TY  - JOUR
A1  - Abdalla, H.
A1  - Adam, R.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Armstrong, T.
A1  - Ashkar, H.
A1  - Backes, M.
A1  - Baghmanyan, V.
A1  - Martins, V. Barbosa
A1  - Barnacka, A.
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Berge, D.
A1  - Bernlohr, K.
A1  - Bi, B.
A1  - Bottcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - de Lavergne, M. de Bony
A1  - Bordas, Pol
A1  - Breuhaus, M.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Buchele, M.
A1  - Bulik, T.
A1  - Bylund, T.
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Chand, T.
A1  - Chandra, S.
A1  - Chen, A.
A1  - Cotter, G.
A1  - Curylo, M.
A1  - Mbarubucyeye, J. Damascene
A1  - Davids, I. D.
A1  - Davies, J.
A1  - Deil, C.
A1  - Devin, J.
A1  - deWilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, A.
A1  - Doroshenko, V.
A1  - Duffy, C.
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Eichhorn, F.
A1  - Einecke, S.
A1  - Emery, G.
A1  - Ernenwein, J. -P.
A1  - Feijen, K.
A1  - Fegan, S.
A1  - Fiasson, A.
A1  - de Clairfontaine, G. Fichet
A1  - Fontaine, G.
A1  - Funk, S.
A1  - Fussling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Giavitto, G.
A1  - Giunti, L.
A1  - Glawion, D.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M. -H.
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Hermann, G.
A1  - Hinton, J. A.
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, T. L.
A1  - Holler, M.
A1  - Horbe, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Jamrozy, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jardin-Blicq, A.
A1  - Joshi, V.
A1  - Jung-Richardt, I.
A1  - Kasai, E.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu.
A1  - Konno, R.
A1  - Kosack, K.
A1  - Kostunin, D.
A1  - Kreter, M.
A1  - Lamanna, G.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Levy, C.
A1  - Lohse, T.
A1  - Lypova, I.
A1  - Mackey, J.
A1  - Majumdar, J.
A1  - Malyshev, D.
A1  - Malyshev, D.
A1  - Marandon, V.
A1  - Marchegiani, P.
A1  - Marcowith, Alexandre
A1  - Mares, A.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Meyer, M.
A1  - Mitchell, A.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Montanari, A.
A1  - Moore, C.
A1  - Morris, P.
A1  - Moulin, Emmanuel
A1  - Muller, J.
A1  - Murach, T.
A1  - Nakashima, K.
A1  - Nayerhoda, A.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - O'Brien, Patrick
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Olivera-Nieto, L.
A1  - Wilhelmi, E. de Ona
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Panny, S.
A1  - Parsons, R. D.
A1  - Peron, G.
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V.
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puhlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reichherzer, P.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Remy, Q.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V.
A1  - Sailer, S.
A1  - Sanchez, D. A.
A1  - Santangelo, A.
A1  - Sasaki, M.
A1  - Scalici, M.
A1  - Schussler, F.
A1  - Schutte, H. M.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Specovius, A.
A1  - Spencer, S.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Sun, L.
A1  - Steenkamp, R.
A1  - Stegmann, C.
A1  - Steinmassl, S.
A1  - Steppa, C.
A1  - Takahashi, T.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Tomankova, L.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Volk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Watson, J.
A1  - Werner, F.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wong, Yu Wun
A1  - Yusafzai, A.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zargaryan, D.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zhu, S. J.
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zouari, S.
A1  - Zywucka, N.
T1  - An extreme particle accelerator in the Galactic plane
BT  - HESS J1826-130
JF  - Astronomy and astrophysics : an international weekly journal
N2  - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02 <br /> (stat)degrees <br /> stat degrees +/- 0.05 <br /> (sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2 <br /> (+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW  - ISM: supernova remnants
KW  - ISM: clouds
KW  - gamma rays: general
KW  - gamma rays:
KW  - ISM
Y1  - 2020
U6  - https://doi.org/10.1051/0004-6361/202038851
SN  - 0004-6361
SN  - 1432-0746
VL  - 644
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Adam, Remi
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, Masanori
A1  - Arcaro, C
A1  - Armand, Catherine
A1  - Armstrong, T.
A1  - Egberts, Kathrin
T1  - Very high energy γ-ray emission from two blazars of unknown redshift and upper limits on their distance
JF  - Monthly Notices of the Royal Astronomical Society
N2  - We report on the detection of very high energy (VHE; E > 100 GeV) gamma-ray emission from the BL Lac objects KUV 00311-1938 and PKS 1440-389 with the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observations were accompanied or preceded by multiwavelength observations with Fermi/LAT, XRT and UVOT onboard the Swift satellite, and ATOM. Based on an extrapolation of the Fermi/LAT spectrum towards the VHE gamma-ray regime, we deduce a 95 per cent confidence level upper limit on the unknown redshift of KUV 00311-1938 of z < 0.98 and of PKS 1440-389 of z < 0.53. When combined with previous spectroscopy results, the redshift of KUV 00311-1938 is constrained to 0.51 <= z < 0.98 and of PKS 1440-389 to 0.14 (sic) z < 0.53.
KW  - BL Lacertae objects: individual
KW  - galaxies: high-redshift
KW  - gamma-rays: general
KW  - Resolved and unresolved sources as a function of wavelength
Y1  - 2020
VL  - 494
IS  - 4
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Abdirashid, Hashim
A1  - Lenhard, Michael
T1  - Say it with double flowers
JF  - Journal of experimental botany
N2  - Every year, lovers world-wide rely on mutants to show their feelings on Valentine's Day. This is because many of the most popular ornamental flowering plants have been selected to form extra petals at the expense of reproductive organs to enhance their attractiveness and aesthetic value to humans. This so-called 'double flower' (DF) phenotype, first described more than 2000 years ago (Meyerowitz et al., 1989) is present, for example, in many modern roses, carnations, peonies, and camellias. Gattolin et al. (2020) now identify a unifying explanation for the molecular basis of many of these DF cultivars.
KW  - ABCE model
KW  - APETALA2
KW  - double flowers
KW  - flower development
KW  - homoeotic
KW  - mutants
KW  - microRNA172
Y1  - 2020
U6  - https://doi.org/10.1093/jxb/eraa109
SN  - 0022-0957
SN  - 1460-2431
VL  - 71
IS  - 9
SP  - 2469
EP  - 2471
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Adam, Maurits
A1  - Elsner, Birgit
T1  - The impact of salient action effects on 6-, 7-, and 11-month-olds’ goal-predictive gaze shifts for a human grasping action
JF  - PLOS ONE
N2  - When infants observe a human grasping action, experience-based accounts predict that all infants familiar with grasping actions should be able to predict the goal regardless of additional agency cues such as an action effect. Cue-based accounts, however, suggest that infants use agency cues to identify and predict action goals when the action or the agent is not familiar. From these accounts, we hypothesized that younger infants would need additional agency cues such as a salient action effect to predict the goal of a human grasping action, whereas older infants should be able to predict the goal regardless of agency cues. In three experiments, we presented 6-, 7-, and 11-month-olds with videos of a manual grasping action presented either with or without an additional salient action effect (Exp. 1 and 2), or we presented 7-month-olds with videos of a mechanical claw performing a grasping action presented with a salient action effect (Exp. 3). The 6-month-olds showed tracking gaze behavior, and the 11-month-olds showed predictive gaze behavior, regardless of the action effect. However, the 7-month-olds showed predictive gaze behavior in the action-effect condition, but tracking gaze behavior in the no-action-effect condition and in the action-effect condition with a mechanical claw. The results therefore support the idea that salient action effects are especially important for infants' goal predictions from 7 months on, and that this facilitating influence of action effects is selective for the observation of human hands.
KW  - attention
KW  - eye movements
KW  - infants perception
KW  - mechanisms
KW  - origins
Y1  - 2020
U6  - https://doi.org/10.1371/journal.pone.0240165
SN  - 1932-6203
VL  - 15
IS  - 10
PB  - Public Library of Science
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Adnan, Hassan Sami
A1  - Matthews, Sam
A1  - Hackl, M.
A1  - Das, P. P.
A1  - Manaswini, Manisha
A1  - Gadamsetti, S.
A1  - Filali, Maroua
A1  - Owoyele, Babajide
A1  - Santuber, Joaquín
A1  - Edelman, Jonathan
T1  - Human centered AI design for clinical monitoring and data management
JF  - European journal of public health : official journal of the European Health Association
N2  - In clinical settings, significant resources are spent on data collection and monitoring patients' health parameters to improve decision-making and provide better care. With increased digitization, the healthcare sector is shifting towards implementing digital technologies for data management and in administration. New technologies offer better treatment opportunities and streamline clinical workflow, but the complexity can cause ineffectiveness, frustration, and errors. To address this, we believe digital solutions alone are not sufficient. Therefore, we take a human-centred design approach for AI development, and apply systems engineering methods to identify system leverage points. We demonstrate how automation enables monitoring clinical parameters, using existing non-intrusive sensor technology, resulting in more resources toward patient care. Furthermore, we provide a framework on digitization of clinical data for integration with data management.
Y1  - 2020
U6  - https://doi.org/10.1093/eurpub/ckaa165.225
SN  - 1101-1262
SN  - 1464-360X
VL  - 30
IS  - 5
SP  - V86
EP  - V86
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Adnan, Hassan Sami
A1  - Srsic, Amanda
A1  - Venticich, Pete Milos
A1  - Townend, David M.R.
T1  - Using AI for mental health analysis and prediction in school surveys
JF  - European journal of public health
N2  - Background:
Childhood and adolescence are critical stages of life for mental health and well-being. Schools are a key setting for mental health promotion and illness prevention. One in five children and adolescents have a mental disorder, about half of mental disorders beginning before the age of 14. Beneficial and explainable artificial intelligence can replace current paper- based and online approaches to school mental health surveys. This can enhance data acquisition, interoperability, data driven analysis, trust and compliance. This paper presents a model for using chatbots for non-obtrusive data collection and supervised machine learning models for data analysis; and discusses ethical considerations pertaining to the use of these models.

Methods:
For data acquisition, the proposed model uses chatbots which interact with students. The conversation log acts as the source of raw data for the machine learning. Pre-processing of the data is automated by filtering for keywords and phrases.
Existing survey results, obtained through current paper-based data collection methods, are evaluated by domain experts (health professionals). These can be used to create a test dataset to validate the machine learning models. Supervised learning
can then be deployed to classify specific behaviour and mental health patterns.

Results:
We present a model that can be used to improve upon current paper-based data collection and manual data analysis methods. An open-source GitHub repository contains necessary tools and components of this model. Privacy is respected through
rigorous observance of confidentiality and data protection requirements. Critical reflection on these ethics and law aspects is included in the project.

Conclusions:
This model strengthens mental health surveillance in schools. The same tools and components could be applied to other public health data. Future extensions of this model could also incorporate unsupervised learning to find clusters and patterns
of unknown effects.
KW  - ethics
KW  - artificial intelligence
KW  - adolescent
KW  - child
KW  - confidentiality
KW  - health personnel
KW  - mental disorders
KW  - mental health
KW  - personal satisfaction
KW  - privacy
KW  - school (environment)
KW  - statutes and laws
KW  - public health medicine
KW  - surveillance
KW  - medical
KW  - prevention
KW  - datasets
KW  - machine learning
KW  - supervised machine learning
KW  - data analysis
Y1  - 2020
U6  - https://doi.org/10.1093/eurpub/ckaa165.336
SN  - 1101-1262
SN  - 1464-360X
VL  - 30
SP  - V125
EP  - V125
PB  - Oxford Univ. Press
CY  - Oxford [u.a.]
ER  - 
TY  - JOUR
A1  - Aga-Barfknecht, Heja
A1  - Hallahan, Nicole
A1  - Gottmann, Pascal
A1  - Jähnert, Markus
A1  - Osburg, Sophie
A1  - Schulze, Gunnar
A1  - Kamitz, Anne
A1  - Arends, Danny
A1  - Brockmann, Gudrun
A1  - Schallschmidt, Tanja
A1  - Lebek, Sandra
A1  - Chadt, Alexandra
A1  - Al-Hasani, Hadi
A1  - Joost, Hans-Georg
A1  - Schürmann, Annette
A1  - Vogel, Heike
T1  - Identification of novel potential type 2 diabetes genes mediating beta-cell loss and hyperglycemia using positional cloning
JF  - Frontiers in genetics
N2  - Type 2 diabetes (T2D) is a complex metabolic disease regulated by an interaction of genetic predisposition and environmental factors. To understand the genetic contribution in the development of diabetes, mice varying in their disease susceptibility were crossed with the obese and diabetes-prone New Zealand obese (NZO) mouse. Subsequent whole-genome sequence scans revealed one major quantitative trait loci (QTL),Nidd/DBAon chromosome 4, linked to elevated blood glucose and reduced plasma insulin and low levels of pancreatic insulin. Phenotypical characterization of congenic mice carrying 13.6 Mbp of the critical fragment of DBA mice displayed severe hyperglycemia and impaired glucose clearance at week 10, decreased glucose response in week 13, and loss of beta-cells and pancreatic insulin in week 16. To identify the responsible gene variant(s), further congenic mice were generated and phenotyped, which resulted in a fragment of 3.3 Mbp that was sufficient to induce hyperglycemia. By combining transcriptome analysis and haplotype mapping, the number of putative responsible variant(s) was narrowed from initial 284 to 18 genes, including gene models and non-coding RNAs. Consideration of haplotype blocks reduced the number of candidate genes to four (Kti12,Osbpl9,Ttc39a, andCalr4) as potential T2D candidates as they display a differential expression in pancreatic islets and/or sequence variation. In conclusion, the integration of comparative analysis of multiple inbred populations such as haplotype mapping, transcriptomics, and sequence data substantially improved the mapping resolution of the diabetes QTLNidd/DBA. Future studies are necessary to understand the exact role of the different candidates in beta-cell function and their contribution in maintaining glycemic control.
KW  - type 2 diabetes
KW  - beta-cell loss
KW  - insulin
KW  - positional cloning
KW  - transcriptomics
KW  - haplotype
Y1  - 2020
U6  - https://doi.org/10.3389/fgene.2020.567191
SN  - 1664-8021
VL  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Agarwal, Ankit
A1  - Marwan, Norbert
A1  - Maheswaran, Rathinasamy
A1  - Öztürk, Ugur
A1  - Kurths, Jürgen
A1  - Merz, Bruno
T1  - Optimal design of hydrometric station networks based on complex network analysis
JF  - Hydrology and Earth System Sciences
N2  - Hydrometric networks play a vital role in providing information for decision-making in water resource management. They should be set up optimally to provide as much information as possible that is as accurate as possible and, at the same time, be cost-effective. Although the design of hydrometric networks is a well-identified problem in hydrometeorology and has received considerable attention, there is still scope for further advancement. In this study, we use complex network analysis, defined as a collection of nodes interconnected by links, to propose a new measure that identifies critical nodes of station networks. The approach can support the design and redesign of hydrometric station networks. The science of complex networks is a relatively young field and has gained significant momentum over the last few years in different areas such as brain networks, social networks, technological networks, or climate networks. The identification of influential nodes in complex networks is an important field of research. We propose a new node-ranking measure – the weighted degree–betweenness (WDB) measure – to evaluate the importance of nodes in a network. It is compared to previously proposed measures used on synthetic sample networks and then applied to a real-world rain gauge network comprising 1229 stations across Germany to demonstrate its applicability. The proposed measure is evaluated using the decline rate of the network efficiency and the kriging error. The results suggest that WDB effectively quantifies the importance of rain gauges, although the benefits of the method need to be investigated in more detail.
KW  - identifying influential nodes
KW  - climate networks
KW  - rainfall
KW  - streamflow
KW  - synchronization
KW  - precipitation
KW  - classification
KW  - events
Y1  - 2020
U6  - https://doi.org/10.5194/hess-24-2235-2020
SN  - 1027-5606
SN  - 1607-7938
VL  - 24
IS  - 5
SP  - 2235
EP  - 2251
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Al-Naji, Majd
A1  - Schlaad, Helmut
A1  - Antonietti, Markus
T1  - New (and old) monomers from biorefineries to make polymer chemistry more sustainable
JF  - Macromolecular rapid communications
N2  - This opinion article describes recent approaches to use the "biorefinery" concept to lower the carbon footprint of typical mass polymers, by replacing parts of the fossil monomers with similar or even the same monomer made from regrowing dendritic biomass. Herein, the new and green catalytic synthetic routes are for lactic acid (LA), isosorbide (IS), 2,5-furandicarboxylic acid (FDCA), and p-xylene (pXL). Furthermore, the synthesis of two unconventional lignocellulosic biomass derivable monomers, i.e., alpha-methylene-gamma-valerolactone (MeGVL) and levoglucosenol (LG), are presented. All those have the potential to enter in a cost-effective way, also the mass market and thereby recover lost areas for polymer materials. The differences of catalytic unit operations of the biorefinery are also discussed and the challenges that must be addressed along the synthesis path of each monomers.
KW  - biodegradable polymers
KW  - biorefineries
KW  - carbohydrate‐ based
KW  - monomers
KW  - green polymers
KW  - lignocellulosic biomass
Y1  - 2020
U6  - https://doi.org/10.1002/marc.202000485
SN  - 1022-1336
SN  - 1521-3927
VL  - 42
IS  - 3
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Al-Saedy, Ammar Jaffar Muhesin
A1  - Tarchanov, Nikolaj Nikolaevič
T1  - A degree theory for Lagrangian boundary value problems
JF  - Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University; mathematics & physics
N2  - We study those nonlinear partial differential equations which appear as Euler-Lagrange equations of variational problems. On defining weak boundary values of solutions to such equations we initiate the theory of Lagrangian boundary value problems in spaces of appropriate smoothness. We also analyse if the concept of mapping degree of current importance applies to Lagrangian problems.
N2  - Мы изучаем те нелинейные уравнения с частными производными, которые возникают как уравнения Эйлера-Лагранжа вариационных задач. Определяя слабые граничные значения решений таких уравнений, мы инициируем теорию лагранжевых краевых задач в функциональных пространствах подходящей гладкости. Мы также анализируем, применяется ли современная концепция степени отображения к лагранжевым проблемам.
KW  - nonlinear equations
KW  - Lagrangian system
KW  - weak boundary values
KW  - quasilinear Fredholm operators
KW  - mapping degree
Y1  - 2020
U6  - https://doi.org/10.17516/1997-1397-2020-13-1-5-25
SN  - 1997-1397
SN  - 2313-6022
VL  - 13
IS  - 1
SP  - 5
EP  - 25
PB  - Sibirskij Federalʹnyj Universitet
CY  - Krasnojarsk
ER  - 
TY  - JOUR
A1  - Albert, Justin Amadeus
A1  - Owolabi, Victor
A1  - Gebel, Arnd
A1  - Brahms, Clemens Markus
A1  - Granacher, Urs
A1  - Arnrich, Bert
T1  - Evaluation of the Pose Tracking Performance of the Azure Kinect and Kinect v2 for Gait Analysis in Comparison with a Gold Standard
BT  - A Pilot Study
JF  - Sensors
N2  - Gait analysis is an important tool for the early detection of neurological diseases and for the assessment of risk of falling in elderly people. The availability of low-cost camera hardware on the market today and recent advances in Machine Learning enable a wide range of clinical and health-related applications, such as patient monitoring or exercise recognition at home. In this study, we evaluated the motion tracking performance of the latest generation of the Microsoft Kinect camera, Azure Kinect, compared to its predecessor Kinect v2 in terms of treadmill walking using a gold standard Vicon multi-camera motion capturing system and the 39 marker Plug-in Gait model. Five young and healthy subjects walked on a treadmill at three different velocities while data were recorded simultaneously with all three camera systems. An easy-to-administer camera calibration method developed here was used to spatially align the 3D skeleton data from both Kinect cameras and the Vicon system. With this calibration, the spatial agreement of joint positions between the two Kinect cameras and the reference system was evaluated. In addition, we compared the accuracy of certain spatio-temporal gait parameters, i.e., step length, step time, step width, and stride time calculated from the Kinect data, with the gold standard system. Our results showed that the improved hardware and the motion tracking algorithm of the Azure Kinect camera led to a significantly higher accuracy of the spatial gait parameters than the predecessor Kinect v2, while no significant differences were found between the temporal parameters. Furthermore, we explain in detail how this experimental setup could be used to continuously monitor the progress during gait rehabilitation in older people.
KW  - motion capture
KW  - evaluation
KW  - human motion
KW  - RGB-D cameras
KW  - digital health
Y1  - 2020
U6  - https://doi.org/10.3390/s20185104
SN  - 1424-8220
VL  - 20
IS  - 18
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Albrecht, Torsten
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Glacial-cycle simulations of the Antarctic Ice Sheet with the Parallel Ice Sheet Model (PISM)
BT  - part 2: parameter ensemble analysis
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - The Parallel Ice Sheet Model (PISM) is applied to the Antarctic Ice Sheet over the last two glacial cycles (approximate to 210 000 years) with a resolution of 16 km. An ensemble of 256 model runs is analyzed in which four relevant model parameters have been systematically varied using full-factorial parameter sampling. Parameters and plausible parameter ranges have been identified in a companion paper (Albrecht et al., 2020) and are associated with ice dynamics, climatic forcing, basal sliding and bed deformation and represent distinct classes of model uncertainties. The model is scored against both modern and geologic data, including reconstructed grounding-line locations, elevation-age data, ice thickness, surface velocities and uplift rates. An aggregated score is computed for each ensemble member that measures the overall model-data misfit, including measurement uncertainty in terms of a Gaussian error model (Briggs and Tarasov, 2013). The statistical method used to analyze the ensemble simulation results follows closely the simple averaging method described in Pollard et al. (2016). 
This analysis reveals clusters of best-fit parameter combinations, and hence a likely range of relevant model and boundary parameters, rather than individual best-fit parameters. The ensemble of reconstructed histories of Antarctic Ice Sheet volumes provides a score-weighted likely range of sea-level contributions since the Last Glacial Maximum (LGM) of 9.4 +/- 4.1m (or 6.5 +/- 2.0 x 10(6) km(3)), which is at the upper range of most previous studies. The last deglaciation occurs in all ensemble simulations after around 12 000 years before present and hence after the meltwater pulse 1A (MWP1a). Our ensemble analysis also provides an estimate of parametric uncertainty bounds for the present-day state that can be used for PISM projections of future sea-level contributions from the Antarctic Ice Sheet.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-633-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 2
SP  - 633
EP  - 656
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Albrecht, Torsten
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Glacial-cycle simulations of the Antarctic Ice Sheet with the Parallel Ice Sheet Model (PISM)
BT  - Part 1: boundary conditions and climatic forcing
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Simulations of the glacial-interglacial history of the Antarctic Ice Sheet provide insights into dynamic threshold behavior and estimates of the ice sheet's contributions to global sea-level changes for the past, present and future. However, boundary conditions are weakly constrained, in particular at the interface of the ice sheet and the bedrock. Also climatic forcing covering the last glacial cycles is uncertain, as it is based on sparse proxy data. <br /> We use the Parallel Ice Sheet Model (PISM) to investigate the dynamic effects of different choices of input data, e.g., for modern basal heat flux or reconstructions of past changes of sea level and surface temperature. As computational resources are limited, glacial-cycle simulations are performed using a comparably coarse model grid of 16 km and various parameterizations, e.g., for basal sliding, iceberg calving, or for past variations in precipitation and ocean temperatures. In this study we evaluate the model's transient sensitivity to corresponding parameter choices and to different boundary conditions over the last two glacial cycles and provide estimates of involved uncertainties. We also discuss isolated and combined effects of climate and sea-level forcing. Hence, this study serves as a "cookbook" for the growing community of PISM users and paleo-ice sheet modelers in general. <br /> For each of the different model uncertainties with regard to climatic forcing, ice and Earth dynamics, and basal processes, we select one representative model parameter that captures relevant uncertainties and motivates corresponding parameter ranges that bound the observed ice volume at present. The four selected parameters are systematically varied in a parameter ensemble analysis, which is described in a companion paper.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-599-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 2
SP  - 599
EP  - 632
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Aldiyarov, Abdurakhman
A1  - Sokolov, Dmitriy
A1  - Akylbayeva, Aigerim
A1  - Nurmukan, Assel
A1  - Tokmoldin, Nurlan
T1  - On thermal stability of cryovacuum deposited CH4+H2O films
JF  - Low temperature physics
N2  - Whereas stable homogenous states of aqueous hydrocarbon solutions are typically observed at high temperatures and pressures far beyond the critical values corresponding to individual components, the stability of such system may be preserved upon transition into the region of metastable states at low temperatures and low pressures. This work is dedicated to the study of the thermal stability of a water-methane mixture formed by cryogenic vapor phase deposition. The obtained thin films were studied using vibrational spectroscopy in the temperature range of 16-180 K. During thermal annealing of the samples, characteristic vibrational C-H modes of methane were monitored alongside the chamber pressure to register both structural changes and desorption of the film material. The obtained results reveal that upon the co-deposition of methane and water, methane molecules appear both in non-bound and trapped states. The observed broadening of the characteristic C-H stretching mode at 3010 cm(-1) upon an increase in temperature of the sample from 16 to 90 K, followed by narrowing of the peak as the temperature is reduced back to 16 K, indicates localization of methane molecules within the water matrix at lower temperatures.
KW  - molecular crystals
KW  - water-methane films
KW  - vibrational spectroscopy
KW  - low
KW  - temperature
KW  - methane localization
Y1  - 2020
U6  - https://doi.org/10.1063/10.0002156
SN  - 1063-777X
SN  - 1090-6517
VL  - 46
IS  - 11
SP  - 1121
EP  - 1124
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Alexoudi, Xanthippi
A1  - Mallonn, Matthias
A1  - Keles, Engin
A1  - Poppenhäger, Katja
A1  - von Essen, Carolina
A1  - Strassmeier, Klaus
T1  - Role of the impact parameter in exoplanet transmission spectroscopy
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Context
Transmission spectroscopy is a promising tool for the atmospheric characterization of transiting exoplanets. Because the planetary signal is faint, discrepancies have been reported regarding individual targets. 

