TY - JOUR A1 - Nied, Manuela A1 - Schröter, Kai A1 - Lüdtke, Stefan A1 - Nguyen, Viet Dung A1 - Merz, Bruno T1 - What are the hydro-meteorological controls on flood characteristics? JF - Journal of hydrology N2 - Flood events can be expressed by a variety of characteristics such as flood magnitude and extent, event duration or incurred loss. Flood estimation and management may benefit from understanding how the different flood characteristics relate to the hydrological catchment conditions preceding the event and to the meteorological conditions throughout the event. In this study, we therefore propose a methodology to investigate the hydro-meteorological controls on different flood characteristics, based on the simulation of the complete flood risk chain from the flood triggering precipitation event, through runoff generation in the catchment, flood routing and possible inundation in the river system and floodplains to flood loss. Conditional cumulative distribution functions and regression tree analysis delineate the seasonal varying flood processes and indicate that the effect of the hydrological pre-conditions, i.e. soil moisture patterns, and of the meteorological conditions, i.e. weather patterns, depends on the considered flood characteristic. The methodology is exemplified for the Elbe catchment. In this catchment, the length of the build-up period, the event duration and the number of gauges undergoing at least a 10-year flood are governed by weather patterns. The affected length and the number of gauges undergoing at least a 2-year flood are however governed by soil moisture patterns. In case of flood severity and loss, the controlling factor is less pronounced. Severity is slightly governed by soil moisture patterns whereas loss is slightly governed by weather patterns. The study highlights that flood magnitude and extent arise from different flood generation processes and concludes that soil moisture patterns as well as weather patterns are not only beneficial to inform on possible flood occurrence but also on the involved flood processes and resulting flood characteristics. KW - Flood KW - Flood duration KW - Flood magnitude KW - Flood loss KW - Soil moisture patterns KW - Antecedent conditions KW - Weather patterns KW - Large basins Y1 - 2017 U6 - https://doi.org/10.1016/j.jhydrol.2016.12.003 SN - 0022-1694 SN - 1879-2707 VL - 545 SP - 310 EP - 326 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Wernicke, Sarah A1 - de Witt Huberts, Jessie A1 - Wippert, Pia-Maria T1 - The pain of being misunderstood BT - Invalidation of pain complaints in chronic low back pain patients JF - Journal of Health Psychology N2 - A particular form of social pain is invalidation. Therefore, this study (a) investigates whether patients with chronic low back pain experience invalidation, (b) if it has an influence on their pain, and (c) explores whether various social sources (e.g. partner and work) influence physical pain differentially. A total of 92 patients completed questionnaires, and for analysis, Pearson’s correlation coefficients and hierarchical linear regression analyses were conducted. They indicated a significant association between discounting and disability due to pain (respective β = .29, p > .05). Especially, discounting by partner was linked to higher disability (β = .28, p > .05). KW - chronic low back pain KW - disability KW - invalidation KW - social pain KW - social rejection Y1 - 2017 U6 - https://doi.org/10.1177/1359105315596371 SN - 1359-1053 SN - 1461-7277 VL - 22 SP - 135 EP - 147 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Esguerra, Alejandro A1 - Beck, Silke A1 - Lidskog, Rolf T1 - Stakeholder Engagement in the Making BT - IPBES Legitimization Politics JF - Global environmental politics N2 - A growing number of expert organizations aim to provide knowledge for global environmental policy-making. Recently, there have also been explicit calls for stakeholder engagement at the global level to make scientific knowledge relevant and usable on the ground. The newly established Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is one of the first international expert organizations to have systematically developed a strategy for stakeholder engagement in its own right. In this article, we analyze the emergence of this strategy. Employing the concept politics of legitimation, we examine how and for what reasons stakeholder engagement was introduced, justified, and finally endorsed, as well as its effects. The article explores the process of institutionalizing stakeholder engagement, as well as reconstructing the contestation of the operative norms (membership, tasks, and accountability) regulating the rules for this engagement. We conclude by discussing the broader importance of the findings for IPBES, as well as for international expert organizations in general. Y1 - 2017 U6 - https://doi.org/10.1162/GLEP_a_00390 SN - 1526-3800 SN - 1536-0091 VL - 17 SP - 59 EP - 76 PB - MIT Press CY - Cambridge ER - TY - JOUR A1 - Eichler, Sarah A1 - Salzwedel, Annett A1 - Reibis, Rona A1 - Nothroff, Jörg A1 - Harnath, Axel A1 - Schikora, Martin A1 - Butter, Christian A1 - Wegscheider, Karl A1 - Völler, Heinz T1 - Multicomponent cardiac rehabilitation in patients after transcatheter aortic valve implantation BT - predictors of functional and psychocognitive recovery JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - Background: In the last decade, transcatheter aortic valve implantation has become a promising treatment modality for patients with aortic stenosis and a high surgical risk. Little is known about influencing factors of function and quality of life during multicomponent cardiac rehabilitation. Methods: From October 2013 to July 2015, patients with elective transcatheter aortic valve implantation and a subsequent inpatient cardiac rehabilitation were enrolled in the prospective cohort multicentre study. Frailty-Index (including cognition, nutrition, autonomy and mobility), Short Form-12 (SF-12), six-minute walk distance (6MWD) and maximum work load in bicycle ergometry were performed at admission and discharge of cardiac rehabilitation. The relation between patient characteristics and improvements in 6MWD, maximum work load or SF-12 scales were studied univariately and multivariately using regression models. Results: One hundred and thirty-six patients (80.6 +/- 5.0 years, 47.8% male) were enrolled. 