TY - JOUR A1 - Ette, Ottmar T1 - "... daß einem leid tut, wie er aufgehört hat, deutsch zu sein " : Alexander von Humboldt, Preußen und Amerika Y1 - 2004 SN - 3-8258-6306-9 ER - TY - JOUR A1 - Ette, Ottmar T1 - "... que uno lamenta, cómo ha dejado de ser alemán" : Alexander von Humboldt, Prusia y América Y1 - 2004 ER - TY - JOUR A1 - Jacobi, Juliane T1 - "August Hermann Francke" Y1 - 2004 SN - 0-02-865915-5 ER - TY - JOUR A1 - Tristram, Hildegard L. C. T1 - "Celtic Studies in Germany, 1980-1995" N2 - This article provides a survey of the research carried out by Celtic scholars in Germany during the 15 years between 1980 and 1995. It is based on the respective bibliography published in 'Studia Celtica Japonica' 9 (1997). The major research fields covered are IE Studies, Celtic philology, linguistics, literature, archaeology and cultural studies. Y1 - 2004 ER - TY - JOUR A1 - Krause, Susanne A1 - Riedel, Peter T1 - "Drei Finger schreiben, der ganze Körper leidet ..." : das mittelalterliche Skriptorium Y1 - 2004 ER - TY - JOUR A1 - Wolf-Bleiß, Birgit T1 - "Es ist mir ein innerer Parteitag, dass das 'Muttiheft' lebt". Wörterbücher zum DDR- Wortschatz Y1 - 2004 SN - 3-7466-8118-9 ER - TY - JOUR A1 - Haußig, Hans-Michael T1 - "Ha-Chagiga Nigmeret" : Naomi Shemer 1930 - 2004 Y1 - 2004 SN - 1614-6492 ER - TY - JOUR A1 - Szaramowicz, Martin T1 - "Hierarchy" und "Scale" : Interessante Denkmuster für die Landschaftsplanung? N2 - Theoretische Ansätze unter den Oberbegriffen "Hierarchy" und "Scale" sind in der Ökologie seit den 1980er-Jahren entwickelt und intensiv diskutiert worden. Das wissenschaftliche Paradigma kann mit dem Begriff "Hierarchical Patch Dynamics" beschrieben werden. Obwohl auch Anwendungsbezüge diskutiert und konzipiert wurden, hat es in Deutschland bisher in der Landschaftsplanung kein größeres Echo hervorgerufen. Gleichwohl gibt es eine Reihe interessanter Anknüpfungspunkte zwischen Aussagen der ökologischen Hierarchie-Theorie und konkreten landschaftsplanerischen und naturschutzfachliceh Aufgabenstellungen. Vor diesem Hintergrund werden Grundzüge dieser Theorie bzw. der unter dem Dach des Paradigmas "Hierarchical Patch Dynamics" versammelten theoretischen Ansätze dargestellt. Wesentlich ist die erkenntnistheoretische Grundhaltung, die versucht, unzulässige Verallgemeinerungen oder Absolutheitsansprüche auszuschließen, indem sie zunächst den Gegenstandsbereich der Ökologie beschreibt und analysiert. Auf dieser Grundlage werden Herangehensweisen zur Behandlung ökologischer Fragestellungen vorgeschlagen. Diese Herangehensweisen lassen sich auf landschaftsplanerische Aufgaben übertragen. Es wird gezeigt, für welche Bereiche eine solche Übertragung denkbar wäre. Letztlich bedürfte es einer Praxisüberprüfung, um herauszufinden, ob mit Hilfe von Ansätzen der ökologischen Hierarchie- Theorie die Bearbeitung planerischer Fragestellungen verbessert oder ergänzt werden könnte. Y1 - 2004 ER - TY - JOUR A1 - Lehnert, Gertrud T1 - "Ich liebe die Klarheit und die Frische" : die dekadente Dichterin Renée Vivien Y1 - 2004 ER - TY - JOUR A1 - Kroener, Bernhard R. T1 - "Nun danket alle Gott" ... "bis zur letzten Patrone" Y1 - 2004 ER - TY - JOUR A1 - Schäfer, Christoph T1 - "Schwebende Wirksamkeit" von Kündigungen N2 - In dem Beitrag geht es um die Frage, ob sich Rechtsgeschäfte im Zustand der schwebenden Wirksamkeit befinden können. Während das Institut der schwebenden Unwirksamkeit allgemein anerkannt ist (z.B. $ 108 Abs. 1 BGB), wird ein diesem entsprechendes Institut der schwebenden Wirksamkeit im BGB durch die Literatur bislang überwiegend geleugnet. Das BAG hat indessen in einem Urteil vom 17.06.2003 die schwebende Wirksamkeit einer Kündigung bejaht. Der Autor geht zunächst der Frage nach, ob das Institut der schwebenden Wirksamkeit existiert, und untersucht sodann, ob das BAG in seinem Urteil für die streitgegenständliche Kündigung dieses Institut zutreffend bejaht hat. Während der Autor die erste Frage bejaht, gelangt er für die Entscheidung des BAG zu dem Ergebnis, daß die Kündigung nicht schwebend wirksam sondern schwebend unwirksam war. Y1 - 2004 SN - 0176-3814 ER - TY - JOUR A1 - Stillmark, Hans-Christian T1 - "Seht seht doch das Fleisch auf der Straße..." : zu intertextuellen Verflechtungen im Werk von Heiner Müller und Peter Weiss Y1 - 2004 SN - 3-86110-380-X ER - TY - JOUR A1 - Schoeps, Julius H. T1 - "Where love is mostly hugger mugger" : Christopher Isherwood, Magnus Hirschfeld und das Berlin am Vorabend der Katastrophe Y1 - 2004 SN - 3-937233-09-1 ER - TY - JOUR A1 - Berner, Elisabeth T1 - "Wie seit undenklichen Zeiten immer dieselbe" - Briefe Emilie Fontanes an ihren Ehemann Theodor Fontane Y1 - 2004 ER - TY - JOUR A1 - Henkel, Carsten A1 - Gardiner, Simon A. A1 - Negretti, Antonio T1 - (De)coherence physics with condensates in microtraps N2 - We discuss the dynamics of a condensate in a miniaturized electromagnetic trap formed above a microstructured substrate. Recent experiments have found that trap lifetimes get reduced when approaching the substrate because atoms couple to thermally excited near fields. The data agree quantitatively with our theory [Appl. Phys. B 69, 379 (1999)]. We focus on the decoherence of a quantum degenerate gas in a quasi-one-dimensional trap. Monte Carlo simulations indicate that atom interactions reduce the condensate decoherence rate. This is explained by a simple theory in terms of the suppression of long-wavelength excitations. We present preliminary simulation results for the adiabatic generation of dark solitons Y1 - 2004 SN - 1054-660X ER - TY - JOUR A1 - Wenzel, Barbara A1 - Wehse, Burkhard A1 - Schilde, Uwe A1 - Strauch, Peter T1 - 1,2-Dithioquadratato- und 1,2-Dithiooxalatoindate(III) = 1,2-dithiosquarato- and 1,2-dithiooxalatoindates(III) N2 - Indium(III) chloride forms in water with potassium 1,2-dithiooxalate (dto) and potassium 1,2-dithiosquarate (dtsq) stable coordination compounds. Due to the higher bridging ability of the 1,2-dithiooxalate ligand in all cases only thiooxalate bridged binuclear complexes were found. From 1,2-dithioquadratate with an identical donor atom set mononuclear trischelates could be isolated. Five crystalline complexes, (BzlMe(3)N)(4)[(dto)(2)In(dto)In(dto)(2)] (1), (BzlPh(3)P)(4)[(dto)(2)In(dto)In(dto)(2)] (2), (BzlMe(3)N)(3)[In(dtsq)(3)] (3), (Bu4N)(3)[In(dtsq)(3)] (4) and (Ph4P)[In(dtsq)(2)(DMF)(2)] (5), have been isolated and characterized by X-ray analyses. Due to the type of the complex and the cations involved these compounds crystallize in different space groups with the following parameters: 1, monoclinic in P2(1)/c with a = 14.4035(5) Angstrom, b = 10.8141(5) Angstrom, c = 23.3698(9) Angstrom, beta = 124.664(2)degrees, and Z = 2; 2, triclinic in P (1) over bar with a = 11.3872(7) Angstrom, b = 13.6669(9) Angstrom, c = 17.4296(10) Angstrom, alpha = 88.883(5)degrees, beta = 96.763(1)degrees, gamma = 74.587(5)degrees, and Z = 1; 3, hexagonal in R3 with a = 20.6501(16) Angstrom, b = 20.6501(16) Angstrom, c = 19.0706(13) Angstrom and Z = 6; 4, monoclinic in P21/c with a = 22.7650(15) Angstrom, b = 20.4656(10) Angstrom, c = 14.4770(9) Angstrom, P Y1 - 2004 UR - http://www3.interscience.wiley.com/cgi-bin/jissue/109594384 ER - TY - THES A1 - Hollnagel, Heli Miriam T1 - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridin : Bioaktivierung und DNA-Adduktbildung in V79-Zelllinien und verschiedenen Rattengeweben Y1 - 2004 ER - TY - JOUR A1 - Weiß, Norman T1 - 9. Forum Globale Fragen des Auswärtigen Amtes: „Fest entschlossen, unsere Kräfte zu vereinen ... " - die Vereinten Nationen als Motor globaler Strukturpolitik <2003, Berlin> / [Tagungsbericht] JF - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen N2 - Tagungsbericht: Auswärtiges Amt: „Fest entschlossen, unsere Kräfte zu vereinen . . . " - die Vereinten Nationenals Motor globaler Strukturpolitik <2003, Berlin> / (9. Forum Globale Fragen des Auswärtigen Amtes)am 11. und 12. Dezember 2003. Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-55725 SN - 1434-2820 VL - 9 IS - 1 SP - 106 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Denecke, Klaus-Dieter A1 - Wismath, Shelly T1 - A characterization of k-normal varieties N2 - Let v be a valuation of terms of type tau, assigning to each term t of type tau a value v(t) greater than or equal to 0. Let k greater than or equal to 1 be a natural number. An identity s approximate to t of type tau is called k- normal if either s = t or both s and t have value greater than or equal to k, and otherwise is called non-k-normal. A variety V of type tau is said to be k-normal if all its identities are k-normal, and non-k-normal otherwise. In the latter case, there is a unique smallest k-normal variety N-k(A) (V) to contain V , called the k-normalization of V. Inthe case k = 1, for the usual depth valuation of terms, these notions coincide with the well-known concepts of normal identity, normal variety, and normalization of a variety. I. Chajda has characterized the normalization of a variety by means of choice algebras. In this paper we generalize his results to a characterization of the k-normalization of a variety, using k-choice algebras. We also introduce the concept of a k-inflation algebra, and for the case that v is the usual depth valuation of terms, we prove that a variety V is k-normal iff it is closed under the formation of k- inflations, and that the k-normalization of V consists precisely of all homomorphic images of k-inflations of algebras in V Y1 - 2004 SN - 0002-5240 ER - TY - JOUR A1 - Delgrande, James Patrick A1 - Schaub, Torsten H. A1 - Tompits, Hans A1 - Wang, Kewen T1 - A classification and survey of preference handling approchaches in nonmonotonic reasoning N2 - In recent years, there has been a large amount of disparate work concerning the representation and reasoning with qualitative preferential information by means of approaches to nonmonotonic reasoning. Given the variety of underlying systems, assumptions, motivations, and intuitions, it is difficult to compare or relate one approach with another. Here, we present an overview and classification for approaches to dealing with preference. A set of criteria for classifying approaches is given, followed by a set of desiderata that an approach might be expected to satisfy. A comprehensive set of approaches is subsequently given and classified with respect to these sets of underlying principles Y1 - 2004 SN - 0824-7935 ER - TY - JOUR A1 - Klettke, Cornelia T1 - A colloquio con Andrea De Carlo Y1 - 2004 SN - 88-7667-182-X ER - TY - JOUR A1 - Klein, Eckart T1 - A comment on the issue of reservations to the provisions of the covenant representing (peremptory) rules of general international law Y1 - 2004 SN - 90-04- 14064-6 ER - TY - JOUR A1 - Sarsakov, Vladimir A1 - Schaub, Torsten H. A1 - Tompits, Hans A1 - Woltran, Stefan T1 - A compiler for nested logic programming Y1 - 2004 SN - 3-540- 20721-x ER - TY - JOUR A1 - Schurr, Frank Martin A1 - Dean, W. R. J. A1 - Milton, Sue J. A1 - Jeltsch, Florian T1 - A conceptual model linking demography of the shrub species Grewia flava to the dynamics of Kalahari savannas N2 - Environmental heterogeneity is a major determinant of plant population dynamics. In semi-arid Kalahari savannas, heterogeneity is created by savanna structure, i.e. by the spatial arrangement and temporal dynamics of woody plant and open grassland microsites. We formulate a conceptual model describing the effects of savanna dynamics on the population dynamics of the animal-dispersed shrub Grewia