TY  - JOUR
A1  - Wengenmayer, Christina
A1  - Krikov, Maxim
A1  - Mueller, Susanne
A1  - Lucht, Kristin
A1  - Villringer, Arno
A1  - Hocher, Berthold
A1  - Unger, Thomas
A1  - Thoene-Reineke, Christa
T1  - Novel therapy approach in primary stroke prevention simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival
JF  - Neurological research : a journal of progress in neurosurgery and neurosciences
N2  - Objectives: Stroke, frequently a consequence of hypertension, is one of the leading causes of death and neurological disabilities worldwide. In the ischemic brain, levels of endothelin-1, one of the most potent vasoconstrictors, are raised. Anti-inflammatory and neuroprotective effects of endothelin antagonists after stroke have been described in literature. Based on these findings, we investigated the protective effect of the endothelin converting enzyme/neutral endopeptidase blocker, SLV 338, in salt-loaded, stroke-prone, spontaneously hypertensive rats.
 Methods: Male, 8-week-old spontaneously hypertensive stroke-prone rats were put on a high salt diet and treated with either 30 mg/kg or 100 mg/kg SLV 338 or vehicle for 27 weeks. Blood pressure, neurological outcome, body weight, and mortality were investigated throughout treatment. In weeks 1 and 9, animals were housed in metabolic cages for collection of urinary and blood samples and assessment of salt water and food intake. In weeks 22 and 27, additional blood samples were taken. At the end of the study, all brains were analyzed using magnetic resonance imaging.
 Results: SLV 338 was well tolerated in all animals. Neurological outcome and infarct size were similar in all groups. Albuminuria was considerably delayed and the incidence of stroke significantly lowered in treated animals. In spontaneously hypertensive stroke-prone rats, treatment with SLV 338 significantly (P=0.01) improved survival in comparison to the vehicle treated group in a blood pressure-independent manner.
 Discussion: Our data in spontaneously hypertensive stroke-prone rats demonstrate that combined endothelin converting enzyme/neutral endopeptidase inhibition could offer a new therapeutic approach for primary stroke prevention and improvement of mortality. The mechanism seems to be blood pressure-independent.
KW  - Endothelin
KW  - Hypertension
KW  - Natriuretic peptides
KW  - Stroke
Y1  - 2011
U6  - https://doi.org/10.1179/016164111X12881719352534
SN  - 0161-6412
VL  - 33
IS  - 2
SP  - 201
EP  - 207
PB  - Routledge, Taylor & Francis Group
CY  - Leeds
ER  - 
TY  - JOUR
A1  - Wartenburger, Isabell
A1  - Heekeren, Hauke R.
A1  - Burchert, Frank
A1  - Heinemann, Steffi
A1  - De Bleser, Ria
A1  - Villringer, Arno
T1  - Neural correlates of syntactic transformations
N2  - Many agrammatic aphasics have a specific syntactic comprehension deficit involving processing syntactic transformations. It has been proposed that this deficit is due to a dysfunction of Broca's area, an area that is thought to be critical for comprehension of complex transformed sentences. The goal of this study was to investigate the role of Broca's area in processing canonical and non-canonical sentences in healthy subjects. The sentences were presented auditorily and were controlled for task difficulty. Subjects were asked to judge the grammaticality of the sentences while their brain activity was monitored using event-related functional magnetic resonance imaging. Processing both kinds of sentences resulted in activation of language-related brain regions. Comparison of non-canonical and canonical sentences showed greater activation in bilateral temporal regions; a greater activation of Broca's area in processing antecedent-gap relations was not found. Moreover, the posterior part of Broca's area was conjointly activated by both sentence conditions. Broca's area is thus involved in general syntactic processing as required by grammaticality judgments and does not seem to have a specific role in processing syntactic transformations. (C) 2004 Wiley-Liss, Inc
Y1  - 2004
UR  - http://www3.interscience.wiley.com/journal/38751/home
SN  - 1065-9471
ER  - 
TY  - JOUR
A1  - Wartenburger, Isabell
A1  - Heekeren, Hauke R.
A1  - Abutalebi, Jubin
A1  - Cappa, Stefano F.
A1  - Villringer, Arno
A1  - Perani, Daniela
T1  - Early setting of grammatical processing in the bilingual brain
Y1  - 2003
UR  - http://www.cell.com/neuron/home
SN  - 0896-6273
ER  - 
TY  - JOUR
A1  - Wartenburger, Isabell
A1  - Burchert, Frank
A1  - Heekeren, Hauke R.
