes A1 - von Sass, Sarah A1 - Selle, Mareen A1 - Hiemisch, Anette T1 - Disentangling the effects of optimism and attributions on feelings of success JF - Personality and individual differences : an international journal of research into the structure and development of personality, and the causation of individual differences N2 - Two experiments examined the effects of dispositional optimism and attributions on feelings of success in a performance setting. In Experiment 1, participants successfully solved three cognitive tasks and attributed the success either internally (i.e., to themselves) or externally (i.e., to a teammate). We found no effect of optimism, but a significant effect of the attribution: Internal attribution predicted an increase in feelings of success. In Experiment 2, we replicated the design and adopted an extreme groups approach in order to include the extremes of the optimism dimension. Only optimism affected feelings of success in this sample: Pessimistic participants showed higher increases in feelings of success than optimistic participants. We conclude that optimism, if disentangled from attribution, may have an effect on affect, with pessimism showing potential affective benefits. However, this association may be concealed if samples with a restricted range of the optimism dimension are studied. KW - Optimism KW - Performance setting KW - Attribution KW - Success KW - Affect Y1 - 2014 U6 - https://doi.org/10.1016/j.paid.2013.08.030 SN - 0191-8869 VL - 56 SP - 78 EP - 82 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Banerjee, Shiladitya A1 - Saalfrank, Peter T1 - Vibrationally resolved absorption, emission and resonance Raman spectra of diamondoids: a study based on time-dependent correlation functions JF - Physical chemistry, chemical physics : a journal of European Chemical Societies Y1 - 2014 U6 - https://doi.org/10.1039/c3cp53535e SN - 1463-9076 SN - 1463-9084 VL - 16 IS - 1 SP - 144 EP - 158 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - von Websky, Karoline A1 - Reichetzeder, Christoph A1 - Hocher, Berthold T1 - Physiology and pathophysiology of incretins in the kidney JF - Current opinion in nephrology and hypertension : reviews of all advances, evaluations of key references, comprehensive listing of papers N2 - Purpose of reviewIncretin-based therapy with glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors is considered a promising therapeutic option for type 2 diabetes mellitus. Cumulative evidence, mainly from preclinical animal studies, reveals that incretin-based therapies also may elicit beneficial effects on kidney function. This review gives an overview of the physiology, pathophysiology, and pharmacology of the renal incretin system.Recent findingsActivation of GLP-1R in the kidney leads to diuretic and natriuretic effects, possibly through direct actions on renal tubular cells and sodium transporters. Moreover, there is evidence that incretin-based therapy reduces albuminuria, glomerulosclerosis, oxidative stress, and fibrosis in the kidney, partially through GLP-1R-independent pathways. Molecular mechanisms by which incretins exert their renal effects are understood incompletely, thus further studies are needed.SummaryThe GLP-1R and DPP-4 are expressed in the kidney in various species. The kidney plays an important role in the excretion of incretin metabolites and most GLP-1R agonists and DPP-4 inhibitors, thus special attention is required when applying incretin-based therapy in renal impairment. Preclinical observations suggest direct renoprotective effects of incretin-based therapies in the setting of hypertension and other disorders of sodium retention, as well as in diabetic and nondiabetic nephropathy. Clinical studies are needed in order to confirm translational relevance from preclinical findings for treatment options of renal diseases. KW - DDP-4 inhibition KW - diabetes KW - diabetic nephropathy KW - GLP-1 receptor KW - hypertension KW - incretins KW - kidney KW - renal impairment Y1 - 2014 U6 - https://doi.org/10.1097/01.mnh.0000437542.77175.a0 SN - 1062-4821 SN - 1473-6543 VL - 23 IS - 1 SP - 54 EP - 60 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Mondal, Suvendu Sekhar A1 - Bhunia, Asamanjoy A1 - Demeshko, Serhiy A1 - Kelling, Alexandra A1 - Schilde, Uwe A1 - Janiak, Christoph A1 - Holdt, Hans-Jürgen T1 - Synthesis of a Co(II)-imidazolate framework from an anionic linker precursor: gas-sorption and magnetic properties JF - CrystEngComm N2 - A Co(II)-imidazolate-4-amide-5-imidate based MOF, IFP-5, is synthesized by using an imidazolate anion-based novel ionic liquid as a linker precursor under solvothermal conditions. IFP-5 shows significant amounts of gas (N-2, CO2, CH4 and H-2) uptake capacities. IFP-5 exhibits an independent high spin Co(II) centre and antiferromagnetic coupling. Y1 - 2014 U6 - https://doi.org/10.1039/c3ce42040j SN - 1466-8033 