TY - JOUR A1 - Martinez-Ferreiro, Silvia A1 - Reyes, Andres Felipe A1 - Bastiaanse, Roelien T1 - Overcoming discourse-linking difficulties in aphasia BT - the case of clitic pronouns JF - Clinical linguistics & phonetics N2 - The present study aims to contribute to the ongoing discussion about the impact of discourse-linking deficits on the performance of individuals with aphasia by providing new data from a set of rarely investigated constructions: sentences in which a clitic pronoun coexists alongside with the full DP it agrees with. To do so, we use data of individuals with non-fluent aphasias who need to overcome the difficulties in direct object (accusative) clitic production. This results in overproduction of non-target clitic right dislocations (RDs) and clitic doubling (CD). Data from 15 individual’s native speakers of Spanish and Catalan are discussed. Data complement the results of previous investigations on discourse-linking effects in these languages, allowing the interpretation of results across constructions. KW - Clitic pronouns KW - discourse KW - aphasia KW - Spanish KW - Catalan Y1 - 0207 U6 - https://doi.org/10.1080/02699206.2017.1308015 SN - 0269-9206 SN - 1464-5076 VL - 31 IS - 6 SP - 459 EP - 477 PB - Taylor & Francis Group CY - Philadelphia ER - TY - JOUR A1 - Endrejat, Paul C. A1 - Baumgarten, Franz A1 - Kauffeld, Simone T1 - When theory meets practice BT - Combining Lewin’s Ideas about Change with Motivational Interviewing to Increase Energy-Saving Behaviours Within Organizations JF - Journal of Change Management N2 - Although more than seven decades have passed since Lewin laid the foundation for how employees’ behaviour could be changed within organizations, his ideas are far from being obsolescent. Accordingly, this article demonstrates how Lewin’s concepts can still be of use in tackling current issues (i.e. the need to raise energy-saving behaviours within organizations). In order to revive Lewin’s concepts, we combine his approaches on organization change with Motivational Interviewing (MI), a facilitation approach that fits well with his democratic and participatory mind-set. After a theoretical consideration of how Lewin’s ideas could be accompanied by MI principles, we outline a practical concept for raising the level of employees’ energy-saving behaviours to a higher standard. The usefulness of our concept is highlighted on the basis of qualitative (a force field analysis) and quantitative (an increase of energy-saving norms and – behaviours) data. Lewin’s legacy for current organization development, and the theoretical as well as practical implications for how his ideas could be applied through a combination with MI practices, are discussed. KW - Kurt Lewin KW - field theory KW - group dynamics KW - motivational interviewing KW - energy-saving KW - organization development Y1 - 2017 U6 - https://doi.org/10.1080/14697017.2017.1299372 SN - 1469-7017 SN - 1479-1811 VL - 17 IS - 2 SP - 101 EP - 120 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Kubatova, B. A1 - Kubát, Jiří A1 - Hamann, Wolf-Rainer A1 - Oskinova, Lida T1 - Clumping in Massive Star Winds and its Possible Connection to the B[e] Phenomenon T2 - The B(e) Phenomenon: Forty Years of Studies : proceedings of a conference held at Charles University, Prague, Czech Republic, 27 June-1 July 2016 N2 - It has been observationally established that winds of hot massive stars have highly variable characteristics. The variability evident in the winds is believed to be caused by structures on a broad range of spatial scales. Small-scale structures (clumping) in stellar winds of hot stars are possible consequence of an instability appearing in their radiation hydrodynamics. To understand how clumping may influence calculation of theoretical spectra, different clumping properties and their 3D nature have to be taken into account. Properties of clumping have been examined using our 3D radiative transfer calculations. Effects of clumping for the case of the B[e] phenomenon are discussed. Y1 - 2017 SN - 978-1-58381-900-5 SN - 978-1-58381-901-2 VL - 508 SP - 45 EP - 50 PB - Astronomical Soceity of the Pacific CY - San Fransisco ER - TY - GEN A1 - Kurfürst, P. A1 - Feldmeier, Achim A1 - Krtička, Jiri T1 - Modeling sgB[e] Circumstellar Disks T2 - The B(e) Phenomenon: Forty Years of Studies : proceedings of a conference held at Charles University, Prague, Czech Republic, 27 June-1 July 2016 N2 - During their evolution, massive stars are characterized by a significant loss of mass either via spherically symmetric stellar winds or by aspherical mass-loss mechanisms, namely outflowing equatorial disks. However, the scenario that leads to the formation of a disk or rings of gas and dust around these objects is still under debate. Is it a viscous disk or an ouftlowing disk-forming wind or some other mechanism? It is also unclear how various physical mechanisms that act on the circumstellar environment of the stars affect its shape, density, kinematic, and thermal structure. We assume that the disk-forming mechanism is a viscous transport within an equatorial outflowing disk of a rapidly or even critically rotating star. We study the hydrodynamic and thermal structure of optically thick dense parts of outflowing circumstellar disks that may form around,e.g., Be stars, sgB[e] stars, or Pop m stars. We calculate self-consistent time dependent models of the inner dense region of the disk that is strongly affected either by irradiation from the central star and by contributions of viscous heating effects. We also simulate the dynamic effects of collision between expanding ejecta of supernovae and circumstellar disks that may be form in sgB[e] stars and, e.g., LBVs or Pop in stars. Y1 - 2017 UR - https://www.physics.muni.cz/~petrk/presentation.pdf SN - 978-1-58381-900-5 SN - 978-1-58381-901-2 VL - 508 SP - 17 EP - 22 PB - Astronomical Scoeity of the Pacific CY - San Fransisco ER - TY - JOUR A1 - Bleyen, Pieter A1 - Klimovsky, Daniel A1 - Bouckaert, Geert A1 - Reichard, Christoph T1 - Linking budgeting to results? BT - Evidence about performance budgets in European municipalities based on a comparative analytical model JF - Public Management Review N2 - This article contributes to the debate on the incorporation of performance information in European local government budgets. At the core is the development of an analytical model for comparing efforts of performance budgeting (PB). Evidence in ten cases indicates that performance structures and the span of performance differ, that performance indicators are far from always measuring outcomes or outputs, and that future and past performance figures are often absent. Nevertheless similar learning trajectories do exist. Possible explanations for the variation involve the varying degrees of reform implementation, experience with PB and prevailing institutional arrangements. KW - Local government KW - performance budgeting KW - performance information Y1 - 2017 U6 - https://doi.org/10.1080/14719037.2016.1243837 SN - 1471-9037 SN - 1471-9045 VL - 19 IS - 7 SP - 932 EP - 953 PB - Routledge, Taylor & Francis Group CY - London ER - TY - JOUR A1 - Westbury, Michael V. A1 - Dalerumb, Fredrik A1 - Noren, Karin A1 - Hofreiter, Michael T1 - Complete mitochondrial genome of a bat-eared fox (Otocyon megalotis), along with phylogenetic considerations JF - Mitochondrial DNA. Part B N2 - The bat-eared fox, Otocyon megalotis, is the only member of its genus and is thought to occupy a basal position within the dog family. These factors can lead to challenges in complete mitochondrial reconstructions and accurate phylogenetic positioning. Here, we present the first complete mitochondrial genome of the bat-eared fox recovered using shotgun sequencing and iterative mapping to three distantly related species. Phylogenetic analyses placed the bat-eared fox basal in the Canidae family within the clade including true foxes (Vulpes) and the raccoon dog (Nyctereutes) with high support values. This position is in good agreement with previously published results based on short fragments of mitochondrial and nuclear genes, therefore adding more support to the basal positioning of the bat-eared fox within Canidae. KW - Phylogenetics KW - mitochondria KW - iterative mapping KW - Canidae Y1 - 2017 U6 - https://doi.org/10.1080/23802359.2017.1331325 SN - 2380-2359 VL - 2 IS - 1 SP - 298 EP - 299 PB - Routledge, Taylor & Francis Group CY - London ER - TY - JOUR A1 - Sändig, Brigitte T1 - Tragédie et psychologie BT - Camus devant le roman de Faulkner Requiem for a Nun JF - Revue romane : langue et littérature N2 - His dislike for psychological analysis accompanied Albert Camus throughout his life and had a profound impact on his idea of theatre. Especially in his early years, he sees psychology as the antagonist of the kind of theater that he envisages, the "modern tragedy". In the last decade of his life, Camus worked on the novel "Requiem for a Nun" by William Faulkner, whom he greatly respected, in order to stage it. The confrontation with this work and its highly psychologically driven plot makes Camus virtually give up on his anti-psychological attitude. KW - Theater KW - ancient tragedy KW - psychology KW - William Faulkner KW - Albert KW - Camus KW - Requiem for a Nun / Requiem pour une nonne Y1 - 2017 U6 - https://doi.org/10.1075/rro.52.1.07san SN - 0035-3906 SN - 1600-0811 VL - 52 IS - 1 SP - 70 EP - 79 PB - Benjamins CY - Amsterdam ER - TY - GEN A1 - Hocher, Berthold A1 - Yin, Lianghong T1 - Why Current PTH Assays Mislead Clinical Decision Making in Patients with Secondary Hyperparathyroidism T2 - Nephron N2 - Preclinical studies in cell culture systems as well as in whole animal chronic kidney disease (CKD) models showed that parathyroid hormone (PTH), oxidized at the 2 methionine residues (positions 8 and 18), caused a loss of function. This was so far not considered in the development of PTH assays used in current clinical practice. Patients with advanced CKD are subject to oxidative stress, and plasma proteins (including PTH) are targets for oxidants. In patients with CKD, a considerable but variable fraction (about 70 to 90%) of measured PTH appears to be oxidized. Oxidized PTH (oxPTH) does not interact with the PTH receptor resulting in loss of biological activity. Currently used intact PTH (iPTH) assays detect both oxidized and non-oxPTH (n-oxPTH). Clinical studies demonstrated that bioactive, n-oxPTH, but not iPTH nor oxPTH, is associated with mortality in CKD patients. KW - Serum intact-parathyroid hormone level KW - Dialysis patients KW - Mortality Y1 - 2017 U6 - https://doi.org/10.1159/000455289 SN - 1660-8151 SN - 2235-3186 SN - 0028-2766 VL - 136 IS - 2 SP - 137 EP - 142 PB - Karger CY - Basel ER - TY - GEN A1 - Alibabaie, Najmeh A1 - Ghasemzadeh, Mohammad A1 - Meinel, Christoph T1 - A variant of genetic algorithm for non-homogeneous population T2 - International Conference Applied Mathematics, Computational Science and Systems Engineering 2016 N2 - Selection of initial points, the number of clusters and finding proper clusters centers are still the main challenge in clustering processes. In this paper, we suggest genetic algorithm based method which searches several solution spaces simultaneously. The solution spaces are population groups consisting of elements with similar structure. Elements in a group have the same size, while elements in different groups are of different sizes. The proposed algorithm processes the population in groups of chromosomes with one gene, two genes to k genes. These genes hold corresponding information about the cluster centers. In the proposed method, the crossover and mutation operators can accept parents with different sizes; this can lead to versatility in population and information transfer among sub-populations. We implemented the proposed method and evaluated its performance against some random datasets and the Ruspini dataset as well. The experimental results show that the proposed method could effectively determine the appropriate number of clusters and recognize their centers. Overall this research implies that using heterogeneous population in the genetic algorithm can lead to better results. Y1 - 2017 U6 - https://doi.org/10.1051/itmconf/20170902001 SN - 2271-2097 VL - 9 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Schuster, Dirk T1 - European Culture and its Eastern Borders T1 - „Kulturelle Ostgrenzen“ Europas BT - Hans Heinrich Schaeder’s Thinking during the Third Reich BT - Hans Heinrich Schaeders Denken im „Dritten Reich“ JF - Osteuropa N2 - Hans Heinrich Schaeder is considered an important Iranist and historian of religion. For reasons of opportunism, careerism, and anti-Semitic resentment, he used the chance afforded him after the National Socialists seized power in Germany: he combined his historical and philological knowledge with National-Socialist racial ideology. Drawing on the superiority of “Aryanism” he derived from this merger, Schaeder tried to redefine the “Eastern Borders” of “European Culture”. In his concept, Armenians and Persians became integral elements of European culture and history, while Jews and “Semites” were excluded. In academia, publishing, and politics, he put himself at the service of the National-Socialist regime. In his own view, this served the struggle against Communism and the West’s social system. After the war, a de-Nazification commission concluded that there existed no reservations concerning his employment at Göttingen University. N2 - Hans Heinrich Schaeder gilt als bedeutender Iranist und Religionshistoriker. Nach der Machtergreifung der Nationalsozialisten in Deutschland nutzte er aus Opportunismus, Karrierismus und antisemitischem Ressentiment die neuen Chancen: Schaeder verband sein historisches und philologisches Wissen mit der nationalsozialistischen Rassenideologie. Aus der daraus abgeleiteten Überlegenheit des „Ariertums“ definierte er die kulturellen Ostgrenzen Europas neu. Armenier und Perser wurden nun zu integralen Bestandteilen der europäischen Kultur und Geschichte, während er Juden und „Semiten“ aus den Traditionsbeständen ausschloss. Akademisch, publizistisch und politisch stellte er sich in den Dienst des NS-Regimes. In seinem Selbstbild diente das dem Kampf gegen Kommunismus und das westliche Gesellschaftssystem. Nach dem Krieg kam eine Entnazifizierungskommission zu dem Ergebnis, dass gegen seine Beschäftigung an der Universität Göttingen keine Bedenken bestünden. Y1 - 2017 SN - 0030-6428 SN - 2509-3444 VL - 67 IS - 1-2 SP - 121 EP - 130 PB - Berliner Wissenschafts-Verlag CY - Berlin ER - TY - GEN A1 - Lorenz, Claas A1 - Kiekheben, Sebastian A1 - Schnor, Bettina T1 - FaVe: Modeling IPv6 firewalls for fast formal verification T2 - International Conference on Networked Systems (NetSys) 2017 N2 - As virtualization drives the automation of networking, the validation of security properties becomes more and more challenging eventually ruling out manual inspections. While formal verification in Software Defined Networks is provided by comprehensive tools with high speed reverification capabilities like NetPlumber for instance, the presence of middlebox functionality like firewalls is not considered. Also, they lack the ability to handle dynamic protocol elements like IPv6 extension header chains. In this work, we provide suitable modeling abstractions to enable both - the inclusion of firewalls and dynamic protocol elements. We exemplarily model the Linux ip6tables/netfilter packet filter and also provide abstractions for an application layer gateway. Finally, we present a prototype of our formal verification system FaVe. Y1 - 2017 U6 - https://doi.org/10.1109/NetSys.2017.7903956 PB - IEEE CY - New York ER - TY - GEN A1 - Gawron, Marian A1 - Cheng, Feng A1 - Meinel, Christoph T1 - PVD: Passive Vulnerability Detection T2 - 8th International Conference on Information and Communication Systems (ICICS) N2 - The identification of vulnerabilities relies on detailed information about the target infrastructure. The gathering of the necessary information is a crucial step that requires an intensive scanning or mature expertise and knowledge about the system even though the information was already available in a different context. In this paper we propose a new method to detect vulnerabilities that reuses the existing information and eliminates the necessity of a comprehensive scan of the target system. Since our approach is able to identify vulnerabilities without the additional effort of a scan, we are able to increase the overall performance of the detection. Because of the reuse and the removal of the active testing procedures, our approach could be classified as a passive vulnerability detection. We will explain the approach and illustrate the additional possibility to increase the security awareness of users. Therefore, we applied the approach on an experimental setup and extracted security relevant information from web logs. Y1 - 2017 SN - 978-1-5090-4243-2 U6 - https://doi.org/10.1109/IACS.2017.7921992 SN - 2471-125X SP - 322 EP - 327 PB - IEEE CY - New York ER - TY - GEN A1 - Mühlbauer, Felix A1 - Schröder, Lukas A1 - Skoncej, Patryk A1 - Schölzel, Mario T1 - Handling manufacturing and aging faults with software-based techniques in tiny embedded systems T2 - 18th IEEE Latin American Test Symposium (LATS 2017) N2 - Non-volatile memory area occupies a large portion of the area of a chip in an embedded system. Such memories are prone to manufacturing faults, retention faults, and aging faults. The paper presents a single software based technique that allows for handling all of these fault types in tiny embedded systems without the need for hardware support. This is beneficial for low-cost embedded systems with simple memory architectures. A software infrastructure and a flow are presented that demonstrate how the presented technique is used in general for fault handling right after manufacturing and in-the-field. Moreover, a full implementation is presented for a MSP430 microcontroller, along with a discussion of the performance, overhead, and