Aims
We investigate the dependence of the estimated transmission spectrum on deviations of the orbital parameters of the star-planet system that are due to the limb-darkening effects of the host star. We describe how the uncertainty on the orbital parameters translates into an uncertainty on the planetary spectral slope. 

Methods
We created synthetic transit light curves in seven different wavelength bands, from the near-ultraviolet to the near-infrared, and fit them with transit models parameterized by fixed deviating values of the impact parameter b. First, we performed a qualitative study to illustrate the effect by presenting the changes in the transmission spectrum slope with different deviations of b. Then, we quantified these variations by creating an error envelope (for centrally transiting, off-center, and grazing systems) based on a derived typical uncertainty on b from the literature. Finally, we compared the variations in the transmission spectra for different spectral types of host stars.

Results
Our simulations show a wavelength-dependent offset that is more pronounced at the blue wavelengths where the limb-darkening effect is stronger. This offset introduces a slope in the planetary transmission spectrum that becomes steeper with increasing b values. Variations of b by positive or negative values within its uncertainty interval introduce positive or negative slopes, thus the formation of an error envelope. The amplitude from blue optical to near-infrared wavelength for a typical uncertainty on b corresponds to one atmospheric pressure scale height and more. This impact parameter degeneracy is confirmed for different host types; K stars present prominently steeper slopes, while M stars indicate features at the blue wavelengths.