flava. From empirical results we derive model rules describing effects of savanna structure on several processes in Grewia's life cycle. By formulating the model, we summarise existing information on Grewia demography and identify gaps in this knowledge. Despite a number of such gaps, the model can be used to make certain quantitative predictions. As an example, we apply the model to investigate the role of seed dispersal in Grewia encroachment on rangelands. Model results show that cattle promote encroachment by depositing substantial numbers of seeds in open areas, where Grewia is otherwise dispersal-limited. Finally, we draw some general conclusions about Grewia's life history and population dynamics. Under natural conditions, concentrated seed deposition under woody plants appears to be a key process causing the observed association between Grewia and other woody plants. Furthermore, low rates of recruitment and high adult survival result in slow-motion dynamics of Grewia populations. As a consequence, Grewia populations interact with savanna dynamics on long temporal and short to intermediate spatial scales. Y1 - 2004 ER - TY - BOOK A1 - Gauthier, P. M. A1 - Tarkhanov, Nikolai Nikolaevich T1 - A covering proberty of the Riemann zeta-funktion T3 - Preprint / Universität Potsdam, Institut für Mathematik, Arbeitsgruppe Partiell Y1 - 2004 SN - 1437-739X PB - Univ. CY - Potsdam ER - TY - JOUR A1 - Ziehe, Andreas A1 - Laskov, Pavel A1 - Nolte, G A1 - Müller, Klaus-Robert T1 - A fast algorithm for joint diagonalization with non-orthogonal transformations and its application to blind source separation N2 - A new efficient algorithm is presented for joint diagonalization of several matrices. The algorithm is based on the Frobenius-norm formulation of the joint diagonalization problem, and addresses diagonalization with a general, non- orthogonal transformation. The iterative scheme of the algorithm is based on a multiplicative update which ensures the invertibility of the diagonalizer. The algorithm's efficiency stems from the special approximation of the cost function resulting in a sparse, block-diagonal Hessian to be used in the computation of the quasi-Newton update step. Extensive numerical simulations illustrate the performance of the algorithm and provide a comparison to other leading diagonalization methods. The results of such comparison demonstrate that the proposed algorithm is a viable alternative to existing state-of-the-art joint diagonalization algorithms. The practical use of our algorithm is shown for blind source separation problems Y1 - 2004 ER - TY - JOUR A1 - Pena, M. A1 - Hamann, Wolf-Rainer A1 - Ruiz, M. T. A1 - Peimbert, A. A1 - Peimbert, M. T1 - A high resolution spectroscopic study of the extraordinary planetary nebula LMC-N66 N2 - The planetary nebula N66 in the Large Magellanic Cloud is an extraordinary object, as it is the only confirmed PN where the central star is a Wolf-Rayet star of the nitrogen sequence, i.e. of type [WN]. Moreover, the star showed a dramatic brightness outburst in 1993-1994. In a previous paper (Hamann et al. 2003) we analyzed the changing stellar spectra and found evidence that the central star is most likely a binary system where a white dwarf presently accretes matter from a non-degenerate companion at a high rate. Thus the object is a candidate for a future type Ia supernova in our cosmic neighborhood. In the present paper we analyze the morphology and kinematics of the nebula, using images and high-resolution spectra obtained with the Hubble Space Telescope (HST) and the Very Large Telescope (ESO-VLT). The object presents a complex multipolar structure, dominated by very bright lobes located at both sides of the central star and separated by a narrow waist. In addition there is a pair of very extended and twisted loops, also pointing in opposite directions; their symmetry axis and collimation angle differs from those of the bright lobes. High resolution spectroscopy reveals two main velocity components, "approaching" material at an average heliocentric radial velocity Of V-rad = 248 30 km s(-1) and similarly bright "receding" material at V-rad = 331 +/- 25 km s(-1). A systemic velocity of about 300 km s(-1) is derived. Opposite lobes and loops possess opposite velocities. Furthermore there are knots and filaments of complex structure and kinematics. Close to the central star, nebular gas is found, receding at very high velocity (125 km s(-1) relative to the system). The morphology and kinematics of LMC-N66 can be explained as the result of episodic bipolar ejections with changing axis. The bipolar structures could have been produced by collimated streams ejected from a precessing central source. We suggest that the precession could have been produced by an external torque, possibly due to a binary companion. Young, fast-moving nebular knots close to the star appear slightly He- and N-richer than the main body of the nebula, but are still hydrogen-rich in contrast to the helium-dominated atmosphere of the [WN]- type central star. In the binary scenario, this nebular matter must have been accreted from the non-degenerate companion and re-ejected before it was fully burnt Y1 - 2004 ER - TY - JOUR A1 - Kühnel, Dana A1 - Steinberg, Pablo A1 - Scholtka, Bettina T1 - A human-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) can induce precancerous lesions in rat intestine after 6 months of exposure Y1 - 2004 SN - 0028-1298 ER - TY - JOUR A1 - Kress, H. A1 - Jarrin, A. A1 - Thuroff, E. A1 - Saunders, R. A1 - Weise, C. A1 - Schmidt am Busch, Marcel A1 - Knapp, E. W. A1 - Wedde, M. A1 - Vilcinskas, Andreas T1 - A Kunitz type protease inhibitor related protein is synthesized in Drosophila prepupal salivary glands and released into the moulting fluid during pupation N2 - From the Drosophila virilis late puff region 31C, we microcloned two neighbouring genes, Kil-1 and Kil-2, that encode putative Kunitz serine protease inhibitor like proteins. The Kil-1 gene is expressed exclusively in prepupal salivary glands. Using a size mutant of the KIL-1 protein and MALDI-TOF analysis, we demonstrate that during pupation this protein is released from the prepupal salivary glands into the pupation fluid covering the surface of the pupa. 3-D- structure predictions are consistent with the known crystal structure of the human Kunitz type protease inhibitor 2KNT. This is the first experimental proof for the extra-corporal presence of a distinct Drosophila prepupal salivary gland protein. Possible functions of KIL-1 in the context of the control of proteolytic activities in the pupation fluid are discussed. (C) 2004 Elsevier Ltd. All rights reserved Y1 - 2004 SN - 0965-1748 ER - TY - JOUR A1 - Pracht, M. A1 - Timmerman, Martin Jan T1 - A late Namurian (318 Ma) 40Ar-39Ar age for kaersutite megacrysts from the syn-tectonic Black Ball Head diatreme: implications for the onset of Variscan deformation in SW Ireland BT - Ein spätes Namurian (318 m.y.) Alter 40Ar/39Ar für kaersutitemegacrysts vom schwarzen Kugelkopfdiatreme: eine Altersgrenze für die Deformation Variscan im Südwesten Irland Y1 - 2004 SN - 0790-1763 ER - TY - JOUR A1 - Kietzke, Thomas A1 - Neher, Dieter A1 - Kumke, Michael Uwe A1 - Montenegro, Rivelino V. D. A1 - Landfester, Katharina A1 - Scherf, Ullrich T1 - A nanoparticle approach to control the phase separation in polyfluorene photovoltaic devices N2 - Polymer solar cell devices with nanostructured blend layers have been fabricated using single- and dual- component polymer nanospheres. Starting from an electron-donating and an electron-accepting polyfluorene derivative, PFB and F8BT, dissolved in suitable organic solvents, dispersions of solid particles with mean diameters of ca. 50 nm, containing either the pure polymer components or a mixture of PFB and F8BT in each particle, were prepared with the miniemulsion process. Photovoltaic devices based on these particles have been studied with respect to the correlation between external quantum efficiency and layer composition. It is shown that the properties of devices containing a blend of single-component PFB and F8BT particles differ significantly from those of solar cells based on blend particles, even for the same layer composition. Various factors determining the quantum efficiency in both kinds of devices are identified and discussed, taking into account the spectroscopic properties of the particles. An external quantum efficiency of ca. 4% is measured for a device made from polymer blend nanoparticles containing PFB:F8BT at a weight ratio of 1:2 in each individual nanosphere. This is among the highest values reported so far for photovoltaic cells using this material combination Y1 - 2004 ER - TY - JOUR A1 - Kummerow, J. A1 - Kind, Rainer A1 - Oncken, Onno A1 - Giese, Peter A1 - Ryberg, Trond A1 - Wylegalla, Kurt A1 - Scherbaum, Frank T1 - A natural and controlled source seismic profile through the Eastern Alps : TRANSALP N2 - The combined passive and active seismic TRANSALP experiment produced an unprecedented high-resolution crustal image of the Eastern Alps between Munich and Venice. The European and Adriatic Mohos (EM and AM, respectively) are clearly imaged with different seismic techniques: near-vertical incidence reflections and receiver functions (RFs). The European Moho dips gently southward from 35 km beneath the northern foreland to a maximum depth of 55 km beneath the central part of the Eastern Alps, whereas the Adriatic Moho is imaged primarily by receiver functions at a relatively constant depth of about 40 km. In both data sets, we have also detected first-order Alpine shear zones, such as the Helvetic detachment, Inntal fault and SubTauern ramp in the north. Apart from the Valsugana thrust, receiver functions in the southern part of the Eastern Alps have also observed a north dipping interface, which may penetrate the entire Adriatic crust [Adriatic Crust Interface (ACI)]. Deep crustal seismicity may be related to the ACI. We interpret the ACI as the currently active retroshear zone in the doubly vergent Alpine collisional belt. (C) 2004 Elsevier B.V. All rights reserved Y1 - 2004 ER - TY - JOUR A1 - Tischendorf, Gerhard A1 - Rieder, M. A1 - Förster, Hans-Jürgen A1 - Gottesmann, Bärbel A1 - Guidotti, C. V. T1 - A new graphical presentation and subdivision of potassium micas N2 - A system based on variation of the octahedrally coordinated cations is proposed for graphical presentation and subdivision of tri- and dioctahedral K micas, which makes use of elemental differences (in a.p.f.u.): (Mg - Li) [= mgli] and (Fe-tot + Mn + Ti - Al-VI) [= feal]. All common true tri- and dioctahedral K micas are shown in a single polygon outlined by seven main compositional points forming its vertices. Sequentially clockwise, starting from Mg-3 (phlogopite), these points are: Mg2.5Al0.5, Al(2.167)square(0.833), Al1.75Li1.25, Li2Al (polylithionite), Fe22+Li, and Fe-3(2+) (annite). Trilithionite (Li1.5Al1.5), Li1.5Fe2+Al0.5, Fe22+Mg, and Mg2Fe2+ are also located on the perimeter of the polygon. IMA-siderophyllite (Fe22+Al) and muscovite (Al(2)square) plot inside. The classification conforms with the IMA-approved mica nomenclature and differentiates among the following mica species according to their position in a diagram consisting of nigh and feal axes plotted orthogonally; trioctahedral: phlogopite, biotite, siderophyllite, annite, zinnwaldite, lepidolite and tainiolite: dioctahedral: muscovite, phengite and celadonite. Potassium micas with [Si] <2.5 