reliability impacts. Y1 - 2027 SN - 978-1-5386-0415-1 U6 - https://doi.org/10.1109/LATW.2017.7906756 PB - IEEE CY - New York ER - TY - GEN A1 - Mühlbauer, Felix A1 - Schröder, Lukas A1 - Schölzel, Mario T1 - On hardware-based fault-handling in dynamically scheduled processors T2 - 20th International Symposium on Design and Diagnostics of Electronic Circuits & Systems (DDECS) 2017 N2 - This paper describes architectural extensions for a dynamically scheduled processor, so that it can be used in three different operation modes, ranging from high-performance, to high-reliability. With minor hardware-extensions of the control path, the resources of the superscalar data-path can be used either for high-performance execution, fail-safe-operation, or fault-tolerant-operation. This makes the processor-architecture a very good candidate for applications with dynamically changing reliability requirements, e.g. for automotive applications. The paper reports the hardware-overhead for the extensions, and investigates the performance penalties introduced by the fail-safe and fault-tolerant mode. Furthermore, a comprehensive fault simulation was carried out in order to investigate the fault-coverage of the proposed approach. Y1 - 2017 SN - 978-1-5386-0472-4 U6 - https://doi.org/10.1109/DDECS.2017.7934572 SN - 2334-3133 SN - 2473-2117 SP - 201 EP - 206 PB - IEEE CY - New York ER - TY - GEN A1 - Malchow, Martin A1 - Renz, Jan A1 - Bauer, Matthias A1 - Meinel, Christoph T1 - Embedded smart home BT - remote lab grading in a MOOC with over 6000 participants T2 - 11th Annual IEEE International Systems Conference (SysCon) N2 - The popularity of MOOCs has increased considerably in the last years. A typical MOOC course consists of video content, self tests after a video and homework, which is normally in multiple choice format. After solving this homeworks for every week of a MOOC, the final exam certificate can be issued when the student has reached a sufficient score. There are also some attempts to include practical tasks, such as programming, in MOOCs for grading. Nevertheless, until now there is no known possibility to teach embedded system programming in a MOOC course where the programming can be done in a remote lab and where grading of the tasks is additionally possible. This embedded programming includes communication over GPIO pins to control LEDs and measure sensor values. We started a MOOC course called "Embedded Smart Home" as a pilot to prove the concept to teach real hardware programming in a MOOC environment under real life MOOC conditions with over 6000 students. Furthermore, also students with real hardware have the possibility to program on their own real hardware and grade their results in the MOOC course. Finally, we evaluate our approach and analyze the student acceptance of this approach to offer a course on embedded programming. We also analyze the hardware usage and working time of students solving tasks to find out if real hardware programming is an advantage and motivating achievement to support students learning success. Y1 - 2017 SN - 978-1-5090-4623-2 U6 - https://doi.org/10.1109/SYSCON.2017.7934728 SN - 1944-7620 SP - 195 EP - 200 PB - IEEE CY - New York ER - TY - GEN A1 - Angerer, Marie-Luise T1 - Moving Forces T2 - The minnesota review N2 - Throughout a large part of the twentieth century, the body was interpreted as a field of signs, the meaning of which pointed to an unconscious dimension. At the height of the popularity of structuralism, Jacques Lacan deemed the unconscious to be “structured like a language.” Starting in the early 1990s, however, a deep shift occurred in the way the body was interpreted. A new movement cast tremendous doubt on the hegemony of language and instead advocated a performative, pictorial, and affective approach — the so-called material turn — which encompassed all of these. In the words of Karen Barad, this turn inquired as to why meaning, history, and truth are assigned to language only, whereas the movements of materiality are given less prominence: “How did language come to be more trustworthy than matter? Why are language and culture granted their own agency and historicity while matter is figured as passive and immutable?” With this shift toward the material, bodies began to be seen in a different light and their materiality understood as something that follows its own laws and movements, which cannot be understood exclusively in terms of social-cultural codes. Instead, these laws and movements call into question the very dichotomies of nature/culture and body/spirit. KW - mattering KW - wondering KW - contingent encounters KW - affect KW - blind feeling KW - sensation Y1 - 2017 U6 - https://doi.org/10.1215/00265667-3787414 SN - 0026-5667 SN - 2157-4189 VL - 88 SP - 83 EP - 95 PB - Duke Univ. Press CY - Durham ER - TY - GEN A1 - Neubauer, Kai A1 - Wanko, Philipp A1 - Schaub, Torsten H. A1 - Haubelt, Christian T1 - Enhancing symbolic system synthesis through ASPmT with partial assignment evaluation T2 - Proceedings of the Design, Automation & Test in Europe Conference & Exhibition (DATE), 2017 N2 - The design of embedded systems is becoming continuously more complex such that efficient system-level design methods are becoming crucial. Recently, combined Answer Set Programming (ASP) and Quantifier Free Integer Difference Logic (QF-IDL) solving has been shown to be a promising approach in system synthesis. However, this approach still has several restrictions limiting its applicability. In the paper at hand, we propose a novel ASP modulo Theories (ASPmT) system synthesis approach, which (i) supports more sophisticated system models, (ii) tightly integrates the QF-IDL solving into the ASP solving, and (iii) makes use of partial assignment checking. As a result, more realistic systems are considered and an early exclusion of infeasible solutions improves the entire system synthesis. Y1 - 2017 SN - 978-3-9815370-9-3 U6 - https://doi.org/10.23919/DATE.2017.7927005 SN - 1530-1591 SP - 306 EP - 309 PB - IEEE CY - New York ER - TY - GEN A1 - Staubitz, Thomas A1 - Wilkins, Christian A1 - Hagedorn, Christiane A1 - Meinel, Christoph T1 - The Gamification of a MOOC Platform T2 - Proceedings of 2017 IEEE Global Engineering Education Conference (EDUCON) N2 - Massive Open Online Courses (MOOCs) have left their mark on the face of education during the recent years. At the Hasso Plattner Institute (HPI) in Potsdam, Germany, we are actively developing a MOOC platform, which provides our research with a plethora of e-learning topics, such as learning analytics, automated assessment, peer assessment, team-work, online proctoring, and gamification. We run several instances of this platform. On openHPI, we provide our own courses from within the HPI context. Further instances are openSAP, openWHO, and mooc.HOUSE, which is the smallest of these platforms, targeting customers with a less extensive course portfolio. In 2013, we started to work on the gamification of our platform. By now, we have implemented about two thirds of the features that we initially have evaluated as useful for our purposes. About a year ago we activated the implemented gamification features on mooc.HOUSE. Before activating the features on openHPI as well, we examined, and re-evaluated our initial considerations based on the data we collected so far and the changes in other contexts of our platforms. KW - MOOC KW - Gamification KW - e-learning KW - Massive Open Online Courses Y1 - 2017 SN - 978-1-5090-5467-1 U6 - https://doi.org/10.1109/EDUCON.2017.7942952 SN - 2165-9567 SP - 883 EP - 892 PB - IEEE CY - New York ER - TY - JOUR A1 - Haag, Johannes T1 - A kantian critique of sellars transcendental realism JF - Wilfrid Sellars, Idealism, and Realism: Understanding Psychological Nominalism Y1 - 2017 SN - 978-1-4742-3895-3 SN - 978-1-4742-3893-9 SN - 978-1-4742-3894-6 SP - 149 EP - 171 PB - Bloomsbury CY - London ER - TY - JOUR A1 - Meer, Frans-Bauke van der A1 - Reichard, Christoph A1 - Ringeling, Arthur T1 - Becoming a Student of Reform JF - Theory and practice of public sector reform Y1 - 2016 SN - 978-1-315-71414-1 SN - 978-1-317-50011-7 SN - 978-1-317-50012-4 VL - 27 SP - 265 EP - 283 PB - Routledge CY - New York ER - TY - CHAP A1 - Schmidt, Marco F. ED - Schmidt, Marco F. T1 - Preface T2 - Drug target miRNA Y1 - 2016 SN - 978-1-4939-6563-2 SN - 978-1-4939-6561-8 U6 - https://doi.org/10.1007/978-1-4939-6563-2 SN - 1064-3745 SN - 1940-6029 VL - 1517 SP - V EP - V PB - Springer CY - New York ER - TY - BOOK ED - Schmidt, Marco F. T1 - Drug target miRNA BT - methods and protocols T3 - Methods in Molecular Biology N2 - This volume provides a concise and technical discussion of recently developed approaches to overcome challenges in miRNA drug discovery. Drug Target miRNA: Methods and Protocols explores strategies to overcome pharmacodynamics and pharmacokinetics challenges. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery. Y1 - 2017 SN - 978-1-4939-6561-8 SN - 978-1-4939-6563-2 U6 - https://doi.org/10.1007/978-1-4939-6563-2 SN - 1064-3745 SN - 1940-6029 PB - Springer CY - New York ER - TY - CHAP A1 - Grum, Marcus A1 - Bender, Benedict A1 - Alfa, Attahiru S. T1 - The construction of a common objective function for analytical infrastructures T2 - 2017 International Conference on Engineering, Technology and Innovation (ICE/ITMC) N2 - The paper deals with the increasing growth of embedded systems and their role within structures similar to the Internet (Internet of Things) as those that provide calculating power and are more or less appropriate for analytical tasks. Faced with the example of a cyber-physical manufacturing system, a common objective function is developed with the intention to measure efficient task processing within analytical infrastructures. A first validation is realized on base of an expert panel. KW - Analytic Infrastructures KW - Cyber-Physical Manufacturing Systems KW - Measuring Efficient Task Processing Y1 - 2018 U6 - https://doi.org/10.1109/ICE.2017.8279892 SP - 219 EP - 225 PB - IEEE CY - New York ER - TY - CHAP A1 - Schlosser, Rainer A1 - Boissier, Martin ED - Liberatore, Federico ED - Parlier, Greg H. ED - Demange, Marc T1 - Optimal price reaction strategies in the presence of active and passive competitors T2 - Proceedings of the 6th International Conference on Operations Research and Enterprise Systems - ICORES N2 - Many markets are characterized by pricing competition. Typically, competitors are involved that adjust their prices in response to other competitors with different frequencies. We analyze stochastic dynamic pricing models under competition for the sale of durable goods. Given a competitor’s pricing strategy, we show how to derive optimal response strategies that take the anticipated competitor’s price adjustments into account. We study resulting price cycles and the associated expected long-term profits. We show that reaction frequencies have a major impact on a strategy’s performance. In order not to act predictable our model also allows to include randomized reaction times. Additionally, we study to which extent optimal response strategies of active competitors are affected by additional passive competitors that use constant prices. It turns out that optimized feedback strategies effectively avoid a decline in price. They help to gain profits, especially, when aggressive competitor s are involved. KW - Dynamic Pricing KW - Competition KW - Optimal Control KW - Response Strategies KW - Reaction Time KW - Price Cycles Y1 - 2017 SN - 978-989-758-218-9 U6 - https://doi.org/10.5220/0006118200470056 SP - 47 EP - 56 PB - SCITEPRESS - Science and Technology Publications, Lda. CY - Setúbal ER - TY - CHAP A1 - Bender, Benedict A1 - Gronau, Norbert T1 - Coring on Digital Platforms BT - Fundamentals and Examples from the Mobile Device Sector T2 - Proceedings of the 38th International Conference on Information Systems (ICIS) N2 - Today’s mobile devices are part of powerful business ecosystems, which usually involve digital platforms. To better understand the complex phenomenon of coring and related dynamics, this paper presents a case study comparing iMessage as part of Apple’s iOS and WhatsApp. Specifically, it investigates activities regarding platform coring, as the integration of several functionalities provided by third-party applications in the platform core. The paper makes three contributions. First, a systematization of coring activities is developed. Coring modes are differentiated by the amount of coring and application maintenance. Second, the case study revealed that the phenomenon of platform coring is present on digital platforms for mobile devices. Third, the fundamentals of coring are discussed as a first step towards theoretical development. Even though coring constitutes a potential threat for third-party developers regarding their functional differentiation, an idea of what a beneficial partnership incorporating coring activities could look like is developed here. KW - Coring KW - Digital Platforms KW - Digital Marketplaces KW - Mobile Software Ecosystems Y1 - 2017 UR - https://aisel.aisnet.org/icis2017/DigitalPlatforms/Presentations/6/ SN - 978-0-9966831-5-9 IS - 8 SP - 5256 EP - 5274 PB - Association for Information Systems (AIS) CY - Atlanta ER - TY - JOUR A1 - Bareither, Nils A1 - Scheffel, Andre A1 - Metz, Johannes T1 - Distribution of polyploid plants in the common annual Brachypodium distachyon (s.l.) in Israel is not linearly correlated with aridity JF - Israel Journal of Plant Sciences N2 - The ecological benefits of polyploidy are intensely debated. Some authors argue that plants with duplicated chromosome sets (polyploids) are more stress- resistant and superior colonizers and may thus outnumber their low ploidy conspecifics in more extreme habitats. Brachypodium distachyon (sensu lato), for example, a common annual grass in Israel and the entire Mediterranean basin, comprises three cytotypes of differing chromosome numbers that were recently proposed as distinct species. It was suggested that increased aridity increases the occurrence of its polyploid cytotype. Here, we tested at two spatial scales whether polyploid plants of B. distachyon s. l. are more frequently found in drier habitats in Israel. We collected a total of 430 specimens (i) along a largescale climatic gradient with 15 thoroughly selected sites (spanning 114- 954 mm annual rainfall), and (ii) from corresponding Northern (more mesic) and Southern (more arid) hill slopes to assess the micro- climatic difference between contrasting exposures. Cytotypes were then determined via flow cytometry. Polyploid plants comprised 90% of all specimens and their proportion ranged between 0% and 100% per site. However, this proportion was not correlated with aridity along the large- scale gradient, nor were polyploids more frequently found on Southern exposures. Our results show for both spatial scales that increasing aridity is not the principal driver for the distribution of polyploids in B. distachyon s. l. in Israel. Notably, though, diploid plants were restricted essentially to four intermediate sites, while polyploids dominated the most arid and the most mesic sites. This, to some degree, clustered pattern suggests that the distribution of cytotypes is not entirely random and calls for future studies to assess further potential drivers. KW - Aridity KW - Brachypodium distachyon KW - Brachypodium hybridum KW - Brachypodium stacei KW - cytotype KW - exposition KW - Israel KW - Mediterranean grass species KW - polyploidization KW - rainfall gradient KW - slope aspect Y1 - 2017 SN - 0792-9978 SN - 2223-8980 VL - 64 SP - 83 EP - 92 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Dereudre, David A1 - Mazzonetto, Sara A1 - Roelly, Sylvie T1 - Exact simulation of Brownian diffusions with drift admitting jumps JF - SIAM journal on scientific computing N2 - In this paper, using an algorithm based on the retrospective rejection sampling scheme introduced in [A. Beskos, O. Papaspiliopoulos, and G. O. Roberts,Methodol. Comput. Appl. Probab., 10 (2008), pp. 85-104] and [P. Etore and M. Martinez, ESAIM Probab.Stat., 18 (2014), pp. 686-702], we propose an exact simulation of a Brownian di ff usion whose drift admits several jumps. We treat explicitly and extensively the case of two jumps, providing numerical simulations. Our main contribution is to manage the technical di ffi culty due to the presence of t w o jumps thanks to a new explicit expression of the transition density of the skew Brownian motion with two semipermeable barriers and a constant drift. KW - exact simulation methods KW - skew Brownian motion KW - skew diffusions KW - Brownian motion with discontinuous drift Y1 - 2017 U6 - https://doi.org/10.1137/16M107699X SN - 1064-8275 SN - 1095-7197 VL - 39 IS - 3 SP - A711 EP - A740 PB - Society for Industrial and Applied Mathematics CY - Philadelphia ER - TY - CHAP A1 - Bookhagen, Bodo ED - Prins, Herbert H.T. ED - Namgail, Tsewang T1 - The influence of hydrology and glaciology on wetlands in the Himalayas T2 - Bird migration across the Himalayas : wetland functioning amidst mountains and glaciers N2 - Birds migrating across the Himalayan region fly over the highest peaks in the world, facing immense physiological and climatic challenges. The authors show the different strategies used by birds to cope with these challenges. Many wetland avian species are seen in the high-altitude lakes of the Himalayas and the adjoining Tibetan Plateau, such as Bar-Headed Geese. Ringing programmes have generated information about origins and destinations, and this book is the first to present information on the bird's exact migratory paths. Capitalising on knowledge generated through satellite telemetry, the authors describe the migratory routes of a multitude of birds flying over or skirting the Himalayas. The myriad of threats to migratory birds and the wetland system in the Central Asian Flyway are discussed, with ways to mitigate them. This volume will inform and persuade policy-makers and conservation practitioners to take appropriate measures for