TY - JOUR A1 - Haralampiev, Ivan A1 - Mertens, Monique A1 - Schwarzer, Roland A1 - Herrmann, Andreas A1 - Volkmer, Rudolf A1 - Wessig, Pablo A1 - Mueller, Peter T1 - Recruitment of SH-Containing peptides to lipid and biological membranes through the use of a palmitic acid functionalized with a Maleimide Group JF - Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition N2 - This study presents a novel and easily applicable approach to recruit sulfhydryl-containing biomolecules to membranes by using a palmitic acid which is functionalized with a maleimide group. Notably, this strategy can also be employed with preformed (biological) membranes. The applicability of the assay is demonstrated by characterizing the binding of a Rhodamine-labeled peptide to lipid and cellular membranes using methods of fluorescence spectroscopy, lifetime measurement, and microscopy. Our approach offers new possibilities for preparing biologically active liposomes and manipulating living cells. KW - liposomes KW - maleimide KW - membranes KW - palmitic acid KW - palmitoylation KW - peptides Y1 - 2015 U6 - https://doi.org/10.1002/anie.201408089 SN - 1433-7851 SN - 1521-3773 VL - 54 IS - 1 SP - 323 EP - 326 PB - Wiley-VCH CY - Weinheim ER - TY - CHAP A1 - Haralampiev, Ivan A1 - Mertens, Monique A1 - Schwarzer, Roland A1 - Herrmann, Andreas A1 - Volkmer, Rudolf A1 - Wessig, Pablo A1 - Müller, Peter T1 - A palmitic acid functionalized with a maleimide group is used to recruit SH-containing peptides to lipid and biological membranes T2 - The FEBS journal Y1 - 2015 SN - 1742-464X SN - 1742-4658 VL - 282 SP - 204 EP - 204 PB - Wiley-Blackwell CY - Hoboken ER - TY - GEN A1 - Klaper, M. A1 - Wessig, Pablo A1 - Linker, Torsten T1 - Base catalysed decomposition of anthracene endoperoxide N2 - Catalytic amounts of a weak base are sufficient to induce the decomposition of anthracene endoperoxides to anthraquinone. The mechanism has been elucidated by isolation of intermediates in combination with DFT calculations. The whole process is suitable for the convenient generation of hydrogen peroxide under very mild conditions. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 219 Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-89676 SP - 1210 EP - 1213 ER - TY - JOUR A1 - Klaper, M. A1 - Wessig, Pablo A1 - Linker, Torsten T1 - Base catalysed decomposition of anthracene endoperoxide JF - Chemical communications : ChemComm N2 - Catalytic amounts of a weak base are sufficient to induce the decomposition of anthracene endoperoxides to anthraquinone. The mechanism has been elucidated by isolation of intermediates in combination with DFT calculations. The whole process is suitable for the convenient generation of hydrogen peroxide under very mild conditions. Y1 - 2015 U6 - https://doi.org/10.1039/C5CC08606J SN - 1364-548X IS - 52 SP - 1210 EP - 1213 PB - Royal Society of Chemistry CY - Cambridge ER - TY - GEN A1 - Pape, Simon A1 - Wessig, Pablo A1 - Brunner, Heiko T1 - A new and environmentally benign synthesis of aroylguanidines using iron trichloride N2 - A new synthetic approach for the guanylation of aroylthioureas using iron trichloride is presented. Our synthetic method distinguishes itself by benign reaction conditions, low costs and a broad product spectrum. The scope of the reaction and calorimetric studies are described. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 308 Y1 - 2015 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102720 SP - 101408 EP - 101411 ER - TY - JOUR A1 - Pape, Simon A1 - Wessig, Pablo A1 - Brunner, Heiko T1 - A new and environmentally benign synthesis of aroylguanidines using iron trichloride JF - RSC Advances N2 - A new synthetic approach for the guanylation of aroylthioureas using iron trichloride is presented. Our synthetic method distinguishes itself by benign reaction conditions, low costs and a broad product spectrum. The scope of the reaction and calorimetric studies are described. Y1 - 2015 U6 - https://doi.org/10.1039/c5ra20869f SN - 2046-2069 VL - 5 IS - 123 SP - 101408 EP - 101411 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Wessig, Pablo A1 - Budach, Dennis B. A1 - Thünemann, Andreas F. T1 - Dendrimers with Oligospiroketal (OSK) Building Blocks: Synthesis and Properties JF - Chemistry - a European journal N2 - The development of novel dendrimers containing oligospiroketal (OSK) rods as building blocks is described. The linkage between the core unit (CU), branching units (BU), and OSK rods relies on the CuAAC reaction between terminal alkynes and azides. Two different strategies of dendrimer synthesis were investigated and it was found that the convergent approach is clearly superior to the divergent one. SAXS measurements and MD simulations indicate that the obtained dendrimer features a globular structure with very low density. Obviously, the OSK rods stabilize a rather loose mass-fractal structure. KW - click chemistry KW - dendrimers KW - molecular rods KW - oxygen heterocycles KW - SAXS Y1 - 2015 U6 - https://doi.org/10.1002/chem.201501386 SN - 0947-6539 SN - 1521-3765 VL - 21 IS - 29 SP - 10466 EP - 10471 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wessig, Pablo A1 - Merkel, Roswitha A1 - Mueller, Peter T1 - Articulated rods - a novel class of molecular rods based on oligospiroketals (OSK) JF - Beilstein journal of organic chemistry N2 - We developed a new type of molecular rods consisting of two (or more) rigid units linked by a flexible joint. Consequently we called these constructs articulated rods (ARs). The syntheses of ARs were carried out by a flexible and modular approach providing access to a number of compounds with various functionalizations in terminal positions. First applications were presented with pyrene, cinnamoyl and anthracenyl labelled ARs. KW - articulated rods KW - click chemistry KW - molecular rods KW - oligospiroketals KW - pyrene excimer Y1 - 2015 U6 - https://doi.org/10.3762/bjoc.11.11 SN - 1860-5397 VL - 11 SP - 74 EP - 84 PB - Beilstein-Institut zur Förderung der Chemischen Wissenschaften CY - Frankfurt, Main ER -