TY  - JOUR
A1  - Hanke-Gogokhia, Christin
A1  - Zhang, Houbin
A1  - Frederick, Jeanne M.
A1  - Baehr, Wolfgang
ED  - Rickman, CB
ED  - LaVail, MM
ED  - Anderson, RE
ED  - Grimm, C
ED  - Hollyfield, J
ED  - Ash, J
T1  - The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors
JF  - Retinal Degenerative Diseases : Mechanisms and Experimental Therapy
N2  - Arf-like proteins (ARLs) are ubiquitously expressed small G proteins of the RAS superfamily. In photoreceptors, ARL2 and ARL3 participate in the trafficking of lipidated membrane-associated proteins and colocalize in the inner segment with UNC119A and PDE delta. UNC119A and PDE delta are acyl-and prenyl-binding proteins, respectively, involved in trafficking of acylated (transducin-alpha subunit, nephrocystin NPHP3) and prenylated proteins (GRK1, PDE6). Germline Arl3 knockout mice do not survive beyond postnatal day 21 and display ciliary defects in multiple organs (kidney, liver and pancreas) as well as retinal degeneration. Conditional knockouts will be necessary to delineate mechanisms of protein transport in retina disease.
KW  - Arf-like protein 3 (ARL3)
KW  - Arf-like protein 2 (ARL2)
KW  - Phosphodiesterase delta-subunit (PDE delta)
KW  - unc-119 homolog (C. elegans) (UNC119A)
KW  - Retinitis pigmentosa protein 2 (RP2)
KW  - Rod photoreceptor
Y1  - 2016
SN  - 978-3-319-17121-0; 978-3-319-17120-3
U6  - https://doi.org/10.1007/978-3-319-17121-0_87
SN  - 0065-2598
VL  - 854
SP  - 655
EP  - 661
PB  - Springer International Publishing AG
CY  - Cham
ER  -