the long-term survival of this unique migration Y1 - 2017 SN - 978-1-107-11471-5 SN - 978-1-316-33542-0 U6 - https://doi.org/10.1017/9781316335420 SP - 175 EP - 188 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - García-Camacho, Raúl A1 - Metz, Johannes A1 - Bilton, Mark C. A1 - Tielboerger, Katja T1 - Phylogenetic structure of annual plant communities along an aridity gradient BT - Interacting effects of habitat filtering and shifting plant-plant interactions JF - Israel Journal of Plant Sciences N2 - The phylogenetic structure of communities (PSC) reveals how evolutionary history affects community assembly processes. However, there are important knowledge gaps on PSC patterns for annual communities and there is a need for studies along environmental gradients in dry ecosystems where several processes shape PSC. Here, we investigated the PSC of annual plants along an aridity gradient in Israel, including eight years, two spatial scales, the effects of shrubs on understory, and the phylogenetic signal of important traits. Increasing drought stress led to overdispersed PSC at the drier end of the gradient, indicating that species were less related than expected by chance. This was supported at a smaller spatial scale, where within the drier sites, communities in open- more arid- habitats were more overdispersed than those under nurse shrubs. Interestingly, some key traits related to drought resistance were not conserved in the phylogeny. Together, our findings suggested that while habitat filtering selected for drought resistance strategies, these strategies evolved independently along multiple contrasting evolutionary lineages. Our comprehensive PSC study provides strong evidence for the interacting effects of habitat filtering and plant- plant interactions, particularly highlighting that the conservative evolution of traits should not be assumed in future interpretations of PSC patterns. KW - Annuals KW - aridity gradient KW - community assembly rules KW - community phylogenetics KW - stress-gradient hypothesis KW - trait phylogenetic conservatism Y1 - 2017 U6 - https://doi.org/10.1080/07929978.2017.1288477 SN - 0792-9978 SN - 2223-8980 VL - 64 IS - 1-2 SP - 122 EP - 134 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Brechenmacher, Thomas A1 - Delgado, Mariano T1 - Re-formation - zu einem Strukturprinzip der Christentums- und Religionsgeschichte BT - Kurzer Sektionsüberblick JF - Historisches Jahrbuch Y1 - 2017 SN - 978-3-495-45294-3 SN - 0018-2621 VL - 137 SP - 3 EP - 6 PB - Alber CY - Freiburg, Breisgau ER - TY - JOUR A1 - Ehrensperger, Kathy T1 - Trajectories and future avenues in Pauline Studies and Jewish–Christian relations BT - the relevance of William S. Campbell’s approach to Paul JF - Journal of beliefs and values : studies in religion & education N2 - William S. Campbell’s research on the apostle Paul has been at the forefront of overcoming anti-Jewish interpretations. His career has been characterised by academic rigour and social and interfaith engagement. His interpretive approach is committed to formulating Christian identity in positive relation to others and thus contributes to provide a vital basis for Jewish-Christian and Interfaith relations in general for the future. KW - Pauline studies KW - Christian identity KW - diversity KW - anti-judaism KW - Jewish-Christian relations KW - interfaith relations Y1 - 2017 U6 - https://doi.org/10.1080/13617672.2017.1314988 SN - 1361-7672 SN - 1469-9362 VL - 38 IS - 2 SP - 153 EP - 158 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Herbst, Uta A1 - Kemmerling, Birte Christina A1 - Neale, Margaret A. T1 - All in, one-at-a-time or somewhere in the middle? BT - Leveraging the composition and size of the negotiating package JF - The journal of business & industrial marketing N2 - Purpose: While industrial marketers have long bundled their products and services to sell them as packages, to what extent should negotiators also rely on packaging their offers? Clearly, negotiating at a package level can tax the cognitive capacity of the involved parties at some point. Therefore, this study aims to analyze the impact of the number and type of issues that should be negotiated simultaneously to leverage the package strategy efficiently and effectively in multi-issue buyer-seller negotiations. Design/methodology/approach: The authors conducted and analyzed negotiation simulations with 676 students from 2 public universities. Findings: The authors’ results suggest that negotiating three out of six issues simultaneously is the least efficient but most effective strategy in multi-issue buyer-seller negotiations. Moreover, they found that bundling distributive and integrative issues is more efficient and effective than only bundling distributive or integrative negotiation issues in a package offer. Originality/value: Past research has examined the impact of negotiating a package as compared to each issue separately; however, little empirical attention has been directed toward understanding how to apply a package strategy in complex multi-issue negotiations. KW - Negotiation performance KW - Issue bundling KW - Joint negotiation outcome KW - Number of offers KW - Package strategy Y1 - 2017 U6 - https://doi.org/10.1108/JBIM-12-2015-0251 SN - 0885-8624 SN - 2052-1189 VL - 32 IS - 4 SP - 580 EP - 586 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Homolka, Walter T1 - Truthfulness and the permissibility of falsehood in the Jewish tradition JF - Journal of beliefs and values : studies in religion & education N2 - In this article, I deal with the concept of truth and lie in Jewish traditional literature, examining its development in the Hebrew Bible and rabbinic literature. An essential aspect in understanding this concept is the dualism of ‘good’ and ‘evil’ impulses and the free will of human beings, who were created in the image of God and have the choice to decide between right and wrong. KW - sin KW - Truthfulness KW - falsehood KW - Jewish tradition KW - lie KW - free will KW - God’s image Y1 - 2017 U6 - https://doi.org/10.1080/13617672.2017.1291253 SN - 1361-7672 SN - 1469-9362 VL - 38 IS - 2 SP - 180 EP - 187 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Acevedo, Walter A1 - De Wiljes, Jana A1 - Reich, Sebastian T1 - Second-order accurate ensemble transform particle filters JF - SIAM journal on scientific computing N2 - Particle filters (also called sequential Monte Carlo methods) are widely used for state and parameter estimation problems in the context of nonlinear evolution equations. The recently proposed ensemble transform particle filter (ETPF) [S. Reich, SIAM T. Sci. Comput., 35, (2013), pp. A2013-A2014[ replaces the resampling step of a standard particle filter by a linear transformation which allows for a hybridization of particle filters with ensemble Kalman filters and renders the resulting hybrid filters applicable to spatially extended systems. However, the linear transformation step is computationally expensive and leads to an underestimation of the ensemble spread for small and moderate ensemble sizes. Here we address both of these shortcomings by developing second order accurate extensions of the ETPF. These extensions allow one in particular to replace the exact solution of a linear transport problem by its Sinkhorn approximation. It is also demonstrated that the nonlinear ensemble transform filter arises as a special case of our general framework. We illustrate the performance of the second-order accurate filters for the chaotic Lorenz-63 and Lorenz-96 models and a dynamic scene-viewing model. The numerical results for the Lorenz-63 and Lorenz-96 models demonstrate that significant accuracy improvements can be achieved in comparison to a standard ensemble Kalman filter and the ETPF for small to moderate ensemble sizes. The numerical results for the scene-viewing model reveal, on the other hand, that second-order corrections can lead to statistically inconsistent samples from the posterior parameter distribution. KW - Bayesian inference KW - data assimilation KW - particle filter KW - ensemble Kalman filter KW - Sinkhorn approximation Y1 - 2017 U6 - https://doi.org/10.1137/16M1095184 SN - 1064-8275 SN - 1095-7197 SN - 2168-3417 VL - 39 IS - 5 SP - A1834 EP - A1850 PB - Society for Industrial and Applied Mathematics CY - Philadelphia ER - TY - JOUR A1 - Schorsch, Jonathan T1 - Modern Angels, Avant-Gardes and the Esoteric Archive JF - Lux in Tenebris : The Visual and the Symbolic in Western Esotericism Y1 - 2016 SN - 978-90-04-33495-3 SN - 978-90-04-33494-6 U6 - https://doi.org/10.1163/9789004334953_018 SN - 1871-1405 VL - 23 SP - 397 EP - 424 PB - Brill CY - Leiden ER - TY - JOUR A1 - Kunow, Rüdiger T1 - The biology of geography disease disease and disease ecologies in the Americas JF - The Routledge companion to inter-American studies Y1 - 2017 SN - 978-1-315-64498-1 SN - 978-1-138-18467-1 SP - 296 EP - 307 PB - Routledge CY - Abingdon ER - TY - JOUR A1 - Ludwig, Joachim T1 - A subject-theoretical perspective on transformative learning and transformative Bildung BT - Transformative Bildung as a Research Strategy on the Processes of Bildung JF - Transformative learning meets Bildung : an international exchange N2 - The German theory on transformative Bildung (Koller, Marotzki, & Sanders, 2007; Koller, 2012; Nohl, 2014) deals with transformation processes in human thinking. Bildung is defined as self and world reference, causing change in the fundamental orientation of people in the course of their biography. Y1 - 2017 SN - 978-94-6300-795-5 SN - 978-94-6300-796-2 SN - 978-94-6300-797-9 U6 - https://doi.org/10.1007/978-94-6300-797-9_4 VL - 21 SP - 43 EP - 55 PB - Sense Publishers CY - Rotterdam ER - TY - JOUR A1 - Lange, Jerome A1 - Schumacher, Reinhard A1 - Svorencik, Andrej T1 - From antiquity to modern macro BT - an overview of contemporary scholarship in the history of economic thought journals, 2015-2016 JF - History of economic ideas N2 - This survey provides an overview of topics related to the history of economics that have been discussed within the last two years in journal articles. The survey format has been started by History of Economic Ideas last year with the survey by Giulia Bianchi (2016) and is aimed to increase the visibility of research in the history of economics. The emphasis of our survey is on the big three journals in the history of economics: the European Journal of the History of Economic Thought, the Journal of the History of Economic Thought and History of Political Economy. We also included additional journals that frequently publish articles related to the history of economics. These include, in alphabetical order, the Cambridge Journal of Economics, Contributions to Political Economy, Economic Thought, the Erasmus Journal for Philosophy and Economics, History of Economic Thought and Policy, the History of Economics Review, the Journal of Economic Literature, the Journal of Economic Methodology, the Journal of Economic Perspectives, OE conomia, Oxford Economic Papers and Research in the History of Economic Thought and Methodology. KW - History of economics KW - survey of literature KW - preclassical economics KW - classical economics KW - 20th-century economics Y1 - 2017 UR - http://digital.casalini.it/10.19272/201706102007 U6 - https://doi.org/10.19272/201706102007 SN - 1122-8792 SN - 1724-2169 VL - 25 IS - 2 SP - 171 EP - 205 PB - Fabrizio Serra Editore CY - Pisa ER - TY - GEN A1 - Thoelert, Steffen A1 - Hörmann, Ulrich A1 - Antreich, Felix A1 - Meurer, Michael T1 - Ionospheric effects on high gain antenna GNSS measurements BT - TEC estimation and correction T2 - Proceedings of the 30th International Technical Meeting of the Satellite Division of The Institute of Navigation (ION GNSS+ 2017) N2 - The ionospheric delay of global navigation satellite systems (GNSS) signals typically is compensated by adding a single correction value to the pseudorange measurement of a GNSS receiver. Yet, this neglects the dispersive nature of the ionosphere. In this context we analyze the ionospheric signal distortion beyond a constant delay. These effects become increasingly significant with the signal bandwidth and hence more important for new broadband navigation signals. Using measurements of the Galileo E5 signal, captured with a high gain antenna, we verify that the expected influence can indeed be observed and compensated. A new method to estimate the total electron content (TEC) from a single frequency high gain antenna measurement of a broadband GNSS signal is proposed and described in detail. The received signal is de facto unaffected by multi-path and interference because of the narrow aperture angle of the used antenna which should reduce the error source of the result in general. We would like to point out that such measurements are independent of code correlation, like in standard receiver applications. It is therefore also usable without knowledge of the signal coding. Results of the TEC estimation process are shown and discussed comparing to common TEC products like TEC maps and dual frequency receiver estimates. Y1 - 2017 U6 - https://doi.org/10.33012/2017.15343 SN - 2331-5911 SN - 2331-5954 SP - 3368 EP - 3374 PB - Instituite of Navigation CY - Washington ER - TY - JOUR A1 - Wyrwa, Ulrich T1 - Zum Hundertsten nichts Neues T1 - For the Hundredth nothing BT - Deutschsprachige Neuerscheinungen zum Ersten Weltkrieg (Teil III) BT - New German Language New Releases to the First World War (Part III) JF - Deutsche Zeitschrift für Geschichtswissenschaft Y1 - 2017 SN - 0044-2828 VL - 65 IS - 11 SP - 955 EP - 976 PB - Metropol-Verl. CY - Berlin ER - TY - GEN A1 - Laubrock, Jochen A1 - Engbert, Ralf A1 - Cajar, Anke T1 - Gaze-contingent manipulation of the FVF demonstrates the importance of fixation duration for explaining search behavior T2 - Behavioral and brain sciences : an international journal of current research and theory with open peer commentary N2 - Hulleman & Olivers' (H&O's) model introduces variation of the functional visual field (FVF) for explaining visual search behavior. Our research shows how the FVF can be studied using gaze-contingent displays and how FVF variation can be implemented in models of gaze control. Contrary to H&O, we believe that fixation duration is an important factor when modeling visual search behavior. Y1 - 2017 U6 - https://doi.org/10.1017/S0140525X16000145 SN - 0140-525X SN - 1469-1825 VL - 40 SP - 31 EP - 32 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Hörmann, Simon A1 - dos Santos, Luara Ferreira A1 - Morkisch, Nadine A1 - Jettkowski, Katrin A1 - Sillis, Moran A1 - Devan, Hemakumar A1 - Kanagasabai, Parimala S. A1 - Schmidt, Henning A1 - Krüger, Jörg A1 - Dohle, Christian A1 - Regenbrecht, Holger A1 - Hale, Leigh A1 - Cutfield, Nicholas J. T1 - Computerised mirror therapy with Augmented Reflection Technology for early stroke rehabilitation BT - clinical feasibility and integration as an adjunct therapy JF - Disability and rehabilitation : an international, multidisciplinary journal N2 - Purpose: New rehabilitation strategies for post-stroke upper limb rehabilitation employing visual stimulation show promising results, however, cost-efficient and clinically feasible ways to provide these interventions are still lacking. An integral step is to translate recent technological advances, such as in virtual and augmented reality, into therapeutic practice to improve outcomes for patients. This requires research on the adaptation of the technology for clinical use as well as on the appropriate guidelines and protocols for sustainable integration into therapeutic routines. Here, we present and evaluate a novel and affordable augmented reality system (Augmented Reflection Technology, ART) in combination with a validated mirror therapy protocol for upper limb rehabilitation after stroke. Results: The results showed that the combination and application of the Berlin Protocol for Mirror Therapy together with ART was feasible for clinical use. This combination was integrated into the therapeutic plan of subacute stroke patients at the two clinical locations where the second part of this research was conducted. Conclusions: Our findings pave the way for using technology to provide mirror therapy in clinical settings and show potential for the more effective use of inpatient time and enhanced recoveries for patients. IMPLICATIONS FOR REHABILITATION Computerised Mirror Therapy is feasible for clinical use Augmented Reflection Technology can be integrated as an adjunctive therapeutic intervention for subacute stroke patients in an inpatient setting Virtual Rehabilitation devices such as Augmented Reflection Technology have considerable potential to enhance stroke rehabilitation KW - Augmented reality KW - virtual reality KW - usability KW - user experience KW - upper limb KW - visual illusion Y1 - 2017 U6 - https://doi.org/10.1080/09638288.2017.1291765 SN - 0963-8288 SN - 1464-5165 VL - 39 SP - 1503 EP - 1514 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Falk, Thomas A1 - Kirk, Michael A1 - Lohmann, Dirk A1 - Kruger, Bertus A1 - Hüttich, Christian A1 - Kamukuenjandje, Richard T1 - The profits of excludability and transferability in redistributive land reform in central Namibia JF - Development Southern Africa N2 - Policies which redistribute property rights to land can improve the well-being of rural households and can have overall growth effects. In many cases, however, land reforms are driven mainly by politically justified objectives. Under such circumstances, little emphasis is placed on whether and, if so, how property rights can increase productivity. Following 18 years of land reform implementation in Namibia, we evaluated 65 beneficiaries in Namibia. We assess to which degree land rights affects their farm income. The study focuses on Namibia’s two main commercial land reform instruments, namely the Farm Unit Resettlement Scheme and the Affirmative Action Loan Scheme. We find evidence that the majority of land reform projects are not profitable. Further, our study confirms the importance of