A1  - De Bleser, Ria
A1  - Villringer, Arno
T1  - Grammaticality judgments on sentences with and without movement of phrasal constituents : an event-related fMRI study
Y1  - 2003
UR  - http://www.sciencedirect.com/science/journal/09116044
SN  - 0911-6044
ER  - 
TY  - JOUR
A1  - Scheibe, Christina
A1  - Wartenburger, Isabell
A1  - Wüstenberg, Torsten
A1  - Kathmann, Norbert
A1  - Villringer, Arno
A1  - Heekeren, Hauke R.
T1  - Neural correlates of the interaction between transient and sustained processes : a mixed blocked/event-related fMRI study
Y1  - 2006
UR  - http://www3.interscience.wiley.com/journal/38751/home
SN  - 1065-9471
ER  - 
TY  - JOUR
A1  - Prehn, Kristin
A1  - Wartenburger, Isabell
A1  - Mériau, Katja
A1  - Scheibe, Christina
A1  - Goodenough, Oliver R.
A1  - Villringer, Arno
A1  - van der Meer, Elke
A1  - Heekeren, Hauke R.
T1  - Individual differences in moral judgment competence influence neural correlates of socio-normative judgments
Y1  - 2008
UR  - http://scan.oxfordjournals.org/content/by/year
SN  - 1749-5016
ER  - 
TY  - JOUR
A1  - Mériau, Katja
A1  - Wartenburger, Isabell
A1  - Kazzer, Philipp
A1  - Prehn, Kristin
A1  - Villringer, Arno
A1  - van der Meer, Elke
A1  - Heekeren, Hauke R.
T1  - Insular activity during passive viewing of aversive stimuli reflects individual differences in state negative affect
N2  - People differ with regard to how they perceive, experience, and express negative affect. While trait negative affect reflects a stable, sustained personality trait, state negative affect represents a stimulus limited and temporally acute emotion. So far, little is known about the neural systems mediating the relationship between negative affect and acute emotion processing. To address this issue we investigated in a healthy female sample how individual differences in state negative affect are reflected in changes in blood oxygen level-dependent responses during passive viewing of emotional stimuli. To assess autonomic arousal we simultaneously recorded changes in skin conductance level. At the psychophysiological level we found increased skin conductance level in response to aversive relative to neutral pictures. However, there was no association of state negative affect with skin conductance level. At the neural level we found that high state negative affect was associated with increased left insular activity during passive viewing of aversive stimuli. The insula has been implicated in interoceptive processes and in the integration of sensory, visceral, and affective information thus contributing to subjective emotional experience. Greater recruitment of the insula in response to aversive relative to neutral stimuli in subjects with high state negative affect may represent increased processing of salient aversive stimuli.
Y1  - 2009
UR  - http://www.sciencedirect.com/science/journal/02782626
U6  - https://doi.org/10.1016/j.bandc.2008.05.006
SN  - 0278-2626
ER  - 
TY  - JOUR
A1  - Mériau, Katja
A1  - Wartenburger, Isabell
A1  - Kazzer, Philipp
A1  - Prehn, Kristin
A1  - Lammers, Claas-Hinrich
A1  - van der Meer, Elke
A1  - Villringer, Arno
A1  - Heekeren, Hauke R.
T1  - A neural network reflecting individual differences in cognitive processing of emotions during perceptual decision making
Y1  - 2006
SN  - 1053-8119
ER  - 
TY  - JOUR
A1  - Mériau, Katja
A1  - Kazzer, Philipp
A1  - Wartenburger, Isabell
A1  - Prehn, Kristin
A1  - Lammers, Claas-Hinrich
A1  - Villringer, Arno
A1  - Heekeren, Hauke
T1  - Neural correlates of individual differences in the ability to identify and communicate one's emotional state
Y1  - 2005
SN  - 0898-929X
ER  - 
TY  - GEN
A1  - Mell, Thomas
A1  - Wartenburger, Isabell
A1  - Marschner, Alexander
A1  - Villringer, Arno
A1  - Reischies, Friedel M.
A1  - Heekeren, Hauke R.