Conclusions
We demonstrate that transmission spectra can be hard to interpret, basically because of the limitations in defining a precise impact parameter value for a transiting exoplanet. This consequently limits a characterization of its atmosphere.
KW  - planets and satellites: atmospheres
KW  - planets and satellites: gaseous
KW  - planets
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-605378
SN  - 0004-6361
SN  - 1432-0746
VL  - 640
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Alirezaeizanjani, Zahra
A1  - Großmann, Robert
A1  - Pfeifer, Veronika
A1  - Hintsche, Marius
A1  - Beta, Carsten
T1  - Chemotaxis strategies of bacteria with multiple run modes
JF  - Science advances
N2  - Bacterial chemotaxis-a fundamental example of directional navigation in the living world-is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes-the flagella may, for example, push the cell body or wrap around it. How do the different run modes shape the chemotaxis strategy of a multimode swimmer? Here, we investigate chemotactic motion of the soil bacterium Pseudomonas putida as a model organism. By simultaneously tracking the position of the cell body and the configuration of its flagella, we demonstrate that individual run modes show different chemotactic responses in nutrition gradients and, thus, constitute distinct behavioral states. On the basis of an active particle model, we demonstrate that switching between multiple run states that differ in their speed and responsiveness provides the basis for robust and efficient chemotaxis in complex natural habitats.
KW  - exploit
KW  - flagellum
KW  - instability
KW  - time
Y1  - 2020
U6  - https://doi.org/10.1126/sciadv.aaz6153
SN  - 2375-2548
VL  - 6
IS  - 22
PB  - American Association for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Allroggen, Niklas
A1  - Beiter, Daniel
A1  - Tronicke, Jens
T1  - Ground-penetrating radar monitoring of fast subsurface processes
JF  - Geophysics
N2  - Earth and environmental sciences rely on detailed information about subsurface processes. Whereas geophysical techniques typically provide highly resolved spatial images, monitoring subsurface processes is often associated with enormous effort and, therefore, is usually limited to point information in time or space. Thus, the development of spatial and temporal continuous field monitoring methods is a major challenge for the understanding of subsurface processes. We have developed a novel method for ground-penetrating-radar (GPR) reflection monitoring of subsurface flow processes under unsaturated conditions and applied it to a hydrological infiltration experiment performed across a periglacial slope deposit in northwest Luxembourg. Our approach relies on a spatial and temporal quasicontinuous data recording and processing, followed by an attribute analysis based on analyzing differences between individual time steps. The results demonstrate the ability of time-lapse GPR monitoring to visualize the spatial and temporal dynamics of preferential flow processes with a spatial resolution in the order of a few decimeters and temporal resolution in the order of a few minutes. We observe excellent agreement with water table information originating from different boreholes. This demonstrates the potential of surface-based GPR reflection monitoring to observe the spatiotemporal dynamics of water movements in the subsurface. It provides valuable, and so far not accessible, information for example in the field of hydrology and pedology that allows studying the actual subsurface processes rather than deducing them from point information.
Y1  - 2020
U6  - https://doi.org/10.1190/GEO2019-0737.1
SN  - 0016-8033
SN  - 1942-2156
VL  - 85
IS  - 3
SP  - A19
EP  - A23
PB  - Society of Exploration Geophysicists
CY  - Tulsa
ER  - 
TY  - JOUR
A1  - Amaechi, Mary Chimaobi
A1  - Georgi, Doreen
T1  - On optional wh-/focus fronting in Igbo
BT  - a SYN-SEM-PHON interaction
JF  - Zeitschrift für Sprachwissenschaft
N2  - This paper discusses surface optionality in focus fronting in the Benue-Congo language Igbo. A focused XP can occur in-situ or ex-situ. We argue that the optionality does not have its origins in the syntax: in fact, exactly one focused XP has to move to the designated focus position in the left periphery in the syntax. The alternation between in-situ and ex-situ rather arises at PF: either the lowest or the topmost copy of the focus chain is pronounced. The choice is determined by semantic-pragmatic factors, i. e., we see an interaction between PF and LF. This constitutes a challenge for a strict version of the Y-model of grammar.
KW  - (A)over-bar-movement
KW  - focus realization
KW  - PF-optionality
KW  - Y-model
KW  - copy
KW  - pronounciation
KW  - Benue-Congo languages
Y1  - 2020
U6  - https://doi.org/10.1515/zfs-2020-2017
SN  - 0721-9067
SN  - 1613-3706
VL  - 39
IS  - 3
SP  - 299
EP  - 327
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Amen, Rahma
A1  - Nagel, Rebecca
A1  - Hedt, Maximilian
A1  - Kirschbaum, Frank
A1  - Tiedemann, Ralph
T1  - Morphological differentiation in African weakly electric fish (genus Campylomormyrus) relates to substrate preferences
JF  - Evolutionary Ecology
N2  - Under an ecological speciation scenario, the radiation of African weakly electric fish (genus Campylomormyrus) is caused by an adaptation to different food sources, associated with diversification of the electric organ discharge (EOD). This study experimentally investigates a phenotype-environment correlation to further support this scenario. Our behavioural experiments showed that three sympatric Campylomormyrus species with significantly divergent snout morphology differentially react to variation in substrate structure. While the short snout species (C. tamandua) exhibits preference to sandy substrate, the long snout species (C. rhynchophorus) significantly prefers a stone substrate for feeding. A third species with intermediate snout size (C. compressirostris) does not exhibit any substrate preference. This preference is matched with the observation that long-snouted specimens probe deeper into the stone substrate, presumably enabling them to reach prey more distant to the substrate surface. These findings suggest that the diverse feeding apparatus in the genus Campylomormyrus may have evolved in adaptation to specific microhabitats, i.e., substrate structures where these fish forage. Whether the parallel divergence in EOD is functionally related to this adaptation or solely serves as a prezygotic isolation mechanism remains to be elucidated.
KW  - ecological speciation
KW  - feeding behaviour
KW  - electric fish
KW  - trophic apparatus
KW  - evolutionary ecology
Y1  - 2020
U6  - https://doi.org/10.1007/s10682-020-10043-3
SN  - 0269-7653
SN  - 1573-8477
VL  - 34
IS  - 3
SP  - 427
EP  - 437
PB  - Springer Science
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Angelopoulos, Michael
A1  - Overduin, Pier Paul
A1  - Westermann, Sebastian
A1  - Tronicke, Jens
A1  - Strauss, Jens
A1  - Schirrmeister, Lutz
A1  - Biskaborn, Boris
A1  - Liebner, Susanne
A1  - Maksimov, Georgii
A1  - Grigoriev, Mikhail N.
A1  - Grosse, Guido
T1  - Thermokarst lake to lagoon transitions in Eastern Siberia
BT  - do submerged taliks refreeze?
JF  - Journal of geophysical research : Earth surface
N2  - As the Arctic coast erodes, it drains thermokarst lakes, transforming them into lagoons, and, eventually, integrates them into subsea permafrost. Lagoons represent the first stage of a thermokarst lake transition to a marine setting and possibly more saline and colder upper boundary conditions. In this research, borehole data, electrical resistivity surveying, and modeling of heat and salt diffusion were carried out at Polar Fox Lagoon on the Bykovsky Peninsula, Siberia. Polar Fox Lagoon is a seasonally isolated water body connected to Tiksi Bay through a channel, leading to hypersaline waters under the ice cover. The boreholes in the center of the lagoon revealed floating ice and a saline cryotic bed underlain by a saline cryotic talik, a thin ice-bearing permafrost layer, and unfrozen ground. The bathymetry showed that most of the lagoon had bedfast ice in spring. In bedfast ice areas, the electrical resistivity profiles suggested that an unfrozen saline layer was underlain by a thick layer of refrozen talik. The modeling showed that thermokarst lake taliks can refreeze when submerged in saltwater with mean annual bottom water temperatures below or slightly above 0 degrees C. This occurs, because the top-down chemical degradation of newly formed ice-bearing permafrost is slower than the refreezing of the talik. Hence, lagoons may precondition taliks with a layer of ice-bearing permafrost before encroachment by the sea, and this frozen layer may act as a cap on gas migration out of the underlying talik.
KW  - thermokarst lake
KW  - talik
KW  - lagoon
KW  - subsea permafrost
KW  - salt diffusion
KW  - Siberia
Y1  - 2020
U6  - https://doi.org/10.1029/2019JF005424
SN  - 2169-9003
SN  - 2169-9011
VL  - 125
IS  - 10
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Apanasewicz, Anna
A1  - Groth, Detlef
A1  - Scheffler, Christiane
A1  - Hermanussen, Michael
A1  - Piosek, Magdalena
A1  - Wychowaniec, Patrycja
A1  - Babiszewska, Magdalena
A1  - Barbarska, Olga
A1  - Ziomkiewicz, Anna
T1  - Traumatized women’s infants are bigger than children of mothers without traumas
JF  - Journal of biological and clinical anthropology : Anthropologischer Anzeiger
N2  - Life history theory predicts that experiencing stress during the early period of life will result in accelerated growth and earlier maturation. Indeed, animal and some human studies documented a faster pace of growth in the offspring of stressed mothers. Recent advances in epigenetics suggest that the effects of early developmental stress might be passed across the generations. However, evidence for such intergenerational transmission is scarce, at least in humans. Here we report the results of the study investigating the association between childhood trauma in mothers and physical growth in their children during the first months of life. Anthropometric and psychological data were collected from 99 mothers and their exclusively breastfed children at the age of 5 months. The mothers completed the Early Life Stress Questionnaire to assess childhood trauma. The questionnaire includes questions about the most traumatic events that they had experienced before the age of 12 years. Infant growth was evaluated based on the anthropometric measurements of weight, length, and head circumference. Also, to control for the size of maternal investment, the composition of breast milk samples taken at the time of infant anthropometric measurements was investigated. The children of mothers with higher early life stress tended to have higher weight and bigger head circumference. The association between infant anthropometrics and early maternal stress was not affected by breast milk composition, suggesting that the effect of maternal stress on infant growth was independent of the size of maternal investment. Our results demonstrate that early maternal trauma may affect the pace of growth in the offspring and, in consequence, lead to a faster life history strategy. This effect might be explained via changes in offspring epigenetics.
KW  - maternal trauma
KW  - early life trauma
KW  - breastfed infant development
KW  - POLS
Y1  - 2020
U6  - https://doi.org/10.1127/anthranz/2020/1285
SN  - 0003-5548
SN  - 2363-7099
VL  - 77
IS  - 5
SP  - 359
EP  - 374
PB  - Schweizerbart science publishers
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Apriyanto, Ardha
A1  - Tambunan, Van Basten
T1  - The complete mitochondrial genome of oil palm pollinating weevil, Elaeidobius kamerunicus Faust
BT  - (Coleoptera : Curculionidae)
JF  - Mitochondrial DNA: Part B
N2  - Elaeidobius kamerunicusis the most important insect pollinator in oil palm plantations. In this study, the mitochondrial genome (mitogenome) ofE. kamerunicus(17.729 bp), a member of the Curculionidae family, will be reported. The mitogenome consisted of 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), 2 ribosomal RNA genes (rRNAs), and a putative control region (CR). Phylogenetic analysis based on 13 protein-coding genes (PCGs) using maximum Likelihood (ML) methods indicated thatE. kamerunicusbelongs to the Curculionidae family. This mitochondrial genome provides essential information for understanding genetic populations, phylogenetics, molecular evolution, and other biological applications in this species.
KW  - Mitogenome
KW  - oil palm
KW  - pollinator
KW  - phylogeny
KW  - weevil
Y1  - 2020
U6  - https://doi.org/10.1080/23802359.2020.1823899
SN  - 2380-2359
VL  - 5
IS  - 3
SP  - 3450
EP  - 3452
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Arazi, Hamid
A1  - Asadi, Abbas
A1  - Khalkhali, Farhood
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players
BT  - A Preliminary Study
N2  - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r²) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
KW  - training load
KW  - rate of perceived exertion
KW  - rolling averages
KW  - weighted moving averages
KW  - football
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00608
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Arazi, Hamid
A1  - Asadi, Abbas
A1  - Khalkhali, Farhood
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players
BT  - A Preliminary Study
JF  - Frontiers in Physiology
N2  - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r 2) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
KW  - training load
KW  - rate of perceived exertion
KW  - rolling averages
KW  - weighted moving averages
KW  - football
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00995
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Arnold, Patrick
T1  - Evolution of the mammalian neck from developmental, morpho-functional, and paleontological perspectives
JF  - Journal of Mammalian Evolution
N2  - The mammalian neck adopts a variety of postures during daily life and generates numerous head trajectories. Despite its functional diversity, the neck is constrained to seven cervical vertebrae in (almost) all mammals. Given this low number, an unexpectedly high degree of modularity of the mammalian neck has more recently been uncovered. This work aims to review neck modularity in mammals from a developmental, morpho-functional, and paleontological perspective and how high functional diversity evolved in the mammalian neck after the occurrence of meristic limitations. The fixed number of cervical vertebrae and the developmental modularity of the mammalian neck are closely linked to anterior Hox genes expression and strong developmental integration between the neck and other body regions. In addition, basic neck biomechanics promote morpho-functional modularity due to preferred motion axes in the cranio-cervical and cervico-thoracic junction. These developmental and biomechanical determinants result in the characteristic and highly conserved shape variation among the vertebrae that delimits morphological modules. The step-wise acquisition of these unique cervical traits can be traced in the fossil record. The increasing functional specialization of neck modules, however, did not evolve all at once but started much earlier in the upper than in the lower neck. Overall, the strongly conserved modularity in the mammalian neck represents an evolutionary trade-off between the meristic constraints and functional diversity. Although a morpho-functional partition of the neck is common among amniotes, the degree of modularity and the way neck disparity is realized is unique in mammals.
KW  - cervical spine
KW  - modularity
KW  - developmental constraints
KW  - mammalian body
KW  - plan
KW  - neck evolution
Y1  - 2020
U6  - https://doi.org/10.1007/s10914-020-09506-9
SN  - 1064-7554
SN  - 1573-7055
VL  - 28
IS  - 2
SP  - 173
EP  - 183
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Arnous, Ahmad
A1  - Zeckra, Martin
A1  - Venerdini, Agostina
A1  - Alvarado, Patricia
A1  - Arrowsmith, Ramón
A1  - Guillemoteau, Julien
A1  - Landgraf, Angela
A1  - Gutiérrez, Adolfo Antonio
A1  - Strecker, Manfred
T1  - Neotectonic Activity in the Low-Strain Broken Foreland (Santa Bárbara System) of the North-Western Argentinean Andes (26°S)
JF  - Lithosphere
N2  - Uplift in the broken Andean foreland of the Argentine Santa Bárbara System (SBS) is associated with the contractional reactivation of basement anisotropies, similar to those reported from the thick-skinned Cretaceous-Eocene Laramide province of North America. Fault scarps, deformed Quaternary deposits and landforms, disrupted drainage patterns, and medium-sized earthquakes within the SBS suggest that movement along these structures may be a recurring phenomenon, with yet to be defined repeat intervals and rupture lengths. In contrast to the Subandes thrust belt farther north, where eastward-migrating deformation has generated a well-defined thrust front, the SBS records spatiotemporally disparate deformation along structures that are only known to the first order. We present herein the results of geomorphic desktop analyses, structural field observations, and 2D electrical resistivity tomography and seismic-refraction tomography surveys and an interpretation of seismic reflection profiles across suspected fault scarps in the sedimentary basins adjacent to the Candelaria Range (CR) basement uplift, in the south-central part of the SBS. Our analysis in the CR piedmont areas reveals consistency between the results of near-surface electrical resistivity and seismic-refraction tomography surveys, the locations of prominent fault scarps, and structural geometries at greater depth imaged by seismic reflection data. We suggest that this deformation is driven by deep-seated blind thrusting beneath the CR and associated regional warping, while shortening involving Mesozoic and Cenozoic sedimentary strata in the adjacent basins was accommodated by layer-parallel folding and flexural-slip faults that cut through Quaternary landforms and deposits at the surface.
Y1  - 2019
U6  - https://doi.org/10.2113/2020/8888588
SN  - 1947-4253
SN  - 1941-8264
VL  - 2020
IS  - 1
SP  - 1
EP  - 25
PB  - GSA
CY  - Boulder, Colo.
ER  - 
TY  - JOUR
A1  - Arya, Pooja
A1  - Feldmann, David
A1  - Kopyshev, Alexey
A1  - Lomadze, Nino
A1  - Santer, Svetlana
T1  - Light driven guided and self-organized motion of mesoporous colloidal particles
JF  - Soft matter
N2  - We report on guided and self-organized motion of ensembles of mesoporous colloidal particles that can undergo dynamic aggregation or separation upon exposure to light. The forces on particles involve the phenomenon of light-driven diffusioosmosis (LDDO) and are hydrodynamic in nature. They can be made to act passively on the ensemble as a whole but also used to establish a mutual interaction between particles. The latter scenario requires a porous colloid morphology such that the particle can act as a source or sink of a photosensitive surfactant, which drives the LDDO process. The interplay between the two modes of operation leads to fascinating possibilities of dynamical organization and manipulation of colloidal ensembles adsorbed at solid-liquid interfaces. While the passive mode can be thought of to allow for a coarse structuring of a cloud of colloids, the inter-particle mode may be used to impose a fine structure on a 2D particle grid. Local flow is used to impose and tailor interparticle interactions allowing for much larger interaction distances that can be achieved with, e.g., DLVO type of forces, and is much more versatile.
Y1  - 2019
U6  - https://doi.org/10.1039/c9sm02068c
SN  - 1744-683X
SN  - 1744-6848
VL  - 16
IS  - 5
SP  - 1148
EP  - 1155
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Arya, Pooja
A1  - Jelken, Joachim
A1  - Feldmann, David
A1  - Lomadze, Nino
A1  - Santer, Svetlana
T1  - Light driven diffusioosmotic repulsion and attraction of colloidal particles
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - In this paper, we introduce the phenomenon of light driven diffusioosmotic long-range attraction and repulsion of porous particles under irradiation with UV light. The change in the inter-particle interaction potential is governed by flow patterns generated around single colloids and results in reversible aggregation or separation of the mesoporous silica particles that are trapped at a solid surface. The range of the interaction potential extends to several times the diameter of the particle and can be adjusted by varying the light intensity. The "fuel" of the process is a photosensitive surfactant undergoing photo-isomerization from a more hydrophobic trans-state to a rather hydrophilic cis-state. The surfactant has different adsorption affinities to the particles depending on the isomerization state. The trans-isomer, for example, tends to accumulate in the negatively charged pores of the particles, while the cis-isomer prefers to remain in the solution. This implies that when under UV irradiation cis-isomers are being formed within the pores, they tend to diffuse out readily and generate an excess concentration near the colloid's outer surface, ultimately resulting in the initiation of diffusioosmotic flow. The direction of the flow depends strongly on the dynamic redistribution of the fraction of trans- and cis-isomers near the colloids due to different kinetics of photo-isomerization within the pores as compared to the bulk. The unique feature of the mechanism discussed in the paper is that the long-range mutual repulsion but also the attraction can be tuned by convenient external optical stimuli such as intensity so that a broad variety of experimental situations for manipulation of a particle ensemble can be realized.
Y1  - 2020
U6  - https://doi.org/10.1063/5.0007556
SN  - 0021-9606
SN  - 1089-7690
VL  - 152
IS  - 19
PB  - American Institute of Physics
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Arya, Pooja
A1  - Jelken, Joachim
A1  - Lomadze, Nino
A1  - Santer, Svetlana
A1  - Bekir, Marek
T1  - Kinetics of photo-isomerization of azobenzene containing surfactants
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistry
N2  - We report on photoisomerization kinetics of azobenzene containing surfactants in aqueous solution. The surfactant molecule consists of a positively charged trimethylammonium bromide head group, a hydrophobic spacer connecting via 6 to 10 CH2 groups to the azobenzene unit, and the hydrophobic tail of 1 and 3CH(2) groups. Under exposure to light, the azobenzene photoisomerizes from more stable trans- to metastable cis-state, which can be switched back either thermally in dark or by illumination with light of a longer wavelength. The surfactant isomerization is described by a kinetic model of a pseudo first order reaction approaching equilibrium, where the intensity controls the rate of isomerization until the equilibrated state. The rate constants of the trans-cis and cis-trans photoisomerization are calculated as a function of several parameters such as wavelength and intensity of light, the surfactant concentration, and the length of the hydrophobic tail. The thermal relaxation rate from cis- to trans-state is studied as well. The surfactant isomerization shows a different kinetic below and above the critical micellar concentration of the trans isomer due to steric hindrance within the densely packed micelle but does not depend on the spacer length.
KW  - genomic DNA conformation
KW  - water-interface
KW  - light photocontrol
KW  - driven
KW  - manipulation
KW  - photoisomerization
KW  - molecules
Y1  - 2020
U6  - https://doi.org/10.1063/1.5135913
SN  - 0021-9606
SN  - 1089-7690
VL  - 152
IS  - 2
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Assagra, Yuri A.O.
A1  - Altafim, Ruy Alberto Pisani
A1  - do Carmo, Joao P.
A1  - Altafim, Ruy A.C.
A1  - Rychkov, Dmitry
A1  - Wirges, Werner
A1  - Gerhard, Reimund
T1  - A new route to piezo-polymer transducers: 3D printing of polypropylene ferroelectrets
JF  - IEEE transactions on dielectrics and electrical insulation
N2  - Here, a promising approach for producing piezo-polymer transducers in a one-step process is presented. Using 3D-printing technology and polypropylene (PP) filaments, we are able to print a two-layered film structure with regular cavities of precisely controlled size and shape. It is found that the 3D-printed samples exhibit piezoelectric coefficients up to 200 pC/N, similar to those of other PP ferroelectrets, and their temporal and thermal behavior is in good agreement with those known of PP ferroelectrets. The piezoelectric response strongly decreases for applied pressures above 20 kPa, as the pressure in the air-filled cavities strongly influences the overall elastic modulus of ferroelectrets.
KW  - 3D printing
KW  - polymer ferroelectrets
KW  - sensors and actuators
KW  - piezoelectrets
KW  - electret polymers
KW  - soft electro-active materials
KW  - functional materials
KW  - soft matter
Y1  - 2020
U6  - https://doi.org/10.1109/TDEI.2020.008461
SN  - 1070-9878
SN  - 1558-4135
VL  - 27
IS  - 5
SP  - 1668
EP  - 1674
PB  - Inst. of Electr. and Electronics Engineers
CY  - Piscataway
ER  - 
TY  - JOUR
A1  - Athare, Tushar Ramchandra
A1  - Pradhan, Prajal
A1  - Kropp, Jürgen
T1  - Environmental implications and socioeconomic characterisation of Indian diets
JF  - The science of the total environment
N2  - India is facing a double burden of malnourishment with co-existences of under- and over-nourishment. Various socioeconomic factors play an essential role in determining dietary choices. Agriculture is one of the major emitters of greenhouse gases (GHGs) in India, contributing 18% of total emissions. It also consumes freshwater and uses land significantly. We identify eleven Indian diets by applying k-means cluster analysis on latest data from the Indian household consumer expenditure survey. The diets vary in calorie intake [2289-3218 kcal/Consumer Unit (CU)/day] and dietary composition. Estimated embodied GHG emissions in the diets range from 1.36 to 3.62 kg CO2eq./CU/day, land footprint from 4 to 5.45 m(2)/CU/day, whereas water footprint varies from 2.13 to 2.97m(3)/CU/day. Indian diets deviate from a healthy reference diet either with too much or too little consumption of certain food groups. Overall, cereals, sugar, and dairy products intake are higher. In contrast, the consumption of fruits and vegetables, pulses, and nuts is lower than recommended. Our study contributes to deriving required polices for the sustainable transformation of food systems in India to eliminate malnourishment and to reduce the environmental implications of the food systems. (c) 2020 Elsevier B.V. All rights reserved.
KW  - Indian diets
KW  - GHG emissions
KW  - land and water footprint
KW  - healthy diets
KW  - socioeconomic factors
Y1  - 2020
U6  - https://doi.org/10.1016/j.scitotenv.2020.139881
SN  - 0048-9697
SN  - 1879-1026
VL  - 737
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Audretsch, David B.
A1  - Kritikos, Alexander
A1  - Schiersch, Alexander
T1  - Microfirms and innovation in the service sector
JF  - Small business economics
N2  - In the context of microfirms, this paper analyzes whether the link between the three aspects involving innovative activities—R&D, innovative output, and productivity—hold for knowledge-intensive services. With especially high start-up rates and the majority of employees in microfirms, knowledge-intensive services (KIS) have a starkly different profile from manufacturing. Results from our structural models indicate that KIS firms benefit from innovation activities through increased labor productivity with highly skilled employees being similarly important compared to R&D for creating innovation output in microfirms. Moreover, the firm size advantage of large firms found for manufacturing almost disappears in KIS, with start-ups and young firms having a higher probability of initiating innovation activities and of successfully turning knowledge into innovation output than mature firms.
KW  - microfirms
KW  - MSMEs
KW  - R&D
KW  - service sector
KW  - innovation
KW  - productivity
Y1  - 2020
U6  - https://doi.org/10.1007/s11187-020-00366-4
SN  - 0921-898X
SN  - 1573-0913
VL  - 55
IS  - 4
SP  - 997
EP  - 1018
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Austin, Gina
A1  - Bondü, Rebecca
A1  - Elsner, Birgit
T1  - Executive function, theory of mind, and conduct-problem symptoms in middle childhood
JF  - Frontiers in psychology
N2  - Studies show relations between executive function (EF), Theory of Mind (ToM), and conduct-problem (CP) symptoms. However, many studies have involved cross-sectional data, small clinical samples, pre-school children, and/or did not consider potential mediation effects. The present study examined the longitudinal relations between EF, ToM abilities, and CP symptoms in a population-based sample of 1,657 children between 6 and 11 years (T1: M = 8.3 years, T2: M = 9.1 years; 51.9% girls). We assessed EF skills and ToM abilities via computerized tasks at first measurement (T1), CP symptoms were rated via parent questionnaires at T1 and approximately 1 year later (T2). Structural-equation models showed a negative relation between T1 EF and T2 CP symptoms even when controlling for attention-deficit hyperactivity disorder (ADHD) symptoms and other variables. This relation was fully mediated by T1 ToM abilities. The study shows how children's abilities to control their thoughts and behaviors and to understand others' mental states interact in the development of CP symptoms.
KW  - executive functions
KW  - theory of mind
KW  - conduct-problem symptoms
KW  - middle
KW  - childhood
KW  - longitudinal
Y1  - 2020
U6  - https://doi.org/10.3389/fpsyg.2020.00539
SN  - 1664-1078
VL  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Avetisyan, Serine
A1  - Lago, Sol
A1  - Vasishth, Shravan
T1  - Does case marking affect agreement attraction in comprehension?
JF  - Journal of memory and language
N2  - Previous studies have suggested that distinctive case marking on noun phrases reduces attraction effects in production, i.e., the tendency to produce a verb that agrees with a nonsubject noun. An important open question is whether attraction effects are modulated by case information in sentence comprehension. To address this question, we conducted three attraction experiments in Armenian, a language with a rich and productive case system. The experiments showed clear attraction effects, and they also revealed an overall role of case marking such that participants showed faster response and reading times when the nouns in the sentence had different case. However, we found little indication that distinctive case marking modulated attraction effects. We present a theoretical proposal of how case and number information may be used differentially during agreement licensing in comprehension. More generally, this work sheds light on the nature of the retrieval cues deployed when completing morphosyntactic dependencies.
KW  - subject-verb agreement
KW  - attraction
KW  - Case
KW  - Eastern Armenian
KW  - cue-based
KW  - retrieval
KW  - comprehension
Y1  - 2020
U6  - https://doi.org/10.1016/j.jml.2020.104087
SN  - 0749-596X
SN  - 1096-0821
VL  - 112
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Awad, Emad
A1  - Metzler, Ralf
T1  - Crossover dynamics from superdiffusion to subdiffusion
BT  - models and solutions
JF  - Fractional calculus and applied analysis : an international journal for theory and applications
N2  - The Cattaneo or telegrapher's equation describes the crossover from initial ballistic to normal diffusion. Here we study and survey time-fractional generalisations of this equation that are shown to produce the crossover of the mean squared displacement from superdiffusion to subdiffusion. Conditional solutions are derived in terms of Fox H-functions and the dth-order moments as well as the diffusive flux of the different models are derived. Moreover, the concept of the distribution-like is proposed as an alternative to the probability density function.
KW  - Cattaneo equation
KW  - telegrapher's equation
KW  - crossover dynamics
KW  - fractional dynamic equations
KW  - anomalous diffusion
KW  - superdiffusion and
KW  - subdiffusion
KW  - Fox H-functions
Y1  - 2020
U6  - https://doi.org/10.1515/fca-2020-0003
SN  - 1311-0454
SN  - 1314-2224
VL  - 23
IS  - 1
SP  - 55
EP  - 102
PB  - De Gruyter
CY  - Berlin ; Boston
ER  - 
TY  - JOUR
A1  - Ay-Bryson, Destina Sevde
A1  - Weck, Florian
A1  - Heinze, Peter Eric
A1  - Lang, Thomas
A1  - Kühne, Franziska
T1  - Can psychotherapy trainees distinguish standardized patients from real patients?
T1  - Können Psychotherapeut*innen in Ausbildung standardisierte Patient*innen von realen Patient*innen unterscheiden?
BT  - a pilot study
BT  - Ergebnisse einer Pilotstudie
JF  - Zeitschrift für Klinische Psychologie und Psychotherapie
N2  - Background:
Under the new psychotherapy law in Germany, standardized patients (SPs) are to become a standard component inpsychotherapy training, even though little is known about their authenticity.Objective:The present pilot study explored whether, followingan exhaustive two-day SP training, psychotherapy trainees can distinguish SPs from real patients.

Methods:
Twenty-eight psychotherapytrainees (M= 28.54 years of age,SD= 3.19) participated as blind raters. They evaluated six video-recorded therapy segments of trained SPsand real patients using the Authenticity of Patient Demonstrations Scale.

Results:
The authenticity scores of real patients and SPs did notdiffer (p= .43). The descriptive results indicated that the highest score of authenticity was given to an SP. Further, the real patients did notdiffer significantly from the SPs concerning perceived impairment (p= .33) and the likelihood of being a real patient (p= .52).

Conclusions:
The current results suggest that psychotherapy trainees were unable to distinguish the SPs from real patients. We therefore stronglyrecommend incorporating training SPs before application. Limitations and future research directions are discussed.
N2  - Theoretischer Hintergrund:
Mit dem neu eingeführten Direktstudium für zukünftige Psychotherapeut_innen (PiA) wirdder Einsatz von standardisierten Patient_innen (SP) in der Lehre zunehmen, obwohl die Authentizität der Rollendarstellungen durch SPempirisch bislang kaum untersucht wurde. Ziel der vorliegenden Studie war es daher zu untersuchen, ob SP trainiert werden können, dassPsychotherapeut_innen in Ausbildung (PiA) SP von realen Patient_innen nicht unterscheiden können.

Methode:
Insgesamt nahmen 28 PiA(M= 28.54 Jahre,SD= 3.19) als verblindete Rater teil. Sie haben sechs Therapiesitzungen von trainierten SP und realen Patient_innen mitder Skala Authentizität von Patientendarstellungen bewertet.

Ergebnisse:
Die Authentizitätswerte von SP unterschieden sich nicht signifi-kant von realen Patient_innen (p= .43). Deskriptive Ergebnisse legen nahe, dass ein SP im Schnitt am authentischsten bewertet wurde.Darüber hinaus unterschieden sich SP und reale Patient_innen nicht hinsichtlich der wahrgenommenen Beeinträchtigung (p= .33) sowie derWahrscheinlichkeit, als reale/r Patient_in bewertet zu werden (p= .52).

