TY  - JOUR
A1  - Bogin, Barry
A1  - Varea, Carlos
A1  - Hermanussen, Michael
A1  - Scheffler, Christiane
T1  - Human life course biology
BT  - a centennial perspective of scholarship on the human pattern of physical growth and its place in human biocultural evolution
JF  - American journal of physical anthropology
KW  - adolescence
KW  - childhood
KW  - life history
KW  - menopause
KW  - senescence
Y1  - 2018
U6  - https://doi.org/10.1002/ajpa.23357
SN  - 0002-9483
SN  - 1096-8644
VL  - 165
IS  - 4
SP  - 834
EP  - 854
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Sadowska, Aleksandra
A1  - Hausmann, Oliver Nic
A1  - Wuertz-Kozak, Karin
T1  - Inflammaging in the intervertebral disc
T2  - Postprints der Universität Potsdam : Mathematisch Naturwissenschaftliche Reihe
N2  - Degeneration of the intervertebral disc – triggered by ageing, mechanical stress, traumatic injury, infection, inflammation and other factors – has a significant role in the development of low back pain. Back pain not only has a high prevalence, but also a major socio-economic impact. With the ageing population, its occurrence and costs are expected to grow even more in the future. Disc degeneration is characterized by matrix breakdown, loss in proteoglycans and thus water content, disc height loss and an increase in inflammatory molecules. The accumulation of cytokines, such as interleukin (IL)-1 , IL-8 or tumor necrosis factor (TNF)-, together with age-related immune deficiency, leads to the so-called inflammaging – low-grade, chronic inflammation with a crucial role in pain development. Despite the relevance of these molecular processes, current therapies target symptoms, but not underlying causes. This review describes the biological and biomechanical changes that occur in a degenerated disc, discusses the connection between disc degeneration and inflammaging, highlights factors that enhance the inflammatory processes in disc pathologies and suggests future research avenues.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 519 
KW  - Intervertebral disc
KW  - chronic inflammation
KW  - inflammaging
KW  - senescence
KW  - mechanical loading
KW  - matrix fragmentation
KW  - obesity
KW  - Propionibacterium acnes
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414081
IS  - 519
ER  - 
TY  - JOUR
A1  - Kamranfar, Iman
A1  - Xue, Gang-Ping
A1  - Tohge, Takayuki
A1  - Sedaghatmehr, Mastoureh
A1  - Fernie, Alisdair R.
A1  - Balazadeh, Salma
A1  - Mueller-Roeber, Bernd
T1  - Transcription factor RD26 is a key regulator of metabolic reprogramming during dark-induced senescence
JF  - New phytologist : international journal of plant science
N2  - Leaf senescence is a key process in plants that culminates in the degradation of cellular constituents and massive reprogramming of metabolism for the recovery of nutrients from aged leaves for their reuse in newly developing sinks. We used molecular-biological and metabolomics approaches to identify NAC transcription factor (TF) RD26 as an important regulator of metabolic reprogramming in Arabidopsis thaliana. RD26 directly activates CHLOROPLAST VESICULATION (CV), encoding a protein crucial for chloroplast protein degradation, concomitant with an enhanced protein loss in RD26 over-expressors during senescence, but a reduced decline of protein in rd26 knockout mutants. RD26 also directly activates LKR/SDH involved in lysine catabolism, and PES1 important for phytol degradation. Metabolic profiling revealed reduced c-aminobutyric acid (GABA) in RD26 overexpressors, accompanied by the induction of respective catabolic genes. Degradation of lysine, phytol and GABA is instrumental for maintaining mitochondrial respiration in carbon-limiting conditions during senescence. RD26 also supports the degradation of starch and the accumulation of mono-and disaccharides during senescence by directly enhancing the expression of AMY1, SFP1 and SWEET15 involved in carbohydrate metabolism and transport. Collectively, during senescence RD26 acts by controlling the expression of genes across the entire spectrum of the cellular degradation hierarchy.
KW  - Arabidopsis
KW  - fatty acid
KW  - primary metabolism
KW  - protein and amino acid degradation
KW  - respiration
KW  - senescence
Y1  - 2018
U6  - https://doi.org/10.1111/nph.15127
SN  - 0028-646X
SN  - 1469-8137
VL  - 218
IS  - 4
SP  - 1543
EP  - 1557
PB  - Wiley
CY  - Hoboken
ER  -