TY - GEN
A1 - Wippert, Pia-Maria
A1 - Block, Andrea
A1 - Mansuy, Isabelle M.
A1 - Peters, Eva M. J.
A1 - Rose, Matthias
A1 - Rapp, Michael A.
A1 - Huppertz, Alexander
A1 - Würtz-Kozak, Karin
T1 - Alterations in Bone Homeostasis and Microstructure Related to Depression and Allostatic Load
T2 - Psychotherapy and Psychosomatics
Y1 - 2019
U6 - https://doi.org/10.1159/000503640
SN - 0033-3190
SN - 1423-0348
VL - 88
IS - 6
SP - 383
EP - 385
PB - Karger
CY - Basel
ER -
TY - JOUR
A1 - Schomöller, Anne
A1 - Risch, Lucie
A1 - Kaplick, Hannes
A1 - Wochatz, Monique
A1 - Engel, Tilman
A1 - Schraplau, Anne
A1 - Sonnenburg, Dominik
A1 - Huppertz, Alexander
A1 - Mayer, Frank
T1 - Inter-rater and inter-session reliability of lumbar paraspinal muscle composition in a mobile MRI device
JF - BJR : an international journal of radiology, radiation oncology and all related sciences / British Institute of Radiology
N2 - Objective: To assess the reliability of measurements of paraspinal muscle transverse relaxation times (T2 times) between two observers and within one observer on different time points.
Methods: 14 participants (9f/5m, 33 +/- 5 years, 176 +/- 10 cm, 73 +/- 12 kg) underwent 2 consecutive MRI scans (M1,M2) on the same day, followed by 1 MRI scan 13-14 days later (M3) in a mobile 1.5 Tesla MRI. T2 times were calculated in T-2 weighted turbo spin- echo-sequences at the spinal level of the third lumbar vertebrae (11 slices, 2 mm slice thickness, 1 mm interslice gap, echo times: 20, 40, 60, 80, 100 ms) for M. erector spinae (ES) and M. multifidius (MF). The following reliability parameter were calculated for the agreement of T2 times between two different investigators (OBS1 & OBS2) on the same MRI (inter rater reliability, IR) and by one investigator between different MRI of the same participant (intersession variability, IS): Test-Retest Variability (TRV, Differences/Mean*100); Coefficient of Variation (CV, Standard deviation/Mean*100); Bland-Altman Analysis (systematic bias = Mean of the Differences; Upper/Lower Limits of Agreement = Bias+/-1.96*SD); Intraclass Correlation Coefficient 3.1 (ICC) with absolute agreement, as well as its 95% confidence interval.
Results: Mean TRV for IR was 2.6% for ES and 4.2% for MF. Mean TRV for IS was 3.5% (ES) and 5.1% (MF). Mean CV for IR was 1.9 (ES) and 3.0 (MF). Mean CV for IS was 2.5% (ES) and 3.6% (MF). A systematic bias of 1.3 ms (ES) and 2.1 ms (MF) were detected for IR and a systematic bias of 0.4 ms (ES) and 0.07 ms (MF) for IS. ICC for IR was 0.94 (ES) and 0.87 (MF). ICC for IS was 0.88 (ES) and 0.82 (MF).
Conclusion: Reliable assessment of paraspinal muscle T2 time justifies its use for scientific purposes. The applied technique could be recommended to use for future studies that aim to assess changes of T2 times, e.g. after an intense bout of eccentric exercises.
Y1 - 2021
U6 - https://doi.org/10.1259/bjr.20210141
SN - 0007-1285
SN - 1748-880X
VL - 94
IS - 1127
PB - Wiley
CY - Bognor Regis
ER -
TY - JOUR
A1 - Boldt, Julia
A1 - Leber, Alexander W.
A1 - Bonaventura, Klaus
A1 - Sohns, Christian
A1 - Stula, Martin
A1 - Huppertz, Alexander
A1 - Haverkamp, Wilhelm
A1 - Dorenkamp, Marc
T1 - Cost-effectiveness of cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary artery disease in Germany
JF - Journal of cardiovascular magnetic resonance
N2 - Background: Recent studies have demonstrated a superior diagnostic accuracy of cardiovascular magnetic resonance (CMR) for the detection of coronary artery disease (CAD). We aimed to determine the comparative cost-effectiveness of CMR versus single-photon emission computed tomography (SPECT).