Fazit:
Die vorliegenden Ergebnisse legen nahe, dass PiA SP vonrealen Patient_innen nicht unterscheiden konnten. Daher legen wir ein ausführliches Training der SP nahe, bevor sie für Studium und Lehreeingesetzt werden. Die Limitationen sowie zukünftige Forschungsideen werden diskutiert.
KW  - evidence-based training
KW  - learning
KW  - simulated patients
KW  - simulation-based
KW  - education
KW  - therapist competence
KW  - evidenzbasiertes Training
KW  - Lernen
KW  - Simulationspatient_innen
KW  - simulationsbasierte Lehre
KW  - therapeutische
KW  - Kompetenz
Y1  - 2020
U6  - https://doi.org/10.1026/1616-3443/a000594
SN  - 1616-3443
SN  - 2190-6297
VL  - 49
IS  - 3
SP  - 182
EP  - 190
PB  - Hogrefe
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Ayzel, Georgy
A1  - Scheffer, Tobias
A1  - Heistermann, Maik
T1  - RainNet v1.0
BT  - a convolutional neural network for radar-based precipitation nowcasting
JF  - Geoscientific Model Development
N2  - In this study, we present RainNet, a deep convolutional neural network for radar-based precipitation nowcasting. Its design was inspired by the U-Net and SegNet families of deep learning models, which were originally designed for binary segmentation tasks. RainNet was trained to predict continuous precipitation intensities at a lead time of 5min, using several years of quality-controlled weather radar composites provided by the German Weather Service (DWD). That data set covers Germany with a spatial domain of 900km × 900km and has a resolution of 1km in space and 5min in time. Independent verification experiments were carried out on 11 summer precipitation events from 2016 to 2017. In order to achieve a lead time of 1h, a recursive approach was implemented by using RainNet predictions at 5min lead times as model inputs for longer lead times. In the verification experiments, trivial Eulerian persistence and a conventional model based on optical flow served as benchmarks. The latter is available in the rainymotion library and had previously been shown to outperform DWD's operational nowcasting model for the same set of verification events.

RainNet significantly outperforms the benchmark models at all lead times up to 60min for the routine verification metrics mean absolute error (MAE) and the critical success index (CSI) at intensity thresholds of 0.125, 1, and 5mm h⁻¹. However, rainymotion turned out to be superior in predicting the exceedance of higher intensity thresholds (here 10 and 15mm h⁻¹). The limited ability of RainNet to predict heavy rainfall intensities is an undesirable property which we attribute to a high level of spatial smoothing introduced by the model. At a lead time of 5min, an analysis of power spectral density confirmed a significant loss of spectral power at length scales of 16km and below. Obviously, RainNet had learned an optimal level of smoothing to produce a nowcast at 5min lead time. In that sense, the loss of spectral power at small scales is informative, too, as it reflects the limits of predictability as a function of spatial scale. Beyond the lead time of 5min, however, the increasing level of smoothing is a mere artifact – an analogue to numerical diffusion – that is not a property of RainNet itself but of its recursive application. In the context of early warning, the smoothing is particularly unfavorable since pronounced features of intense precipitation tend to get lost over longer lead times. Hence, we propose several options to address this issue in prospective research, including an adjustment of the loss function for model training, model training for longer lead times, and the prediction of threshold exceedance in terms of a binary segmentation task. Furthermore, we suggest additional input data that could help to better identify situations with imminent precipitation dynamics. The model code, pretrained weights, and training data are provided in open repositories as an input for such future studies.
KW  - weather
KW  - models
KW  - skill
Y1  - 2020
U6  - https://doi.org/10.5194/gmd-13-2631-2020
SN  - 1991-959X
SN  - 1991-9603
VL  - 13
IS  - 6
SP  - 2631
EP  - 2644
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Azadian, Elaheh
A1  - Majlesi, Mahdi
A1  - Jafarnezhadgero, Amir Ali
A1  - Granacher, Urs
T1  - The impact of hearing loss on three-dimensional lower limb joint torques during walking in prepubertal boys
JF  - Journal of bodywork and movement therapies
N2  - Introduction:
In children, the impact of hearing loss on biomechanical gait parameters is not well understood. Thus, the objectives of this study were to examine three-dimensional lower limb joint torques in deaf compared to age-matched healthy (hearing) children while walking at preferred gait speed.

Methods: 
Thirty prepubertal boys aged 8-14 were enrolled in this study and divided into a group with hearing loss (deaf group) and an age-matched healthy control. Three-dimensional joint torques were analyzed during barefoot walking at preferred speed using Kistler force plates and a Vicon motion capture system. 

Results: 
Findings revealed that boys with hearing loss showed lower joint torques in ankle evertors, knee flexors, abductors and internal rotators as well as in hip internal rotators in both, the dominant and non-dominant lower limbs (all p < 0.05; d = 1.23-7.00; 14-79%). Further, in the dominant limb, larger peak ankle dorsiflexor (p < 0.001; d = 1.83; 129%), knee adductor (p < 0.001; d = 3.20; 800%), and hip adductor torques (p < 0.001; d = 2.62; 350%) were found in deaf participants compared with controls. 

