TY  - JOUR
A1  - Fiehler, Katja
A1  - Bannert, Michael M.
A1  - Bischoff, Matthias
A1  - Blecker, Carlo
A1  - Stark, Rudolf
A1  - Vaitl, Dieter
A1  - Franz, Volker H.
A1  - Roesler, Frank
T1  - Working memory maintenance of grasp-target information in the human posterior parietal cortex
JF  - NeuroImage : a journal of brain function
N2  - Event-related functional magnetic resonance imaging was applied to identify cortical areas involved in maintaining target information in working memory used for an upcoming grasping action. Participants had to grasp with their thumb and index finger of the dominant right hand three-dimensional objects of different size and orientation. Reaching-to-grasp movements were performed without visual feedback either immediately after object presentation or after a variable delay of 2-12 s. The right inferior parietal cortex demonstrated sustained neural activity throughout the delay, which overlapped with activity observed during encoding of the grasp target. Immediate and delayed grasping activated similar motor-related brain areas and showed no differential activity. The results suggest that the right inferior parietal cortex plays an important functional role in working memory maintenance of grasp-related information. Moreover, our findings confirm the assumption that brain areas engaged in maintaining information are also involved in encoding the same information, and thus extend previous findings on working memory function of the posterior parietal cortex in saccadic behavior to reach-to-grasp movements.
Y1  - 2011
U6  - https://doi.org/10.1016/j.neuroimage.2010.09.080
SN  - 1053-8119
VL  - 54
IS  - 3
SP  - 2401
EP  - 2411
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Khader, Patrick H.
A1  - Pachur, Thorsten
A1  - Meier, Stefanie
A1  - Bien, Siegfried
A1  - Jost, Kerstin
A1  - Roesler, Frank
T1  - Memory-based decision-making with heuristics evidence for a controlled activation of memory representations
JF  - Journal of cognitive neuroscience
N2  - Many of our daily decisions are memory based, that is, the attribute information about the decision alternatives has to be recalled. Behavioral studies suggest that for such decisions we often use simple strategies (heuristics) that rely on controlled and limited information search. It is assumed that these heuristics simplify decision-making by activating long-term memory representations of only those attributes that are necessary for the decision. However, from behavioral studies alone, it is unclear whether using heuristics is indeed associated with limited memory search. The present study tested this assumption by monitoring the activation of specific long-term-memory representations with fMRI while participants made memory-based decisions using the "take-the-best" heuristic. For different decision trials, different numbers and types of information had to be retrieved and processed. The attributes consisted of visual information known to be represented in different parts of the posterior cortex. We found that the amount of information required for a decision was mirrored by a parametric activation of the dorsolateral PFC. Such a parametric pattern was also observed in all posterior areas, suggesting that activation was not limited to those attributes required for a decision. However, the posterior increases were systematically modulated by the relative importance of the information for making a decision. These findings suggest that memory-based decision-making is mediated by the dorsolateral PFC, which selectively controls posterior storage areas. In addition, the systematic modulations of the posterior activations indicate a selective boosting of activation of decision-relevant attributes.
Y1  - 2011
SN  - 0898-929X
VL  - 23
IS  - 11
SP  - 3540
EP  - 3554
PB  - MIT Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Mikelskis, Helmut
A1  - Seifert, Silke
A1  - Roesler, Frank
T1  - Optik lernen mit der Simulationssoftware phenOpt
Y1  - 1999
SN  - 0025-5866
ER  -