6MWD and maximum work load increased by 56.3 +/- 65.3 m (p < 0.001) and 8.0 +/- 14.9 watts (p < 0.001), respectively. An improvement in SF-12 (physical 2.5 +/- 8.7, p = 0.001, mental 3.4 +/- 10.2, p = 0.003) could be observed. In multivariate analysis, age and higher education were significantly associated with a reduced 6MWD, whereas cognition and obesity showed a positive predictive value. Higher cognition, nutrition and autonomy positively influenced the physical scale of SF-12. Additionally, the baseline values of SF-12 had an inverse impact on the change during cardiac rehabilitation. Conclusions: Cardiac rehabilitation can improve functional capacity as well as quality of life and reduce frailty in patients after transcatheter aortic valve implantation. An individually tailored therapy with special consideration of cognition and nutrition is needed to maintain autonomy and empower octogenarians in coping with challenges of everyday life. KW - Cardiac rehabilitation KW - TAVI KW - frailty KW - quality of life KW - exercise capacity Y1 - 2017 U6 - https://doi.org/10.1177/2047487316679527 SN - 2047-4873 SN - 2047-4881 VL - 24 IS - 3 SP - 257 EP - 264 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Prieske, Olaf A1 - Aboodarda, Saied J. A1 - Sierra, Jose A. Benitez A1 - Behm, David G. A1 - Granacher, Urs T1 - Slower but not faster unilateral fatiguing knee extensions alter contralateral limb performance without impairment of maximal torque output JF - European journal of applied physiology N2 - The purpose of the present study was to examine the effects of unilateral fatigue of the knee extensors at different movement velocities on neuromuscular performance in the fatigued and non-fatigued leg. Unilateral fatigue of the knee extensors was induced in 11 healthy young men (23.7 +/- 3.8 years) at slower (60A degrees/s; FAT60) and faster movement velocities (240A degrees/s; FAT240) using an isokinetic dynamometer. A resting control (CON) condition was included. The fatigue protocols consisted of five sets of 15 maximal concentric knee extensions using the dominant leg. Before and after fatigue, peak isokinetic torque (PIT) and time to PIT (TTP) of the knee extensors as well as electromyographic (EMG) activity of vastus medialis, vastus lateralis, and biceps femoris muscles were assessed at 60 and 240A degrees/s movement velocities in the fatigued and non-fatigued leg. In the fatigued leg, significantly greater PIT decrements were observed following FAT60 and FAT240 (11-19%) compared to CON (3-4%, p = .002, d = 2.3). Further, EMG activity increased in vastus lateralis and biceps femoris muscle following FAT240 only (8-28%, 0.018 <= p <=.024, d = 1.8). In the non-fatigued leg, shorter TTP values were found after the FAT60 protocol (11-15%, p = .023, d = 2.4). No significant changes were found for EMG data in the non-fatigued leg. The present study revealed that both slower and faster velocity fatiguing contractions failed to show any evidence of cross-over fatigue on PIT. However, unilateral knee extensor fatigue protocols conducted at slower movement velocities (i.e., 60A degrees/s) appear to modulate torque production on the non-fatigued side (evident in shorter TTP values). KW - Electromyography KW - Cross-over fatigue KW - Isokinetic KW - Movement velocity KW - Motor function KW - Central activation Y1 - 2017 U6 - https://doi.org/10.1007/s00421-016-3524-6 SN - 1439-6319 SN - 1439-6327 VL - 117 SP - 323 EP - 334 PB - Springer CY - New York ER - TY - JOUR A1 - Shubchynskyy, Volodymyr A1 - Boniecka, Justyna A1 - Schweighofer, Alois A1 - Simulis, Justinas A1 - Kvederaviciute, Kotryna A1 - Stumpe, Michael A1 - Mauch, Felix A1 - Balazadeh, Salma A1 - Müller-Röber, Bernd A1 - Boutrot, Freddy A1 - Zipfel, Cyril A1 - Meskiene, Irute T1 - Protein phosphatase AP2C1 negatively regulates basal resistance and defense responses to Pseudomonas syringae JF - Journal of experimental botany N2 - Mitogen-activated protein kinases (MAPKs) mediate plant immune responses to pathogenic bacteria. However, less is known about the cell autonomous negative regulatory mechanism controlling basal plant immunity. We report the biological role of Arabidopsis thaliana MAPK phosphatase AP2C1 as a negative regulator of plant basal resistance and defense responses to Pseudomonas syringae. AP2C2, a closely related MAPK phosphatase, also negatively controls plant resistance. Loss of AP2C1 leads to enhanced pathogen-induced MAPK activities, increased callose deposition in response to pathogen-associated molecular patterns or to P. syringae pv. tomato (Pto) DC3000, and enhanced resistance to bacterial infection with Pto. We also reveal the impact of AP2C1 on the global transcriptional reprogramming of transcription factors during Pto infection. Importantly, ap2c1 plants show salicylic acid-independent transcriptional reprogramming of several defense genes and enhanced ethylene production in response to Pto. This study pinpoints the specificity of MAPK regulation by the different MAPK phosphatases AP2C1 and MKP1, which control the same MAPK substrates, nevertheless leading to different downstream events. We suggest that precise and specific control of defined MAPKs by MAPK phosphatases during plant challenge with pathogenic bacteria can strongly influence plant resistance. KW - Callose KW - defense genes KW - MAPK KW - MAPK phosphatase KW - PAMP KW - PP2C phosphatase KW - Pseudomonas syringae KW - salicylic acid KW - transcription factors Y1 - 2017 U6 - https://doi.org/10.1093/jxb/erw485 SN - 0022-0957 SN - 1460-2431 VL - 68 IS - 5 SP - 1169 EP - 1183 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Heunisch, Fabian A1 - Chaykovska, Lyubov A1 - von Einem, Gina A1 - Alter, Markus A1 - Dschietzig, Thomas A1 - Kretschmer, Axel A1 - Kellner, Karl-Heinz A1 - Hocher, Berthold T1 - ADMA predicts major adverse renal events in patients with mild renal impairment and/or diabetes mellitus undergoing coronary angiography JF - Medicine N2 - Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of the nitric oxide (NO)-synthase and a biomarker of endothelial dysfunction (ED). ED plays an important role in the pathogenesis of contrast-induced nephropathy (CIN). The aim of our study was to evaluate serum ADMA concentration as a biomarker of an acute renal damage during the follow-up of 90 days after contrast medium (CM) application. Blood samples were obtained from 330 consecutive patients with diabetes mellitus or mild renal impairment immediately before, 24 and 48 hours after the CM application for coronary angiography. The patients were followed for 90 days. The composite endpoints were major adverse renal events (MARE) defined as occurrence of death, initiation of dialysis, or a doubling of serum creatinine concentration. Overall, ADMA concentration in plasma increased after CM application, although, there was no differences between ADMA levels in patients with and without CIN. ADMA concentration 24 hours after the CM application was predictive for dialysis with a specificity of 0.889 and sensitivity of 0.653 at values higher than 0.71 mu mol/L (area under the curve: 0.854, 95% confidential interval: 0.767-0.941, P<0.001). This association remained significant in multivariate Cox regression models adjusted for relevant factors of long-term renal outcome. 