T1  - Altered function of ventral striatum during reward-based decision making in old age
N2  - Normal aging is associated with a decline in different cognitive domains and local structural atrophy as well as decreases in dopamine concentration and receptor density. To date, it is largely unknown how these reductions in dopaminergic neurotransmission affect human brain regions responsible for reward-based decision making in older adults. Using a learning criterion in a probabilistic object reversal task, we found a learning stage by age interaction in the dorsolateral prefrontal cortex (dIPFC) during decision making. While young adults recruited the dlPFC in an early stage of learning reward associations, older adults recruited the dlPFC when reward associations had already been learned. Furthermore, we found a reduced change in ventral striatal BOLD signal in older as compared to younger adults in response to high probability rewards. Our data are in line with behavioral evidence that older adults show altered stimulus-reward learning and support the view of an altered fronto-striatal interaction during reward-based decision making in old age, which contributes to prolonged learning of reward associations.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - paper 182 
KW  - aging
KW  - fMRI
KW  - reward association learning
KW  - ventral striatum
KW  - decision making
KW  - dorsolateral prefrontal cortex
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45235
ER  - 
TY  - JOUR
A1  - Mell, Thomas
A1  - Heekeren, Hauke R.
A1  - Marschner, Alexander
A1  - Wartenburger, Isabell
A1  - Villringer, Arno
A1  - Reischies, Friedel M.
T1  - Effect of aging on stimulus-reward association learning
N2  - The flexible learning of stimulus-reward associations when required by situational context is essential for everyday behavior. Older adults experience a progressive decline in several cognitive functions and show deficiencies in neuropsychological tasks requiring flexible adaptation to external feedback, which could be related to impairments in reward association learning. To study the effect of aging on stimulus-reward association learning 20 young and 20 older adults performed a probabilistic object reversal task (pORT) along with a battery of tests assessing executive functions and general intellectual abilities. The pORT requires learning and reversing associations between actions and their outcomes. Older participants collected fewer points, needed more trials to reach the learning criterion, and completed less blocks successfully compared to young adults. This difference remained statistically significant after correcting for the age effect of other tests assessing executive functions. This suggests that there is an age-related difference in reward association learning as measured using the pORT, which is not closely related to other executive functions with respect to the age effect. In human aging, structural alterations of reward detecting structures and functional changes of the dopaminergic as well as the serotonergic system might contribute to the deficit in reward association learning observed in this study. (C) 2004 Elsevier Ltd. All rights reserved
Y1  - 2005
SN  - 0028-3932
ER  - 
TY  - JOUR
A1  - Marschner, Alexander
A1  - Mell, Thomas
A1  - Wartenburger, Isabell
A1  - Villringer, Arno
A1  - Reischies, Friedel M.
A1  - Heekeren, Hauke R.
T1  - Reward-based decision-making and aging
Y1  - 2005
SN  - 0361-9230
ER  - 
TY  - JOUR
A1  - Koenig, Julian
A1  - Abler, Birgit
A1  - Agartz, Ingrid
A1  - akerstedt, Torbjorn
A1  - Andreassen, Ole A.
A1  - Anthony, Mia
A1  - Baer, Karl-Juergen
A1  - Bertsch, Katja
A1  - Brown, Rebecca C.
A1  - Brunner, Romuald
A1  - Carnevali, Luca
A1  - Critchley, Hugo D.
A1  - Cullen, Kathryn R.
A1  - de Geus, Eco J. C.
A1  - de la Cruz, Feliberto
A1  - Dziobek, Isabel
A1  - Ferger, Marc D.
A1  - Fischer, Hakan
A1  - Flor, Herta
A1  - Gaebler, Michael
A1  - Gianaros, Peter J.
A1  - Giummarra, Melita J.
A1  - Greening, Steven G.
A1  - Guendelman, Simon
A1  - Heathers, James A. J.
A1  - Herpertz, Sabine C.
A1  - Hu, Mandy X.
A1  - Jentschke, Sebastian
A1  - Kaess, Michael
A1  - Kaufmann, Tobias
A1  - Klimes-Dougan, Bonnie
A1  - Koelsch, Stefan
A1  - Krauch, Marlene
A1  - Kumral, Deniz
A1  - Lamers, Femke
A1  - Lee, Tae-Ho
A1  - Lekander, Mats
A1  - Lin, Feng
A1  - Lotze, Martin
A1  - Makovac, Elena
A1  - Mancini, Matteo
A1  - Mancke, Falk
A1  - Mansson, Kristoffer N. T.
A1  - Manuck, Stephen B.
A1  - Mather, Mara
A1  - Meeten, Frances
A1  - Min, Jungwon
A1  - Mueller, Bryon
A1  - Muench, Vera
A1  - Nees, Frauke
A1  - Nga, Lin
A1  - Nilsonne, Gustav
A1  - Ordonez Acuna, Daniela
A1  - Osnes, Berge
A1  - Ottaviani, Cristina
A1  - Penninx, Brenda W. J. H.
