TY - GEN A1 - Rodríguez Sillke, Yasmina A1 - Schumann, Michael A1 - Lissner, Donata A1 - Branchi, Frederica A1 - Glauben, Rainer A1 - Siegmund, Britta T1 - Small intestinal inflammation but not colitis drives pro-inflammatory nutritional antigen-specific T-cell response T2 - Journal of Crohn's and Colitis N2 - Background: Inflammatory bowel disease (IBD) represents a dysregulation of the mucosal immune system. The pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) is linked to the loss of intestinal tolerance and barrier function. The healthy mucosal immune system has previously been shown to be inert against food antigens. Since the small intestine is the main contact surface for antigens and therefore the immunological response, the present study served to analyse food-antigen-specific T cells in the peripheral blood of IBD patients. Methods: Peripheral blood mononuclear cells of CD, with an affected small intestine, and UC (colitis) patients, either active or in remission, were stimulated with the following food antigens: gluten, soybean, peanut and ovalbumin. Healthy controls and celiac disease patients were included as controls. Antigen-activated CD4+ T cells in the peripheral blood were analysed by a magnetic enrichment of CD154+ effector T cells and a cytometric antigen-reactive T-cell analysis (‘ARTE’ technology) followed by characterisation of the ef- fector response. Results: The effector T-cell response of antigen-specific T cells were compared between CD with small intestinal inflammation and UC where inflammation was restricted to the colon. Among all tested food antigens, the highest frequency of antigen-specific T cells (CD4+CD154+) was found for gluten. Celiac disease patients were included as control, since gluten has been identified as the disease- causing antigen. The highest frequency of gluten antigen-specific T cells was revealed in active CD when compared with UC, celiac disease on a gluten-free diet (GFD) and healthy controls. Ovalbuminspecific T cells were almost undetectable, whereas the reaction to soybean and peanut was slightly higher. But again, the strong- est reaction was observed in CD with small intestinal involvement compared with UC. Remarkably, in celiac disease on a GFD only antigen-specific cells for gluten were detected. These gluten-specific T cells were characterised by up-regulation of the pro-inflammatory cytokines IFN-γ, IL-17A and TNF-α. IFN-g was exclusively elevated in CD patients with active disease. Gluten-specific T-cells expressing IL-17A were increased in all IBD patients. Furthermore, T cells of CD patients, independent of disease activity, revealed a high expression of the pro-inflammatory cytokine TNF-α. Conclusion: The ‘ARTE’-technique allows to analyse and quantify food antigen specific T cells in the peripheral blood of IBD patients indicating a potential therapeutic insight. These data provide evidence that small intestinal inflammation in CD is key for the development of a systemic pro-inflammatory effector T-cell response driven by food antigens. Y1 - 2020 U6 - https://doi.org/10.1093/ecco-jcc/jjz203.172 SN - 1873-9946 SN - 1876-4479 VL - 14 SP - S154 EP - S155 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Paoli, Antonio A1 - Moro, Tatiana A1 - Lorenzetti, Silvio A1 - Seiler, Jan A1 - Lüthy, Fabian A1 - Gross, Micah A1 - Roggio, Federico A1 - Chaabene, Helmi A1 - Musumeci, Giuseppe T1 - The “Journal of Functional Morphology and Kinesiology” Journal Club Series BT - Resistance Training T2 - Journal of Functional Morphology and Kinesiology N2 - We are glad to introduce the Second Journal Club of Volume Five, Second Issue. This edition is focused on relevant studies published in the last few years in the field of resistance training, chosen by our Editorial Board members and their colleagues. We hope to stimulate your curiosity in this field and to share with you the passion for the sport, seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture. Y1 - 2020 U6 - https://doi.org/10.3390/jfmk5020025 SN - 2411-5142 VL - 5 IS - 2 SP - 1 EP - 9 PB - MDPI CY - Basel ER - TY - GEN A1 - Otto, Christian A1 - Piontek, Franziska A1 - Kalkuhl, Matthias A1 - Frieler, Katja T1 - Event-based models to understand the scale