24 hours after the CM application, ADMA concentration in plasma was predictive for MARE with a specificity of 0.833 and sensitivity of 0.636 at a value of more than 0.70 mu mol/L (area under the curve: 0.750, 95% confidence interval: 0.602-0.897, P=0.004). Multivariate logistic regression analysis confirmed that ADMA and anemia were significant predictors of MARE. Further analysis revealed that increased ADMA concentration in plasma was highly significant predictor of MARE in patients with CIN. Moreover, patients with CIN and MARE had the highest plasma ADMA levels 24 hours after CM exposure in our study cohort. The impact of ADMA on MARE was independent of such known CIN risk factors as anemia, pre-existing renal failure, pre-existing heart failure, and diabetes. ADMA concentration in plasma is a promising novel biomarker of major contrast-induced nephropathy-associated events 90 days after contrast media exposure. KW - asymmetric dimethylarginine (ADMA) KW - biomarkers of renal failure KW - contrast-induced nephropathy Y1 - 2017 U6 - https://doi.org/10.1097/MD.0000000000006065 SN - 0025-7974 SN - 1536-5964 VL - 96 IS - 6 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Eppner, Sebastian A1 - Ganghof, Steffen T1 - Institutional veto players and cabinet formation BT - the veto control hypothesis reconsidered JF - European journal of political research : official journal of the European Consortium for Political Research N2 - Are potential cabinets more likely to form when they control institutional veto players such as symmetric second chambers or minority vetoes? Existing evidence for a causal effect of veto control has been weak. This article presents evidence for this effect on the basis of conditional and mixed logit analyses of government formations in 21 parliamentary and semi-presidential democracies between 1955 and 2012. It also shows that the size of the effect varies systematically across political-institutional contexts. The estimated causal effect was greater in countries that eventually abolished the relevant veto institutions. It is suggested that the incidence of constitutional reform is a proxy for context-specific factors that increased the incentives for veto control and simultaneously provided a stimulus for the weakening of institutional veto power. KW - government formation KW - veto players KW - second chambers Y1 - 2016 U6 - https://doi.org/10.1111/1475-6765.12172 SN - 0304-4130 SN - 1475-6765 VL - 56 IS - 1 SP - 169 EP - 186 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Apelt, Maja A1 - Besio, Cristina A1 - Corsi, Giancarlo A1 - von Groddeck, Victoria A1 - Grothe-Hammer, Michael A1 - Tacke, Veronika T1 - Resurrecting organization without renouncing society BT - a response to Ahrne, Brunsson and Seidl JF - European management journal N2 - In a recent article in this journal, Ahrne, Brunsson, and Seidl (2016) suggest a definition of organization as a ‘decided social order’ composed of five elements (membership, rules, hierarchies, monitoring, and sanctions) which rest on decisions. ‘Partial organization’ uses only one or a few of these decidable elements while ‘complete organization’ uses them all. Such decided orders may also occur outside formal organizations, as the authors observe. Although we appreciate the idea of improving our understanding of organization(s) in modern society, we believe that Ahrne, Brunsson, and Seidl's suggestion jeopardizes the concept of organization by blurring its specific meaning. As the authors already draw on the work of Niklas Luhmann, we propose taking this exploration a step further and the potential of systems theory more seriously. Organizational analysis would then be able to retain a distinctive notion of formal organization on the one hand while benefiting from an encompassing theory of modern society on the other. With this extended conceptual framework, we would expect to gain a deeper understanding of how organizations implement and shape different societal realms as well as mediate between their particular logics, and, not least, how they are related to non-organizational social forms (e.g. families). KW - Partial organization KW - Formal organization KW - Organization theory KW - Niklas KW - Luhmann KW - Functional differentiation KW - Organizations and society Y1 - 2017 U6 - https://doi.org/10.1016/j.emj.2017.01.002 SN - 0263-2373 SN - 1873-5681 VL - 35 IS - 1 SP - 8 EP - 14 PB - Elsevier Science CY - Oxford ER - TY - JOUR A1 - Hoffmann, Svenja A1 - Warschburger, Petra T1 - Weight, shape, and muscularity concerns in male and female adolescents BT - predictors of change and influences on eating concern JF - The international journal of eating disorders N2 - Objective: The purpose of this study was to examine the impact of age and weight status on adolescents' body dissatisfaction and its change over 20 months in a gender-comparing design. The influence of body image concern on eating concern was also investigated. Method: In a prospective study, 675 male and female adolescents aged 12–16 were assessed using self-report questionnaires on weight, shape, muscularity, and eating concerns. Height and weight measurements were taken by trained personnel. Data were analyzed using structural equation modeling. Results: Analyses of latent means revealed more pronounced weight/shape concern in females than males and more pronounced muscularity concern in males than females. Weight/shape concern increased in females over time, whereas muscularity concern remained stable in both genders. Baseline levels of weight/shape concern could be predicted by age and weight status in females and by weight status in males. The only predictor of change in weight/shape concern was weight status in males. Baseline levels of muscularity concern could be predicted by age in females and by weight status in males. Similar effects were found for changes in muscularity concern in both genders. Increases in weight/shape and muscularity concern were associated with more pronounced eating concern. Discussion: The results confirm gender differences in distinctive facets of body image concern and its prediction. The relevance of increase in body image concern in adolescents is underlined by its association with eating concern in both genders. Further explanatory variables for change in body dissatisfaction should be examined in future studies. KW - weight and shape concern KW - muscularity concern KW - eating concern KW - gender KW - adolescence KW - prospective Y1 - 2016 U6 - https://doi.org/10.1002/eat.22635 SN - 0276-3478 SN - 1098-108X VL - 50 IS - 2 SP - 139 EP - 147 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Penk, Christiane A1 - Richter, Dirk T1 - Erratum to: Penk, Christiane, Richter, Dirk: Change in test-taking motivation and its relationship to test performance in low-stakes assessments. - (Educational Assessment, Evaluation and Accountability. - 29 (2017), S. 55 – 79. - doi.org/10.1007/s11092-016-9248-7) T2 - Educational assessment, evaluation and accountability Y1 - 2016 U6 - https://doi.org/10.1007/s11092-016-9249-6 SN - 1874-8597 SN - 1874-8600 VL - 29 SP - 81 EP - 82 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Penk, Christiane A1 - Richter, Dirk T1 - Change in test-taking motivation