VL - 16 IS - 1 SP - 39 EP - 42 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Alsaedy, Ammar A1 - Tarkhanov, Nikolai Nikolaevich T1 - Normally solvable nonlinear boundary value problems JF - Nonlinear analysis : theory, methods & applications ; an international multidisciplinary journal N2 - We investigate nonlinear problems which appear as Euler-Lagrange equations for a variational problem. They include in particular variational boundary value problems for nonlinear elliptic equations studied by F. Browder in the 1960s. We establish a solvability criterion of such problems and elaborate an efficient orthogonal projection method for constructing approximate solutions. KW - Nonlinear Laplace operator KW - Boundary value problem KW - Dirichlet to Neumann operator Y1 - 2014 U6 - https://doi.org/10.1016/j.na.2013.09.024 SN - 0362-546X SN - 1873-5215 VL - 95 SP - 468 EP - 482 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Borck, Rainald A1 - Wimbersky, Martin T1 - Political economics of higher education finance JF - Oxford economic papers Y1 - 2014 U6 - https://doi.org/10.1093/oep/gps042 SN - 0030-7653 SN - 1464-3812 VL - 66 IS - 1 SP - 115 EP - 139 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Tu, Rui A1 - Ge, Maorong A1 - Wang, Rongjiang A1 - Walter, Thomas R. T1 - A new algorithm for tight integration of real-time GPS and strong-motion records, demonstrated on simulated, experimental, and real seismic data JF - Journal of seismology N2 - The complementary advantages of GPS and seismic measurements are well recognized in seismotectonic monitoring studies. Therefore, integrated processing of the two data streams has been proposed recently in an attempt to obtain accurate and reliable information of surface displacements associated with earthquakes. A hitherto still critical issue in the integrated processing is real-time detection and precise estimation of the transient baseline error in the seismic records. Here, we report on a new approach by introducing the seismic acceleration corrected by baseline errors into the state equation system. The correction is performed and regularly updated in short epochs (with increments which may be as short as seconds), so that station position, velocity, and acceleration can be constrained very tightly and baseline error can be estimated as a random-walk process. With the adapted state equation system, our study highlights the use of a new approach developed for integrated processing of GPS and seismic data by means of sequential least-squares adjustment. The efficiency of our approach is demonstrated and validated using simulated, experimental, and real datasets. The latter were collected at collocated GPS and seismic stations around the 4 April 2010, E1 Mayor-Cucapah earthquake (Mw, 7.2). The results have shown that baseline errors of the strong-motion sensors are corrected precisely and high-precision seismic displacements are real-timely obtained by the new approach. KW - High-rateGPS KW - Strong-motion records KW - Baseline error KW - Tight integration KW - Precise point positioning Y1 - 2014 U6 - https://doi.org/10.1007/s10950-013-9408-x SN - 1383-4649 SN - 1573-157X VL - 18 IS - 1 SP - 151 EP - 161 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Zohsel, Katrin A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Mothers' prenatal stress and their children's antisocial outcomes - a moderating role for the dopamine receptor D4 (DRD4) gene JF - The journal of child psychology and psychiatry N2 - ResultsUnder conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. ConclusionsThis study is the first to report a gene-environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior. KW - Prenatal stress KW - antisocial KW - conduct disorder KW - DRD4 KW - gene-environment interaction Y1 - 2014 U6 - https://doi.org/10.1111/jcpp.12138 SN - 0021-9630 SN - 1469-7610 VL - 55 IS - 1 SP - 69 EP - 76 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Reinecke, Jennifer A1 - Klemm, Gunther A1 - Heinken, Thilo T1 - Vegetation change and homogenization of species composition in temperate nutrient deficient scots pine forests after 45 yr JF - Journal of vegetation science N2 - QuestionDoes eutrophication drive vegetation change in pine forests on nutrient deficient sites and thus lead to the homogenization of understorey species composition? LocationForest area (1600ha) in the Lower Spreewald, Brandenburg, Germany. MethodsResurvey of 77 semi-permanent plots after 45yr, including vascular plants, bryophytes and ground lichens. We applied multidimensional ordination of species composition, dissimilarity indices, mean Ellenberg indicator values and the concept of winner/loser species to identify vegetation change between years. Differential responses along a gradient of nutrient availability were analysed on the basis of initial vegetation type, reflecting topsoil N availability of