TY  - GEN
A1  - Saberi Hosnijeh, Fatemeh
A1  - Casabonne, Delphine
A1  - Nieters, Alexandra
A1  - Solans, Marta
A1  - Naudin, Sabine
A1  - Ferrari, Pietro
A1  - Mckay, James D.
A1  - Benavente, Yolanda
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Severi, Gianluca
A1  - Boutron Ruault, Marie-Christine
A1  - Besson, Caroline
A1  - Agnoli, Claudia
A1  - Masala, Giovanna
A1  - Sacerdote, Carlotta
A1  - Tumino, Rosario
A1  - Huerta, Jose Maria
A1  - Amiano, Pilar
A1  - Rodriguez-Barranco, Miguel
A1  - Bonet, Catalina
A1  - Barricarte, Aurelio
A1  - Christakoudi, Sofia
A1  - Knuppel, Anika
A1  - Bueno-de-Mesquita, Bas
A1  - Schulze, Matthias B.
A1  - Kaaks, Rudolf
A1  - Canzian, Federico
A1  - Spath, Florentin
A1  - Jerkeman, Mats
A1  - Rylander, Charlotta
A1  - Tjonneland, Anne
A1  - Olsen, Anja
A1  - Borch, Kristin Benjaminsen
A1  - Vermeulen, Roel
T1  - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma
BT  - an exposome-wide analysis
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1374 
KW  - exposome
KW  - exposome‐ wide association study
KW  - lifestyle
KW  - lymphoma
KW  - prospective study
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-573562
SN  - 1866-8372
IS  - 9
ER  -