and its relationship to test performance in low-stakes assessments JF - Educational assessment, evaluation and accountability N2 - Since the turn of the century, an increasing number of low-stakes assessments (i.e., assessments without direct consequences for the test-takers) are being used to evaluate the quality of educational systems. Internationally, research has shown that low-stakes test results can be biased due to students’ low test-taking motivation and that students’ effort levels can vary throughout a testing session involving both cognitive and noncognitive tests. Thus, it is possible that students’ motivation varies throughout a single cognitive test and in turn affects test performance. This study examines the change in test-taking motivation within a 2-h cognitive low-stakes test and its association with test performance. Based on expectancy-value theory, we assessed three components of test-taking motivation (expectancy for success, value, and effort) and investigated its change. Using data from a large-scale student achievement study of German ninth-graders, we employed second-order latent growth modeling and structural equation modeling to predict test performance in mathematics. On average, students’ effort and perceived value of the test decreased, whereas expectancy for success remained stable. Overall, initial test-taking motivation was a better predictor of test performance than change in motivation. Only the variability of change in the expectancy component was positively related to test performance. The theoretical and practical implications for test practitioners are discussed. KW - Test-taking motivation KW - Low-stakes tests KW - Large-scale assessments KW - Expectancy-value theory KW - Growth modeling Y1 - 2016 U6 - https://doi.org/10.1007/s11092-016-9248-7 SN - 1874-8597 SN - 1874-8600 VL - 29 SP - 55 EP - 79 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Sun, Ning-Chen A1 - de Grijs, Richard A1 - Subramanian, Smitha A1 - Cioni, Maria-Rosa L. A1 - Rubele, Stefano A1 - Bekki, Kenji A1 - Ivanov, Valentin D. A1 - Piatti, Andrés E. A1 - Ripepi, Vincenzo T1 - The VMC Survey. XXII. Hierarchical star formation in the 30 Doradus-N158-N159-N160 star-forming complex JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - We study the hierarchical stellar structures in a similar to 1.5 deg(2) area covering the 30. Doradus-N158-N159-N160 starforming complex with the VISTA Survey of. Magellanic Clouds. Based on the young upper main-sequence stars, we find that the surface densities cover a wide range of values, from log(Sigma.pc(2))less than or similar to -2.0 to log(Sigma. pc(2)) greater than or similar to 0.0. Their distributions are highly non-uniform, showing groups that frequently have subgroups inside. The sizes of the stellar groups do not exhibit characteristic values, and range continuously from several parsecs to more than 100. pc; the cumulative size distribution can be well described by a single power law, with the power-law index indicating a projected fractal dimension D-2 = 1.6 +/- 0.3. We suggest that the phenomena revealed here support a scenario of hierarchical star formation. Comparisons with other star-forming regions and galaxies are also discussed. KW - galaxies: clusters: general KW - infrared: stars KW - Magellanic Clouds KW - stars: formation Y1 - 2017 U6 - https://doi.org/10.3847/1538-4357/835/2/171 SN - 0004-637X SN - 1538-4357 VL - 835 IS - 2 PB - Institute of Physics Publ. CY - Bristol ER - TY - JOUR A1 - Koopman, Wouter-Willem Adriaan A1 - Natali, Marco A1 - Donati, Giovanni P. A1 - Muccini, Michele A1 - Toffanin, Stefano T1 - Charge-exciton interaction rate in organic field-effect transistors by means of transient photoluminescence electromodulated spectroscopy JF - ACS photonics N2 - Organic light-emitting transistors (OLETs) offer a huge potential for the design of highly integrated multifunctional optoelectronic systems and of intense nano scale light sources, such as the long-searched-for electrically pumped organic laser. In order to fulfill these promises, the efficiency and brightness of the current state-of-the-art devices have to be increased significantly. The dominating quenching process limiting the external quantum efficiency in OLETs is charge-exciton interaction. A comprehensive understanding of this quenching process is therefore of paramount importance. The present article reports a systematic investigation of charge-exciton interaction in organic transistors employing time resolved photoluminescence electro-modulation (PLEM) spectroscopy on the picosecond time scale. The results show that the injected charges reduce the exciton radiative recombination in two ways: (i) charges may prevent the generation of excitons and (ii) charges activate a further nonradiative channel for the exciton decay. Moreover, the transient PLEM measurements clearly reveal that not only trapped charges, as already reported in literature, but rather the entire injected charge density contributes to the quenching of the exciton population. KW - photoluminescence quenching KW - charge density KW - exciton dynamics KW - organic KW - field-effect transistor KW - light emission KW - optical spectroscopy Y1 - 2017 U6 - https://doi.org/10.1021/acsphotonics.6b00573 SN - 2330-4022 VL - 4 IS - 2 SP - 282 EP - 291 PB - American Chemical Society CY - Washington, DC ER - TY - GEN A1 - George, Elizabeth A1 - Kearney, Eric T1 - Editorial T2 - Organizational psychology review Y1 - 2017 U6 - https://doi.org/10.1177/2041386617690945 SN - 2041-3866 SN - 2041-3874 VL - 7 IS - 1 SP - 3 EP - 3 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Rackwitz, Jenny A1 - Ranković, Miloš Lj. A1 - Milosavljević, Aleksandar R. A1 - Bald, Ilko T1 - A novel setup for the determination of absolute cross sections for low-energy electron induced strand breaks in oligonucleotides BT - the effect of the radiosensitizer 5-fluorouracil* JF - The European physical journal : D, Atomic, molecular, optical and plasma physics N2 - Low-energy electrons (LEEs) play an important role in DNA radiation damage. Here we present a method to quantify LEE induced strand breakage in well-defined oligonucleotide single strands in terms of absolute cross sections. An LEE irradiation setup covering electron energies <500 eV is constructed and optimized to irradiate DNA origami triangles carrying well-defined oligonucleotide target strands. Measurements are presented for 10.0 and 5.5 eV for different oligonucleotide targets. The determination of absolute strand break cross sections is performed by atomic force microscopy analysis. An accurate fluence determination ensures small margins of error of the determined absolute single strand break cross sections sigma SSB. In this way, the influence of sequence modification with the radiosensitive 5-Fluorouracil (U-5F) is studied using an absolute and relative data analysis. We demonstrate an increase in the strand break yields of U-5F containing oligonucleotides