a.p.f.u. including IMA-siderophyllite, KFe22+AlAl2Si2O10(OH)(2), and IMA-eastonite, KMg2AlAl2Si2O10(OH)(2) seem not to form in nature. The proposed subdivision has several advantages. All common true, trioctahedral and dioctahedral K micas, whether Li-bearing or Li-free, are shown within one diagram, which is easy to use and gives every mica composition an unambiguously defined name. Mica analyses with Fe2+, Fe3+, Fe2+ + Fe3+, or Fe-tot can be considered, which is particularly Valuable for microprobe analyses. It facilitates easy reconstruction of evolutionary pathways of mica compositions during crystallization, a feature having key importance in petrologically oriented research. Equally important, the subdivision has great potential for understanding many of the crystal-chemistry features of the K micas. In turn this may allow one to recognize and discriminate the extent to which crystal chemistry or bulk composition controls the occurrence of some seemingly possible or hypothetical K mica Y1 - 2004 SN - 0026-461X ER - TY - JOUR A1 - Graubaum, Hans-Joachim A1 - Luder, W. A1 - Zunft, Hans-Joachim Franz T1 - A new isolated soy protein with high levels of nondenaturated protein shows twice the cholesterol-lowering effect of a commercial isolated soy protein Y1 - 2004 SN - 0022-3166 ER - TY - JOUR A1 - Haußig, Hans-Michael T1 - A Religionïs Self-Conception of "Reliogion" : the case of judaism and islam Y1 - 2004 SN - 0-8130-2700-4 ER - TY - JOUR A1 - Goessel, Michael A1 - Chakrabarty, Krishnendu A1 - Ocheretnij, V. A1 - Leininger, Andreas T1 - A signature analysis technique for the identification of failing vectors with application to Scan-BIST N2 - We present a new technique for uniquely identifying a single failing vector in an interval of test vectors. This technique is applicable to combinational circuits and for scan-BIST in sequential circuits with multiple scan chains. The proposed method relies on the linearity properties of the MISR and on the use of two test sequences, which are both applied to the circuit under test. The second test sequence is derived from the first in a straightforward manner and the same test pattern source is used for both test sequences. If an interval contains only a single failing vector, the algebraic analysis is guaranteed to identify it. We also show analytically that if an interval contains two failing vectors, the probability that this case is interpreted as one failing vector is very low. We present experimental results for the ISCAS benchmark circuits to demonstrate the use of the proposed method for identifying failing test vectors Y1 - 2004 SN - 0923-8174 ER - TY - RPRT A1 - Wagner, Wolfgang T1 - A simulation of segregation in cities and its application for the analysis of rent control N2 - Social segregation in cities takes place where different household groups exist and when, according to Schelling, their location choice either minimizes the number of differing households in their neighborhood or maximizes their own group. In this contribution an evolutionary simulation based on a monocentric city model with externalities among households is used to discuss the spatial segregation patterns of four groups. The resulting complex spatial patterns can be shown as graphic animations. They can be applied as initial situation for the analysis of the effects a rent control has on segregation. T3 - Volkswirtschaftliche Diskussionsbeiträge - 71 Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-14177 ER - TY - JOUR A1 - Beissenhirtz, Moritz Karl A1 - Scheller, Frieder W. A1 - Lisdat, Fred T1 - A superoxide sensor based on a multilayer cytochrome c electrode N2 - A novel multilayer cytochrome c electrode for the quantification of superoxide radical concentrations is introduced. The electrode consists of alternating layers of cytochrome c and poly(aniline(sulfonic acid)) on a gold wire electrode. The formation of multilayer structures was proven by SPR experiments. Assemblies with 2-15 protein layers showed electrochemical communication with the gold electrode. For every additional layer, a substantial increase in electrochemically active cytochrome c (cyt. c) was found. For electrodes of more than 10 layers, the increase was more than 1 order of magnitude as compared to monolayer electrode systems. Thermodynamic and kinetic parameters of the electrodes were characterized. The mechanism of electron transfer within the multilayer assembly was studied, with results suggesting a protein-protein electron-transfer model. Electrodes of 2-15 layers were applied to the in vitro quantification of enzymatically generated superoxide, showing superior sensitivity as compared to a monolayer-based sensor. An electrode with 6 cyt. c/PASA layers showed the highest sensitivity of the systems studied, giving an increase in sensitivity of half an order of magnitude versus the that of the monolayer electrode. The stability of the system was optimized using thermal treatment, resulting in no loss in sensor signal or protein loading after 10 successive measurements or 2 days of storage Y1 - 2004 SN - 0003-2700 ER - TY - JOUR A1 - Hamann, Wolf-Rainer A1 - Gräfener, Götz T1 - A temperature correction method for expanding atmospheres Y1 - 2004 ER - TY - JOUR A1 - Gibbs, Moreland D. A1 - Reeves, Rosalind A. A1 - Sunna, Anwar A1 - Bergquist, Peter L. T1 - A yeast intron as a translational terminator in a plasmid shuttle vector N2 - Plasmid shuttle vectors that contain both prokaryotic (Escherichia coli) and eukaryotic origins of replication are routinely used in molecular biology since E coli is generally the organism of choice for manipulation of recombinant DNA. Initial transformation of the shuttle vector into E coli allows production of microgram quantities of DNA suitable for transformation of low-transformationefficiency hosts. A shuttle/expression vector for the yeast Kluyveromyces lactis, pCWK1, allows recombinant protein fused to the killer toxin signal sequence to be secreted to the medium. The heterologous genes are transcribed under the control of the K lactis LAC4 promoter, which is tightly regulated in K lactis. However, in E coli the LAC4 promoter functions constitutively, and as a result, uncontrolled transcription and translation of genes that are toxic in E coli can result in cell death, and subsequent failure to recover intact E. coli transformants. We have constructed and tested a modified shuttle vector that contains a K lactis ribosomal intron that acts as a translational terminator in E coli, preventing or reducing the expression of recombinant proteins and avoiding toxicity. When transcribed in K lactis, the intron is spliced from the mRNA allowing the translation of intact full- length, active recombinant gene product. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved Y1 - 2004 SN - 1567-1356 ER - TY - JOUR A1 - Kleinpeter, Erich A1 - Klod, Sabrina T1 - Ab initio calculation of the anisotropic/ring current effects of amino acid residues to locate the position of substrates in the binding site of enzymes N2 - The ring current effects of aromatic moieties and the anisotropic effects of the C=O and C-X (X = C, N, S) bonds and of the NH=C(NH2)-NH- moiety in the side chains of amino acid residues of proteins were ab initio calculated based on nuclear independent chemical shieldings as employed by P.v.R. Schleyer. Hereby, quantitative information about the spatial extension, sign and scope of the corresponding ring current/anisotropic effects was obtained and they were visualized as iso-chemical-shielding-surfaces. Examining this quantitative information compared with experimental NMR chemical shifts, the role of the corresponding amino acid residues in binding substrates in the binding site of enzymes was studied. (C) 2004 Elsevier B.V. All rights reserved Y1 - 2004 ER - TY - JOUR A1 - Koch, Andreas A1 - Mikhova, Bozhana A1 - Kleinpeter, Erich T1 - Ab initio MP2/GIAO/NBO study of the delta-syn-axial effect in C-13 NMR spectroscopy N2 - The C-13 chemical shifts of 20 rigid bicyclic compounds have been calculated with ab initio HF and MP2 methods. The calculations showed very good reproducibility of the experimental values. The molecular orbital interactions in the rigid, nearly planar delta-syn-axial fragments in the isomeric groups of norbornane derivatives 1.x-4.x were studied in detail and were employed to explain the deshielding delta-syn-axial effect in C-13 NMR spectroscopy. (C) 2004 Elsevier B.V. All rights reserved Y1 - 2004 SN - 0022-2860 ER - TY - BOOK A1 - Knippschild, Silke T1 - Abajo el tirano ! Destrucción de síbolos imperiales como representación del cambio de poder Y1 - 2004 SN - 84-8021-491-0 ER - TY - JOUR A1 - Angelow, Jürgen T1 - Accomplices with reservations : German diplomats and the preparation of the Polish campaign of September 1939 N2 - This paper examines the role of the conservative foreign policy establishment in the decision-making process leading to the Nazi invasion of Poland in September 1939. Post-war statements by German diplomats portrayed the conservative elite as reluctant participants in Hitler's drive to war. However, an examination of the foreign policy views of German conservatives reveals a significant degree of convergence with Nazi goals in their desire to revise Germany's post-Versailles borders with Poland. In order to understand the role of the German diplomatic elite, it is also necessary to understand the degree to which foreign policy was subject to the same "polycracy" of decision-making instances that characterised the structure of the "Third Reich" in general. While Hitler had relied on the conservative elites, including the Foreign Ministry and the military, their influence on decision-making was waning by 1938-1939 Y1 - 2004 ER - TY - JOUR A1 - Schweigert, Florian J. A1 - Raila, Jens A1 - Sehouli, Jalid A1 - Büscher, Ulrich T1 - Accumulation of Selected Carotenoids, alpha-tocopherol and Retinol in Human Ovarian Carcinoma Ascitic Fluid N2 - Background: Patients with severe forms of cancer are reported to have reduced concentrations of micronutrients in plasma due to the chronic reduction of food intake and an increased metabolism of these components. The purpose of this study was to evaluate if an accumulation of carotenoids, alpha-tocopherol and retinol in malignant ascitic fluid in women with ovarian cancer might contribute to a loss of these components from plasma. Methods: Blood and ascitic fluid samples obtained from 21 women with ovarian carcinomas and 17 healthy controls were analyzed for retinol, retinol- binding protein (RBP), alpha-tocopherol and carotenoids. Results: Plasma concentrations of all micronutrients were lower in cancer patients compared to controls. Ascitic fluid concentration of all investigated components was comparable (73- 110%) to plasma. While the mean concentration of retinol in malignant ascites represented 73% of that in plasma, the concentration of RBP was less than 10% resulting in an increased mean molar ratio of retinol to RBP from 1.18 to 10.5. Conclusions: The results suggest that lower plasma concentrations of micronutrients in women suffering from ovarian carcinoma are not only caused by a cachexia-induced decrease of food intake and a higher rate of metabolic utilization, but also by a substantial yet not considered transfer from plasma into ascitic fluid possibly associated with plasma lipoproteins. This raises questions with regard to the protective function of these plasma components in ascitic fluid, the consequences of paracentesis on an additional supplementation and finally the possibility to use one or a combination of these components as an additional marker to discriminate between benign and malignant ascites. Copyright (C) 2004 S. Karger AG, Basel Y1 - 2004 SN - 1421-9697 ER - TY - JOUR A1 - Domahs, Frank A1 - Lochy, A. A1 - Eibl, G. A1 - Delazer, M. T1 - Adding colour to multiplication: Rehabilitation of arithmetic fact retrieval in a case of traumatic brain injury N2 - This study describes ME, a patient in the chronic stage after a traumatic brain injury. During an extensive training programme ME tried to regain automaticity in the retrieval of simple multiplication facts. He succeeded in substantially decreasing response latencies in multiplication, reducing the handicap at his job. This improvement generalised to a non-trained operand order, to non-trained problems, and to a non-trained output modality. Moreover, these effects were maintained over at least four months. Interestingly, however, ME's training effects were operation specific: No significant improvement occurred in addition, subtraction, or division. As coloured presentation of multiplication problems proved to be a valuable cue in facilitating the patient's performance, this might turn out to be a useful tool in the rehabilitation of fact retrieval in general Y1 - 2004 SN - 0960-2011 ER - TY - BOOK ED - Mendes, Alexanda Navas ED - Vazquez, Graciela T1 - Adieu plus : comprension auditiva y visual de clases magistrales ; 14 CD-ROM T3 - Arqueología 02 Y1 - 2004 SN - 3-935024-93-2 VL - 2 PB - Univ.