TY  - JOUR
A1  - Mai, Tobias
A1  - Wolski, Karol
A1  - Puciul-Malinowska, Agnieszka
A1  - Kopyshev, Alexey
A1  - Gräf, Ralph
A1  - Bruns, Michael
A1  - Zapotoczny, Szczepan
A1  - Taubert, Andreas
T1  - Anionic polymer brushes for biomimetic calcium phosphate mineralization
BT  - A surface with application potential in biomaterials
JF  - Polymers
N2  - This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.
KW  - polymer brushes
KW  - calcium phosphate
KW  - hydroxyapatite
KW  - carbonated apatite
KW  - bone mimic
KW  - biocompatibility
KW  - Dictyostelium discoideum
Y1  - 2018
U6  - https://doi.org/10.3390/polym10101165
SN  - 2073-4360
VL  - 10
IS  - 10
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Schneider, Matthias
A1  - Günter, Christina
A1  - Taubert, Andreas
T1  - Co-deposition of a hydrogel/calcium phosphate hybrid layer on 3D printed poly(lactic acid) scaffolds via dip coating
BT  - Towards automated biomaterials fabrication
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The article describes the surface modification of 3D printed poly(lactic acid) (PLA) scaffolds with calcium phosphate (CP)/gelatin and CP/chitosan hybrid coating layers. The presence of gelatin or chitosan significantly enhances CP co-deposition and adhesion of the mineral layer on the PLA scaffolds. The hydrogel/CP coating layers are fairly thick and the mineral is a mixture of brushite, octacalcium phosphate, and hydroxyapatite. Mineral formation is uniform throughout the printed architectures and all steps (printing, hydrogel deposition, and mineralization) are in principle amenable to automatization. Overall, the process reported here therefore has a high application potential for the controlled synthesis of biomimetic coatings on polymeric biomaterials.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1057 
KW  - 3D printing
KW  - dip-coating
KW  - poly(lactic acid)
KW  - PLA
KW  - calcium phosphate
KW  - gelatin
KW  - chitosan
KW  - hydrogel
KW  - calcium phosphate hybrid material
KW  - biomaterials
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-474427
SN  - 1866-8372
IS  - 1057
ER  - 
TY  - JOUR
A1  - Schneider, Matthias
A1  - Günter, Christina
A1  - Taubert, Andreas
T1  - Co-deposition of a hydrogel/calcium phosphate hybrid layer on 3D printed poly(lactic acid) scaffolds via dip coating
BT  - Towards Automated Biomaterials Fabrication
JF  - Polymers
N2  - The article describes the surface modification of 3D printed poly(lactic acid) (PLA) scaffolds with calcium phosphate (CP)/gelatin and CP/chitosan hybrid coating layers. The presence of gelatin or chitosan significantly enhances CP co-deposition and adhesion of the mineral layer on the PLA scaffolds. The hydrogel/CP coating layers are fairly thick and the mineral is a mixture of brushite, octacalcium phosphate, and hydroxyapatite. Mineral formation is uniform throughout the printed architectures and all steps (printing, hydrogel deposition, and mineralization) are in principle amenable to automatization. Overall, the process reported here therefore has a high application potential for the controlled synthesis of biomimetic coatings on polymeric biomaterials.
KW  - 3D printing
KW  - dip-coating
KW  - poly(lactic acid)
KW  - PLA
KW  - calcium phosphate
KW  - gelatin
KW  - chitosan
KW  - hydrogel
KW  - calcium phosphate hybrid material
KW  - biomaterials
Y1  - 2018
U6  - https://doi.org/10.3390/polym10030275
SN  - 2073-4360
VL  - 10
IS  - 3
PB  - MDPI
CY  - Basel
ER  -