by a factor of 1.5 to 1.6 compared with non-modified oligonucleotide sequences when irradiated with 10 eV electrons. Y1 - 2017 U6 - https://doi.org/10.1140/epjd/e2016-70608-4 SN - 1434-6060 SN - 1434-6079 VL - 71 PB - Springer CY - New York ER - TY - JOUR A1 - Almeida, Leonardo A. A1 - Sana, H. A1 - Taylor, W. A1 - Barbá, Rodolfo A1 - Bonanos, Alceste Z. A1 - Crowther, Paul A1 - Damineli, Augusto A1 - de Koter, A. A1 - de Mink, Selma E. A1 - Evans, C. J. A1 - Gieles, Mark A1 - Grin, Nathan J. A1 - Hénault-Brunet, V. A1 - Langer, Norbert A1 - Lennon, D. A1 - Lockwood, Sean A1 - Maíz Apellániz, Jesús A1 - Moffat, A. F. J. A1 - Neijssel, C. A1 - Norman, C. A1 - Ramírez-Agudelo, O. H. A1 - Richardson, N. D. A1 - Schootemeijer, Abel A1 - Shenar, Tomer A1 - Soszyński, Igor A1 - Tramper, Frank A1 - Vink, J. S. T1 - The tarantula massive binary monitoring BT - I. Observational campaign and OB-type spectroscopic binaries JF - Astronomy and astrophysics : an international weekly journal N2 - Context: Massive binaries play a crucial role in the Universe. Knowing the distributions of their orbital parameters is important for a wide range of topics from stellar feedback to binary evolution channels and from the distribution of supernova types to gravitational wave progenitors, yet no direct measurements exist outside the Milky Way. Aims: The Tarantula Massive Binary Monitoring project was designed to help fill this gap by obtaining multi-epoch radial velocity (RV) monitoring of 102 massive binaries in the 30 Doradus region. Methods: In this paper we analyze 32 FLAMES/GIRAFFE observations of 93 O- and 7 B-type binaries. We performed a Fourier analysis and obtained orbital solutions for 82 systems: 51 single-lined (SB1) and 31 double-lined (SB2) spectroscopic binaries. Results: Overall, the binary fraction and orbital properties across the 30 Doradus region are found to be similar to existing Galactic samples. This indicates that within these domains environmental effects are of second order in shaping the properties of massive binary systems. A small difference is found in the distribution of orbital periods, which is slightly flatter (in log space) in 30 Doradus than in the Galaxy, although this may be compatible within error estimates and differences in the fitting methodology. Also, orbital periods in 30 Doradus can be as short as 1.1 d, somewhat shorter than seen in Galactic samples. Equal mass binaries (q> 0.95) in 30 Doradus are all found outside NGC 2070, the central association that surrounds R136a, the very young and massive cluster at 30 Doradus’s core. Most of the differences, albeit small, are compatible with expectations from binary evolution. One outstanding exception, however, is the fact that earlier spectral types (O2–O7) tend to have shorter orbital periods than later spectral types (O9.2–O9.7). Conclusions: Our results point to a relative universality of the incidence rate of massive binaries and their orbital properties in the metallicity range from solar (Z⊙) to about half solar. This provides the first direct constraints on massive binary properties in massive star-forming galaxies at the Universe’s peak of star formation at redshifts z ~ 1 to 2 which are estimated to have Z ~ 0.5 Z⊙. KW - stars: early-type KW - stars: massive KW - binaries: spectroscopic KW - binaries: close Y1 - 2017 U6 - https://doi.org/10.1051/0004-6361/201629844 SN - 1432-0746 VL - 598 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Shenar, Tomer A1 - Richardson, N. D. A1 - Sablowski, Daniel P. A1 - Hainich, Rainer A1 - Sana, H. A1 - Moffat, A. F. J. A1 - Todt, Helge Tobias A1 - Hamann, Wolf-Rainer A1 - Oskinova, Lidia M. A1 - Sander, Andreas Alexander Christoph A1 - Tramper, Frank A1 - Langer, Norbert A1 - Bonanos, Alceste Z. A1 - de Mink, Selma E. A1 - Gräfener, G. A1 - Crowther, Paul A1 - Vink, J. S. A1 - Almeida, Leonardo A. A1 - de Koter, A. A1 - Barbá, Rodolfo A1 - Herrero, A. A1 - Ulaczyk, Krzysztof T1 - The tarantula massive binary monitoring BT - II. First SB2 orbital and spectroscopic analysis for the Wolf-Rayet binary R145 JF - Astronomy and astrophysics : an international weekly journal N2 - We present the first SB2 orbital solution and disentanglement of the massive Wolf-Rayet binary R145 (P = 159 d) located in the Large Magellanic Cloud. The primary was claimed to have a stellar mass greater than 300 M-circle dot, making it a candidate for being the most massive star known to date. While the primary is a known late-type, H-rich Wolf-Rayet star (WN6h), the secondary has so far not been unambiguously detected. Using moderate-resolution spectra, we are able to derive accurate radial velocities for both components. By performing simultaneous orbital and polarimetric analyses, we derive the complete set of orbital parameters, including the inclination. The spectra are disentangled and spectroscopically analyzed, and an analysis of the wind-wind collision zone is conducted. The disentangled spectra and our models are consistent with a WN6h type for the primary and suggest that the secondary is an O3.5 If*/WN7 type star. We derive a high eccentricity of e = 0 : 78 and minimum masses of M-1 sin(3) i approximate to M-2 sin(3) i = 13 +/- 2 M-circle dot, with q = M-2/M-1 = 1.01 +/- 0.07. An analysis of emission excess stemming from a wind-wind collision yields an inclination similar to that obtained from polarimetry (i = 39 +/- 6 degrees). Our analysis thus implies M-1 = 53(-20)(+40) and M2 = 54(-20)(+40) M-circle dot, excluding M-1 > 300 M-circle dot. A detailed comparison with evolution tracks calculated for single and binary stars together with the high eccentricity suggests that the components of the system underwent quasi-homogeneous evolution and avoided mass-transfer. This scenario would suggest current masses of approximate to 80 M-circle dot and initial masses of M-i,M-1 approximate to 10(5) and M-i,M-2 approximate to 90 M-circle dot, consistent with the upper limits of our derived orbital masses, and would imply an age of approximate to 2.2 Myr. KW - binaries: spectroscopic KW - stars: Wolf-Rayet KW - stars: massive KW - Magellanic Clouds KW - stars: individual: R 145 KW - stars: atmospheres Y1 - 2017 U6 - https://doi.org/10.1051/0004-6361/201629621 SN - 1432-0746 VL - 598 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Cabral, Juliano Sarmento A1 - Valente, Luis A1 - Hartig, Florian T1 - Mechanistic simulation models in macroecology and biogeography BT - state-of-art and prospects JF - Ecography : pattern and diversity in ecology N2 - Macroecology and biogeography are concerned with understanding biodiversity patterns across space and time. In the past, the two disciplines have addressed this question mainly with correlative approaches, despite frequent calls for more mechanistic explanations. Recent advances in computational power, theoretical understanding, and statistical tools are, however, currently facilitating the development of more system-oriented, mechanistic models. We review these