plots. ResultsSpecies composition changed strongly and overall shifted towards higher N and slightly lower light availability. Differences in vegetation change were related to initial vegetation type, with strongest compositional changes in the oligotrophic forest type, but strongest increase of nitrophilous species in the mesotrophic forest type. Despite an overall increase in species number, species composition was homogenized between study years due to the loss of species (mainly ground lichens) on the most oligotrophic sites. ConclusionsThe response to N enrichment is confounded by canopy closure on the N-richest sites and probably by water limitation on N-poorest sites. The relative importance of atmospheric N deposition in the eutrophication effect is difficult to disentangle from natural humus accumulation after historical litter raking. However, the profound differences in species composition between study years across all forest types suggest that atmospheric N deposition contributes to the eutrophication, which drives understorey vegetation change and biotic homogenization in Central European Scots pine forests on nutrient deficient sites. KW - Eutrophication KW - Litter raking KW - Canopy closure KW - Cryptogams KW - Species diversity Y1 - 2014 U6 - https://doi.org/10.1111/jvs.12069 SN - 1100-9233 SN - 1654-1103 VL - 25 IS - 1 SP - 113 EP - 121 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Spalek, Katharina A1 - Gotzner, Nicole A1 - Wartenburger, Isabell T1 - Not only the apples BT - Focus sensitive particles improve memory for information-structural alternatives JF - Journal of memory and language : JML N2 - Focus sensitive particles highlight the relevance of contextual alternatives for the interpretation of a sentence. Two experiments tested whether this leads to better encoding and therefore, ultimately, better recall of focus alternatives. Participants were presented with auditory stimuli that introduced a set of elements ("context sentence") and continued in three different versions: the critical sentences either contained the exclusive particle nur ("only"), the inclusive particle sogar ("even"), or no particle (control condition). After being exposed to blocks of ten trials, participants were asked to recall the elements in the context sentence. The results show that both particles enhanced memory performance for the alternatives to the focused element, relative to the control condition. The results support the assumption that information-structural alternatives are better encoded in memory in the presence of a focus sensitive particle. KW - Information structure KW - Focus particles KW - Alternative set KW - Delayed recall KW - Memory Y1 - 2014 U6 - https://doi.org/10.1016/j.jml.2013.09.001 SN - 0749-596X SN - 1096-0821 VL - 70 SP - 68 EP - 84 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Lohmann, Dirk A1 - Falk, Thomas A1 - Geissler, Katja A1 - Blaum, Niels A1 - Jeltsch, Florian T1 - Determinants of semi-arid rangeland management in a land reform setting in Namibia JF - Journal of arid environments N2 - To assess the ecological and economic implications of the redistributive land reform in semi-arid Namibia, we investigated to what extent land reform beneficiaries adjust herd size and herd composition according to environmental (rainfall, vegetation) and economic variables (herd size, financial assets, running costs). We performed model-based role-plays with Namibian land reform beneficiaries, simulating 10 years of rangeland management. Our study revealed that the farmers surveyed mainly manage their herds according to their economic situation (herd size and account balance) but do not take environmental variability (rainfall and vegetation) into account. Further, our results indicate that, due to financial pressure, farmers are not able to apply their desired management strategies, and that owners of small farms face a higher risk of economic failure. However, farmers apply rather conservative and constant stocking rates and will thus, given the current economic limitations, likely not contribute to semi-arid savanna degradation. We conclude that land reform beneficiaries need support to be able to apply straightforward and efficient management strategies. This could be achieved by facilitating cooperation between small farming businesses and by supporting initial investment in productive cattle herds at the time of redistribution of the land. KW - Dry land degradation KW - Semi-arid savanna KW - Land reform KW - Rangeland management KW - Simulation model KW - Role-play Y1 - 2014 U6 - https://doi.org/10.1016/j.jaridenv.2013.10.005 SN - 0140-1963 SN - 1095-922X VL - 100 SP - 23 EP - 30 PB - Elsevier CY - London ER - TY - JOUR A1 - Passow, Susanne A1 - Westerhausen, Rene A1 - Hugdahl, Kenneth A1 - Wartenburger, Isabell A1 - Heekeren, Hauke R. A1 - Lindenberger, Ulman A1 - Li, Shu-Chen T1 - Electrophysiological