-Verl. CY - Potsdam ER - TY - JOUR A1 - Kuhn, Hans-Peter T1 - Adolescent voting for right-wing extremist parties and readiness to use violence in political action : parent and peer contexts N2 - Almost all shapes of adolescent risky and deviant behaviour take place in the context of peer-relations. The present study examined the role of parents and peer-relations with respect to two indicators of deviant political development. In the fall 1998, directly after the German parliamentary elections, 1309 East German adolescents were asked about their voting for a right-wing extremist party and their readiness to use violence in political action. Friend's voting was a strong predictor of individual voting for a right-wing extremist party, particularly when the friend was the best friend with a reciprocal nomination, and when the friends frequently communicated about political themes. In addition, voting behaviour and willingness to use violence were associated with membership in peer groups who met frequently. Finally, the violence disposed adolescents spent more of their spare time with peers and less with their parents. Similarities of our results with the findings of research on deviant behaviour in non-political areas support the idea that deviant political behaviour could be an expression of a problematic life situation. (C) 2004 Published by Elsevier Ltd. on behalf of The Association for Professionals in Services for Adolescents Y1 - 2004 ER - TY - JOUR A1 - Unterhuber, Angelika A1 - Povazay, B. A1 - Bizheva, K. A1 - Hermann, B. A1 - Sattmann, Harald A1 - Stingl, A. A1 - Le, Trang A1 - Seefeldt, Michael A1 - Menzel, Ralf A1 - Preusser, Matthias A1 - Budka, Herbert A1 - Schubert, Christian A1 - Reitsamer, H. A1 - Ahnelt, Peter Kurt A1 - Morgan, J. E. T1 - Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomography N2 - Novel ultra-broad bandwidth light sources enabling unprecedented sub-2 pm axial resolution over the 400 nm-1700 nm wavelength range have been developed and evaluated with respect to their feasibility for clinical ultrahigh resolution optical coherence tomography (UHR OCT) applications. The state-of-the-art light sources described here include a compact Kerr lens mode locked Ti:sapphire laser (lambda(c) = 785 nm, Deltalambda = 260 nm, P-out = 50 mW) and different nonlinear fibre-based light sources with spectral bandwidths (at full width at half maximum) up to 350 nm at lambda(c) = 1130 nm and 470 nm at lambda(c) = 1375 run. In vitro UHR OCT imaging is demonstrated at multiple wavelengths in human cancer cells, animal ganglion cells as well as in neuropathologic and ophthalmic biopsies in order to compare and optimize UHR OCT image contrast, resolution and penetration depth Y1 - 2004 SN - 0031-9155 ER - TY - JOUR A1 - Weske, Mathias A1 - van der Aalst, Wil M. P. A1 - Verbeek, H. M. W. T1 - Advances in business process management Y1 - 2004 SN - 0169-023X ER - TY - THES A1 - Engels, Eva T1 - Adverb placement : an optimality theoretic approach T1 - Adverbstellung : ein optimalitätstheoretischer Ansatz N2 - Adverb positioning is guided by syntactic, semantic, and pragmatic considerations and is subject to cross-linguistic as well as language-specific variation. The goal of the thesis is to identify the factors that determine adverb placement in general (Part I) as well as in constructions in which the adverb's sister constituent is deprived of its phonetic material by movement or ellipsis (gap constructions, Part II) and to provide an Optimality Theoretic approach to the contrasts in the effects of these factors on the distribution of adverbs in English, French, and German. In Optimality Theory (Prince & Smolensky 1993), grammaticality is defined as optimal satisfaction of a hierarchy of violable constraints: for a given input, a set of output candidates are produced out of which that candidate is selected as grammatical output which optimally satisfies the constraint hierarchy. Since grammaticality crucially relies on the hierarchic relations of the constraints, cross-linguistic variation can be traced back to differences in the language-specific constraint rankings. Part I shows how diverse phenomena of adverb placement can be captured by corresponding constraints and their relative rankings: - contrasts in the linearization of adverbs and verbs/auxiliaries in English and French - verb placement in German and the filling of the prefield position - placement of focus-sensitive adverbs - fronting of topical arguments and adverbs Part II extends the analysis to a particular phenomenon of adverb positioning: the avoidance of adverb attachment to a phonetically empty constituent (gap). English and French are similar in that the acceptability of pre-gap adverb placement depends on the type of adverb, its scope, and the syntactic construction (English: wh-movement vs. topicalization / VP Fronting / VP Ellipsis, inverted vs. non-inverted clauses; French: CLLD vs. Cleft, simple vs. periphrastic tense). Yet, the two languages differ in which strategies a specific type of adverb may pursue to escape placement in front of a certain type of gap. In contrast to English and French, placement of an adverb in front of a gap never gives rise to ungrammaticality in German. Rather, word ordering has to obey the syntactic, semantic, and pragmatic principles discussed in Part I; whether or not it results in adverb attachment to a phonetically empty constituent seems to be irrelevant: though constraints are active in every language, the emergence of a visible effect of their requirements in a given language depends on their relative ranking. The complex interaction of the diverse factors as well as their divergent effects on adverb placement in the various languages are accounted for by the universal constraints and their language-specific hierarchic relations in the OT framework. N2 - Die Positionierung von Adverbien wird von syntaktischen, semantischen und pragmatischen Erwägungen geleitet; sie unterliegt der zwischen-sprachlichen als auch der einzel-sprachlichen Variation. Ziel der Arbeit ist es, diejenigen Faktoren zu identifizieren, die ausschlaggebend sind für die Platzierung von Adverbien im allgemeinen (Teil I) sowie in speziellen Konstruktionen, in denen die Schwesterkonstituente eines Adverbs aufgrund von Bewegung oder Ellipse kein phonetisches Material enthält (Gap-Konstruktionen, Teil II). Des weiteren sollen die unterschiedlichen Ausprägungen dieser Faktoren in den distributionalen Mustern des Englischen, Französischen und Deutschen in einem optimalitätstheoretischen Rahmen erklärt werden. In der Optimalitätstheorie (Prince & Smolensky 1993) ist Grammatikalität als optimale Erfüllung einer Hierarchie von verletzbaren Constraints definiert: Für einen gegebenen Input wird eine Menge von Outputkandidaten bereitgestellt, aus der derjenige Kandidat als grammatischer Output gewählt wird, der die Constrainthierarchie am besten erfüllt. Da die hierarchischen Relationen der Constraints für die Ermittlung des grammatischen Outputs entscheidend sind, kann zwischen-sprachliche Variation auf Diskrepanzen in den einzel-sprachlichen Constrainthierarchien zurückgeführt werden. Der erste Teil der Arbeit zeigt, wie diverse Phänomene der Adverbstellung mit entsprechenden Constraints und ihren Anordnungen erfasst werden können: - Kontraste in der Linearisierung von Adverbien und Verben/Auxiliaren im Englischen und Französischen - Verbplatzierung im Deutschen und Vorfeldbesetzung - Platzierung von fokus-sensitiven Adverbien - Voranstellung von topikalen Argumenten und Adverbien Der zweite Teil der Arbeit spezialisiert sich auf ein bestimmtes Phänomen der Adverbpositionierung: das Meiden der Adverb-Adjunktion an eine phonetisch leere Konstituente (Gap). Englisch und Französisch ähneln sich insofern, als die Akzeptabilität der Adverbpositionierung vor einem Gap beeinflusst wird vom Typ des Adverbs, seinem Skopus und der syntaktischen Konstruktion (Englisch: wh-Bewegung vs. Topikalisierung / VP Voranstellung / VP Ellipse, invertierte vs. nicht-invertierte Sätze; Französisch: CLLD vs. Cleft, einfache vs. periphrastische Tempusformen). Die beiden Sprachen unterscheiden sich jedoch darin, ob - und falls ja - welche Strategie ein bestimmter Typ von Adverb verfolgen kann, um der Stellung vor einem speziellen Gap zu entkommen. Im Gegensatz zum Englischen und Französischen führt die Stellung eines Adverbs vor einem Gap im Deutschen nie zu Ungrammatikalität. Vielmehr hat die Adverbpositionierung den in Teil I diskutierten syntaktischen, semantischen und pragmatischen Prinzipien zu gehorchen; ob dies in der Adjunktion eines Adverbs an eine phonetisch leere Konstituente resultiert, scheint dabei irrelevant: Obwohl Constraints in jeder Sprache aktiv sind, hängt es von ihrer relativen Anordnung zueinander ab, ob sie einen sichtbaren Effekt in einer gegebenen Sprache hinterlassen. Die komplexe Interaktion der diversen Faktoren sowie deren divergierende Ausprägung auf die Adverbplatzierung in den unterschiedlichen Sprachen können in der Optimalitätstheorie auf die universalen Constraints und deren einzel-sprachliche Anordnung zurückgeführt werden. KW - Adverb KW - Syntax KW - Lesart KW - Variation KW - Informationsstruktur KW - Optimalitätstheorie KW - syntaktische Lücken KW - adverb KW - syntax KW - reading KW - variation KW - information structure KW - optimality theory KW - syntactic gaps Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-2453 ER - TY - JOUR A1 - Böckmann, Christine A1 - Wandinger, Ulla A1 - Ansmann, Albert A1 - Bösenberg, Jens A1 - Amiridis, Vassilis A1 - Boselli, Antonella A1 - Delaval, Arnaud A1 - De Tomasi, Ferdinando de A1 - Frioud, Max A1 - Grigorov, Ivan Videnov A1 - Hagard, Arne A1 - Horvat, Matej A1 - Iarlori, Marco A1 - Komguem, Leonce A1 - Kreipl, Stephan A1 - Larchevque, Gilles A1 - Matthias, Volker A1 - Papayannis, Alexandros A1 - Pappalardo, GGelsomina A1 - Rocadenbosch, Francesc A1 - Rodrigues, Jose António