the right to restrict land access compared with the right to transfer. The long-term leasehold contract seemingly provides sufficient incentives to make productive use of the land. KW - Redistributive land reform KW - property rights KW - farm productivity KW - pastoralism KW - Namibia Y1 - 2017 U6 - https://doi.org/10.1080/0376835X.2016.1269633 SN - 0376-835X SN - 1470-3637 VL - 34 SP - 314 EP - 329 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - McElvenny, James T1 - Grammar, typology and the Humboldtian tradition in the work of Georg von der Gabelentz JF - Language & history : journal of the Henry Sweet Society for the History of Linguistic Ideas N2 - A frequently mentioned if somewhat peripheral figure in the historiography of late nineteenth-century linguistics is the German sinologist and general linguist Georg von der Gabelentz (1840–1893). Today Gabelentz is chiefly remembered for several insights that proved to be productive in the development of subsequent schools and subdisciplines. In this paper, we examine two of these insights, his analytic and synthetic systems of grammar and his foundational work on typology. We show how they were intimately connected within his conception of linguistic research, and how this was in turn embedded in the tradition established by Wilhelm von Humboldt (1767–1835), especially as it was further developed by H. Steinthal (1823–1899). This paper goes beyond several previous works with a similar focus by drawing on a wider range of Gabelentz’ writings, including manuscript sources that have only recently been published, and by examining specific textual connections between Gabelentz and his predecessors. KW - History of linguistics KW - typology KW - language description KW - grammar KW - Humboldtian linguistics KW - Georg von der Gabelentz KW - H . Steinthal KW - Wilhelm von Humboldt Y1 - 2017 U6 - https://doi.org/10.1080/17597536.2016.1212580 SN - 1759-7536 SN - 1759-7544 VL - 60 SP - 1 EP - 20 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Prieto, Julio T1 - From blind shorthand T1 - de la ciega taquigrafía BT - the elusive erudition of Luis Chitarroni BT - la elusiva erudición de Luis Chitarroni JF - Cahiers de LIRICO N2 - This essay explores the poetics of obscurity that informs Luis Chitarroni’s « unfinished novel » The No Variations. Focusing on the « reticent » erudition that distinguishes this text, my analysis examines its dialogue with the paradigm of Borges’ erudition and narrative poetics, as well as with certain « counter-Borgesian » constellations in recent Argentine literature. My reading aims to show how Chitarroni’s anti-novel reactivates a specific Argentinean tradition of productive illegibility while considering how it relates to the practices of « impediment » and « aesthetic reduction » that pervade modern art and literature. N2 - Este ensayo explora la poética de la opacidad en la escritura de Luis Chitarroni y en particular en su « novela inconclusa » Peripecias del no. El análisis se enfoca en la erudición « denegante » que distingue a este texto, y en su diálogo con el modelo de la erudición borgiana y con su poética narrativa, así como con una serie de líneas « contraborgianas » en la literatura argentina reciente. Mi lectura se orienta a mostrar cómo la anti-novela de Chitarroni reactiva una específica tradición literaria argentina de poéticas de lo ilegible a la vez que enlaza con las prácticas del « impedimento » y de la « reducción estética » que recorren la modernidad artística y literaria. N2 - Cet article explore la poétique de la opacité mise en jeu par Luis Chitarroni dans son « roman inachevé » Aventures du Non. À partir d’une analyse de l’érudition « reticente » inhérente à ce texte, j’examine le dialogue que Chitarroni établit avec le modèle de l’érudition borgésienne et sa poétique du récit, ainsi qu’avec une série de lignes narratives « post-borgésiennes » dans la littérature argentine récente. Ma lecture vise à montrer comment l’« anti-roman » de Chitarroni réactive une particulière tradition littéraire argentine relative aux poétiques de l’illisible tout en se liant à la fois avec les pratiques de l’« empêchement » narratif et de la « réduction esthétique » qui traversent la modernité artistique et littéraire. KW - poetics of the illegible KW - hermeticism KW - Chitarroni KW - Borges KW - modern art Y1 - 2017 UR - http://journals.openedition.org/lirico/3807 U6 - https://doi.org/10.4000/lirico.3807 SN - 2263-2158 SN - 2262-8339 PB - Universität de Paris CY - Saint-Denis ER - TY - GEN A1 - Fabian, Benjamin A1 - Baumann, Annika A1 - Ehlert, Mathias A1 - Ververis, Vasilis A1 - Ermakova, Tatiana T1 - CORIA - Analyzing internet connectivity risks using network graphs T2 - 2017 IEEE International Conference on Communications (ICC) N2 - The Internet can be considered as the most important infrastructure for modern society and businesses. A loss of Internet connectivity has strong negative financial impacts for businesses and economies. Therefore, assessing Internet connectivity, in particular beyond their own premises and area of direct control, is of growing importance in the face of potential failures, accidents, and malicious attacks. This paper presents CORIA, a software framework for an easy analysis of connectivity risks based on large network graphs. It provides researchers, risk analysts, network managers and security consultants with a tool to assess an organization's connectivity and paths options through the Internet backbone, including a user-friendly and insightful visual representation of results. CORIA is flexibly extensible in terms of novel data sets, graph metrics, and risk scores that enable further use cases. The performance of CORIA is evaluated by several experiments on the Internet graph and further randomly generated networks. KW - risk analysis KW - connectivity KW - graph analysis KW - complex networks KW - Internet Y1 - 2017 SN - 978-1-4673-8999-0 SN - 978-1-4673-9000-2 U6 - https://doi.org/10.1109/ICC.2017.7996828 SN - 1550-3607 PB - IEEE CY - Piscataway ER - TY - GEN A1 - Grossi, Giuseppe A1 - Reichard, Christoph A1 - Thomasson, Anna A1 - Vakkuri, Jarmo T1 - Editorial T2 - Public money & management : integrating theory and practice in public management Y1 - 2017 U6 - https://doi.org/10.1080/09540962.2017.1344007 SN - 0954-0962 SN - 1467-9302 VL - 37 SP - 379 EP - 386 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Hass, Roland A1 - Sandmann, Michael A1 - Reich, Oliver T1 - Photonic sensing in highly concentrated biotechnical processes by photon density wave spectroscopy T2 - Proceedings SPIE 10323, 25th International Conference on Optical Fiber Sensors N2 - Photon Density Wave (PDW) spectroscopy is introduced as a new approach for photonic sensing in highly concentrated biotechnical processes. It independently quantifies the absorption and reduced scattering coefficient calibration-free and as a function of time, thus describing the optical properties in the vis/NIR range of the biomaterial during their processing. As examples of industrial relevance, enzymatic milk coagulation, beer mashing, and algae cultivation in photo bioreactors are discussed. KW - Photon Density Wave Spectroscopy KW - multiple light scattering KW - fermentation KW - algae cultivation KW - process analytical technology KW - fiber spectroscopy Y1 - 2017 SN - 978-1-5090-4850-2 U6 - https://doi.org/10.1117/12.2263617 SN - 0277-786X SN - 1996-756X VL - 10323 PB - IEEE CY - New York ER - TY - JOUR A1 - Schmidt, Marco F. T1 - miRNA Targeting Drugs BT - the next blockbusters? JF - Drug Target miRNA: Methods and Protocols N2 - Only 20 years after the discovery of small non-coding, single-stranded ribonucleic acids, so-called microRNAs (miRNAs), as post-transcriptional gene regulators, the first miRNA-targeting drug Miravirsen for the treatment of hepatitis C has been successfully tested in clinical Phase II trials. Addressing miRNAs as drug targets may enable the cure, or at least the treatment of diseases, which presently seems impossible. However, due to miRNAs’ chemical structure, generation of potential drug molecules with necessary pharmacokinetic properties is still challenging and requires a re-thinking of the drug discovery process. Therefore, this chapter highlights the potential of miRNAs as drug targets, discusses the challenges, and tries to give a complete overview of recent strategies in miRNA drug discovery. KW - miRNA KW - Drug discovery KW - microRNA-induced silencing complex KW - Antisense agents KW - Small-molecule miRNA modulators KW - Argonaute 2 protein Y1 - 2016 SN - 978-1-4939-6563-2 SN - 978-1-4939-6561-8 U6 - https://doi.org/10.1007/978-1-4939-6563-2_1 SN - 1064-3745 SN - 1940-6029 VL - 1517 SP - 3 EP - 22 PB - Springer CY - New York ER - TY - JOUR A1 - Atilaw, Yoseph A1 - Duffy, Sandra A1 - Heydenreich, Matthias A1 - Muiva-Mutisya, Lois A1 - Avery, Vicky M. A1 - Erdelyi, Mate A1 - Yenesew, Abiy T1 - Three Chalconoids and a Pterocarpene from the Roots of Tephrosia aequilata JF - Molecules N2 - In our search for new antiplasmodial agents, the CH2Cl2/CH3OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2,6-dimethoxy-3,4-(2,2-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2,6-dimethoxy-3,4-(2,2-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4-ethoxy-3-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum. KW - Tephrosia aequilata KW - chalcone KW - retrochalcone KW - aequichalcone A KW - aequichalcone B KW - aequichalcone C KW - pterocarpene KW - antiplasmodial Y1 - 2017 U6 - https://doi.org/10.3390/molecules22020318 SN - 1420-3049 VL - 22 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Nishino, Takeshi A1 - Okamoto, Ken A1 - Leimkühler, Silke T1 - Enzymes of the Xanthine Oxidase Family JF - Molybdenum and tungsten enzymes : biochemistry N2 - Enzymes from the xanthine oxidase (XO) family of molybdenum enzymes are generally, with some exceptions, molybdenum iron–sulfur flavin hydroxylases. Mammalian xanthine oxidoreductase and aldehyde oxidase were among the first enzymes to be studied in detail more than 100 years ago and, surprisingly, they continue to be thoroughly studied in molecular detail with many open and unresolved questions remaining. Enzymes of the XO family are characterized by a molybdenum cofactor (Moco) active site with a MoVIOS(OH) ligand sphere where substrate hydroxylation of either aromatic or aliphatic carbon centers is catalyzed. During the reaction, electrons are transferred to the oxidizing substrate, most commonly O2 or NAD+, which react at the FAD site. Y1 - 2016 SN - 978-1-78262-391-5 SN - 978-1-78262-089-1 SN - 978-1-78262-881-1 U6 - https://doi.org/10.1039/9781782623915-00192 VL - 5 SP - 192 EP - 239 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Leimkühler, Silke A1 - Lemaire, Olivier N. A1 - Iobbi-Nivol, Chantal T1 - Bacterial Molybdoenzymes BT - Chaperones, Assembly and Insertion JF - Molybdenum and tungsten enzymes : biochemistry N2 - The biogenesis of molybdoenzymes is a cytoplasmic event requiring both the folded apoenzymes and the matured molybdenum cofactor. The structure and the complexity of the molybdenum cofactor varies in each molybdoenzyme family and consequently different accessory proteins are required for the maturation of the respective enzymes. Thus, for enzymes of both the DMSO reductase and xanthine oxidase families, specific chaperones exist which are dedicated to increase the stability and the folding of specific members of each family. In this review, we describe the role of these chaperones for molybdoenzyme maturation. We present a model which describes step by step the mechanism of the maturation of representative molybdoenzymes from each family. Y1 - 2016 SN - 978-1-78262-391-5 SN - 978-1-78262-089-1 U6 - https://doi.org/10.1039/9781782623915-00117 VL - 5 SP - 117 EP - 142 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Leimkühler, Silke A1 - Mendel, Ralf-Rainer T1 - Molybdenum Cofactor Biosynthesis JF - Molybdenum and tungsten enzymes: biochemistry N2 - The biosynthesis of the molybdenum cofactor (Moco) is highly conserved among all kingdoms of life. In all molybdoenzymes with the exception of nitrogenase, the molybdenum atom is coordinated to a dithiolene group present in the pterin-based 6-alkyl side chain of molybdopterin (MPT). In general, the biosynthesis of Moco can be divided into three steps in eukaryotes, and four steps in bacteria and archaea: (i) the starting point is the formation of the cyclic pyranopterin monophosphate (cPMP) from 5′GTP, (ii) in the second step the two sulfur molecules are inserted into cPMP leading to the formation of MPT, (iii) in the third step the molybdenum atom is inserted into molybdopterin to form Moco and (iv) additional modification of Moco occurs in bacteria and archaea with the attachment of a nucleotide (CMP or GMP) to the phosphate group of MPT, forming the dinucleotide variants of Moco. This review will focus on the biosynthesis of Moco in bacteria, humans and plants. Y1 - 2016 SN - 978-1-78262-391-5 SN - 978-1-78262-089-1 SN - 978-1-78262-881-1 U6 - https://doi.org/10.1039/9781782623915 VL - 5 SP - 100 EP - 116 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Kühne, Franziska A1 - Maas, Jana A1 - Wiesenthal, Sophia A1 - Weck, Florian T1 - Supervision in der Verhaltenstherapie T1 - Supervision in behavioral therapy BT - ein Scoping Review zur Identifikation von Forschungszielen BT - a scoping review for identification of research objectives JF - Zeitschrift für klinische Psychologie und Psychotherapie : Forschung und Praxis N2 - Theoretischer Hintergrund:Supervision spielt eine zentrale Rolle zum Wissens- und Kompetenzerwerb sowie in der Qualitätssicherung. Fragestellung:Ziel war es, den aktuellen Forschungsstand zur Supervision im Rahmen der kognitiven Verhaltenstherapie abzubilden, um daraus Schlussfolgerungen für die zukünftige Forschung abzuleiten. Methode:Zur Evidenzsynthese wurde ein Scoping Review durchgeführt, das die Darstellung zentraler Konzepte, aktueller Evidenz und möglicher Forschungsbedarfe ermöglichte. Neben einer systematischen Literaturrecherche wurden Vorwärts- und Rückwärtssuchstrategien eingesetzt. Ergebnisse:Eingeschlossen wurden zwölf Publikationen basierend auf zehn empirischen Studien. Alle Studien beschrieben Ausbildungssettings, aber nur wenige untersuchten übende Interventionen (z. B. Rollenspiele). Häufig wurden Effekte subjektiv erfasst, die methodische Qualität der Begleitstudien variierte. Schlussfolgerungen:Notwendig sind weitere methodisch hochwertige Studien, experimentell orientiert oder in der klinischen Praxis, die die Supervisionsforschung bereichern können. N2 - Background:Supervision plays a central role for the acquisition of therapeutic knowledge and competence and for quality control. Objective:The study aimed at mapping the current evidence regarding cognitive–behavioral supervision, and drawing conclusions for future research. Method:For evidence synthesis, we conducted a scoping review to outline key concepts, the current evidence, and potential gaps in research. In addition to a systematic literature search, forward and backward search strategies were implemented. Results:We included 12 publications on 10 empirical studies. All studies referred to education and training, but only a few examined exercises (e. g., role plays). Mostly, outcomes were evaluated subjectively, and study quality varied. Conclusion:Further methodologically sound studies, experimentally oriented or in clinical care, may support research. KW - clinical supervision KW - review KW - scoping study KW - cognitive behavioral therapy KW - psychotherapy KW - klinische Supervision KW - Übersichtsarbeit KW - kognitive Verhaltenstheraphie KW - Psychoterapie Y1 - 2017 U6 - https://doi.org/10.1026/1616-3443/a000414 SN - 1616-3443 SN - 2190-6297 VL - 46 IS - 2 SP - 73 EP - 82 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Sander, Martha Maria A1 - Eccard, Jana A1 - Heim, Wieland T1 - Flight range estimation of migrant yellow-browed warblers phylloscopus inornatus on the East Asian flyway JF - Bird study : the journal of the British Trust for Ornithology N2 - Fat loads were quantified for 2125 Yellow-browed Warblers Phylloscopus inornatus trapped at a stop-over site in Far East Russia during autumn migration. Flight ranges of 660-820km were estimated for the fattest individuals, suggesting that they would need to stop for refuelling at least six times to reach their wintering areas in South East Asia. Y1 - 2017 U6 - https://doi.org/10.1080/00063657.2017.1409696 SN - 0006-3657 SN - 1944-6705 VL - 64 SP - 569 EP - 572 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Apelojg, Benjamin ED - Apelojg, Benjamin ED - Banse, Gerhard T1 - Innovationen als Element einer zukunftsweisenden ökonomischen und technischen Bildung JF - Technische Bildung und berufliche Orientierung im Wandel - Rückblicke, Einblicke, Ausblicke N2 - Innovationen sind wie ein Motor, der unser ökonomisches, soziales und ge-sellschaftliches Leben antreibt und laufend verändert. Ob in der Medizin-technik, Luft- und Raumfahrt, Energiegewinnung, im Netz oder in der Schule: In allen Bereichen sorgen Innovationen für die stetige Weiterent-wicklung unser Gesellschaft. Bernd Meier hat die Bedeutung von Innova-tionen und innovativem Denken für die technische Bildung und Schule früh erkannt. Mit einer kurzen Rückschau auf sein Wirken hinsichtlich der Be-deutung von Innovationen für die technische und ökonomische Bildung soll ein wichtiger Bereich seiner Arbeit gewürdigt werden. Zu Beginn wird der Innovationsbegriff allgemein umrissen und dann mit Blick auf Schule präzi-siert. Danach wird dargestellt, welchen Stellenwert die Thematik Innovation und Technologie nicht nur in den Publikationen von Bernd Meier, sondern auch in seinen Lehrkonzeptionen eingenommen hat. Im Anschluss daran wird diskutiert, warum es gerade im Bildungsbereich so schwer ist, innova-tiv zu sein oder dauerhaft Innovationen durchzusetzen.1 Der Beitrag endet mit einem Ausblick, inwiefern Innovationen auch in Zukunft für Schule und das Fach Wirtschaft-Arbeit-Technik (kurz: WAT) eine wichtige Thematik darstellen sollten. Y1 - 2017 SN - 978-3-86464-156-5 VL - 133/134 SP - 95 EP - 107 PB - Trafo-Verlag CY - Berlin ER - TY - JOUR A1 - Apelojg, Benjamin A1 - Bieniok, Majken ED - Fleischer, Lutz ED - Meier, Bernd T1 - Eine Kurzvorstellung der Felix-App und deren Einsatz im PSI-Projekt der Qualitätsoffensive Lehrerbildung JF - Technik und Technologie : Techne cum episteme et commune bonum. Ehrenkolloquium anlässlich des 70. Geburtstages von Gerhard Banse KW - Felix-App KW - Qualitätsoffensive Lehrerbildung KW - Evaluation von Unterricht Y1 - 2017 SN - 978-3-86464-154-1 VL - 131 SP - 223 EP - 234 PB - Trafo-Verlag CY - Berlin ER - TY - JOUR A1 - Arslan, Seçkin A1 - Gür, Eren A1 - Felser, Claudia T1 - Predicting the sources of impaired wh-question comprehension in non-fluent aphasia BT - a cross-linguistic machine learning study on Turkish and German JF - Cognitive neuropsychology N2 - This study investigates the comprehension of wh-questions in individuals with aphasia (IWA) speaking Turkish, a non-wh-movement language, and German, a wh-movement language. We examined six German-speaking and 11 Turkish-speaking IWA using picture-pointing tasks. Findings from our experiments show that the Turkish IWA responded more accurately to both object who and object which questions than to subject questions, while the German IWA performed better for subject which questions than in all other conditions. Using random forest models, a machine learning technique used in tree-structured classification, on the individual data revealed that both the Turkish and German IWA’s response accuracy is largely predicted by the presence of overt and unambiguous case marking. We discuss our results with regard to different theoretical approaches to the comprehension of wh-questions in aphasia. KW - Non-fluent aphasia KW - random forest algorithm KW - sentence comprehension KW - wh-in-situ KW - wh-questions KW - wh-movement Y1 - 2017 U6 - https://doi.org/10.1080/02643294.2017.1394284 SN - 0264-3294 SN - 1464-0627 VL - 34 SP - 312 EP - 331 PB - Taylor & Francis CY - Abingdon ER - TY - BOOK ED - Esguerra, Alejandro ED - Helmerich, Nicole ED - Risse, Thomas T1 - Sustainability Politics and Limited Statehood BT - Contesting the New Modes of Governance Y1 - 2017 SN - 978-3-319-39870-9 SN - 978-3-319-39871-6 U6 - https://doi.org/10.1007/978-3-319-39871-6 PB - Springer CY - Cham ER - TY - JOUR A1 - Reifegerste, Jana A1 - Hauer, Franziska A1 - Felser, Claudia T1 - Agreement processing and attraction errors in aging BT - evidence from subject-verb agreement in German JF - Aging, neuropsychology, and cognition : a journal on normal and dysfunctional development N2 - Effects of aging on lexical processing are well attested, but the picture is less clear for grammatical processing. Where age differences emerge, these are usually ascribed to working-memory (WM) decline. Previous studies on the influence of WM on agreement computation have yielded inconclusive results, and work on aging and subject-verb agreement processing is lacking. In two experiments (Experiment 1: timed grammaticality judgment, Experiment 2: self-paced reading + WM test), we investigated older (OA) and younger (YA) adults’ susceptibility to agreement attraction errors. We found longer reading latencies and judgment reaction times (RTs) for OAs. Further, OAs, particularly those with low WM scores, were more accepting of sentences with attraction errors than YAs. OAs showed longer reading latencies for ungrammatical sentences, again modulated by WM, than YAs. Our results indicate that OAs have greater difficulty blocking intervening nouns from interfering with the computation of agreement dependencies. WM can modulate this effect. KW - Subject-verb agreement KW - attraction errors KW - aging KW - grammaticality judgment KW - self-paced reading Y1 - 2016 U6 - https://doi.org/10.1080/13825585.2016.1251550 SN - 1382-5585 SN - 1744-4128 VL - 24 IS - 6 SP - 672 EP - 702 PB - Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Muwonge, Charles Magoba A1 - Schiefele, Ulrich A1 - Ssenyonga, Joseph A1 - Kibedi, Henry T1 - Self-regulated learning among teacher education students BT - Motivational beliefs influence on the use of metacognition JF - Journal of psychology in Africa N2 - In the present study, we examined the relationships between motivational beliefs (self-efficacy, task value, and control of learning beliefs) and use of metacognitive learning strategies among teacher education students in Uganda. The sample comprised of 649 students selected from seven universities. Data were collected using several scales from the modified Motivated Strategies for Learning Questionnaire, and analysed using Structural Equation Modelling. Task value and self-efficacy independently and significantly predicted students’ reported use of metacognition. Students’ self-reported self-efficacy and task value explained 38% of the variance in their use of metacognition. The evidence suggests interventions aimed at improving teacher education students’ metacognitive skills to focus on enhancing their efficacy and value beliefs. KW - metacognition KW - motivational beliefs KW - motivated strategies for learning questionnaire KW - teacher education students Y1 - 2017 U6 - https://doi.org/10.1080/14330237.2017.1399973 SN - 1433-0237 SN - 1815-5626 VL - 27 IS - 6 SP - 515 EP - 521 PB - Routledge CY - Abingdon ER - TY - JOUR A1 - Pospisil, Christina A1 - Czernitzki, Anna-Franziska A1 - Scheffler, Christiane T1 - No association between nutrition and body height in German kindergarten children BT - a pilot study JF - Journal of biological and clinical anthropology : Anthropologischer Anzeiger; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Anthropologists all over the world are discussing influences on individual height including quantity and quality of nutrition. To examine whether a relationship between nutritional components and height can be found this pilot study has been developed. The research samples consisted of 44 children (age 3–6 years) attending two different kindergartens in Germany. Height measurements were taken for each child. Furthermore the parents had to fill out a 24-hour questionnaire to document their children’s eating habits during the weekend. In order to standardize the measured height values z-scores were calculated with reference to the average height of the overall cohort. The results of correlation analysis indicate that height is not significantly related to any of the main nutritional components as protein (r = –0.148), carbohydrates (r = 0.126), fat (r = 0.107), fibre (r = –0.289), vitamin (r = 0.050), calcium (r = 0.110), potassium (r = 0.189) and overall calorie intake (r = 0.302). In conclusion, it can be stated that the quality of nutrition may not have a strong influence on individual height. However, due to the small sample size further research should be provided with a larger cohort of children to verify the present results. KW - nutritional components KW - individual body height KW - children KW - Germany Y1 - 2017 U6 - https://doi.org/10.1127/anthranz/2017/0704 SN - 0003-5548 SN - 2363-7099 VL - 74 IS - 3 SP - 199 EP - 202 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Dorani, Maryam A1 - Arvin, Mohsen A1 - Oberhänsli, Roland A1 - Dargahi, Sara T1 - P-T evolution of metapelites from the Bajgan complex in the Makran accretionary prism, south eastern Iran JF - Chemie der Erde : interdisciplinary journal for chemical problems of the geo-sciences and geo-ecology = Geochemistry N2 - The Bajgan Complex, one of the basement constituents of the arc massif in Iranian Makran forms a rugged, deeply incised terrain. The complex consists of pelitic schists with minor psammitic and basic schists, calc silicate rocks, amphibolites, marbles, metavolcanosediments, mafic and felsic intrusives as well as ultramafic rocks. Metapelitic rocks show an amphibolite facies regional metamorphism and contain garnet, biotite, white mica, quartz, albite ± rutile ± apatite. Thermobarometry of garnet schist yields pressure of more than 9 kbar and temperatures between 560 and 675 °C. The geothermal gradient obtained for the peak of regional metamorphism is 19 °C/km, corresponding to a depth of ca. 31 km. Replacement of garnet by chlorite and epidote suggest greenschist facies metamorphism due to a decrease in temperature and pressure through exhumation and retrograde metamorphism (370–450 °C and 3–6 kbar). The metapelitic rocks followed a ‘clockwise’ P–T path during metamorphism, consistent with thermal decline following tectonic thickening. The formation of medium-pressure metamorphic rocks is related to presence of active subduction of the Neotethys Oceanic lithosphere beneath Eurasia in the Makran. KW - Bajgan Complex KW - Makran KW - Metapelitic rock KW - Garnet schist KW - Thermobarometry KW - Clockwise P-T path Y1 - 2017 U6 - https://doi.org/10.1016/j.chemer.2017.07.004 SN - 0009-2819 SN - 1611-5864 VL - 77 IS - 3 SP - 459 EP - 475 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Martykanova, Darina T1 - A Gateway to the World BT - Jewish and Armenian Engineers of Ottoman Background at the Ecole centrale des arts et manufactures (1853-1923) JF - Diasporas : circulations, migrations, histoire N2 - In the second half of the 19th century, the French École centrale des arts et manufactures became one of the engineering schools that enjoyed a worldwide reputation. There were many foreigners among its students. This article focuses on the graduates born in the Ottoman Empire, particularly on Jews and Armenians. It analyses their backgrounds, their common features and their professional careers, tracing their links with other centraliens. The patterns in the Ottoman centraliens’ professional trajectories help us picture a world full of opportunities where highly qualified men could cross borders and build careers with ease, but where, at the same time, origins, allegiances, contacts and credentials mattered greatly. N2 - Dans la seconde moitié du xixe siècle, l’École centrale des arts et manufactures française devint une école d’ingénieurs jouissant d’une réputation internationale ; les étudiants étrangers y furent nombreux. Cet article porte sur les diplômés nés dans l’Empire ottoman, en particuliers les étudiants juifs et arméniens ; il s’attache à leur parcours, à leurs caractéristiques et à leurs carrières professionnelles et restitue leurs liens avec les autres centraliens. L’étude de leurs trajectoires professionnelles permet d’appréhender un monde riche en opportunités, où des hommes hautement qualifiés pouvaient aisément traverser les frontières et construire une carrière, mais où, dans le même temps, les origines, les réseaux d’allégeance, les relations et les diplômes jouent un rôle de premier plan. KW - Engineers KW - Jews KW - Armenians KW - Ottomans KW - Ecole centrale des arts et manufactures KW - networks KW - Ottoman Empire KW - France KW - transnational Y1 - 2017 U6 - https://doi.org/10.4000/diasporas.718 SN - 1637-5823 SN - 2431-1472 VL - 29 SP - 33 EP - 51 PB - Presses Universitaires du Midi CY - Toulouse ER - TY - JFULL T1 - Editorial Board T2 - Public management review Y1 - 2017 U6 - https://doi.org/10.1080/14719037.2017.1367563 SN - 1471-9037 SN - 1471-9045 VL - 19 IS - 10 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Herbst - Voeth, Uta A1 - Dotan, Hilla A1 - Stöhr, Sina T1 - Negotiating with work friends BT - examining gender differences in team negotiations JF - The journal of business & industrial marketing N2 - Purpose - This study aims to investigate whether a team of females negotiates differently than a team of males, and whether (workplace) friendship moderates the relationship between single-gender team composition and negotiation outcomes. Design/methodology/approach - The authors used two laboratory studies and paired 216 MBA students into single-gender teams of friends and non-friends, and then engaged them in several dyadic multi-issue negotiations. Findings - The results show that on average, male teams of non-friends reached significantly better outcomes than female teams of non-friends. However, and interestingly, female teams of friends perform equally to male teams of friends. Research limitations/implications - The authors contribute both to the negotiations and the workplace friendship literature because very little research has examined negotiation among friends at work and in particular team negotiations. In addition, the authors also contribute to the literature on gender differences in negotiations because existing research has rarely examined the differences between all-male and all-female teams and especially the relationship between same-sex teams and their effects on negotiation outcomes. Practical implications - This research has clear implications to managers with regard to team composition. Specifically, a winning all-female team should not be changed! Originality/value - This is the first study to examine the relationship between workplace friendship, gender and negotiation outcomes. KW - Multi-issue negotiation KW - Negotiation performance KW - Gender effects KW - Intra-team friendship KW - Team negotiations KW - Workplace friendships Y1 - 2017 U6 - https://doi.org/10.1108/JBIM-12-2015-0250 SN - 0885-8624 SN - 2052-1189 VL - 32 SP - 558 EP - 566 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Preuss, Melanie A1 - van der Wijst, Per T1 - A phase-specific analysis of negotiation styles JF - The journal of business & industrial marketing N2 - Purpose - The purpose of this study is to analyze whether negotiators stick to one single negotiation style or whether their styles vary during the negotiation process. The paper seeks to identify different combinations of phase-specific negotiation styles and investigates the relationship between these combinations and negotiation performance and satisfaction. Design/methodology/approach - The study is based on a large online negotiation simulation that allows a phase-specific analysis of negotiation styles via an elaborate coding scheme. Findings - The findings reveal that negotiators generally do not limit themselves to a single negotiation style. Instead, they vary their style in the course of different negotiation phases. The authors distinguish between five distinct phase-specific negotiation style patterns that differ with regard to their impact on negotiation performance but not negotiation satisfaction. Practical implications - Negotiation practitioners get to know different phase-specific negotiation style patterns and get insights into which pattern is the most promising for negotiation performance. As a result, they can acquire this phase-specific negotiation style pattern to enhance their performance. Originality/value - The paper contributes to existing negotiation style literature, because it is the first to analyze negotiation styles from a phase-specific point of view. KW - Business-to-business marketing KW - Negotiation performance KW - Negotiation phases KW - Negotiation satisfaction KW - Negotiation styles Y1 - 2017 U6 - https://doi.org/10.1108/JBIM-01-2016-0010 SN - 0885-8624 SN - 2052-1189 VL - 32 IS - 4 SP - 505 EP - 518 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Schmidt, Marco F. A1 - Korb, Oliver A1 - Abell, Chris T1 - Antagonists of the miRNA-Argonaute 2 Protein Complex BT - Anti-miR-AGOs JF - Drug Target miRNA: Methods and Protocols N2 - microRNAs (miRNAs) have been identified as high-value drug targets. A widely applied strategy in miRNA inhibition is the use of antisense agents. However, it has been shown that oligonucleotides are poorly cell permeable because of their complex chemical structure and due to their negatively charged backbone. Consequently, the general application of oligonucleotides in therapy is limited. Since miRNAs’ functions are executed exclusively by the Argonaute 2 protein, we therefore describe a protocol for the design of a novel miRNA inhibitor class: antagonists of the miRNA-Argonaute 2 protein complex, so-called anti-miR-AGOs, that not only block the crucial binding site of the target miRNA but also bind to the protein’s active site. Due to their lower molecular weight and, thus, more drug-like chemical structure, the novel inhibitor class may show better pharmacokinetic properties than reported oligonucleotide inhibitors, enabling them for potential therapeutic use. KW - Drug design KW - microRNA KW - miRNA-Argonaute 2 protein complex KW - miRNA inhibitors KW - miRNA seed region Y1 - 2016 SN - 978-1-4939-6563-2 SN - 978-1-4939-6561-8 SN - 978-1-4939-8236-3 U6 - https://doi.org/10.1007/978-1-4939-6563-2_17 SN - 1064-3745 SN - 1940-6029 VL - 1517 SP - 239 EP - 249 PB - Springer CY - New York ER - TY - JOUR A1 - Zou, Jie A1 - Wang, Weiwei A1 - Neffe, Axel T. A1 - Xu, Xun A1 - Li, Zhengdong A1 - Deng, Zijun A1 - Sun, Xianlei A1 - Ma, Nan A1 - Lendlein, Andreas T1 - Adipogenic differentiation of human adipose derived mesenchymal stem cells in 3D architectured gelatin based hydrogels (ArcGel) JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Polymeric matrices mimicking multiple functions of the ECM are expected to enable a material induced regeneration of tissues. Here, we investigated the adipogenic differentiation of human adipose derived mesenchymal stem cells (hADSCs) in a 3D architectured gelatin based hydrogel (ArcGel) prepared from gelatin and L-lysine diisocyanate ethyl ester (LDI) in an one-step process, in which the formation of an open porous morphology and the chemical network formation were integrated. The ArcGel was designed to support adipose tissue regeneration with its 3D porous structure, high cell biocompatibility, and mechanical properties compatible with human subcutaneous adipose tissue. The ArcGel could support initial cell adhesion and survival of hADSCs. Under static culture condition, the cells could migrate into the inner part of the scaffold with a depth of 840 +/- 120 mu m after 4 days, and distributed in the whole scaffold (2mm in thickness) within 14 days. The cells proliferated in the scaffold