of the impact of extremes T2 - Nature energy N2 - Climate change entails an intensification of extreme weather events that can potentially trigger socioeconomic and energy system disruptions. As we approach 1 degrees C of global warming we should start learning from historical extremes and explicitly incorporate such events in integrated climate-economy and energy systems models. KW - Climate-change impacts KW - Energy economics KW - Socioeconomic scenarios Y1 - 2020 U6 - https://doi.org/10.1038/s41560-020-0562-4 SN - 2058-7546 VL - 5 IS - 2 SP - 111 EP - 114 PB - Nature Publishing Group CY - London ER - TY - GEN A1 - Nair, Alexandra A1 - Lin, Chiao-I A1 - Khajooei, Mina A1 - Heikkila, Mika A1 - Engel, Tilman A1 - Mayer, Frank T1 - Side comparison of knee muscle activities in response to perturbed walking of unilateral ankle instability T2 - Medicine and science in sports and exercise : MSSE N2 - Acute ankle sprain leads in 40% of all cases to chronic ankle instability (CAI). CAI is related to a variety of motor adaptations at the lower extremities. Previous investigations identified increased muscle activities while landing in CAI compared to healthy control participants. However, it remains unclear whether muscular alterations at the knee muscles are limited to the involved (unstable) ankle or are also present at the uninvolved leg. The latter might potentially indicate a risk of ankle sprain or future injury on the uninvolved leg. Purpose: To assess if there is a difference of knee muscle activities between the involved and uninvolved leg in participants with CAI during perturbed walking. Method: 10 participants (6 females; 4 males; 26±4 years; 169±9 cm; 65±7 kg) with unilateral CAI walked on a split-belt treadmill (1m/s) for 5 minutes of baseline walking and 6 minutes of perturbed walking (left and right side, each 10 perturbations). Electromyography (EMG) measurements were performed at biceps femoris (BF) and rectus femoris (RF). EMG amplitude (RMS; normalized to MVIC) were analyzed for 200ms pre-heel contact (Pre200), 100ms post heel contact (Post100) and 200ms after perturbation (Pert200). Data was analyzed by paired t-test/Wilcoxon test based on presence or absence of normal distribution (Bonferroni adjusted α level p≤ 0.0125). Results: No statistical difference was found between involved and uninvolved leg for RF (Pre200: 4±2% and 11± 22%, respectively, p= 0.878; Post100: 10± 5 and 18±31%, p=0.959; Pert200: 6±3% and 13±24%, p=0.721) as well as for BF (Pre200: 12±7% and 11±6, p=0.576; Post100: 10±7% and 9±7%, p=0.732; Pert200: 7±4 and 7±7%, p=0.386). Discussion: No side differences in muscle activity could be revealed for assessed feedforward and feedback responses (perturbed and unperturbed) in unilateral CAI. Reduced inter-individual variability of muscular activities at the involved leg might indicate a rather stereotypical response pattern. It remains to be investigated, whether muscular control at the knee is not affected by CAI, or whether both sides adapted in a similar style to the chronic condition at the ankle. Y1 - 2020 U6 - https://doi.org/10.1249/01.mss.0000671088.10003.6b SN - 0195-9131 SN - 1530-0315 VL - 52 IS - 17 SP - 97 EP - 97 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - GEN A1 - Moreno-Romero, Jordi A1 - Probst, Aline V. A1 - Trindade, Inês A1 - Kalyanikrishna, A1 - Engelhorn, Julia A1 - Farrona, Sara T1 - Looking At the Past and Heading to the Future BT - Meeting Summary of the 6th European Workshop on Plant Chromatin 2019 in Cologne, Germany T2 - Frontiers in Plant Science N2 - In June 2019, more than a hundred plant researchers met in Cologne, Germany, for the 6th European Workshop on Plant Chromatin (EWPC). This conference brought together a highly dynamic community of researchers with the common aim to understand how chromatin organization controls gene expression, development, and plant responses to the environment. New evidence showing how epigenetic states are set, perpetuated, and inherited were presented, and novel data related to the three-dimensional organization of chromatin within the nucleus were discussed. At the level of the nucleosome, its composition by different histone variants and their specialized histone deposition