TY - JOUR A1 - Edlund, Helena A1 - Grisic, Ana-Marija A1 - Steenholdt, Casper A1 - Ainsworth, Mark Andrew A1 - Brynskov, Torn A1 - Huisinga, Wilhelm A1 - Kloft, Charlotte T1 - Absence of Relationship Between Crohn's Disease Activity Index or C-Reactive Protein and Infliximab Exposure Calls for Objective Crohn's Disease Activity Measures for the Evaluation of Treatment Effects at Treatment Failure JF - Therapeutic drug monitoring : official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology N2 - Background: Circulating infliximab (IFX) concentrations correlate with clinical outcomes, forming the basis of the IFX concentration monitoring in patients with Crohn's disease. This study aims to investigate and refine the exposure-response relationship by linking the disease activity markers "Crohn's disease activity index" (CDAI) and C-reactive protein (CRP) to IFX exposure. In addition, we aim to explore the correlations between different disease markers and exposure metrics. Methods: Data from 47 Crohn's disease patients of a randomized controlled trial were analyzed post hoc. All patients had secondary treatment failure at inclusion and had received intensified IFX of 5 mg/kg every 4 weeks for up to 20 weeks. Graphical analyses were performed to explore exposure-response relationships. Metrics of exposure included area under the concentration-time curve (AUC) and trough concentrations (Cmin). Disease activity was measured by CDAI and CRP values, their change from baseline/last visit, and response/remission outcomes at week 12. Results: Although trends toward lower Cmin and lower AUC in nonresponders were observed, neither CDAI nor CRP showed consistent trends of lower disease activity with higher IFX exposure across the 30 evaluated relationships. As can be expected, Cmin and AUC were strongly correlated with each other. Contrarily, the disease activity markers were only weakly correlated with each other. Conclusions: No significant relationship between disease activity, as evaluated by CDAI or CRP, and IFX exposure was identified. AUC did not add benefit compared with Cmin. These findings support the continued use of Cmin and call for stringent objective disease activity (bio-)markers (eg, endoscopy) to form the basis of personalized IFX therapy for Crohn's disease patients with IFX treatment failure. Y1 - 2019 U6 - https://doi.org/10.1097/FTD.0000000000000590 SN - 0163-4356 SN - 1536-3694 VL - 41 IS - 2 SP - 235 EP - 242 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - CHAP A1 - Grum, Marcus A1 - Rapp, Simon A1 - Gronau, Norbert A1 - Albers, Albert ED - Shishkov, Boris T1 - Accelerating knowledge BT - the speed optimization of knowledge transfers T2 - Business modeling and software design N2 - As knowledge-intensive processes are often carried out in teams and demand for knowledge transfers among various knowledge carriers, any optimization in regard to the acceleration of knowledge transfers obtains a great economic potential. Exemplified with product development projects, knowledge transfers focus on knowledge acquired in former situations and product generations. An adjustment in the manifestation of knowledge transfers in its concrete situation, here called intervention, therefore can directly be connected to the adequate speed optimization of knowledge-intensive process steps. This contribution presents the specification of seven concrete interventions following an intervention template. Further, it describes the design and results of a workshop with experts as a descriptive study. The workshop was used to assess the practical relevance of interventions designed as well as the identification of practical success factors and barriers of their implementation. KW - knowledge transfers KW - business process optimization KW - interventions KW - product development KW - product generation engineering KW - empirical evaluation Y1 - 2019 SN - 978-3-030-24853-6 SN - 978-3-030-24854-3 U6 - https://doi.org/10.1007/978-3-030-24854-3_7 VL - 356 SP - 95 EP - 113 PB - Springer CY - Cham ER - TY - THES A1 - Eckert, Sebastian T1 - Accessing active sites of molecular proton dynamics N2 - The unceasing impact of intense sunlight on earth constitutes a continuous source of energy fueling countless natural processes. On a molecular level, the energy contained in the electromagnetic radiation is transferred through photochemical processes into chemical or thermal energy. In the course of such processes, photo-excitations promote molecules into thermally inaccessible excited states. This induces adaptations of their molecular geometry according to the properties of the excited state. Decay processes towards energetically lower lying states in transient molecular geometries result in the formation of excited state relaxation pathways. The photo-chemical relaxation mechanisms depend on the studied system itself, the interactions with its chemical environment and the character of the involved states. This thesis focuses on systems in which photo-induced deprotonation processes occur at specific atomic sites. To detect these excited-state proton dynamics at the affected atoms, a local probe of molecular electronic structure is required. Therefore, site-selective and orbital-specific K-edge soft X-ray spectroscopy techniques are used here to detect photo-induced proton dynamics in gaseous and liquid sample environments. The protonation of nitrogen (N) sites in organic molecules and the oxygen (O) atom in the water molecule are probed locally through transitions between 1s orbitals and the p-derived molecular valence electronic structure. The used techniques are X-ray absorption spectroscopy (XAS) and resonant inelastic X-ray scattering (RIXS). Both yield access to the unoccupied local valence electronic structure, whereas the latter additionally probes occupied states. We apply these probes in optical pump X-ray probe experiments to investigate valence excited-state proton transfer capabilities of aqueous 2-thiopyridone. A characteristic shift of N K-edge X-ray absorption resonances as well as a distinct X-ray emission line are established by us as spectral fingerprints of N deprotonation in the system. We utilize them to identify photo-induced N deprotonation of 2-thiopyridone on femtosecond timescales, in optical pump N K-edge RIXS probe measurements. We further establish excited state proton transfer mechanisms on picosecond and nanosecond timescales along the dominant relaxation pathways of 2-thiopyridone using transient N K-edge XAS. Despite being an excellent probe mechanism for valence excited-state proton dynamics, the K-edge core-excitation itself also disturbs the electronic structure at specific sites of a molecule. The rapid reaction of protons to 1s photo-excitations can yield directional structural distortions within the femtosecond core-excited state lifetime. These directional proton dynamics can change the energetic separation of eigenstates of the system and alter probabilities for radiative decay between them. Both effects yield spectral signatures of the dynamics in RIXS spectra. Using these signatures of RIXS transitions into electronically excited states, we investigate proton dynamics induced by N K-edge excitation in the amino-acid histidine. The minor core-excited state dynamics of histidine in basic and neutral chemical environments allow us to establish XAS and RIXS spectral signatures of different N protonation states at its imidazole N sites. Based on these signatures, we identify an excitation-site-independent N-H dissociation for N K-edge excitation under acidic conditions. Such directional structural deformations, induced by core-excitations, also make proton dynamics in electronic ground states accessible through RIXS transitions into vibrationally excited states. In that context, we interpret high resolution RIXS spectra of the water molecule for three O K-edge resonances based on quantum-chemical wave packet propagation simulations. We show that highly oriented ground state vibrational modes of coupled nuclear motion can be populated through RIXS processes by preparation of core-excited state nuclear wave packets with the same directionality. Based on that, we analytically derive the possibility to extract one-dimensional directional cuts through potential energy surfaces of molecular systems from the corresponding RIXS spectra. We further verify this concept through the extraction of the gas-phase water ground state potential along three coordinates from experimental data in comparison to quantum-chemical simulations of the potential energy surface. This thesis also contains contributions to instrumentation development for investigations of photo-induced molecular dynamics at high brilliance X-ray light sources. We characterize the setup used for the transient valence-excited state XAS measurements of 2-thiopyridone. Therein, a sub-micrometer thin liquid sample environment is established employing in-vacuum flat-jet technology, which enables a transmission experimental geometry. In combination with a MHz-laser system, we achieve a high detection sensitivity for photo-induced X-ray absorption changes. Additionally, we present conceptual improvements for temporal X-ray optical cross-correlation techniques based on transient changes of multilayer optical properties, which are crucial for the realization of femtosecond time-resolved studies at synchrotrons and free-electron lasers. N2 - Die stetige Bestrahlung der Erde mit intensivem Sonnenlicht stellt einen permanente Energiequelle dar, die zahllose natürliche Prozesse antreibt. Auf molekularer Ebene wird die Energie der elektromagnetischen Strahlung durch photochemische Prozesse in chemische und thermische Energie umgewandelt. Während dieser Prozesse werden thermisch nicht erreichbare angeregte Zustände von Molekülen durch Photoanregungen bevölkert. Dies führt zu Änderungen der Molekülgeometrie, die abhängig von den Eigenschaften der angeregten Zustände sind. Zerfallsprozesse in energetisch tieferliegende Zustände in transienten Molekülgeometrien führen zur Ausbildung von Relaxationspfaden angeregter Zustände. Die Relaxationsmechanismen sind dabei abhängig vom untersuchten System selbst, den Wechselwirkungen mit seiner chemischen Umgebung und den Eigenschaften der beteiligten angeregten Zustände. In dieser Arbeit werden Systeme untersucht, in denen die Protonierung bestimmter Atome im Molekül durch eine Photoanregung geändert werden kann. Um Protonendynamik an den betreffenden Atomen zu untersuchen, wird ein lokaler Zugang zur elektronischen Struktur des Moleküls benötigt. Daher wird in dieser Arbeit K-Kanten Weichröntgenspektroskopie genutzt, um photo-induzierte Protonendynamik in gasförmigen und flüssigen Proben zu untersuchen. Zusätzlich zur Selektivität bzgl. des Elements und des chemischen Zustands des betreffenden Atoms bietet diese Zugang zum Charakter und zur Lokalisierung der bindungsformenden Valenzorbitale. Die Protonierung von Stickstoffatomen (N) in organischen Systemen und die des Sauerstoffatoms (O) im Wassermolekül wird dabei durch Übergänge zwischen stark lokalisierten 1s- und Valenzorbitalen mit 2p-Charakter detektiert. Die verwendeten Spektroskopiemethoden Röntgenabsorption (engl. X-ray absorption spectroscopy, XAS) und resonate inelastische Röntgenstreuung (engl. resonant inelastic X-ray scattering, RIXS) bieten dabei einen lokalen Zugang zur unbesetzten bzw. im Fall von RIXS auch zur besetzten elektronischen Struktur der untersuchten Moleküle. Mit Hilfe der genannten Methoden haben wir in zeitaufgelösten Anrege-Abfrage (engl. pump-probe) Experimenten durch Valenzanregungen induzierte Protonentransfer-Prozesse (engl. excited state proton transfer, ESPT) des Moleküls 2-Thiopyridon in wässriger Lösung untersucht. Eine Verschiebung der N K-Kanten Röntgenabsorptionsresonanzen, sowie eine charakteristische Röntgenemissionslinie werden von uns als spektrale Signaturen einer N Deprotonierung des Systems etabliert. Eine potenzielle photo-induzierte N Deprotonierung des Moleküls wird anhand dieser Signaturen auf femtosekunden Zeitskalen über zeitaufgelöste N K-Kanten RIXS Messungen identifiziert. Protonentransfer-Mechanismen auf Pico- und Nanosekunden Zeitskalen entlang der dominanten Relaxationspfade des Systems werden mit zeitaufgelöstem N K-Kanten XAS untersucht. K-Kanten Rumpfanregungen eignen sich nicht nur ideal zur Detektion von Protonendynamik in valenzangeregten Zuständen, da die Rumpfanregungen selbst auch eine lokalisierte Störung der elektronischen Struktur darstellen. Vor allem die Reaktion von Protonen auf diese Störung innerhalb der 1s Rumpfloch-Lebensdauer von wenigen Femtosekunden kann zu einer gerichteten Verzerrung der Molekülstruktur führen. Die damit verbundenen Änderungen von Übergangsenergien und -wahrscheinlichkeiten sind als Signaturen dieser gerichteten Protonendynamik in RIXS Spektren zugänglich. Anhand von RIXS Übergängen in elektronisch angeregte Zustände untersuchen wir Protonendynamik, die durch N K-Kanten Anregungen an den N Atomen im Imidazolring der Aminosäure Histidin induziert wird. Die schwache Dynamik in basischen und neutralen wässrigen Lösungen erlauben es uns, die Protonierung dieser N Atome mit charakteristischen spektralen Signaturen zu korrelieren. Mit Hilfe dieser Signaturen identifizieren wir eine durch K-Kanten Anregung verursachte N-H Dissoziation in saurer Lösung. Dieser Prozess ist unabhängig davon, an welchem der N Atome des Imidazolrings die Rumpfanregung lokalisiert ist. Solche, durch Rumpfanregungen verursachten, gerichteten Verzerrungen der Molekülstruktur ermöglichen einen Zugang zu Protonendynamik im elektronischen Grundzustand über RIXS Prozesse in dessen vibrationsangeregte Zustände. In diesem Zusammenhang vergleichen wir hochaufgelöste O K-Kanten RIXS Spektren des Wassermoleküls in der Gasphase mit quantenchemischen Simulationen zur Wellenpaketpropagation in den rumpfangeregten Zuständen. Dabei wird deutlich, dass die gerichtete Verzerrung der Molekülstruktur im rumpfangeregten Zustand eine Bevölkerung von Vibrationsmoden des Grundzustandes mit der gleichen Ausrichtung durch den RIXS Prozess verursacht. Anhand dieser Ergebnisse leiten wir ab, unter welchen Bedingungen eine Extraktion eindimensionaler Querschnitte der Potentialfläche des Grundzustandes aus den entsprechenden RIXS Spektren möglich ist. Wir verifizieren diese Methode anhand der Extraktion der Grundzustandspotentialfläche des Wassermoleküls entlang drei unterschiedlicher Richtungen im Vergleich zu den quantenchemischen Rechnungen. Diese Arbeit enthält zudem Beiträge zur Entwicklung von Instrumentierung für Untersuchungen valenzangeregter Moleküldynamik an Röntgenquellen mit hoher Brillianz. Der experimentelle Aufbau, der für die zeitaufgelösten XAS Messungen an 2-Thiopyridon verwendet wurde, wird vorgestellt. Ein sub-Mikrometer dünner Flüssigkeitsflachstrahl erlaubt dabei Messungen in einer Transmissionsgeometrie. In Kombination mit einem MHz-Lasersystem können transiente Absorptionsänderungen effizient detektiert werden. Zudem präsentieren wir Konzepte zur zeitlichen Korrelation von Röntgen- und optischen Lichtpulsen, basierend auf Änderungen der optischen Eigenschaften von Dünnschichtsystemen, die essenziell für Studien transienter Prozesse an Synchrotrons und Freie-Elektronen Lasern mit Femtosekunden Zeitauflösung sind. KW - molecular proton dynamics KW - Protonendynamik molekularer Systeme KW - K-edge soft X-ray spectroscopy KW - K-Kanten Weichröntgenspektroskopie KW - excited state proton transfer KW - Protonentransfer in angeregten Zuständen KW - core-excited state dynamics KW - Dynamik in rumpfangeregten Zuständen KW - optical pump - X-ray probe spectroscopy KW - Kurzzeitspektroskopie mit optischer Anregung und Röntgendetektion Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-425870 ER - TY - JOUR A1 - Gefen-Treves, Shany A1 - Kedem, Isaac A1 - Weiss, Gad A1 - Wagner, Dirk A1 - Tchernov, Dan A1 - Kaplan, Aaron T1 - Acclimation of a rocky shore algal reef builder Neogoniolithon sp. to changing illuminations JF - Limnology and oceanography e-lectures / Association for the Sciences of Limnology and Oceanography N2 - Vermetid reefs and rocky shores are hot spots of biodiversity, often referred to as the subtropical equivalent of coral reefs. The development of the ecosystem depends on the activity of several reef builders, including red crustose coralline algae (CCA) such as Neogoniolithon brassica-florida. Despite its importance, little is known about Neogoniolithon sp. acclimation to rapid changes in light intensity and corresponding photosynthetic activity. To overcome the large spatial variability in the light field (due to location and the porous nature of the rocks) we grew Neogoniolithon sp. on glass slides and characterized its photosynthetic performance in response to various light intensities by following O-2 exchange and fluorescence parameters. This was also performed on rock-inhabiting thalli collected from the east Mediterranean basin. Generally, maximal photosynthetic rate was reached when Neogoniolithon sp. thalli grown under low illumination (such as in protected niches where the light intensity can be as low as 1% of surface illumination) were examined. When exposed to light intensities higher than those experienced during growth, Neogoniolithon sp. activates adaptive/protective mechanisms such as state transition and nonphotochemical fluorescence quenching and increases the dark respiration thereafter. We find that the Fv/Fm parameter (variable/maximal fluorescence) is not suitable to assess photosynthetic performance in Neogoniolithon sp. and propose using instead an alternative parameter recently developed. Our findings help to clarify why Neogoniolithon sp. is usually observed in shaded niches along the reef surfaces. Y1 - 2019 U6 - https://doi.org/10.1002/lno.11245 SN - 0024-3590 SN - 1939-5590 VL - 65 IS - 1 SP - 27 EP - 36 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Titov, Elena T1 - Accusative Unaccusatives BT - Of trees and birds. A Festschrift for Gisbert Fanselow KW - Festschrift KW - Informationsstruktur KW - Linguistik KW - Morphologie KW - Syntax KW - festschrift KW - information structure KW - linguistics KW - morphology KW - syntax Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432515 SN - 978-3-86956-457-9 SP - 243 EP - 256 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Yousfi, Alaaeddine A1 - Batoulis, Kimon A1 - Weske, Mathias T1 - Achieving Business Process Improvement via Ubiquitous Decision-Aware Business Processes JF - ACM Transactions on Internet Technology N2 - Business process improvement is an endless challenge for many organizations. As long as there is a process, it must he improved. Nowadays, improvement initiatives are driven by professionals. This is no longer practical because people cannot perceive the enormous data of current business environments. Here, we introduce ubiquitous decision-aware business processes. They pervade the physical space, analyze the ever-changing environments, and make decisions accordingly. We explain how they can be built and used for improvement. Our approach can be a valuable improvement option to alleviate the workload of participants by helping focus on the crucial rather than the menial tasks. KW - Business process improvement KW - ubiquitous decision-aware business process KW - ubiquitous decisions KW - context KW - uBPMN KW - DMN Y1 - 2019 U6 - https://doi.org/10.1145/3298986 SN - 1533-5399 SN - 1557-6051 VL - 19 IS - 1 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Cassel, Michael A1 - Risch, Lucie A1 - Mayer, Frank A1 - Kaplick, Hannes A1 - Engel, Aaron A1 - Kulig, Kornelia A1 - Bashford, Greg T1 - Achilles tendon morphology assessed using image based spatial frequency analysis is altered among healthy elite adolescent athletes compared to recreationally active controls JF - Journal of science and medicine in sport : official journal of Sports Medicine Australia N2 - Objectives: Although expected, tendon adaptations in adolescent elite athletes have been underreported. Morphologically, adaptations may occur by an increase in collagen fiber density and/or organization. These characteristics can be captured using spatial frequency parameters extracted from ultrasound images. This study aims to compare Achilles tendon (AT) morphology among sports-specific cohorts of elite adolescent athletes and to compare these findings to recreationally active controls by use of spatial frequency analysis. Design: Cross-sectional observational study. Method: In total, 334 healthy adolescent athletes from four sport categories (ball, combat, endurance, explosive strength) and 35 healthy controls were included. Longitudinal ultrasound scans were performed at the AT insertion and midportion. Intra-tendinous-morphology was quantified by performing spatial frequency analysis assessing eight parameters at standardized ROls. Increased values in five parameters suggest a higher structural organization, and in two parameters higher fiber density. One parameter represents a quotient combining both organization and fiber density. Results: Among athletes, only ball sport athletes exhibited an increase in one summative parameter at pre-insertion site compared to athletes from other sport categories. When compared to athletes, controls had significantly higher values of four parameters at pre-insertion and three parameters at midportion site reflecting differences in both, fiber organization and density. Conclusions: Intra-tendinous-morphology was similar in all groups of adolescent athletes. Higher values found in non-athletes might suggest higher AT fiber density and organization. It is yet unclear whether the lesser structural organization in young athletes represents initial AT pathology, or a physiological adaptive response at the fiber cross-linking level. (C) 2019 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved. KW - Tendon structure KW - Adaptation KW - Ultrasound KW - Athletic loading KW - Tendinopathy Y1 - 2019 U6 - https://doi.org/10.1016/j.jsams.2019.03.011 SN - 1440-2440 SN - 1878-1861 VL - 22 IS - 8 SP - 882 EP - 886 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Zeitler, Stefanie A1 - Ye, Lian A1 - Andreyeva, Aksana A1 - Schumacher, Fabian A1 - Monti, Juliana A1 - Nürnberg, Bernd A1 - Nowak, Gabriel A1 - Kleuser, Burkhard A1 - Reichel, Martin A1 - Fejtova, Anna A1 - Kornhuber, Johannes A1 - Rhein, Cosima A1 - Friedland, Kristina T1 - Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity JF - Journal of neurochemistry N2 - Recent investigations propose the acid sphingomyelinase (ASM)/ceramide system as a novel target for antidepressant action. ASM catalyzes the breakdown of the abundant membrane lipid sphingomyelin to the lipid messenger ceramide. This ASM‐induced lipid modification induces a local shift in membrane properties, which influences receptor clustering and downstream signaling. Canonical transient receptor potential channels 6 (TRPC6) are non‐selective cation channels located in the cell membrane that play an important role in dendritic growth, synaptic plasticity and cognition in the brain. They can be activated by hyperforin, an ingredient of the herbal remedy St. John’s wort for treatment of depression disorders. Because of their role in the context of major depression, we investigated the crosstalk between the ASM/ceramide system and TRPC6 ion channels in a pheochromocytoma cell line 12 neuronal cell model (PC12 rat pheochromocytoma cell line). Ca2+ imaging experiments indicated that hyperforin‐induced Ca2+ influx through TRPC6 channels is modulated by ASM activity. While antidepressants, known as functional inhibitors of ASM activity, reduced TRPC6‐mediated Ca2+ influx, extracellular application of bacterial sphingomyelinase rebalanced TRPC6 activity in a concentration‐related way. This effect was confirmed in whole‐cell patch clamp electrophysiology recordings. Lipidomic analyses revealed a decrease in very long chain ceramide/sphingomyelin molar ratio after ASM inhibition, which was connected with changes in the abundance of TRPC6 channels in flotillin‐1–positive lipid rafts as visualized by western blotting. Our data provide evidence that the ASM/ceramide system regulates TRPC6 channels likely by controlling their recruitment to specific lipid subdomains and thereby fine‐tuning their physical properties. KW - acid sphingomyelinase KW - antidepressants KW - ceramide KW - hyperforin KW - lipid rafts KW - TRPC6 Y1 - 2019 U6 - https://doi.org/10.1111/jnc.14823 SN - 0022-3042 SN - 1471-4159 VL - 150 IS - 6 SP - 678 EP - 690 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Beckmann, Nadine A1 - Becker, Katrin Anne A1 - Kadow, Stephanie A1 - Schumacher, Fabian A1 - Kramer, Melanie A1 - Kühn, Claudine A1 - Schulz-Schaeffer, Walter J. A1 - Edwards, Michael J. A1 - Kleuser, Burkhard A1 - Gulbins, Erich A1 - Carpinteiro, Alexander T1 - Acid sphingomyelinase deficiency ameliorates Farber disease T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can’t achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1087 KW - Farber disease KW - lysosomal storage disorders KW - acid ceramidase KW - acid sphingomyelinase KW - amitriptyline Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441282 SN - 1866-8372 IS - 1087 ER - TY - JOUR A1 - Beckmann, Nadine A1 - Becker, Katrin Anne A1 - Kadow, Stephanie A1 - Schumacher, Fabian A1 - Kramer, Melanie A1 - Kuehn, Claudine A1 - Schulz-Schaeffer, Walter J. A1 - Edwards, Michael J. A1 - Kleuser, Burkhard A1 - Gulbins, Erich A1 - Carpinteiro, Alexander T1 - Acid Sphingomyelinase Deficiency Ameliorates Farber Disease JF - International journal of molecular sciences N2 - Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can’t achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients. KW - Farber disease KW - lysosomal storage disorders KW - acid ceramidase KW - acid sphingomyelinase KW - amitriptyline Y1 - 2019 U6 - https://doi.org/10.3390/ijms20246253 SN - 1422-0067 VL - 20 IS - 24 PB - MDPI CY - Basel ER - TY - JOUR A1 - Andrés-Delgado, Laura A1 - Ernst, Alexander A1 - Galardi-Castilla, María A1 - Bazaga, David A1 - Peralta, Marina A1 - Münch, Juliane A1 - Gonzalez-Rosa, Juan M. A1 - Marques, Inês A1 - Tessadori, Federico A1 - de la Pompa, José Luis A1 - Vermot, Julien A1 - Mercader, Nadia T1 - Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells JF - Development : Company of Biologists N2 - The epicardium, the outer mesothelial layer enclosing the myocardium, plays key roles in heart development and regeneration. During embryogenesis, the epicardium arises from the proepicardium (PE), a cell cluster that appears in the dorsal pericardium (DP) close to the venous pole of the heart. Little is known about how the PE emerges from the pericardial mesothelium. Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables PE cells to extrude apically. We provide evidence that cell extrusion, which has been described in the elimination of unfit cells from epithelia and the emergence of hematopoietic stem cells, is also a mechanism for PE cells to exit an organized mesothelium and fulfil their developmental fate to form a new tissue layer, the epicardium. KW - Actomyosin KW - Bmp KW - Cell extrusion KW - Proepicardium KW - Zebrafish KW - Heart development Y1 - 2019 U6 - https://doi.org/10.1242/dev.174961 SN - 0950-1991 SN - 1477-9129 VL - 146 IS - 13 PB - The Company of Biologists Ltd CY - Cambridge ER - TY - THES A1 - Adam, Maurits T1 - Action-goal predictions in infancy BT - The influence of agency cues and verbal information Y1 - 2019 ER - TY - JOUR A1 - Zinke, Fridolin A1 - Gebel, Arnd A1 - Granacher, Urs A1 - Prieske, Olaf T1 - Acute Effects of Short-Term Local Tendon Vibration on Plantar Flexor Torque, Muscle Contractile Properties, Neuromuscular and Brain Activity in Young Athletes JF - Journal of sports science & medicine N2 - The purpose of this study was to examine the acute effects of short-term Achilles tendon vibration on plantar flexor torque, twitch contractile properties as well as muscle and cortical activity in young athletes. Eleven female elite soccer players aged 15.6 +/- 0.5 years participated in this study. Three different conditions were applied in randomized order: Achilles tendon vibration (80 Hz) for 30 and 300 s, and a passive control condition (300 s). Tests at baseline and following conditions included the assessment of peak plantar flexor torque during maximum voluntary contraction, electrically evoked muscle twitches (e.g., potentiated twitch peak torque [PT]), and electromyographic (EMG) activity of the plantar flexors. Additionally, electroencephalographic (EEG) activity of the primary motor and somatosensory cortex were assessed during a submaximal dynamic concentric-eccentric plantar flexion exercise using an elastic rubber band. Large-sized main effects of condition were found for EEG absolute alpha-1 and beta-1 band power (p <= 0.011; 1.5 <= d <= 2.6). Post-hoc tests indicated that alpha-1 power was significantly lower at 30 and 300 s (p = 0.009; d = 0.8) and beta-1 power significantly lower at 300 s (p < 0.001; d = 0.2) compared to control condition. No significant effect of condition was found for peak plantar flexor torque, electrical evoked muscle twitches, and EMG activity. In conclusion, short-term local Achilles tendon vibration induced lower brain activity (i.e., alpha-1 and beta-1 band power) but did not affect lower limb peak torque, twitch contractile properties, and muscle activity. Lower brain activity following short-term local Achilles tendon vibration may indicate improved cortical function during a submaximal dynamic exercise in female young soccer players. KW - Postactivation potentiation KW - electromyography KW - electroencephalography KW - maximum voluntary contraction KW - soccer Y1 - 2019 SN - 1303-2968 VL - 18 IS - 2 SP - 327 EP - 336 PB - Department of Sports Medicine, Medical Faculty of Uludag University CY - Bursa ER - TY - GEN A1 - Chaabene, Helmi A1 - Behm, David George A1 - Negra, Yassine A1 - Granacher, Urs T1 - Acute Effects of Static Stretching on Muscle Strength and Power BT - An Attempt to Clarify Previous Caveats T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - The effects of static stretching (StS) on subsequent strength and power activities has been one of the most debated topics in sport science literature over the past decades. The aim of this review is (1) to summarize previous and current findings on the acute effects of StS on muscle strength and power performances; (2) to update readers’ knowledge related to previous caveats; and (3) to discuss the underlying physiological mechanisms of short-duration StS when performed as single-mode treatment or when integrated into a full warm-up routine. Over the last two decades, StS has been considered harmful to subsequent strength and power performances. Accordingly, it has been recommended not to apply StS before strength- and power-related activities. More recent evidence suggests that when performed as a single-mode treatment or when integrated within a full warm-up routine including aerobic activity, dynamic-stretching, and sport-specific activities, short-duration StS (≤60 s per muscle group) trivially impairs subsequent strength and power activities (∆1–2%). Yet, longer StS durations (>60 s per muscle group) appear to induce substantial and practically relevant declines in strength and power performances (∆4.0–7.5%). Moreover, recent evidence suggests that when included in a full warm-up routine, short-duration StS may even contribute to lower the risk of sustaining musculotendinous injuries especially with high-intensity activities (e.g., sprint running and change of direction speed). It seems that during short-duration StS, neuromuscular activation and musculotendinous stiffness appear not to be affected compared with long-duration StS. Among other factors, this could be due to an elevated muscle temperature induced by a dynamic warm-up program. More specifically, elevated muscle temperature leads to increased muscle fiber conduction-velocity and improved binding of contractile proteins (actin, myosin). Therefore, our previous understanding of harmful StS effects on subsequent strength and power activities has to be updated. In fact, short-duration StS should be included as an important warm-up component before the uptake of recreational sports activities due to its potential positive effect on flexibility and musculotendinous injury prevention. However, in high-performance athletes, short-duration StS has to be applied with caution due to its negligible but still prevalent negative effects on subsequent strength and power performances, which could have an impact on performance during competition. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 585 KW - passive stretching KW - physical fitness KW - physiology KW - range of motion KW - injury Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440036 SN - 1866-8364 IS - 585 ER - TY - JOUR A1 - Chaabene, Helmi A1 - Behm, David George A1 - Negra, Yassine A1 - Granacher, Urs T1 - Acute Effects of Static Stretching on Muscle Strength and Power BT - An Attempt to Clarify Previous Caveats JF - Frontiers in Physiology N2 - The effects of static stretching (StS) on subsequent strength and power activities has been one of the most debated topics in sport science literature over the past decades. The aim of this review is (1) to summarize previous and current findings on the acute effects of StS on muscle strength and power performances; (2) to update readers’ knowledge related to previous caveats; and (3) to discuss the underlying physiological mechanisms of short-duration StS when performed as single-mode treatment or when integrated into a full warm-up routine. Over the last two decades, StS has been considered harmful to subsequent strength and power performances. Accordingly, it has been recommended not to apply StS before strength- and power-related activities. More recent evidence suggests that when performed as a single-mode treatment or when integrated within a full warm-up routine including aerobic activity, dynamic-stretching, and sport-specific activities, short-duration StS (≤60 s per muscle group) trivially impairs subsequent strength and power activities (∆1–2%). Yet, longer StS durations (>60 s per muscle group) appear to induce substantial and practically relevant declines in strength and power performances (∆4.0–7.5%). Moreover, recent evidence suggests that when included in a full warm-up routine, short-duration StS may even contribute to lower the risk of sustaining musculotendinous injuries especially with high-intensity activities (e.g., sprint running and change of direction speed). It seems that during short-duration StS, neuromuscular activation and musculotendinous stiffness appear not to be affected compared with long-duration StS. Among other factors, this could be due to an elevated muscle temperature induced by a dynamic warm-up program. More specifically, elevated muscle temperature leads to increased muscle fiber conduction-velocity and improved binding of contractile proteins (actin, myosin). Therefore, our previous understanding of harmful StS effects on subsequent strength and power activities has to be updated. In fact, short-duration StS should be included as an important warm-up component before the uptake of recreational sports activities due to its potential positive effect on flexibility and musculotendinous injury prevention. However, in high-performance athletes, short-duration StS has to be applied with caution due to its negligible but still prevalent negative effects on subsequent strength and power performances, which could have an impact on performance during competition. KW - passive stretching KW - physical fitness KW - physiology KW - range of motion KW - injury Y1 - 2019 U6 - https://doi.org/10.3389/fphys.2019.01468 SN - 1664-042X VL - 10 PB - Frontiers Research Foundation CY - Lausanne ER - TY - THES A1 - Paraskevopoulou, Sofia T1 - Adaptive genetic variation and responses to thermal stress in brachionid rotifers N2 - The importance of cryptic diversity in rotifers is well understood regarding its ecological consequences, but there remains an in depth comprehension of the underlying molecular mechanisms and forces driving speciation. Temperature has been found several times to affect species spatio-temporal distribution and organisms’ performance, but we lack information on the mechanisms that provide thermal tolerance to rotifers. High cryptic diversity was found recently in the freshwater rotifer “Brachionus calyciflorus”, showing that the complex comprises at least four species: B. calyciflorus sensu stricto (s.s.), B. fernandoi, B. dorcas, and B. elevatus. The temporal succession among species which have been observed in sympatry led to the idea that temperature might play a crucial role in species differentiation. The central aim of this study was to unravel differences in thermal tolerance between species of the former B. calyciflorus species complex by comparing phenotypic and gene expression responses. More specifically, I used the critical maximum temperature as a proxy for inter-species differences in heat-tolerance; this was modeled as a bi-dimensional phenotypic trait taking into consideration the intention and the duration of heat stress. Significant differences on heat-tolerance between species were detected, with B. calyciflorus s.s. being able to tolerate higher temperatures than B. fernandoi. Based on evidence of within species neutral genetic variation, I further examined adaptive genetic variability within two different mtDNA lineages of the heat tolerant B. calyciflorus s.s. to identify SNPs and genes under selection that might reflect their adaptive history. These analyses did not reveal adaptive genetic variation related to heat, however, they show putatively adaptive genetic variation which may reflect local adaptation. Functional enrichment of putatively positively selected genes revealed signals of adaptation in genes related to “lipid metabolism”, “xenobiotics biodegradation and metabolism” and “sensory system”, comprising candidate genes which can be utilized in studies on local adaptation. An absence of genetically-based differences in thermal adaptation between the two mtDNA lineages, together with our knowledge that B. calyciflorus s.s. can withstand a broad range of temperatures, led to the idea to further investigate shared transcriptomic responses to long-term exposure to high and low temperatures regimes. With this, I identified candidate genes that are involved in the response to temperature imposed stress. Lastly, I used comparative transcriptomics to examine responses to imposed heat-stress in heat-tolerant and heat-sensitive Brachionus species. I found considerably different patterns of gene expression in the two species. Most striking are patterns of expression regarding the heat shock proteins (hsps) between the two species. In the heat-tolerant, B. calyciflorus s.s., significant up-regulation of hsps at low temperatures was indicative of a stress response at the cooler end of the temperature regimes tested here. In contrast, in the heat-sensitive B. fernandoi, hsps generally exhibited up-regulation of these genes along with rising temperatures. Overall, identification of differences in expression of genes suggests suppression of protein biosynthesis to be a mechanism to increase thermal tolerance. Observed patterns in population growth are correlated with the hsp gene expression differences, indicating that this physiological stress response is indeed related to phenotypic life history performance. N2 - Obwohl die kryptische Diversität von Rotatorien (Rädertierchen) und die daraus resultierenden ökologischen Konsequenzen inzwischen sehr gut verstanden sind, sind die zugrunde liegenden molekularen Mechanismen und die Artbildungsprozesse bisher weitgehend unbekannt. Bekannt ist, dass die Temperatur eine bedeutende Rolle in den raum-zeitlichen Verbreitungsmustern der Arten sowie der Leistungsfähigkeit der Organismen, spielt. Es fehlen jedoch konkrete Informationen über die der Thermotoleranz zugrundeliegenden Mechanismen bei Rotatorien. Vor kurzem wurde hohe kryptische Diversität in der unter anderem in Süßwasser vorkommenden Art „Brachionus calyciflorus“ gefunden, so dass diese nun in mindestens vier Arten (B. calyciflorus sensu stricto (s.s.), B. fernandoi, B. dorcas und B. elevatus) unterteilt wurde. Beobachtungen von in Sympatrie vorkommenden Arten haben gezeigt, dass eine zeitliche Suksession innerhalb dieser Arten existiert, was vermuten lässt, dass Temperatur eine entscheidende Rolle bei der Artbildung gespielt haben könnte. Ziel dieser Arbeit ist es, Thermotoleranzunterschiede zwischen Arten des früheren B. calyciflorus-Artenkomplexes durch den Vergleich von phänotypischen und molekularen (Genexpression) Reaktionen auf Temperatur festzustellen. Die in dieser Untersuchung ermittelte kritische Maximaltemperatur wurde als Schätzer für zwischenartliche Hitzetoleranz verwendet. Mit Hilfe eines zweidimensionalen Verfahrens, welches sowohl die Dauer als auch die Stärke des Hitzestresses detektiert, konnte festgestellt werden, dass B. calyciflorus s.s. im Vergleich zu B. fernandoi hitzetoleranter ist. Auf Basis der innerartlichen genetischen Variation erfolgte eine tiefergehende Untersuchung zweier unterschiedlicher maternaler (mtDNA) Evolutionslinien der hitzetoleranteren Art B. calyciflorus s.s mit dem Ziel, unter divergenter Selektion stehende SNPs und Gene zu identifizieren, welche die Anpassung an verschiedene Temperaturen widerspiegeln könnten. Mit Hilfe dieses Experimentes war es möglich, potentiell positiv selektiere Kandidatengene zu identifizieren, welche im Zusammenhang mit dem „Lipidmetabolismus“, dem „Metabolismus und Abbau von Xenobiotika“ sowie dem „Sensorischen System“ stehen. Diese Kandidatengene lassen Rückschlüsse auf lokale Anpassungen zu. Es konnten keine genetischen Unterschiede gefunden werden, die im Zusammenhang mit der Temperaturanpassung der beiden untersuchten Evolutionslinien stehen. Um molekulare Grundlagen für die Toleranz von B. calyciflorus s.s für einen großen Temperaturbereich zu identifizieren, wurde das Transkriptom untersucht. Mit Hilfe der erhobenen Daten konnten Kandidatengene identifiziert werden, die für die Temperaturtoleranz von Bedeutung sind. Der letzte Teil dieser Arbeit konzentrierte sich auf die Untersuchung der Hitzestressantwort in einer hitzetoleranten und einer hitzesensitiven Brachionus Art. Diese Untersuchung konnte erhebliche Unterschiede in den Genexpre-ssionsmustern der beiden Arten aufzeigen. Die deutlichsten Unterschiede der Genexpression wurden hierbei in der Expression von Genen detektiert, die für die sogenannten Hitze-Schock-Proteinen (Heat-shock-proteins: hsp) codieren. In der hitzetoleranten Art B. calyciflorus s.s wurde ein signifikanter Anstieg der hsp-Genexpression bei geringen Temperaturen festgestellt, während bei der hitzesensitiven Art B. fernandoi ein signifikanter Anstieg bei hohen Temperaturen detektiert wurde. Die in dieser Arbeit gefundenen Unterschiede in der Genexpression zeigen, dass Temperaturstress eine Hemmung der Proteinbiosynthese bewirken kann, was zu einer erhöhten Thermotoleranz führt. Darüber hinaus ist Populationswachstum mit der Expression von Hitze-Schock-Proteingenen korreliert. Dies deutet darauf hin, dass die hier beschriebene physiologische Temperaturstressantwort tatsächlich mit den beobachteten phänotypischen Fitnessparametern im Zusammenhang steht. KW - Brachionus KW - zooplankton KW - temperature KW - RNA-seq KW - transcriptome KW - adaptation Y1 - 2019 ER - TY - JOUR A1 - Radchuk, Viktoriia A1 - Reed, Thomas A1 - Teplitsky, Celine A1 - van de Pol, Martijn A1 - Charmantier, Anne A1 - Hassall, Christopher A1 - Adamik, Peter A1 - Adriaensen, Frank A1 - Ahola, Markus P. A1 - Arcese, Peter A1 - Miguel Aviles, Jesus A1 - Balbontin, Javier A1 - Berg, Karl S. A1 - Borras, Antoni A1 - Burthe, Sarah A1 - Clobert, Jean A1 - Dehnhard, Nina A1 - de Lope, Florentino A1 - Dhondt, Andre A. A1 - Dingemanse, Niels J. A1 - Doi, Hideyuki A1 - Eeva, Tapio A1 - Fickel, Jörns A1 - Filella, Iolanda A1 - Fossoy, Frode A1 - Goodenough, Anne E. A1 - Hall, Stephen J. G. A1 - Hansson, Bengt A1 - Harris, Michael A1 - Hasselquist, Dennis A1 - Hickler, Thomas A1 - Jasmin Radha, Jasmin A1 - Kharouba, Heather A1 - Gabriel Martinez, Juan A1 - Mihoub, Jean-Baptiste A1 - Mills, James A. A1 - Molina-Morales, Mercedes A1 - Moksnes, Arne A1 - Ozgul, Arpat A1 - Parejo, Deseada A1 - Pilard, Philippe A1 - Poisbleau, Maud A1 - Rousset, Francois A1 - Rödel, Mark-Oliver A1 - Scott, David A1 - Carlos Senar, Juan A1 - Stefanescu, Constanti A1 - Stokke, Bard G. A1 - Kusano, Tamotsu A1 - Tarka, Maja A1 - Tarwater, Corey E. A1 - Thonicke, Kirsten A1 - Thorley, Jack A1 - Wilting, Andreas A1 - Tryjanowski, Piotr A1 - Merila, Juha A1 - Sheldon, Ben C. A1 - Moller, Anders Pape A1 - Matthysen, Erik A1 - Janzen, Fredric A1 - Dobson, F. Stephen A1 - Visser, Marcel E. A1 - Beissinger, Steven R. A1 - Courtiol, Alexandre A1 - Kramer-Schadt, Stephanie T1 - Adaptive responses of animals to climate change are most likely insufficient JF - Nature Communications N2 - Biological responses to climate change have been widely documented across taxa and regions, but it remains unclear whether species are maintaining a good match between phenotype and environment, i.e. whether observed trait changes are adaptive. Here we reviewed 10,090 abstracts and extracted data from 71 studies reported in 58 relevant publications, to assess quantitatively whether phenotypic trait changes associated with climate change are adaptive in animals. A meta-analysis focussing on birds, the taxon best represented in our dataset, suggests that global warming has not systematically affected morphological traits, but has advanced phenological traits. We demonstrate that these advances are adaptive for some species, but imperfect as evidenced by the observed consistent selection for earlier timing. Application of a theoretical model indicates that the evolutionary load imposed by incomplete adaptive responses to ongoing climate change may already be threatening the persistence of species. Y1 - 2019 U6 - https://doi.org/10.1038/s41467-019-10924-4 SN - 2041-1723 VL - 10 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Andress, Reinhard T1 - Addendum: a second Poem by Eduard Dorsch on the occasion of Humboldt’s 100th birthday JF - HiN : Alexander von Humboldt im Netz ; international review for Humboldtian studies N2 - In a previously published article in HIN under the title of “Eduard Dorsch and his unpublished poem on the occasion of Humboldt’s 100th birthday,” I elaborated on Dorsch’s poem that was read in Detroit in front of a German-American audience on Sept. 14, 1869, a day widely celebrated in the US in honor of Humboldt. Although it was not surprising that Dorsch wrote the occasional poem in the first place given his affinities with Humboldt’s world of thought, a discovery of a second occasional poem upon further research in Dorsch’s voluminous papers was indeed unexpected, in this case read on the same date in Monroe, Michigan. Although there are a number of similarities between the Detroit and Monroe versions, there are enough differences that warrant this addendum to my original article. N2 - In einem bereits in HIN veröffentlichten Artikel mit dem Titel Eduard Dorsch und sein unveröffentlichtes Gelegenheitsgedicht zu Humboldts 100. Geburtstag ging ich auf Dorschs Gedicht ein, das am 14. September 1869 vor einem deutsch-amerikanischen Publikum in Detroit verlesen wurde, an einem Tag, der überall zu Ehren Humboldts in den USA gefeiert wurde. Obwohl es nicht überraschend ist, dass Dorsch angesichts seiner Affinität zu Humboldts Gedankenwelt das Gedicht überhaupt schrieb, war der Fund eines zweiten Gelegenheitsgedichts in Dorschs umfangreichem Nachlass dennoch unerwartet, in diesem Falle am selben Tag in Monroe, Michigan verlesen. Obwohl es eine Reihe von Ähnlichkeiten zwischen den Detroit- und Monroe-Versionen gibt, tauchen auch genug Unterschiede auf, um diesen Nachtrag zu meinem ursprünglichen Artikel zu rechtfertigen. N2 - En un artículo ya publicado en HIN bajo el título de "Eduard Dorsch y su poema inédito con motivo del centenario de Humboldt", abordé el poema de Dorsch leído en Detroit frente a una audiencia germano-estadounidense el 14 de septiembre de 1869, un día ampliamente celebrado en los Estados Unidos en honor a Humboldt. Aunque no sorprende que Dorsch escribiera el poema de ocasión debido a sus afinidades con la cosmovisión de Humboldt, lo inesperado fue el hallazgo de un segundo poema para la misma ocasión durante un estudio adicional de los voluminosos papeles de Dorsch. Este segundo poema fue leído en la misma fecha en Monroe, Michigan. Si bien existe una serie de similitudes entre las versiones creadas para Detroit y Monroe, también hay suficientes diferencias que justifican este apéndice a mi artículo original. Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442585 SN - 2568-3543 SN - 1617-5239 VL - XX IS - 39 SP - 61 EP - 70 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Neiber, Marco Thomas A1 - Kahl, Sandra M. A1 - Wiggering, Benedikt A1 - Glaubrecht, Matthias T1 - Adding the West-African riverine component BT - Revision of the Recent freshwater snails belonging to Pseudocleopatra Thiele, 1928 (Caenogastropoda, Cerithioidea, Paludomidae) JF - Zootaxa : an international journal of zootaxonomy ; a rapid international journal for animal taxonomists N2 - While Africa’s lacustrine gastropod fauna, in particular of Lake Tanganyika, has received much attention, the continent’s riverine malacofauna has long been neglected. Pseudocleopatra is a relatively poorly known paludomid gastropod genus with species found throughout the lower reaches of the West African Volta and Congo rivers. In the course of ongoing systematic revisions of African paludomids, we present here a morphometric analysis and revision of the recent species assigned to the genus, i.e., P. togoensis, P. voltana, P. dartevellei and P. bennikei, to improve taxonomic acuity for this group. We use available museum material for geometric morphometrics, multivariate ratio analysis and comparisons of radular and opercular characters. Our results demonstrate that the four recent species of Pseudocleopatra are clearly distinguishable on the basis of ratios of shell measurements as well as radular and opercular characters. Pseudocleopatra has generic-level synapomorphies including: concentric opercula with relatively large paucispiral nuclei, and rachidian radular teeth with usually 13–20 cusps. On the basis of this characterisation, the nominal species Cleopatra broecki is transferred to Pseudocleopatra. Additionally, the nominal taxon P. bennikei is synonymized with P. broecki n. comb. The phylogenetic relationships of Pseudocleopatra are currently unknown, but the observed tendency of some fossil taxa assigned to Pseudocleopatra towards thalassoidism, i.e., the resemblance to marine gastropods, has led to the hypothesis that some of the thalassoid endemics in Lake Tanganyika may have originated from or be related to Pseudocleopatra. Should this hypothesis be correct, which is in need of testing by molecular genetic methods when suitable samples become available, Pseudocleopatra may play a crucial role in understanding of the evolution of thalassoidism in African Paludomidae. KW - Africa KW - Congo River KW - Volta River KW - thalassoidism KW - geometric morphometrics KW - multivariate ratio analysis Y1 - 2019 U6 - https://doi.org/10.11646/zootaxa.4674.3.1 SN - 1175-5326 SN - 1175-5334 VL - 4674 IS - 3 SP - 301 EP - 328 PB - Magnolia Press CY - Auckland ER - TY - GEN A1 - Hesse, Günter A1 - Matthies, Christoph A1 - Sinzig, Werner A1 - Uflacker, Matthias T1 - Adding Value by Combining Business and Sensor Data BT - an Industry 4.0 Use Case T2 - Database Systems for Advanced Applications N2 - Industry 4.0 and the Internet of Things are recent developments that have lead to the creation of new kinds of manufacturing data. Linking this new kind of sensor data to traditional business information is crucial for enterprises to take advantage of the data’s full potential. In this paper, we present a demo which allows experiencing this data integration, both vertically between technical and business contexts and horizontally along the value chain. The tool simulates a manufacturing company, continuously producing both business and sensor data, and supports issuing ad-hoc queries that answer specific questions related to the business. In order to adapt to different environments, users can configure sensor characteristics to their needs. KW - Industry 4.0 KW - Internet of Things KW - Data integration Y1 - 2019 SN - 978-3-030-18590-9 SN - 978-3-030-18589-3 U6 - https://doi.org/10.1007/978-3-030-18590-9_80 SN - 0302-9743 SN - 1611-3349 VL - 11448 SP - 528 EP - 532 PB - Springer CY - Cham ER - TY - JOUR A1 - Steinmeier, Frank-Walter T1 - Address on the opening of the Alexander von Humboldt Season in Quito, Ecuador, on 13 February 2019 JF - HiN : Alexander von Humboldt im Netz ; international review for Humboldtian studies KW - Alexander von Humboldt Season KW - Federal President KW - trip to South America KW - Quito KW - Ecuador KW - Aimé Bonpland KW - second discoverer of America KW - Humboldt y las Américas Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-434723 SN - 2568-3543 SN - 1617-5239 VL - XX IS - 39 SP - 23 EP - 30 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Wright, Michelle F. A1 - Wachs, Sebastian T1 - Adolescents’ Psychological Consequences and Cyber Victimization BT - The Moderation of School-Belongingness and Ethnicity JF - International Journal of Environmental Research and Public Health N2 - Cyber victimization research reveals various personal and contextual correlations and negative consequences associated with this experience. Despite increasing attention on cyber victimization, few studies have examined such experiences among ethnic minority adolescents. The purpose of the present study was to examine the moderating effect of ethnicity in the longitudinal associations among cyber victimization, school-belongingness, and psychological consequences (i.e., depression, loneliness, anxiety). These associations were investigated among 416 Latinx and white adolescents (46% female; M age = 13.89, SD = 0.41) from one middle school in the United States. They answered questionnaires on cyber victimization, school belongingness, depression, loneliness, and anxiety in the 7th grade (Time 1). One year later, in the 8th grade (Time 2), they completed questionnaires on depression, loneliness, and anxiety. Low levels of school-belongingness strengthened the positive relationships between cyber victimization and Time 2 depression and anxiety, especially among Latinx adolescents. The positive association between cyber victimization and Time 2 loneliness was strengthened for low levels of school-belongingness for all adolescents. These findings may indicate that cyber victimization threatens adolescents’ school-belongingness, which has implications for their emotional adjustment. Such findings underscore the importance of considering diverse populations when examining cyber victimization. KW - cyberbullying KW - cyber victimization KW - depression KW - anxiety KW - loneliness KW - Latinx KW - Latino KW - adolescents KW - ethnic KW - ethnic differences Y1 - 2019 U6 - https://doi.org/10.3390/ijerph16142493 SN - 1661-7827 SN - 1660-4601 VL - 16 PB - MDPI AG CY - Basel ER - TY - GEN A1 - Wright, Michelle F. A1 - Wachs, Sebastian T1 - Adolescents’ Psychological Consequences and Cyber Victimization BT - The Moderation of School-Belongingness and Ethnicity T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Cyber victimization research reveals various personal and contextual correlations and negative consequences associated with this experience. Despite increasing attention on cyber victimization, few studies have examined such experiences among ethnic minority adolescents. The purpose of the present study was to examine the moderating effect of ethnicity in the longitudinal associations among cyber victimization, school-belongingness, and psychological consequences (i.e., depression, loneliness, anxiety). These associations were investigated among 416 Latinx and white adolescents (46% female; M age = 13.89, SD = 0.41) from one middle school in the United States. They answered questionnaires on cyber victimization, school belongingness, depression, loneliness, and anxiety in the 7th grade (Time 1). One year later, in the 8th grade (Time 2), they completed questionnaires on depression, loneliness, and anxiety. Low levels of school-belongingness strengthened the positive relationships between cyber victimization and Time 2 depression and anxiety, especially among Latinx adolescents. The positive association between cyber victimization and Time 2 loneliness was strengthened for low levels of school-belongingness for all adolescents. These findings may indicate that cyber victimization threatens adolescents’ school-belongingness, which has implications for their emotional adjustment. Such findings underscore the importance of considering diverse populations when examining cyber victimization. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 578 KW - cyberbullying KW - cyber victimization KW - depression KW - anxiety KW - loneliness KW - Latinx KW - Latino KW - adolescents KW - ethnic KW - ethnic differences Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437868 SN - 1866-8364 IS - 578 ER - TY - JOUR A1 - Bonache, Helena A1 - Gonzalez-Mendez, Rosaura A1 - Krahe, Barbara T1 - Adult attachment styles, destructive conflict resolution, and the experience of intimate partner violence JF - Journal of interpersonal violence : concerned with the study and treatment of victims and perpetrators of physical and sexual violence N2 - Although there is ample evidence linking insecure attachment styles and intimate partner violence (IPV), little is known about the psychological processes underlying this association, especially from the victim’s perspective. The present study examined how attachment styles relate to the experience of sexual and psychological abuse, directly or indirectly through destructive conflict resolution strategies, both self-reported and attributed to their opposite-sex romantic partner. In an online survey, 216 Spanish undergraduates completed measures of adult attachment style, engagement and withdrawal conflict resolution styles shown by self and partner, and victimization by an intimate partner in the form of sexual coercion and psychological abuse. As predicted, anxious and avoidant attachment styles were directly related to both forms of victimization. Also, an indirect path from anxious attachment to IPV victimization was detected via destructive conflict resolution strategies. Specifically, anxiously attached participants reported a higher use of conflict engagement by themselves and by their partners. In addition, engagement reported by the self and perceived in the partner was linked to an increased probability of experiencing sexual coercion and psychological abuse. Avoidant attachment was linked to higher withdrawal in conflict situations, but the paths from withdrawal to perceived partner engagement, sexual coercion, and psychological abuse were non-significant. No gender differences in the associations were found. The discussion highlights the role of anxious attachment in understanding escalating patterns of destructive conflict resolution strategies, which may increase the vulnerability to IPV victimization. KW - attachment styles KW - conflict resolution KW - intimate partner violence KW - psychological abuse KW - sexual coercion Y1 - 2016 U6 - https://doi.org/10.1177/0886260516640776 SN - 0886-2605 SN - 1552-6518 VL - 34 IS - 2 SP - 287 EP - 309 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Taubert, Andreas A1 - Leroux, Fabrice A1 - Rabu, Pierre A1 - de Zea Bermudez, Veronica T1 - Advanced hybrid nanomaterials JF - Beilstein journal of nanotechnology KW - colloidal chemistry KW - environmental remediation KW - hybrid nanomaterials KW - nanocomposite KW - nanofillers KW - nanomedicine KW - nanostructures KW - polymer fillers KW - pore templating KW - smart materials Y1 - 2019 U6 - https://doi.org/10.3762/bjnano.10.247 SN - 2190-4286 VL - 10 SP - 2563 EP - 2567 PB - Beilstein-Institut zur Förderung der Chemischen Wissenschaften CY - Frankfurt am Main ER - TY - GEN A1 - Brieger, Frederic A1 - Herzschuh, Ulrike A1 - Pestryakova, Luidmila Agafyevna A1 - Bookhagen, Bodo A1 - Zakharov, Evgenii S. A1 - Kruse, Stefan T1 - Advances in the derivation of Northeast Siberian forest metrics using high-resolution UAV-based photogrammetric point clouds T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Forest structure is a crucial component in the assessment of whether a forest is likely to act as a carbon sink under changing climate. Detailed 3D structural information about the tundra–taiga ecotone of Siberia is mostly missing and still underrepresented in current research due to the remoteness and restricted accessibility. Field based, high-resolution remote sensing can provide important knowledge for the understanding of vegetation properties and dynamics. In this study, we test the applicability of consumer-grade Unmanned Aerial Vehicles (UAVs) for rapid calculation of stand metrics in treeline forests. We reconstructed high-resolution photogrammetric point clouds and derived canopy height models for 10 study sites from NE Chukotka and SW Yakutia. Subsequently, we detected individual tree tops using a variable-window size local maximum filter and applied a marker-controlled watershed segmentation for the delineation of tree crowns. With this, we successfully detected 67.1% of the validation individuals. Simple linear regressions of observed and detected metrics show a better correlation (R2) and lower relative root mean square percentage error (RMSE%) for tree heights (mean R2 = 0.77, mean RMSE% = 18.46%) than for crown diameters (mean R2 = 0.46, mean RMSE% = 24.9%). The comparison between detected and observed tree height distributions revealed that our tree detection method was unable to representatively identify trees <2 m. Our results show that plot sizes for vegetation surveys in the tundra–taiga ecotone should be adapted to the forest structure and have a radius of >15–20 m to capture homogeneous and representative forest stands. Additionally, we identify sources of omission and commission errors and give recommendations for their mitigation. In summary, the efficiency of the used method depends on the complexity of the forest’s stand structure. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1337 KW - UAV KW - photogrammetry KW - remote sensing KW - structure from motion KW - tundra–taiga ecotone KW - point cloud KW - forest structure Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473318 SN - 1866-8372 IS - 1337 ER - TY - JOUR A1 - Brieger, Frederic A1 - Herzschuh, Ulrike A1 - Pestryakova, Luidmila Agafyevna A1 - Bookhagen, Bodo A1 - Zakharov, Evgenii S. A1 - Kruse, Stefan T1 - Advances in the Derivation of Northeast Siberian Forest Metrics Using High-Resolution UAV-Based Photogrammetric Point Clouds JF - Remote sensing N2 - Forest structure is a crucial component in the assessment of whether a forest is likely to act as a carbon sink under changing climate. Detailed 3D structural information about the tundra–taiga ecotone of Siberia is mostly missing and still underrepresented in current research due to the remoteness and restricted accessibility. Field based, high-resolution remote sensing can provide important knowledge for the understanding of vegetation properties and dynamics. In this study, we test the applicability of consumer-grade Unmanned Aerial Vehicles (UAVs) for rapid calculation of stand metrics in treeline forests. We reconstructed high-resolution photogrammetric point clouds and derived canopy height models for 10 study sites from NE Chukotka and SW Yakutia. Subsequently, we detected individual tree tops using a variable-window size local maximum filter and applied a marker-controlled watershed segmentation for the delineation of tree crowns. With this, we successfully detected 67.1% of the validation individuals. Simple linear regressions of observed and detected metrics show a better correlation (R2) and lower relative root mean square percentage error (RMSE%) for tree heights (mean R2 = 0.77, mean RMSE% = 18.46%) than for crown diameters (mean R2 = 0.46, mean RMSE% = 24.9%). The comparison between detected and observed tree height distributions revealed that our tree detection method was unable to representatively identify trees <2 m. Our results show that plot sizes for vegetation surveys in the tundra–taiga ecotone should be adapted to the forest structure and have a radius of >15–20 m to capture homogeneous and representative forest stands. Additionally, we identify sources of omission and commission errors and give recommendations for their mitigation. In summary, the efficiency of the used method depends on the complexity of the forest’s stand structure. KW - UAV KW - photogrammetry KW - remote sensing KW - structure from motion KW - tundra-taiga ecotone KW - point cloud KW - forest structure Y1 - 2019 U6 - https://doi.org/10.3390/rs11121447 SN - 2072-4292 VL - 11 IS - 12 PB - MDPI CY - Basel ER - TY - THES A1 - Kegelmann, Lukas T1 - Advancing charge selective contacts for efficient monolithic perovskite-silicon tandem solar cells T1 - Entwicklung Ladungsselektiver Kontakte für Effiziente Monolithische Perowskit-Silizium Tandem-Solarzellen N2 - Hybrid organic-inorganic perovskites are one of the most promising material classes for photovoltaic energy conversion. In solar cells, the perovskite absorber is sandwiched between n- and p-type contact layers which selectively transport electrons and holes to the cell’s cathode and anode, respectively. This thesis aims to advance contact layers in perovskite solar cells and unravel the impact of interface and contact properties on the device performance. Further, the contact materials are applied in monolithic perovskite-silicon heterojunction (SHJ) tandem solar cells, which can overcome the single junction efficiency limits and attract increasing attention. Therefore, all contact layers must be highly transparent to foster light harvesting in the tandem solar cell design. Besides, the SHJ device restricts processing temperatures for the selective contacts to below 200°C. A comparative study of various electron selective contact materials, all processed below 180°C, in n-i-p type perovskite solar cells highlights that selective contacts and their interfaces to the absorber govern the overall device performance. Combining fullerenes and metal-oxides in a TiO2/PC60BM (phenyl-C60-butyric acid methyl ester) double-layer contact allows to merge good charge extraction with minimized interface recombination. The layer sequence thereby achieved high stabilized solar cell performances up to 18.0% and negligible current-voltage hysteresis, an otherwise pronounced phenomenon in this device design. Double-layer structures are therefore emphasized as a general concept to establish efficient and highly selective contacts. Based on this success, the concept to combine desired properties of different materials is transferred to the p-type contact. Here, a mixture of the small molecule Spiro-OMeTAD [2,2’,7,7’-tetrakis(N,N-di-p-methoxyphenylamine)-9,9’-spirobifluoren] and the doped polymer PEDOT [poly(3,4-ethylenedioxythiophene)] is presented as a novel hole selective contact. PEDOT thereby remarkably suppresses charge recombination at the perovskite surface, allowing an increase of quasi-Fermi level splitting in the absorber. Further, the addition of Spiro-OMeTAD into the PEDOT layer is shown to enhance charge extraction at the interface and allow high efficiencies up to 16.8%. Finally, the knowledge on contact properties is applied to monolithic perovskite-SHJ tandem solar cells. The main goal is to optimize the top contact stack of doped Spiro-OMeTAD/molybdenum oxide(MoOx)/ITO towards higher transparency by two different routes. First, fine-tuning of the ITO deposition to mitigate chemical reduction of MoOx and increase the transmittance of MoOx/ITO stacks by 25%. Second, replacing Spiro-OMeTAD with the alternative hole transport materials PEDOT/Spiro-OMeTAD mixtures, CuSCN or PTAA [poly(triaryl amine)]. Experimental results determine layer thickness constrains and validate optical simulations, which subsequently allow to realistically estimate the respective tandem device performances. As a result, PTAA represents the most promising replacement for Spiro-OMeTAD, with a projected increase of the optimum tandem device efficiency for the herein used architecture by 2.9% relative to 26.5% absolute. The results also reveal general guidelines for further performance gains of the technology. N2 - Hybride, organisch-anorganische Perowskite gelten als eine der vielversprechendsten Materialklassen für die photovoltaische Energieumwandlung. Dazu werden Perowskit-Absorber in Solarzellen zwischen n- und p-Typ Kontaktschichten angeordnet, die Elektronen oder Löcher selektiv zur Kathode bzw. Anode der Zelle transportieren. Ziel dieser Arbeit ist es, die ladungsselektiven Transportschichten in Perowskit-Solarzellen zu verbessern und Einflüsse der Grenzflächen- und Kontakteigenschaften auf die Zelleffizienz herauszustellen. Darüber hinaus werden die selektiven Schichten in monolithischen Perowskit-Silizium-Heterokontakt (SHK) Tandem-Solarzellen eingesetzt. Diese können höhere Wirkungsgrade als Einfachsolarzellen erzielen und erfahren zunehmende Aufmerksamkeit aus der Forschung. Hierfür müssen alle Kontaktschichten hochtransparent sein, um eine möglichst effiziente Lichtausnutzung im Tandem-Solarzellen-Design zu erzielen. Des Weiteren limitiert die SHK-Solarzelle die höchst mögliche Temperatur zur Abscheidung der selektiven Kontakte auf 200°C. In einer Vergleichsstudie werden deshalb zunächst verschiedene elektronenselektive Kontaktmaterialien, die alle unter 180°C prozessiert werden, in n-i-p-Typ Perowskit-Solarzellen eingesetzt. Es zeigt sich hierbei, wie wesentlich die selektiven Kontakte und ihre Grenzflächen zum Absorber die Effizienz der Solarzellen bestimmen. Eine Kombination aus Fulleren und Metalloxid in einem TiO2/PC60BM (Phenyl-C60-Buttersäuremethylester) Doppelschichtkontakt ermöglicht dabei eine besonders gute Ladungsextraktion und stark reduzierte Grenzflächenrekombination. Die Materialzusammenstellung erreicht in der Studie hohe stabilisierte Solarzellenwirkungsgrade bis zu 18,0% und eine vernachlässigbare Strom-Spannungs-Hysterese, ein üblicherweise ausgeprägtes Phänomen in diesem Zellaufbau. Das Ergebnis stellt Doppelschicht-Strukturen als generelles Konzept zur Herstellung effizienter und hochselektiver Kontakte heraus. Basierend auf diesem Erfolg wird das Konzept, Eigenschaften verschiedener Materialien miteinander zu kombinieren, anschließend auf den p-Typ Kontakt übertragen. Dazu wird ein neuartiger lochselektiver Kontakt vorgestellt, bestehend aus einer Mischung des kleinen Moleküls Spiro-OMeTAD [2,2‘7,7‘-tetrakis(N,N-di-p-methoxyphenylamin)-9,9‘-spirobifluoren] und dem dotierten Polymer PEDOT [poly(3,4-ethylendioxythiophen)]. PEDOT unterdrückt dabei bemerkenswerter Weiße die Ladungsträgerrekombination an der Perowskit-Grenzfläche, wodurch eine Erhöhung der Quasi-Fermi-Niveau-Aufspaltung im Absorber erzielt wird. Weiterhin wird gezeigt, dass die Zugabe von Spiro-OMeTAD in die PEDOT-Schicht die Lochextraktion an der Grenzfläche verbessert und folglich hohe Solarzellenwirkungsgrade von bis zu 16,8% ermöglicht. Schließlich wird das gewonnene Wissen über die Bedeutung der Kontakt- und Grenzflächeneigenschaften auf monolithische Perowskit-SHK-Tandemsolarzellen angewandt. Das Hauptziel dabei ist die Optimierung des oberen Kontaktstapels, bestehend aus dotiertem Spiro-OMeTAD/Molybdän Oxid (MoOx)/ITO, hin zu verbesserter Transparenz. Zwei verschiedene Ansätze werden hierzu verfolgt. Erstens, durch Feinanpassung der ITO-Abscheidung kann eine chemische Reduktion von MoOx verringert und die Transmission von MoOx/ITO-Schichtstapeln um 25% erhöht werden. Zweitens: Durch Ersetzen des Spiro-OMeTAD mit alternativen, transparenteren Lochtransportmaterialien sollen parasitäre Absorptionsverluste vermieden werden. Als potentielle Lochkontakte werden dabei PEDOT/Spiro-OMeTAD-Mischungen, CuSCN und PTAA [Poly(triarylamin)] analysiert. Experimentelle Untersuchungen liefern optimierte Dicken der Lochkontakt und MoOx Schichten und dienen der Validierung optischer Simulationen der Schichtstapel. Dies erlaubt im Folgenden eine realistische Abschätzung der maximal erreichbaren Tandemsolarzelleneffizienzen. Dabei stellt PTAA den vielversprechendsten Ersatz für Spiro-OMeTAD dar, mit einer prognostizierten Erhöhung des erreichbaren Tandem-Solarzellenwirkungsgrad um 2,9% relativ auf 26,5% absolut. Die Ergebnisse stellen zudem einen Leitfaden zur weiteren Effizienzsteigerung der Tandemsolarzellen-Technologie dar. KW - perovskite KW - silicon KW - tandem solar cell KW - interface engineering KW - contact layers KW - Perowskit KW - Silizium KW - Tandem-Solarzelle KW - Interface-Engineering KW - Kontaktschichten Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-426428 ER - TY - JOUR A1 - Ekkekakis, Panteleimon A1 - Brand, Ralf T1 - Affective responses to and automatic affective valuations of physical activity BT - Fifty years of progress on the seminal question in exercise psychology JF - Psychology of sport and exercise N2 - Objective: To critically review developments over the first fifty years of research (1967-2017) on (a) how people feel when they participate in exercise and physical activity, and (b) the implications of these responses for their willingness to become and remain active. Design: Non-systematic narrative review. Method: Representative sources were selected through a combination of computer searches and cross-referencing. Results: For over three decades, exercise psychology exhibited a fixation on the idea that exercise and physical activity make people feel better. This notion, however, seemed to contrast with evidence that most adults in industrialized countries exhibit low levels of activity. In the last two decades, a critical examination and overhaul of the methodological platform resulted in the delineation of a dose-response pattern that encompasses positive as well as negative affective responses, and revealed marked interindividual differences. An emerging literature is aimed at refining and testing integrative dual-process models that can offer specific predictions about the behaviors that may result from the interaction of automatic processes (theorized to be heavily influenced by past affective experiences) and deliberative processes (such as cognitive appraisals). Conclusions: Affective responses to exercise and physical activity are more complex than the long-popularized "feel-better" effect, encompassing both pleasant and unpleasant experiences and exhibiting marked inter individual variation. The potential of affective experiences to influence subsequent behavior offers an opportunity for an expanded theoretical perspective in exercise psychology. KW - Pleasure KW - Displeasure KW - Ventilatory threshold KW - Automatic affective valuation Y1 - 2019 U6 - https://doi.org/10.1016/j.psychsport.2018.12.018 SN - 1469-0292 SN - 1878-5476 VL - 42 SP - 130 EP - 137 PB - Elsevier CY - Amsterdam ER - TY - BOOK A1 - Zimmermann, Andreas A1 - Freiburg-Braun, Elisa T1 - Aggression under the Rome Statute BT - an introduction N2 - Das Werk analysiert umfassend das Verbrechen der Aggression im Sinne des Römischen Statuts. Ausgehend von der Rechtsgeschichte, werde die einschlägigen Artikel 8bis, 15bis und 15ter des Römischen Statuts, also die Definition des Verbrechens der Aggression, analysiert. Ebenso behandelt das Buch weiterführende Entwicklungen des Verbrechens der Aggression über das Jahr 2017 hinaus – das Jahr, in dem es, wahrscheinlich, zu einer Entscheidung über die Aktivierung der Gerichtsbarkeit kommt Y1 - 2019 SN - 978-3-8487-4678-1 PB - Nomos CY - Baden-Baden ER - TY - GEN A1 - Matthies, Christoph T1 - Agile process improvement in retrospectives T2 - 41st International Conference on Software Engineering: Companion Proceedings (ICSE-Companion) N2 - Working in iterations and repeatedly improving team workflows based on collected feedback is fundamental to agile software development processes. Scrum, the most popular agile method, provides dedicated retrospective meetings to reflect on the last development iteration and to decide on process improvement actions. However, agile methods do not prescribe how these improvement actions should be identified, managed or tracked in detail. The approaches to detect and remove problems in software development processes are therefore often based on intuition and prior experiences and perceptions of team members. Previous research in this area has focused on approaches to elicit a team's improvement opportunities as well as measurements regarding the work performed in an iteration, e.g. Scrum burn-down charts. Little research deals with the quality and nature of identified problems or how progress towards removing issues is measured. In this research, we investigate how agile development teams in the professional software industry organize their feedback and process improvement approaches. In particular, we focus on the structure and content of improvement and reflection meetings, i.e. retrospectives, and their outcomes. Researching how the vital mechanism of process improvement is implemented in practice in modern software development leads to a more complete picture of agile process improvement. KW - Agile KW - Scrum KW - software process improvement KW - retrospective Y1 - 2019 SN - 978-1-7281-1764-5 SN - 978-1-7281-1765-2 U6 - https://doi.org/10.1109/ICSE-Companion.2019.00063 SN - 2574-1934 SN - 2574-1926 SP - 150 EP - 152 PB - IEEE CY - New York ER - TY - JOUR A1 - Reike, Dennis A1 - Schwarz, Wolfgang T1 - Aging effects on symbolic number comparison BT - no deceleration of numerical information retrieval but more conservative decision-making JF - Psychology and aging N2 - Whereas many cognitive tasks show pronounced aging effects, even in healthy older adults, other tasks seem more resilient to aging. A small number of recent studies suggests that number comparison is possibly one of the abilities that remain unaltered across the life span. We investigated the ability to compare single-digit numbers in young (19-39 years; n = 39) and healthy older (65-79 years; n = 39) adults in considerable detail, analyzing accuracy as well as mean and variance of their response time, together with several other well-established hallmarks of numerical comparison. Using a recent comprehensive process model that parsimoniously accounts quantitatively for many aspects of number comparison (Reike & Schwarz, 2016), we address two fundamental problems in the comparison of older to young adults in numerical comparison tasks: (a) to adequately correct speed measures for different levels of accuracy (older participants were significantly more accurate than young participants), and (b) to distinguish between general sensory and motor slowing on the one hand, as opposed to a specific age-related decline in the efficiency to retrieve and compare numerical magnitude representations. Our results represent strong evidence that healthy older adults compare magnitudes as efficiently as young adults, when the measure of efficiency is uncontaminated by strategic speed-accuracy trade-offs and by sensory and motor stages that are not related to numerical comparison per se. At the same time, older adults aim at a significantly higher accuracy level (risk aversion), which necessarily prolongs processing time, and they also show the well-documented general decline in sensory and/or motor functions. KW - numerical comparison KW - cognitive aging effects KW - numerical distance effect KW - random walk model KW - speed-accuracy trade-off Y1 - 2019 U6 - https://doi.org/10.1037/pag0000272 SN - 0882-7974 SN - 1939-1498 VL - 34 IS - 1 SP - 4 EP - 16 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Langhammer, Maria A1 - Thober, Jule A1 - Lange, Martin A1 - Frank, Karin A1 - Grimm, Volker T1 - Agricultural landscape generators for simulation models BT - a review of existing solutions and an outline of future directions JF - Ecological modelling : international journal on ecological modelling and engineering and systems ecolog N2 - There is an increasing need for an assessment of the impacts of land use and land use change (LUCC). In this context, simulation models are valuable tools for investigating the impacts of stakeholder actions or policy decisions. Agricultural landscape generators (ALGs), which systematically and automatically generate realistic but simplified representations of land cover in agricultural landscapes, can provide the input for LUCC models. We reviewed existing ALGs in terms of their objectives, design and scope. We found eight ALGs that met our definition. They were based either on generic mathematical algorithms (pattern-based) or on representations of ecological or land use processes (process-based). Most ALGs integrate only a few landscape metrics, which limits the design of the landscape pattern and thus the range of applications. For example, only a few specific farming systems have been implemented. We conclude that existing ALGs contain useful approaches that can be used for specific purposes, but ideally generic modular ALGs are developed that can be used for a wide range of scenarios, regions and model types. We have compiled features of such generic ALGs and propose a possible software architecture. Considerable joint efforts are required to develop such generic ALGs, but the benefits in terms of a better understanding and development of more efficient agricultural policies would be high. KW - Agricultural landscape KW - Field pattern KW - Agricultural landscape generator KW - Landscape simulator KW - Neutral landscape model KW - Process-based model Y1 - 2019 U6 - https://doi.org/10.1016/j.ecolmodel.2018.12.010 SN - 0304-3800 SN - 1872-7026 VL - 393 SP - 135 EP - 151 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Jeglinski-Mende, Melinda A. T1 - Alcohol in the Aging Brain BT - The Interplay Between Alcohol Consumption, Cognitive Decline and the Cardiovascular System T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - As our society grows older new challenges for medicine and healthcare emerge. Agerelated changes of the body have been observed in essential body functions, particularly in the loco-motor system, in the cardiovascular system and in cognitive functions concerning both brain plasticity and changes in behavior. Nutrition and lifestyle, such as nicotine intake and chronic alcohol consumption, also contribute to biological changes in the brain. This review addresses the effect of alcohol consumption on cognitive decline, changes in brain plasticity in the aging brain and on cardiovascular health in aging. Thus, studies on the interplay of chronic alcohol intake and either cognitive decline or cognitive preservation are outlined. Because of the inconsistency in the literature of whether alcohol consumption preserves cognitive functions in the aging brain or whether it accelerates cognitive decline, it is crucial to consider individual contributing factors such as culture, health and lifestyle in future studies. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 566 KW - cognitive decline KW - neuroplasticity KW - AUD KW - alcohol consumption KW - aging brain Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-436568 SN - 1866-8364 IS - 566 ER - TY - JOUR A1 - Jeglinski-Mende, Melinda A. T1 - Alcohol in the Aging Brain BT - The Interplay Between Alcohol Consumption, Cognitive Decline and the Cardiovascular System JF - Frontiers in Neuroscience N2 - As our society grows older new challenges for medicine and healthcare emerge. Agerelated changes of the body have been observed in essential body functions, particularly in the loco-motor system, in the cardiovascular system and in cognitive functions concerning both brain plasticity and changes in behavior. Nutrition and lifestyle, such as nicotine intake and chronic alcohol consumption, also contribute to biological changes in the brain. This review addresses the effect of alcohol consumption on cognitive decline, changes in brain plasticity in the aging brain and on cardiovascular health in aging. Thus, studies on the interplay of chronic alcohol intake and either cognitive decline or cognitive preservation are outlined. Because of the inconsistency in the literature of whether alcohol consumption preserves cognitive functions in the aging brain or whether it accelerates cognitive decline, it is crucial to consider individual contributing factors such as culture, health and lifestyle in future studies. KW - cognitive decline KW - neuroplasticity KW - AUD KW - alcohol consumption KW - aging brain Y1 - 2019 U6 - https://doi.org/10.3389/fnins.2019.00713 SN - 1662-453X SN - 1662-4548 VL - 13 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Jeglinski-Mende, Melinda A. T1 - Alcohol in the aging brain BT - the interplay between alcohol consumption, cognitive decline and the cardiovascular system JF - Frontiers in neuroscience N2 - As our society grows older new challenges for medicine and healthcare emerge. Age-related changes of the body have been observed in essential body functions, particularly in the loco-motor system, in the cardiovascular system and in cognitive functions concerning both brain plasticity and changes in behavior. Nutrition and lifestyle, such as nicotine intake and chronic alcohol consumption, also contribute to biological changes in the brain. This review addresses the effect of alcohol consumption on cognitive decline, changes in brain plasticity in the aging brain and on cardiovascular health in aging. Thus, studies on the interplay of chronic alcohol intake and either cognitive decline or cognitive preservation are outlined. Because of the inconsistency in the literature of whether alcohol consumption preserves cognitive functions in the aging brain or whether it accelerates cognitive decline, it is crucial to consider individual contributing factors such as culture, health and lifestyle in future studies. KW - cognitive decline KW - neuroplasticity KW - AUD KW - alcohol consumption KW - aging brain Y1 - 2019 U6 - https://doi.org/10.3389/fnins.2019.00713 SN - 1662-453X VL - 13 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Vishnevetskaya, Natalya S. A1 - Hildebrand, Viet A1 - Nizardo, Noverra Mardhatillah A1 - Ko, Chia-Hsin A1 - Di, Zhenyu A1 - Radulescu, Aurel A1 - Barnsley, Lester C. A1 - Müller-Buschbaum, Peter A1 - Laschewsky, André A1 - Papadakis, Christine M. T1 - All-in-One "Schizophrenic" self-assembly of orthogonally tuned thermoresponsive diblock copolymers JF - Langmuir N2 - Smart, fully orthogonal switching was realized in a highly biocompatible diblock copolymer system with variable trigger-induced aqueous self-assembly. The polymers are composed of nonionic and zwitterionic blocks featuring lower and upper critical solution temperatures (LCSTs and UCSTs). In the system investigated, diblock copolymers from poly(N-isopropyl methacrylamide) (PNIPMAM) and a poly(sulfobetaine methacrylamide), systematic variation of the molar mass of the latter block allowed for shifting the UCST of the latter above the LCST of the PNIPMAM block in a salt-free condition. Thus, successive thermal switching results in "schizophrenic" micellization, in which the roles of the hydrophobic core block and the hydrophilic shell block are interchanged depending on the temperature. Furthermore, by virtue of the strong electrolyte-sensitivity of the zwitterionic polysulfobetaine block, we succeeded to shift its UCST below the LCST of the PNIPMAM block by adding small amounts of an electrolyte, thus inverting the pathway of switching. This superimposed orthogonal switching by electrolyte addition enabled us to control the switching scenarios between the two types of micelles (i) via an insoluble state, if the LCST-type cloud point is below the UCST-type cloud point, which is the case at low salt concentrations or (ii) via a molecularly dissolved state, if the LCST-type cloud point is above the UCST-type cloud point, which is the case at high salt concentrations. Systematic variation of the block lengths allowed for verifying the anticipated behavior and identifying the molecular architecture needed. The versatile and tunable self-assembly offers manifold opportunities, for example, for smart emulsifiers or for sophisticated carrier systems. Y1 - 2019 U6 - https://doi.org/10.1021/acs.langmuir.9b00241 SN - 0743-7463 VL - 35 IS - 19 SP - 6441 EP - 6452 PB - American Chemical Society CY - Washington ER - TY - GEN A1 - Tofelde, Stefanie A1 - Savi, Sara A1 - Wickert, Andrew D. A1 - Bufe, Aaron A1 - Schildgen, Taylor F. T1 - Alluvial channel response to environmental perturbations BT - fill-terrace formation and sediment-signal disruption T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - The sensitivity of fluvial systems to tectonic and climatic boundary conditions allows us to use the geomorphic and stratigraphic records as quantitative archives of past climatic and tectonic conditions. Thus, fluvial terraces that form on alluvial fans and floodplains as well as the rate of sediment export to oceanic and continental basins are commonly used to reconstruct paleoenvironments. However, we currently lack a systematic and quantitative understanding of the transient evolution of fluvial systems and their associated sediment storage and release in response to changes in base level, water input, and sediment input. Such knowledge is necessary to quantify past environmental change from terrace records or sedimentary deposits and to disentangle the multiple possible causes for terrace formation and sediment deposition. Here, we use a set of seven physical experiments to explore terrace formation and sediment export from a single, braided channel that is perturbed by changes in upstream water discharge or sediment supply, or through downstream base-level fall. Each perturbation differently affects (1) the geometry of terraces and channels, (2) the timing of terrace cutting, and (3) the transient response of sediment export from the basin. In general, an increase in water discharge leads to near-instantaneous channel incision across the entire fluvial system and consequent local terrace cutting, thus preserving the initial channel slope on terrace surfaces, and it also produces a transient increase in sediment export from the system. In contrast, a decreased upstream sediment-supply rate may result in longer lag times before terrace cutting, leading to terrace slopes that differ from the initial channel slope, and also lagged responses in sediment export. Finally, downstream base-level fall triggers the upstream propagation of a diffuse knickzone, forming terraces with upstream-decreasing ages. The slope of terraces triggered by base-level fall mimics that of the newly adjusted active channel, whereas slopes of terraces triggered by a decrease in upstream sediment discharge or an increase in upstream water discharge are steeper compared to the new equilibrium channel. By combining fillterrace records with constraints on sediment export, we can distinguish among environmental perturbations that would otherwise remain unresolved when using just one of these records. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 762 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437185 SN - 1866-8372 IS - 762 SP - 609 EP - 631 ER - TY - JOUR A1 - Tofelde, Stefanie A1 - Savi, Sara A1 - Wickert, Andrew D. A1 - Bufe, Aaron A1 - Schildgen, Taylor F. T1 - Alluvial channel response to environmental perturbations BT - fill-terrace formation and sediment-signal disruption JF - Earth Surface Dynamics N2 - The sensitivity of fluvial systems to tectonic and climatic boundary conditions allows us to use the geomorphic and stratigraphic records as quantitative archives of past climatic and tectonic conditions. Thus, fluvial terraces that form on alluvial fans and floodplains as well as the rate of sediment export to oceanic and continental basins are commonly used to reconstruct paleoenvironments. However, we currently lack a systematic and quantitative understanding of the transient evolution of fluvial systems and their associated sediment storage and release in response to changes in base level, water input, and sediment input. Such knowledge is necessary to quantify past environmental change from terrace records or sedimentary deposits and to disentangle the multiple possible causes for terrace formation and sediment deposition. Here, we use a set of seven physical experiments to explore terrace formation and sediment export from a single, braided channel that is perturbed by changes in upstream water discharge or sediment supply, or through downstream base-level fall. Each perturbation differently affects (1) the geometry of terraces and channels, (2) the timing of terrace cutting, and (3) the transient response of sediment export from the basin. In general, an increase in water discharge leads to near-instantaneous channel incision across the entire fluvial system and consequent local terrace cutting, thus preserving the initial channel slope on terrace surfaces, and it also produces a transient increase in sediment export from the system. In contrast, a decreased upstream sediment-supply rate may result in longer lag times before terrace cutting, leading to terrace slopes that differ from the initial channel slope, and also lagged responses in sediment export. Finally, downstream base-level fall triggers the upstream propagation of a diffuse knickzone, forming terraces with upstream-decreasing ages. The slope of terraces triggered by base-level fall mimics that of the newly adjusted active channel, whereas slopes of terraces triggered by a decrease in upstream sediment discharge or an increase in upstream water discharge are steeper compared to the new equilibrium channel. By combining fillterrace records with constraints on sediment export, we can distinguish among environmental perturbations that would otherwise remain unresolved when using just one of these records. Y1 - 2019 U6 - https://doi.org/10.5194/esurf-7-609-2019 SN - 2196-6311 SN - 2196-632X VL - 7 SP - 609 EP - 631 PB - Copernicus Publ. CY - Göttingen ER - TY - GEN A1 - Heinicker, Paul A1 - Likavcan, Lukas A1 - Lin, Qiao T1 - alt'ai: designing machine-to-machine interfaces for automated landscapes N2 - alt'ai is an agent-based simulation inspired by aesthetics, culture and environmental conditions of the Altai mountain region on the borders between Russia, Kazakhstan, China and Mongolia. It is set into a scenario of a remote automated landscape populated by sentient machines, where biological species, machines and environments autonomously interact to produce unforeseeable visual outputs. It poses a question of designing future machine-to-machine authentication protocols that are based on the use of images encoding agent behavior. Also, the simulation provides rich visual perspective on this challenge. The project pleads for a heavily aestheticized approach to design practice and highlights the importance of productively inefficient and information redundant systems. Y1 - 2019 SN - 978-1-4503-6311-2 U6 - https://doi.org/10.1145/3306211.3320146 PB - Association for Computing Machinery CY - New York ER - TY - GEN A1 - Wippert, Pia-Maria A1 - Block, Andrea A1 - Mansuy, Isabelle M. A1 - Peters, Eva M. J. A1 - Rose, Matthias A1 - Rapp, Michael Armin A1 - Huppertz, Alexander A1 - Würtz-Kozak, Karin T1 - Alterations in Bone Homeostasis and Microstructure Related to Depression and Allostatic Load T2 - Psychotherapy and Psychosomatics Y1 - 2019 U6 - https://doi.org/10.1159/000503640 SN - 0033-3190 SN - 1423-0348 VL - 88 IS - 6 SP - 383 EP - 385 PB - Karger CY - Basel ER - TY - JOUR A1 - Schröter, David A1 - Neugart, Susanne A1 - Schreiner, Monika A1 - Grune, Tilman A1 - Rohn, Sascha A1 - Ott, Christiane T1 - Amaranth’s 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages JF - Nutrients N2 - For centuries, Amaranthus sp. were used as food, ornamentals, and medication. Molecular mechanisms, explaining the health beneficial properties of amaranth, are not yet understood, but have been attributed to secondary metabolites, such as phenolic compounds. One of the most abundant phenolic compounds in amaranth leaves is 2-caffeoylisocitric acid (C-IA) and regarding food occurrence, C-IA is exclusively found in various amaranth species. In the present study, the anti-inflammatory activity of C-IA, chlorogenic acid, and caffeic acid in LPS-challenged macrophages (RAW 264.7) has been investigated and cellular contents of the caffeic acid derivatives (CADs) were quantified in the cells and media. The CADs were quantified in the cell lysates in nanomolar concentrations, indicating a cellular uptake. Treatment of LPS-challenged RAW 264.7 cells with 10 µM of CADs counteracted the LPS effects and led to significantly lower mRNA and protein levels of inducible nitric oxide synthase, tumor necrosis factor alpha, and interleukin 6, by directly decreasing the translocation of the nuclear factor κB/Rel-like containing protein 65 into the nucleus. This work provides new insights into the molecular mechanisms that attribute to amaranth’s anti-inflammatory properties and highlights C-IA’s potential as a health-beneficial compound for future research. KW - inflammation KW - caffeic acid derivatives KW - RAW 264 KW - 7 macrophages KW - NF-kappa B KW - amaranth Y1 - 2019 U6 - https://doi.org/10.3390/nu11030571 SN - 2072-6643 VL - 11 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Naolou, Toufik A1 - Lendlein, Andreas A1 - Neffe, Axel T. T1 - Amides as non-polymerizable catalytic adjuncts enable the ring-opening polymerization of lactide with ferrous acetate under mild conditions JF - Frontiers in Chemistry N2 - Sn-based catalysts are effective in the ring-opening polymerization (ROP) but are toxic. Fe(OAc)(2) used as an alternative catalyst is suitable for the ROP of lactide only at higher temperatures (>170 degrees C), associated with racemization. In the ROP of ester and amide group containing morpholinediones with Fe(OAc)(2) to polydepsipeptides at 135 degrees C, ester bonds were selectively opened. Here, it was hypothesized that ROP of lactones is possible with Fe(OAc)(2) when amides are present in the reactions mixture as Fe-ligands could increase the solubility and activity of the metal catalytic center. The ROP of lactide in the melt with Fe(OAc)(2) is possible at temperatures as low as 105 degrees C, in the presence of N-ethylacetamide or N-rnethylbenzamide as non-polymerizable catalytic adjuncts (NPCA), with high conversion (up to 99 mol%) and yield (up to 88 mol%). Polydispersities of polylactide decreased with decreasing reaction temperature to <= 1.1. NMR as well as polarimetric studies showed that no racemization occurred at reaction temperatures <= 145 degrees C. A kinetic study demonstrated a living chain-growth mechanism. MALDI analysis revealed that no side reactions (e.g., cyclization) occurred, though transesterification took place. KW - ring-opening polymerization KW - polyester KW - catalyst KW - iron KW - amide ligand Y1 - 2019 U6 - https://doi.org/10.3389/fchem.2019.00346 SN - 2296-2646 VL - 7 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Aloni, Sapir Shekef A1 - Perovic, Milena A1 - Weitman, Michal A1 - Cohen, Reut A1 - Oschatz, Martin A1 - Mastai, Yitzhak T1 - Amino acid-based ionic liquids as precursors for the synthesis of chiral nanoporous carbons JF - Nanoscale Advances N2 - The synthesis of chiral nanoporous carbons based on chiral ionic liquids (CILs) of amino acids as precursors is described. Such unique precursors for the carbonization of CILs yield chiral carbonaceous materials with high surface area (approximate to 620 m(2) g(-1)). The enantioselectivities of the porous carbons are examined by advanced techniques such as selective adsorption of enantiomers using cyclic voltammetry, isothermal titration calorimetry, and mass spectrometry. These techniques demonstrate the chiral nature and high enantioselectivity of the chiral carbon materials. Overall, we believe that the novel approach presented here can contribute significantly to the development of new chiral carbon materials that will find important applications in chiral chemistry, such as in chiral catalysis and separation and in chiral sensors. From a scientific point of view, the approach and results reported here can significantly deepen our understanding of chirality at the nanoscale and of the structure and nature of chiral nonporous materials and surfaces. Y1 - 2019 U6 - https://doi.org/10.1039/c9na00520j SN - 2516-0230 VL - 1 IS - 12 SP - 4981 EP - 4988 PB - Royal Society of Chemistry CY - Cambridge ER - TY - THES A1 - Nagel, Oliver T1 - Amoeboid cells as a transport system for micro-objects T1 - Amöboide Zellen als Transportsystem für Mikroobjekte N2 - Due to advances in science and technology towards smaller and more powerful processing units, the fabrication of micrometer sized machines for different tasks becomes more and more possible. Such micro-robots could revolutionize medical treatment of diseases and shall support to work on other small machines. Nevertheless, scaling down robots and other devices is a challenging task and will probably remain limited in near future. Over the past decade the concept of bio-hybrid systems has proved to be a promising approach in order to advance the further development of micro-robots. Bio-hybrid systems combine biological cells with artificial components, thereby benefiting from the functionality of living biological cells. Cell-driven micro-transport is one of the most prominent applications in the emerging field of these systems. So far, micrometer sized cargo has been successfully transported by means of swimming bacterial cells. The potential of motile adherent cells as transport systems has largely remained unexplored. This thesis concentrates on the social amoeba Dictyostelium discoideum as a potential candidate for an amoeboid bio-hybrid transport system. The use of this model organism comes with several advantages. Due to the unspecific properties of Dictyostelium adhesion, a wide range of different cargo materials can be used for transport. As amoeboid cells exceed bacterial cells in size by one order of magnitude, also the size of an object carried by a single cell can also be much larger for an amoeba. Finally it is possible to guide the cell-driven transport based on the chemotactic behavior of the amoeba. Since cells undergo a developmentally induced chemotactic aggregation, cargo could be assembled in a self-organized manner into a cluster. It is also possible to impose an external chemical gradient to guide the amoeboid transport system to a desired location. To establish Dictyostelium discoideum as a possible candidate for bio-hybrid transport systems, this thesis will first investigate the movement of single cells. Secondly, the interaction of cargo and cells will be studied. Eventually, a conceptional proof will be conducted, that the cheomtactic behavior can be exploited either to transport a cargo self-organized or through an external chemical source. N2 - Durch die Fortschritte in Wissenschaft und Technik hin zu kleineren und leistungsfähigeren Prozessoren wird die Herstellung von Maschinen mit einer Größe von wenigen Mikrometern immer wahrscheinlicher. Solche Mikro-Roboter könnten sowohl die medizinische Behandlung von Krankheiten revolutionieren als auch dabei helfen andere kleine Maschinen zu bauen. Nichts desto trotz ist es eine komplizierte Aufgabe Roboter sowie andere Maschinen zu verkleinern und wird in naher Zukunft wohl nur begrenzt möglich sein. Im Verlauf des letzten Jahrzehnts hat sich das Konzept der Bio-Hybridsysteme als ein vielversprechender Ansatz entwickelt, um Mikro-Roboter weiter zu entwickeln. Bio-Hybridsysteme kombinieren biologische Zellen mit künstlichen Komponenten, um so einen Vorteil aus der Funktionalität lebender biologischer Zellen zu ziehen. Der zellgetriebene Mikro-Transport ist eine der bekanntesten Anwendungen in dem wachsenden Feld dieser Systeme. Bisher wurde mikrometergroße Fracht erfolgreich mit Hilfe von schwimmenden Bakterien transportiert. Das Potential beweglicher, adhärenter Zellen als Transportsystem blieb bisher weitgehend unerforscht. Diese Arbeit beschäftigt sich mit der sozialen Amöbe Dictyostelium discoideum als einen potentiellen Kandidaten für ein auf Amöben basiertes Bio-Hybridtransportsystem. Die Nutzung dieses Modellorganismus bringt einige Vorteile mit sich. Auf Grund der unspezifischen Adhäsion von Dictyostelium ist es möglich eine Vielzahl von verschiedenen Frachtmaterialien für den Transport zu nutzen. Da Amöben um eine Größenordnung größer sind als Bakterien, können auch die Objekte, die eine einzelne Amöbe transportieren kann um einiges größer sein, als bei einer einzelnen Bakterie. Desweiteren ist noch möglich den zellgetrieben Transport durch das chemotaktische Verhalten der Amöben zu steuern. Da die Zellen im Verlauf ihres Lebenszyklus’ eine entwicklungsinduzierte chemotaktische Aggregation durchlaufen, ist es möglich, die Fracht in einer selbstorganisierten Art und Weise in Aggregate zusammen zu führen. Es ist auch möglich einen externen chemotaktischen Stimulus zu generieren, um das auf Amöben basierende Transportsystem zu einer gewünschten Position zu lenken. Um Dictyostelium discoideum als denkbaren Kandidaten für ein Bio-Hybridtransportsystem zu etablieren, wird in dieser Arbeit zuerst die Bewegung einzelner Zellen untersucht. Als zweites wird die Interaktion von Zellen und Fracht studiert. Zum Schluss wird ein konzeptioneller Beweis geführt, dass das chemotaktische Verhalten der Zellen genutzt werden kann, um eine Fracht entweder selbstorganisiert oder mit Hilfe eines externen Stimulus zu transportieren. KW - bio-hybrid KW - dicytostelium KW - chemotaxsis KW - Bio-Hybrid KW - Dicytostelium KW - Chemotaxsis Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442192 ER - TY - JOUR A1 - Heck, Christian A1 - Kanehira, Yuya A1 - Kneipp, Janina A1 - Bald, Ilko T1 - Amorphous Carbon Generation as a Photocatalytic Reaction on DNA-Assembled Gold and Silver Nanostructures JF - Molecules N2 - Background signals from in situ-formed amorphous carbon, despite not being fully understood, are known to be a common issue in few-molecule surface-enhanced Raman scattering (SERS). Here, discrete gold and silver nanoparticle aggregates assembled by DNA origami were used to study the conditions for the formation of amorphous carbon during SERS measurements. Gold and silver dimers were exposed to laser light of varied power densities and wavelengths. Amorphous carbon prevalently formed on silver aggregates and at high power densities. Time-resolved measurements enabled us to follow the formation of amorphous carbon. Silver nanolenses consisting of three differently-sized silver nanoparticles were used to follow the generation of amorphous carbon at the single-nanostructure level. This allowed observation of the many sharp peaks that constitute the broad amorphous carbon signal found in ensemble measurements. In conclusion, we highlight strategies to prevent amorphous carbon formation, especially for DNA-assembled SERS substrates. KW - amorphous carbon KW - DNA origami KW - SERS KW - nanoparticle dimers KW - nanolenses Y1 - 2019 U6 - https://doi.org/10.3390/molecules24122324 SN - 1420-3049 VL - 24 IS - 12 PB - MDPI CY - Basel ER - TY - GEN A1 - Heck, Christian A1 - Kanehira, Yuya A1 - Kneipp, Janina A1 - Bald, Ilko T1 - Amorphous Carbon Generation as a Photocatalytic Reaction on DNA-Assembled Gold and Silver Nanostructures T2 - Mathematisch-Naturwissenschaftliche Reihe N2 - Background signals from in situ-formed amorphous carbon, despite not being fully understood, are known to be a common issue in few-molecule surface-enhanced Raman scattering (SERS). Here, discrete gold and silver nanoparticle aggregates assembled by DNA origami were used to study the conditions for the formation of amorphous carbon during SERS measurements. Gold and silver dimers were exposed to laser light of varied power densities and wavelengths. Amorphous carbon prevalently formed on silver aggregates and at high power densities. Time-resolved measurements enabled us to follow the formation of amorphous carbon. Silver nanolenses consisting of three differently-sized silver nanoparticles were used to follow the generation of amorphous carbon at the single-nanostructure level. This allowed observation of the many sharp peaks that constitute the broad amorphous carbon signal found in ensemble measurements. In conclusion, we highlight strategies to prevent amorphous carbon formation, especially for DNA-assembled SERS substrates. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 732 KW - amorphous carbon KW - DNA origami KW - SERS KW - nanoparticle dimers KW - nanolenses Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-430812 SN - 1866-8372 IS - 732 ER - TY - JOUR A1 - Lorenz, Robert C. A1 - Matthias, Katja A1 - Pieper, Dawid A1 - Wegewitz, Uta A1 - Morche, Johannes A1 - Nocon, Marc A1 - Rissling, Olesja A1 - Schirm, Jacqueline A1 - Freitag, Simone A1 - Jacobs, Anja T1 - AMSTAR 2 overall confidence rating BT - lacking discriminating capacity or requirement of high methodological quality? JF - Journal of clinical epidemiology : including pharmacoepidemiology reports Y1 - 2019 U6 - https://doi.org/10.1016/j.jclinepi.2019.10.006 SN - 0895-4356 SN - 1878-5921 VL - 119 SP - 142 EP - 144 PB - Elsevier CY - New York ER - TY - THES A1 - Brigard Torres, Juan Camilo T1 - An aesthetic cartography of fast T1 - Eine ästhetische Kartographie des aktiven Hungers BT - Gandhi and the hunger artists BT - Gandhis Fasten und die Hungerkünstler*innen N2 - In this cartography, I examine M.K. Gandhi’s practice of fasting for political purposes from a specifically aesthetic perspective. In other words, to foreground their dramatic qualities, how they in their expressive repetition, patterning and stylization produced a/effected heightened forms of emotions. To carry out this task, I follow the theater scholar Erika Fischer-Lichte’s features that give name to her book Äesthetik des Performativen (2004). The cartography is framed in a philosophical presentation of Gandhi’s discourse as well as of his historical sources. Moreover, as a second frame, I historicize the fasts, by means of a typology and teleology in context. The historically and discoursively framed cartography maps four main dimensions that define the aesthetics of the performative: mediality, materiality, semioticity and aestheticity. The first part analyses the medial platforms in which the fasts as events have been historically recorded and in which they have left their traces and inscriptions. These historical sources are namely, newspapers, images, newsreels and a documentary film. Secondly, the material dimension depicts Gandhi’s corporeal condition, as well as the spatiality and temporality of the fasts. In the third place, I revise and reformulate critically Fischer-Lichte’s concepts of “presence” and “representation” with resonating concepts of G. C. Spivak and J. Rancière. This revision illustrates Gandhi’s fasts and shows the process of how an individual may become the embodiment or representation of a national body-politic. The last chapter of the cartography explores the autopoetic-feedback loop between Gandhi and the people and finishes with a comparison of the mise en scène of the hunger artists with the fasts of the Indian the politician, social reformer, and theologian. The text concludes interpreting Gandhi’s practice of fasting under the light of the concepts of “intellectual emancipation” and “de-subjectivation” of the philosopher J. Rancière. The four main concerns of this cartography are: Firstly, in the field of Gandhi’s reception, to explore the aesthetic dimension as both alternative and complementary to the two hegemonic interpretative lenses, i.e. a hagiographic or a secular political understanding of the fasts. From a theoretical perspective, the cartography pursues to be a transdisciplinary experiment that aims at deploying concepts that have been traditionally developed, derived from and used in the field of the arts (theater, film, literature, aesthetic performance, etc.) in the field of the political. In brief, inverting an expression of Rancière, to understand politics as aesthetics. Thirdly, from a thematic point of view, the cartography inquires the historical forms of staging and perception of hunger. Last yet importantly, it is an inquiry of the practice of fasting as nonviolence, what Gandhi, its most sophisticated modern theoretician and practitioner considered its most radical expression. N2 - Die Masterarbeit betrachtet M.K. Gandhis politische Ausübung des Fastens aus einer ästhetischen Perspektive. Im Fokus stehen dabei die dramatischen Eigenschaften dieser asketischen Praxis: Von besonderem Interesse sind expressive Wiederholungen, Gestaltungen und Stilisierungen, die Affekte auslösen. Die Analyse greift auf Begriffe und Theorien von Erika Fischer-Lichtes Ästhetik des Performativen (2004) zurück, um damit die ästhetische Dimension von Gandhis Fasten zu beleuchten. Eine historische und philosophische Kontextualisierung rahmt die ästhetische Kartographie ein. Die Analyse untergliedert sich in vier verschiedene Sphären: Medialität, Materialität, Semiotizität und Ästhetizität. Den Beginn macht eine Untersuchung von medialen Plattformen in den bereits historisierten Spuren der Ereignisse. Als historische Quellen dienen Zeitungsartikel, Fotos, die Wochenschau (newsreel) und ein Dokumentarfilm. Die Sphäre der Materialität wird im Anschluss durch die folgenden Kriterien analysiert: den körperlichen Zustand Gandhis, die Temporalität und die Räumlichkeit des Fastens. Zudem beschäftigt sich der Text mit der Konfiguration von Bedeutung durch eine theoretische Überarbeitung der von Fischer-Lichte geprägten Begriffe von „Präsenz“ und „Repräsentation“. Die Grundlage für diese Überarbeitung sind Texte von J. Rancière und G. C. Spivak. Die Überarbeitung soll mit Beispielen von Gandhis Fasten illustriert werden, um zu zeigen, wie ein individueller Mensch zur Verkörperung oder Repräsentation einer Nation werden kann. Zuletzt nimmt die Analyse der ästhetischen Sphäre die autopoietische Feedback-Schleife zwischen Gandhi und dem Volk in den Blick. Zudem vergleicht die Studie die Inszenierungsformen von Gandhis Fasten und die von den Hungerkünstlern*innen im Westen. Der Abschluss der Masterarbeit verbindet Gandhis Fasten als Ritual mit den von Jacques Rancière entwickelten Begriffen der intellektuellen Emanzipation und der De-Subjektivierung. KW - fasting KW - Gandhi KW - performance KW - aesthetics KW - Hunger KW - Fasten KW - Gandhi KW - Performance KW - Ästhetik KW - hunger Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469333 ER - TY - JOUR A1 - Clavier, Pierre J. A1 - Guo, Li A1 - Paycha, Sylvie A1 - Zhang, Bin T1 - An algebraic formulation of the locality principle in renormalisation JF - European Journal of Mathematics N2 - We study the mathematical structure underlying the concept of locality which lies at the heart of classical and quantum field theory, and develop a machinery used to preserve locality during the renormalisation procedure. Viewing renormalisation in the framework of Connes and Kreimer as the algebraic Birkhoff factorisation of characters on a Hopf algebra with values in a Rota-Baxter algebra, we build locality variants of these algebraic structures, leading to a locality variant of the algebraic Birkhoff factorisation. This provides an algebraic formulation of the conservation of locality while renormalising. As an application in the context of the Euler-Maclaurin formula on lattice cones, we renormalise the exponential generating function which sums over the lattice points in a lattice cone. As a consequence, for a suitable multivariate regularisation, renormalisation from the algebraic Birkhoff factorisation amounts to composition by a projection onto holomorphic multivariate germs. KW - Locality KW - Renormalisation KW - Algebraic Birkhoff factorisation KW - Partial algebra KW - Hopf algebra KW - Rota-Baxter algebra KW - Multivariate meromorphic functions KW - Lattice cones Y1 - 2019 U6 - https://doi.org/10.1007/s40879-018-0255-8 SN - 2199-675X SN - 2199-6768 VL - 5 IS - 2 SP - 356 EP - 394 PB - Springer CY - Cham ER - TY - JOUR A1 - Haider, Hubert T1 - An anthropic principle in lieu of a “Universal Grammar” JF - Of trees and birds. A Festschrift for Gisbert Fanselow KW - Festschrift KW - Informationsstruktur KW - Linguistik KW - Morphologie KW - Syntax KW - festschrift KW - information structure KW - linguistics KW - morphology KW - syntax Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-432590 SN - 978-3-86956-457-9 SP - 363 EP - 381 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Dreher, Dorothee A1 - Baldermann, Susanne A1 - Schreiner, Monika A1 - Hause, Bettina T1 - An arbuscular mycorrhizal fungus and a root pathogen induce different volatiles emitted by Medicago truncatula roots JF - Journal of Advanced Research N2 - Plants are in permanent contact with various microorganisms and are always impacted by them. To better understand the first steps of a plant’s recognition of soil-borne microorganisms, the early release of volatile organic compounds (VOCs) emitted from roots of Medicago truncatula in response to the symbiont Rhizophagus irregularis or the pathogenic oomycete Aphanomyces euteiches was analysed. More than 90 compounds were released from roots as detected by an untargeted gas chromatography-mass spectrometry approach. Principal component analyses clearly distinguished untreated roots from roots treated with either R. irregularis or A. euteiches. Several VOCs were found to be emitted specifically in response to each of the microorganisms. Limonene was specifically emitted from wild-type roots after contact with R. irregularis spores but not from roots of the mycorrhiza-deficient mutant does not make infections3. The application of limonene to mycorrhizal roots, however, did not affect the mycorrhization rate. Inoculation of roots with A. euteiches zoospores resulted in the specific emission of several sesquiterpenes, such as nerolidol, viridiflorol and nerolidol-epoxyacetate but application of nerolidol to zoospores of A. euteiches did not affect their vitality. Therefore, plants discriminate between different microorganisms at early stages of their interaction and respond differently to the level of root-emitted volatiles. KW - Arbuscular mycorrhiza KW - Oomycetous pathogen KW - Volatile organic compound (VOC) KW - Aeroponic cultivation KW - Gas chromatography-mass spectrometry (GC-MS) Y1 - 2019 U6 - https://doi.org/10.1016/j.jare.2019.03.002 SN - 2090-1232 SN - 2090-1224 VL - 19 SP - 85 EP - 90 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Hudson, Paul A1 - De Ruig, Lars T. A1 - De Ruiter, Marco C. A1 - Kuik, Onno J. A1 - Botzen, W. J. Wouter A1 - Le Den, X. A1 - Persson, Magnus A1 - Benoist, Anthony A1 - Nielsen, C. N. T1 - An assessment of best practices of extreme weather insurance and directions for a more resilient society T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - Extreme weather resilience has been defined as being based on three pillars: resistance (the ability to lower impacts), recovery (the ability to bounce back), and adaptive capacity (the ability to learn and improve). These resilience pillars are important both before and after the occurrence of extreme weather events. Extreme weather insurance can influence these pillars of resilience depending on how particular insurance mechanisms are structured. We explore how the lessons learnt from the current best insurance practices can improve resilience to extreme weather events. We employ an extensive inventory of private property and agricultural crop insurance mechanisms to conduct a multi-criteria analysis of insurance market outcomes. We draw conclusions regarding the patterns in the best practice from six European countries to increase resilience. We suggest that requirements to buy a bundle extreme weather event insurance with general insurance packages are strengthened and supported with structures to financing losses through public-private partnerships. Moreover, support for low income households through income vouchers could be provided. Similarly, for the agricultural sector we propose moving towards comprehensive crop yield insurance linked to general agricultural subsidies. In both cases a nationally representative body can coordinate the various stakeholders into acting in concert. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 757 KW - extreme weather KW - insurance KW - resilience KW - climate change adaptation KW - risk management Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433510 SN - 1866-8372 IS - 757 ER - TY - JOUR A1 - Platz, Anna A1 - Weckmann, Ute T1 - An automated new pre-selection tool for noisy Magnetotelluric data using the Mahalanobis distance and magnetic field constraints JF - Geophysical journal international N2 - In Magnetotellurics (MT) natural electromagnetic field variations are recorded to study the electrical conductivity structure of the subsurface. Thereby long time-series of electromagnetic data are subdivided into smaller segments, which are Fourier transformed and typically averaged in a statistically robust manner to obtain MT transfer functions. Unfortunately, nowadays the presence of man-made electromagnetic noise sources often deteriorates a significant fraction of the recorded time-series by overprinting the desired natural field variations. Available approaches to obtain undisturbed and high quality MT results include, for example robust statistics, remote reference or multi-station analyses which aim at the removal of outliers or uncorrelated noise. However, we have observed that intermittent noise often affects a certain time span resulting in a second cluster of transfer functions in addition to the expected true MT distribution. In this paper, we present a novel criterion for the detection and pre-selection of EM noise in form of outliers or additional clusters based on a distance measure of each data segment with regard to the centre of the data distribution. For this purpose, we utilize the Mahalanobis distance (MD) which computes the distance between two multivariate points considering the covariance matrix of the data that quantifies the shape and the size of multivariate data distributions. As the MD considers the covariance matrix, it corrects not only for different variances but also for any correlation between the data. The computation of both, the mean value and covariance matrix, is susceptible to ouliers (e.g. noise) and requires a statistically robust estimation. We tested several robust estimators, for example median absolute deviation or minimum covariance determinant algorithm and finally implemented an automatic criterion using a deterministic minimum covariance determinant algorithm. We will present results using MT data from various field experiments all over the world, which illustrate successfull data improvement. This approach is able to remove scattered data points as well as to reject complete data cluster originating from noise sources. However, like all purely statistical algorithms the criterion is limited to cases where the majority of the recorded data is well-behaved, that is noise content is below 50 per cent. If the majority of data points originates from noise sources, the new criterion will fail if used in an automatic way. In these cases, additional input by the user either manually or in an automated fashion can be utilized. We therefore suggest to use an add-on criterion to back the MD selection and subsequent robust stacking in form of a physically motivated constraint based on the magnetic incidence direction. This property indicates whether the magnetic field originates from various sources in the far field or from a strong and well defined source in the near field. KW - Magnetotellurics KW - Statistical methods KW - Time-series analysis Y1 - 2019 U6 - https://doi.org/10.1093/gji/ggz197 SN - 0956-540X SN - 1365-246X VL - 218 IS - 3 SP - 1853 EP - 1872 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Hudson, Paul A1 - Pham, My A1 - Bubeck, Philip T1 - An evaluation and monetary assessment of the impact of flooding on subjective well-being across genders in Vietnam JF - Climate & development N2 - The intangible impacts of floods on welfare are not well investigated, even though they are important aspects of welfare. Moreover, flooding has gender based impacts on welfare. These differing impacts create a gender based flood risk resilience gap. We study the intangible impacts of flood risk on the subjective well-being of residents in central Vietnam. The measurement of intangible impacts through subjective well-being is a growing field within flood risk research. We find an initial drop in welfare through subjective well-being across genders when a flood is experienced. Male respondents tended to recover their welfare losses by around 80% within 5 years while female respondents were associated with a welfare recovery of around 70%. A monetization of the impacts floods have on an individual’s subjective well-being shows that for the average female respondent, between 41% to 86% of annual income would be required to compensate subjective well-being losses after 5 years of experiencing a flood. The corresponding value for males is 30% to 57% of annual income. This shows that the intangible impacts of flood risk are important (across genders) and need to be integrated into flood (or climate) risk assessments to develop more socially appropriate risk management strategies. KW - Subjective well-being KW - flood risk KW - welfare KW - gender KW - resilience KW - intangible impacts Y1 - 2019 U6 - https://doi.org/10.1080/17565529.2019.1579698 SN - 1756-5529 SN - 1756-5537 VL - 11 IS - 7 SP - 623 EP - 637 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Hudson, Paul A1 - Pham, My A1 - Bubeck, Philip T1 - An evaluation and monetary assessment of the impact of flooding on subjective well-being across genders in Vietnam T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - The intangible impacts of floods on welfare are not well investigated, even though they are important aspects of welfare. Moreover, flooding has gender based impacts on welfare. These differing impacts create a gender based flood risk resilience gap. We study the intangible impacts of flood risk on the subjective well-being of residents in central Vietnam. The measurement of intangible impacts through subjective well-being is a growing field within flood risk research. We find an initial drop in welfare through subjective well-being across genders when a flood is experienced. Male respondents tended to recover their welfare losses by around 80% within 5 years while female respondents were associated with a welfare recovery of around 70%. A monetization of the impacts floods have on an individual’s subjective well-being shows that for the average female respondent, between 41% to 86% of annual income would be required to compensate subjective well-being losses after 5 years of experiencing a flood. The corresponding value for males is 30% to 57% of annual income. This shows that the intangible impacts of flood risk are important (across genders) and need to be integrated into flood (or climate) risk assessments to develop more socially appropriate risk management strategies. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 736 KW - subjective well-being KW - flood risk KW - welfare KW - gender KW - resilience KW - intangible impacts Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433414 SN - 1866-8372 IS - 736 SP - 623 EP - 637 ER - TY - GEN A1 - Hernandez, Netzahualcoyotl A1 - Demiray, Burcu A1 - Arnrich, Bert A1 - Favela, Jesus T1 - An Exploratory Study to Detect Temporal Orientation Using Bluetooth's sensor T2 - PervasiveHealth'19: Proceedings of the 13th EAI International Conference on Pervasive Computing Technologies for Healthcare N2 - Mobile sensing technology allows us to investigate human behaviour on a daily basis. In the study, we examined temporal orientation, which refers to the capacity of thinking or talking about personal events in the past and future. We utilise the mksense platform that allows us to use the experience-sampling method. Individual's thoughts and their relationship with smartphone's Bluetooth data is analysed to understand in which contexts people are influenced by social environments, such as the people they spend the most time with. As an exploratory study, we analyse social condition influence through a collection of Bluetooth data and survey information from participant's smartphones. Preliminary results show that people are likely to focus on past events when interacting with close-related people, and focus on future planning when interacting with strangers. Similarly, people experience present temporal orientation when accompanied by known people. We believe that these findings are linked to emotions since, in its most basic state, emotion is a state of physiological arousal combined with an appropriated cognition. In this contribution, we envision a smartphone application for automatically inferring human emotions based on user's temporal orientation by using Bluetooth sensors, we briefly elaborate on the influential factor of temporal orientation episodes and conclude with a discussion and lessons learned. KW - Mobile sensing KW - Temporal orientation KW - Social environment KW - Human behaviour KW - Bluetooth Y1 - 2019 SN - 978-1-4503-6126-2 U6 - https://doi.org/10.1145/3329189.3329223 SN - 2153-1633 SP - 292 EP - 297 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Liu, Junzhong A1 - Feng, Lili A1 - Gu, Xueting A1 - Deng, Xian A1 - Qiu, Qi A1 - Li, Qun A1 - Zhang, Yingying A1 - Wang, Muyang A1 - Deng, Yiwen A1 - Wang, Ertao A1 - He, Yuke A1 - Bäurle, Isabel A1 - Li, Jianming A1 - Cao, Xiaofeng A1 - He, Zuhua T1 - An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis JF - Cell research N2 - Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation. KW - Chromatin KW - Epigenetic memory KW - Epigenetics KW - Innate immunity KW - Plant signalling Y1 - 2019 U6 - https://doi.org/10.1038/s41422-019-0145-8 SN - 1001-0602 SN - 1748-7838 VL - 29 IS - 5 SP - 379 EP - 390 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Bär, Christian A1 - Strohmaier, Alexander T1 - An index theorem for Lorentzian manifolds with compact spacelike Cauchy boundary JF - American Journal of Mathematics N2 - We show that the Dirac operator on a compact globally hyperbolic Lorentzian spacetime with spacelike Cauchy boundary is a Fredholm operator if appropriate boundary conditions are imposed. We prove that the index of this operator is given by the same expression as in the index formula of Atiyah-Patodi-Singer for Riemannian manifolds with boundary. The index is also shown to equal that of a certain operator constructed from the evolution operator and a spectral projection on the boundary. In case the metric is of product type near the boundary a Feynman parametrix is constructed. Y1 - 2019 U6 - https://doi.org/10.1353/ajm.2019.0037 SN - 0002-9327 SN - 1080-6377 VL - 141 IS - 5 SP - 1421 EP - 1455 PB - Johns Hopkins Univ. Press CY - Baltimore ER - TY - JOUR A1 - Kunft, Andreas A1 - Katsifodimos, Asterios A1 - Schelter, Sebastian A1 - Bress, Sebastian A1 - Rabl, Tilmann A1 - Markl, Volker T1 - An Intermediate Representation for Optimizing Machine Learning Pipelines JF - Proceedings of the VLDB Endowment N2 - Machine learning (ML) pipelines for model training and validation typically include preprocessing, such as data cleaning and feature engineering, prior to training an ML model. Preprocessing combines relational algebra and user-defined functions (UDFs), while model training uses iterations and linear algebra. Current systems are tailored to either of the two. As a consequence, preprocessing and ML steps are optimized in isolation. To enable holistic optimization of ML training pipelines, we present Lara, a declarative domain-specific language for collections and matrices. Lara's inter-mediate representation (IR) reflects on the complete program, i.e., UDFs, control flow, and both data types. Two views on the IR enable diverse optimizations. Monads enable operator pushdown and fusion across type and loop boundaries. Combinators provide the semantics of domain-specific operators and optimize data access and cross-validation of ML algorithms. Our experiments on preprocessing pipelines and selected ML algorithms show the effects of our proposed optimizations on dense and sparse data, which achieve speedups of up to an order of magnitude. Y1 - 2019 U6 - https://doi.org/10.14778/3342263.3342633 SN - 2150-8097 VL - 12 IS - 11 SP - 1553 EP - 1567 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Braune, Annett A1 - Gütschow, Michael A1 - Blaut, Michael T1 - An NADH-Dependent Reductase from Eubacterium ramulus Catalyzes the Stereospecific Heteroring Cleavage of Flavanones and Flavanonols JF - Applied and environmental microbiology N2 - The human intestinal anaerobe Eubacterium ramulus is known for its ability to degrade various dietary flavonoids. In the present study, we demonstrate the cleavage of the heterocyclic C-ring of flavanones and flavanonols by an oxygen-sensitive NADH-dependent reductase, previously described as enoate reductase, from E. ramulus. This flavanone- and flavanonol-cleaving reductase (Fcr) was purified following its heterologous expression in Escherichia coli and further characterized. Fcr cleaved the flavanones naringenin, eriodictyol, liquiritigenin, and homoeriodictyol. Moreover, the flavanonols taxifolin and dihydrokaempferol served as substrates. The catalyzed reactions were stereospecific for the (2R)-enantiomers of the flavanone substrates and for the (25,35)-configured flavanonols. The enantioenrichment of the nonconverted stereoisomers allowed for the determination of hitherto unknown flavanone racemization rates. Fcr formed the corresponding dihydrochalcones and hydroxydihydrochalcones in the course of an unusual reductive cleavage of cyclic ether bonds. Fcr did not convert members of other flavonoid subclasses, including flavones, flavonols, and chalcones, the latter indicating that the reaction does not involve a chalcone intermediate. This view is strongly supported by the observed enantiospecificity of Fcr. Cinnamic acids, which are typical substrates of bacterial enoate reductases, were also not reduced by Fcr. Based on the presence of binding motifs for dinucleotide cofactors and a 4Fe-4S cluster in the amino acid sequence of Fcr, a cofactor-mediated hydride transfer from NADH onto C-2 of the respective substrate is proposed. IMPORTANCE Gut bacteria play a crucial role in the metabolism of dietary flavonoids, thereby contributing to their activation or inactivation after ingestion by the human host. Thus, bacterial activities in the intestine may influence the beneficial health effects of these polyphenolic plant compounds. While an increasing number of flavonoid-converting gut bacterial species have been identified, knowledge of the responsible enzymes is still limited. Here, we characterized Fcr as a key enzyme involved in the conversion of flavonoids of several subclasses by Eubacterium ramulus, a prevalent human gut bacterium. Sequence similarity of this enzyme to hypothetical proteins from other flavonoid-degrading intestinal bacteria in databases suggests a more widespread occurrence of this enzyme. Functional characterization of gene products of human intestinal microbiota enables the assignment of metagenomic sequences to specific bacteria and, more importantly, to certain activities, which is a prerequisite for targeted modulation of gut microbial functionality. KW - Eubacterium ramulus KW - enantiospecificity KW - flavanone KW - flavanonol KW - flavonoid KW - intestinal bacteria KW - naringenin KW - reductase Y1 - 2019 U6 - https://doi.org/10.1128/AEM.01233-19 SN - 0099-2240 SN - 1098-5336 VL - 85 IS - 19 PB - American Society for Microbiology CY - Washington ER - TY - JOUR A1 - Schulze-Gabrechten, Lena T1 - An organizational approach to public governance BT - understanding and design JF - Public administration N2 - In this volume, Egeberg and Trondal put forward an ‘organizational approach to public governance’ (p. 1) that, in their view, complements existing explanations for organizational change and behaviour in governance processes (‘Understanding’) and produces relevant advice for practitioners, specifically anyone involved in reorganizing public administration (‘Design’). Following the authors’ introduction of the theoretical reasoning behind their approach (chapter 1), they present supporting findings that are based on new material (chapters 2 and 9), but mainly draw on six previously published research articles (chapters 3–8). Egeberg and Trondal conclude with possible ‘design implications’ of said findings (chapter 9). Their ‘organizational approach’ focuses on the impact of selected organizational characteristics on decision‐making in and on behalf of government organizations in policy‐making generally (‘public governance’) and administrative politics more specifically (‘meta‐governance’). The authors concentrate on three sets of ‘classical’ organizational characteristics: structure (mainly vertical and horizontal specialization), demography (personnel composition), and locus (geographical location). The conceptual part of the volume convincingly summarizes ‘formal organization matters’—arguments from the literature for each of the individual organizational factors. Their main, already well‐established argument is that the way an organization is formally set up makes some (reform) decisions more likely than others—a line of reasoning that the authors present as neglected in governance literature. In the following five empirical chapters, the authors show that aspects of horizontal and vertical specialization—mainly operationalized by Gulicks’ principles of horizontal specialization and the idea of primary versus secondary affiliation of staff—affect organizational behaviour. Readers learn that whether government levels are organized according to a territorial or non‐territorial principle impacts the power relationship between levels: non‐territorial organization at the supranational level tends to empower the centre against lower levels of government. There are two chapters on the decision‐making behaviour of commissioners and officials in the European Commission, both showing that organizational affiliation trumps demographic background factors such as nationality, even with temporary staff. Chapter 5 addresses coordination dynamics in the European multi‐level system and finds that coordination at the territorially organized national level thwarts non‐territorially organized coordination at the supranational level, resulting in the phenomenon of ‘direct’ national administration bypassing their national executives. Further, the authors show that vertical specialization—while controlling for other factors such as issue salience—has an effect on officials’ behaviour at the national level: agency officials in Norway report significantly less sensitivity towards political signals from the political executive than their colleagues in ministries. Chapter 7 discusses the relevance of geographical location for the relationship between subordinated organizations and their political executive. The authors find that the site of Norwegian agencies does not significantly affect their autonomy, influence, or inter‐institutional coordination with the superior ministry. The last empirical chapter focuses on the effect of formal organization on meta‐governance, that is, administrative politics. Based on a qualitative case study of a reorganization process in Norway in 2003 involving the synchronized relocation of several agencies after many failed attempts, the authors conclude that administrative reforms can be politically steered and controlled through the organization of the reform process. They argue that amongst other factors the strategic exclusion of opposing actors from the reform process as well as the deliberate increase in situations demanding quick decisions (‘action rationality’, p. 119) by political leaders helps explain the reform's unexpected success. The last chapter is dedicated to the synthesis of the results and to design implications. Supported by new data from a 2016 survey among Norwegian public officials, the authors conclude that organizational position is the most important influencer of decision‐making behaviour, with educational background and previous job experience also playing a large role (p. 135). Consequently, their suggestions for practitioners involved in meta‐governance processes concentrate on aspects of the deliberate crafting of organizational specialization to shape organizational positions, and spend less time discussing location and employee demographics. The authors illustrate and contextualize their recommendations with the help of three empirical examples: organizing good governance by balancing political control and independence in the case of agencification, organizing for coping with boundary‐spanning challenges such as climate change through inter‐organizational structural arrangements, and designing permanent organizational structures for innovative reforms in the public sector (pp. 137 ff.). This volume is an excellent compilation of theoretically informed applications of the all too often undefined ‘organization matters’ argument. It juxtaposes—particularly in the theory chapter and in the last chapter on design implications—organizational arguments against other explanations of organizational change like historical institutionalism or the garbage can model of decision‐making. However, two major aspects of the book's approach are less convincing. First, supplementary explanations such as the garbage can model that are discussed in the reflections on meta‐governance are neither argumentatively nor empirically applied to public governance; why should, for example, the ‘solutions in search of a problem’ idea only be applicable to decisions on reform policy, but not to decisions in all other policy areas? Similarly, it would have been nice to read more on the authors’ idea on the interaction between organizational factors and between them and other explanations in the empirical cases on public governance—this would have allowed the reader to get a better idea about how much formal organization matters. The view on bureaucrats’ demographic background is slightly confusing: it is presented as a competing approach (p. 7), but also as one of the main organizational factors (p. 12). Second, as the authors themselves state, the concept of governance is about ‘steering through collective action’ (p. 3) and focuses on interactive processes, and explicitly includes non‐governmental actors in the policy‐making equation. Against this background it seems unfortunate that most of the work presented in the book takes an exclusively governmental perspective and the justification for it remains rather superficial. It would be preferable and even necessary to see the organizational arguments—at least theoretically or through discussing appropriate literature—applied to interactive governance processes involving other actors and/or to non‐bureaucratic organizations. Regarding its methodology, the specifics of the proposed approach deserve to be addressed more systematically and critically in the book. Except for chapters 2, 3 and 5 (literature‐based studies) as well as chapter 8 (single case study), the empirical studies follow a quantitative logic and are informed by data on self‐reported behaviour through large‐N panel surveys with public officials. In terms of analysis, descriptive statistics or basic inferential statistics (linear regression) are employed. Certainly, the authors are aware of the limitations of their data sources, such as the results being possibly affected by social desirability, and they discuss and justify them in the chapters individually (e.g., on pp. 47, 89). Still, their approach could be strengthened with a more cautious account on the extent to which their choice of data and methods is able to uncover the ‘causal impact of organizational factors in public governance processes’ (p. 131, emphasis added) and with some suggestions for widening their methodological toolbox in the future. On this note, the survey method presented as new on p. 135 is not a particularly convincing choice. The authors do not lay out a research agenda; a surprising omission. This is, however, somewhat made up for by the concluding chapter's stimulating discussion of the possible real‐world implications of their findings and perspective, skilfully using organization theory as a ‘craft’ (p. 29). Y1 - 2019 U6 - https://doi.org/10.1111/padm.12590 SN - 0033-3298 SN - 1467-9299 VL - 97 IS - 2 SP - 483 EP - 485 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Saltikoff, Elena A1 - Friedrich, Katja A1 - Soderholm, Joshua A1 - Lengfeld, Katharina A1 - Nelson, Brian A1 - Becker, Andreas A1 - Hollmann, Rainer A1 - Urban, Bernard A1 - Heistermann, Maik A1 - Tassone, Caterina T1 - An Overview of Using Weather Radar for Climatological Studies: Successes, Challenges, and Potential JF - Bulletin of the American Meteorological Society N2 - Weather radars have been widely used to detect and quantify precipitation and nowcast severe weather for more than 50 years. Operational weather radars generate huge three-dimensional datasets that can accumulate to terabytes per day. So it is essential to review what can be done with existing vast amounts of data, and how we should manage the present datasets for the future climatologists. All weather radars provide the reflectivity factor, and this is the main parameter to be archived. Saving reflectivity as volumetric data in the original spherical coordinates allows for studies of the three-dimensional structure of precipitation, which can be applied to understand a number of processes, for example, analyzing hail or thunderstorm modes. Doppler velocity and polarimetric moments also have numerous applications for climate studies, for example, quality improvement of reflectivity and rain rate retrievals, and for interrogating microphysical and dynamical processes. However, observational data alone are not useful if they are not accompanied by sufficient metadata. Since the lifetime of a radar ranges between 10 and 20 years, instruments are typically replaced or upgraded during climatologically relevant time periods. As a result, present metadata often do not apply to past data. This paper outlines the work of the Radar Task Team set by the Atmospheric Observation Panel for Climate (AOPC) and summarizes results from a recent survey on the existence and availability of long time series. We also provide recommendations for archiving current and future data and examples of climatological studies in which radar data have already been used. Y1 - 2019 U6 - https://doi.org/10.1175/BAMS-D-18-0166.1 SN - 0003-0007 SN - 1520-0477 VL - 100 IS - 9 SP - 1739 EP - 1751 PB - American Meteorological Soc. CY - Boston ER - TY - JOUR A1 - Helber, Bernd A1 - Dias, Bruno A1 - Bariselli, Federico A1 - Zavalan, Luiza F. A1 - Pittarello, Lidia A1 - Goderis, Steven A1 - Soens, Bastien A1 - McKibbin, Seann J. A1 - Claeys, Philippe A1 - Magin, Thierry E. T1 - Analysis of meteoroid ablation based on plasma wind-tunnel experiments, surface characterization, and numerical simulations JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - Meteoroids largely disintegrate during their entry into the atmosphere, contributing significantly to the input of cosmic material to Earth. Yet, their atmospheric entry is not well understood. Experimental studies on meteoroid material degradation in high-enthalpy facilities are scarce and when the material is recovered after testing, it rarely provides sufficient quantitative data for the validation of simulation tools. In this work, we investigate the thermochemical degradation mechanism of a meteorite in a high-enthalpy ground facility able to reproduce atmospheric entry conditions. A testing methodology involving measurement techniques previously used for the characterization of thermal protection systems for spacecraft is adapted for the investigation of ablation of alkali basalt (employed here as meteorite analog) and ordinary chondrite samples. Both materials are exposed to a cold-wall stagnation point heat flux of 1.2 MW m(-2). Numerous local pockets that formed on the surface of the samples by the emergence of gas bubbles reveal the frothing phenomenon characteristic of material degradation. Time-resolved optical emission spectroscopy data of ablated species allow us to identify the main radiating atoms and ions of potassium, calcium, magnesium, and iron. Surface temperature measurements provide maximum values of 2280 K for the basalt and 2360 K for the chondrite samples. We also develop a material response model by solving the heat conduction equation and accounting for evaporation and oxidation reaction processes in a 1D Cartesian domain. The simulation results are in good agreement with the data collected during the experiments, highlighting the importance of iron oxidation to the material degradation. KW - meteorites, meteors, meteoroids KW - plasmas KW - techniques: spectroscopic Y1 - 2019 U6 - https://doi.org/10.3847/1538-4357/ab16f0 SN - 0004-637X SN - 1538-4357 VL - 876 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Bentz, Stephan A1 - Martinez-Garzon, Patricia A1 - Kwiatek, Grzegorz A1 - Dresen, Georg A1 - Bohnhoff, Marco T1 - Analysis of Microseismicity Framing M-L > 2.5 Earthquakes at The Geysers Geothermal Field, California JF - Journal of geophysical research : Solid earth N2 - Preparatory mechanisms accompanying or leading to nucleation of larger earthquakes have been observed at both laboratory and field scales, but conditions favoring the occurrence of observable preparatory processes are still largely unknown. In particular, it remains a matter of debate why some earthquakes occur spontaneously without noticeable precursors as opposed to events that are preceded by an extended failure process. In this study, we have generated new high-resolution seismicity catalogs framing the occurrence of 20 M-L > 2.5 earthquakes at The Geysers geothermal field in California. To this end, a seismicity catalog of the 11 days framing each large event was created. We selected 20 sequences sampling different hypocentral depths and hydraulic conditions within the field. Seismic activity and magnitude frequency distributions displayed by the different earthquake sequences are correlated with their location within the reservoir. Sequences located in the northwestern part of the reservoir show overall increased seismic activity and low b values, while the southeastern part is dominated by decreased seismic activity and higher b values. Periods of high injection coincide with high b values and vice versa. These observations potentially reflect varying differential and mean stresses and damage of the reservoir rocks across the field. About 50% of analyzed sequences exhibit no change in seismicity rate in response to the large main event. However, we find complex waveforms at the onset of the main earthquake, suggesting that small ruptures spontaneously grow into or trigger larger events. KW - induced seismicity KW - earthquake nucleation KW - The Geysers KW - earthquake sequences Y1 - 2019 U6 - https://doi.org/10.1029/2019JB017716 SN - 2169-9313 SN - 2169-9356 VL - 124 IS - 8 SP - 8823 EP - 8843 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Rinaldi, G. A1 - Formisano, M. A1 - Kappel, David A1 - Capaccioni, F. A1 - Bockelee-Morvan, D. A1 - Cheng, Y-C A1 - Vincent, J-B A1 - Deshapriya, P. A1 - Arnold, G. A1 - Capria, M. T. A1 - Ciarniello, M. A1 - De Sanctis, M. C. A1 - Doose, L. A1 - Erard, S. A1 - Federico, C. A1 - Filacchione, G. A1 - Fink, U. A1 - Leyrat, C. A1 - Longobardo, A. A1 - Magni, G. A1 - Mighorini, A. A1 - Mottola, S. A1 - Naletto, G. A1 - Raponi, A. A1 - Taylor, F. A1 - Tosi, F. A1 - Tozzi, G. P. A1 - Salatti, M. T1 - Analysis of night-side dust activity on comet 67P observed by VIRTIS-M BT - a new method to constrain the thermal inertia on the surface JF - Astronomy and astrophysics : an international weekly journal N2 - On 2015 July 18, near perihelion at a heliocentric distance of 1.28 au, the Visible InfraRed Thermal Imaging Spectrometer (VIRTIS-M) on board the Rosetta spacecraft had the opportunity of observing dust activity in the inner coma with a view of the night side (shadowed side) of comet 67P/Churyumov-Gerasimenko. At the time of the measurements we present here, we observe a dust plume that originates on the far side of the nucleus. We are able to identify the approximate location of its source at the boundary between the Hapi and Anuket regions, and we find that it has been in darkness for some hours before the observation. Assuming that this time span is equal to the conductive time scale, we obtain a thermal inertia in the range 25-36 W K-1 m(-2) s(-1/2). These thermal inertia values can be used to verify with a 3D finite-element method (REM) numerical code whether the surface and subsurface temperatures agree with the values found in the literature. We explored three different configurations: (1) a layer of water ice mixed with dust beneath a dust mantle of 5 mm with thermal inertia of 36 J m(-2) K-1 S-0.5 ; (2) the same structure, but with thermal inertia of 100 J m(-2) K-1 S-0.5; (3) an ice-dust mixture that is directly exposed. Of these three configurations, the first seems to be the most reasonable, both for the low thermal inertia and for the agreement with the surface and subsurface temperatures that have been found for the comet 67P/Churyumov-Gerasimenko. The spectral properties of the plume show that the visible dust color ranged from 16 +/- 4.8%/100 nm to 13 +/- 2.6%/100 nm, indicating that this plume has no detectable color gradient. The morphology of the plume can be classified as a narrow jet that has an estimated total ejected mass of between 6 and 19 tons when we assume size distribution indices between -2.5 and -3. KW - comets: general KW - comets: individual: 67P/Churyumov-Gerasimenko KW - infrared: planetary systems Y1 - 2019 U6 - https://doi.org/10.1051/0004-6361/201834907 SN - 1432-0746 VL - 630 PB - EDP Sciences CY - Les Ulis ER - TY - THES A1 - Grafe, Marianne Erika T1 - Analysis of supramolecular assemblies of NE81, the first lamin protein in a non-metazoan organism T1 - Analyse von supramolekularen Komplexen von NE81, dem ersten Lamin in einem nicht-metazoischen Organismus N2 - Lamine sind Proteine an der inneren Kernhülle und bilden zusammen mit verbundenen Proteinen die nukleäre Lamina. Dieses Netzwerk sorgt für die Stabilität des Zellkerns und unterstützt die Organisation des Zell-Zytoskeletts. Zusätzlich sind Lamine und ihre verbundenen Proteine in viele Prozesse wie Genregulation und Zelldifferenzierung involviert. Bis 2012 war der Stand der Forschung, dass nur bei mehrzelligen Organismen eine nukleäre Lamina zu finden ist. NE81 ist das erste lamin-ähnliche Protein, das in einem nicht-mehrzelligen Organismus (Dictyostelium discoideum) entdeckt wurde. Es hat viele Eigenschaften und Strukturmerkmale mit Laminen gemeinsam. Dazu zählt der dreiteilige Aufbau des Proteins, eine Phosphorylierungsstelle für ein Zellzyklus-abhängiges Enzym, ein Kernlokalisationssignal, wodurch das Protein in den Kern transportiert wird, sowie eine C-terminale Sequenz zur Verankerung des Proteins in der Kernhülle. In dieser Arbeit wurden verschiedene Methoden zur vereinfachten Untersuchung von Laminstrukturen getestet, um zu zeigen, dass sich NE81 wie bereits bekannte Lamin-Proteine verhält und supramolekulare Netzwerke aus Laminfilamenten bildet. Zur Analyse der Struktur supramolekularer Anordnungen wurde das Protein durch Entfernen des Kernlokalisationssignals auf der äußeren Kernhülle von Dictyostelium gebildet. Die anschließende Untersuchung der Oberfläche der Kerne mit einem Rasterelektronenmikroskop zeigte, dass NE81 Strukturen in der Größe von Laminen bildet, allerdings nicht in regelmäßigen filamentösen Anordnungen. Um die Entstehung der Laminfilamente zu untersuchen, wurde lösliches NE81 aus Dictyostelium aufgereinigt und mit verschiedenen mikroskopischen Methoden untersucht. Dabei wurde festgestellt, dass NE81 unter Niedrigsalz-Bedingungen dünne, fadenförmige Strukturen und Netzwerke ausbildet, die denen von Säugetier-Laminen sehr ähnlich sind. Die Mutation der Phosphorylierungsstelle von NE81 zu einer imitierenden dauerhaften Phosphorylierung von NE81 in der Zelle, zeigte zunächst ein gelöstes Protein, das überraschenderweise unter Blaulichtbestrahlung der Zelle wieder lamin-ähnliche Anordnungen formte. Die Ergebnisse dieser Arbeit zeigen, dass NE81 echte Laminstrukturen ausbilden kann und hebt Dictyostelium als Nicht-Säugetier-Modellorganismus mit einer gut charakterisierten Kernhülle, mit allen relevanten, aus tierischen Zellen bekannten Proteinen, hervor. N2 - Nuclear lamins are nucleus-specific intermediate filaments forming a network located at the inner nuclear membrane of the nuclear envelope. They form the nuclear lamina together with proteins of the inner nuclear membrane regulating nuclear shape and gene expression, among others. The amoebozoan Dictyostelium NE81 protein is a suitable candidate for an evolutionary conserved lamin protein in this non-metazoan organism. It shares the domain organization of metazoan lamins and is fulfilling major lamin functions in Dictyostelium. Moreover, field-emission scanning electron microscopy (feSEM) images of NE81 expressed on Xenopus oocytes nuclei revealed filamentous structures with an overall appearance highly reminiscent to that of metazoan Xenopus lamin B2. For the classification as a lamin-like or a bona fide lamin protein, a better understanding of the supramolecular NE81 structure was necessary. Yet, NE81 carrying a large N-terminal GFP-tag turned out as unsuitable source for protein isolation and characterization; GFP-NE81 expressed in Dictyostelium NE81 knock-out cells exhibited an abnormal distribution, which is an indicator for an inaccurate assembly of GFP-tagged NE81. Hence, a shorter 8×HisMyc construct was the tag of choice to investi-gate formation and structure of NE81 assemblies. One strategy was the structural analysis of NE81 in situ at the outer nuclear membrane in Dictyostelium cells; NE81 without a func-tional nuclear localization signal (NLS) forms assemblies at the outer face of the nucleus. Ultrastructural feSEM pictures of NE81ΔNLS nuclei showed a few filaments of the expected size but no repetitive filamentous structures. The former strategy should also be established for metazoan lamins in order to facilitate their structural analysis. However, heterologously expressed Xenopus and C. elegans lamins showed no uniform localization at the outer nucle-ar envelope of Dictyostelium and hence, no further ultrastructural analysis was undertaken. For in vitro assembly experiments a Dictyostelium mutant was generated, expressing NE81 without the NLS and the membrane-anchoring isoprenylation site (HisMyc-NE81ΔNLSΔCLIM). The cytosolic NE81 clusters were soluble at high ionic strength and were purified from Dictyostelium extracts using Ni-NTA Agarose. Widefield immunofluorescence microscopy, super-resolution light microscopy and electron microscopy images of purified NE81 showed its capability to form filamentous structures at low ionic strength, as described previously for metazoan lamins. Introduction of a phosphomimetic point mutation (S122E) into the CDK1-consensus sequence of NE81 led to disassembled NE81 protein in vivo, which could be reversibly stimulated to form supramolecular assemblies by blue light exposure. The results of this work reveal that NE81 has to be considered a bona fide lamin, since it is able to form filamentous assemblies. Furthermore, they highlight Dictyostelium as a non-mammalian model organism with a well-characterized nuclear envelope containing all rele-vant protein components known in animal cells. KW - lamin KW - NE81 KW - Dictyostelium KW - nuclear envelope KW - nuclear lamina KW - expansion microscopy KW - Lamin KW - NE81 KW - Dictyostelium KW - Kernhülle KW - nukleäre Lamina KW - Expansions-Mikroskopie Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441802 ER - TY - JOUR A1 - Neukranz, Yannika A1 - Kotter, Annika A1 - Beilschmidt, Lena A1 - Marelja, Zvonimir A1 - Helm, Mark A1 - Graf, Ralph A1 - Leimkühler, Silke T1 - Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome JF - Biochemistry N2 - The deficiency of the molybdenum cofactor (Moco) is an autosomal recessive disease, which leads to the loss of activity of all molybdoenzymes in humans with sulfite oxidase being the essential protein. Moco deficiency generally results in death in early childhood. Moco is a sulfur-containing cofactor synthesized in the cytosol with the sulfur being provided by a sulfur relay system composed of the L-cysteine desulfurase NFS1, MOCS3, and MOCS2A. Human MOCS3 is a dual-function protein that was shown to play an important role in Moco biosynthesis and in the mcm(5)s(2) U thio modifications of nucleosides in cytosolic tRNAs for Lys, Gln, and Glu. In this study, we constructed a homozygous MOCS3 knockout in HEK293T cells using the CRISPR/Cas9 system. The effects caused by the absence of MOCS3 were analyzed in detail. We show that sulfite oxidase activity was almost completely abolished, on the basis of the absence of Moco in these cells. In addition, mcm(5)s(2)U thio-modified tRNAs were not detectable. Because the L-cysteine desulfurase NFS1 was shown to act as a sulfur donor for MOCS3 in the cytosol, we additionally investigated the impact of a MOCS3 knockout on the cellular localization of NFS1. By different methods, we identified a MOCS3-independent novel localization of NFS1 at the centrosome. Y1 - 2019 U6 - https://doi.org/10.1021/acs.biochem.8b01160 SN - 0006-2960 VL - 58 IS - 13 SP - 1786 EP - 1798 PB - American Chemical Society CY - Washington ER - TY - THES A1 - Petrovic, Nevena T1 - Analysis of the role of Forgetter2 in thermotolerance responses in Arabidopsis thaliana Y1 - 2019 ER - TY - THES A1 - Nikkhoo, Mehdi T1 - Analytical and numerical elastic dislocation models of volcano deformation processes T1 - Analytische und numerische Dislokationsmodelle von Verformungsprozessen an Vulkanen N2 - The advances in modern geodetic techniques such as the global navigation satellite system (GNSS) and synthetic aperture radar (SAR) provide surface deformation measurements with an unprecedented accuracy and temporal and spatial resolutions even at most remote volcanoes on Earth. Modelling of the high-quality geodetic data is crucial for understanding the underlying physics of volcano deformation processes. Among various approaches, mathematical models are the most effective for establishing a quantitative link between the surface displacements and the shape and strength of deformation sources. Advancing the geodetic data analyses and hence, the knowledge on the Earth’s interior processes, demands sophisticated and efficient deformation modelling approaches. Yet the majority of these models rely on simplistic assumptions for deformation source geometries and ignore complexities such as the Earth’s surface topography and interactions between multiple sources. This thesis addresses this problem in the context of analytical and numerical volcano deformation modelling. In the first part, new analytical solutions for triangular dislocations (TDs) in uniform infinite and semi-infinite elastic media have been developed. Through a comprehensive investigation, the locations and causes of artefact singularities and numerical instabilities associated with TDs have been determined and these long-standing drawbacks have been addressed thoroughly. This approach has then been extended to rectangular dislocations (RDs) with full rotational degrees of freedom. Using this solution in a configuration of three orthogonal RDs a compound dislocation model (CDM) has been developed. The CDM can represent generalized volumetric and planar deformation sources efficiently. Thus, the CDM is relevant for rapid inversions in early warning systems and can also be used for detailed deformation analyses. In order to account for complex source geometries and realistic topography in the deformation models, in this thesis the boundary element method (BEM) has been applied to the new solutions for TDs. In this scheme, complex surfaces are simulated as a continuous mesh of TDs that may possess any displacement or stress boundary conditions in the BEM calculations. In the second part of this thesis, the developed modelling techniques have been applied to five different real-world deformation scenarios. As the first and second case studies the deformation sources associated with the 2015 Calbuco eruption and 2013–2016 Copahue inflation period have been constrained by using the CDM. The highly anisotropic source geometries in these two cases highlight the importance of using generalized deformation models such as the CDM, for geodetic data inversions. The other three case studies in this thesis involve high-resolution dislocation models and BEM calculations. As the third case, the 2013 pre-explosive inflation of Volcán de Colima has been simulated by using two ellipsoidal cavities, which locate zones of pressurization in the volcano’s lava dome. The fourth case study, which serves as an example for volcanotectonics interactions, the 3-D kinematics of an active ring-fault at Tendürek volcano has been investigated through modelling displacement time series over the 2003–2010 time period. As the fifth example, the deformation sources associated with North Korea’s underground nuclear test in September 2017 have been constrained. These examples demonstrate the advancement and increasing level of complexity and the general applicability of the developed dislocation modelling techniques. This thesis establishes a unified framework for rapid and high-resolution dislocation modelling, which in addition to volcano deformations can also be applied to tectonic and humanmade deformations. N2 - Fortschritte in modernen geodätischen Techniken wie dem globalen Navigationssatellitensystem (GNSS) und dem Synthetic Apertur Radar (SAR), liefern Messungen der Oberflächenverformung mit einer beispiellosen Genauigkeit sowie zeitlichen und räumlichen Auflösungen, selbst an abgelegensten Vulkanen. Die Modellierung von hochqualitativen geodätischen Daten ist entscheidend für das Verständnis der zugrundeliegenden Physik der Verformungsprozesse an diesen Vulkanen. Um eine quantitative Verbindung zwischen den Oberflächenverschiebungen und der Form und Stärke von Verformungsquellen herzustellen, sind mathematische Modelle am effektivsten. Die Fortschnitte in geodätischen Datenanalysen und damit das Wissen über die Prozesse im Inneren der Erde erfordern ausgefeilte und effiziente Ansätze der Verformungsmodellierung. Die meisten dieser Modelle beruhen jedoch auf vereinfachten Annahmen der Geometrien der Verformungsquellen und ignorieren Komplexitäten wie die Erdoberflächentopographie und Wechselwirkungen zwischen mehreren Quellen. Diese Doktorarbeit befasst sich mit diesem Problem im Kontext der analytischen und numerischen Vulkanverformungsmodellierung. Im ersten Schritt wurden neue analytische Lösungen für dreieckige Dislokationen (triangular dislocation-TD) im gleichförmigen elastischen Voll- und Halbraum entwickelt. Durch eine umfassende Untersuchung wurden die Orte und Ursachen von TDs verbundenen Artefaktsingularitäten und numerischen Instabilitäten identifiziert und diese Problematik gelöst. Dieser Ansatz wurde dann auf rechteckige Dislokationen (rectangular dislocation-RD) mit vollen Rotationsfreiheitsgraden erweitert. Unter Verwendung dieser Lösung in einer Konfiguration von drei orthogonalen RDs wurde ein “Zusammengesetztes Dislokationsmodel” (compound dislocation model-CDM) entwickelt. Das CDM kann verallgemeinerte volumetrische und planare Verformungsquellen effizient darstellen. Somit ist das CDM für schnelle Inversionen in Frühwarnungssystemen relevant und kann auch für detaillierte Verformungsanalysen verwendet werden. Um komplexe Quellengeometrien und eine realistische Topographie in den Verformungsmodellen dieser Untersuchung zu berücksichtigen, wurde die Randelementmethode (REM) auf die neuen Lösungen für TDs angewendet. In diesem Schema werden komplexe Oberflächen als ein kontinuierliches Netz von DVs simuliert, die in den REM-Berechnungen beliebige Verschiebungs- oder Spannungsgrenzbedingungen aufweisen können. Als Beispiele wurden die entwickelten Modellierungstechniken auf fünf verschiedene reale Verformungsszenarien angewendet. Das erste und zweite Beispiel, die Calbuco-Eruption 2015 und die 2013–2016 Copahue-Aufwölbungsperiode, wurden durch die Verwendung des CDM näher beschrieben. Die hoch anisotropen Quellengeometrien in diesen beiden Fällen unterstreichen die Bedeutung der Verwendung verallgemeinerter Verformungsmodelle wie dem CDM für geodätische Dateninversionen. Weitere Fallstudien dieser Doktorarbeit umfassen hochauflösende Versetzungsmodelle und REM-Berechnungen. Die Aufwölbung 2013 am Volcán de Colima wurde simuliert, indem zwei ellipsoidale Quellen verwendet wurden, die Druckzonen im Lavadom des Vulkans lokalisieren. Danach, als Beispiel für Vulkantektonik-Interaktionen, wurde die 3-D-Kinematik einer aktiven Ringstörung am Tendürek-Vulkan durch Modellierung von InSAR-Zeitreihen über die Zeitperiode 2003–2010 simuliert. Als letztes Beispiel wurden die Verformungsquellen, die im Zusammenhang mit Nordkoreas unterirdischem Atomtest im September 2017 stehen, simuliert und der Einsatz der verwendeten Methoden auch in nicht vulkanischen Terrain gezeigt. Diese Beispiele zeigen den Fortschritt und das zunehmende Niveau der Komplexität und die allgemeine Anwendbarkeit der entwickelten Dislokationsmodellierungstechniken. Diese Doktorarbeit unterstreicht die Anwendung von neuer schneller und hochauflösender Dislokationsmodellierung, die neben Vulkanverformungen auch auf tektonische und vom Menschen verursachte Verformungen angewendet werden kann. KW - Volcano deformation modelling KW - Triangular dislocations (TDs) KW - Compound dislocation models (CDMs) KW - Inverse modelling KW - crustal deformations KW - Vulkanverformungsmodellierung KW - dreieckige Dislokationen (TDs) KW - Zusammengesetztes Dislokationsmodel (CDM) KW - inverse Modellirung KW - Krustenverformungen Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-429720 ER - TY - JOUR A1 - Wang, Dedong A1 - Shprits, Yuri Y. A1 - Zhelayskaya, Irina S. A1 - Agapitov, Oleksiy A1 - Drozdov, Alexander A1 - Aseev, Nikita T1 - Analytical chorus wave model derived from van Allen Probe Observations JF - Journal of geophysical research : Space physics N2 - Chorus waves play an important role in the dynamic evolution of energetic electrons in the Earth's radiation belts and ring current. Using more than 5 years of Van Allen Probe data, we developed a new analytical model for upper‐band chorus (UBC; 0.5fce < f < fce) and lower‐band chorus (LBC; 0.05fce < f < 0.5fce) waves, where fce is the equatorial electron gyrofrequency. By applying polynomial fits to chorus wave root mean square amplitudes, we developed regression models for LBC and UBC as a function of geomagnetic activity (Kp), L, magnetic latitude (λ), and magnetic local time (MLT). Dependence on Kp is separated from the dependence on λ, L, and MLT as Kp‐scaling law to simplify the calculation of diffusion coefficients and inclusion into particle tracing codes. Frequency models for UBC and LBC are also developed, which depends on MLT and magnetic latitude. This empirical model is valid in all MLTs, magnetic latitude up to 20°, Kp ≤ 6, L‐shell range from 3.5 to 6 for LBC and from 4 to 6 for UBC. The dependence of root mean square amplitudes on L are different for different bands, which implies different energy sources for different wave bands. This analytical chorus wave model is convenient for inclusion in quasi‐linear diffusion calculations of electron scattering rates and particle simulations in the inner magnetosphere, especially for the newly developed four‐dimensional codes, which require significantly improved wave parameterizations. KW - chorus waves KW - radiation belt electrons KW - ring current electrons KW - analytical model KW - wave-particle interactions KW - diffusion coefficients Y1 - 2019 U6 - https://doi.org/10.1029/2018JA026183 SN - 2169-9380 SN - 2169-9402 VL - 124 IS - 2 SP - 1063 EP - 1084 PB - American Geophysical Union CY - Washington ER - TY - THES A1 - Sterzel, Till T1 - Analyzing global typologies of socio-ecological vulnerability BT - the cases of human security in drylands, and rapid coastal urbanization N2 - On a planetary scale human populations need to adapt to both socio-economic and environmental problems amidst rapid global change. This holds true for coupled human-environment (socio-ecological) systems in rural and urban settings alike. Two examples are drylands and urban coasts. Such socio-ecological systems have a global distribution. Therefore, advancing the knowledge base for identifying socio-ecological adaptation needs with local vulnerability assessments alone is infeasible: The systems cover vast areas, while funding, time, and human resources for local assessments are limited. They are lacking in low an middle-income countries (LICs and MICs) in particular. But places in a specific socio-ecological system are not only unique and complex – they also exhibit similarities. A global patchwork of local rural drylands vulnerability assessments of human populations to socio-ecological and environmental problems has already been reduced to a limited number of problem structures, which typically cause vulnerability. However, the question arises whether this is also possible in urban socio-ecological systems. The question also arises whether these typologies provide added value in research beyond global change. Finally, the methodology employed for drylands needs refining and standardizing to increase its uptake in the scientific community. In this dissertation, I set out to fill these three gaps in research. The geographical focus in my dissertation is on LICs and MICs, which generally have lower capacities to adapt, and greater adaptation needs, regarding rapid global change. Using a spatially explicit indicator-based methodology, I combine geospatial and clustering methods to identify typical configurations of key factors in case studies causing vulnerability to human populations in two specific socio-ecological systems. Then I use statistical and analytical methods to interpret and appraise both the typical configurations and the global typologies they constitute. First, I improve the indicator-based methodology and then reanalyze typical global problem structures of socio-ecological drylands vulnerability with seven indicator datasets. The reanalysis confirms the key tenets and produces a more realistic and nuanced typology of eight spatially explicit problem structures, or vulnerability profiles: Two new profiles with typically high natural resource endowment emerge, in which overpopulation has led to medium or high soil erosion. Second, I determine whether the new drylands typology and its socio-ecological vulnerability concept advance a thematically linked scientific debate in human security studies: what drives violent conflict in drylands? The typology is a much better predictor for conflict distribution and incidence in drylands than regression models typically used in peace research. Third, I analyze global problem structures typically causing vulnerability in an urban socio-ecological system - the rapidly urbanizing coastal fringe (RUCF) – with eleven indicator datasets. The RUCF also shows a robust typology, and its seven profiles show huge asymmetries in vulnerability and adaptive capacity. The fastest population increase, lowest income, most ineffective governments, most prevalent poverty, and lowest adaptive capacity are all typically stacked in two profiles in LICs. This shows that beyond local case studies tropical cyclones and/or coastal flooding are neither stalling rapid population growth, nor urban expansion, in the RUCF. I propose entry points for scaling up successful vulnerability reduction strategies in coastal cities within the same vulnerability profile. This dissertation shows that patchworks of local vulnerability assessments can be generalized to structure global socio-ecological vulnerabilities in both rural and urban socio-ecological systems according to typical problems. In terms of climate-related extreme events in the