A1 - Schneider, Johannes A1 - Shcherbakov, Valery A1 - Wiegner, Matthias T1 - Aerosol lidar intercomparison in the framework of the EARLINET project : 2. Aerosol backscatter algorithms N2 - An intercomparison of aerosol backscatter lidar algorithms was performed in 2001 within the framework of the European Aerosol Research Lidar Network to Establish an Aerosol Climatology (EARLINET). The objective of this research was to test the correctness of the algorithms and the influence of the lidar ratio used by the various lidar teams involved in the EARLINET for calculation of backscatter-coefficient profiles from the lidar signals. The exercise consisted of processing synthetic lidar signals of various degrees of difficulty. One of these profiles contained height- dependent lidar ratios to test the vertical influence of those profiles on the various retrieval algorithms. Furthermore, a realistic incomplete overlap of laser beam and receiver field of view was introduced to remind the teams to take great care in the nearest range to the lidar. The intercomparison was performed in three stages with increasing knowledge on the input parameters. First, only the lidar signals were distributed; this is the most realistic stage. Afterward the lidar ratio profiles and the reference values at calibration height were provided. The unknown height- dependent lidar ratio had the largest influence on the retrieval, whereas the unknown reference value was of minor importance. These results show the necessity of making additional independent measurements, which can provide us with a suitable approximation of the lidar ratio. The final stage proves in general, that the data evaluation schemes of the different groups of lidar systems work well. (C) 2004 Optical Society of America Y1 - 2004 SN - 0003-6935 ER - TY - JOUR A1 - Uhlendorff, Harald T1 - After the wall: Parental attitudes to child rearing in East and West Germany N2 - In the years following German reunification, East and West German parents (282 mothers and 207 fathers) were interviewed about attitudes to the rearing of their 7- to 13-year-old children and about their social networks. Path analyses show that East German parents engage in more protective and less permissive parenting, and that East German fathers raise their children in a more traditional and authoritarian manner than their West German counterparts. In part, these differences can be attributed to the strong family orientation of East German parents (many and intensive kinship relations, few friends). Further analyses show that corollaries of the social upheavals in East Germany, namely closer cohesion of the immediate family and a decrease in the social support provided by the extrafamilial environment, are associated with protective attitudes to parenting and hence with the tendency to limit children's freedom of decision-making Y1 - 2004 ER - TY - BOOK ED - Drexler, Peter ED - Schnoor, Rainer T1 - Against the grain = Gegen den Strich gelesen : studies in english and american literature and literary theory ; Festschrift für Wolfgang Wicht T3 - Potsdamer Beiträge zur Kultur- und Sozialgeschichte Y1 - 2004 SN - 3-89626-499-0 VL - 3 PB - Trafo-Verl. CY - Berlin ER - TY - JOUR A1 - Laschewsky, André A1 - Mallwitz, Frank A1 - Baussard, Jean-Francois A1 - Cochin, Didier A1 - Fischer, Peter A1 - Habib-Jiwan, Jean-Louis A1 - Wischerhoff, Erik T1 - Aggregation phenomena in polyelectrolyte multilayers made from polyelectrolytes bearing bulky functional, hydrophobic fragments N2 - The functionalization of polyelectrolyte multilayers often implies the use of bulky functional fragments, attached to a standard polyelectrolyte matrix. Despite of the high density of non-charged, often hydrophobic substituents, regular film growth by sequential adsorption proceeds easily when an appropriate polyelectrolyte counter ion is chosen. However, the functional fragments may cluster or aggregate. This complication is particularly evident when using chromophores and fluorophores as bulky pendant groups. Attention has to be paid to this phenomenon for the design of functional polyelectrolyte films, as aggregation may modify crucially the properties. The use of charged spacer groups does not necessarily suppress the aggregation of functional side groups. Still, clustering and aggregation depend on the detailed system employed, and are not obligatory. In the case of cationic poly(acrylamide)s labeled with naphthalene and pyrene fluorophores, for instance, the polymers form intramolecular hydrophobic associates in solution, as indicated by strong excimer formation. But the polymers can undergo a conformational rearrangement upon adsorption so that they are decoiled in the adsorbed films. Analogous observations are made for polyanions bearing mesogenic biphenyls fragments. In contrast, polycations functionalized with the dye coumarin 343 show little aggregation in solution, but a marked aggregation in the ESA films Y1 - 2004 ER - TY - JOUR A1 - Neuschäfer-Rube, Frank A1 - Hermosilla, Ricardo A1 - Kuna, Manuela A1 - Pathe-Neuschaefer-Rube, Andrea A1 - Püschel, Gerhard Paul T1 - Agonist-induced desensitization of rat prostaglandin EP3 receptor isoforms Y1 - 2004 SN - 0028-1298 ER - TY - JOUR A1 - Wanner, Manfred A1 - Anders, Kenneth A1 - Bischof, Ronny A1 - Brozio, Fritz A1 - Burkart, Bettina A1 - Prochnow, Annette A1 - Riedel, Heidi A1 - Schneider, Dieter A1 - Wiesener, Cornelia A1 - Zulka, Klaus Peter A1 - Zumkowski-Xylander, Helga A1 - Xylander, Willi E. R. T1 - Aktiver Truppenübungsplatz Oberlausitz Y1 - 2004 SN - 3-540-22449-1 ER - TY - BOOK A1 - Sändig, Brigitte T1 - Albert Camus : Autonomie und Solidarität Y1 - 2004 SN - 3-8260-2630-6 PB - Königshausen & Neumann CY - Würzburg ER - TY - JOUR A1 - Weiß, Norman T1 - Albrecht Weber: Menschenrechte, Texte und Fallpraxis / [rezensiert von] Norman Weiß JF - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen N2 - rezensiertes Werk: Weber, Albrecht: Menschenrechte, Texte und Fallpraxis. München : Sellier ; European Law Publishers GmbH. - 1.050 S. ISBN: 3-935808-05-4 Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-55822 SN - 1434-2820 VL - 9 IS - 2 SP - 214 EP - 215 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Franz, Norbert P. T1 - Alexander Newski : ein Propagandafilm? ; Feature im Bonusprogramm einer DVD Y1 - 2004 ER - TY - RPRT A1 - Schulze, Andreas T1 - Alternative Liberalisierungsansätze in Netzindustrien BT - Beitrag zum Workshop des Instituts für Wirtschaftsforschung Deregulierung in Deutschland Theoretische und empirische Analysen, Halle/Saale, 26.3.2004 N2 - Inhalt 1 Einführung und Grundlagen 1.1 Problemstellung und Vorgehensweise 1.2 Ordnungsökonomische Systematisierung 1.3 „Neue“ Besonderheitenlehre für Netzindustrien 2 Ansatzpunkte zur Liberalisierung in Netzindustrien 2.1 Liberalisierung durch Privatisierung 2.1.1 Interdependenz von Privatisierung und Marktöffnung 2.1.2 Privatisierungsstufen 2.2 Liberalisierung durch Deregulierung und Re-Regulierung 2.2.1 Abgrenzung des relevanten Marktes: Netzinfrastruktur versus Netzdienstleistungen 2.2.2 Lokalisierung und Kontrolle von Marktmacht bei Netzinfrastruktur 2.3 Modelle zur Gewährleistung eines diskriminierungsfreien Netzzugangs 2.3.1 Verhandelter Netzzugang mit Missbrauchsaufsicht im Sinne der Essential-Facilities-Doktrin 2.3.2 Staatliche Regulierung des Netzzugangs 2.4 Theorie der vertikalen (Des-)Integration 2.4.1 Allokativ-statische, wohlfahrtsökonomische Analyse vertikaler Integration 2.4.2 Institutionenökonomische Analyse vertikaler Integration 2.4.3 Dynamische, wettbewerbsökonomische Analyse vertikaler Integration 2.4.4 Konsequenz: Vertikale Desintegration 3 Institutionelle Ausgestaltung der Wettbewerbsaufsicht 3.1 Systematisierung der Träger und Kompetenzabgrenzung 3.2 Kriterien für eine effiziente Wettbewerbsaufsicht 4 Schlussfolgerungen und intersektoraler Vergleich des Liberalisierungsprozessesin Netzindustrien T3 - Volkswirtschaftliche Diskussionsbeiträge - 64 Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-14068 ER - TY - JOUR A1 - Jaeger, Gerhard T1 - Alternatives or presuppositions? a comparison of the background presupposition rule with alternative semantics Y1 - 2004 SN - 0301-4428 ER - TY - JOUR A1 - Simon, Theresia Maria T1 - Alternatives to strategic positioning of a university library N2 - In the past academic libraries in Germany have been successfully undertaking joint endeavors toward a social and political definition of the knowledge society by cooperatively developing ways to provide information and increasing the digital forms of metadata and media. In doing so, they have unintentionally created the basis for a competitive playing field in which the individual library must establish strategic positions for success if it is to maintain viability and ensure continuous flow of resources. This article develops a framework for discussing such alternative and potentially successful strategies from the point of view of a university library Y1 - 2004 SN - 0044-2380 ER - TY - JOUR A1 - Grözinger, Elvira T1 - Althaus, H. P., Chuzpe, Schmus & Tacheles : jidische Wortgeschichten; München, Beck, 2004 BT - Chuzpe, Schmus & Tacheles : jidische Wortgeschichten Y1 - 2004 ER - TY - JOUR A1 - Grözinger, Elvira T1 - Althaus, H. P., Kleines Lexikon deutscher Wörter Jidischer Herkunft; München, Beck, 2003 BT - Kleines Lexikon deutscher Wörter Jidischer Herkunft Y1 - 2004 ER - TY - JOUR A1 - Grözinger, Elvira T1 - Althaus, H. P., Mauscheln : ein Wort als Waffe; Berlin, de Gruyter, 2002 BT - Mauscheln : ein Wort als Waffe Y1 - 2004 ER - TY - JOUR A1 - Grözinger, Elvira T1 - Althaus, H. P., Zocker, Zoff & Zores : jiddische Wörter im Deutschen; München, Beck, 2002 BT - Zocker, Zoff & Zores : jiddische Wörter im Deutschen Y1 - 2004 ER - TY - JOUR A1 - Kohler, A. A1 - Ohrnberger, Matthias A1 - Scherbaum, Frank A1 - Stange, S. A1 - Kind, F. T1 - Ambient vibration measurements in the Southern Rhine Graben close to Basle N2 - This study presents results of ambient noise measurements from temporary single station and small-scale array deployments in the northeast of Basle. H/V spectral ratios were determined along various profiles crossing the eastern masterfault of the Rhine Rift Valley and the adjacent sedimentary rift fills. The fundamental H/V peak frequencies are decreasing along the profile towards the eastern direction being consistent with the dip of the tertiary sediments within the rift. Using existing empirical relationships between H/V frequency peaks and the depth of the dominant seismic contrast, derived on basis of the lambda/4-resonance hypothesis and a power law depth dependence of the S-wave velocity, we obtain thicknesses of the rift fill from about 155 m in the west to 280 in in the east. This is in agreement with previous studies. The array analysis of the ambient noise wavefield yielded a stable dispersion relation consistent with Rayleigh wave propagation velocities. We conclude that a significant amount of surface waves is contained in the observed wavefield. The computed ellipticity for fundamental mode Rayleigh waves for the velocity depth models used for the estimation of the sediment thicknesses is in agreement with the observed H/V spectra over a large frequency band Y1 - 2004 SN - 1593-5213 ER - TY - JOUR A1 - Rößler, Dirk A1 - Rumpker, Georg A1 - Krüger, Frank T1 - Ambiguous moment tensors and radiation patterns in anisotropic media with applications to the modeling of earthquake mechanisms in W-Bohemia N2 - Anisotropic material