Conclusion: 
The observed altered lower limb torques during walking are indicative of unstable gait in children with hearing loss. More research is needed to elucidate whether physical training (e.g., balance and/or gait training) has the potential to improve walking performance in this patient group. (C) 2019 Elsevier Ltd. All rights reserved.
KW  - torque
KW  - hearing loss
KW  - gait
KW  - dominant limb
KW  - non-dominant limb
Y1  - 2020
U6  - https://doi.org/10.1016/j.jbmt.2019.10.013
SN  - 1360-8592
SN  - 1532-9283
VL  - 24
IS  - 2
SP  - 123
EP  - 129
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Azzali, Sara
A1  - Paycha, Sylvie
T1  - Spectral zeta-invariants lifted to coverings
JF  - Transactions of the American Mathematical Society
N2  - The canonical trace and the Wodzicki residue on classical pseudo-differential operators on a closed manifold are characterised by their locality and shown to be preserved under lifting to the universal covering as a result of their local feature. As a consequence, we lift a class of spectral zeta-invariants using lifted defect formulae which express discrepancies of zeta-regularised traces in terms of Wodzicki residues. We derive Atiyah's L-2-index theorem as an instance of the Z(2)-graded generalisation of the canonical lift of spectral zeta-invariants and we show that certain lifted spectral zeta-invariants for geometric operators are integrals of Pontryagin and Chern forms.
Y1  - 2020
U6  - https://doi.org/10.1090/tran/8067
SN  - 0002-9947
SN  - 1088-6850
VL  - 373
IS  - 9
SP  - 6185
EP  - 6226
PB  - American Mathematical Society
CY  - Providence, RI
ER  - 
TY  - JOUR
A1  - Backhaus, Daniel
A1  - Engbert, Ralf
A1  - Rothkegel, Lars Oliver Martin
A1  - Trukenbrod, Hans Arne
T1  - Task-dependence in scene perception: Head unrestrained viewing using mobile eye-tracking
JF  - Journal of vision
N2  - Real-world scene perception is typically studied in the laboratory using static picture viewing with restrained head position. Consequently, the transfer of results obtained in this paradigm to real-word scenarios has been questioned. The advancement of mobile eye-trackers and the progress in image processing, however, permit a more natural experimental setup that, at the same time, maintains the high experimental control from the standard laboratory setting. We investigated eye movements while participants were standing in front of a projector screen and explored images under four specific task instructions. Eye movements were recorded with a mobile eye-tracking device and raw gaze data were transformed from head-centered into image-centered coordinates. We observed differences between tasks in temporal and spatial eye-movement parameters and found that the bias to fixate images near the center differed between tasks. Our results demonstrate that current mobile eye-tracking technology and a highly controlled design support the study of fine-scaled task dependencies in an experimental setting that permits more natural viewing behavior than the static picture viewing paradigm.
KW  - scene viewing
KW  - real-world scenarios
KW  - mobile eye-tracking
KW  - task
KW  - influence
KW  - central fixation bias
Y1  - 2020
U6  - https://doi.org/10.1167/jov.20.5.3
SN  - 1534-7362
VL  - 20
IS  - 5
SP  - 1
EP  - 21
PB  - Association for Research in Vision and Opthalmology
CY  - Rockville
ER  - 
TY  - JOUR
A1  - Baerenzung, Julien
A1  - Holschneider, Matthias
A1  - Wicht, Johannes
A1  - Lesur, Vincent
A1  - Sanchez, Sabrina
T1  - The Kalmag model as a candidate for IGRF-13
JF  - Earth, planets and space
N2  - We present a new model of the geomagnetic field spanning the last 20 years and called Kalmag. Deriving from the assimilation of CHAMP and Swarm vector field measurements, it separates the different contributions to the observable field through parameterized prior covariance matrices. To make the inverse problem numerically feasible, it has been sequentialized in time through the combination of a Kalman filter and a smoothing algorithm. The model provides reliable estimates of past, present and future mean fields and associated uncertainties. The version presented here is an update of our IGRF candidates; the amount of assimilated data has been doubled and the considered time window has been extended from [2000.5, 2019.74] to [2000.5, 2020.33].
KW  - Geomagnetic field
KW  - Secular variation
KW  - Assimilation
KW  - Kalman filter
KW  - Machine learning
Y1  - 2020
U6  - https://doi.org/10.1186/s40623-020-01295-y
SN  - 1880-5981
VL  - 72
IS  - 1
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Baes, Marzieh
A1  - Sobolev, Stephan
A1  - Gerya, Taras V.
A1  - Brune, Sascha
T1  - Plume-induced subduction initiation
BT  - single-slab or multi-slab subduction?
JF  - Geochemistry, geophysics, geosystems
N2  - Initiation of subduction following the impingement of a hot buoyant mantle plume is one of the few scenarios that allow breaking the lithosphere and recycling a stagnant lid without requiring any preexisting weak zones. Here, we investigate factors controlling the number and shape of retreating subducting slabs formed by plume-lithosphere interaction. Using 3-D thermomechanical models we show that the deformation regime, which defines formation of single-slab or multi-slab subduction, depends on several parameters such as age of oceanic lithosphere, thickness of the crust and large-scale lithospheric extension rate. Our model results indicate that on present-day Earth multi-slab plume-induced subduction is initiated only if the oceanic lithosphere is relatively young (<30-40 Myr, but >10 Myr), and the crust has a typical thickness of 8 km. In turn, development of single-slab subduction is facilitated by older lithosphere and pre-imposed extensional stresses. In early Earth, plume-lithosphere interaction could have led to formation of either episodic short-lived circular subduction when the oceanic lithosphere was young or to multi-slab subduction when the lithosphere was old.
KW  - subduction zone
KW  - plume
KW  - numerical model
KW  - singleslab
KW  - multi-slab
Y1  - 2020
U6  - https://doi.org/10.1029/2019GC008663
SN  - 1525-2027
VL  - 21
IS  - 2
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Baes, Marzieh
A1  - Sobolev, Stephan V.
A1  - Gerya, Taras V.
A1  - Brune, Sascha
T1  - Subduction initiation by Plume-Plateau interaction
BT  - insights from numerical models
JF  - Geochemistry, geophysics, geosystems
N2  - It has recently been demonstrated that the interaction of a mantle plume with sufficiently old oceanic lithosphere can initiate subduction. However, the existence of large lithospheric heterogeneities, such as a buoyant plateau, in proximity to a rising plume head may potentially hinder the formation of a new subduction zone. Here, we investigate this scenario by means of 3-D numerical thermomechanical modeling. We explore how plume-lithosphere interaction is affected by lithospheric age, relative location of plume head and plateau border, and the strength of the oceanic crust. Our numerical experiments suggest four different geodynamic regimes: (a) oceanic trench formation, (b) circular oceanic-plateau trench formation, (c) plateau trench formation, and (d) no trench formation. We show that regardless of the age and crustal strength of the oceanic lithosphere, subduction can initiate when the plume head is either below the plateau border or at a distance less than the plume radius from the plateau edge. Crustal heterogeneity facilitates subduction initiation of old oceanic lithosphere. High crustal strength hampers the formation of a new subduction zone when the plume head is located below a young lithosphere containing a thick and strong plateau. We suggest that plume-plateau interaction in the western margin of the Caribbean could have resulted in subduction initiation when the plume head impinged onto the oceanic lithosphere close to the border between plateau and oceanic crust.
KW  - subduction zone
KW  - plume
KW  - plateau
KW  - numerical modeling
KW  - plume-induced
KW  - subduction initiation (PISI)
Y1  - 2020
U6  - https://doi.org/10.1029/2020GC009119
SN  - 1525-2027
VL  - 21
IS  - 8
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Bahr, André
A1  - Kolber, Gilles
A1  - Kaboth-Bahr, Stefanie
A1  - Reinhardt, Lutz
A1  - Friedrich, Oliver
A1  - Pross, Jörg
T1  - Mega-monsoon variability during the late Triassic
BT  - re-assessing the role of orbital forcing in the deposition of playa sediments in the Germanic Basin
JF  - Sedimentology : the journal of the International Association of Sedimentologists
N2  - The formation of the supercontinent Pangaea during the Permo-Triassic gave rise to an extreme monsoonal climate (often termed 'mega-monsoon') that has been documented by numerous palaeo-records. However, considerable debate exists about the role of orbital forcing in causing humid intervals in an otherwise arid climate. To shed new light on the forcing of monsoonal variability in subtropical Pangaea, this study focuses on sediment facies and colour variability of playa and alluvial fan deposits in an outcrop from the late Carnian (ca 225 Ma) in the southern Germanic Basin, south-western Germany. The sediments were deposited against a background of increasingly arid conditions following the humid Carnian Pluvial Event (ca 234 to 232 Ma). The ca 2 center dot 4 Myr long sedimentary succession studied shows a tripartite long-term evolution, starting with a distal mud-flat facies deposited under arid conditions. This phase was followed by a highly variable playa-lake environment that documents more humid conditions and finally a regression of the playa-lake due to a return of arid conditions. The red-green (a*) and lightness (L*) records show that this long-term variability was overprinted by alternating wet/dry cycles driven by orbital precession and ca 405 kyr eccentricity, without significant influence of obliquity. The absence of obliquity in this record indicates that high-latitude forcing played only a minor role in the southern Germanic Basin during the late Carnian. This is different from the subsequent Norian when high-latitude signals became more pronounced, potentially related to the northward drift of the Germanic Basin. The recurring pattern of pluvial events during the late Triassic demonstrates that orbital forcing, in particular eccentricity, stimulated the occurrence and intensity of wet phases. It also highlights the possibility that the Carnian Pluvial Event, although most likely triggered by enhanced volcanic activity, may also have been modified by an orbital stimulus.
KW  - Carnian Pluvial Event
KW  - Germanic Basin
KW  - Late Triassic
KW  - mega-monsoon
KW  - orbital forcing
KW  - playa-lake
Y1  - 2019
U6  - https://doi.org/10.1111/sed.12668
SN  - 0037-0746
SN  - 1365-3091
VL  - 67
IS  - 2
SP  - 951
EP  - 970
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Bakadorova, Olga
A1  - Lazarides, Rebecca
A1  - Raufelder, Diana
T1  - Effects of social and individual school self-concepts on school engagement during adolescence
JF  - European journal of psychology of education : a journal of education and development
N2  - While school self-concept is an important facilitator of a student's school engagement, previous studies rarely investigated whether it may also explain the change in students' school engagement during secondary school. Moreover, as social relations play an increasingly important role in adolescence, the current research distinguishes between the social and individual school self-concepts of a student. Whereas individual school self-concept uses the perception of a student's own ability in the past in order to estimate perceived current ability, social school self-concept refers to the comparison of a student's own perceived current ability with the current perceived abilities of others. We examined the role of students' individual and social school self-concepts in the development of behavioral and emotional school engagement during the period from grade 8 to grade 9. The sample consisted of 1088 German adolescents at the first measurement time (M-age = 13.70, SD = 0.53; 53.9% girls). The findings suggested a significant decline in both emotional and behavioral school engagement over the span of 1.5 years. In addition, social-but not individual-school self-concept was associated with the change in both dimensions of school engagement over time, such as it may intensify a student's decline in school engagement levels. This might be due to the fact that students with a high social school self-concept tend to increasingly emphasize competition and comparison and strive for high grades, which lowers students' school participation and identification in the long term.
KW  - Individual school self-concept
KW  - Social school self-concept
KW  - School
KW  - engagement
KW  - Adolescence
KW  - Latent change model
Y1  - 2019
U6  - https://doi.org/10.1007/s10212-019-00423-x
SN  - 0256-2928
SN  - 1878-5174
VL  - 35
IS  - 1
SP  - 73
EP  - 91
PB  - Springer Nature
CY  - Lisboa
ER  - 
TY  - JOUR
A1  - Bald, Ilko
A1  - Solov'yov, Ilia A.
A1  - Mason, Nigel J.
A1  - Solov'yov, Andrey V.
T1  - Special issue
BT  - dynamics of systems on the nanoscale (2018). Editorial
JF  - The European physical journal. D, Atomic, molecular, optical and plasma physics
N2  - The structure, formation and dynamics of both animate and inanimate matter on the nanoscale are a highly interdisciplinary field of rapidly emerging research engaging a broad community encompassing experimentalists, theorists, and technologists. It is relevant for a large variety of molecular and nanosystems of different origin and composition and concerns numerous phenomena originating from physics, chemistry, biology, or materials science. This Topical Issue presents a collection of original research papers devoted to different aspects of structure and dynamics on the nanoscale. Some of the contributions discuss specific applications of the research results in several modern technologies and in next generation medicine. Most of the works of this topical issue were reported at the Fifth International Conference on Dynamics of Systems on the Nanoscale (DySoN) - the premier forum for the presentation of cutting-edge research in this field that was held in Potsdam, Germany in October of 2018.
Y1  - 2020
U6  - https://doi.org/10.1140/epjd/e2020-10134-4
SN  - 1434-6060
SN  - 1434-6079
VL  - 74
IS  - 4
SP  - 75
EP  - 82
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Balischewski, Christian
A1  - Behrens, Karsten
A1  - Zehbe, Kerstin
A1  - Günter, Christina
A1  - Mies, Stefan
A1  - Sperlich, Eric
A1  - Kelling, Alexandra
A1  - Taubert, Andreas
T1  - Ionic liquids with more than one metal
BT  - optical and rlectrochemical properties versus d-block metal vombinations
JF  - Chemistry - a European journal
N2  - Thirteen N-butylpyridinium salts, including three monometallic [C4Py](2)[MCl4], nine bimetallic [C4Py](2)[(M1-xMxCl4)-M-a-Cl-b] and one trimetallic compound [C4Py](2)[(M1-y-zMyMz (c) Cl4)-M-a-M-b] (M=Co, Cu, Mn; x=0.25, 0.50 or 0.75 and y=z=0.33), were synthesized and their structure and thermal and electrochemical properties were studied. All compounds are ionic liquids (ILs) with melting points between 69 and 93 degrees C. X-ray diffraction proves that all ILs are isostructural. The conductivity at room temperature is between 10(-4) and 10(-8) S cm(-1). Some Cu-based ILs reach conductivities of 10(-2) S cm(-1), which is, however, probably due to IL dec. This correlates with the optical bandgap measurements indicating the formation of large bandgap semiconductors. At elevated temperatures approaching the melting points, the conductivities reach up to 1.47x10(-1) S cm(-1) at 70 degrees C. The electrochemical stability windows of the ILs are between 2.5 and 3.0 V.
KW  - bandgap
KW  - electrochemistry
KW  - ionic liquids
KW  - metal-containing ionic
KW  - liquids
KW  - tetrahalido metallates
Y1  - 2020
U6  - https://doi.org/10.1002/chem.202003097
SN  - 0947-6539
SN  - 1521-3765
VL  - 26
IS  - 72
SP  - 17504
EP  - 17513
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Balk, Maria
A1  - Behl, Marc
A1  - Lendlein, Andreas
T1  - Actuators based on oligo[(epsilon-caprolactone)-co-glycolide] with accelerated hydrolytic degradation
JF  - MRS advances : a journal of the Materials Research Society (MRS)
N2  - Polyester-based shape-memory polymer actuators are multifunctional materials providing reversible macroscopic shape shifts as well as hydrolytic degradability. Here, the function-function interdependencies (between shape shifts and degradation behaviour) will determine actuation performance and its life time. In this work, glycolide units were incorporated in poly(epsilon-caprolactone) based actuator materials in order to achieve an accelerated hydrolytic degradation and to explore the function-function relationship. Three different oligo[(epsilon-caprolactone)-co-glycolide] copolymers (OCGs) with similar molecular weights (10.5 +/- 0.5 kg center dot mol(-1)) including a glycolide content of 8, 16, and 26 mol% (ratio 1:1:1 wt%) terminated with methacrylated moieties were crosslinked. The obtained actuators provided a broad melting transition in the range from 27 to 44 degrees C. The hydrolytic degradation of programmed OCG actuators (200% of elongation) resulted in a reduction of sample mass to 51 wt% within 21 days at pH = 7.4 and 40 degrees C. Degradation results in a decrease of T-m associated to the actuating units and increasing T-m associated to the skeleton forming units. The actuation capability decreased almost linear as function of time. After 11 days of hydrolytic degradation the shape-memory functionality was lost. Accordingly, a fast degradation behaviour as required, e.g., for actuator materials intended as implant material can be realized.
KW  - actuation
KW  - shape memory
KW  - polymer
KW  - crystalline
Y1  - 2020
U6  - https://doi.org/10.1557/adv.2019.447
SN  - 2059-8521
VL  - 5
IS  - 12-13
SP  - 655
EP  - 666
PB  - Cambridge University Press
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Bandara, Lashi
A1  - Bryan, Paul
T1  - Heat kernels and regularity for rough metrics on smooth manifolds
JF  - Mathematische Nachrichten
N2  - We consider rough metrics on smooth manifolds and corresponding Laplacians induced by such metrics. We demonstrate that globally continuous heat kernels exist and are Holder continuous locally in space and time. This is done via local parabolic Harnack estimates for weak solutions of operators in divergence form with bounded measurable coefficients in weighted Sobolev spaces.
KW  - heat kernel
KW  - parabolic Harnack estimate
KW  - rough metrics
Y1  - 2020
U6  - https://doi.org/10.1002/mana.201800459
SN  - 0025-584X
SN  - 1522-2616
VL  - 293
IS  - 12
SP  - 2255
EP  - 2270
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Banerjee, Pallavi
A1  - Lipowsky, Reinhard
A1  - Santer, Mark
T1  - Coarse-grained molecular model for the Glycosylphosphatidylinositol anchor with and without protein
JF  - Journal of Chemical Theory and Computation
N2  - Glycosylphosphatidylinositol (GPI) anchors are a unique class of complex glycolipids that anchor a great variety of proteins to the extracellular leaflet of plasma membranes of eukaryotic cells. These anchors can exist either with or without an attached protein called GPI-anchored protein (GPI-AP) both in vitro and in vivo. Although GPIs are known to participate in a broad range of cellular functions, it is to a large extent unknown how these are related to GPI structure and composition. Their conformational flexibility and microheterogeneity make it difficult to study them experimentally. Simplified atomistic models are amenable to all-atom computer simulations in small lipid bilayer patches but not suitable for studying their partitioning and trafficking in complex and heterogeneous membranes. Here, we present a coarse-grained model of the GPI anchor constructed with a modified version of the MARTINI force field that is suited for modeling carbohydrates, proteins, and lipids in an aqueous environment using MARTINI's polarizable water. The nonbonded interactions for sugars were reparametrized by calculating their partitioning free energies between polar and apolar phases. In addition, sugar-sugar interactions were optimized by adjusting the second virial coefficients of osmotic pressures for solutions of glucose, sucrose, and trehalose to match with experimental data. With respect to the conformational dynamics of GPI-anchored green fluorescent protein, the accessible time scales are now at least an order of magnitude larger than for the all-atom system. This is particularly important for fine-tuning the mutual interactions of lipids, carbohydrates, and amino acids when comparing to experimental results. We discuss the prospective use of the coarse-grained GPI model for studying protein-sorting and trafficking in membrane models.
KW  - Martini force-field
KW  - osmotic-pressure
KW  - potential-functions
KW  - aqueous-solution
KW  - dynamics
KW  - coefficient
KW  - simulation
KW  - trypanosoma
KW  - transition
KW  - parameters
Y1  - 2020
U6  - https://doi.org/10.1021/acs.jctc.0c00056
SN  - 1549-9626
SN  - 1549-9618
VL  - 16
IS  - 6
PB  - ACS Publications
CY  - Washington DC
ER  - 
TY  - JOUR
A1  - Baritello, Omar
A1  - Khajooei, Mina
A1  - Engel, Tilman
A1  - Kopinski, Stephan
A1  - Quarmby, Andrew James
A1  - Müller, Steffen
A1  - Mayer, Frank
T1  - Neuromuscular shoulder activity during exercises with different combinations of stable and unstable weight mass
JF  - BMC sports science, medicine and rehabilitation
N2  - Background Recent shoulder injury prevention programs have utilized resistance exercises combined with different forms of instability, with the goal of eliciting functional adaptations and thereby reducing the risk of injury. However, it is still unknown how an unstable weight mass (UWM) affects the muscular activity of the shoulder stabilizers. Aim of the study was to assess neuromuscular activity of dynamic shoulder stabilizers under four conditions of stable and UWM during three shoulder exercises. It was hypothesized that a combined condition of weight with UWM would elicit greater activation due to the increased stabilization demand. Methods Sixteen participants (7 m/9 f) were included in this cross-sectional study and prepared with an EMG-setup for the: Mm. upper/lower trapezius (U.TA/L.TA), lateral deltoid (DE), latissimus dorsi (LD), serratus anterior (SA) and pectoralis major (PE). A maximal voluntary isometric contraction test (MVIC; 5 s.) was performed on an isokinetic dynamometer. Next, internal/external rotation (In/Ex), abduction/adduction (Ab/Ad) and diagonal flexion/extension (F/E) exercises (5 reps.) were performed with four custom-made-pipes representing different exercise conditions. First, the empty-pipe (P; 0.5 kg) and then, randomly ordered, water-filled-pipe (PW; 1 kg), weight-pipe (PG; 4.5 kg) and weight + water-filled-pipe (PWG; 4.5 kg), while EMG was recorded. Raw root-mean-square values (RMS) were normalized to MVIC (%MVIC). Differences between conditions for RMS%MVIC, scapular stabilizer (SR: U.TA/L.TA; U.TA/SA) and contraction (CR: concentric/eccentric) ratios were analyzed (paired t-test; p <= 0.05; Bonferroni adjusted alpha = 0.008). Results PWG showed significantly greater muscle activity for all exercises and all muscles except for PE compared to P and PW. Condition PG elicited muscular activity comparable to PWG (p > 0.008) with significantly lower activation of L.TA and SA in the In/Ex rotation. The SR ratio was significantly higher in PWG compared to P and PW. No significant differences were found for the CR ratio in all exercises and for all muscles. Conclusion Higher weight generated greater muscle activation whereas an UWM raised the neuromuscular activity, increasing the stabilization demands. Especially in the In/Ex rotation, an UWM increased the RMS%MVIC and SR ratio. This might improve training effects in shoulder prevention and rehabilitation programs.
KW  - EMG
KW  - instability
KW  - overhead athlete
KW  - unstable resistance training
KW  - water
KW  - pipe
KW  - rotator cuff
Y1  - 2020
U6  - https://doi.org/10.1186/s13102-020-00168-x
SN  - 2052-1847
VL  - 12
IS  - 1
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Barkow, Isolde S.
A1  - Oswald, Sascha
A1  - Lensing, Hermann Josef
A1  - Munz, Matthias
T1  - Seasonal dynamics modifies fate of oxygen, nitrate, and organic micropollutants during bank filtration
BT  - temperature-dependent reactive transport modeling of field data
JF  - Environmental science and pollution research : official organ of the EuCheMS Division for Chemistry and the Environment, EuCheMS DCE
N2  - Bank filtration is considered to improve water quality through microbially mediated degradation of pollutants and is suitable for waterworks to increase their production. In particular, aquifer temperatures and oxygen supply have a great impact on many microbial processes. To investigate the temporal and spatial behavior of selected organic micropollutants during bank filtration in dependence of relevant biogeochemical conditions, we have set up a 2D reactive transport model using MODFLOW and PHT3D under the user interface ORTI3D. The considered 160-m-long transect ranges from the surface water to a groundwater extraction well of the adjacent waterworks. For this purpose, water levels, temperatures, and chemical parameters were regularly measured in the surface water and groundwater observation wells over one and a half years. To simulate the effect of seasonal temperature variations on microbial mediated degradation, we applied an empirical temperature factor, which yields a strong reduction of the degradation rate at groundwater temperatures below 11 degrees C. Except for acesulfame, the considered organic micropollutants are substantially degraded along their subsurface flow paths with maximum degradation rates in the range of 10(-6) mol L-1 s(-1). Preferential biodegradation of phenazone, diclofenac, and valsartan was found under oxic conditions, whereas carbamazepine and sulfamethoxazole were degraded under anoxic conditions. This study highlights the influence of seasonal variations in oxygen supply and temperature on the fate of organic micropollutants in surface water infiltrating into an aquifer.
KW  - bank filtration
KW  - aerobic and anaerobic conditions
KW  - pharmaceuticals and
KW  - personal care products
KW  - reactive transport modeling
KW  - degradation
Y1  - 2020
U6  - https://doi.org/10.1007/s11356-020-11002-9
SN  - 0944-1344
SN  - 1614-7499
VL  - 28
IS  - 8
SP  - 9682
EP  - 9700
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Barkowsky, Matthias
A1  - Giese, Holger
T1  - Hybrid search plan generation for generalized graph pattern matching
JF  - Journal of logical and algebraic methods in programming
N2  - In recent years, the increased interest in application areas such as social networks has resulted in a rising popularity of graph-based approaches for storing and processing large amounts of interconnected data. To extract useful information from the growing network structures, efficient querying techniques are required.
In this paper, we propose an approach for graph pattern matching that allows a uniform handling of arbitrary constraints over the query vertices. Our technique builds on a previously introduced matching algorithm, which takes concrete host graph information into account to dynamically adapt the employed search plan during query execution. The dynamic algorithm is combined with an existing static approach for search plan generation, resulting in a hybrid technique which we further extend by a more sophisticated handling of filtering effects caused by constraint checks. We evaluate the presented concepts empirically based on an implementation for our graph pattern matching tool, the Story Diagram Interpreter, with queries and data provided by the LDBC Social Network Benchmark. Our results suggest that the hybrid technique may improve search efficiency in several cases, and rarely reduces efficiency.
KW  - graph pattern matching