complexes were addressed as well as the mechanisms involved in histone post-translational modifications and their role in gene expression. The keynote lecture on plant DNA methylation by Julie Law (SALK Institute) and the tribute session to Lars Hennig, honoring the memory of one of the founders of the EWPC who contributed to promote the plant chromatin and epigenetic field in Europe, added a very special note to this gathering. In this perspective article we summarize some of the most outstanding data and advances on plant chromatin research presented at this workshop. KW - EWPC2019 KW - chromatin KW - epigenetics KW - transcription KW - nucleus Y1 - 2020 U6 - https://doi.org/10.3389/fpls.2019.01795 SN - 1664-462X VL - 10 IS - 1795 SP - 1 EP - 12 PB - Frontiers Media CY - Lausanne ER - TY - GEN A1 - Moerschbacher, Bruno A1 - Jaworska, Małgorzata A1 - Peter, Martin G. T1 - Obituary of George A.F. Roberts (1939-2018) T2 - Reactive & functional polymers Y1 - 2020 U6 - https://doi.org/10.1016/j.reactfunctpolym.2020.104711 SN - 1381-5148 SN - 1873-166X VL - 156 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - GEN A1 - Lin, Chiao-I A1 - Khajooei, Mina A1 - Nair, Alexandra A1 - Heikkila, Mika A1 - Kaplick, Hannes A1 - Tilman, Engel A1 - Mayer, Frank T1 - Activities of hip muscles in response to perturbed walking in individual with chronic ankle instability T2 - Medicine and science in sports and exercise : MSSE N2 - Chronic ankle instability (CAI) is not only an ankle issue, but also affects sensorimotor system. People with CAI show altered muscle activation in proximal joints such as hip and knee. However, evidence is limited as controversial results have been presented regarding changes in activation of hip muscles in CAI population. PURPOSE: To investigate the effect of CAI on activity of hip muscles during normal walking and walking with perturbations. METHODS: 8 subjects with CAI (23 ± 2 years, 171 ± 7 cm and 65 ± 4 kg) and 8 controls (CON) matched by age, height, weight and dominant leg (25 ± 3 years, 172 ± 7 cm and 65 ± 6 kg) walked shoed on a split-belt treadmill (1 m/s). Subjects performed 5 minutes of baseline walking and 6 minutes walking with 10 perturbations (at 200 ms after heel contact with 42 m/s2 deceleration impulse) on each side. Electromyography signals from gluteus medius (Gmed) and gluteus maximus (Gmax) were recorded while walking. Muscle amplitudes (Root Mean Square normalized to maximum voluntary isometric contraction) were calculated at 200 ms before heel contact (Pre200), 100 ms after heel contact (Post100) during normal walking and 200 ms after perturbations (Pert200). Differences between groups were examined using Mann Whitney U test and Bonferroni correction to account for multiple testing (adjust α level p≤ 0.0125). RESULT: In Gmed, CAI group showed lower muscle amplitude than CON group after heel contact (Post100: 18±7 % and 47±21 %, p< .01) and after walking perturbations ( 31±13 % and 62±26 %, p< .01), but not before heel contact (Pre200: 5±2 % and 11±10 %, p= 0.195). In Gmax, no difference was found between CAI and CON groups in all three time points (Pre200: 12±5 % and 17±12 %, p= 0.574; Post100: 41±21 % and 41±13 %, p= 1.00; Pert200: 79±46 % and 62±35 %, p= 0.505). CONCLUSION: People with CAI activated Gmed less than healthy control in feedback mechanism (after heel contact and walking with perturbations), but not in feedforward mechanism (before heel contact). Less activation on Gmed may affect the balance in frontal plane and increase the risk of recurrent ankle sprain, giving way or feeling ankle instability in patients with CAI during walking. Future studies should investigate the effect of Gmed strengthening or neuromuscular training on CAI rehabilitation. Y1 - 2020 U6 - https://doi.org/10.1249/01.mss.0000671060.98581.0b SN - 0195-9131 SN - 1530-0315 VL - 52 IS - 17 SP - 94 EP - 94 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - GEN A1 - Kohler, Ulrich T1 - Editorial: Survey Research Methods during the COVID-19 Crisis T2 - Survey Research Methods KW - COVID-19 KW - Survey Research Methods Y1 - 2020 U6 - https://doi.org/10.18148/srm/2020.v14i2.7769 SN - 1864-3361 VL - 14 IS - 2 SP - 93 EP - 94 CY - Konstanz ER - TY - GEN A1 - Joost, Theresa