TY  - JOUR
A1  - Perez-Velazquez, Jose Luis
A1  - Erra, Ramon Guevara
A1  - Rosenblum, Michael
T1  - The Epileptic Thalamocortical Network is a Macroscopic Self-Sustained Oscillator: Evidence from Frequency-Locking Experiments in Rat Brains
JF  - Scientific reports
N2  - The rhythmic activity observed in nervous systems, in particular in epilepsies and Parkinson's disease, has often been hypothesized to originate from a macroscopic self-sustained neural oscillator. However, this assumption has not been tested experimentally. Here we support this viewpoint with in vivo experiments in a rodent model of absence seizures, by demonstrating frequency locking to external periodic stimuli and finding the characteristic Arnold tongue. This result has important consequences for developing methods for the control of brain activity, such as seizure cancellation.
Y1  - 2015
U6  - https://doi.org/10.1038/srep08423
SN  - 2045-2322
VL  - 5
PB  - Nature Publ. Group
CY  - London
ER  -