KW  - search plan generation
Y1  - 2020
U6  - https://doi.org/10.1016/j.jlamp.2020.100563
SN  - 2352-2208
VL  - 114
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Barlow, Axel
A1  - Hartmann, Stefanie
A1  - Gonzalez, Javier
A1  - Hofreiter, Michael
A1  - Paijmans, Johanna L. A.
T1  - Consensify
BT  - a method for generating pseudohaploid genome sequences from palaeogenomic datasets with reduced error rates
JF  - Genes / Molecular Diversity Preservation International
N2  - A standard practise in palaeogenome analysis is the conversion of mapped short read data into pseudohaploid sequences, frequently by selecting a single high-quality nucleotide at random from the stack of mapped reads. This controls for biases due to differential sequencing coverage, but it does not control for differential rates and types of sequencing error, which are frequently large and variable in datasets obtained from ancient samples. These errors have the potential to distort phylogenetic and population clustering analyses, and to mislead tests of admixture using D statistics. We introduce Consensify, a method for generating pseudohaploid sequences, which controls for biases resulting from differential sequencing coverage while greatly reducing error rates. The error correction is derived directly from the data itself, without the requirement for additional genomic resources or simplifying assumptions such as contemporaneous sampling. For phylogenetic and population clustering analysis, we find that Consensify is less affected by artefacts than methods based on single read sampling. For D statistics, Consensify is more resistant to false positives and appears to be less affected by biases resulting from different laboratory protocols than other frequently used methods. Although Consensify is developed with palaeogenomic data in mind, it is applicable for any low to medium coverage short read datasets. We predict that Consensify will be a useful tool for future studies of palaeogenomes.
KW  - palaeogenomics
KW  - ancient DNA
KW  - sequencing error
KW  - error reduction
KW  - D statistics
KW  - bioinformatics
Y1  - 2020
U6  - https://doi.org/10.3390/genes11010050
SN  - 2073-4425
VL  - 11
IS  - 1
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Barnett, Ross
A1  - Westbury, Michael V.
A1  - Sandoval-Velasco, Marcela
A1  - Vieira, Filipe Garrett
A1  - Jeon, Sungwon
A1  - Zazula, Grant
A1  - Martin, Michael D.
A1  - Ho, Simon Y. W.
A1  - Mather, Niklas
A1  - Gopalakrishnan, Shyam
A1  - Ramos-Madrigal, Jazmin
A1  - de Manuel, Marc
A1  - Zepeda-Mendoza, M. Lisandra
A1  - Antunes, Agostinho
A1  - Baez, Aldo Carmona
A1  - De Cahsan, Binia
A1  - Larson, Greger
A1  - O'Brien, Stephen J.
A1  - Eizirik, Eduardo
A1  - Johnson, Warren E.
A1  - Koepfli, Klaus-Peter
A1  - Wilting, Andreas
A1  - Fickel, Jörns
A1  - Dalen, Love
A1  - Lorenzen, Eline D.
A1  - Marques-Bonet, Tomas
A1  - Hansen, Anders J.
A1  - Zhang, Guojie
A1  - Bhak, Jong
A1  - Yamaguchi, Nobuyuki
A1  - Gilbert, M. Thomas P.
T1  - Genomic adaptations and evolutionary history of the extinct scimitar-toothed cat
BT  - Homotherium latidens
JF  - Current biology
N2  - Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1-4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [6-8]. However, mitochondrial phylogenies can be misled by hybridization [9], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [10], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [10]. To examine the evolutionary history of Homotherium, we generated a -7x nuclear genome and a similar to 38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (similar to 22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [5]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [3, 4, 11-14]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage.
Y1  - 2020
U6  - https://doi.org/10.1016/j.cub.2020.09.051
SN  - 0960-9822
SN  - 1879-0445
VL  - 30
IS  - 24
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Baroni, Gabriele
A1  - Francke, Till
T1  - An effective strategy for combining variance- and distribution-based global sensitivity analysis
JF  - Environmental modelling & software with environment data news
N2  - We present a new strategy for performing global sensitivity analysis capable to estimate main and interaction effects from a generic sampling design. The new strategy is based on a meaningful combination of varianceand distribution-based approaches. The strategy is tested on four analytic functions and on a hydrological model. Results show that the analysis is consistent with the state-of-the-art Saltelli/Jansen formula but to better quantify the interaction effect between the input factors when the output distribution is skewed. Moreover, the estimation of the sensitivity indices is much more robust requiring a smaller number of simulations runs. Specific settings and alternative methods that can be integrated in the new strategy are also discussed. Overall, the strategy is considered as a new simple and effective tool for performing global sensitivity analysis that can be easily integrated in any environmental modelling framework.
KW  - global sensitivity analysis
KW  - variance
KW  - distribution
KW  - generic sampling
KW  - design
Y1  - 2020
U6  - https://doi.org/10.1016/j.envsoft.2020.104851
SN  - 1364-8152
SN  - 1873-6726
VL  - 134
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Barthel, Martin
A1  - Bürkner, Hans-Joachim
T1  - Ukraine and the big moral divide
BT  - what biased media coverage means to East European borders
JF  - Geopolitics
N2  - Geopolitical shifts and the changing significance of borders in the EU's neighbourhood are usually understood as a matter of international power politics. Factors that accompany geopolitical impact on borders, such as media coverage of geopolitical change, often appear as secondary or irrelevant. However the recent Ukraine conflict revealed the contrary as pro-EU attitudes were strongly supported by 'western' media. Therefore this paper seeks to clarify the role of news media in creating perspectives and attitudes on geopolitical shifts and the significance of European borders. Empirical evidence on the coverage of the evolving Ukraine crisis by German news sources portrays the media as promoters of biased framings and imaginaries which suggest that the EU be a potential conflict party in the newly evolving geostrategic confrontation in its eastern neighbourhood. The findings indicate that during critical periods of the Ukraine crisis media reports combined rising euphoria about Europe and 'the West', as defenders of the 'good cause', with excessive moral polarising and the discursive normalisation of a rhetoric of escalation. Imaginaries of a bipolar world (The West against Russia) and a new Cold War prepared the ground for a new understanding of European borders and neighbourhood relations as being manipulable at will.
Y1  - 2019
U6  - https://doi.org/10.1080/14650045.2018.1561437
SN  - 1465-0045
SN  - 1557-3028
VL  - 25
IS  - 3
SP  - 633
EP  - 657
PB  - Routledge, Taylor & Francis Group
CY  - Philadelphia, Pa. [u.a]
ER  - 
TY  - JOUR
A1  - Bastian, Philipp U.
A1  - Nacak, Selma
A1  - Roddatis, Vladimir
A1  - Kumke, Michael Uwe
T1  - Tracking the motion of lanthanide ions within core-shell-shell NaYF4 nanocrystals via resonance energy transfer
JF  - The journal of physical chemistry : C
N2  - Lanthanide resonance energy transfer (LRET) was used to investigate the motion of dopant ions during the synthesis of core-shell-shell-nanocrystals (NCs) that are frequently used as frequency upconversion materials. Reaction conditions (temperature, solvent) as well as lattice composition and precursors were adapted from a typical hydrothermal synthesis approach used to obtain upconversion nanoparticles (UCNPs). Instead of adding the lanthanide ions Yb3+/Er3+ as the sensitizer/activator couple, Eu3+/Nd3+ as the donor/acceptor were added as the LRET pair to the outer shell (Eu-3) and the core (Nd-3). By tailoring the thickness of the insulation shell ("middle shell"), the expected distance between the donor and the acceptor was increased beyond 2 R-0, a distance for which no LRET is expected. The successful synthesis of core- shell-shell NCs with different thicknesses of the insulation layer was demonstrated by high-resolution transmission electron microscopy measurement. The incorporation of the Eu3+ ions into the NaYF4 lattice was investigated by high-resolution time-resolved luminescence measurements. Two major Eu3+ species (bulk and surface) were found. This was supported by steady-state as well as time-resolved luminescence data. Based on the luminescence decay kinetics, the intermixing of lanthanides during synthesis of core- shell UCNPs was evaluated. The energy transfer between Eu3+ (donor) and Nd3+ (acceptor) ions was exploited to quantify the motion of the dopant ions. This investigation reveals the migration of Ln(3+) ions between different compatiments in core-shell NCs and affects the concept of using core-shell architectures to increase the efficiency of UCNPs. In order to obtain well-separated core and shell structures with different dopants, alternative concepts are needed.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.jpcc.0c02588
SN  - 1932-7447
SN  - 1932-7455
VL  - 124
IS  - 20
SP  - 11229
EP  - 11238
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Bastian, Philipp U.
A1  - Yu, Leixiao
A1  - de Guereñu Kurganova, Anna Lopez
A1  - Haag, Rainer
A1  - Kumke, Michael Uwe
T1  - Bioinspired confinement of upconversion nanoparticles for improved performance in aqueous solution
JF  - The journal of physical chemistry : C, Nanomaterials and interfaces
N2  - The resonance energy transfer (RET) from NaYF4:Yb,Er upconverting nanoparticles (UNCPs) to a dye (5-carboxytetramethylrhodamine (TAMRA)) was investigated by photoluminescence experiments and microscale thermophoresis (MST). The dye was excited via RET from the UCNPs which was excited in the near-infrared (NIR). The change of the dye diffusion speed (free vs coupled) was investigated by MST. RET shows significant changes in the decay times of the dye as well as of the UCNPs. MST reveals significant changes in the diffusion speed. A unique amphiphilic coating polymer (customized mussel protein (CMP) polymer) for UCNP surface coating was used, which mimics blood protein adsorption and mussel food protein adhesion to transfer the UCNP into the aqueous phase and to allow surface functionalization. The CMP provides very good water dispersibility to the UCNPs and minimizes ligand exchange and subsequent UCNP aging reactions because of the interlinkage of the CMP on the UCNP surface. Moreover, CMP provides N-3-functional groups for dick chemistry-based functionalization demonstrated with the dye 5-carboxytetramethylrhodamine (TAMRA). This establishes the principle coupling scheme for suitable biomarkers such as antibodies. The CMP provides very stable aqueous UCNP dispersions that are storable up to 3 years in a fridge at 5 degrees C without dissolution or coagulation. The outstanding properties of CMP in shielding the UCNP from unwanted solvent effects is reflected in the distinct increase of the photoluminescence decay times after UCNP functionalization. The UCNP-to-TAMRA energy transfer is also spectroscopically investigated at low temperatures (4-200 K), revealing that one of the two green Er(III) emission bands contributes the major part to the energy transfer. The TAMRA fluorescence decay time increases by a factor of 9500 from 2.28 ns up to 22 mu s due to radiationless energy transfer from the UCNP after NIR excitation of the latter. This underlines the unique properties of CMP as a versatile capping ligand for distinctly improving the UCNPs' performance in aqueous solutions, for coupling of biomolecules, and for applications for in vitro and in vivo experiments using UCNPs as optical probes in life science applications.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.jpcc.0c09798
SN  - 1932-7447
SN  - 1932-7455
VL  - 124
IS  - 52
SP  - 28623
EP  - 28635
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Baxa, Ulrich
A1  - Weintraub, Andrej
A1  - Seckler, Robert
T1  - Self-competitive inhibition of the bacteriophage P22 Tailspike endorhamnosidase by O-antigen oligosaccharides
JF  - Biochemistry
N2  - The P22 tailspike endorhamnosidase confers the high specificity of bacteriophage P22 for some serogroups of Salmonella differing only slightly in their O-antigen polysaccharide. We used several biophysical methods to study the binding and hydrolysis of O-antigen fragments of different lengths by P22 tailspike protein. O-Antigen saccharides of defined length labeled with fluorophors could be purified with higher resolution than previously possible. Small amounts of naturally occurring variations of 0antigen fragments missing the nonreducing terminal galactose could be used to determine the contribution of this part to the free energy of binding to be similar to 7 kJ/mol. We were able to show via several independent lines of evidence that an unproductive binding mode is highly favored in binding over all other possible binding modes leading to hydrolysis. This is true even under circumstances under which the O-antigen fragment is long enough to be cleaved efficiently by the enzyme. The high-affinity unproductive binding mode results in a strong self-competitive inhibition in addition to product inhibition observed for this system. Self-competitive inhibition is observed for all substrates that have a free reducing end rhamnose. Naturally occurring O-antigen, while still attached to the bacterial outer membrane, does not have a free reducing end and therefore does not perform self-competitive inhibition.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.biochem.0c00872
SN  - 0006-2960
VL  - 59
IS  - 51
SP  - 4845
EP  - 4855
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Beckus, Siegfried
A1  - Bellissard, Jean
A1  - De Nittis, Giuseppe
T1  - Spectral continuity for aperiodic quantum systems
BT  - applications of a folklore theorem
JF  - Journal of mathematical physics
N2  - This work provides a necessary and sufficient condition for a symbolic dynamical system to admit a sequence of periodic approximations in the Hausdorff topology. The key result proved and applied here uses graphs that are called De Bruijn graphs, Rauzy graphs, or Anderson-Putnam complex, depending on the community. Combining this with a previous result, the present work justifies rigorously the accuracy and reliability of algorithmic methods used to compute numerically the spectra of a large class of self-adjoint operators. The so-called Hamiltonians describe the effective dynamic of a quantum particle in aperiodic media. No restrictions on the structure of these operators other than general regularity assumptions are imposed. In particular, nearest-neighbor correlation is not necessary. Examples for the Fibonacci and the Golay-Rudin-Shapiro sequences are explicitly provided illustrating this discussion. While the first sequence has been thoroughly studied by physicists and mathematicians alike, a shroud of mystery still surrounds the latter when it comes to spectral properties. In light of this, the present paper gives a new result here that might help uncovering a solution.
Y1  - 2020
U6  - https://doi.org/10.1063/5.0011488
SN  - 0022-2488
SN  - 1089-7658
VL  - 61
IS  - 12
PB  - American Institute of Physics
CY  - Melville, NY
ER  - 
TY  - JOUR
A1  - Beckus, Siegfried
A1  - Pinchover, Yehuda
T1  - Shnol-type theorem for the Agmon ground state
JF  - Journal of spectral theory
N2  - LetH be a Schrodinger operator defined on a noncompact Riemannianmanifold Omega, and let W is an element of L-infinity (Omega; R). Suppose that the operator H + W is critical in Omega, and let phi be the corresponding Agmon ground state. We prove that if u is a generalized eigenfunction ofH satisfying vertical bar u vertical bar <= C-phi in Omega for some constant C > 0, then the corresponding eigenvalue is in the spectrum of H. The conclusion also holds true if for some K is an element of Omega the operator H admits a positive solution in (Omega) over bar = Omega \ K, and vertical bar u vertical bar <= C psi in (Omega) over bar for some constant C > 0, where psi is a positive solution of minimal growth in a neighborhood of infinity in Omega. Under natural assumptions, this result holds also in the context of infinite graphs, and Dirichlet forms.
KW  - Shnol theorem
KW  - Caccioppoli inequality
KW  - Schrodinger operators
KW  - generalized eigenfunction
KW  - ground state
KW  - positive solutions
KW  - weighted
KW  - graphs
Y1  - 2020
U6  - https://doi.org/10.4171/JST/296
SN  - 1664-039X
SN  - 1664-0403
VL  - 10
IS  - 2
SP  - 355
EP  - 377
PB  - EMS Publishing House
CY  - Zürich
ER  - 
TY  - JOUR
A1  - Behl, Marc
A1  - Razzaq, Muhammad Yasar
A1  - Mazurek-Budzynska, Magdalena
A1  - Lendlein, Andreas
T1  - Polyetheresterurethane based porous scaffolds with tailorable architectures by supercritical CO2 foaming
JF  - MRS advances
N2  - Porous three-dimensional (3D) scaffolds are promising treatment options in regenerative medicine. Supercritical and dense-phase fluid technologies provide an attractive alternative to solvent-based scaffold fabrication methods. In this work, we report on the fabrication of poly-etheresterurethane (PPDO-PCL) based porous scaffolds with tailorable pore size, porosity, and pore interconnectivity by using supercritical CO2(scCO(2)) fluid-foaming. The influence of the processing parameters such as soaking time, soaking temperature and depressurization on porosity, pore size, and interconnectivity of the foams were investigated. The average pore diameter could be varied between 100-800 mu m along with a porosity in the range from (19 +/- 3 to 61 +/- 6)% and interconnectivity of up to 82%. To demonstrate their applicability as scaffold materials, selected foams were sterilized via ethylene oxide sterilization. They showed negligible cytotoxicity in tests according to DIN EN ISO 10993-5 and 10993-12 using L929 cells. The study demonstrated that the pore size, porosity and the interconnectivity of this multi-phase semicrystalline polymer could be tailored by careful control of the processing parameters during the scCO(2)foaming process. In this way, PPDO-PCL scaffolds with high porosity and interconnectivity are potential candidate materials for regenerative treatment options.
Y1  - 2020
U6  - https://doi.org/10.1557/adv.2020.345
SN  - 2059-8521
VL  - 5
IS  - 45
SP  - 2317
EP  - 2330
PB  - Cambridge University Press
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Behl, Marc
A1  - Zhao, Qian
A1  - Lendlein, Andreas
T1  - Glucose-responsive shape-memory cryogels
JF  - Journal of materials research : JMR
N2  - Boronic ester bonds can be reversibly formed between phenylboronic acid (PBA) and triol moieties. Here, we aim at a glucose-induced shape-memory effect by implementing such bonds as temporary netpoints, which are cleavable by glucose and by minimizing the volume change upon stimulation by a porous cryogel structure. The polymer system consisted of a semi-interpenetrating network (semi-IPN) architecture, in which the triol moieties were part of the permanent network and the PBA moieties were located in the linear polymer diffused into the semi-IPN. In an alkaline medium (pH = 10), the swelling ratio was approximately 35, independent of C-glu varied between 0 and 300 mg/dL. In bending experiments, shape fixity R-f approximate to 80% and shape recovery R-r approximate to 100% from five programming/recovery cycles could be determined. R-r was a function of C-glu in the range from 0 to 300 mg/dL, which accords with the fluctuation range of C-glu in human blood. In this way, the shape-memory hydrogels could play a role in future diabetes treatment options.
KW  - shape memory
KW  - polymer
KW  - porosity
Y1  - 2020
U6  - https://doi.org/10.1557/jmr.2020.204
SN  - 0884-2914
SN  - 2044-5326
VL  - 35
IS  - 18
SP  - 2396
EP  - 2404
PB  - Springer
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Behzadnia, Ali
A1  - Rad, Mehdi Mehrani
T1  - Young children’s activity involvement and responses to yes/no questions
JF  - Journal of psycholinguistic research
N2  - In the present study, we investigated younger and older Persian preschoolers' response tendency and accuracy toward yes/no questions about a coloring activity. Overall, 107 three- to four-year-olds and five- to six-year-old children were asked positive and negative yes/no questions about a picture coloring activity. The questions focused on three question contents namely, actions, environment and person. As for children's response tendency, they showed a compliance tendency. That is, they provided yes and no responses to positively and negatively formed questions respectively. Children especially younger ones were more compliant toward positive questions and their tendency decreased by age. In addition, the results revealed children's highest rate of compliance tendency toward environment inquiries. Concerning response accuracy, the effects of age and question content were significant. Specifically, older children provided more accurate responses than their younger counterparts, especially to yes/no questions asked about the actions performed during the activity. The findings suggest that depending on the format and the content of yes/no questions younger and older children's response accuracy and tendency differ.
KW  - compliance tendency
KW  - response accuracy
KW  - suggestibility
KW  - yes
KW  - no
KW  - questions
KW  - young children
Y1  - 2020
U6  - https://doi.org/10.1007/s10936-019-09685-4
SN  - 0090-6905
SN  - 1573-6555
VL  - 49
IS  - 3
SP  - 401
EP  - 414
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Beier, Grischa
A1  - Ullrich, André
A1  - Niehoff, Silke
A1  - Reißig, Malte
A1  - Habich, Matthias
T1  - Industry 4.0
BT  - how it is defined from a sociotechnical perspective and how much sustainability it includes - a literature review
JF  - Journal of cleaner production
N2  - Industry 4.0 has had a strong influence on the debate on the digitalization of industrial processes, despite being criticized for lacking a proper definition. However, Industry 4.0 might offer a huge chance to align the goals of a sustainable development with the ongoing digital transformation in industrial development. The main contribution of this paper is therefore twofold. We provide a de-facto definition of the concept "Industry 4.0" from a sociotechnical perspective based on its most often cited key features, as well as a thorough review of how far the concept of sustainability is incorporated in it.
KW  - sustainability
KW  - digitalization
KW  - manufacturing
KW  - Industry 4.0
KW  - definition
KW  - sociotechnical approach
Y1  - 2020
U6  - https://doi.org/10.1016/j.jclepro.2020.120856
SN  - 0959-6526
SN  - 1879-1786
VL  - 259
PB  - Elsevier Science
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Belasri, Khadija
A1  - Topal, Leila
A1  - Heydenreich, Matthias
A1  - Koch, Andreas
A1  - Kleinpeter, Erich
A1  - Fulop, Ferenc
A1  - Szatmari, Istvan
T1  - Synthesis and conformational analysis of naphthoxazine-fused phenanthrene derivatives
JF  - Molecules
N2  - The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel-Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with formaldehyde. Aminophenanthrol-type Mannich bases were synthesised and transformed to phenanthr[9,10-e][1,3]oxazines via [4 + 2] cycloaddition. Detailed NMR structural analyses of the new polyheterocycles as well as conformational studies including Density Functional Theory (DFT) modelling were performed. The relative stability of ortho-quinone methides (o-QMs) was calculated, the geometries obtained were compared with the experimentally determined NMR structures, and thereby, the regioselectivity of the reactions has been assigned.
KW  - modified Mannich reaction
KW  - cyclic imines
KW  - [4+2] cycloaddition
KW  - NMR
KW  - spectroscopy
KW  - conformational analysis
KW  - DFT calculations
Y1  - 2020
U6  - https://doi.org/10.3390/molecules25112524
SN  - 1420-3049
VL  - 25
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Ben Dor, Yoav
A1  - Neugebauer, Ina
A1  - Enzel, Yehouda
A1  - Schwab, Markus J.
A1  - Tjallingii, Rik
A1  - Erel, Yigal
A1  - Brauer, Achim
T1  - Reply to comment on: Ben Dor, Yoav et al. : Varves of the Dead Sea sedimentary record. - In: Quaternary science reviews : the international multidisciplinary research and review journal. - 215 (2019), S. 173 - 184. - (ISSN: 0277-3791). - https://doi.org/10.1016/j.quascirev.2019.04.011
JF  - Quaternary science reviews : the international multidisciplinary research and review journal
N2  - In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion.
Y1  - 2020
U6  - https://doi.org/10.1016/j.quascirev.2019.106063
SN  - 0277-3791
VL  - 231
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Bender, Benedict
T1  - The impact of integration on application success and customer satisfaction in mobile device platforms
JF  - Business & information systems engineering : the international journal of Wirtschaftsinformatik
N2  - Digital software platforms allow third parties to develop applications and thus extend their functionality. Platform owners provide platform boundary resources that allow for application development. For developers, platform integration, understood as the employment of platform resources, helps to realize application functionality effectively. Simultaneously, it requires integration effort and increases dependencies. Developers are interested to know whether integration contributes to success in hypercompetitive platform settings. While aspects of platform participation have been studied, research on a comprehensive notion of integration and related implications are missing. By proposing a platform integration model, this study supports a better understanding of integration. Concerning dynamics related to integration, effects were tested using information from over 82,000 Apple AppStore applications. Regression model analysis reveals that application success and customer satisfaction is positively influenced by platform integration. To achieve superior results, developers should address multiple aspects of integration, such as devices, data, the operating system, the marketplace as well as other applications, and provide updates. Finally, the study highlights the importance for all platform participants and their possibilities to employ integration as a strategic instrument.
KW  - Integration
KW  - Digital platforms
KW  - Boundary resources
KW  - Application success
KW  - Customer satisfaction
KW  - Mobile device platforms
Y1  - 2020
U6  - https://doi.org/10.1007/s12599-020-00629-0
SN  - 2363-7005
SN  - 1867-0202
VL  - 62
IS  - 6
SP  - 515
EP  - 533
PB  - Springer Fachmedien Wiesbaden GmbH
CY  - Wiesbaden
ER  - 
TY  - JOUR
A1  - Bentz, Stephan
A1  - Kwiatek, Grzegorz
A1  - Martinez-Garzon, Patricia
A1  - Bohnhoff, Marco
A1  - Dresen, Georg
T1  - Seismic moment evolution during hydraulic stimulations
JF  - Geophysical research letters
N2  - Analysis of past and present stimulation projects reveals that the temporal evolution and growth of maximum observed moment magnitudes may be linked directly to the injected fluid volume and hydraulic energy. Overall evolution of seismic moment seems independent of the tectonic stress regime and is most likely governed by reservoir specific parameters, such as the preexisting structural inventory. Data suggest that magnitudes can grow either in a stable way, indicating the constant propagation of self-arrested ruptures, or unbound, for which the maximum magnitude is only limited by the size of tectonic faults and fault connectivity. Transition between the two states may occur at any time during injection or not at all. Monitoring and traffic light systems used during stimulations need to account for the possibility of unstable rupture propagation from the very beginning of injection by observing the entire seismicity evolution in near-real time and at high resolution for an immediate reaction in injection strategy. 