Methods: Based on Bayes' theorem, a mathematical model was developed to compare the cost-effectiveness and utility of CMR with SPECT in patients with suspected CAD. Invasive coronary angiography served as the standard of reference. Effectiveness was defined as the accurate detection of CAD, and utility as the number of quality-adjusted life-years (QALYs) gained. Model input parameters were derived from the literature, and the cost analysis was conducted from a German health care payer's perspective. Extensive sensitivity analyses were performed.
Results: Reimbursement fees represented only a minor fraction of the total costs incurred by a diagnostic strategy. Increases in the prevalence of CAD were generally associated with improved cost-effectiveness and decreased costs per utility unit (Delta QALY). By comparison, CMR was consistently more cost-effective than SPECT, and showed lower costs per QALY gained. Given a CAD prevalence of 0.50, CMR was associated with total costs of (sic)6,120 for one patient correctly diagnosed as having CAD and with (sic)2,246 per Delta QALY gained versus (sic)7,065 and (sic)2,931 for SPECT, respectively. Above a threshold value of CAD prevalence of 0.60, proceeding directly to invasive angiography was the most cost-effective approach.
Conclusions: In patients with low to intermediate CAD probabilities, CMR is more cost-effective than SPECT. Moreover, lower costs per utility unit indicate a superior clinical utility of CMR.
KW - Cost-effectiveness
KW - Cardiovascular magnetic resonance
KW - Scintigraphy
KW - Coronary angiography
KW - Coronary artery disease
Y1 - 2013
U6 - https://doi.org/10.1186/1532-429X-15-30
SN - 1097-6647
VL - 15
IS - 30
PB - BioMed Central
CY - London
ER -
TY - GEN
A1 - Boldt, Julia
A1 - Leber, Alexander W.
A1 - Bonaventura, Klaus
A1 - Sohns, Christian
A1 - Stula, Martin
A1 - Huppertz, Alexander
A1 - Haverkamp, Wilhelm
A1 - Dorenkamp, Marc
T1 - Cost-effectiveness of cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary artery disease in Germany
T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe
N2 - Background: Recent studies have demonstrated a superior diagnostic accuracy of cardiovascular magnetic resonance (CMR) for the detection of coronary artery disease (CAD). We aimed to determine the comparative cost-effectiveness of CMR versus single-photon emission computed tomography (SPECT).
Methods: Based on Bayes' theorem, a mathematical model was developed to compare the cost-effectiveness and utility of CMR with SPECT in patients with suspected CAD. Invasive coronary angiography served as the standard of reference. Effectiveness was defined as the accurate detection of CAD, and utility as the number of quality-adjusted life-years (QALYs) gained. Model input parameters were derived from the literature, and the cost analysis was conducted from a German health care payer's perspective. Extensive sensitivity analyses were performed.
Results: Reimbursement fees represented only a minor fraction of the total costs incurred by a diagnostic strategy. Increases in the prevalence of CAD were generally associated with improved cost-effectiveness and decreased costs per utility unit (Delta QALY). By comparison, CMR was consistently more cost-effective than SPECT, and showed lower costs per QALY gained. Given a CAD prevalence of 0.50, CMR was associated with total costs of (sic)6,120 for one patient correctly diagnosed as having CAD and with (sic)2,246 per Delta QALY gained versus (sic)7,065 and (sic)2,931 for SPECT, respectively. Above a threshold value of CAD prevalence of 0.60, proceeding directly to invasive angiography was the most cost-effective approach.
Conclusions: In patients with low to intermediate CAD probabilities, CMR is more cost-effective than SPECT. Moreover, lower costs per utility unit indicate a superior clinical utility of CMR.
T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 551
KW - cost-effectiveness
KW - cardiovascular magnetic resonance
KW - scintigraphy
KW - coronary angiography
KW - coronary artery disease
Y1 - 2019
U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-430107
SN - 1866-8364
IS - 551
ER -