Anna A1 - Brecht, Pia A1 - Mayer, Frank A1 - Cassel, Michael T1 - Feasibility of open low-field MRI measurements in adolescent athletes with spondylolisthesis T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine N2 - PURPOSE: To determine the feasibility of upright compared to supine MRI measurements to determine characteristics of the lumbar spine in AA with spondylolisthesis. METHODS: Ten AA (n=10; m/f: 4/6; 14.5±1.7y; 163±7cm; 52±8kg) from various sports, diagnosed with spondylolisthesis grade I-II Meyerding confirmed by x-ray in standing lateral view, were included. Open low-field MRI images (0.25 Tesla) in upright (82°) and supine (0°) position were evaluated by two observers. Medical imaging software was used to measure the anterior translation (AT, mm), lumbosacral joint angle (LSJA, °) and lordosis angle (LA, °). Reliability was analyzed by the intra-rater correlation coefficient (ICC) and standard error of measurements (SEM). RESULTS: Due to motion artifacts during upright position, measures of three participants had to be excluded. Between observers, AT ranged from 4.2±2.7mm to 5.5±1.9mm (ICC=0.94, SEM=0.6mm) in upright and from 4.9±2.4mm to 5.9±3.0mm (ICC=0.89, SEM=0.9mm) in supine position. LSJA varied from 5.1±2.2° to 7.3±1.5° (ICC=0.54, SEM=1.5°) in upright and from 9.8±2.5° to 10±2.4° (ICC=0.73, SEM=1.1°) in supine position. LA differed from 58.8±14.6° to 61.9±6° (ICC=0.94, SEM=1.19°) in upright and from 51.9±11.7° to 52.6±11.1° (ICC=0.98, SEM=1.59°) in supine position. CONCLUSIONS: Determination of AT and LA showed good to excellent reliability in both, upright and supine position. In contrast, reliability of LSJA had only moderate to good correlation between observers and should therefore be interpreted with caution. However, motion artifacts should be taken into consideration during upright imaging procedures. Y1 - 2020 U6 - https://doi.org/10.1249/01.mss.0000683832.74059.9d SN - 0195-9131 SN - 1530-0315 VL - 52 IS - 17 SP - 790 EP - 790 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - GEN A1 - Jeltsch, Florian A1 - Grimm, Volker T1 - Editorial BT - thematic series "Integrating movement ecology with biodiversity research" T2 - Movement Ecology Y1 - 2020 U6 - https://doi.org/10.1186/s40462-020-00210-0 SN - 2051-3933 VL - 8 IS - 1 PB - BioMed Central CY - London ER - TY - GEN A1 - Jasser, Greta A1 - Kelly, Megan A1 - Rothermel, Ann-Kathrin T1 - Male supremacism and the Hanau terrorist attack BT - between online misogyny and far-right violence Y1 - 2020 UR - https://www.icct.nl/publication/male-supremacism-and-hanau-terrorist-attack-between-online-misogyny-and-far-right PB - International Centre for Counter-Terrorism (ICCT) CY - Den Haag ER - TY - GEN A1 - Hölzle, Katharina A1 - Boer, Harry A1 - Björk, Jennie T1 - Crisis management through creativity and innovation BT - storytelling, moral organizational creativity, and open innovation as creative means to spark innovation T2 - Creativity and innovation management Y1 - 2020 U6 - https://doi.org/10.1111/caim.12385 SN - 0963-1690 SN - 1467-8691 VL - 29 IS - 2 SP - 195 EP - 197 PB - Wiley-Blackwell CY - Oxford [u.a.] ER - TY - GEN A1 - Hermanussen, Michael A1 - Scheffler, Christiane A1 - Pulungan, Aman B. A1 - Batubara, Jose R. L. A1 - Julia, Madarina A1 - Bogin, Barry T1 - Response to the correspondence referring to our article "Stunting is not a synonym of malnutrition" (2018EJCN0997RR) by Conny Tanjung, Titis Prawitasari, Damayanti Rusli Sjarif T2 - European journal of clinical nutrition Y1 - 2020 U6 - https://doi.org/10.1038/s41430-020-0571-1 SN - 0954-3007 SN - 1476-5640 VL - 74 IS - 3 SP - 529 EP - 531 PB - Nature Publ. Group CY - New York, NY ER - TY - GEN A1 - Bürkner, Hans-Joachim T1 - Europeanisation versus Euroscepticism BT - do borders matter? T2 - Geopolitics N2 - Several overlapping crises which affected the EU during the past ten years have recently aggravated. Especially the progressing refugee crisis, the persisting financial crisis and geopolitical turmoil in the EU's neighbourhood contributed to the rise of anti-EU movements and diverse articulations of Euroscepticism. Although public opinion and mainstream political analysis have easily identified right-wing populism as one of the most