models, identify different model types and theoretical frameworks, compare their processes and properties, and summarize emergent findings. We show that ecological (physiology, demographics, dispersal, biotic interactions) and evolutionary processes, as well as environmental and human-induced drivers, are increasingly modelled mechanistically; and that new insights into biodiversity dynamics emerge from these models. Yet, substantial challenges still lie ahead for this young research field. Among these, we identify scaling, calibration, validation, and balancing complexity as pressing issues. Moreover, particular process combinations are still understudied, and so far models tend to be developed for specific applications. Future work should aim at developing more flexible and modular models that not only allow different ecological theories to be expressed and contrasted, but which are also built for tight integration with all macroecological data sources. Moving the field towards such a ‘systems macroecology’ will test and improve our understanding of the causal pathways through which eco-evolutionary processes create diversity patterns across spatial and temporal scales. Y1 - 2016 U6 - https://doi.org/10.1111/ecog.02480 SN - 0906-7590 SN - 1600-0587 VL - 40 IS - 2 SP - 267 EP - 280 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Abdalla, H. A1 - Abramowski, A. A1 - Aharonian, Felix A. A1 - Benkhali, F. Ait A1 - Akhperjanian, A. G. A1 - Andersson, T. A1 - Anguener, E. O. A1 - Arrieta, M. A1 - Aubert, P. A1 - Backes, M. A1 - Balzer, A. A1 - Barnard, M. A1 - Becherini, Y. A1 - Tjus, J. Becker A1 - Berge, D. A1 - Bernhard, S. A1 - Bernlorhr, K. A1 - Blackwell, R. A1 - Bottcher, M. A1 - Boisson, C. A1 - Bolmont, J. A1 - Bordas, Pol A1 - Bregeon, J. A1 - Brun, F. A1 - Brun, P. A1 - Bryan, M. A1 - Bulik, T. A1 - Capasso, M. A1 - Carr, J. A1 - Casanova, Sabrina A1 - Cerruti, M. A1 - Chakraborty, N. A1 - Chalme-Calvet, R. A1 - Chaves, R. C. G. A1 - Chen, A. A1 - Chevalier, J. A1 - Chretien, M. A1 - Colafrancesco, S. A1 - Cologna, G. A1 - Condon, B. A1 - Conrad, J. A1 - Cui, Y. A1 - Davids, I. D. A1 - Decock, J. A1 - Degrange, B. A1 - Deil, C. A1 - Devin, J. A1 - deWilt, P. A1 - Dirson, L. A1 - Djannati-Atai, A. A1 - Domainko, W. A1 - Donath, A. A1 - Dubus, G. A1 - Dutson, K. A1 - Dyks, J. A1 - Edwards, T. A1 - Egberts, Kathrin A1 - Eger, P. A1 - Ernenwein, J. -P. A1 - Eschbach, S. A1 - Farnier, C. A1 - Fegan, S. A1 - Fernandes, M. V. A1 - Fiasson, A. A1 - Fontaine, G. A1 - Foerster, A. A1 - Funk, S. A1 - Fuessling, M. A1 - Gabici, S. A1 - Gajdus, M. A1 - Gallant, Y. A. A1 - Garrigoux, T. A1 - Giavitto, G. A1 - Giebels, B. A1 - Glicenstein, J. F. A1 - Gottschall, D. A1 - Goyal, A. A1 - Grondin, M. -H. A1 - Hadasch, D. A1 - Hahn, J. A1 - Haupt, M. A1 - Hawkes, J. A1 - Heinzelmann, G. A1 - Henri, G. A1 - Hermann, G. A1 - Hervet, O. A1 - Hinton, J. A. A1 - Hofmann, W. A1 - Hoischen, Clemens A1 - Holler, M. A1 - Horns, D. A1 - Ivascenko, A. A1 - Jacholkowska, A. A1 - Jamrozy, M. A1 - Janiak, M. A1 - Jankowsky, D. A1 - Jankowsky, F. A1 - Jingo, M. A1 - Jogler, T. A1 - Jouvin, L. A1 - Jung-Richardt, I. A1 - Kastendieck, M. A. A1 - Katarzynski, K. A1 - Katz, U. A1 - Kerszberg, D. A1 - Khelifi, B. A1 - Er, M. Kie Ff A1 - King, J. A1 - Klepser, S. A1 - Klochkov, D. A1 - Kluzniak, W. A1 - Kolitzus, D. A1 - Komin, Nu. A1 - Kosack, K. A1 - Krakau, S. A1 - Kraus, M. A1 - Krayzel, F. A1 - Kruger, P. P. A1 - Laffon, H. A1 - Lamanna, G. A1 - Lau, J. A1 - Lees, J. -P. A1 - Lefaucheur, J. A1 - Lefranc, V. A1 - Lemiere, A. A1 - Lemoine-Goumard, M. A1 - Lenain, J. -P. A1 - Leser, E. A1 - Lohse, T. A1 - Lorentz, M. A1 - Liu, R. A1 - Lopez-Coto, R. A1 - Lypova, I. A1 - Marandon, V. A1 - Marcowith, Alexandre A1 - Mariaud, C. A1 - Marx, R. A1 - Maurin, G. A1 - Maxted, N. A1 - Mayer, M. A1 - Meintjes, P. J. A1 - Meyer, M. A1 - Mitchell, A. M. W. A1 - Moderski, R. A1 - Mohamed, M. A1 - Mohrmann, L. A1 - Mora, K. A1 - Moulin, Emmanuel A1 - Murach, T. A1 - de Naurois, M. A1 - Niederwanger, F. A1 - Niemiec, J. A1 - Oakes, L. A1 - Odaka, H. A1 - Oettl, S. A1 - Ohm, S. A1 - Ostrowski, M. A1 - Oya, I. A1 - Padovani, M. A1 - Panter, M. A1 - Parsons, R. D. A1 - Pekeur, N. W. A1 - Pelletier, G. A1 - Perennes, C. A1 - Petrucci, P. -O. A1 - Peyaud, B. A1 - Piel, Q. A1 - Pita, S. A1 - Poon, H. A1 - Prokhorov, D. A1 - Prokoph, H. A1 - Puehlhofer, G. A1 - Punch, M. A1 - Quirrenbach, A. A1 - Raab, S. A1 - Reimer, A. A1 - Reimer, O. A1 - Renaud, M. A1 - de los Reyes, R. A1 - Rieger, F. A1 - Romoli, C. A1 - Rosier-Lees, S. A1 - Rowell, G. A1 - Rudak, B. A1 - Rulten, C. B. A1 - Sahakian, V. A1 - Salek, D. A1 - Sanchez, D. A. A1 - Santangelo, Andrea A1 - Sasaki, M. A1 - Schlickeiser, R. A1 - Schussler, F. A1 - Schulz, A. A1 - Schwanke, U. A1 - Schwemmer, S. A1 - Settimo, M. A1 - Seyffert, A. S. A1 - Shafi, N. A1 - Shilon, I. A1 - Simoni, R. A1 - Sol, H. A1 - Spanier, F. A1 - Spengler, G. A1 - Spies, F. A1 - Ert, Ff A1 - Stawarz, L. A1 - Steenkamp, R. A1 - Stegmann, Christian Michael A1 - Stinzing, F. A1 - Stycz, K. A1 - Sushch, I. A1 - Tavernet, J. -P. A1 - Tavernier, T. A1 - Taylor, A. M. A1 - Terrier, R. A1 - Tibaldo, L. A1 - Tiziani, D. A1 - Tluczykont, M. A1 - Trichard, C. A1 - Tuffs, R. A1 - Uchiyama, Y. A1 - van der Walt, D. J. A1 - van Eldik, C. A1 - van Rensburg, C. A1 - van Soelen, B. A1 - Vasileiadis, G. A1 - Veh, J. A1 - Venter, C. A1 - Viana, A. A1 - Vincent, P. A1 - Vink, J. A1 - Voisin, F. A1 - Voelk, H. J. A1 - Vuillaume, T. A1 - Wadiasingh, Z. A1 - Wagner, S. J. A1 - Wagner, P. A1 - Wagner, R. M. A1 - White, R. A1 - Wierzcholska, A. A1 - Willmann, P. A1 - Woernlein, A. A1 - Wouters, D. A1 - Yang, R. A1 - Zabalza, V. A1 - Zaborov, D. A1 - Zacharias, M. A1 - Zdziarski, A. A. A1 - Zech, Alraune A1 - Zefi, F. A1 - Ziegler, A. A1 - Zywucka, N. T1 - Characterizing the gamma-ray long-term variability of PKS2155 304 with HESS and Fermi-LAT JF - Astronomy and astrophysics : an international weekly journal N2 - Studying the temporal variability of BL Lac objects at the highest energies provides unique insights into the extreme physical processes occurring in relativistic jets and in the vicinity of super-massive black holes. To this end, the long-term variability of the BL Lac object PKS 2155 304 is analyzed in the high (HE, 100MeV < E < 300 GeV) and very high energy (VHE, E > 200 GeV) gamma-ray domain. Over the course of similar to 9 yr of H. E. S. S. observations the VHE light curve in the quiescent state is consistent with a log-normal behavior. The VHE variability in this state is well described by flicker noise (power-spectral-density index beta(VHE) = 1 .10(+ 0 : 10) (0 : 13)) on timescales larger than one day. An analysis of similar to 5.5 yr of HE Fermi-LAT data gives consistent results (beta(HE) = 1 : 20(+ 0 : 21) (0 : 23), on timescales larger than 10 days) compatible with the VHE findings. The HE and VHE power spectral densities show a scale invariance across the probed time ranges. A direct linear correlation between the VHE and