correlates of adult age differences in attentional control of auditory processing JF - Cerebral cortex N2 - In addition to sensory decline, age-related losses in auditory perception also reflect impairments in attentional modulation of perceptual saliency. Using an attention and intensity-modulated dichotic listening paradigm, we investigated electrophysiological correlates of processing conflicts between attentional focus and perceptual saliency in 25 younger and 26 older adults. Participants were instructed to attend to the right or left ear, and perceptual saliency was manipulated by varying the intensities of both ears. Attentional control demand was higher in conditions when attentional focus and perceptual saliency favored opposing ears than in conditions without such conflicts. Relative to younger adults, older adults modulated their attention less flexibly and were more influenced by perceptual saliency. Our results show, for the first time, that in younger adults a late negativity in the event-related potential (ERP) at fronto-central and parietal electrodes was sensitive to perceptual-attentional conflicts during auditory processing (N450 modulation effect). Crucially, the magnitude of the N450 modulation effect correlated positively with task performance. In line with lower attentional flexibility, the ERP waveforms of older adults showed absence of the late negativity and the modulation effect. This suggests that aging compromises the activation of the frontoparietal attentional network when processing the competing and conflicting auditory information. KW - aging KW - attention KW - auditory perception KW - conflict monitoring KW - ERP Y1 - 2014 U6 - https://doi.org/10.1093/cercor/bhs306 SN - 1047-3211 SN - 1460-2199 VL - 24 IS - 1 SP - 249 EP - 260 PB - Oxford Univ. Press CY - Cary ER - TY - JOUR A1 - Sarkar, Saswati A1 - Wilkes, Heinz A1 - Prasad, Sushma A1 - Brauer, Achim A1 - Riedel, Nils A1 - Stebich, Martina A1 - Basavaiah, Nathani A1 - Sachse, Dirk T1 - Spatial heterogeneity in lipid biomarker distributions in the catchment and sediments of a crater lake in central India JF - Organic geochemistry : the international journal for rapid publication of current research in organic geochemistry and biochemistry N2 - The basin-scale spatial variability in lipid biomarker proxies in lacustrine sediments, which are established tools for studying continental environmental change, has rarely been examined. It is often implicitly assumed that a lake sediment core provides an average integral of catchment sources. Here we evaluated the distribution of lipid biomarkers in a modern ecosystem and compared it with the sedimentary record. We analyzed lipid biomarkers in terrestrial and aquatic organisms and in lake surface sediments from 17 locations within the saline-alkaline Lonar crater lake in central India. Terrestrial vegetation and lake surface sediments were characterized by relatively high average chain length (ACL) index values (29.6-32.8) of leaf wax n-alkanes, consistent with suggestions that plants in drier and warmer climates produce longer chain alkyl lipids than plants in cooler and humid areas. A heterogeneous spatial distribution of ACL values in lake surface sediments was found: at locations away from the shore, the values were highest (31 or more), possibly indicating different sources and/or transport of terrestrial biomarkers. In floating, benthic microbial mats and surface sediment, n-heptadecane, carotenoids, diploptene, phytol and tetrahymanol occurred in large amounts. Interestingly, these biomarkers of a unique bacterial community were found in substantially higher concentrations in nearshore sediment samples. We suggest that human influence and subsequent nutrient supply resulted in increased primary productivity, leading to an unusually high concentration of tetrahymanol in the nearshore sediments. In summary, the data showed that substantial heterogeneity existed within the lake, but leaf wax n-alkanes in a core from the center of the lake represented an integral of catchment conditions. However, lake level fluctuation may potentially affect aquatic lipid biomarker distributions in lacustrine sediments, in addition to source changes. Y1 - 2014 U6 - https://doi.org/10.1016/j.orggeochem.2013.11.009 SN - 0146-6380 VL - 66 SP - 125 EP - 136 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Vandewal, Koen A1 - Albrecht, Steve A1 - Hoke, Eric T. A1 - Graham, Kenneth R. A1 - Widmer, Johannes A1 - Douglas, Jessica D. A1 - Schubert, Marcel A1 - Mateker, William R. A1 - Bloking, Jason T. A1 - Burkhard, George F. A1 - Sellinger, Alan A1 - Frechet, Jean M. J. A1 - Amassian, Aram A1 - Riede, Moritz K. A1 - McGehee, Michael D. A1 - Neher, Dieter A1 - Salleo, Alberto T1 - Efficient charge generation by relaxed charge-transfer states at organic interfaces JF - Nature materials N2 - carriers on