properties are usually neglected during inversions for source parameters of earthquakes. In general anisotropic media, however, moment tensors for pure-shear sources can exhibit significant non-double-couple components. Such effects may be erroneously interpreted as an indication for volumetric changes at the source. Here we investigate effects of anisotropy on seismic moment tensors and radiation patterns for pure-shear and tensile-type sources. Anisotropy can significantly influence the interpretation of the source mechanisms. For example, the orientation of the slip within the fault plane may affect the total seismic moment. Also, moment tensors due to pure- shear and tensile faulting can have similar characteristics depending on the orientation of the elastic tensor. Furthermore, the tensile nature of an earthquake can be obscured by near-source anisotropic properties. As an application, we consider effects of inhomogeneous anisotropic properties on the seismic moment tensor and the radiation patterns of a selected type of micro-earthquakes observed in W-Bohemia. The combined effects of near-source and along- path anisotropy cause characteristic amplitude distortions of the P, S1 and S2 waves. However, the modeling suggests that neither homogeneous nor inhomogeneous anisotropic properties alone can explain the observed large non-double-couple components. The results also indicate that a correct analysis of the source mechanism, in principle, is achievable by application of anisotropic moment tensor inversion Y1 - 2004 SN - 0039-3169 ER - TY - BOOK A1 - Donner, Reik Volker A1 - Cser, Adrienn A1 - Schwarz, Udo A1 - Otto, Andreas H. A1 - Feudel, Ulrike T1 - An approach to a process model of laser beam melt ablation using methods of linear and non-linear data analysis N2 - As a non-contact process laser beam melt ablation offers several advantages compared to conventional processing mechanisms. During ablation the surface of the workpiece is molten by the energy of a CO2-laser beam, this melt is then driven out by the impulse of an additional process gas. Although the idea behind laser beam melt ablation is rather simple, the process itself has a major limitation in practical applications: with increasing ablation rate surface quality of the workpiece processed declines rapidly. With different ablation rates different surface structures can be distinguished, which can be characterised by suitable surface parameters. The corresponding regimes of pattern formation are found in linear and non-linear statistical properties of the recorded process emissions as well. While the ablation rate can be represented in terms of the line-energy, this parameter does not provide sufficient information about the full behaviour of the system. The dynamics of the system is dominated by oscillations due to the laser cycle but includes some periodically driven non-linear processes as well. Upon the basis of the measured time series, a corresponding model is developed. The deeper understanding of the process can be used to develop strategies for a process control. Y1 - 2004 SN - 3-527-40430-9 ER - TY - JOUR A1 - Allefeld, Carsten A1 - Kurths, Jürgen T1 - An approach to multivariate phase synchronization analysis and its application to event-related potentials N2 - A method for the multivariate analysis of statistical phase synchronization phenomena in empirical data is presented. A first statistical approach is complemented by a stochastic dynamic model, to result in a data analysis algorithm which can in a specific sense be shown to be a generic multivariate statistical phase synchronization analysis. The method is applied to EEG data from a psychological experiment, obtaining results which indicate the relevance of this method in the context of cognitive science as well as in other fields Y1 - 2004 SN - 0218-1274 ER - TY - JOUR A1 - Scheich, Christoph A1 - Niesen, F. H. A1 - Seckler, Robert A1 - Bussow, K. T1 - An automated in vitro protein folding screen applied to a human dynactin subunit N2 - The preparation of proteins for structural and functional analysis using the Escherichia coli expression system is often hampered by the formation of insoluble intracellular protein aggregates (inclusion bodies). Transferring those proteins into their native states by in vitro protein folding requires screening for the best buffer conditions and suitable additives. However, it is difficult to assess the success of such a screen if no biological assay is available. We established a fully automated folding screen and a system to detect folded protein that is based on analytical hydrophobic interaction chromatography and tryptophan fluorescence spectroscopy. The system was evaluated with two model enzymes (carbonic anhydrase II and malate dehydrogenase), and was successfully applied to the folding of the p22 subunit of human dynactin, which is expressed in inclusion bodies in E. coli. The described screen allows for high-throughput folding analysis of inclusion body proteins for structural and functional analyses Y1 - 2004 SN - 0961-8368 ER - TY - JOUR A1 - Wilmking, M. A1 - Ibendorf, J. T1 - An early tree-line experiment by a wilderness advocate : Bob Marshall's legacy in the Brooks Range, Alaska Y1 - 2004 SN - 0004-0843 ER - TY - JOUR A1 - Lettau, Kristian A1 - Warsinke, Axel A1 - Laschewsky, André A1 - Mosbach, K. A1 - Yilmaz, E. A1 - Scheller, Frieder W. T1 - An esterolytic imprinted polymer prepared via a silica-supported transition state analogue N2 - In this work we describe a new preparation method for an esterolytic imprinted polymer with catalytic sites on the surface. A template was prepared by immobilizing a transition state analogue (phosphoramidic acid derivative) of an esterolytic reaction within porous silica particles. Polymerization within the pores was carried out using 4- vinylimidazole as a functional monomer and divinylbenzene as a cross-linker. The polymer was released by dissolution of the silica support with hydrofluoric acid and catalytic properties were studied by incubation with three different 4- nitrophenylesters and spectrophotometric determination of the released 4-nitrophenol. For 4-nitrophenyl acetate an activity of 211 nmol min(-1) mg(-1) and a K-m value of 2.2 mmol L-1 was obtained Y1 - 2004 ER - TY - GEN A1 - Roelly, Sylvie A1 - Dai Pra, Paolo T1 - An existence result for infinite-dimensional Brownian diffusions with non- regular and non Markovian drift N2 - We prove in this paper an existence result for infinite-dimensional stationary interactive Brownian diffusions. The interaction is supposed to be small in the norm ||.||∞ but otherwise is very general, being possibly non-regular and non-Markovian. Our method consists in using the characterization of such diffusions as space-time Gibbs fields so that we construct them by space-time cluster expansions in the small coupling parameter. KW - infinite-dimensional Brownian diffusion KW - space-time Gibbs field KW - cluster expansion Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-6684 ER - TY - JOUR A1 - Hanke, Timo T1 - An explicit example of a noncrossed product division algebra N2 - The paper presents an explicit example of a noncrossed product division algebra of index and exponent 8 over the field Q(s) (t). It is an iterated twisted function field in two variables D (x, sigma) (y, tau) over a quaternion division algebra D which is defined over the number field Q(root3, root-7). The automorphisms sigma and tau are computed by solving relative norm equations in extensions of number fields. The example is explicit in the sense that its structure constants are known. Moreover, it is pointed out that the same arguments also yield another example, this time over the field Q((s)) ((t)), given by an iterated twisted Laurent series ring D((x, sigma)) ((y, tau)) over the same quaternion division algebra D. (C) 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Y1 - 2004 SN - 0025-584X ER - TY - JOUR A1 - Schmidt, Robert W. A1 - Allen, S. W. A1 - Fabian, A. C. T1 - An improved approach to measuring H-0 using X-ray and SZ observations of galaxy clusters N2 - We present an improved method for predicting the Sunyaev-Zeldovich (SZ) effect in galaxy clusters from spatially resolved, spectroscopic X-ray data. Using the deprojected electron density and temperature profiles measured within a fraction of the virial radius, and assuming a Navarro-Frenk-White mass model, we show how the pressure profile of the X-ray gas can be extrapolated to large radii, allowing the Comptonization parameter profile for the cluster to be predicted precisely. We apply our method to Chandra observations of three X-ray-luminous, dynamically relaxed clusters with published SZ data: RX J1347.5-1145, Abell 1835 and Abell 478. Combining the predicted and observed SZ signals, we determine improved estimates for the Hubble constant from each cluster and obtain a weighted mean of H (0) = 69 +/- 8 km s(-1) Mpc(-1) for a cosmology with Omega(m) = 0.3 and Omega(Lambda) = 0.7. This result is in good agreement with independent findings from the Hubble Key Project and the combination of cosmic microwave background and galaxy cluster data Y1 - 2004 SN - 0035-8711 ER - TY - THES A1 - Himmel, Mirko T1 - Analyse von Protein-Protein-Wechselwirkungen und der in vivo Phosphorylierung des Sarkomerproteins Myomesin T1 - Analysis of Protein-Protein Interactions and in vivo Phosphorylation of the Sarcomeric Protein Myomesin N2 - Für ein tiefergehendes Verständnis von Entwicklung und Funktion der quergestreiften Muskulatur ist eine Betrachtung der am Aufbau der Myofibrillen, den kontraktilen Organellen, beteiligten Proteine essentiell. Die vorliegende Arbeit beschäftigt sich mit Myomesin, einem Protein der sarkomeren M-Bande. Zunächst wurde die cDNA des humanen Myomesins vollständig kloniert, sequenziert und nachfolgend die komplette Größe der aminoterminalen Kopfdomäne bestimmt. Es konnte gezeigt werden, daß Myomesin in vitro mit den Domänen 1 und 12 an Myosin bindet. Die muskelspezifische Isoform der Kreatinkinase bindet an die Domänen 7 und 8. Stimulations- und Inhibitionsexperimente belegen, daß Myomesin an Serin 618 in vivo durch die Proteinkinase A phosphoryliert wird und daß diese Phosphorylierung durch Aktivierung beta2-adrenerger Rezeptoren stimulierbar ist. In Muskelgewebeproben von Patienten, die an der Hypertrophen Kardiomyopathie, einer genetisch bedingten Herzmuskelkrankheit, erkrankt sind, konnte mit einem neu hergestellten phosphorylierungsabhängigen Antikörper eine Verminderung der Menge phosphorylierten Myomesins nachgewiesen werden. Mögliche Ursachen werden diskutiert. Myomesin bildet Dimere, wie durch hefegenetische und biochemische Experimente gezeigt werden konnte. Die Dimerisierung von Myomesin könnte eine zentrale Rolle für den Einbau der Myosinfilamente in die naszierende Myofibrille haben. Anhand der gewonnenen Daten wurde ein verbessertes Modell der zentralen M-Bande erstellt. N2 - A deep understanding of the development and function of the sarcomeric muscle depends on the careful study of proteins involved in the assembly of myofibrills, the contractile organelles in cross-striated muscle. This thesis deals with the sarcomeric M-band protein myomesin. First, the complete cDNA of human myomesin was cloned, sequenced, and subsequently the size of the aminoterminal head domain of myomesin was determined. Myomesin binds to myosin in vitro via domains 1 and 12. Musclespecific creatine kinase is binding to the domains 7 and 8 of