and the fold increase of cell number after 7 days of culture was 2.55 +/- 0.08. The apoptotic rate of hADSCs in the scaffold was similar to that of cells maintained on tissue culture plates. When cultured in adipogenic induction medium, the hADSCs in the scaffold differentiated into adipocytes with a high efficiency (93 +/- 1%). Conclusively, this gelatin based 3D scaffold presented high cell compatibility for hADSC cultivation and differentiation, which could serve as a potential implant material in clinical applications for adipose tissue reparation and regeneration. KW - Mesenchymal stem cells KW - gelatin based scaffold KW - adipose tissue regeneration KW - adipogenic differentiation Y1 - 2017 U6 - https://doi.org/10.3233/CH-179210 SN - 1386-0291 SN - 1875-8622 VL - 67 IS - 3-4 SP - 297 EP - 307 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Vasiliev, Sergey B. A1 - Tarchanov, Nikolaj Nikolaevič T1 - Construction of series of perfect lattices by layer superposition JF - Journal of Siberian Federal University : Mathematics & physics JF - Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University : Serija Matematika i fizika = Mathematics & physics N2 - We construct a new series of perfect lattices in n dimensions by the layer superposition method of Delaunay-Barnes. KW - lattice packing and covering KW - polyhedra and polytopes KW - regular figures KW - division of spaces Y1 - 2017 U6 - https://doi.org/10.17516/1997-1397-2017-10-3-353-361 SN - 1997-1397 SN - 2313-6022 VL - 10 IS - 3 SP - 353 EP - 361 PB - Sibirskij Federalʹnyj Universitet CY - Krasnojarsk ER - TY - JOUR A1 - Boxell, Oliver A1 - Felser, Claudia A1 - Cunnings, Ian T1 - Antecedent contained deletions in native and non-native sentence processing JF - Linguistic approaches to bilingualism N2 - We report the results from an eye-movement monitoring study investigating native (L1) and non-native (L2) speakers’ real-time processing of antecedent-contained deletion (ACD), a type of verb phrase ellipsis in which the ellipsis gap forms part of its own antecedent. The resulting interpretation problem is traditionally thought to be solved by quantifier raising, a covert scope-shifting operation that serves to remove the gap from within its antecedent. Our L2 group comprised advanced, native German-speaking L2 learners of English. The analysis of the eye-movement data showed that both L1 and L2 English speakers tried to recover the missing verb phrase after encountering the gap. Only the native speakers showed evidence of ellipsis resolution being affected by quantification, however. No effects of quantification following gap detection were found in the L2 group, by contrast, indicating that recovery of the elided material was accomplished independently from the object’s quantificational status in this group. KW - L2 processing KW - eye-movement monitoring KW - antecedent contained deletion Y1 - 2016 U6 - https://doi.org/10.1075/lab.15006.box SN - 1879-9264 SN - 1879-9272 VL - 7 IS - 5 SP - 554 EP - 582 PB - John Benjamins Publishing Co. CY - Amsterdam ER - TY - JOUR A1 - Mah, Dana-Kristin A1 - Ifenthaler, Dirk T1 - Academic staff perspectives on first-year students’ academic competencies JF - Journal of applied research in higher education : JARHE N2 - Purpose: The purpose of this paper is to examine the expectations, perceptions and role understanding of academic staff using a model of academic competencies (i.e. time management, learning skills, technology proficiency, self-monitoring and research skills). Design/methodology/approach: Semi-structured interviews were conducted with ten members of academic staff at a German university. Participants’ responses to the open-ended questions were coded inductively, while responses concerning the proposed model of academic competencies were coded deductively using a priori categories. Findings: Participating academic staff expected first-year students to be most competent in time management and in learning skills; they perceived students’ technology proficiency to be rather high but their research skills as low. Interviews indicated a mismatch between academic staff expectations and perceptions. Practical implications: These findings may enable universities to provide support services for first-year students to help them to adjust to the demands of higher education. They may also serve as a platform to discuss how academic staff can support students to develop the required academic competencies, as well as a broader conversation about higher education pedagogy and competency assessment. Originality/value: Little research has investigated the perspectives of academic staff concerning the academic competencies they expect of first-year students. Understanding their perspectives is crucial for improving the quality of institutions; their input into the design of effective support services is essential, as is a constructive dialogue to identify strategies to enhance student retention. KW - Expectations KW - Support KW - First-year experience KW - Academic competencies KW - Academic staff perspectives Y1 - 2017 U6 - https://doi.org/10.1108/JARHE-03-2017-0023 SN - 2050-7003 SN - 1758-1184 VL - 9 IS - 4 SP - 630 EP - 640 PB - Emerald Group Publishing Limited CY - Bingley ER - TY - JOUR A1 - Arantzeta, Miren A1 - Bastiaanse, Roelien A1 - Burchert, Frank A1 - Wieling, Martijn Benjamin A1 - Martinez-Zabaleta, Maite A1 - Laka, Itziar T1 - Eye-tracking the effect of word order in sentence comprehension in aphasia BT - evidence from Basque, a free word order ergative language JF - Language, cognition and neuroscience N2 - Agrammatic speakers of languages with overt grammatical case show impaired use of the morphological cues to establish theta-role relations in sentences presented in non-canonical word orders. We analysed the effect of word order on the sentence comprehension of aphasic speakers of Basque, an ergative, free word order and head-final (SOV) language. Ergative languages such as Basque establish a one-to-one mapping of the thematic role and the case marker. We collected behavioural and gaze-fixation data while agrammatic speakers performed a picture-matching task with auditorily presented sentences with different word orders. We found that people with aphasia (PWA) had difficulties in assigning theta-roles in Theme-Agent order. This result is in line with processing accounts. Contrary to previous findings, our data do not suggest a systematic delay in the integration of morphological information in the PWA group, but strong reliance on the ergative case morphology and difficulties assigning thematic roles into the determiner phrases. KW - Aphasia KW - comprehension KW - Basque KW - sentence processing KW - eye-tracking Y1 - 2017 U6 - https://doi.org/10.1080/23273798.2017.1344715 SN - 2327-3798 SN - 2327-3801 VL - 32 IS - 10 SP - 1320 EP - 1343 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Lu, Yong-Ping A1 - Hasan, Ahmed A. A1 - Zeng, Shufei A1 - Hocher, Berthold T1 - Plasma ET-1 concentrations are elevated in pregnant women with hypertension - meta-analysis of clinical studies JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: The ET system might be involved in the pathogenesis of hypertensive disorders during pregnancy. The objective is to analyse the impact of ET-1 in hypertensive pregnant women by a strict meta-analysis of published human clinical studies. Methods: Based on the principle of Cochrane systematic reviews, Cohort studies in PubMed (Medline), Google Scholar and China Biological Medicine Database (CBM-disc) designed to identify the role of endothelin-1 (ET-1) in the pathophysiology of gestational hypertension and preeclampsia were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects model. Results: Sixteen published cohort studies including 1739 hypertensive cases and 409 controls were used in the meta-analysis. ET-1 plasma concentrations were higher in hypertensive pregnant women as compared to the controls (mean difference between groups: 19.02 [15.60～22.44], P < 0.00001,). These finding were driven by severity of hypertension and/or degree of proteinuria. Conclusion: Plasma ET-1 concentrations are elevated in hypertensive disorders during human pregnancy. In particular women with preeclampsia (hypertensive pregnant women with proteinuria) have substantially elevated plasma ET-1 concentration as compared to pregnant women with normal blood pressure. KW - Et-1 KW - Pregnancy KW - Hypertension KW - Meta-analysis Y1 - 2017 U6 - https://doi.org/10.1159/000482004 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 4 SP - 654 EP - 663 PB - Karger CY - Basel ER - TY - JOUR A1 - Dahlke, Sandro A1 - Maturilli, Marion T1 - Contribution of atmospheric advection to the amplified winter warming in the arctic north atlantic region JF - Advances in meteorology N2 - Arctic Amplification of climate warming is caused by various feedback processes in the atmosphere-ocean-ice system and yields the strongest temperature increase during winter in the Arctic North Atlantic region. In our study, we attempt to quantify the advective contribution to the observed atmospheric warming in the Svalbard area. Based on radiosonde measurements from Ny-Ålesund, a strong dependence of the tropospheric temperature on the synoptic flow direction is revealed. Using FLEXTRA backward trajectories, an increase of advection from the lower latitude Atlantic region towards Ny-Ålesund is found that is attributed to a change in atmospheric circulation patterns. We find that about one-quarter (0.45 K per decade) of the observed atmospheric winter near surface warming trend in the North Atlantic region of the Arctic (2 K per decade) is due to increased advection of warm and moist air from the lower latitude Atlantic region, affecting the entire troposphere. Y1 - 2017 U6 - https://doi.org/10.1155/2017/4928620 SN - 1687-9309 SN - 1687-9317 PB - Hindawi Publ. Corp. CY - New York ER - TY - GEN A1 - Loupos, Konstantinos A1 - Damigos, Yannis A1 - Amditis, Angelos A1 - Gerhard, Reimund A1 - Rychkov, Dmitry A1 - Wirges, Werner A1 - Schulze, Manuel A1 - Lenas, Sotiris-Angelos A1 - Chatziandreoglou, Christos A1 - Malliou, Christina A1 - Tsaoussidis, Vassilis A1 - Brady, Ken A1 - Frankenstein, Bernd T1 - Structural health monitoring system for bridges based on skin-like sensor T2 - IOP conference series : Materials science and engineering N2 - Structural health monitoring activities are of primal importance for managing transport infrastructure, however most SHM methodologies are based on point-based sensors that have limitations in terms of their spatial positioning requirements, cost of development and measurement range. This paper describes the progress on the SENSKIN EC project whose objective is to develop a dielectric-elastomer and micro-electronics-based sensor, formed from a large highly extensible capacitance sensing membrane supported by advanced microelectronic circuitry, for monitoring transport infrastructure bridges. Such a sensor could provide spatial measurements of strain in excess of 10%. The actual sensor along with the data acquisition module, the communication module and power electronics are all integrated into a compact unit, the SENSKIN device, which is energy-efficient, requires simple signal processing and it is easy to install over various surface types. In terms of communication, SENSKIN devices interact with each other to form the SENSKIN system; a fully distributed and autonomous wireless sensor network that is able to self-monitor. SENSKIN system utilizes Delay-/Disruption-Tolerant Networking technologies to ensure that the strain measurements will be received by the base station even under extreme conditions where normal communications are disrupted. This paper describes the architecture of the SENSKIN system and the development and testing of the first SENSKIN prototype sensor, the data acquisition system, and the communication system. Y1 - 2017 U6 - https://doi.org/10.1088/1757-899X/236/1/012100 SN - 1757-8981 VL - 236 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Gebser, Martin A1 - Maratea, Marco A1 - Ricca, Francesco T1 - The sixth answer set programming competition JF - Journal of artificial intelligence research : JAIR N2 - Answer Set Programming (ASP) is a well-known paradigm of declarative programming with roots in logic programming and non-monotonic reasoning. Similar to other closely related problemsolving technologies, such as SAT/SMT, QBF, Planning and Scheduling, advancements in ASP solving are assessed in competition events. In this paper, we report about the design and results of the Sixth ASP Competition, which was jointly organized by the University of Calabria (Italy), Aalto University (Finland), and the University of Genoa (Italy), in affiliation with the 13th International Conference on Logic Programming and Non-Monotonic Reasoning. This edition maintained some of the design decisions introduced in 2014, e.g., the conception of sub-tracks, the scoring scheme,and the adherence to a fixed modeling language in order to push the adoption of the ASP-Core-2 standard. On the other hand, it featured also some novelties, like a benchmark selection stage classifying instances according to their empirical hardness, and a “Marathon” track where the topperforming systems are given more time for solving hard benchmarks. Y1 - 2017 U6 - https://doi.org/10.1613/jair.5373 SN - 1076-9757 SN - 1943-5037 VL - 60 SP - 41 EP - 95 PB - AI Access Found. CY - Marina del Rey ER - TY - JOUR A1 - Li, Zhengdong A1 - Xu, Xun A1 - Wang, Weiwei A1 - Kratz, Karl A1 - Sun, Xianlei A1 - Zou, Jie A1 - Deng, Zijun A1 - Jung, Friedrich Wilhelm A1 - Gossen, Manfred A1 - Ma, Nan A1 - Lendlein, Andreas T1 - Modulation of the mesenchymal stem cell migration capacity via preconditioning with topographic microstructure JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Controlling mesenchymal stem cells (MSCs) behavior is necessary to fully exploit their therapeutic potential. Various approaches are employed to effectively influence the migration capacity of MSCs. Here, topographic microstructures with different microscale roughness were created on polystyrene (PS) culture vessel surfaces as a feasible physical preconditioning strategy to modulate MSC migration. By analyzing trajectories of cells migrating after reseeding, we demonstrated that the mobilization velocity of human adipose derived mesenchymal stem cells (hADSCs) could be promoted by and persisted after brief preconditioning with the appropriate microtopography. Moreover, the elevated activation levels of focal adhesion kinase (FAK) and mitogen-activated protein kinase (MAPK) in hADSCs were also observed during and after the preconditioning process. These findings underline the potential enhancement of in vivo therapeutic efficacy in regenerative medicine via transplantation of topographic microstructure preconditioned stem cells. KW - Mesenchymal stem cells KW - precondition KW - microstructure KW - migration KW - FAK-MAPK Y1 - 2017 U6 - https://doi.org/10.3233/CH-179208 SN - 1386-0291 SN - 1875-8622 VL - 67 SP - 267 EP - 278 PB - IOS Press CY - Amsterdam ER - TY - BOOK A1 - Apelojg, Benjamin A1 - Banse, Gerhard ED - Apelojg, Benjamin ED - Banse, Gerhard T1 - Technische Bildung und berufliche Orientierung im Wandel BT - Rückblicke, Einblicke, Ausblicke T3 - Sammelband N2 - Der Band versammelt 21 Beiträge, die unter dem Titel "Technische Bildung und berufliche Orientierung im Wandel" aus Anlass der Emeritierung von Prof. Dr. paed. habil Bernd Meier, Professur für Technologie und Berufliche Orientierung an der Wirtschafts- und Sozialwissenschaftlichen Fakultät der Universität Potsdam, auf einem Kolloquium 2017 gehalten wurden. KW - Technische Bildung KW - Wirtschaft, Arbeit, Technik Y1 - 2017 SN - 978-3864641565 VL - 133/134 PB - Trafo CY - Berlin ER - TY - JFULL ED - Carlà-Uhink, Filippo ED - Lindner, Martin T1 - Imagines BT - classical receptions in the visual and performing arts N2 - This series seeks to broaden the scholarly community’s understanding of the reception of classical antiquity in the visual and performing arts. A particular focus will be drawn on the 20th and 21st centuries and on media that have been traditionally neglected because considered “commercial” and/or “popular”, such as comics, advertising, digital media, design, fashion, and theme parks. It challenges traditional, and still very widespread, assumptions that distinguish “high” from “popular” culture, but also demonstrates the indisputable importance that classical antiquity enjoys in the modern and postmodern world, and all across the planet, carefully looking at forms of Classical Receptions outside the “traditional” regions object of such studies. Through a consistent shift from the traditional, academic approach, the series is the product of a continuous dialogue between scholars on the one side, and “producers” of classical reception – painters, sculptors, photographs, architects, designers, etc. –on the other, who write about their mechanisms of appropriation of the Ancient world . Each book highlights the popularity of antiquity today and reveals the forms and mechanisms of its reception. The series thus explains the choice of subjects and motives, the elaboration and re-mediatization processes taking place in the creative act, as well as the complexity of the “reception chains”, which make it today impossible, for instance, to visualize the ancient world without the filter of historical movies. Y1 - 2017 PB - Bloomsbury Academic CY - London ER - TY - JOUR A1 - Toy, Virginia Gail A1 - Sutherland, Rupert A1 - Townend, John A1 - Allen, Michael J. A1 - Becroft, Leeza A1 - Boles, Austin A1 - Boulton, Carolyn A1 - Carpenter, Brett A1 - Cooper, Alan A1 - Cox, Simon C. A1 - Daube, Christopher A1 - Faulkner, D. R. A1 - Halfpenny, Angela A1 - Kato, Naoki A1 - Keys, Stephen A1 - Kirilova, Martina A1 - Kometani, Yusuke A1 - Little, Timothy A1 - Mariani, Elisabetta A1 - Melosh, Benjamin A1 - Menzies, Catriona D. A1 - Morales, Luiz A1 - Morgan, Chance A1 - Mori, Hiroshi A1 - Niemeijer, Andre A1 - Norris, Richard