illumination. Efficient organic solar cells require a high yield for this process, combined with a minimum of energy losses. Here, we investigate the role of the lowest energy emissive interfacial charge-transfer state (CT1) in the charge generation process. We measure the quantum yield and the electric field dependence of charge generation on excitation of the charge-transfer (CT) state manifold viaweakly allowed, low-energy optical transitions. For a wide range of photovoltaic devices based on polymer: fullerene, small-molecule:C-60 and polymer: polymer blends, our study reveals that the internal quantum efficiency (IQE) is essentially independent of whether or not D, A or CT states with an energy higher than that of CT1 are excited. The best materials systems show an IQE higher than 90% without the need for excess electronic or vibrational energy. Y1 - 2014 U6 - https://doi.org/10.1038/NMAT3807 SN - 1476-1122 SN - 1476-4660 VL - 13 IS - 1 SP - 63 EP - 68 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Hohenstein, Sven A1 - Kliegl, Reinhold T1 - Semantic preview benefit during reading JF - Journal of experimental psychology : Learning, memory, and cognition N2 - Word features in parafoveal vision influence eye movements during reading. The question of whether readers extract semantic information from parafoveal words was studied in 3 experiments by using a gaze-contingent display change technique. Subjects read German sentences containing 1 of several preview words that were replaced by a target word during the saccade to the preview (boundary paradigm). In the 1st experiment the preview word was semantically related or unrelated to the target. Fixation durations on the target were shorter for semantically related than unrelated previews, consistent with a semantic preview benefit. In the 2nd experiment, half the sentences were presented following the rules of German spelling (i.e., previews and targets were printed with an initial capital letter), and the other half were presented completely in lowercase. A semantic preview benefit was obtained under both conditions. In the 3rd experiment, we introduced 2 further preview conditions, an identical word and a pronounceable nonword, while also manipulating the text contrast. Whereas the contrast had negligible effects, fixation durations on the target were reliably different for all 4 types of preview. Semantic preview benefits were greater for pretarget fixations closer to the boundary (large preview space) and, although not as consistently, for long pretarget fixation durations (long preview time). The results constrain theoretical proposals about eye movement control in reading. KW - eye movements KW - reading KW - semantic preview benefit KW - parafoveal processing KW - display change awareness Y1 - 2014 U6 - https://doi.org/10.1037/a0033670 SN - 0278-7393 SN - 1939-1285 VL - 40 IS - 1 SP - 166 EP - 190 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Polyvyanyy, Artem A1 - Garcia-Banuelos, Luciano A1 - Fahland, Dirk A1 - Weske, Mathias T1 - Maximal structuring of acyclic process models JF - The computer journal : a publication of the British Computer Society N2 - This article addresses the transformation of a process model with an arbitrary topology into an equivalent structured process model. In particular, this article studies the subclass of process models that have no equivalent well-structured representation but which, nevertheless, can be partially structured into their maximally-structured representation. The transformations are performed under a behavioral equivalence notion that preserves the observed concurrency of tasks in equivalent process models. The article gives a full characterization of the subclass of acyclic process models that have no equivalent well-structured representation, but do have an equivalent maximally-structured one, as well as proposes a complete structuring method. Together with our previous results, this article completes the solution of the process model structuring problem for the class of acyclic process models. KW - process modeling KW - structured process model KW - maximal structuring KW - model transformation KW - fully concurrent bisimulation Y1 - 2014 U6 - https://doi.org/10.1093/comjnl/bxs126 SN - 0010-4620 SN - 1460-2067 VL - 57 IS - 1 SP - 12 EP - 35 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Nicolas, Philippe A1 - Lecourieux, David A1 - Kappel, Christian A1 - Cluzet, Stephanie A1 - Cramer, Grant A1 - Delrot, Serge A1 - Lecourieux, Fatma T1 - The basic leucine zipper transcription factor abscisic acid responseelement-binding factor 2 is an important transcriptional regulator ofabscisic acid-dependent grape berry ripening processes JF - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants N2 - In grape (Vitis vinifera), abscisic acid (ABA) accumulates during fruit ripening and is thought to play a pivotal role in this