myomesin. Stimulation and inhibition experiments revealed, that serin 618 in human myomesin is phosphorylated in vivo by protein kinase A and that this phosphorylation can be stimulated by activation of beta2-adrenergic receptors. In muscle tissue of patients showing symptoms of the hypertrophic cardiomyopathy, a cardiac disease caused by genetic defects, the amount of phosphorylated myomesin was lowered as detected by a phosphospecific antibody which was established new. Myomesin dimerizes as shown by yeast two hybrid and biochemical experiments. Myomesin dimerization could be a central point in myofibrillogenesis, when myosin filaments were incorporated in nascent myofibrills. Taking all the data together, an improved model of the central M-band was developed. KW - Proteine KW - Myofibrille KW - Sarkomer KW - Phosphorylierung KW - M-Bandenmodell KW - PKA KW - M-band model KW - PKA Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-5153 ER - TY - THES A1 - Schwonbeck, Susanne T1 - Analyse von Single Nucleotide Polymorphisms an Glas-Oberflächen N2 - Ziel der vorliegenden Arbeit war die Entwicklung einer SNP-Genotypisierungsmethode mit auf Mikroarrays immobilisierten PCR-Produkten. Für die Analyse wurde ein faseroptischer Affinitätssensor bzw. ein Durchfluss-Biochip-Scanner mit integrierter Fluoreszenzdetektion verwendet. An den immobilisierten Analyten (PCR-Produkten) wurde eine Fluoreszenzoligonukleotidsonde hybridisiert und anschließend die Dissoziation der Sonde im Fluss verfolgt. Die Diskriminierung von Wildtyp- und Mutanten-DNA erfolgte durch die kinetische Auswertung der Dissoziationskurven sowie durch die Analyse der Fluoreszenzintensität. Die Versuche am faseroptischen Affinitätssensor zeigten, dass DNA-DNA-Hybride sowohl von Oligonukleotiden als auch von PCR-Produkten ein typisches Dissoziationsverhalten aufweisen, wobei fehlgepaarte Hybride eine signifikant schnellere Dissoziation zeigen als perfekt passende Hybride. Dieser Geschwindigkeitsunterschied lässt sich durch den Vergleich der jeweiligen kinetischen Geschwindigkeitskonstanten kD quantitativ erfassen. Da die Kopplung des Analyten an der Chipoberfläche sowie die Hybridisierungs- und Dissoziationsparameter essentiell für die Methodenentwicklung war, wurden die Parameter für ein optimales Spotting und die Immobilisierung von PCR-Produkten ermittelt. Getestet wurden die affine Kopplung von biotinylierten PCR-Produkten an Streptavidin-, Avidin- und NeutrAvidin-Oberflächen sowie die kovalente Bindung von phosphorylierten Amplifikaten mit der EDC/Methylimidazol-Methode. Die besten Ergebnisse sowohl in Spotform und -homogenität als auch im Signal/Rausch-Verhältnis wurden an NeutrAvidin-Oberflächen erreicht. Für die Etablierung der Mikroarray-Genotypisierungsmethode durch kinetische Analyse nach einem Hybridisierungsexperiment wurden Sondenlänge, Puffersystem, Spotting-Konzentration des Analyten sowie Temperatur optimiert. Das Analysensystem erlaubte es, PCR-Produkte mit einer Konzentration von 250 ng/µl in einem HEPES-EDTA-NaCl-Puffer auf mit NeutrAvidin beschichtete Glasträger zu spotten. In den anschließenden Hybridisierungs- und Dissoziationsexperimenten bei 30 °C konnte die Diskriminierung von homocygoter Wildtyp- und homocygoter Mutanten- sowie heterocygoter DNA am Beispiel von Oligonukleotid-Hybriden erreicht werden. In einer Gruppe von 24 homocygoten Patienten wurde ein Polymorphismus im SULT1A1-Gen analysiert. Sowohl durch kinetische Auswertung als auch mit der Analyse der Fluoreszenzintensität wurde der Genotyp der Proben identifiziert. Die Ergebnisse wurden mit dem Referenzverfahren, der Restriktionschnittstellenanalyse (PCR-RFLP) validiert. Lediglich ein Genotyp wurde falsch bestimmt, die Genauigkeit lag bei 96%. In einer Gruppe von 44 Patienten wurde der Genotyp eines SNP in der Adiponectin-Promotor-Region untersucht. Nach Vergleich der Analysenergebnisse mit denen eines Referenzverfahrens konnten lediglich 14 der untersuchten Genotypen bestätigt werden. Ursache für die unzureichende Genauigkeit der Methode war vor allem das schlechte Signal/Rausch-Verhältnis. Zusammenfassend kann gesagt werden, dass das in dieser Arbeit entwickelte Analysesystem für die Genotypisierung von Einzelpunktmutationen geeignet ist, homocygote Patientenproben zuverlässig zu analysieren. Prinzipiell ist das auch bei heterocygoter DNA möglich. Da nach aktuellem Kenntnisstand eine SNP-Analysemethode an immobilisierten PCR-Produkten noch nicht veröffentlicht wurde, stellt das hier entwickelte Verfahren eine Alternative zu bisher bekannten Mikroarray-Verfahren dar. Als besonders vorteilhaft erweist sich der reverse Ansatz der Methode. Der hier vorgestellte Ansatz ist eine kostengünstigere und weniger hoch dimensionierte Lösung für Fragestellungen beispielsweise in der Ernährungswissenschaft, bei denen meist eine mittlere Anzahl Patienten auf nur einige wenige SNPs zu untersuchen ist. Wenn es gelingt, durch die Weiterentwicklung der Hardware bzw. weiterer Optimierung, eine Verbesserung des Signal/Rausch-Verhältnisses und damit die Diskriminierung von heterocygoter DNA zu erreichen, kann diese Methode zukünftig bei der Analyse von mittelgroßen Patientengruppen alternativ zu anderen Genotypisierungsmethoden verwendet werden. N2 - The aim of this thesis was the development of a SNP genotyping method involving PCR products immobilised on microarrays. For the analysis a fibre optic affinity biosensor and a flow-through biochip scanner were used. Fluorescent probes were hybridized with the immobilised PCR products. In order to start the dissociation process the surface was rinsed with buffer and the fluorescence intensity was measured. Two different cases were studied: First, the full-matched DNA hybrid (wildtyp single strand with complementary wildtype single strand), second the mis-matched hybrid (wildtype single strand and mutant single strand). After determinating the reaction rates (kD) as kinetic parameter the kD values of both cases were compared. The experiments showed a significant difference in the kD value of the full- and the mis-match hybrids. Therefore, mutant and wildtype DNA were discriminated by kinetic analysis of the dissociation process and analysis of the fluorescence intensity. To set up the complete analysis process the reaction parameters like coupling of the PCR products had to be optimised. Both affininty coupled (streptavidin, neutravidin, avidin - biotin) and covalent methods (EDC/methylimidazol) were carried out. Best results in spot homogeinity and spot appearance were obtained with coupling of biotinylated PCR products on neutravidin coated chip surfaces. Additionally, the length of the probe, the spotting concentration, the spotting buffer and the reaction temperature were optimised. In the optimised analysis PCR products (250 µg/µl) were spotted onto neutravidin coated surfaces. The hybridisation and dissociation processes were carried out at 30°C. A HEPES-EDTA-NaCl buffer was used for spotting, diluting of the fluorescent probe and rinsing the microarray surface. A fluorescent probe was used with 13 nucleotides in length. The mis- or full-matching base indicating the polymorphism was located in the center position of the probe. The analysis system was tested with the genomic DNA of a group of 24 homocygote individuals with a SNP in the SULT1A1 gene region. The hybridisation and dissociation processes were carried out and the reaction rates were determinated. Subsequently after the analysis in the flow-through biochip scanner the fluorescence intensity of the spots were measured. The results showed very good comparability with results of a PCR-RFLP analysis (one false genotype). Additionally, a group of 44 heterocygote DNA samples with one SNP in the adiponectin promotor region were also genotyped. Compared to a reference method only 14 genotypes were correctly determined. This was mostly due to a low signal-noise-ratio and needs to be further investigated. Besides the problem in analysing heterocygote DNA samples the developed analysis system is very useful for genotyping SNP in homocygote DNA samples. The successful analysis of heterocygote sample is principally possible and with further investigations/optimisation, a better analysis should be possible. The most important advantage of the developed method is the reverse approach of binding PCR products at the surface instead of oligonucleotides. This allows the parallel genotyping of several individuals. Other advantages include low costs and medium sized dimensions in terms of throughput. KW - Einzelbasenaustausch KW - SNP KW - Mikrochip KW - DNA-Chip KW - SULT1A1 KW - Adiponectin KW - kinetische Analyse KW - Dissoziation KW - Durchfluß-Biochip-Scanner KW - Fließsystem KW - single nucleotide polymorphisms KW - SNP KW - microarray KW - DNA KW - kinetic analysis KW - dissociation KW - SULT1A1 KW - flow-through biochip scanner Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-0001853 ER - TY - JOUR A1 - Poeste, Simon T1 - Analyse von transgenen Kartoffelpflanzen mit veränderter cytosolischer Phosphorylase (Ph2) Aktivität Y1 - 2004 ER - TY - THES A1 - Kempa, Stefan T1 - Analysen zur Stressantwort von Arabidopsis thaliana unter Schwefelmangelbedingungen : Studien zur Funktion der Dehydroascorbatreduktase in vivo Y1 - 2004 CY - Potsdam ER - TY - JOUR A1 - Obel, Nicolai A1 - Usadel, Björn A1 - Choo, Tze Siang A1 - Pauly, Markus T1 - Analysing cell wall biosynthesis to study its role in biotic and abiotic stress reactions Y1 - 2004 SN - 3-00-011587-0 ER - TY - THES A1 - Daub, Carsten Oliver T1 - Analysis of integrated transcriptomics and metabolomics data : a systems biology approach N2 - Moderne Hochdurchsatzmethoden erlauben die Messung einer Vielzahl von komplementären Daten und implizieren die Existenz von regulativen Netzwerken auf einem systembiologischen Niveau. Ein üblicher Ansatz zur Rekonstruktion solcher Netzwerke stellt die Clusteranalyse dar, die auf einem Ähnlichkeitsmaß beruht. Wir verwenden das informationstheoretische Konzept der wechselseitigen Information, das ursprünglich für diskrete Daten definiert ist, als Ähnlichkeitsmaß und schlagen eine Erweiterung eines für gewöhnlich für die Anwendung auf kontinuierliche biologische Daten verwendeten Algorithmus vor. Wir vergleichen unseren Ansatz mit bereits existierenden Algorithmen. Wir entwickeln ein geschwindigkeitsoptimiertes Computerprogramm für die Anwendung der wechselseitigen Information auf große Datensätze. Weiterhin konstruieren und implementieren wir einen web-basierten Dienst fuer die Analyse von integrierten Daten, die durch unterschiedliche Messmethoden gemessen wurden. Die Anwendung auf biologische Daten zeigt biologisch relevante Gruppierungen, und rekonstruierte Signalnetzwerke zeigen Übereinstimmungen mit physiologischen Erkenntnissen. N2 - Recent high-throughput technologies enable the acquisition of a variety of complementary data and imply regulatory networks on the systems biology level. A common approach to the reconstruction of such networks is the cluster analysis which is based on a similarity measure. We use the information theoretic concept of the mutual information, that has been originally defined for discrete data, as a measure of similarity and propose an extension to a commonly applied algorithm for its calculation from continuous biological data. We compare our approach to previously existing algorithms. We develop a performance optimised software package for the application of the mutual information to large-scale datasets. Furthermore, we