Plain Language Summary Predicting and controlling the size of earthquakes caused by fluid injection is currently the major concern of many projects associated with geothermal energy production. Here, we analyze the magnitude and seismic moment evolution with injection parameters for prominent geothermal and scientific projects to date. Evolution of seismicity seems to be largely independent of the tectonic stress background and seemingly depends on reservoir specific characteristics. We find that the maximum observed magnitudes relate linearly to the injected volume or hydraulic energy. A linear relation suggests stable growth of induced ruptures, as predicted by current models, or rupture growth may no longer depend on the stimulated volume but on tectonics. A system may change between the two states during the course of fluid injection. Close-by and high-resolution monitoring of seismic and hydraulic parameters in near-real time may help identify these fundamental changes in ample time to change injection strategy and manage maximum magnitudes.
Y1  - 2020
U6  - https://doi.org/10.1029/2019GL086185
SN  - 0094-8276
SN  - 1944-8007
VL  - 47
IS  - 5
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Bertels, Jana
A1  - Schulze-Gabrechten, Lena
T1  - Mapping the black box of intraministerial organization
BT  - An analytical approach to explore structural diversity below the portfolio level
JF  - Governance : an international journal of policy and administration and institutions
N2  - This article explores the structural diversity of intraministerial organization over time. Based on organization theory, it proposes a generic typology for intraministerial units applicable to any hierarchically structured government organization. We empirically investigate the critical case of the German federal bureaucracy. By classifying its subunits, we analyze the longitudinal development of structural differentiation and its correspondence to denominational variety. The data stem from a novel international dataset, covering all ministries between 1980 and 2015. We find that intraministerial structure differentiates over time, across and within ministries. A stable core of traditional Weberian structure is complemented by structurally innovative intraministerial units. We conclude that the German federal bureaucracy is more diverse than suggested in previous literature. Our findings indicate that less Weberian bureaucracies are at least as structurally diverse and that more reform-driven bureaucracies will have experienced at least as many changes in structural diversity.
KW  - continuity
KW  - government
KW  - impact
KW  - public management
KW  - reforms
KW  - state
Y1  - 2020
U6  - https://doi.org/10.1111/gove.12486
SN  - 0952-1895
SN  - 1468-0491
VL  - 34
IS  - 1
SP  - 171
EP  - 189
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Beta, Carsten
A1  - Gov, Nir S.
A1  - Yochelis, Arik
T1  - Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
JF  - Cells
N2  - During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-temporal scales. However, the corresponding coarse-grained theory mostly avoids the full complexity of this multi-scale phenomenon. In this perspective, we focus on a minimal continuum model of activator–inhibitor type and highlight the qualitative role of mass conservation, which is typically overlooked. Specifically, our interest is to connect between the mathematical mechanisms of pattern formation in the presence of a large-scale mode, due to mass conservation, and distinct behaviors of actin waves.
KW  - nonlinear waves
KW  - actin polymerization
KW  - bifurcation theory
KW  - mass conservation
KW  - spatial localization
KW  - pattern formation
KW  - activator–inhibitor models
Y1  - 2020
U6  - https://doi.org/10.3390/cells9061533
SN  - 2073-4409
VL  - 9
IS  - 6
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Bevacqua, Luca
A1  - Scheffler, Tatjana
T1  - Form variation of pronominal it-clefts in written English
BT  - a corpus study in Twitter and iWeb
JF  - Linguistics vanguard
N2  - Clefts are well-studied as a construction which induces emphasis on its clefted referent. However, little is known about the distribution of different stylistic forms of it-cleft variants. We report on a corpus study mining data from Twitter, targeting sentences clefting a pronoun in English. We examine the following features: case and syntactic role of the clefted pronoun, contraction of the copula, choice of complementiser and use of emphasis markers. The results show systematic associations between these features. A further comparison between the Twitter dataset and data from iWeb, a corpus of general-use web language, shows significant differences in levels of emphasis and formality, positioning Twitter language in the middle of the conceptual orality spectrum.
KW  - clefts
KW  - corpus study
KW  - English
KW  - emphasis
KW  - computer-mediated communication
Y1  - 2020
U6  - https://doi.org/10.1515/lingvan-2019-0066
SN  - 2199-174X
VL  - 6
IS  - 1
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bilbao-Lasa, Peru
A1  - Jara Muñoz, Julius
A1  - Pedoja, Kevin
A1  - Álvarez, Irantzu
A1  - Aranburu, Arantza
A1  - Iriarte, Eneko
A1  - Galparsoro, Ibon
T1  - Submerged marine terraces identification and an approach for numerical modeling the sequence formation in the Bay of Biscay (Northeastern Iberian Peninsula)
JF  - Frontiers in Earth Science
N2  - Submerged sequences of marine terraces potentially provide crucial information of past sea-level positions. However, the distribution and characteristics of drowned marine terrace sequences are poorly known at a global scale. Using bathymetric data and novel mapping and modeling techniques, we studied a submerged sequence of marine terraces in the Bay of Biscay with the objective to identify the distribution and morphologies of submerged marine terraces and the timing and conditions that allowed their formation and preservation. To accomplish the objectives a high-resolution bathymetry (5 m) was analyzed using Geographic Information Systems and TerraceM(R). The successive submerged terraces were identified using a Surface Classification Model, which linearly combines the slope and the roughness of the surface to extract fossil sea-cliffs and fossil rocky shore platforms. For that purpose, contour and hillshaded maps were also analyzed. Then, shoreline angles, a geomorphic marker located at the intersection between the fossil sea-cliff and platform, were mapped analyzing swath profiles perpendicular to the isobaths. Most of the submerged strandlines are irregularly preserved throughout the continental shelf. In summary, 12 submerged terraces with their shoreline angles between approximately: -13 m (T1), -30 and -32 m (T2), -34 and 41 m (T3), -44 and -47 m (T4), -49 and 53 m (T5), -55 and 58 m (T6), -59 and 62 m (T7), -65 and 67 m (T8), -68 and 70 m (T9), -74 and -77 m (T10), -83 and -86 m (T11) and -89 and 92 m (T12). Nevertheless, the ones showing the best lateral continuity and preservation in the central part of the shelf are T3, T4, T5, T7, T8, and T10. The age of the terraces has been estimated using a landscape evolution model. To simulate the formation and preservation of submerged terraces three different scenarios: (i) 20-0 ka; (ii) 128-0 ka; and (iii) 128-20 ka, were compared. The best scenario for terrace generation was between 128 and 20 Ka, where T3, T5, and T7 could have been formed.
KW  - marine terrace
KW  - submerged sequence
KW  - digital bathymetric model
KW  - TerraceM
KW  - numerical modeling
KW  - Bay of Biscay
Y1  - 2020
U6  - https://doi.org/10.3389/feart.2020.00047
SN  - 2296-6463
VL  - 8
IS  - 47
SP  - 1
EP  - 20
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bin Tareaf, Raad
A1  - Berger, Philipp
A1  - Hennig, Patrick
A1  - Meinel, Christoph
T1  - Cross-platform personality exploration system for online social networks
BT  - Facebook vs. Twitter
JF  - Web intelligence
N2  - Social networking sites (SNS) are a rich source of latent information about individual characteristics. Crawling and analyzing this content provides a new approach for enterprises to personalize services and put forward product recommendations. In the past few years, commercial brands made a gradual appearance on social media platforms for advertisement, customers support and public relation purposes and by now it became a necessity throughout all branches. This online identity can be represented as a brand personality that reflects how a brand is perceived by its customers. We exploited recent research in text analysis and personality detection to build an automatic brand personality prediction model on top of the (Five-Factor Model) and (Linguistic Inquiry and Word Count) features extracted from publicly available benchmarks. Predictive evaluation on brands' accounts reveals that Facebook platform provides a slight advantage over Twitter platform in offering more self-disclosure for users' to express their emotions especially their demographic and psychological traits. Results also confirm the wider perspective that the same social media account carry a quite similar and comparable personality scores over different social media platforms. For evaluating our prediction results on actual brands' accounts, we crawled the Facebook API and Twitter API respectively for 100k posts from the most valuable brands' pages in the USA and we visualize exemplars of comparison results and present suggestions for future directions.
KW  - Big Five model
KW  - personality prediction
KW  - brand personality
KW  - machine
KW  - learning
KW  - social media analysis
Y1  - 2020
U6  - https://doi.org/10.3233/WEB-200427
SN  - 2405-6456
SN  - 2405-6464
VL  - 18
IS  - 1
SP  - 35
EP  - 51
PB  - IOS Press
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bindenagel Šehović, Annamarie
T1  - Towards a new definition of health security
BT  - a three-part rationale for the twenty-first century
JF  - Global public health : an international journal for research, policy and practice
N2  - In recent years the framings of global health security have shifted while the structures governing global health have largely remained the same. One feature of the emerging re-ordering is the unresolved allocation of accountability between state and non-state actors. This brings to critical challenges to global health security to the fore. The first is that the consensus on the seeming shift from state to human security framing with regard to the global human right to health (security) risks losing its salience. Second, this conceptual challenge is mirrored on the operational level: if states and non-state actors do not assume responsibility for health security, who or what can guarantee health security? In order to address global health security against the backdrop of these twenty-first Century challenges, this article proceeds in three parts. First, it analyses the shortcomings of the current state-based World Health Organization (WHO) definition of health security. Second, taking into account the rising pressures posed to global health security and the inadequacy both of state-based and of ad hoc non-state responses, it proposes a new framing. Third, the article offers initial insights into the operational application of beyond state responses to (health) security challenges.
KW  - health security
KW  - citizenship
KW  - borders
KW  - state security
KW  - responsibility
Y1  - 2020
U6  - https://doi.org/10.1080/17441692.2019.1634119
SN  - 1744-1692
SN  - 1744-1706
VL  - 15
IS  - 1
SP  - 1
EP  - 12
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon, Oxfordshire
ER  - 
TY  - JOUR
A1  - Birnick, Johann
A1  - Bläsius, Thomas
A1  - Friedrich, Tobias
A1  - Naumann, Felix
A1  - Papenbrock, Thorsten
A1  - Schirneck, Friedrich Martin
T1  - Hitting set enumeration with partial information for unique column combination discovery
JF  - Proceedings of the VLDB Endowment
N2  - Unique column combinations (UCCs) are a fundamental concept in relational databases. They identify entities in the data and support various data management activities. Still, UCCs are usually not explicitly defined and need to be discovered. State-of-the-art data profiling algorithms are able to efficiently discover UCCs in moderately sized datasets, but they tend to fail on large and, in particular, on wide datasets due to run time and memory limitations. <br /> In this paper, we introduce HPIValid, a novel UCC discovery algorithm that implements a faster and more resource-saving search strategy. HPIValid models the metadata discovery as a hitting set enumeration problem in hypergraphs. In this way, it combines efficient discovery techniques from data profiling research with the most recent theoretical insights into enumeration algorithms. Our evaluation shows that HPIValid is not only orders of magnitude faster than related work, it also has a much smaller memory footprint.
Y1  - 2020
U6  - https://doi.org/10.14778/3407790.3407824
SN  - 2150-8097
VL  - 13
IS  - 11
SP  - 2270
EP  - 2283
PB  - Association for Computing Machinery
CY  - [New York, NY]
ER  - 
TY  - JOUR
A1  - Bishop, Christopher Allen
A1  - Schulze, Matthias Bernd
A1  - Klaus, Susanne
A1  - Weitkunat, Karolin
T1  - The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism
JF  - The FASEB journal : the official journal of the Federation of American Societies for Experimental Biology
N2  - Dairy intake, as a source of branched-chain amino acids (BCAA), has been linked to a lower incidence of type-2-diabetes and increased circulating odd-chain fatty acids (OCFA). To understand this connection, we aimed to investigate differences in BCAA metabolism of leucine and valine, a possible source of OCFA, and their role in hepatic metabolism. Male mice were fed a high-fat diet supplemented with leucine and valine for 1 week and phenotypically characterized with a focus on lipid metabolism. Mouse primary hepatocytes were treated with the BCAA or a Ppar alpha activator WY-14643 to systematically examine direct hepatic effects and their mechanisms. Here, we show that only valine supplementation was able to increase hepatic and circulating OCFA levels via two pathways; a PPAR alpha-dependent induction of alpha-oxidation and an increased supply of propionyl-CoA for de novo lipogenesis. Meanwhile, we were able to confirm leucine-mediated effects on the inhibition of food intake and transport of fatty acids, as well as induction of S6 ribosomal protein phosphorylation. Taken together, these data illustrate differential roles of the BCAA in lipid metabolism and provide preliminary evidence that exclusively valine contributes to the endogenous formation of OCFA which is important for a better understanding of these metabolites in metabolic health.
KW  - fatty acid metabolism
KW  - leucine
KW  - liver
KW  - OCFA
KW  - valine
Y1  - 2020
U6  - https://doi.org/10.1096/fj.202000195R
SN  - 0892-6638
SN  - 1530-6860
VL  - 34
IS  - 7
SP  - 9727
EP  - 9739
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Bittmann, Frank
A1  - Dech, Silas
A1  - Aehle, Markus
A1  - Schaefer, Laura
T1  - Manual Muscle Testing—Force Profiles and Their Reproducibility
JF  - Diagnostics
N2  - The manual muscle test (MMT) is a flexible diagnostic tool, which is used in many disciplines, applied in several ways. The main problem is the subjectivity of the test. The MMT in the version of a “break test” depends on the tester’s force rise and the patient’s ability to resist the applied force. As a first step, the investigation of the reproducibility of the testers’ force profile is required for valid application. The study examined the force profiles of n = 29 testers (n = 9 experiences (Exp), n = 8 little experienced (LitExp), n = 12 beginners (Beg)). The testers performed 10 MMTs according to the test of hip flexors, but against a fixed leg to exclude the patient’s reaction. A handheld device recorded the temporal course of the applied force. The results show significant differences between Exp and Beg concerning the starting force (padj = 0.029), the ratio of starting to maximum force (padj = 0.005) and the normalized mean Euclidean distances between the 10 trials (padj = 0.015). The slope is significantly higher in Exp vs. LitExp (p = 0.006) and Beg (p = 0.005). The results also indicate that experienced testers show inter-tester differences and partly even a low intra-tester reproducibility. This highlights the necessity of an objective MMT-assessment. Furthermore, an agreement on a standardized force profile is required. A suggestion for this is given.
KW  - manual muscle testing
KW  - neuromuscular diagnostics
KW  - force profiles
KW  - reproducibility
KW  - adaptive force
KW  - handheld device
Y1  - 2020
U6  - https://doi.org/10.3390/diagnostics10120996
SN  - 2075-4418
VL  - 10
IS  - 12
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Blanchard, Gilles
A1  - Mücke, Nicole
T1  - Kernel regression, minimax rates and effective dimensionality
BT  - beyond the regular case
JF  - Analysis and applications
N2  - We investigate if kernel regularization methods can achieve minimax convergence rates over a source condition regularity assumption for the target function. These questions have been considered in past literature, but only under specific assumptions about the decay, typically polynomial, of the spectrum of the the kernel mapping covariance operator. In the perspective of distribution-free results, we investigate this issue under much weaker assumption on the eigenvalue decay, allowing for more complex behavior that can reflect different structure of the data at different scales.
KW  - Kernel regression
KW  - minimax optimality
KW  - eigenvalue decay
Y1  - 2020
U6  - https://doi.org/10.1142/S0219530519500258
SN  - 0219-5305
SN  - 1793-6861
VL  - 18
IS  - 4
SP  - 683
EP  - 696
PB  - World Scientific
CY  - New Jersey
ER  - 
TY  - JOUR
A1  - Bludau, Mark-Jan
A1  - Brüggemann, Viktoria
A1  - Busch, Anke
A1  - Dörk, Marian
T1  - Reading traces
BT  - scalable exploration in elastic visualizations of cultural heritage data
JF  - Computer graphics forum : journal of the European Association for Computer Graphics
N2  - Through a design study, we develop an approach to data exploration that utilizes elastic visualizations designed to support varying degrees of detail and abstraction. Examining the notions of scalability and elasticity in interactive visualizations, we introduce a visualization of personal reading traces such as marginalia or markings inside the reference library of German realist author Theodor Fontane. To explore such a rich and extensive collection, meaningful visual forms of abstraction and detail are as important as the transitions between those states. Following a growing research interest in the role of fluid interactivity and animations between views, we are particularly interested in the potential of carefully designed transitions and consistent representations across scales. The resulting prototype addresses humanistic research questions about the interplay of distant and close reading with visualization research on continuous navigation along several granularity levels, using scrolling as one of the main interaction mechanisms. In addition to presenting the design process and resulting prototype, we present findings from a qualitative evaluation of the tool, which suggest that bridging between distant and close views can enhance exploration, but that transitions between views need to be crafted very carefully to facilitate comprehension.
Y1  - 2020
U6  - https://doi.org/10.1111/cgf.13964
SN  - 0167-7055
SN  - 1467-8659
VL  - 39
IS  - 3
SP  - 77
EP  - 87
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Bobzien, Licia
A1  - Kalleitner, Fabian
T1  - Attitudes towards European financial solidarity during the Covid-19 pandemic
BT  - evidence from a net-contributor country
JF  - European societies
N2  - Whilst the Covid-19 pandemic affects all European countries, the ways in which these countries are prepared for the health and subsequent economic crisis varies considerably. Financial solidarity within the European Union (EU) could mitigate some of these inequalities but depends upon the support of the citizens of individual member states for such policies. This paper studies attitudes of the Austrian population - a net-contributor to the European budget - towards financial solidarity using two waves of the Austrian Corona Panel Project collected in May and June 2020. We find that individuals (i) who are less likely to consider the Covid-19 pandemic as a national economic threat, (ii) who believe that Austria benefits from supporting other countries, and (iii) who prefer the crisis to be organized more centrally at EU-level show higher support for European financial solidarity. Using fixed effects models, we further show that perceiving economic threats and preferring central crisis management also explain attitude dynamics within individuals over time. We conclude that cost-benefit perceptions are important determinants for individual support of European financial solidarity during the Covid-19 pandemic.
KW  - Covid-19
KW  - financial solidarity
KW  - European Union
KW  - Austria
Y1  - 2020
U6  - https://doi.org/10.1080/14616696.2020.1836669
SN  - 1461-6696
SN  - 1469-8307
VL  - 23
IS  - Sup. 1
SP  - S791
EP  - S804
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Boekstegers, Felix
A1  - Marcelain, Katherine
A1  - Barahona Ponce, Carol
A1  - Baez Benavides, Pablo F.
A1  - Müller, Bettina
A1  - de Toro, Gonzalo
A1  - Retamales, Javier
A1  - Barajas, Olga
A1  - Ahumada, Monica
A1  - Aleksandrova, Krasimira
A1  - Bermejo, Justo Lorenzo
T1  - ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
JF  - Cancer Epidemiology
N2  - Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.
Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.
Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.
Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
KW  - cancer epidemiology
KW  - gallbladder cancer
KW  - native American ancestry
KW  - population-specific risk marker
Y1  - 2020
VL  - 65
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Boergens, Eva
A1  - Güntner, Andreas
A1  - Dobslaw, Henryk
A1  - Dahle, Christoph
T1  - Quantifying the Central European droughts in 2018 and 2019 with GRACE Follow-On
JF  - Geophysical research letters : GRL
N2  - The GRACE-FO satellites launched in May 2018 are able to quantify the water mass deficit in Central Europe during the two consecutive summer droughts of 2018 and 2019. Relative to the long-term climatology, the water mass deficits were-112 +/- 10.5 Gt in 2018 and-145 +/- 12 Gt in 2019. These deficits are 73% and 94% of the mean amplitude of seasonal water storage variations, which is so severe that a recovery cannot be expected within 1 year. The water deficits in 2018 and 2019 are the largest in the whole GRACE and GRACE-FO time span. Globally, the data do not show an offset between the two missions, which proves the successful continuation of GRACE by GRACE-FO and thus the reliability of the observed extreme events in Central Europe. This allows for a joint assessment of the four Central European droughts in 2003, 2015, 2018, and 2019 in terms of total water storage deficits.
KW  - GRACE-FO
KW  - GRACE
KW  - drought
KW  - Central European drought 2018
KW  - Central European drought 2019
Y1  - 2020
U6  - https://doi.org/10.1029/2020GL087285
SN  - 0094-8276
SN  - 1944-8007
VL  - 47
IS  - 14
PB  - American Geophysical Union
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Bohn, Nicolai
A1  - Kundisch, Dennis
T1  - What are we talking about when we talk about technology pivots?
BT  - a Delphi study
JF  - Information & management
N2  - Technology pivots were designed to help digital startups make adjustments to the technology underpinning their products and services. While academia and the media make liberal use of the term "technology pivot," they rarely align themselves to Ries' foundational conceptualization. Recent research suggests that a more granulated conceptualization of technology pivots is required. To scientifically derive a comprehensive conceptualization, we conduct a Delphi study with a panel of 38 experts drawn from academia and practice to explore their understanding of "technology pivots." Our study thus makes an important contribution to advance the seminal work by Ries on technology pivots.
KW  - digital startup
KW  - lean startup approach
KW  - technology pivot
KW  - conceptualization
KW  - Delphi study
Y1  - 2020
U6  - https://doi.org/10.1016/j.im.2020.103319
SN  - 0378-7206
SN  - 1872-7530
VL  - 57
IS  - 6
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Boldrighini, Carlo
A1  - Frigio, Sandro
A1  - Maponi, Pierluigi
A1  - Pellegrinotti, Alessandro
A1  - Sinai, Yakov G.
T1  - 3-D incompressible Navier-Stokes equations: Complex blow-up and related real flows
JF  - Lectures in pure and applied mathematics
KW  - random point processes
KW  - statistical mechanics
KW  - stochastic analysis
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-472201
SN  - 978-3-86956-485-2
SN  - 2199-4951
SN  - 2199-496X
IS  - 6
SP  - 185
EP  - 194
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Bolius, Sarah
A1  - Karoline Morling, 
A1  - Wiedner, Claudia
A1  - Weithoff, Guntram
T1  - Genetic Identity and Herbivory Drive the Invasion of a Common Aquatic Microbial Invader
JF  - Frontiers in Microbiology
N2  - Despite the increasing number of species invasions, the factors driving invasiveness are still under debate. This is particularly the case for “invisible” invasions by aquatic microbial species. Since in many cases only a few individuals or propagules enter a new habitat, their genetic variation is low and might limit their invasion success, known as the genetic bottleneck. Thus, a key question is, how genetic identity and diversity of invading species influences their invasion success and, subsequently, affect the resident community. We conducted invader-addition experiments using genetically different strains of the globally invasive, aquatic cyanobacterium Raphidiopsis raciborskii (formerly: Cylindrospermopsis raciborskii) to determine the role of invader identity and genetic diversity (strain richness) at four levels of herbivory. We tested the invasion success of solitary single strain invasions against the invader genetic diversity, which was experimentally increased up to ten strains (multi-strain populations). By using amplicon sequencing we determined the strain-specific invasion success in the multi-strain treatments and compared those with the success of these strains in the single-strain treatments. Furthermore, we tested for the invasion success under different herbivore pressures. We showed that high grazing pressure by a generalist herbivore prevented invasion, whereas a specialist herbivore enabled coexistence of consumer and invader. We found a weak effect of diversity on invasion success only under highly competitive conditions. When invasions were successful, the magnitude of this success was strain-specific and consistent among invasions performed with single-strain or multi-strain populations. A strain-specific effect was also observed on the resident phytoplankton community composition, highlighting the strong role of invader genetic identity. Our results point to a strong effect of the genetic identity on the invasion success under low predation pressure. The genetic diversity of the invader population, however, had little effect on invasion success in our study, in contrast to most previous findings. Instead, it is the interaction between the consumer abundance and type together with the strain identity of the invader that defined invasion success. This study underlines the importance of strain choice in invasion research and in ecological studies in general.
KW  - alien species
KW  - genotype
KW  - invasibility
KW  - cyanobacteria
KW  - consumptive resistance
KW  - phytoplankton
KW  - Raphidiopsis
KW  - genetic diversity
Y1  - 2019
U6  - https://doi.org/10.3389/fmicb.2020.01598
SN  - 1664-302X
VL  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Boll-Avetisyan, Natalie
A1  - Bhatara, Anjali
A1  - Höhle, Barbara
T1  - Processing of rhythm in speech and music in adult dyslexia
JF  - Brain Sciences
N2  - Recent studies have suggested that musical rhythm perception ability can affect the phonological system. The most prevalent causal account for developmental dyslexia is the phonological deficit hypothesis. As rhythm is a subpart of phonology, we hypothesized that reading deficits in dyslexia are associated with rhythm processing in speech and in music. In a rhythmic grouping task, adults with diagnosed dyslexia and age-matched controls listened to speech streams with syllables alternating in intensity, duration, or neither, and indicated whether they perceived a strong-weak or weak-strong rhythm pattern. Additionally, their reading and musical rhythm abilities were measured. Results showed that adults with dyslexia had lower musical rhythm abilities than adults without dyslexia. Moreover, lower musical rhythm ability was associated with lower reading ability in dyslexia. However, speech grouping by adults with dyslexia was not impaired when musical rhythm perception ability was controlled: like adults without dyslexia, they showed consistent preferences. However, rhythmic grouping was predicted by musical rhythm perception ability, irrespective of dyslexia. The results suggest associations among musical rhythm perception ability, speech rhythm perception, and reading ability. This highlights the importance of considering individual variability to better understand dyslexia and raises the possibility that musical rhythm perception ability is a key to phonological and reading acquisition.
KW  - developmental dyslexia
KW  - Iambic/Trochaic Law
KW  - rhythmic grouping
KW  - musicality
KW  - speech perception
KW  - rhythm perception
Y1  - 2020
U6  - https://doi.org/10.3390/brainsci10050261
SN  - 2076-3425
VL  - 10
IS  - 5
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Boll-Avetisyan, Natalie
A1  - Bhatara, Anjali
A1  - Unger, Annika
A1  - Nazzi, Thierry
A1  - Höhle, Barbara
T1  - Rhythmic grouping biases in simultaneous bilinguals
JF  - Bilingualism : language and cognition
N2  - This study provides a novel approach for testing the universality of perceptual biases by looking at speech processing in simultaneous bilingual adults learning two languages that support the maintenance of this bias to different degrees. Specifically, we investigated the Iambic/Trochaic Law, an assumed universal grouping bias, in simultaneous French-German bilinguals, presenting them with streams of syllables varying in intensity, duration or neither and asking them whether they perceived them as strong-weak or weak-strong groupings. Results showed robust, consistent grouping preferences. A comparison to monolinguals from previous studies revealed that they pattern with German-speaking monolinguals, and differ from French-speaking monolinguals. The distribution of simultaneous bilinguals' individual performance was best explained by a model fitting a unimodal (not bimodal) distribution, failing to support two subgroups of language dominance. Moreover, neither language experience nor language context predicted their performance. These findings suggest a special role for universal biases in simultaneous bilinguals.
KW  - simultaneous bilingualism
KW  - universal bias
KW  - rhythm
KW  - rhythmic grouping
KW  - Iambic
KW  - Trochaic Law
Y1  - 2020
U6  - https://doi.org/10.1017/S1366728920000140
SN  - 1366-7289
SN  - 1469-1841
VL  - 23
IS  - 5
SP  - 1070
EP  - 1081
PB  - Cambridge Univ. Press
CY  - New York
ER  - 
TY  - JOUR
A1  - Bondü, Rebecca
A1  - Bilgin, Ayten
A1  - Warschburger, Petra
T1  - Justice sensitivity and rejection sensitivity as predictors and outcomes of eating disorder pathology
BT  - a 5-year longitudinal study
JF  - The international journal of eating disorders
N2  - Objective:
Rejection sensitivity and justice sensitivity are personality traits that are characterized by frequent perceptions and intense adverse responses to negative social cues. Whereas there is good evidence for associations between rejection sensitivity, justice sensitivity, and internalizing problems, no longitudinal studies have investigated their association with eating disorder (ED) pathology so far. Thus, the present study examined longitudinal relations between rejection sensitivity, justice sensitivity, and ED pathology. 