process, but the molecular basis of this control is poorly understood. This work characterizes ABSCISIC ACID RESPONSE ELEMENT-BINDING FACTOR2 (VvABF2), a grape basic leucine zipper transcription factor belonging to a phylogenetic subgroup previously shown to be involved in ABA and abiotic stress signaling in other plant species. VvABF2 transcripts mainly accumulated in the berry, from the onset of ripening to the harvesting stage, and were up-regulated by ABA. Microarray analysis of transgenic grape cells overexpressing VvABF2 showed that this transcription factor up-regulates and/or modifies existing networks related to ABA responses. In addition, grape cells overexpressing VvABF2 exhibited enhanced responses to ABA treatment compared with control cells. Among the VvABF2-mediated responses highlighted in this study, the synthesis of phenolic compounds and cell wall softening were the most strongly affected. VvABF2 overexpression strongly increased the accumulation of stilbenes that play a role in plant defense and human health (resveratrol and piceid). In addition, the firmness of fruits from tomato (Solanum lycopersicum) plants overexpressing VvABF2 was strongly reduced. These data indicate that VvABF2 is an important transcriptional regulator of ABA-dependent grape berry ripening. Y1 - 2014 U6 - https://doi.org/10.1104/pp.113.231977 SN - 0032-0889 SN - 1532-2548 VL - 164 IS - 1 SP - 365 EP - 383 PB - American Society of Plant Physiologists CY - Rockville ER - TY - JOUR A1 - Cherstvy, Andrey G. A1 - Petrov, Eugene P. T1 - Modeling DNA condensation on freestanding cationic lipid membranes JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - Motivated by recent experimental observations of a rapid spontaneous DNA coil-globule transition on freestanding cationic lipid bilayers, we propose simple theoretical models for DNA condensation on cationic lipid membranes. First, for a single DNA rod, we examine the conditions of full wrapping of a cylindrical DNA-like semi-flexible polyelectrolyte by an oppositely charged membrane. Then, for two parallel DNA rods, we self-consistently analyze the shape and the extent of the membrane enveloping them, focusing on membrane elastic deformations and the membrane-DNA embracing angle, which enables us to compute the membrane-mediated DNA-DNA interactions. We examine the effects of the membrane composition and its charge density, which are the experimentally tunable parameters. We show that membrane-driven rod-rod attraction is more pronounced for higher charge densities and for smaller surface tensions of the membrane. Thus, we demonstrate that for a long DNA chain adhered to a cationic lipid membrane, such membrane-induced DNA-DNA attraction can trigger compaction of DNA. Y1 - 2014 U6 - https://doi.org/10.1039/c3cp53433b SN - 1463-9076 SN - 1463-9084 VL - 16 IS - 5 SP - 2020 EP - 2037 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Shaki, Samuel A1 - Fischer, Martin H. T1 - Random walks on the mental number line JF - Experimental brain research KW - Mental number line KW - RNG KW - SNARC KW - Spatial bias KW - Walking Y1 - 2014 U6 - https://doi.org/10.1007/s00221-013-3718-7 SN - 0014-4819 SN - 1432-1106 VL - 232 IS - 1 SP - 43 EP - 49 PB - Springer CY - New York ER - TY - JOUR A1 - Ballato, Paolo A1 - Strecker, Manfred T1 - Assessing tectonic and climatic causal mechanisms in foreland-basin stratal architecture: insights from the Alborz Mountains, northern Iran JF - Earth surface processes and landforms : the journal of the British Geomorphological Research Group N2 - The southern foreland basin of the Alborz Mountains of northern Iran is characterized by an approximately 7.3-km-thick sequence of Miocene sedimentary rocks, constituting three basin-wde coarsening-upward units spanning a period of 10(6)years. We assess available magnetostratigraphy, paleoclimatic reconstructions, stratal architecture, records of depositional environments, and sediment-provenance data to characterize the relationships between tectonically-generated accommodation space (A) and sediment supply (S). Our analysis allows an inversion of the stratigraphy for particular forcing mechanisms, documenting causal relationships, and providing a basis to decipher the relative contributions of tectonics and climate (inferred changes in precipitation) in controlling sediment supply to the foreland basin. Specifically, A/S>1, typical of each basal unit (17.5-16.0, 13.8-13.1 and 10.3-9.6Ma), is associated with sharp facies retrogradation and reflects substantial tectonic subsidence. Within these time intervals, arid climatic conditions, changes in sediment provenance, and accelerated exhumation in the orogen suggest that sediment supply was most likely driven by high uplift rates. Conversely, A/S<1 (13.8 and 13.8-11Ma, units 1, and 2) reflects facies progradation during a sharp decline in tectonic subsidence caused by localized