important drivers, it is still doubtful if it can be equated with Euroscepticism without further ado. To date it is by no means clear how and where Euroscepticism exactly originates. Y1 - 2020 U6 - https://doi.org/10.1080/14650045.2020.1723964 SN - 1465-0045 SN - 1557-3028 VL - 25 IS - 3 SP - 545 EP - 566 PB - Routledge, Taylor & Francis Group CY - Philadelphia, Pa. [u.a] ER - TY - GEN A1 - Braun, Jean T1 - Response to comment by Japsen et al. on "A review of numerical modeling studies of passive margin escarpments leading to a new analytical expression for the rate of escarpment migration velocity" T2 - Gondwana research : international geoscience journal ; official journal of the International Association for Gondwana Research Y1 - 2020 U6 - https://doi.org/10.1016/j.gr.2018.10.003 SN - 1342-937X SN - 1878-0571 VL - 65 SP - 174 EP - 176 PB - Elsevier CY - Amsterdam ER - TY - GEN A1 - Ben Dor, Yoav A1 - Neugebauer, Ina A1 - Enzel, Yehouda A1 - Schwab, Markus J. A1 - Tjallingii, Rik A1 - Erel, Yigal A1 - Brauer, Achim T1 - Reply to comment on: Ben Dor, Yoav et al. : Varves of the Dead Sea sedimentary record. - In: Quaternary science reviews : the international multidisciplinary research and review journal. - 215 (2019), S. 173 - 184. - (ISSN: 0277-3791). - https://doi.org/10.1016/j.quascirev.2019.04.011 T2 - Quaternary science reviews : the international multidisciplinary research and review journal N2 - In the comment on "Varves of the Dead Sea sedimentary record." Quaternary Science Reviews 215 (Ben Dor et al., 2019): 173-184. by R. Bookman, two recently published papers are suggested to prove that the interpretation of the laminated sedimentary sequence of the Dead Sea, deposited mostly during MIS2 and Holocene pluvials, as annual deposits (i.e., varves) is wrong. In the following response, we delineate several lines of evidence which coalesce to demonstrate that based on the vast majority of evidence, including some of the evidence provided in the comment itself, the interpretation of these sediments as varves is the more likely scientific conclusion. We further discuss the evidence brought up in the comment and its irrelevance and lack of robustness for addressing the question under discussion. Y1 - 2020 U6 - https://doi.org/10.1016/j.quascirev.2019.106063 SN - 0277-3791 SN - 1873-457X VL - 231 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - GEN T1 - Research Data Policy and Recommendations for the Handling of Research Data T1 - Forschungsdaten-Policy und Handlungsempfehlungen zum Umgang mit Forschungsdaten N2 - The Research Data Policy of the University of Potsdam has been ratified by Senate on September 25, 2019 and published in Amtliche Bekanntmachungen “Official Notices” September 30, 2019. It applies to all researchers and research support staff. The Recommendations for the Handling of Research Data at the University of Potsdam specify and complement the Research Data Policy of the University of Potsdam. They are aimed at all researchers and research support staff have been adopted by Senate’s Commission for Research and Junior Academics (FNK) on on October 9, 2019. This record provides a non-official translation of both documents from the German original. N2 - Die Forschungsdaten-Policy der Universität Potsdam wurde am 25.09.2019 vom Senat der Universität Potsdam verabschiedet und am 30.09.2019 in den amtlichen Bekanntmachungen veröffentlicht. Sie richten sich an alle wissenschaftlich und forschungsunterstützend tätigen Mitglieder und Angehörigen. Die Handlungsempfehlungen zum Umgang mit Forschungsdaten konkretisieren und ergänzen die Forschungsdaten-Policy der Universität Potsdam. Sie richten sich an alle wissenschaftlich und forschungsunterstützend tätigen Mitglieder und Angehörigen und wurden am 09.10.2019 durch die Kommission für Forschung und wissenschaftlichen Nachwuchs (FNK) angenommen. Bei diesem Dokument handelt es sich um eine nichtoffizielle Übersetzung der beiden deutschsprachigen Originaldokumente. KW - Forschungsdaten KW - Soft Law KW - Universität Potsdam KW - Research Data KW - Soft Law KW - University of Potsdam Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-444385 PB - Universitätsverlag Potsdam CY - Potsdam ET - Version: Oktober 2019 ER -