A1 - Prior, David A1 - Sauer, Katrina A1 - Schleicher, Anja Maria A1 - Shigematsu, Norio A1 - Teagle, Damon A. H. A1 - Tobin, Harold A1 - Valdez, Robert A1 - Williams, Jack A1 - Yeo, Samantha A1 - Baratin, Laura-May A1 - Barth, Nicolas A1 - Benson, Adrian A1 - Boese, Carolin A1 - Célérier, Bernard A1 - Chamberlain, Calum J. A1 - Conze, Ronald A1 - Coussens, Jamie A1 - Craw, Lisa A1 - Doan, Mai-Linh A1 - Eccles, Jennifer A1 - Grieve, Jason A1 - Grochowski, Julia A1 - Gulley, Anton A1 - Howarth, Jamie A1 - Jacobs, Katrina A1 - Janku-Capova, Lucie A1 - Jeppson, Tamara A1 - Langridge, Robert A1 - Mallyon, Deirdre A1 - Marx, Ray A1 - Massiot, Cécile A1 - Mathewson, Loren A1 - Moore, Josephine A1 - Nishikawa, Osamu A1 - Pooley, Brent A1 - Pyne, Alex A1 - Savage, Martha K. A1 - Schmitt, Doug A1 - Taylor-Offord, Sam A1 - Upton, Phaedra A1 - Weaver, Konrad C. A1 - Wiersberg, Thomas A1 - Zimmer, Martin T1 - Bedrock geology of DFDP-2B, central Alpine Fault, New Zealand JF - New Zealand journal of geology and geophysics : an international journal of the geoscience of New Zealand, the Pacific Rim, and Antarctica ; NZJG N2 - During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled. KW - Alpine Fault KW - New Zealand KW - scientific drilling KW - mylonite KW - cataclasite Y1 - 2017 U6 - https://doi.org/10.1080/00288306.2017.1375533 SN - 0028-8306 SN - 1175-8791 VL - 60 IS - 4 SP - 497 EP - 518 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Fayyaz, Susann A1 - Japtok, Lukasz A1 - Schumacher, Fabian A1 - Wigger, Dominik A1 - Schulz, Tim Julius A1 - Haubold, Kathrin A1 - Gulbins, Erich A1 - Völler, Heinz A1 - Kleuser, Burkhard T1 - Lysophosphatidic acid inhibits insulin signaling in primary rat hepatocytes via the LPA(3) receptor subtype and is increased in obesity JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology N2 - Background/Aims: Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX). ATX converts lysophosphatidylcholine to lysophosphatidic acid (LPA) and acts as the main producer of extracellular LPA. This bioactive lipid regulates a broad range of physiological and pathological responses by activation of LPA receptors (LPA1-6). Methods: The activation of phosphatidylinositide 3-kinases (PI3K) signaling (Akt and GSK-3ß) was analyzed via western blotting in primary rat hepatocytes. Incorporation of glucose into glycogen was measured by using radio labeled glucose. Real-time PCR analysis and pharmacological modulation of LPA receptors were performed. Human plasma LPA levels of obese (BMI > 30, n = 18) and normal weight individuals (BMI 18.5-25, n = 14) were analyzed by liquid chromatography tandem-mass spectrometry (LC-MS/MS). Results: Pretreatment of primary hepatocytes with LPA resulted in an inhibition of insulin-mediated Gck expression, PI3K activation and glycogen synthesis. Pharmacological approaches revealed that the LPA3-receptor subtype is responsible for the inhibitory effect of LPA on insulin signaling. Moreover, human plasma LPA concentrations (16: 0 LPA) of obese participants (BMI > 30) are significantly elevated in comparison to normal weight individuals (BMI 18.5-25). Conclusion: LPA is able to interrupt insulin signaling in primary rat hepatocytes via the LPA3 receptor subtype. Moreover, the bioactive lipid LPA (16: 0) is increased in obesity. KW - Lysophosphatidic acid KW - Insulin signaling KW - Adipose tissue KW - Autotaxin KW - Hepatic insulin resistance KW - LPA(3) receptor subtype Y1 - 2017 U6 - https://doi.org/10.1159/000480470 SN - 1015-8987 SN - 1421-9778 VL - 43 SP - 445 EP - 456 PB - Karger CY - Basel ER - TY - GEN A1 - Nguyen, Vu Hoa A1 - Richert, S. A1 - Park, Hyunji A1 - Böker, Alexander A1 - Schnakenberg, Uwe T1 - Single interdigital transducer as surface acoustic wave impedance sensor T2 - Biosensors N2 - Surface acoustic wave (SAW) devices are well-known for gravimetric sensor applications. In biosensing applications, chemical-and biochemically evoked adsorption processes at surfaces are detected in liquid environments using delay-line or resonator sensor configurations, preferably in combination with appropriate microfluidic devices. In this paper, a novel SAW-based impedance sensor type is introduced which uses only one interdigital electrode transducer (IDT) simultaneously as SAW generator and sensor element. It is shown that the amplitude of the reflected S-11 signal directly depends on the input impedance of the SAW device. The input impedance is strongly influenced by mass adsorption which causes a characteristic and measurable impedance mismatch. KW - SAW impedance sensor KW - microfluidic KW - PHEMA Y1 - 2017 U6 - https://doi.org/10.1016/j.protcy.2017.04.032 SN - 2212-0173 VL - 27 SP - 70 EP - 71 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Hess, Markus A1 - Wirtz, Susanne A1 - Allroggen, Marc A1 - Scheithauer, Herbert T1 - Intervention und Therapie für Täter und Opfer von Schulbullying BT - ein systematisches Review BT - a systematic review JF - Praxis der Kinderpsychologie und Kinderpsychiatrie : Ergebnisse aus Psychotherapie, Beratung und Psychiatrie N2 - Bullying ist eine Form wiederholten, aggressiven Verhaltens mit ernstzunehmenden Auswirkungen, unter denen Täter und Opfer häufig lange nach Ende des Bullying-Geschehens leiden. Dennoch ist die Therapie von Bullying und den damit einhergehenden Folgen ein bisher in der Forschung vernachlässigtes Thema. Im Rahmen eines systematischen Literaturüberblicks wurde daher untersucht, welche Therapieformen zur Behandlung von Bullying und dessen Folgen bei Opfern und bei Tätern bereits angewendet wurden. Eine systematische Suche in nationalen und internationalen Datenbanken führte zu 31 relevanten Publikationen, in denen 34 therapeutische Interventionen aus über 14 Ländern beschrieben wurden. In zehn Therapiestudien mit kontrolliertem Design zeigte sich, dass Behandlungsangebote, die sich sowohl an die betroffenen Personen als auch an ihr soziales Umfeld richten, besonders effektiv in der Behandlung von Bullying-Folgen sind. Die restlichen 24 Behandlungsansätze wurden keiner kontrollierten Evaluation unterzogen. Insgesamt zwei Drittel aller therapeutischen Interventionen wenden sich an die Gruppe der Opfer. Hier wird im Unterschied zur Behandlung von Tätern verstärkt auf Gruppentherapien zurückgegriffen. Unter der Bandbreite an Ansätzen ist die kognitive Verhaltenstherapie am häufigsten vertreten. Festzustellen bleibt ein Forschungsmangel an evidenzbasierten, gezielten Interventionen zur Behandlung von Bullying und dessen Folgen bei Opfern und Tätern. Unseres Wissens stellt diese Arbeit den ersten systematischen Überblick zu therapeutischen Interventionen bei Bullying für Kinder und Jugendliche dar. T2 - Intervention and Therapy for Perpetrators and Victims of Bullying KW - therapy KW - intervention KW - perpetrator KW - victim KW - bullying KW - Therapie KW - Intervention KW - Täter KW - Opfer Y1 - 2017 U6 - https://doi.org/10.13109/prkk.2017.66.10.740 SN - 0032-7034 SN - 2196-8225 VL - 66 IS - 10 SP - 740 EP - 755 PB - Vandenhoeck & Ruprecht CY - Göttingen ER - TY - GEN A1 - Schmidt-Hattenberger, Cornelia A1 - Bergmann, Peter A1 - Labitzke, Tim A1 - Pommerencke, Julia A1 - Rippe, Dennis A1 - Wagner, Florian A1 - Wiese, Bernd T1 - Monitoring the complete life-cycle of a CO2 storage reservoir-Demonstration of applicability of geoelectrical imaging T2 - 13th International Conference on Greenhouse Gas Control Technologies (GHGT) N2 - In this paper, the applicability of deep downhole geoelectrical monitoring for detecting CO2 related signatures is evaluated after a nearly ten year period of CO2 storage at the Ketzin pilot site. Deep downhole electrode arrays have been studied as part of a multi-physical monitoring concept at four CO2 pilot test sites worldwide so far. For these sites, it was considered important to implement the geoelectrical method into the measurement program of tracking the CO2 plume. Analyzing the example of the Ketzin site, it can be seen that during all phases of the CO2 storage reservoir development the resistivity measurements and their corresponding tomographic interpretation contribute in a beneficial manner to the measurement, monitoring and verification (MMV) protocol. The most important impact of a permanent electrode array is its potential as tool for estimating reservoir saturations. KW - Geoeletrical imaging KW - permanent downhole electrode array KW - CO2 storage monitoring Y1 - 2017 U6 - https://doi.org/10.1016/j.egypro.2017.03.1526 SN - 1876-6102 VL - 114 SP - 3948 EP - 3955 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Al-Ani, Ayad T1 - CPS and the Worker BT - Reorientation and Requalification? JF - Industrial Internet of Things : Cybermanufacturing Systems N2 - The idea of interlinked, sensor-augmented, self-governing Cyber Physical System (CPS) production processes is gaining momentum. At the same time, the impact of this concept on the workforce remains surprisingly vague. This can be explained by the fact that man is not at the centre of these developments and—even more importantly—automation is geared towards eliminating human activity. Based on the first views in the 1980s, the label of the “process worker” assumed an almost exclusive focus on control and maintenance tasks for this new type of worker in the automated factory. Recent experiences show, however, that as long as robots are not self-learning, man will be the template for these machines and we can already notice the emerging parallelism of fully automated production lines and human workshops. The changing nature of the workforce will gain further momentum if one depicts new, open formats of production. Here, the worker will have to assume new roles in reconfiguring the production processes. Y1 - 2016 SN - 978-3-319-42559-7 SN - 978-3-319-42558-0 U6 - https://doi.org/10.1007/978-3-319-42559-7_23 SN - 2365-4139 SP - 563 EP - 574 PB - Springer CY - Cham ER - TY - JOUR A1 - Neuber, Corinna A1 - Schumacher, Fabian A1 - Gulbins, Erich A1 - Kleuser, Burkhard T1 - Mass Spectrometric Determination of Fatty Aldehydes Exemplified by Monitoring the Oxidative Degradation of (2E)-Hexadecenal in HepG2 Cell Lysates JF - Lipidomics N2 - Within the last few decades, liquid chromatography-mass spectrometry (LC-MS) has become a preferred method for manifold issues in analytical biosciences, given its high selectivity and sensitivity. However, the analysis of fatty aldehydes, which are important components of cell metabolism, remains challenging. Usually, chemical derivatization prior to MS detection is required to enhance ionization efficiency. In this regard, the coupling of fatty aldehydes to hydrazines like 2,4-dinitrophenylhydrazine (DNPH) is a common approach. Additionally, hydrazones readily react with fatty aldehydes to form stable derivatives, which can be easily separated using high-performance liquid chromatography (HPLC) and subsequently detected by MS. Here, we exemplarily present the quantification of the long-chain fatty aldehyde (2E)-hexadecenal, a break-down product of the bioactive lipid sphingosine 1-phosphate (S1P), after derivatization with 2-diphenylacetyl-1,3-indandione-1-hydrazone (DAIH) via isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight (ESI-QTOF) MS. Moreover, we show that the addition of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) as a coupling agent allows for simultaneous determination of fatty aldehydes and fatty acids as DAIH derivatives. Taking advantage of this, we describe in detail how to monitor the degradation of (2E)-hexadecenal and the concurrent formation of its oxidation product (2E)-hexadecenoic acid in lysates of human hepatoblastoma (HepG2) cells within this chapter. KW - (2E)-hexadecenal KW - (2E)-hexadecenoic acid KW - Sphingosine 1-phosphate KW - Derivatization KW - DAIH KW - EDC KW - Isotope-dilution KW - HPLC-ESI-QTOF Y1 - 2017 SN - 978-1-4939-6946-3 SN - 978-1-4939-6944-9 U6 - https://doi.org/10.1007/978-1-4939-6946-3_10 SN - 0893-2336 SN - 1940-6045 VL - 125 SP - 147 EP - 158 PB - Humana Press CY - Totowa ER - TY - JOUR A1 - Czernitzki, Anna-Franziska A1 - Pospisil, Christina A1 - Musalek, Martin A1 - Mumm, Rebekka A1 - Scheffler, Christiane T1 - Analysis of longitudinal data of height z-scores in kindergarten children BT - a pilot study JF - Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Changes in body height throughout extended historic periods are very complex and dynamic processes. Thispilot study aimed to investigate the pattern of longitudinal height z-scores changes in children before and after entering kindergarten. In summer 2016, we measured height and weight of 32 children from 4 groups of two kindergartens aged 3–6 years. All ages were centered according to the age of entry into the kindergarten. For each child we determined mean z-scores for height before and after entering the kindergarten, and assessed the variances for each kindergarten group. Twenty-two children targeted in height z-scores towards average height of their respective kindergarten group, 10 children did not. Due to the small numbers, the convergence in height variance however, remained insignificant (chi-squared independence test, p = 0.127). Additional studies with larger sample sizes are needed to confirm this pilot study. KW - Height z-score KW - kindergarten children KW - secular trend KW - strategic growth adjustment KW - social signal Y1 - 2017 U6 - https://doi.org/10.1127/anthranz/2017/0708 SN - 0003-5548 VL - 74 IS - 2 SP - 109 EP - 112 PB - Schweizerbart science publishers CY - Stuttgart ER - TY - JOUR A1 - Schwiebs, Anja A1 - Thomas, Dominique Jeanette A1 - Kleuser, Burkhard A1 - Pfeilschifter, Josef A1 - Radeke, Heinfried H. T1 - Nuclear translocation of SGPP-1 and decrease of SGPL-1 activity contribute to sphingolipid rheostat regulation of inflammatory dendritic cells JF - Mediators of inflammation N2 - A balanced sphingolipid rheostat is indispensable for dendritic cell function and survival and thus initiation of an immune response. Sphingolipid levels are dynamically maintained by the action of sphingolipid enzymes of which sphingosine kinases, S1P phosphatases (SGPP-1/2) and S1P lyase (SGPL-1), are pivotal in the balance of S1P and sphingosine levels. In this study, we present that SGPP-1 and SGPL-1 are regulated in inflammatory dendritic cells and contribute to S1P fate. TLR-dependent activation caused SGPL-1 protein downregulation with subsequent decrease of enzymatic activity by two-thirds. In parallel, confocal fluorescence microscopy revealed that endogenous SGPP-1 was expressed in nuclei of naive dendritic cells and was translocated into the cytoplasmatic compartment upon inflammatory stimulation resulting in dephosphorylation of S1P. Mass spectrometric determination showed that a part of the resulting sphingosine was released from the cell, increasing extracellular levels. Another route of diminishing intracellular S1P was possibly taken by its export via ATP-binding cassette transporter C1 which was upregulated in array analysis, while the S1P transporter, spinster homolog 2, was not relevant in dendritic cells. These investigations newly describe the sequential expression and localization of the endogenous S1P regulators SGPP-1 and SGPL-1 and highlight their contribution to the sphingolipid rheostat in inflammation. Y1 - 2017 U6 - https://doi.org/10.1155/2017/5187368 SN - 0962-9351 SN - 1466-1861 PB - Hindawi Publishing Corp. CY - London ER - TY - JOUR A1 - Yue, Jinxing A1 - Alter, Kai-Uwe A1 - Howard, David A1 - Bastiaanse, Roelien T1 - Early access to lexical-level phonological representations of Mandarin word-forms BT - evidence from auditory N1 habituation JF - Language, cognition and neuroscience N2 - An auditory habituation design was used to investigate whether lexical-level phonological representations in the brain can be rapidly accessed after the onset of a spoken word. We studied the N1 component of the auditory event-related electrical potential, and measured the amplitude decrements of N1 associated with the repetition of a monosyllabic tone word and an acoustically similar pseudo-word in Mandarin Chinese. Effects related to the contrastive onset consonants were controlled for by introducing two control words. We show that repeated pseudo-words consistently elicit greater amplitude decrements in N1 than real words. Furthermore, this lexicality effect is free from sensory fatigue or rapid learning of the pseudo-word. These results suggest that a lexical-level phonological representation of a spoken word can be accessed as early as 110ms after the onset of the word-form. KW - Auditory N1 KW - short-term habituation KW - spoken word KW - Mandarin Chinese KW - language KW - event-related potential KW - lexical access Y1 - 2017 U6 - https://doi.org/10.1080/23273798.2017.1290261 SN - 2327-3798 SN - 2327-3801 VL - 32 IS - 9 SP - 1148 EP - 1163 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - You, Zewang A1 - Behl, Marc A1 - Löwenberg, Candy A1 - Lendlein, Andreas T1 - pH-sensitivity and conformation change of the n-terminal methacrylated peptide VK20 JF - MRS advances : a journal of the Materials Research Society (MRS) N2 - N-terminal methacrylation of peptide MAXI, which is capable of conformational changes variation of the pH, results in a peptide, named VK20. Increasing the reactivity of this terminal group enables further coupling reactions or chemical modifications of the peptidc. However, this end group functionalization may influence the ability of confonnational changes of VK20; as well as its properties. In this paper; the influence of pH on the transition between random coil and beta-sheet conformation of VK20; including the transition kinetics, were investigated. At pH values of 9 and higher, the kinetics beta-sheet formation increased tor VK(2 0, compared to MAXI. The self-assembly into beta-sheets recognized by the formation of a physically crosslinked gel was furthermore indicated by a significant increase of G. An increase in pH (from 9 to 9.5) led to a faster gelation of the peptide VK20. Simultaneously, G was increased from 460 +/- 70 Pa (at pH 9) to 1520 +/- 180 Pa (at pH 9.5). At the nanoscale, the gel showed a highly interconnected fibrillar/network structure with uniform fibril widths of approximately 3.4 +/- 0.5 nm (N=30). The recovery of the peptide conformation back to random coil resulted in the dissolution of the gel; whereby the kinetics of the recovery depended on the pH. Conclusively, the ability of MAXI to undergo confommtional changes was not affected by N-terminal methacrylation whereas the kinetics of pH-sensitive beta-sheet formations has been increased. Y1 - 2017 U6 - https://doi.org/10.1557/adv.2017.491 SN - 2059-8521 VL - 2 SP - 2571 EP - 2579 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Muthaura, Charles N. A1 - Keriko, Joseph M. A1 - Mutai, Charles A1 - Yenesew, Abiy A1 - Heydenreich, Matthias A1 - Atilaw, Yoseph A1 - Gathirwa, Jeremiah W. A1 - Irungu, Beatrice N. A1 - Derese, Solomon T1 - Antiplasmodial, cytotoxicity and phytochemical constituents of four maytenus species used in traditional medicine in Kenya JF - The natural products journal N2 - Background: In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. putterlickioides, M. senegalensis and M. heterophylla were evaluated to determine compound/s responsible for antimalarial activity. Objective: To isolate antiplasmodial compounds from these plant species which could be used as marker compounds in the standardization of their extracts as a phytomedicine for malaria. Methods: Constituents were isolated through activity-guided fractionation of the MeOH/CHCl3 (1:1) extracts and in vitro inhibition of Plasmodium falciparum. Cytotoxicity was evaluated using Vero cells and the compounds were elucidated on the basis of NMR spectroscopy. Results: Fractionation of the extracts resulted in the isolation of ten known compounds. Compound 1 showed promising antiplasmodial activity with IC50, 3.63 and 3.95 ng/ml against chloroquine sensitive (D6) and resistant (W2) P. falciparum, respectively and moderate cytotoxicity (CC50, 37.5 ng/ml) against Vero E6 cells. The other compounds showed weak antiplasmodial (IC50 > 1.93 mu g/ml) and cytotoxic (CC50 > 39.52 mu g/ml) activities against P. falciparum and Vero E6 cells, respectively. Conclusion: (20 alpha)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylic acid-(29)-methyl-ester (pristimerin) (1) was the most active marker and lead compound that warrants further investigation as a template for the development of new antimalarial drugs. Pristimerin is reported for the first time in M. putterlickioides. 