Method:
Participants (N = 769) reported on their rejection sensitivity, justice sensitivity, and ED pathology at 9-19 (T1), 11-21 (T2), and 14-22 years of age (T3). 

Results:
Latent cross-lagged models showed longitudinal associations between ED pathology and anxious rejection sensitivity, observer and victim justice sensitivity. T1 and T2 ED pathology predicted higher T2 and T3 anxious rejection sensitivity, respectively. In turn, T2 anxious rejection sensitivity predicted more T3 ED pathology. T1 observer justice sensitivity predicted more T2 ED pathology, which predicted higher T3 observer justice sensitivity. Furthermore, T1 ED pathology predicted higher T2 victim justice sensitivity. 

Discussion:
Rejection sensitivity-particularly anxious rejection sensitivity-and justice sensitivity may be involved in the maintenance or worsening of ED pathology and should be considered by future research and in prevention and treatment of ED pathology. Also, mental health problems may increase rejection sensitivity and justice sensitivity traits in the long term.
KW  - eating disorder pathology
KW  - justice sensitivity
KW  - longitudinal
KW  - rejection
KW  - sensitivity
Y1  - 2020
U6  - https://doi.org/10.1002/eat.23273
SN  - 0276-3478
SN  - 1098-108X
VL  - 53
IS  - 6
SP  - 926
EP  - 936
PB  - Wiley
CY  - New York, NY
ER  - 
TY  - JOUR
A1  - Borck, Rainald
A1  - Schrauth, Philipp
T1  - Population density and urban air quality
JF  - Regional science and urban economics
N2  - We use panel data from Germany to analyze the effect of population density on urban air pollution (nitrogen oxides, particulate matter, ozone, and an aggregate index for bad air quality [AQI]). To address unobserved heterogeneity and omitted variables, we present long difference/fixed effects estimates and instrumental variables estimates, using historical population and soil quality as instruments. Using our preferred estimates, we find that the concentration increases with density for NO2 with an elasticity of 0.25 and particulate matter with elasticity of 0.08. The O-3 concentration decreases with density with an elasticity of -0.14. The AQI increases with density, with an elasticity of 0.11-0.13. We also present a variety of robustness tests. Overall, the paper shows that higher population density worsens local air quality.
KW  - Population density
KW  - Air pollution
Y1  - 2020
U6  - https://doi.org/10.1016/j.regsciurbeco.2020.103596
SN  - 0166-0462
SN  - 1879-2308
VL  - 86
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bordihn, Henning
A1  - Mitrana, Victor
T1  - On the degrees of non-regularity and non-context-freeness
JF  - Journal of computer and system sciences
N2  - We study the derivational complexity of context-free and context-sensitive grammars by counting the maximal number of non-regular and non-context-free rules used in a derivation, respectively. The degree of non-regularity/non-context-freeness of a language is the minimum degree of non-regularity/non-context-freeness of context-free/context-sensitive grammars generating it. A language has finite degree of non-regularity iff it is regular. We give a condition for deciding whether the degree of non-regularity of a given unambiguous context-free grammar is finite. The problem becomes undecidable for arbitrary linear context-free grammars. The degree of non-regularity of unambiguous context-free grammars generating non-regular languages as well as that of grammars generating deterministic context-free languages that are not regular is of order Omega(n). Context-free non-regular languages of sublinear degree of non-regularity are presented. A language has finite degree of non-context-freeness if it is context-free. Context-sensitive grammars with a quadratic degree of non-context-freeness are more powerful than those of a linear degree.
KW  - context-free grammar
KW  - degree of non-regularity
KW  - context-sensitive
KW  - grammar
KW  - degree of non-context-freeness
Y1  - 2020
U6  - https://doi.org/10.1016/j.jcss.2019.09.003
SN  - 0022-0000
SN  - 1090-2724
VL  - 108
SP  - 104
EP  - 117
PB  - Elsevier
CY  - San Diego, Calif. [u.a.]
ER  - 
TY  - JOUR
A1  - Bordihn, Henning
A1  - Mitrana, Victor
A1  - Paun, Andrei
A1  - Paun, Mihaela
T1  - Hairpin completions and reductions
BT  - semilinearity properties
JF  - Natural computing : an innovative journal bridging biosciences and computer sciences ; an international journal
N2  - This paper is part of the investigation of some operations on words and languages with motivations coming from DNA biochemistry, namely three variants of hairpin completion and three variants of hairpin reduction. Since not all the hairpin completions or reductions of semilinear languages remain semilinear, we study sufficient conditions for semilinear languages to preserve their semilinearity property after applying the non-iterated hairpin completion or hairpin reduction. A similar approach is then applied to the iterated variants of these operations. Along these lines, we define the hairpin reduction root of a language and show that the hairpin reduction root of a semilinear language is not necessarily semilinear except the universal language. A few open problems are finally discussed.
KW  - DNA hairpin formation
KW  - Hairpin completions
KW  - Hairpin reductions
KW  - Semilinearity property
Y1  - 2020
U6  - https://doi.org/10.1007/s11047-020-09797-0
SN  - 1572-9796
VL  - 20
IS  - 2
SP  - 193
EP  - 203
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Bordihn, Henning
A1  - Vaszil, György
T1  - Deterministic Lindenmayer systems with dynamic control of parallelism
JF  - International journal of foundations of computer science
N2  - M-rate 0L systems are interactionless Lindenmayer systems together with a function assigning to every string a set of multisets of productions that may be applied simultaneously to the string. Some questions that have been left open in the forerunner papers are examined, and the computational power of deterministic M-rate 0L systems is investigated, where also tabled and extended variants are taken into consideration.
KW  - parallel rewriting
KW  - Lindenmayer systems
KW  - restricted parallelism
KW  - determinism
KW  - developmental systems
KW  - formal languages
Y1  - 2019
U6  - https://doi.org/10.1142/S0129054120400031
SN  - 0129-0541
SN  - 1793-6373
VL  - 31
IS  - 1
SP  - 37
EP  - 51
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Bornhorst, Julia
A1  - Ebert, Franziska
A1  - Meyer, Sören
A1  - Ziemann, Vanessa
A1  - Xiong, Chan
A1  - Guttenberger, Nikolaus
A1  - Raab, Andrea
A1  - Baesler, Jessica
A1  - Aschner, Michael
A1  - Feldmann, Jörg
A1  - Francesconi, Kevin
A1  - Raber, Georg
A1  - Schwerdtle, Tanja
T1  - Toxicity of three types of arsenolipids
BT  - species-specific effects in Caenorhabditis elegans
JF  - Metallomics
N2  - Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.
Y1  - 2020
U6  - https://doi.org/https://doi.org/10.1039/d0mt00039f
SN  - 1756-591X
SN  - 1756-5901
VL  - 12
IS  - 5
SP  - 794
EP  - 798
PB  - Oxford University Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Borremans, An
A1  - Bußler, Sara
A1  - Sagu Tchewonpi, Sorel
A1  - Rawel, Harshadrai Manilal
A1  - Schlüter, Oliver K.
A1  - Leen, Van Campenhout
T1  - Effect of blanching plus fermentation on selected functional properties of mealworm (Tenebrio molitor) powders
JF  - Foods : open access journal
N2  - The aim of this study was to determine the effect of blanching followed by fermentation of mealworms (Tenebrio molitor) with commercial meat starter cultures on the functional properties of powders produced from the larvae. Full fat and defatted powder samples were prepared from non-fermented and fermented mealworm pastes. Then the crude protein, crude fat, and dry matter contents, pH, bulk density, colour, water and oil binding capacity, foaming capacity and stability, emulsion capacity and stability, protein solubility, quantity of free amino groups, and protein composition of the powders were evaluated. Regardless of the starter culture used, the blanching plus fermentation process reduced the crude and soluble protein contents of the full fat powders and in general impaired their water and oil binding, foaming, and emulsifying properties. Defatting of the powders improved most functional properties studied. The o-phthaldialdehyde assay revealed that the amount of free amino groups was higher in the fermented powders while sodium dodecyl sulfate polyacrylamide gel electrophoresis demonstrated that the soluble proteins of the fermented powders were composed of molecules of lower molecular mass compared to non-fermented powders. As molecular sizes of the soluble proteins decreased, it was clear that the protein structure was also modified by the fermentation process, which in turn led to changes in functional properties. In general, it was concluded that fermentation of mealworms with blanching as a pre-treatment does not contribute to the functional properties studied in this work. Nevertheless, the results confirmed that the properties of non-fermented powders are comparable to other food protein sources.
KW  - mealworm
KW  - fermentation
KW  - functional properties
KW  - insect proteins
KW  - SDS-PAGE
Y1  - 2020
U6  - https://doi.org/10.3390/foods9070917
SN  - 2304-8158
VL  - 9
IS  - 7
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Bosch, Jannis
A1  - Wilbert, Jürgen
T1  - Contrast and Assimilation Effects on Self-Evaluation of Performance and Task Interest in a Sample of Elementary School Children
JF  - Frontiers in Education
N2  - Social comparison processes and the social position within a school class already play a major role in performance evaluation as early as in elementary school. The influence of contrast and assimilation effects on self-evaluation of performance as well as task interest has been widely researched in observational studies under the labels big-fish-little-pond and basking-in-reflected-glory effect. This study examined the influence of similar contrast and assimilation effects in an experimental paradigm. Fifth and sixth grade students (n = 230) completed a computer-based learning task during which they received social comparative feedback based on 2 × 2 experimentally manipulated feedback conditions: social position (high vs. low) and peer performance (high vs. low). Results show a more positive development of task interest and self-evaluation of performance in both the high social position and the high peer performance condition. When applied to the school setting, results of this study suggest that students who already perform well in comparison to their peer group are also the ones who profit most from social comparative feedback, given that they are the ones who usually receive the corresponding positive performance feedback.
KW  - social comparison
KW  - feedback
KW  - self-evaluation
KW  - interest
KW  - contrast effect
Y1  - 2019
U6  - https://doi.org/10.3389/feduc.2019.00165
SN  - 2504-284X
VL  - 4
IS  - 165
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Botero, David
A1  - Monk, Jonathan
A1  - Rodriguez Cubillos, Maria Juliana
A1  - Rodriguez Cubillos, Andres Eduardo
A1  - Restrepo, Mariana
A1  - Bernal-Galeano, Vivian
A1  - Reyes, Alejandro
A1  - Gonzalez Barrios, Andres
A1  - Palsson, Bernhard O.
A1  - Restrepo, Silvia
A1  - Bernal, Adriana
T1  - Genome-scale metabolic model of Xanthomonas phaseoli pv. manihotis
BT  - an approach to elucidate pathogenicity at the metabolic level
JF  - Frontiers in genetics
N2  - Xanthomonas phaseoli pv. manihotis (Xpm) is the causal agent of cassava bacterial blight, the most important bacterial disease in this crop. There is a paucity of knowledge about the metabolism of Xanthomonas and its relevance in the pathogenic process, with the exception of the elucidation of the xanthan biosynthesis route. Here we report the reconstruction of the genome-scale model of Xpm metabolism and the insights it provides into plant-pathogen interactions. The model, iXpm1556, displayed 1,556 reactions, 1,527 compounds, and 890 genes. Metabolic maps of central amino acid and carbohydrate metabolism, as well as xanthan biosynthesis of Xpm, were reconstructed using Escher (https://escher.github.io/) to guide the curation process and for further analyses. The model was constrained using the RNA-seq data of a mutant of Xpm for quorum sensing (QS), and these data were used to construct context-specific models (CSMs) of the metabolism of the two strains (wild type and QS mutant). The CSMs and flux balance analysis were used to get insights into pathogenicity, xanthan biosynthesis, and QS mechanisms. Between the CSMs, 653 reactions were shared; unique reactions belong to purine, pyrimidine, and amino acid metabolism. Alternative objective functions were used to demonstrate a trade-off between xanthan biosynthesis and growth and the re-allocation of resources in the process of biosynthesis. Important features altered by QS included carbohydrate metabolism, NAD(P)(+) balance, and fatty acid elongation. In this work, we modeled the xanthan biosynthesis and the QS process and their impact on the metabolism of the bacterium. This model will be useful for researchers studying host-pathogen interactions and will provide insights into the mechanisms of infection used by this and other Xanthomonas species.
KW  - Xanthomonas
KW  - Xpm
KW  - cassava bacterial blight
KW  - genome-scale metabolic
KW  - model
KW  - quorum sensing
Y1  - 2020
U6  - https://doi.org/10.3389/fgene.2020.00837
SN  - 1664-8021
VL  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bouakline, Foudhil
T1  - Does nuclear permutation symmetry allow dynamical localization in symmetric double-well achiral molecules?
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - We discuss the effect of molecular symmetry on coherent tunneling in symmetric double-well potentials whose two molecular equilibrium configurations are interconverted by nuclear permutations. This is illustrated with vibrational tunneling in ammonia molecules, electronic tunneling in the dihydrogen cation, and laser-induced rotational tunneling of homonuclear diatomics. In this contribution, we reexamine the textbook picture of coherent tunneling in such potentials, which is depicted with a wavepacket shuttling back and forth between the two potential-wells. We show that the common application of this picture to the aforementioned molecules contravenes the principle of the indistinguishability of identical particles. This conflict originates from the sole consideration of the dynamics of the tunneling-mode, connecting the double-well energy minima, and complete omission of all the remaining molecular degrees of freedom. This gives rise to double-well wavepackets that are nonsymmetric under nuclear permutations. To obey quantum statistics, we show that the double-well eigenstates composing these wavepackets must be entangled with the wavefunctions that describe all the omitted molecular modes. These wavefunctions have compensating and opposite nuclear permutation symmetry. This in turn leads to complete quenching of interference effects behind localization in one potential-well or another. Indeed, we demonstrate that the reduced density of probability of the symmetrized molecular wavefunction, where all the molecular coordinates but the tunneling-mode are integrated out, is symmetrically distributed over the two potential-wells, at all times. This applies to any multilevel wavepacket of isotropic or fully aligned symmetric double-well achiral molecules. However, in the case of coherent electronic or vibrational tunneling, fully aligned molecules may exhibit dynamical localization in the space-fixed frame, where the tunneling-mode density shuttles between the opposite directions of the alignment axis. This dynamical spatial-localization results from linear combinations of molecular states that have opposite parity. In summary, this study shows that dynamical localization of the tunneling-mode density on either of the two indistinguishable molecular equilibrium configurations of symmetric double-well achiral molecules is forbidden by quantum statistics, whereas its dynamical localization in the space-fixed frame is allowed by parity. The subtle distinction between these two types of localization has far-reaching implications in the interpretation of many ultrafast molecular dynamics experiments.
Y1  - 2020
U6  - https://doi.org/10.1063/1.5141746
SN  - 0021-9606
SN  - 1089-7690
VL  - 152
IS  - 24
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Bouakline, Foudhil
A1  - Tremblay, Jean Christophe
T1  - Is it really possible to control aromaticity of benzene with light?
JF  - Physical chemistry, chemical physics : PCCP
N2  - Recent theoretical investigations claim that tailored laser pulses may selectively steer benzene's aromatic ground state to localized non-aromatic excited states. For instance, it has been shown that electronic wavepackets, involving the two lowest electronic eigenstates, exhibit subfemtosecond charge oscillation between equivalent Kekule resonance structures. In this contribution, we show that such dynamical electron-localization in the molecule-fixed frame contravenes the principle of the indistinguishability of identical particles. This breach stems from a total omission of the nuclear degrees of freedom, giving rise to nonsymmetric electronic wavepackets under nuclear permutations. Enforcement of the latter leads to entanglement between the electronic and nuclear states. To obey quantum statistics, the entangled molecular states should involve compensating nuclear-permutation symmetries. This in turn engenders complete quenching of dynamical electron-localization in the molecule-fixed frame. Indeed, for the (six-fold) equilibrium geometry of benzene, group-theoretic analysis reveals that any electronic wavepacket exhibits a (D-6h) totally symmetric electronic density, at all times. Thus, our results clearly show that the six carbon atoms, and the six C-C bonds, always have equal Mulliken charges, and equal bond orders, respectively. However, electronic wavepackets may display dynamical localization of the electronic density in the space-fixed frame, whenever they involve both even and odd space-inversion (parity) or permutation-inversion symmetry. Dynamical spatial-localization can be probed experimentally in the laboratory frame, but it should not be deemed equivalent to charge oscillation between benzene's identical electronic substructures, such as Kekule resonance structures.
Y1  - 2020
U6  - https://doi.org/10.1039/c9cp06794a
SN  - 1463-9076
SN  - 1463-9084
VL  - 22
IS  - 27
SP  - 15401
EP  - 15412
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  -