design and implement a web-based service for the analysis of integrated data measured with different technologies. Application to biological data reveals biologically relevant groupings and reconstructed signalling networks show agreements with physiological findings. KW - Transinformation KW - wechselseitige Information KW - Ähnlichkeitsmaß KW - Genexpression KW - mutual information KW - distance measure KW - gene expression Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-0001251 ER - TY - JOUR A1 - Scheller, Frieder W. A1 - Bier, Frank Fabian T1 - Analytical Biochemistry (Editorial) Y1 - 2004 ER - TY - JOUR A1 - Couper-Kuhlen, Elizabeth T1 - Analyzing language in interaction : the practice of never mind Y1 - 2004 ER - TY - BOOK A1 - Heimann, Heinz-Dieter T1 - Andacht beherschen : Fürstliche Frömmigkeit und höfische Repräsentation : Kurfürst Friedrichs II von Brandenburg Y1 - 2004 SN - 84-8021-491-0 ER - TY - JOUR A1 - Eckstein, Lars T1 - Andrew Salkey Y1 - 2004 SN - 3-520-83804-4 ER - TY - JOUR A1 - Prengel, Annedore A1 - Heinzel, Friederike T1 - Anerkennungs- und Missachtungsrituale in schulischen Geschlechterverhältnissen Y1 - 2004 ER - TY - JOUR A1 - Janz, Norbert T1 - Anger,T., Islam in der Schule; Berlin, Duncker & Humblot, 2003 BT - Islam in der Schule Y1 - 2004 SN - 0948-0471 ER - TY - JOUR A1 - Jeltsch, Florian A1 - Tews, Jörg A1 - Brose, Ulrich A1 - Grimm, Volker A1 - Tielbörger, Katja A1 - Wichmann, Matthias A1 - Schwager, Monika T1 - Animal species diversity driven by habitat heterogeneity/diversity : the importance of keystone structures N2 - In a selected literature survey we reviewed studies on the habitat heterogeneity-animal species diversity relationship and evaluated whether there are uncertainties and biases in its empirical support. We reviewed 85 publications for the period 1960-2003. We screened each publication for terms that were used to define habitat heterogeneity, the animal species group and ecosystem studied, the definition of the structural variable, the measurement of vegetation structure and the temporal and spatial scale of the study. The majority of studies found a positive correlation between habitat heterogeneity/diversity and animal species diversity. However, empirical support for this relationship is drastically biased towards studies of vertebrates and habitats under anthropogenic influence. In this paper we show that ecological effects of habitat heterogeneity may vary considerably between species groups depending on whether structural attributes are perceived as heterogeneity or fragmentation. Possible effects may also vary relative to the structural variable measured. Based upon this, we introduce a classification framework that may be used for across-studies comparisons. Moreover, the effect of habitat heterogeneity for one species group may differ in relation to the spatial scale. In several studies, however, different species groups are closely linked to 'keystone structures' that determine animal species diversity by their presence. Detecting crucial keystone structures of the vegetation has profound implications for nature conservation and biodiversity management. Y1 - 2004 ER - TY - JOUR A1 - Schneider, Hans Julius T1 - Anliegen und Ambivalenzen postmodernen Denkens Y1 - 2004 SN - 1437-0956 ER - TY - JOUR A1 - Klein, Eckart T1 - Anmerkung zum Beschluß des 2. Senats des BVerfG zur Bindung staatlicher Organe an Entscheidungen des EGMR Y1 - 2004 ER - TY - JOUR A1 - Esser, Günter A1 - Wyschkon, Anne A1 - Schmidt, Martin H. T1 - Anmerkungen Y1 - 2004 ER - TY - BOOK A1 - von Humboldt, Alexander ED - Ette, Ottmar ED - Lubrich, Oliver T1 - Ansichten der Kordilleren und Monumente der eingeborenen Völker Amerikas T3 - Die Andere Bibliothek Y1 - 2004 SN - 3-8218-4538-4 PB - Eichborn CY - Frankfurt am Main ER - TY - JOUR A1 - Reichard, Christoph T1 - Ansätze zu Performance Measurement in deutschen Kommunen : eine Bewertung ihres Entwicklungsstandes und ihrer Wirksamkeit Y1 - 2004 ER - TY - JOUR A1 - Yenesew, Abiy A1 - Induli, M. A1 - Derese, Solomon A1 - Midiwo, Jacob O. A1 - Heydenreich, Matthias A1 - Peter, Martin G. A1 - Akala, Hoseah M. A1 - Wangui, Julia A1 - Liyala, Pamela A1 - Waters, Norman C. T1 - Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica N2 - The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 +/- 1.1 and 5.3 +/- 0.7 mug/ml, respectively. From this extract, a new chalcone, 2,3,4,4'-tetrahydroxy-5- prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'- prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti- plasmodial principles. The structures were determined on the basis of spectroscopic evidence. (C) 2004 Elsevier Ltd. All rights reserved Y1 - 2004 SN - 0031-9422 ER - TY - JOUR A1 - Rohn, Sascha A1 - Rawel, Harshadrai Manilal A1 - Kroll, Jürgen T1 - Antioxidant activity of protein-bound quercetin N2 - Bovine serum albumin (BSA) was derivatized by covalent attachment of different amounts of quercetin (ratios of BSA : quercetin were 20:1, 10:1, 7:1, 5:1, 2:1 (w/w)). The antioxidant activity of the protein-phenol derivatives was investigated using a modified TEAC assay. The results show that the covalent attachment of quercetin to BSA decreases the total antioxidant activity in comparison to an equivalent amount of free quercetin depending on the degree of derivatization. The derivative with the highest amount of covalently bound quercetin (2:1 derivative) showed an antioxidant activity of only 79% compared to an equivalent amount of free quercetin. After the enzymatic proteolysis of the BSA quercetin derivatives with trypsin, the total antioxidant activity of the degradation products increases in comparison to the respective undigested derivatives, but does not reach the activity of an equivalent amount of free quercetin. Even after 240 minutes of tryptic degradation there is still a lack in antioxidant activity (for the 7:1 derivative nearly 33%) as compared to free quercetin. Y1 - 2004 UR - http://pubs.acs.org/cgi-bin/article.cgi/jafcau/2004/52/i15/html/jf0496797.html ER - TY - JOUR A1 - Gronau, Norbert A1 - Uslar, Mathias T1 - Antipattern zur Potenzial-Analyse mittels KMDL in wissensintensiven Prozessen Y1 - 2004 SN - 3-936771-31-6 ER - TY - THES A1 - Helms, Andreas T1 - Anwendung des Mikrogravitationslinseneffekts zur Untersuchung astronomischer Objekte N2 - Die Untersuchung mikrogelinster astronomischer Objekte ermöglicht es, Informationen über die Größe und Struktur dieser Objekte zu erhalten. Im ersten Teil dieser Arbeit werden die Spektren von drei gelinsten Quasare, die mit dem Potsdamer Multi Aperture Spectrophotometer (PMAS) erhalten wurden, auf Anzeichen für Mikrolensing untersucht. In den Spektren des Vierfachquasares HE 0435-1223 und des Doppelquasares HE 0047-1756 konnten Hinweise für Mikrolensing gefunden werden, während der Doppelquasar UM 673 (Q 0142--100) keine Anzeichen für Mikrolensing zeigt. Die Invertierung der Lichtkurve eines Mikrolensing-Kausik-Crossing-Ereignisses ermöglicht es, das eindimensionale Helligkeitsprofil der gelinsten Quelle zu rekonstruieren. Dies wird im zweiten Teil dieser Arbeit untersucht. Die mathematische Beschreibung dieser Aufgabe führt zu einer Volterra'schen Integralgleichung der ersten Art, deren Lösung ein schlecht gestelltes Problem ist. Zu ihrer Lösung wird in dieser Arbeit ein lokales Regularisierungsverfahren angewendet, das an die kausale Strukture der Volterra'schen Gleichung besser angepasst ist als die bisher verwendete Tikhonov-Phillips-Regularisierung. Es zeigt sich, dass mit dieser Methode eine bessere Rekonstruktion kleinerer Strukturen in der Quelle möglich ist. Weiterhin wird die Anwendbarkeit der Regularisierungsmethode auf realistische Lichtkurven mit irregulärem Sampling bzw. größeren Lücken in den Datenpunkten untersucht. N2 - The study of microlensed astronomical objects can reveal information about the size and the structure of these objects. In the first part of this thesis we analyze the spectra of three lensed quasars obtained with the Potsdam Multi Aperture Spectrophotometer (PMAS). The spectra of the quadrupole quasar HE 0435--1223 and the double quasar HE 0047--1756 show evidence for microlensing whereas in the double quasar UM 673 (Q 0142--100) no evidence for microlensing could be found. By inverting the lightcurve of a microlensing caustic crossing event the one dimensional luminosity profile of the lensed source can be reconstructed. This is investigated in the second part of this thesis.The mathematical formulation of this problem leads to a Volterra integral equation of the first kind, whose solution is an ill-posed problem. For the solution we use a local regularization method which is better adapted to the causal structure of the Volterra integral equation compared to the so far used Tikhonov-Phillips regularization. Furthermore we show that this method is more robust on reconstructing small structures in the source profile. We also study the influence of irregular sampled data and gaps in the lightcurve on the result of the inversion. T2 - Anwendung des Mikrogravitationslinseneffekts zur Untersuchung astronomischer Objekte KW - Gravitationslinseneffekt KW - Mikrolensing KW - Quasar KW - Regularisierung KW - Schlecht gestelltes Problem KW - gravitational lensing KW - microlensing KW - quasar KW - regularization KW - ill-posed problem Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-0001532 ER - TY - JOUR A1 - Wendler, Wiebke A1 - Jessel, Beate T1 - Anwendung und Akzeptanz der FFH-Richtlinie in Deutschland und in Frankreich : ein Vergleich in ausgewählten Gemeinden N2 - Application and Acceptance of the Habitats Directive in Germany and France - Comparison of Selected Areas. Since 1992, when the Habitats Directive (92/43/EWG) came into effect, all EU member states are obligated to contribute to the establishment of a coherent ecological framework of special protection areas, called Natura 2000. The guideline states both protection objects and protection aims more precisely but its implementation is, to a large extent, left to the member states. In the neighbouring states Germany and France the organisation report strategy, and area management of the Natura 2000 areas differ significantly. Based on these conditions, in both countries two exemplary regions (mountain range and low mountain range) with 3 Natura 2000-areas were selected. In exemplary municipalities the local decision-makers and other relevant activists were interviewed regarding their acceptance of Natura 2000. The results showed altogether a higher acceptance in the 12 German municipalities than in the 12 French but at the same time an extensive insecurity regarding the new obligations on order to implement the protection system. In the French examples the lack of public participation organised by the state government contributed to a reduced acceptance during the first years of the implementation of the Habitats Guideline. Besides, crucial elements for a local acceptance of the Natura 2000 system in both states were the land owners, existing plans and development aims of the municipality, land use and a possibly existing protection status of the area. Additionally the study showed that a transparent establishment of a management plan offers the opportunity to co-ordinate different land use and protection interests. The designation of a separate area co-ordinator for each Natura 2000-area, at the same time contact for the local community like in France, can provide a valuable, confidence-building measure. Y1 - 2004 ER -