3-Hydroxyolean-12-en-28-oic acid (oleanolic acid) (5), stigmast-5-en-3-ol (beta-sitosterol) (6), 3-oxo-28-friedelanoic acid (7), olean-12-en-3-ol (beta-amyrin) (8), lup-20(29)-en-3-ol (lupeol) (9) and lup-20(29)-en-3-one (lupenone) (10) are reported for the first time in M. undata. KW - Antimalarial plants KW - antiplasmodial KW - cytotoxicity KW - marker compound KW - Maytenus spp. KW - phytomedicine KW - pristimerin Y1 - 2017 U6 - https://doi.org/10.2174/2210315507666161206144050 SN - 2210-3155 SN - 2210-3163 VL - 7 IS - 2 SP - 144 EP - 152 PB - Bentham Science Publ. CY - Sharjah ER - TY - JOUR A1 - Fyndanis, Valantis A1 - Lind, Marianne A1 - Varlokosta, Spyridoula A1 - Kambanaros, Maria A1 - Soroli, Efstathia A1 - Ceder, Klaudia A1 - Grohmann, Kleanthes K. A1 - Rofes, Adrià A1 - Simonsen, Hanne Gram A1 - Bjekić, Jovana A1 - Gavarró, Anna A1 - Kraljević, Jelena Kuvač A1 - Martínez-Ferreiro, Silvia A1 - Munarriz, Amaia A1 - Pourquie, Marie A1 - Vuksanović, Jasmina A1 - Zakariás, Lilla A1 - Howard, David T1 - Cross-linguistic adaptations of The Comprehensive Aphasia Test BT - challenges and solutions JF - Clinical linguistics & phonetics N2 - Comparative research on aphasia and aphasia rehabilitation is challenged by the lack of comparable assessment tools across different languages. In English, a large array of tools is available, while in most other languages, the selection is more limited. Importantly, assessment tools are often simple translations and do not take into consideration specific linguistic and psycholinguistic parameters of the target languages. As a first step in meeting the needs for comparable assessment tools, the Comprehensive Aphasia Test is currently being adapted into a number of languages spoken in Europe. In this article, some key challenges encountered in the adaptation process and the solutions to ensure that the resulting assessment tools are linguistically and culturally equivalent, are proposed. Specifically, we focus on challenges and solutions related to the use of imageability, frequency, word length, spelling-to-sound regularity and sentence length and complexity as underlying properties in the selection of the testing material. KW - Aphasia KW - assessment KW - Comprehensive Aphasia Test (CAT) KW - cross-linguistic adaptations KW - outcome measures Y1 - 2017 U6 - https://doi.org/10.1080/02699206.2017.1310299 SN - 0269-9206 SN - 1464-5076 VL - 31 IS - 7-9 SP - 697 EP - 710 PB - Taylor & Francis Group CY - Philadelphia ER - TY - JOUR A1 - Chang, Der-Chen A1 - Hedayat Mahmoudi, Mahdi A1 - Schulze, Bert-Wolfgang T1 - Singular degenerate operators JF - Applicable analysis : an international journal N2 - We outline some simplified and more general method for constructing parametrices on higher singular spaces. We also outline basic ideas on operators on manifolds with conical or edge singularities. KW - Operators on singular cones KW - Mellin symbols with values in the edge calculus KW - parametrices of elliptic operators Y1 - 2017 U6 - https://doi.org/10.1080/00036811.2017.1336546 SN - 0003-6811 SN - 1563-504X VL - 96 IS - 14 SP - 2434 EP - 2456 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Balta Beylergil, Sinem A1 - Beck, Anne A1 - Deserno, Lorenz A1 - Lorenz, Robert C. A1 - Rapp, Michael A. A1 - Schlagenhauf, Florian A1 - Heinz, Andreas A1 - Obermayer, Klaus T1 - Dorsolateral prefrontal cortex contributes to the impaired behavioral adaptation in alcohol dependence JF - NeuroImage: Clinical : a journal of diseases affecting the nervous system N2 - Substance-dependent individuals often lack the ability to adjust decisions flexibly in response to the changes in reward contingencies. Prediction errors (PEs) are thought to mediate flexible decision-making by updating the reward values associated with available actions. In this study, we explored whether the neurobiological correlates of PEs are altered in alcohol dependence. Behavioral, and functional magnetic resonance imaging (fMRI) data were simultaneously acquired from 34 abstinent alcohol-dependent patients (ADP) and 26 healthy controls (HC) during a probabilistic reward-guided decision-making task with dynamically changing reinforcement contingencies. A hierarchical Bayesian inference method was used to fit and compare learning models with different assumptions about the amount of task-related information subjects may have inferred during the experiment. Here, we observed that the best-fitting model was a modified Rescorla-Wagner type model, the “double-update” model, which assumes that subjects infer the knowledge that reward contingencies are anti-correlated, and integrate both actual and hypothetical outcomes into their decisions. Moreover, comparison of the best-fitting model's parameters showed that ADP were less sensitive to punishments compared to HC. Hence, decisions of ADP after punishments were loosely coupled with the expected reward values assigned to them. A correlation analysis between the model-generated PEs and the fMRI data revealed a reduced association between these PEs and the BOLD activity in the dorsolateral prefrontal cortex (DLPFC) of ADP. A hemispheric asymmetry was observed in the DLPFC when positive and negative PE signals were analyzed separately. The right DLPFC activity in ADP showed a reduced correlation with positive PEs. On the other hand, ADP, particularly the patients with high dependence severity, recruited the left DLPFC to a lesser extent than HC for processing negative PE signals. These results suggest that the DLPFC, which has been linked to adaptive control of action selection, may play an important role in cognitive inflexibility observed in alcohol dependence when reinforcement contingencies change. Particularly, the left DLPFC may contribute to this impaired behavioral adaptation, possibly by impeding the extinction of the actions that no longer lead to a reward. KW - Alcohol dependence KW - Prediction error KW - Reinforcement learning KW - Reversal learning KW - Dorsolateral prefrontal cortex KW - Decision-making Y1 - 2017 U6 - https://doi.org/10.1016/j.nicl.2017.04.010 SN - 2213-1582 VL - 15 SP - 80 EP - 94 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Kaufmann, Yvonne Marie A1 - Maiwald, Lisa Marie A1 - Schindler, Svenja A1 - Weck, Florian T1 - Wie wirkt sich mehrmaliges Kompetenz-Feedback auf psychotherapeutische Behandlungen aus? T1 - How does multiple competence feedback affect psychotherapeutic treatment? BT - eine qualitative Analyse BT - a qualitative analysis JF - Zeitschrift für klinische Psychologie und Psychotherapie : Forschung und Praxis N2 - Theoretischer Hintergrund: Einflüsse von therapeutenorientiertem Kompetenz-Feedback in der Psychotherapieausbildung wurden bislang wenig untersucht. Fragestellung: Wie gehen Ausbildungstherapeuten mit Feedback um? Welchen Einfluss hat ein regelmäßiges Kompetenz-Feedback auf die Qualität psychotherapeutischer Behandlungen (insbesondere Therapiesitzungen, therapeutische Beziehung, Person des Therapeuten, Supervision)? Methode: Elf Therapeuten wurden mithilfe eines halbstrukturierten Interviewleitfadens befragt. Die Auswertung erfolgte mittels qualitativer Inhaltsanalyse nach Mayring (2015). Ergebnisse: Das auf Basis der Interviews erstellte Kategoriensystem umfasste die Kategorien „Erwartungen an das Feedback“, „Wahrnehmung des Feedbacks“, „Verarbeitung von und Umgang mit Feedback“, „Folgen, Auswirkungen und Veränderungen durch Feedback“ sowie „Verbesserungswünsche“. Schlussfolgerungen: Therapeuten streben eine Umsetzung des Feedbacks an, welches sich auf die Behandlung, die Supervision, die eigene Person und die therapeutische Beziehung auswirkt. N2 - Background: To date, the influence of therapist-oriented feedback in psychotherapy training has rarely been investigated. Objective: How do therapists in training deal with competence feedback? What influence does a regular competence feedback have on treatment quality (especially therapy sessions, therapeutic alliance, the therapist, supervision)? Method: We interviewed 11 therapists using a semistructured interview guide. The text material was analyzed with qualitative content analysis (Mayring, 2015). Results: The interview-based system of categories consists of: expectations toward feedback; perception of feedback; processing of feedback; consequences, effects, and changes due to feedback; and suggestions for improvement. Conclusion: Therapists strive to implement feedback. Competence feedback has an impact on treatment, supervision, the therapist, and the therapeutic alliance. KW - feedback KW - psychotherapy training KW - psychotherapeutic competencies KW - qualitative content analysis KW - clinical supervision Y1 - 2017 U6 - https://doi.org/10.1026/1616-3443/a000412 SN - 1616-3443 SN - 2190-6297 VL - 46 IS - 2 SP - 96 EP - 106 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Peng, Xingzhou A1 - Behl, Marc A1 - Zhang, Pengfei A1 - Mazurek-Budzyńska, Magdalena A1 - Feng, Yakai A1 - Lendlein, Andreas T1 - Synthesis and characterization of multiblock poly(ester-amide-urethane)s JF - MRS advances : a journal of the Materials Research Society (MRS) N2 - In this study, a multiblock copolymer containing oligo(3-methyl-morpholine-2, 5-dione) (oMMD) and oligo(3-sec-butyl-morpholine-2, 5-dione) (oBMD) building blocks obtained by ring-opening polymerization (ROP) of the corresponding monomers, was synthesized in a polyaddition reaction using an aliphatic diisocyanate. The multiblock copolymer (pBMD-MMD) provided a molecular weight of 40, 000 g·mol−1, determined by gel permeation chromatography (GPC). Incorporation of both oligodepsipeptide segments in multiblock copolymers was confirmed by 1H NMR and Matrix Assisted Laser Desorption/Ionization Time Of Flight Mass Spectroscopy (MALDI-TOF MS) analysis. pBMD-MMD showed two separated glass transition temperatures (61 °C and 74 °C) indicating a microphase separation. Furthermore, a broad glass transition was observed by DMTA, which can be attributed to strong physical interaction i.e. by H-bonds formed between amide, ester, and urethane groups of the investigated copolymers. The obtained multiblock copolymer is supposed to own the capability to exhibit strong physical interactions. Y1 - 2017 U6 - https://doi.org/10.1557/adv.2017.486 SN - 2059-8521 VL - 2 SP - 2551 EP - 2559 PB - Cambridge University Press CY - Cambridge ER - TY - JOUR A1 - Buschhüter, David A1 - Spoden, Christian A1 - Borowski, Andreas T1 - Physics knowledge of first semester physics students in Germany BT - a comparison of 1978 and 2013 cohorts JF - International journal of science education N2 - Over the last decades, the percentage of the age group choosing to pursue university studies has increased significantly across the world. At the same time, there are university teachers who believe that the standards have fallen. There is little research on whether students nowadays demonstrate knowledge or abilities similar to that of the preceding cohorts. However, in times of educational expansion, empirical evidence on student test performance is extremely helpful in evaluating how well educational systems cope with the increasing numbers of students. In this study, we compared a sample of 2322 physics freshmen from 2013 with another sample of 2718 physics freshmen from 1978 at universities in Germany with regard to their physics knowledge based on their results in the same entrance test. Previous results on mathematics knowledge and abilities in the same sample of students indicated that there was no severe decline in their average achievement. This paper compares the physics knowledge of the same two samples of students. Contrary to their mathematics results, their physics results showed a substantial decrease in physics knowledge as measured by the test. KW - University physics KW - entrance test KW - generational comparison Y1 - 2017 U6 - https://doi.org/10.1080/09500693.2017.1318457 SN - 0950-0693 SN - 1464-5289 VL - 39 IS - 9 SP - 1109 EP - 1132 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Yılmaz, Zafer T1 - The AKP and the spirit of the ‘new’ Turkey BT - imagined victim, reactionary mood, and resentful sovereign JF - Turkish studies N2 - A strong sense of victimhood, a discourse of social suffering, and complementary bodily performances, which mobilize rancor, resentfulness, and revengefulness, are fundamental elements of Turkish-Islamist ideology. This article discusses the political dynamics and implications of such assertions of victimhood in the Turkish context. To underscore these dynamics, it analyses the role of the logic of pain in the subject formation of Turkish-Islamist identity and how this logic has been revitalized by constitutive and hegemonic social imagination, and circulated and intensified by a reactionary mood. Additionally, it aims to expose how this reactionary mood profoundly depends on contradictory subjectification processes, which simultaneously involve mobilization of feelings of impotency, non-responsibility, self-pitying, and sublimation of power. This subject formation opens the way for identification with authoritarian figures in the Turkish case. KW - Justice and Development Party (AKP) KW - victimhood KW - resentment KW - reactionary mood KW - Turkish-Islamist ideology Y1 - 2017 U6 - https://doi.org/10.1080/14683849.2017.1314763 SN - 1468-3849 SN - 1743-9663 VL - 18 IS - 3 SP - 482 EP - 513 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Muschalla, Beate T1 - Work-anxiety-coping intervention improves work-coping perception while a recreational intervention leads to deterioration BT - results from a randomized controlled trial JF - European journal of work and organizational psychology : the official journal of The European Association of Work and Organizational Psychology N2 - Work-anxieties are costly and need early intervention. The perception of being able to cope with work is a basic requirement for work ability. This randomized controlled trial investigates whether a cognitive behavioural, work-anxiety-coping group (WAG) intervention leads to better work-coping perception than an unspecific recreational group (RG). Heterogeneous people in medical rehabilitation, who were due to return to work, were interviewed concerning their work-anxieties, and either randomly assigned to a WAG (n=85) or a RG (n=95). The participants (with an average of 50years old [range 23-64]; 51% women; 70% workers or employees, 25% academics, 5% unskilled) followed the group intervention for four or six sessions. The perceived work-coping was assessed by self-rating (Inventory for Job-Coping and Return Intention JoCoRi) after each group session. Although participants had a slight temporary decrease in work-coping after group session two (from M-1=2.47 to M-2=2.28, d(Cohen)=-.22), the WAG led to the improvement of perceived work-coping over the intervention course (from M-1=2.47 to M-6=2.65, d(Cohen)=.18). In contrast, participants from the RG reported lower work-coping after six group sessions (from M-1=2.26 to M-6=2.02, d(Cohen)=-.18). It is considered that people with work-anxieties need training in work-coping. By focusing on recreation only, this may lead to deterioration of work-coping. Indeed, intervention designers should be aware of temporary deterioration (side effects) when confronting participants with work-coping. KW - Work-anxiety KW - work-coping KW - return to work KW - intervention KW - mental health Y1 - 2017 U6 - https://doi.org/10.1080/1359432X.2017.1384378 SN - 1359-432X SN - 1464-0643 VL - 26 IS - 6 SP - 858 EP - 869 PB - Taylor & Francis CY - Abingdon ER -