intra-basinal uplift. During these time intervals, climate continued to be arid and exhumation active, suggesting that sediment supply was again controlled by tectonics. A/S<1, at 11-10.3Ma and 9-6-7.6Ma (and possibly 6.2; top of units 2 and 3), is also associated with two episodes of extensive progradation, but during wetter phases. The first episode appears to have been linked to a pulse in sediment supply driven by an increase in precipitation. The second episode reflects a balance between a climatically-induced increase in sediment supply and a reduction of subsidence through the incorporation of the proximal foreland into the orogenic wedge. This in turn caused an expansion of the catchment and a consequent further increase in sediment supply. KW - sediment supply KW - climatic and tectonic forcing KW - accommodation-space KW - sediment-supply ratio (A /S) KW - foreland-basin stratigraphy KW - Alborz Mountains Y1 - 2014 U6 - https://doi.org/10.1002/esp.3480 SN - 0197-9337 SN - 1096-9837 VL - 39 IS - 1 SP - 110 EP - 125 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Baroni, Gabriele A1 - Tarantola, S. T1 - A general probabilistic framework for uncertainty and global sensitivity analysis of deterministic models: A hydrological case study JF - Environmental modelling & software with environment data news N2 - The present study proposes a General Probabilistic Framework (GPF) for uncertainty and global sensitivity analysis of deterministic models in which, in addition to scalar inputs, non-scalar and correlated inputs can be considered as well. The analysis is conducted with the variance-based approach of Sobol/Saltelli where first and total sensitivity indices are estimated. The results of the framework can be used in a loop for model improvement, parameter estimation or model simplification. The framework is applied to SWAP, a 113 hydrological model for the transport of water, solutes and heat in unsaturated and saturated soils. The sources of uncertainty are grouped in five main classes: model structure (soil discretization), input (weather data), time-varying (crop) parameters, scalar parameters (soil properties) and observations (measured soil moisture). For each source of uncertainty, different realizations are created based on direct monitoring activities. Uncertainty of evapotranspiration, soil moisture in the root zone and bottom fluxes below the root zone are considered in the analysis. The results show that the sources of uncertainty are different for each output considered and it is necessary to consider multiple output variables for a proper assessment of the model. Improvements on the performance of the model can be achieved reducing the uncertainty in the observations, in the soil parameters and in the weather data. Overall, the study shows the capability of the GPF to quantify the relative contribution of the different sources of uncertainty and to identify the priorities required to improve the performance of the model. The proposed framework can be extended to a wide variety of modelling applications, also when direct measurements of model output are not available. KW - Global sensitivity analysis KW - Non-scalar input factors KW - Hydrological model KW - Multi-variables Y1 - 2014 U6 - https://doi.org/10.1016/j.envsoft.2013.09.022 SN - 1364-8152 SN - 1873-6726 VL - 51 SP - 26 EP - 34 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Henrichs, Ivanina A1 - Elsner, Claudia A1 - Elsner, Birgit A1 - Wilkinson, Nick A1 - Gredeback, Gustaf T1 - Goal certainty modulates infants' goal-directed gaze shifts JF - Developmental psychology N2 - We investigated whether 12-month-old infants rely on information about the certainty of goal selection in order to predict observed reaching actions. Infants' goal-directed gaze shifts were recorded as they observed action sequences in a multiple-goals design. We found that 12-month-old infants exhibited gaze shifts significantly earlier when the observed hand reached for the same goal object in all trials (frequent condition) compared with when the observed hand reached for different goal objects across trials (nonfrequent condition). Infants in the frequent condition were significantly more accurate at predicting the action goal than infants in the nonfrequent condition. In addition, findings revealed rapid learning in the case of certainty and no learning in the case of uncertainty of goal selection over the course of trials. Together, our data indicate that by the end of their first year of life, infants rely on information about the certainty of goal selection to make inferences about others' action goals. KW - anticipation KW - eye movement KW - infant KW - direct matching KW - statistical learning Y1 - 2014 U6 - https://doi.org/10.1037/a0032664 SN - 0012-1649 SN - 1939-0599 VL - 50 IS - 1 SP - 100 EP - 107 PB - American Psychological Association CY - Washington ER -