A1  - Ponzio, Allison
A1  - Poudel, Govinda R.
A1  - Reinelt, Janis
A1  - Ren, Ping
A1  - Sakaki, Michiko
A1  - Schumann, Andy
A1  - Sorensen, Lin
A1  - Specht, Karsten
A1  - Straub, Joana
A1  - Tamm, Sandra
A1  - Thai, Michelle
A1  - Thayer, Julian F.
A1  - Ubani, Benjamin
A1  - van Der Mee, Denise J.
A1  - van Velzen, Laura S.
A1  - Ventura-Bort, Carlos
A1  - Villringer, Arno
A1  - Watson, David R.
A1  - Wei, Luqing
A1  - Wendt, Julia
A1  - Schreiner, Melinda Westlund
A1  - Westlye, Lars T.
A1  - Weymar, Mathias
A1  - Winkelmann, Tobias
A1  - Wu, Guo-Rong
A1  - Yoo, Hyun Joo
A1  - Quintana, Daniel S.
T1  - Cortical thickness and resting-state cardiac function across the lifespan
BT  - a cross-sectional pooled mega-analysis
JF  - Psychophysiology : journal of the Society for Psychophysiological Research
N2  - Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS-or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
KW  - aging
KW  - autonomic nervous system
KW  - cortical thickness
KW  - heart rate
KW  - heart
KW  - rate variability
KW  - sex
Y1  - 2020
U6  - https://doi.org/10.1111/psyp.13688
SN  - 0048-5772
SN  - 1469-8986
VL  - 58
IS  - 7
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Heekeren, Hauke R.
A1  - Wartenburger, Isabell
A1  - Schmidt, Helge
A1  - Schwintowski, Hans-Peter
A1  - Villringer, Arno
T1  - An fMRI study of simple ethical decision-making
Y1  - 2003
UR  - http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00001756-000000000- 00000.kc&LINKTYPE=asBody&LINKPOS=1&D=yrovft
SN  - 0959-4965
ER  - 
TY  - JOUR
A1  - Heekeren, Hauke R.
A1  - Wartenburger, Isabell
A1  - Schmidt, Helge
A1  - Prehn, Kristin
A1  - Schwintowski, Hans-Peter
A1  - Villringer, Arno
T1  - Influence of bodily harm on neural correlates of semantic and moral decision-making
N2  - Moral decision-making is central to everyday social life because the evaluation of the actions of another agent or our own actions made with respect to the norms and values guides our behavior in a community. There is previous evidence that the presence of bodily harm-even if irrelevant for a decision-may affect the decision-making, process. While recent neuroimaging studies found a common neural substrate of moral decision-making, the role of bodily harm has not been systematically studied so far. Here we used event-related functional magnetic resonance imaging (fMRI) to investigate how behavioral and neural correlates of semantic and moral decision-making processes are modulated by the presence of direct bodily harm or violence in the stimuli. Twelve participants made moral and semantic decisions about sentences describing actions of agents that either contained bodily harm or not and that could easily be judged as being good or bad or correct/incorrect, respectively. During moral and semantic decision-making, the presence of bodily harm resulted in faster response times (RT) and weaker activity in the temporal poles relative to trials devoid of bodily harm/violence, indicating a processing advantage and reduced processing depth for violence-related linguistic stimuli. Notably, there was no increase in activity in the amygdala and the posterior cingulate cortex (PCC) in response to trials containing bodily harm. These findings might be a correlate of limited generation of the semantic and emotional context in the anterior temporal poles during the evaluation of actions of another agent related to violence that is made with respect to the norms and values guiding our behavior in a community. (C) 2004 Elsevier Inc. All rights reserved
Y1  - 2005
SN  - 1053-8119
ER  - 
TY  - JOUR
A1  - Heekeren, Hauke R.
A1  - Wartenburger, Isabell
A1  - Marschner, Alexander
A1  - Mell, Thomas
A1  - Villringer, Arno
A1  - Reischies, Friedel M.
T1  - Role of ventral striatum in reward-based decision making
Y1  - 2007
SN  - 0959-4965
ER  - 
TY  - JOUR
A1  - Cannestra, Andrew F.
A1  - Wartenburger, Isabell
A1  - Obrig, Hellmuth
A1  - Villringer, Arno
A1  - Toga, Arthur W.
T1  - Functional assessment of Broca's area using near infrared spectroscopy in humans
Y1  - 2003
UR  - http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00001756-000000000- 00000.kc&LINKTYPE=asBody&LINKPOS=1&D=yrovft
SN  - 0959-4965
ER  -