RUCF, conflicting problem structures and means to deal with them are threatening to widen the development gap between LICs and high-income countries unless successful vulnerability reduction measures are comprehensively scaled up. The explanatory power for human security in drylands warrants further applications of the methodology beyond global environmental change research in the future. Thus, analyzing spatially explicit global typologies of socio-ecological vulnerability is a useful complement to local assessments: The typologies provide entry points for where to consider which generic measures to reduce typical problem structures – including the countless places without local assessments. This can save limited time and financial resources for adaptation under rapid global change. N2 - Menschliche Gesellschaften müssen sich weltweit an sozioökonomische und ökologische Probleme unter rapidem globalen Wandel anpassen. Dies gilt für gekoppelte Mensch-Umwelt-Systeme (sozio-ökologische Systeme) in ländlichen und in städtischen Gebieten. Beispiele sind Trockengebiete oder urban geprägte Küsten. Solche sozio-ökologischen Systeme haben eine globale Ausdehnung. Daher ist es nicht praktikabel, die Wissensbasis zur Ermittlung des sozio-ökologischen Anpassungsbedarfs allein mit lokalen Vulnerabilitätsanalysen voranzutreiben: Die Systeme decken große Gebiete ab, während finanzielle Mittel, Zeit und Personal für lokale Analysen begrenzt sind. In Ländern mit niedrigem und mittlerem Einkommen (LICs und MICs) mangelt es daran besonders. Aber Orte in einem konkreten sozioökologischen System sind nicht nur einzigartig und komplex – sie weisen auch Gemeinsamkeiten auf. Ein globaler Flickenteppich lokaler Vulnerabilitätsanalysen von Gesellschaften gegenüber sozioökonomischen und ökologischen Problemen in Trockengebieten wurde bereits auf eine begrenzte Anzahl von Problemstrukturen reduziert, die typischerweise Verwundbarkeiten verursachen. Es stellt sich jedoch die Frage, ob dies auch in urbanen sozioökologischen Systemen möglich ist. Es stellt sich auch die Frage, ob diese Typologien über die Forschung zum globalen Wandel hinaus einen Mehrwert bieten. Schließlich muss die für Trockengebiete angewandte Methodik verfeinert und standardisiert werden, um ihre Aufnahme in der Wissenschaft zu erhöhen. In dieser Dissertation habe ich versucht, diese drei Forschungslücken zu schließen. Der geografische Schwerpunkt meiner Dissertation liegt auf LICs und MICs, die im Allgemeinen über geringere Anpassungskapazitäten und einen größeren Anpassungsbedarf gegenüber schnellen globalen Wandels verfügen. Unter Verwendung einer räumlich expliziten, indikatorgestützten Methodik kombiniere ich raumbezogene und Clustering-Methoden, um typische Konfigurationen von Schlüsselfaktoren in Fallstudien zu identifizieren, die Verwundbarkeiten für Gesellschaften in zwei spezifischen sozio-ökologischen Systemen verursachen. Dann benutze ich statistische und analytische Methoden, um sowohl die typischen Konfigurationen als auch die globalen Typologien zu interpretieren und zu bewerten. Im ersten Teil verbessere ich die indikatorbasierte Methodik und reanalysiere dann typische globale Problemstrukturen sozioökologischer Verwundbarkeit in ländlichen Trockengebieten mit sieben Indikatordatensätzen. Die Reanalyse bestätigt die Kernaussagen und führt zu einer realistischeren und differenzierteren Typologie von acht räumlich expliziten Problemstrukturen bzw. Vulnerabilitätsprofilen: Zwei neue Profile mit typischer hoher natürlicher Ressourcenausstattung treten auf, in denen Überbevölkerung zu mittlerer bis hoher Bodenerosion geführt hat. Im zweiten Teil stelle ich fest, ob die neue Trockengebietstypologie und ihr sozioökologisches Vulnerabilitätskonzept eine thematisch verknüpfte wissenschaftliche Debatte über menschliche Sicherheit vorantreiben können: Was treibt gewalttätige Konflikte in Trockengebieten an? Die Typologie ist ein deutlich besserer Prädiktor für die Verteilung und Inzidenz von Konflikten in Trockengebieten als Regressionsmodelle, die typischerweise in der Friedensforschung verwendet werden. Im dritten Teil analysiere ich mit elf Indikatordatensätzen globale Problemstrukturen, die in einem urbanen sozioökologischen System - der rapide urbanisierenden Küstenzone (RUCF) – typischerweise Verwundbarkeiten verursachen. Die RUCF weist ebenfalls eine robuste Typologie auf und ihre sieben Profile zeigen große Asymmetrien in Bezug auf Vulnerabilität und Anpassungskapazität. Der schnellste Bevölkerungszuwachs, das niedrigste Einkommen, die ineffektivsten Regierungen, die am weitesten verbreitete Armut und die geringste Anpassungskapazität sind typischerweise in zwei Profilen in LICs geballt. Dies zeigt jenseits von lokalen Analysen, dass tropische Wirbelstürme und / oder Überschwemmungen im RUCF weder schnelles Bevölkerungswachstum noch städtische Expansion verhindern. Ich schlage Einstiegspunkte für die Skalierung erfolgreicher Strategien zur Reduzierung von Vulnerabilität in Küstenstädten innerhalb des gleichen Vulnerabilitätsprofils vor. Diese Dissertation zeigt, dass Flickenteppiche lokaler Vulnerabilitätsanalysen verallgemeinert werden können, um globale sozioökologische Vulnerabilitäten in ländlichen und städtischen sozioökologischen Systemen nach typischen Problemstrukturen zu systematisieren. In Bezug auf klimatische Extremereignisse drohen sich entgegenstehende Problemstrukturen und Mittel, um mit ihnen umzugehen, die Entwicklungslücke zwischen LICs und Ländern mit hohem Einkommen in der RUCF zu vergrößern, wenn erfolgreiche Maßnahmen zur Vulnerabilitätsreduzierung nicht umfassend ausgeweitet werden. Die Erklärungskraft für menschliche Sicherheit in Trockengebieten berechtigt weitere Anwendungen der Methodik über die globale Umweltforschung hinaus. Die Analyse räumlich expliziter globaler Typologien sozio-ökologischer Vulnerabilität ist daher eine sinnvolle Ergänzung zu lokalen Analysen: Die Typologien bieten Einstiegspunkte dafür, welche generischen Maßnahmen wo in Betracht zu ziehen, um typische Problemstrukturen zu reduzieren - einschließlich der unzähligen Orte ohne lokale Analysen. Dies kann begrenzte Zeit und finanzielle Ressourcen für Anpassung unter rapidem globalen Wandel sparen. KW - vulnerability KW - global environmental change KW - patterns KW - drylands KW - indicator-based analysis KW - adaptation KW - Socio-ecological system KW - cluster analysis KW - subnational resolution KW - resource scarcity KW - environment KW - coastal cities KW - coastal urbanization Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-428837 ER - TY - JOUR A1 - Carvalho, Bruna B. A1 - Bartoli, Omar A1 - Ferri, Fabio A1 - Cesare, Bernardo A1 - Ferrero, Silvio A1 - Remusat, Laurent A1 - Capizzi, Luca Samuele A1 - Poli, Stefano T1 - Anatexis and fluid regime of the deep continental crust: New clues from melt and fluid inclusions in metapelitic migmatites from Ivrea Zone (NW Italy) JF - Journal of metamorphic geology N2 - We investigate the inclusions hosted in peritectic garnet from metapelitic migmatites of the Kinzigite Formation (Ivrea Zone, NW Italy) to evaluate the starting composition of the anatectic melt and fluid regime during anatexis throughout the upper amphibolite facies, transition, and granulite facies zones. Inclusions have negative crystal shapes, sizes from 2 to 10 mu m and are regularly distributed in the core of the garnet. Microstructural and micro-Raman investigations indicate the presence of two types of inclusions: crystallized silicate melt inclusions (i.e., nanogranitoids, NI), and fluid inclusions (FI). Microstructural evidence suggests that FI and NI coexist in the same cluster and are primary (i.e., were trapped simultaneously during garnet growth). FI have similar compositions in the three zones and comprise variable proportions of CO2, CH4, and N-2, commonly with siderite, pyrophyllite, and kaolinite, suggesting a COHN composition of the trapped fluid. The mineral assemblage in the NI contains K-feldspar, plagioclase, quartz, biotite, muscovite, chlorite, graphite and, rarely, calcite. Polymorphs such as kumdykolite, cristobalite, tridymite, and less commonly kokchetavite, were also found. Rehomogenized NI from the different zones show that all the melts are leucogranitic but have slightly different compositions. In samples from the upper amphibolite facies, melts are less mafic (FeO + MgO = 2.0-3.4 wt%), contain 860-1700 ppm CO2 and reach the highest H2O contents (6.5-10 wt%). In the transition zone melts have intermediate H2O (4.8-8.5 wt%), CO2 (457-1534 ppm) and maficity (FeO + MgO = 2.3-3.9 wt%). In contrast, melts at granulite facies reach highest CaO, FeO + MgO (3.2-4.7 wt%), and CO2 (up to 2,400 ppm), with H2O contents comparable (5.4-8.3 wt%) to the other two zones. Our results represent the first clear evidence for carbonic fluid-present melting in the Ivrea Zone. Anatexis of metapelites occurred through muscovite and biotite breakdown melting in the presence of a COH fluid, in a situation of fluid-melt immiscibility. The fluid is assumed to have been internally derived, produced initially by devolatilization of hydrous silicates in the graphitic protolith, then as a result of oxidation of carbon by consumption of Fe3+-bearing biotite during melting. Variations in the compositions of the melts are interpreted to result from higher T of melting. The H2O contents of the melts throughout the three zones are higher than usually assumed for initial H2O contents of anatectic melts. The CO2 contents are highest at granulite facies, and show that carbon-contents of crustal magmas are not negligible at high T. The activity of H2O of the fluid dissolved in granitic melts decreases with increasing metamorphic grade. Carbonic fluid-present melting of the deep continental crust represents, together with hydrate-breakdown melting reactions, an important process in the origin of crustal anatectic granitoids. KW - anatexis KW - fluid inclusions KW - fluid regime KW - Ivrea Zone KW - melt inclusions Y1 - 2019 U6 - https://doi.org/10.1111/jmg.12463 SN - 0263-4929 SN - 1525-1314 VL - 37 IS - 7 SP - 951 EP - 975 PB - Wiley CY - Hoboken ER - TY - THES A1 - Kowalski, Gabriele Joanna T1 - Animal movement patterns across habitats BT - connecting biodiversity Y1 - 2019 ER - TY - GEN A1 - Lago, Sol A1 - Namyst, Anna A1 - Jäger, Lena Ann A1 - Lau, Ellen T1 - Antecedent access mechanisms in pronoun processing BT - evidence from the N400 T2 - Postprints der Universität Potsdam Humanwissenschaftliche Reihe N2 - Previous cross-modal priming studies showed that lexical decisions to words after a pronoun were facilitated when these words were semantically related to the pronoun’s antecedent. These studies suggested that semantic priming effectively measured antecedent retrieval during coreference. We examined whether these effects extended to implicit reading comprehension using the N400 response. The results of three experiments did not yield strong evidence of semantic facilitation due to coreference. Further, the comparison with two additional experiments showed that N400 facilitation effects were reduced in sentences (vs. word pair paradigms) and were modulated by the case morphology of the prime word. We propose that priming effects in cross-modal experiments may have resulted from task-related strategies. More generally, the impact of sentence context and morphological information on priming effects suggests that they may depend on the extent to which the upcoming input is predicted, rather than automatic spreading activation between semantically related words. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 568 KW - coreference KW - semantic priming KW - event-related potentials KW - sentence comprehension KW - N400 Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433237 SN - 1866-8364 IS - 568 SP - 641 EP - 661 ER - TY - JOUR A1 - Lago, Sol A1 - Namyst, Anna A1 - Jäger, Lena Ann A1 - Lau, Ellen T1 - Antecedent access mechanisms in pronoun processing BT - evidence from the N400 JF - Language, cognition and neuroscience N2 - Previous cross-modal priming studies showed that lexical decisions to words after a pronoun were facilitated when these words were semantically related to the pronoun's antecedent. These studies suggested that semantic priming effectively measured antecedent retrieval during coreference. We examined whether these effects extended to implicit reading comprehension using the N400 response. The results of three experiments did not yield strong evidence of semantic facilitation due to coreference. Further, the comparison with two additional experiments showed that N400 facilitation effects were reduced in sentences (vs. word pair paradigms) and were modulated by the case morphology of the prime word. We propose that priming effects in cross-modal experiments may have resulted from task-related strategies. More generally, the impact of sentence context and morphological information on priming effects suggests that they may depend on the extent to which the upcoming input is predicted, rather than automatic spreading activation between semantically related words. KW - Coreference KW - semantic priming KW - event-related potentials KW - sentence comprehension KW - N400 Y1 - 2019 U6 - https://doi.org/10.1080/23273798.2019.1566561 SN - 2327-3798 SN - 2327-3801 VL - 34 IS - 5 SP - 641 EP - 661 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Crane, Kylie Ann T1 - Anthropocene Presences and the Limits of Deferral BT - Alexis Wright's Carpentaria and The Swan Book JF - Open library of humanities N2 - Literary criticism, particularly ecocriticism, occupies an uneasy position with regard to activism: reading books (or plays, or poems) seems like a rather leisurely activity to be undertaking if our environment—our planet—is in crisis. And yet, critiquing the narratives that structure worlds and discourses is key to the activities of the (literary) critic in this time of crisis. If this crisis manifests as a ‘crisis of imagination’ (e.g. Ghosh), I argue that this not so much a crisis of the absence of texts that address the environmental disaster, but rather a failure to comprehend the presences of the Anthropocene in the present. To interpret (literary) texts in this framework must entail acknowledging and scrutinising the extent of the incapacity of the privileged reader to comprehend the crisis as presence and present rather than spatially or temporally remote. The readings of the novels Carpentaria (2006) and The Swan Book (2013) by Waanyi writer Alexis Wright (Australia) trace the uneven presences of Anthropocenes in the present by way of bringing future worlds (The Swan Book) to the contemporary (Carpentaria). In both novels, protagonists must forge survival amongst ruins of the present and future: the depicted worlds, in particular the representations of the disenfranchisement of indigenous inhabitants of the far north of the Australian continent, emerge as a critique of the intersections of capitalist and colonial projects that define modernity and its impact on the global climate. Y1 - 2019 U6 - https://doi.org/10.16995/olh.348 SN - 2056-6700 VL - 5 IS - 1 PB - Open library of humanities CY - Cambridge ER - TY - JOUR A1 - Ziesemer, Florence A1 - Hüttel, Alexandra A1 - Balderjahn, Ingo T1 - Anti-Consumption JF - Sustainability N2 - Transcending the conventional debate around efficiency in sustainable consumption, anti-consumption patterns leading to decreased levels of material consumption have been gaining importance. Change agents are crucial for the promotion of such patterns, so there may be lessons for governance interventions that can be learnt from the every-day experiences of those who actively implement and promote sustainability in the field of anti-consumption. Eighteen social innovation pioneers, who engage in and diffuse practices of voluntary simplicity and collaborative consumption as sustainable options of anti-consumption share their knowledge and personal insights in expert interviews for this research. Our qualitative content analysis reveals drivers, barriers, and governance strategies to strengthen anti-consumption patterns, which are negotiated between the market, the state, and civil society. Recommendations derived from the interviews concern entrepreneurship, municipal infrastructures in support of local grassroots projects, regulative policy measures, more positive communication to strengthen the visibility of initiatives and emphasize individual benefits, establishing a sense of community, anti-consumer activism, and education. We argue for complementary action between top-down strategies, bottom-up initiatives, corporate activities, and consumer behavior. The results are valuable to researchers, activists, marketers, and policymakers who seek to enhance their understanding of materially reduced consumption patterns based on the real-life experiences of active pioneers in the field. KW - social innovation KW - sufficiency KW - collaborative consumption KW - expert interview KW - consumer behavior KW - sustainability KW - innovation policy KW - governance for sustainable development KW - consumer education Y1 - 2019 U6 - https://doi.org/10.3390/su11236663 SN - 2071-1050 VL - 11 IS - 23 PB - MDPI CY - Basel ER - TY - GEN A1 - Haß, Ulrike A1 - Herpich, Catrin A1 - Norman, Kristina T1 - Anti-Inflammatory Diets and Fatigue T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Accumulating data indicates a link between a pro-inflammatory status and occurrence of chronic disease-related fatigue. The questions are whether the observed inflammatory profile can be (a) improved by anti-inflammatory diets, and (b) if this improvement can in turn be translated into a significant fatigue reduction. The aim of this narrative review was to investigate the effect of anti-inflammatory nutrients, foods, and diets on inflammatory markers and fatigue in various patient populations. Next to observational and epidemiological studies, a total of 21 human trials have been evaluated in this work. Current available research is indicative, rather than evident, regarding the effectiveness of individuals’ use of single nutrients with anti-inflammatory and fatigue-reducing effects. In contrast, clinical studies demonstrate that a balanced diet with whole grains high in fibers, polyphenol-rich vegetables, and omega-3 fatty acid-rich foods might be able to improve disease-related fatigue symptoms. Nonetheless, further research is needed to clarify conflicting results in the literature and substantiate the promising results from human trials on fatigue. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 803 KW - chronic fatigue KW - cancer KW - fatigue reduction diet KW - probiotics KW - polyphenols KW - omega-3 fatty acids KW - anti-inflammatory nutrition KW - cytokines KW - inflammation KW - myalgic encephalomyelitis Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441172 SN - 1866-8372 IS - 803 ER - TY - JOUR A1 - Haß, Ulrike A1 - Herpich, Catrin A1 - Norman, Kristina T1 - Anti-Inflammatory Diets and Fatigue JF - Nutrients N2 - Accumulating data indicates a link between a pro-inflammatory status and occurrence of chronic disease-related fatigue. The questions are whether the observed inflammatory profile can be (a) improved by anti-inflammatory diets, and (b) if this improvement can in turn be translated into a significant fatigue reduction. The aim of this narrative review was to investigate the effect of anti-inflammatory nutrients, foods, and diets on inflammatory markers and fatigue in various patient populations. Next to observational and epidemiological studies, a total of 21 human trials have been evaluated in this work. Current available research is indicative, rather than evident, regarding the effectiveness of individuals’ use of single nutrients with anti-inflammatory and fatigue-reducing effects. In contrast, clinical studies demonstrate that a balanced diet with whole grains high in fibers, polyphenol-rich vegetables, and omega-3 fatty acid-rich foods might be able to improve disease-related fatigue symptoms. Nonetheless, further research is needed to clarify conflicting results in the literature and substantiate the promising results from human trials on fatigue. KW - chronic fatigue KW - cancer KW - fatigue reduction diet KW - probiotics KW - polyphenols KW - omega-3 fatty acids KW - anti-inflammatory nutrition KW - cytokines KW - inflammation KW - myalgic encephalomyelitis Y1 - 2019 U6 - https://doi.org/10.3390/nu11102315 SN - 2072-6643 VL - 11 IS - 10 PB - MDPI CY - Basel ER - TY - JOUR A1 - Rüdiger, Günther A1 - Küker, Manfred A1 - Kapyla, P. J. A1 - Strassmeier, Klaus G. T1 - Antisolar differential rotation of slowly rotating cool stars JF - Astronomy and astrophysics : an international weekly journal N2 - Rotating stellar convection transports angular momentum towards the equator, generating the characteristic equatorial acceleration of the solar rotation while the radial flux of angular momentum is always inwards. New numerical box simulations for the meridional cross-correlation < u(theta)u(phi)>, however, reveal the angular momentum transport towards the poles for slow rotation and towards the equator for fast rotation. The explanation is that for slow rotation a negative radial gradient of the angular velocity always appears, which in combination with a so-far neglected rotation-induced off-diagonal eddy viscosity term nu(perpendicular to) provides "antisolar rotation" laws with a decelerated equator Similarly, the simulations provided positive values for the rotation-induced correlation < u(r)u(theta)>, which is relevant for the resulting latitudinal temperature profiles (cool or warm poles) for slow rotation and negative values for fast rotation. Observations of the differential rotation of slowly rotating stars will therefore lead to a better understanding of the actual stress-strain relation, the heat transport, and the underlying model of the rotating convection. KW - stars: solar-type KW - convection KW - stars: rotation KW - turbulence Y1 - 2019 U6 - https://doi.org/10.1051/0004-6361/201935280 SN - 1432-0746 VL - 630 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Poghosyan, Armen H. A1 - Adamyan, Maksim P. A1 - Shahinyan, Aram A. A1 - Koetz, Joachim T1 - AOT Bilayer Adsorption on Gold Surfaces BT - A Molecular Dynamics Study JF - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry N2 - A molecular dynamics study was done to reveal the adsorption properties of sodium dioctyl sulfosuccinate (AOT) bilayers on gold Au(111) surfaces. Examining the rotational mobility of AOT molecules, we track that the correlation time of AOT molecules on the adsorbed layer is much higher. The data estimating the diffusive motion of AOT molecule show a substantially lower rate of diffusion (similar to 10(-10) cm(2)/s) in the adsorbed layers in comparison to other ones. The results show that an adsorbed layer is more rigid, whereas the outer layers undergo considerable lateral and vertical fluctuations. Y1 - 2019 U6 - https://doi.org/10.1021/acs.jpcb.8b11471 SN - 1520-6106 VL - 123 IS - 4 SP - 948 EP - 953 PB - American Chemical Society CY - Washington ER - TY - GEN A1 - Hargis, Hailey A1 - Gotsch, Sybil G. A1 - Porada, Philipp A1 - Moore, Georgianne W. A1 - Ferguson, Briana A1 - Van Stan II, John T. T1 - Arboreal epiphytes in the soil-atmosphere interface BT - how often are the biggest “buckets” in the canopy empty? T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Arboreal epiphytes (plants residing in forest canopies) are present across all major climate zones and play important roles in forest biogeochemistry. The substantial water storage capacity per unit area of the epiphyte “bucket” is a key attribute underlying their capability to influence forest hydrological processes and their related mass and energy flows. It is commonly assumed that the epiphyte bucket remains saturated, or near-saturated, most of the time; thus, epiphytes (particularly vascular epiphytes) can store little precipitation, limiting their impact on the forest canopy water budget. We present evidence that contradicts this common assumption from (i) an examination of past research; (ii) new datasets on vascular epiphyte and epi-soil water relations at a tropical montane cloud forest (Monteverde, Costa Rica); and (iii) a global evaluation of non-vascular epiphyte saturation state using a process-based vegetation model, LiBry. All analyses found that the external and internal water storage capacity of epiphyte communities is highly dynamic and frequently available to intercept precipitation. Globally, non-vascular epiphytes spend <20% of their time near saturation and regionally, including the humid tropics, model results found that non-vascular epiphytes spend ~1/3 of their time in the dry state (0–10% of water storage capacity). Even data from Costa Rican cloud forest sites found the epiphyte community was saturated only 1/3 of the time and that internal leaf water storage was temporally dynamic enough to aid in precipitation interception. Analysis of the epi-soils associated with epiphytes further revealed the extent to which the epiphyte bucket emptied—as even the canopy soils were often <50% saturated (29–53% of all days observed). Results clearly show that the epiphyte bucket is more dynamic than currently assumed, meriting further research on epiphyte roles in precipitation interception, redistribution to the surface and chemical composition of “net” precipitation waters reaching the surface. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 928 KW - precipitation KW - interception KW - bromeliad KW - vascular epiphyte KW - non-vascular epiphyte KW - lichens KW - bryophytes KW - water storage capacity Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-441993 SN - 1866-8372 IS - 928 ER - TY - JOUR A1 - Hargis, Hailey A1 - Gotsch, Sybil G. A1 - Porada, Philipp A1 - Moore, Georgianne W. A1 - Ferguson, Briana A1 - Van Stan, John T. T1 - Arboreal epiphytes in the soil-atmosphere interface BT - how often are the biggest "buckets" in the canopy empty? JF - Geosciences N2 - Arboreal epiphytes (plants residing in forest canopies) are present across all major climate zones and play important roles in forest biogeochemistry. The substantial water storage capacity per unit area of the epiphyte "bucket" is a key attribute underlying their capability to influence forest hydrological processes and their related mass and energy flows. It is commonly assumed that the epiphyte bucket remains saturated, or near-saturated, most of the time; thus, epiphytes (particularly vascular epiphytes) can store little precipitation, limiting their impact on the forest canopy water budget. We present evidence that contradicts this common assumption from (i) an examination of past research; (ii) new datasets on vascular epiphyte and epi-soil water relations at a tropical montane cloud forest (Monteverde, Costa Rica); and (iii) a global evaluation of non-vascular epiphyte saturation state using a process-based vegetation model, LiBry. All analyses found that the external and internal water storage capacity of epiphyte communities is highly dynamic and frequently available to intercept precipitation. Globally, non-vascular epiphytes spend <20% of their time near saturation and regionally, including the humid tropics, model results found that non-vascular epiphytes spend similar to 1/3 of their time in the dry state (0-10% of water storage capacity). Even data from Costa Rican cloud forest sites found the epiphyte community was saturated only 1/3 of the time and that internal leaf water storage was temporally dynamic enough to aid in precipitation interception. Analysis of the epi-soils associated with epiphytes further revealed the extent to which the epiphyte bucket emptied-as even the canopy soils were often <50% saturated (29-53% of all days observed). Results clearly show that the epiphyte bucket is more dynamic than currently assumed, meriting further research on epiphyte roles in precipitation interception, redistribution to the surface and chemical composition of "net" precipitation waters reaching the surface. KW - precipitation KW - interception KW - bromeliad KW - vascular epiphyte KW - non-vascular epiphyte KW - lichens KW - bryophytes KW - water storage capacity Y1 - 2019 U6 - https://doi.org/10.3390/geosciences9080342 SN - 2076-3263 VL - 9 IS - 8 PB - MDPI CY - Basel ER - TY - JOUR A1 - Tomás, Sara A1 - Aurell, Marcos A1 - Badenas, Beatriz A1 - Bjorge, Merle A1 - Duaso, Maria A1 - Mutti, Maria T1 - Architecture and Paleoenvironment of Mid-Jurassic Microbial–Siliceous Sponge Mounds, Northeastern Spain JF - Journal of sedimentary research N2 - The occurrence of mounds dominated by siliceous sponges and microbialites is often related to distal, deep settings of middle ramps and shelves. This paper presents evidence for Bajocian (Garanliana garantiana Zone) microbial-siliceous sponge mounds formed in open marine but relatively shallow settings of a ramp from the Iberian Basin of eastern Spain. Marked differences in mound spacing, morphology, and composition of the related intermound facies are observed from distal to more proximal settings. The distal (below storm wave base) settings are characterized by alternating tabular-bedded marls and limestones rich in pelagic fossils (ammonites, belemnites), open-marine thin-shelled bivalves (Bositra-like), as well as peloids, which include widely or randomly spaced isolated, small (up to 0.4 m high) and larger (up to 2.5 m high) mounds with upward accretion. The intermediate (near to above storm wave base) settings show tabular, thickened beds of peloidal and/or intraclastic limestones with closely spaced mounds (similar to 1 m high), which often coalesce laterally, forming extensive lenticular structures (up to 10 m wide). The proximal (above storm wave base) depositional settings consist of tabular to irregular beds of intraclastic limestones with widely spaced small (up to 0.4 m high) mounds with mainly tabular geometries. The mound framework contains variable proportions of microbialites (dense to clotted peloidal thrombolitic fabrics) and siliceous sponges (hexactinellids and lithistids in similar proportion) ranging from planar to conic shapes. These morphological and compositional changes allow characterizing three shallowing-upward sequences (sequences 1-3) developed in the overall regressive trend of a basin-wide, upper Bajocian T-R cycle. Episodic wave reworking of the early-cemented mounds resulted in the formation of peloids, small rounded intraclasts, and large, rounded or subangular intraclasts. These nonskeletal micritic grains show internal fabrics related to those of the mound and/or microbialites. A progressive textural gradation towards greater size and lesser roundness of the nonskeletal grains in the areas in the vicinity of the main mound factory is documented (i.e., from large, subangular intraclasts in the areas close to the main mound factory to peloids in the areas that are far from it). We discuss the alternative model of internal waves (instead of storm-induced waves) as the hydrodynamic agent providing the high-energy events needed to explain the origin of the peloidal-intraclastic intermound facies and, likely, also the nutrients needed by the microbialites and siliceous sponges to grow. Y1 - 2019 U6 - https://doi.org/10.2110/jsr.2019.5 SN - 1527-1404 SN - 1938-3681 VL - 89 IS - 2 SP - 110 EP - 134 PB - Society for Sedimentary Geology CY - Tulsa ER - TY - JOUR A1 - Westphal, Andrea A1 - Vock, Miriam A1 - Lazarides, Rebecca T1 - Are more conscientious seventh- and ninth-graders less likely to be retained? BT - effects of big five personality traits on grade retention in two different age cohorts JF - Journal of applied developmental psychology : an internat. multidisciplinary N2 - Previous research has identified students' personality traits, especially conscientiousness, as highly relevant predictors of academic success. Less is known about the role of Big Five personality traits in students when it comes to teachers' decisions about students' educational trajectories and whether personality traits differentially affect these decisions by teachers in different grade levels. This study examines to what extent students' Big Five personality traits affect teacher decisions on grade retention, looking at two cohorts of 12,146 ninth-grade and 6002 seventh-grade students from the German National Educational Panel Study. In both grade levels, multilevel logistic mediation models show that students' conscientiousness indirectly predicts grade retention through the assignment of grades by teachers. In the ninth-grade sample, students' conscientiousness was additionally a direct predictor of retention, distinct from teacher-assigned grades. We discuss potential underlying mechanisms and explore whether teachers base their decisions on different indicators when retaining seventh-grade students or ninth-grade students. KW - grade retention KW - personality KW - gender KW - socioeconomic status KW - educational KW - large-scale study KW - educational achievement Y1 - 2019 U6 - https://doi.org/10.1016/j.appdev.2019.101088 SN - 0193-3973 VL - 66 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Ponce, Carol Barahona A1 - Scherer, Dominique A1 - Boekstegers, Felix A1 - Garate-Calderon, Valentina A1 - Jenab, Mazda A1 - Aleksandrova, Krasimira A1 - Katzke, Verena A1 - Weiderpass, Elisabete A1 - Bonet, Catalina A1 - Moradi, Tahereh A1 - Fischer, Krista A1 - Bossers, Willem A1 - Brenner, Hermann A1 - Schöttker, Ben A1 - Holleczek, Bernd A1 - Hveem, Kristian A1 - Eklund, Niina A1 - Voelker, Uwe A1 - Waldenberger, Melanie A1 - Bermejo, Justo Lorenzo T1 - Arsenic and gallbladder cancer risk BT - Mendelian randomization analysis of European prospective data T2 - International journal of cancer KW - arsenic KW - gallbladder cancer KW - Mendelian randomization Y1 - 2019 U6 - https://doi.org/10.1002/ijc.32837 SN - 0020-7136 SN - 1097-0215 VL - 146 IS - 9 SP - 2648 EP - 2650 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Demske, Ulrike T1 - Aspectual features and categorial shift BT - deverbal nominals in German and English JF - Language sciences N2 - The point of departure of this paper is the claim by Heyvaert, Maekelberghe & Buyle (2019) that the suffix -ing has no aspectual meaning in English gerunds. Rather, the interpretation of nominal and verbal gerunds depends, so they argue, on situation or viewpoint aspect, a claim that contradicts the wide-spread view that the aspectual meaning of English gerunds is brought about by the nominalizing suffix. The present paper addresses the issue from a comparative perspective, focusing on German ung-nominals: while they share aspectual features with their English counterparts, empirical evidence from productivity, distribution, and argument linking shows (i) that the derivational suffix -ung imposes aspectual restrictions on possible verb bases, and (ii) that with respect to argument linking, the deverbal nominal favors the state component of a complex event predicate over its process component. From the historical record of German, we learn that these aspectual restrictions do not hold for ung-nominals in earlier periods of German. With the rise of aspectual restrictions, the nominalization pattern turns more nominal resulting in a position further towards the nominal end of the deverbalization continuum. It appears, then, that it is only in the historical pariods of German that ung-nominals pattern with English nominals as regards their aspectual features. Currently, German ung-nominals are more noun-like than nominal (and verbal) gerunds in English. (C) 2018 Elsevier Ltd. All rights reserved. Y1 - 2019 U6 - https://doi.org/10.1016/j.langsci.2018.08.006 SN - 0388-0001 SN - 1873-5746 VL - 73 SP - 50 EP - 61 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - König, Jeannette A1 - Grune, Tilman A1 - Ott, Christiane T1 - Assessing autophagy in murine skeletal muscle: current findings to modulate and quantify the autophagic flux JF - Current opinion in clinical nutrition and metabolic care N2 - Purpose of review In addition to the currently available lysosomotropic drugs and autophagy whole-body knockout mouse models, we provide alternative methods that enable the modulation and detection of autophagic flux in vivo, discussing advantages and disadvantages of each method. Recent findings With the autophagosome-lysosome fusion inhibitor colchicine in skeletal muscle and temporal downregulation of autophagy using a novel Autophagy related 5-short hairpin RNA (Atg5-shRNA) mouse model we mention two models that directly modulate autophagy flux in vivo. Furthermore, methods to quantify autophagy flux, such as mitophagy transgenic reporters, in situ immunofluorescent staining and multispectral imaging flow cytometry, in mature skeletal muscle and cells are addressed. To achieve clinical benefit, less toxic, temporary and cell-type-specific modulation of autophagy should be pursued further. A temporary knockdown as described for the Atg5-shRNA mice could provide a first insight into possible implications of autophagy inhibition. However, it is also important to take a closer look into the methods to evaluate autophagy after harvesting the tissue. In particular caution is required when experimental conditions can influence the final measurement and this should be pretested carefully. KW - autophagy flux KW - in vivo KW - skeletal muscle Y1 - 2019 U6 - https://doi.org/10.1097/MCO.0000000000000579 SN - 1363-1950 SN - 1473-6519 VL - 22 IS - 5 SP - 355 EP - 362 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Wendi, Dadiyorto A1 - Merz, Bruno A1 - Marwan, Norbert T1 - Assessing hydrograph similarity and rare runoff dynamics by cross recurrence plots JF - Water resources research N2 - This paper introduces a novel measure to assess similarity between event hydrographs. It is based on cross recurrence plots (CRP) and recurrence quantification analysis (RQA), which have recently gained attention in a range of disciplines when dealing with complex systems. The method attempts to quantify the event runoff dynamics and is based on the time delay embedded phase space representation of discharge hydrographs. A phase space trajectory is reconstructed from the event hydrograph, and pairs of hydrographs are compared to each other based on the distance of their phase space trajectories. Time delay embedding allows considering the multidimensional relationships between different points in time within the event. Hence, the temporal succession of discharge values is taken into account, such as the impact of the initial conditions on the runoff event. We provide an introduction to cross recurrence plots and discuss their parameterization. An application example based on flood time series demonstrates how the method can be used to measure the similarity or dissimilarity of events, and how it can be used to detect events with rare runoff dynamics. It is argued that this methods provides a more comprehensive approach to quantify hydrograph similarity compared to conventional hydrological signatures. KW - runoff dynamics KW - cross recurrence plot in hydrology KW - rare flood dynamics KW - hydrograph similarity KW - time delay embedding for runoff series Y1 - 2019 U6 - https://doi.org/10.1029/2018WR024111 SN - 0043-1397 SN - 1944-7973 VL - 55 IS - 6 SP - 4704 EP - 4726 PB - American Geophysical Union CY - Washington ER - TY - THES A1 - Grishina, Yulia T1 - Assessing the applicability of annotation projection methods for coreference relations T1 - Analyse der Qualität von Annotationsprojektionsmethoden für Koreferenzrelationen N2 - The main goal of this thesis is to explore the feasibility of using cross-lingual annotation projection as a method of alleviating the task of manual coreference annotation. To reach our goal, we build a first trilingual parallel coreference corpus that encompasses multiple genres. For the annotation of the corpus, we develop common coreference annotation guidelines that are applicable to three languages (English, German, Russian) and include a novel domain-independent typology of bridging relations as well as state-of-the-art near-identity categories. Thereafter, we design and perform several annotation projection experiments. In the first experiment, we implement a direct projection method with only one source language. Our results indicate that, already in a knowledge-lean scenario, our projection approach is superior to the most closely related work of Postolache et al. (2006). Since the quality of the resulting annotations is to a high degree dependent on the word alignment, we demonstrate how using limited syntactic information helps to further improve mention extraction on the target side. As a next step, in our second experiment, we show how exploiting two source languages helps to improve the quality of target annotations for both language pairs by concatenating annotations projected from two source languages. Finally, we assess the projection quality in a fully automatic scenario (using automatically produced source annotations), and propose a pilot experiment on manual projection of bridging pairs. For each of the experiments, we carry out an in-depth error analysis, and we conclude that noisy word alignments, translation divergences and morphological and syntactic differences between languages are responsible for projection errors. We systematically compare and evaluate our projection methods, and we investigate the errors both qualitatively and quantitatively in order to identify problematic cases. Finally, we discuss the applicability of our method to coreference annotations and propose several avenues of future research. N2 - Ziel dieser Dissertation ist, die Durchführbarkeit von crosslingualer Annotationsprojektion als Methode zur Erleichterung der manuellen Koreferenzannotation zu erproben. Um dieses Ziel zu erreichen, wird das erste dreisprachige parallele Koreferenzkorpus gebaut, das mehrere Textsorten umfasst. Für die Korpusannotation werden gemeinsame Annotationsrichtlinien entwickelt, die auf drei Sprachen anwendbar sind (Englisch, Deutsch, Russisch) und eine neue domänenunabhängige Typologie von indirekten Wiederaufnahmen und sogenannten Near-Identity-Kategorien enthalten. Danach werden mehrere Projektionsexperimente entworfen und durchgeführt. Im ersten Experiment wird eine direkte Projektionsmethode mit nur einer Ausgangs\-sprache implementiert. Die Ergebnisse zeigen, dass bereits in einem wissensarmen Szenario der vorgeschlagene Projektionsansatz die Resultate der verwandten Arbeit von Postolache et al. (2006) übertrifft. Da die Qualität der resultierenden Annotationen in hohem Maße von der Wortalignierung abhängig ist, zeigen wir, wie die Verwendung begrenzter syntaktischer Informationen weiterhilft, die Extraktion von referierenden Ausdrücken auf der Zielseite zu verbessern. Im nächsten Schritt, dem zweiten Experiment, demonstrieren wir, wie die Nutzung von zwei Ausgangssprachen zur weiteren Verbesserung der Qualität der Zielannotationen für beide Sprachpaare beiträgt, indem die Annotationen aus zwei Quellsprachen kombiniert werden. Schließlich wird die Projektionsqualität noch in einem vollautomatischen Szenario ausgewertet (mit automatisch erstellten Quellannotationen), und ein Pilotversuch zur manuellen Projektion von Paaren indirekter Wiederaufnahmen vorgestellt. Für jedes Experiment wird eine detaillierte Fehleranalyse durchgeführt. Daraus schließen wir, dass fehlerhafte Wortalignierungen, Übersetzungsdivergenzen und morphologische sowie syntaktische Unterschiede zwischen den Sprachen für die Projektionsfehler verantwortlich sind. Hierzu werden die Projektionsmethoden systematisch verglichen und ausgewertet, und die Fehler sowohl qualitativ als auch quantitativ untersucht, um problematische Fälle zu identifizieren. Zum Schluss wird die Anwendbarkeit unserer Methode für Koreferenzannotationen diskutiert, und es werden Ansatzpunkte für weitere Forschung vorgeschlagen. KW - annotation KW - annotation projection KW - bridging KW - near-identity KW - coreference resolution KW - multilingual coreference KW - coreference corpus KW - Annotation KW - Annotationsprojektion KW - Koreferenz KW - indirekte Wiederaufnahmen KW - Near-identity KW - Koreferenzauflösung KW - multilinguale Koreferenz KW - Koreferenzkorpus Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-425378 ER - TY - JOUR A1 - Junga, Yvonne Marie A1 - Witthöft, Michael A1 - Weck, Florian T1 - Assessing therapist development: Reliability and validity of the Supervisee Levels Questionnaire (SLQ-R) JF - Journal of clinical psychology KW - clinical supervision KW - exploratory structural equation modeling KW - psychotherapy training KW - Supervisee Levels Questionnaire Y1 - 2019 U6 - https://doi.org/10.1002/jclp.22794 SN - 0021-9762 SN - 1097-4679 VL - 75 IS - 9 SP - 1658 EP - 1672 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Muschalla, Beate A1 - Poguntke, Kim Joy A1 - Linden, Michael T1 - Assessment of Capacity Impairment in Patients with Mental Disorders by Routine Clinical Assessment and by Structured Assessment with the Mini-ICF-APP JF - Psychopathology N2 - Background: Physicians and therapists are also consulted to give judgments on working ability. Ability to work cannot simply be derived from the patient’s symptom status but from the illness-related capacity impairments in relation to the work demands. A structured assessment of capacity impairments has been evaluated and applied internationally: the Mini-ICF-APP Social Functioning Scale. It is currently unclear whether a free-text clinical report (i.e., usual clinical practice: clinical exploration according to clinical standards, but without a standardized documentation form, instead a text is written) and a structured capacity assessment correspond to the overall work ability judgment, i.e., the decision whether a patient is “fit for work” or “unfit for work.” Objectives: This investigation assessed, for the first time, whether usual clinical judgment and the additional structured capacity rating support the work ability decision. Methods: A total of 100 medical reports from patients in a psychotherapy hospital were excerpted for psychopathological symptoms and capacity disorders using a checklist. Additionally, a structured assessment of capacity disorders was documented on the Mini-ICF-APP rating for all patients. Results: In the free-text clinical medical report, endurance, flexibility, and contacts to others were the things mainly reported as impaired. This was similar to the structured Mini-ICF-APP rating. However, other capacity impairments were also reported in the Mini-ICF-APP, i.e., adherence to rules and regulations, planning and structuring, assertiveness, and group integration. When the free-text clinical report and the structured Mini-ICF-APP rating were compared, there was a higher rate of stated impairments covering all capacity dimensions in the Mini-ICF-APP rating. Conclusions: The free-text report in the medical report shows the differences between patients who are fit for work and those who are not, and thus speak for the validity of work ability decisions. However, optimization is possible in terms of depth and differentiation of capacity impairment description by adhering to the standard set by the Mini-ICF-APP. KW - Mini-ICF-APP KW - Capacity KW - Disability KW - General practice KW - Mental disorder KW - Clinical judgment KW - Work ability Y1 - 2019 U6 - https://doi.org/10.1159/000502123 SN - 0254-4962 SN - 1423-033X VL - 52 IS - 4 SP - 248 EP - 255 PB - Karger CY - Basel ER - TY - JOUR A1 - Baroni, Gabriele A1 - Drastig, Katrin A1 - Lichtenfeld, Anna-Ulrike A1 - Jost, Leonie A1 - Claas, Peter T1 - Assessment of irrigation scheduling systems in Germany BT - survey of the users and comparative study JF - Irrigation and drainage N2 - In Germany, the irrigation sector accounts for only 1% of water use. In recent years, however, this sector has attracted more attention due to the occurrence of severe drought periods. Irrigation scheduling systems could support adaptation strategies but little is known about current providers, performance and users. In this study we aimed to depict the current situation of the existence and functioning of irrigation scheduling systems available in Germany. Six methods were identified and assessed based on direct interviews with end-users and a comparative analysis. The results showed a positive feedback from the users. However, the recommendations were rarely implemented, while only the seasonal irrigation requirement was considered to support actual water abstraction. These results were corroborated by the comparative analysis. Five of the six irrigation scheduling systems estimated the seasonal irrigation amount consistently, while wider differences were found by looking at the irrigation season and at the number of irrigations. Overall, it is found that irrigation support systems are valuable tools for supporting adaptation strategies to fast changes in agro-environmental conditions. However, specific assessments based on real measurements should be considered in order to improve the performance of the systems and provide more consistent support to end-users. (c) 2019 John Wiley & Sons, Ltd. KW - irrigation KW - modelling systems KW - surveys KW - assessment KW - Germany Y1 - 2019 U6 - https://doi.org/10.1002/ird.2337 SN - 1531-0353 SN - 1531-0361 VL - 68 IS - 3 SP - 520 EP - 530 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Milewski, Robert A1 - Chabrillat, Sabine A1 - Brell, Maximillian A1 - Schleicher, Anja Maria A1 - Guanter, Luis T1 - Assessment of the 1.75μm absorption feature for gypsum estimation using laboratory, air- and spaceborne hyperspectral sensors JF - International Journal of Applied Earth Observation and Geoinformation N2 - High spectral resolution (hyperspectral) remote sensing has already demonstrated its capabilities for soil constituent mapping based on absorption feature parameters. This paper tests different parametrizations of the 1.75 μm gypsum feature for the determination of gypsum abundances, from the laboratory to remote sensing applications of recent as well as upcoming hyperspectral sensors. In particular, this study focuses on remote sensing imagery over the large body of the Omongwa pan located in the Namibian Kalahari. Four common absorption feature parameters are compared: band ratio through the introduction of the Normalized Differenced Gypsum Index (NDGI), the shape-based parameters Slope, and Half-Area, and the Continuum Removed Absorption Depth (CRAD). On laboratory soil samples from the pan, CRAD and NDGI approaches perform best to determine gypsum content tested in cross validated regression models with XRD mineralogical data (R² = 0.84 for NDGI and R² = 0.86 for CRAD). Subsequently the laboratory prediction functions are transferred to remote sensing imagery of spaceborne Hyperion, airborne HySpex and simulated spaceborne EnMAP sensor. Variable results were obtained depending on sensor characteristics, data quality, preprocessing and spectral parameters. Overall, the CRAD parameter in this wavelength region proved not to be robust for remote sensing applications, and the simple band ratio based parameter, the NDGI, proved robust and is recommended for future use for the determination of gypsum content in bare soils based on remote sensing hyperspectral imagery. KW - Hyperspectral KW - Gypsum quantification KW - Salt pan KW - Absorption feature parameters KW - Namibia Y1 - 2017 U6 - https://doi.org/10.1016/j.jag.2018.12.012 SN - 0303-2434 VL - 77 SP - 69 EP - 83 PB - Elsevier Science CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Pereira, Bruno A1 - Medeiros, Pedro Henrique Augusto A1 - Francke, Till A1 - Ramalho, Geraldo A1 - Förster, Saskia A1 - De Araujo, Jose Carlos T1 - Assessment of the geometry and volumes of small surface water reservoirs by remote sensing in a semi-arid region with high reservoir density JF - Hydrological sciences journal = Journal des sciences hydrologiques N2 - Water fluxes in highly impounded regions are heavily dependent on reservoir properties. However, for large and remote areas, this information is often unavailable. In this study, the geometry and volume of small surface reservoirs in the semi-arid region of Brazil were estimated using terrain and shape attributes extracted by remote sensing. Regression models and data classification were used to predict the volumes, at different water stages, of 312 reservoirs for which topographic information is available. The power function used to describe the reservoir shapes tends to overestimate the volumes; therefore, a modified shape equation was proposed. Among the methods tested, four were recommended based on performance and simplicity, for which the mean absolute percentage errors varied from 24 to 39%, in contrast to the 94% error achieved with the traditional method. Despite the challenge of precisely deriving the flooded areas of reservoirs, water management in highly reservoir-dense environments should benefit from volume prediction based on remote sensing. KW - reservoir volume KW - high-density reservoir network KW - water height-area-volume curve KW - semi-arid KW - remote sensing Y1 - 2019 U6 - https://doi.org/10.1080/02626667.2019.1566727 SN - 0262-6667 SN - 2150-3435 VL - 64 IS - 1 SP - 66 EP - 79 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Awan, Asad Bashir A1 - Schiebel, Juliane A1 - Boehm, Alexander A1 - Nitschke, Joerg A1 - Sarwar, Yasra A1 - Schierack, Peter A1 - Ali, Aamir T1 - Association of biofilm formation and cytotoxic potential with multidrug resistance in clinical isolates of pseudomonas aeruginosa JF - EXCLI Journal N2 - Multidrug resistant (MDR) Pseudomonas aeruginosa having strong biofilm potential and virulence factors are a serious threat for hospitalized patients having compromised immunity In this study, 34 P. aeruginosa isolates of human origin (17 MDR and 17 non-MDR clinical isolates) were checked for biofilm formation potential in enriched and minimal media. The biofilms were detected using crystal violet method and a modified software package of the automated VideoScan screening method. Cytotoxic potential of the isolates was also investigated on HepG2, LoVo and T24 cell lines using automated VideoScan technology. Pulse field gel electrophoresis revealed 10 PFGE types in MDR and 8 in non-MDR isolates. Although all isolates showed biofilm formation potential, strong biofilm formation was found more in enriched media than in minimal media. Eight MDR isolates showed strong biofilm potential in both enriched and minimal media by both detection methods. Strong direct correlation between crystal violet and VideoScan methods was observed in identifying strong biofilm forming isolates. High cytotoxic effect was observed by 4 isolates in all cell lines used while 6 other isolates showed high cytotoxic effect on T24 cell line only. Strong association of multidrug resistance was found with biofilm formation as strong biofilms were observed significantly higher in MDR isolates (p-value < 0.05) than non-MDR isolates. No significant association of cytotoxic potential with multidrug resistance or biofilm formation was found (p-value > 0.05). The MDR isolates showing significant cytotoxic effects and strong biofilm formation impose a serious threat for hospitalized patients with weak immune system. KW - Pseudomonas aeruginosa KW - multidrug resistance KW - biofilm KW - cytotoxicity KW - VideoScan technology Y1 - 2019 U6 - https://doi.org/10.17179/excli2018-1948 SN - 1611-2156 VL - 18 SP - 79 EP - 90 PB - Leibniz Research Centre for Working Environment and Human Factors CY - Dortmund ER - TY - JOUR A1 - Eichelmann, Fabian A1 - Schulze, Matthias Bernd A1 - Wittenbecher, Clemens A1 - Menzel, Juliane A1 - Weikert, Cornelia A1 - di Giuseppe, Romina A1 - Biemann, Ronald A1 - Isermann, Berend A1 - Fritsche, Andreas A1 - Boeing, Heiner A1 - Aleksandrova, Krasimira T1 - Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer JF - JAMA network open N2 - IMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. CONCLUSIONS AND RELEVANCE This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis. Y1 - 2019 U6 - https://doi.org/10.1001/jamanetworkopen.2019.0896 SN - 2574-3805 VL - 2 IS - 3 PB - American Veterinary Medical Association CY - Chicago ER - TY - JOUR A1 - Ashton, Michelle P. A1 - Eugster, Anne A1 - Dietz, Sevina A1 - Loebel, Doreen A1 - Lindner, Annett A1 - Kuehn, Denise A1 - Taranko, Anna E. A1 - Heschel, Babett A1 - Gavrisan, Anita A1 - Ziegler, Anette-Gabriele A1 - Aringer, Martin A1 - Bonifacio, Ezio T1 - Association of Dendritic Cell Signatures With Autoimmune Inflammation Revealed by Single-Cell Profiling JF - Arthrittis & Rheumatology Y1 - 2018 U6 - https://doi.org/10.1002/art.40793 SN - 2326-5191 SN - 2326-5205 VL - 71 IS - 5 SP - 817 EP - 828 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Wachs, Sebastian A1 - Wright, Michelle F. A1 - Sittichai, Ruthaychonnee A1 - Singh, Ritu A1 - Biswal, Ramakrishna A1 - Kim, Eun-mee A1 - Yang, Soeun A1 - Gámez-Guadix, Manuel A1 - Almendros, Carmen A1 - Flora, Katerina A1 - Daskalou, Vassiliki A1 - Maziridou, Evdoxia T1 - Associations between Witnessing and Perpetrating Online Hate in Eight Countries BT - The Buffering Effects of Problem-Focused Coping T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Online hate is a topic that has received considerable interest lately, as online hate represents a risk to self-determination and peaceful coexistence in societies around the globe. However, not much is known about the explanations for adolescents posting or forwarding hateful online material or how adolescents cope with this newly emerging online risk. Thus, we sought to better understand the relationship between a bystander to and perpetrator of online hate, and the moderating effects of problem-focused coping strategies (e.g., assertive, technical coping) within this relationship. Self-report questionnaires on witnessing and committing online hate and assertive and technical coping were completed by 6829 adolescents between 12 and 18 years of age from eight countries. The results showed that increases in witnessing online hate were positively related to being a perpetrator of online hate. Assertive and technical coping strategies were negatively related with perpetrating online hate. Bystanders of online hate reported fewer instances of perpetrating online hate when they reported higher levels of assertive and technical coping strategies, and more frequent instances of perpetrating online hate when they reported lower levels of assertive and technical coping strategies. In conclusion, our findings suggest that, if effective, prevention and intervention programs that target online hate should consider educating young people about problem-focused coping strategies, self-assertiveness, and media skills. Implications for future research are discussed. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 592 KW - online hate KW - hate speech KW - bystander KW - perpetrator KW - coping strategies KW - cyber aggression Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-442294 SN - 1866-8364 IS - 592 ER -