HE fluxes could neither be excluded nor firmly established. These long-term-variability properties are discussed and compared to the red noise behavior (beta similar to 2) seen on shorter timescales during VHE-flaring states. The difference in power spectral noise behavior at VHE energies during quiescent and flaring states provides evidence that these states are influenced by different physical processes, while the compatibility of the HE and VHE long-term results is suggestive of a common physical link as it might be introduced by an underlying jet-disk connection. KW - galaxies: active KW - BL Lacertae objects: individual: PKS 2155-304 KW - gamma rays: galaxies KW - galaxies: jets KW - galaxies: nuclei KW - radiation mechanisms: non-thermal Y1 - 2017 U6 - https://doi.org/10.1051/0004-6361/201629419 SN - 1432-0746 SN - 0004-6361 VL - 598 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Beijersbergen, Chantal M. I. A1 - Granacher, Urs A1 - Gaebler, Martijn A1 - DeVita, Paul A1 - Hortobagyi, Tibor T1 - Hip mechanics underlie lower extremity power training-induced increase in old adults’ fast gait velocity BT - the Potsdam Gait Study (POGS) JF - Gait & posture N2 - Methods: As part of the Potsdam Gait Study (POGS), healthy old adults completed a no-intervention control period (69.1 +/- 4A yrs, n =14) or a power training program followed by detraining (72.9 +/- 5.4 yrs, n = 15).We measured isokinetic knee extensor and plantarflexor power and measured hip, knee and ankle kinetics at habitual, fast and standardized walking speeds. Results: Power training significantly increased isokinetic knee extensor power (25%), plantarflexor power (43%), and fast gait velocity (5.9%). Gait mechanics underlying the improved fast gait velocity included increases in hip angular impulse (29%) and H1 work (37%) and no changes in positive knee (K2) and A2 work. Detraining further improved fast gait velocity (4.7%) with reductions in H1(-35%), and increases in K2 (36%) and A2 (7%). Conclusion: Power training increased fast gait velocity in healthy old adults by increasing the reliance on hip muscle function and thus further strengthened the age-related distal-to-proximal shift in muscle function. (C) 2016 Elsevier B.V. All rights reserved. KW - Walking KW - Biomechanics KW - Detraining KW - Muscle KW - Exercise Y1 - 2017 U6 - https://doi.org/10.1016/j.gaitpost.2016.12.024 SN - 0966-6362 SN - 1879-2219 VL - 52 SP - 338 EP - 344 PB - Elsevier CY - Clare ER - TY - JOUR A1 - Bergholz, Kolja A1 - May, Felix A1 - Giladi, Itamar A1 - Ristow, Michael A1 - Ziv, Yaron A1 - Jeltsch, Florian T1 - Environmental heterogeneity drives fine-scale species assembly and functional diversity of annual plants in a semi-arid environment JF - Perspectives in plant ecology, evolution and systematics N2 - Spatial environmental heterogeneity is considered a fundamental factor for the maintenance of plant species richness. However, it still remains unclear whether heterogeneity may also facilitate coexistence at fine grain sizes or whether other processes, like mass effects and source sink dynamics due to dispersal, control species composition and diversity at these scales. In this study, we used two complimentary analyses to identify the role of heterogeneity within 15 m x 15 m plots for the coexistence of species-rich annual communities in a semi-arid environment along a steep precipitation gradient. Specifically, we: (a) analyzed the effect of environmental heterogeneity on species, functional and phylogenetic diversity within microsites (alpha diversity, 0.06 m(2) and 1 m(2)), across microsites (beta diversity), and diversity at the entire plot (gamma diversity); (b) further we used two null models to detect non-random trait and phylogenetic patterns in order to infer assembly processes, i.e. whether co-occurring species tend to share similar traits (trait convergence) or dissimilar traits (trait divergence). In general, our results showed that heterogeneity had a positive effect on community diversity. Specifically, for alpha diversity, the effect was significant for functional diversity, and not significant for either species or phylogenetic diversities. For beta diversity, all three measures of community diversity (species, functional, and phylogenetic) increased significantly, as they also did for gamma diversity, where functional measures were again stronger than for species or phylogenetic measures. In addition, the null model approach consistently detected trait convergence, indicating that species with similar traits tended to co-occur and had high abundances in a given microsite. While null model analysis across the phylogeny partly supported these trait findings, showing phylogenetic underdispersion at the 1m(2) grain size, surprisingly when species abundances in microsites were analyzed they were more evenly distributed across the phylogenetic tress than expected (phylogenetic overdispersion). In conclusion, our results provide compelling support that environmental heterogeneity at a relatively fine scale is an important factor for species co-existence as it positively affects diversity as well as influences species assembly. Our study underlines the need for trait-based approaches conducted at fine grain sizes in order to better understand species coexistence and community assembly. (C) 2017 Elsevier GmbH. All rights reserved. KW - Community assembly KW - Plant functional trait KW - Habitat heterogeneity KW - Limiting similarity KW - Environmental filtering KW - Heterogeneity species diversity relationship Y1 - 2017 U6 - https://doi.org/10.1016/j.ppees.2017.01.001 SN - 1433-8319 VL - 24 SP - 138 EP - 146 PB - Elsevier CY - Jena ER - TY - GEN A1 - Grisic, Ana-Marija A1 - Huisinga, Wilhelm A1 - Reinisch, W. A1 - Kloft, Charlotte T1 - P485 Dosing infliximab in Crohn's disease BT - is adjustment for body size justified? T2 - Journal of Crohn's and Colitis N2 - Background: Infliximab (IFX), an anti-TNF monoclonal antibody approved for the treatment of inflammatory bowel disease, is dosed per kg body weight (BW). However, the rationale for body size adjustment has not been unequivocally demonstrated [1], and first attempts to improve IFX therapy have been undertaken [2]. The aim of our study was to assess the impact of different dosing strategies (i.e. body size-adjusted and fixed dosing) on drug exposure and pharmacokinetic (PK) target attainment. For this purpose, a comprehensive simulation study was performed, using patient characteristics (n=116) from an in-house clinical database. Methods: IFX concentration-time profiles of 1000 virtual, clinically representative patients were generated using a previously published PK model for IFX in patients with Crohn's disease [3]. For each patient 1000 profiles accounting for PK variability were considered. The IFX exposure during maintenance treatment after the following dosing strategies was compared: i) fixed dose, and per ii) BW, iii) lean BW (LBW), iv) body surface area (BSA), v) height (HT), vi) body mass index (BMI) and vii) fat-free mass (FFM)). For each dosing strategy the variability in maximum concentration Cmax, minimum concentration Cmin (= C8weeks) and area under the concentration-time curve (AUC), as well as percent of patients achieving the PK target, Cmin=3 μg/mL [4] were assessed. Results: For all dosing strategies the variability of Cmin (CV ≈110%) was highest, compared to Cmax and AUC, and was of similar extent regardless of dosing strategy. The proportion of patients reaching the PK target (≈⅓ was approximately equal for all dosing strategies. Y1 - 2017 U6 - https://doi.org/10.1093/ecco-jcc/jjx002.609 SN - 1873-9946 SN - 1876-4479 VL - 11 IS - 1 SP - S325 EP - S326 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Archambault, S. A1 - Archer, A. A1 - Benbow, W. A1 - Buchovecky, M. A1 - Bugaev, V. A1 - Cerruti, M. A1 - Connolly, M. P. A1 - Cui, W. A1 - Falcone, A. A1 - Alonso, M. Fernandez A1 - Finley, J. P. A1 - Fleischhack, H. A1 - Fortson, L. A1 - Furniss, A. A1 - Griffin, S. A1 - Hutten, M. A1 - Hervet, O. A1 - Holder, J. A1 - Humensky, T. B. A1 - Johnson, C. A. A1 - Kaaret, P. A1 - Kar, P. A1 - Kieda, D. A1 - Krause, M. A1 - Krennrich, F. A1 - Lang, M. J. A1 - Lin, T. T. Y. A1 - Maier, G. A1 - McArthur, S. A1 - Moriarty, P. A1 - Nieto, D. A1 - Ong, R. A. A1 - Otte, A. N. A1 - Pohl, M. A1 - Popkow, A. A1 - Pueschel, Elisa A1 - Quinn, J. A1 - Ragan, K. A1 - Reynolds, P. T. A1 - Richards, G. T. A1 - Roache, E. A1 - Rovero, A. C. A1 - Sadeh, I. A1 - Shahinyan, K. A1 - Staszak, D. A1 - Telezhinsky, Igor O. A1 - Tyler, J. A1 - Wakely, S. P. A1 - Weinstein, A. A1 - Weisgarber, T. A1 - Wilcox, P. A1 - Wilhelm, Alina A1 - Williams, D. A. A1 - Zitzer, B. T1 - Search for Magnetically Broadened Cascade Emission from Blazars with VERITAS JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - We present a search for magnetically broadened gamma-ray emission around active galactic nuclei (AGNs), using VERITAS observations of seven hard-spectrum blazars. A cascade process occurs when multi-TeV gamma-rays from an AGN interact with extragalactic background light (EBL) photons to produce electron-positron pairs, which then interact with cosmic microwave background photons via inverse-Compton scattering to produce gamma-rays. Due to the deflection of the electron- positron pairs, a non-zero intergalactic magnetic field (IGMF) would potentially produce detectable effects on the angular distribution of the cascade emission. In particular, an angular broadening compared to the unscattered emission could occur. Through non-detection of angularly broadened emission from 1ES 1218 vertical bar 304, the source with the largest predicted cascade fraction, we exclude a range of IGMF strengths around 10(-14) G at the 95% confidence level. The extent of the exclusion range varies with the assumptions made about the intrinsic spectrum of 1ES. 1218+304 and the EBL model used in the simulation of the cascade process. All of the sources are used to set limits on the flux due to extended emission. KW - BL Lacertae objects: general KW - galaxies: active KW - gamma rays: galaxies KW - magnetic fields Y1 - 2017 U6 - https://doi.org/10.3847/1538-4357/835/2/288 SN - 0004-637X SN - 1538-4357 VL - 835 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Warren, Donald C. A1 - Ellison, Donald C. A1 - Barkov, Maxim V. A1 - Nagataki, Shigehiro T1 - Nonlinear Particle Acceleration and Thermal Particles in GRB Afterglows JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - The standard model for GRB afterglow emission treats the accelerated electron population as a simple power law, N(E) proportional to E-p for p greater than or similar to 2. However, in standard Fermi shock acceleration, a substantial fraction of the swept-up particles do not enter the acceleration process at all. Additionally, if acceleration is efficient, then the nonlinear back-reaction of accelerated particles on the shock structure modifies the shape of the nonthermal tail of the particle spectra. Both of these modifications to the standard synchrotron afterglow impact the luminosity, spectra, and temporal variation of the afterglow. To examine the effects of including thermal particles and nonlinear particle acceleration on afterglow emission, we follow a hydrodynamical model for an afterglow jet and simulate acceleration at numerous points during the evolution. When thermal particles are included, we find that the electron population is at no time well fitted by a single power law, though the highest-energy electrons are; if the acceleration is efficient, then the power-law region is even smaller. Our model predicts hard-soft-hard spectral evolution at X-ray energies, as well as an uncoupled X-ray and optical light curve. Additionally, we show that including emission from thermal particles has drastic effects (increases by factors of 100 and 30, respectively) on the observed flux at optical and GeV energies. This enhancement of GeV emission makes afterglow detections by future gamma-ray observatories, such as CTA, very likely. KW - acceleration of particles KW - cosmic rays KW - gamma-ray burst: general KW - shock waves KW - turbulence Y1 - 2017 U6 - https://doi.org/10.3847/1538-4357/aa56c3 SN - 0004-637X SN - 1538-4357 VL - 835 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Postnov, K. A1 - Oskinova, Lidia M. A1 - Torrejon, J. M. T1 - A propelling neutron star in the enigmatic Be-star gamma Cassiopeia JF - Monthly notices of the Royal Astronomical Society N2 - gamma Cassiopeia (gamma Cas), is known to be a binary system consisting of a Be-type star and a low-mass (M similar to 1M(circle dot)) companion of unknown nature orbiting in the Be-disc plane. Here, we apply the quasi-spherical accretion theory on to a compact magnetized star and show that if the low-mass companion of gamma Cas is a fast spinning neutron star, the key observational signatures of. Cas are remarkably well reproduced. Direct accretion on to this fast rotating neutron star is impeded by the propeller mechanism. In this case, around the neutron star magnetosphere a hot shell is formed which emits thermal X-rays in qualitative and quantitative agreement with observed properties of the X-ray emission from gamma Cas. We suggest that gamma Cas and its analogues constitute a new subclass of Be-type X-ray binaries hosting rapidly rotating neutron stars formed in supernova explosions with small kicks. The subsequent evolutionary stage of gamma Cas and its analogues should be the X Per-type binaries comprising low-luminosity slowly rotating X-ray pulsars. The model explains the enigmatic X-ray emission from gamma Cas, and also establishes evolutionary connections between various types of rotating magnetized neutron stars in Be-binaries. KW - stars: emission-line, Be KW - stars: neutron Y1 - 2017 U6 - https://doi.org/10.1093/mnrasl/slw223 SN - 0035-8711 SN - 1365-2966 VL - 465 IS - 1 SP - L119 EP - L123 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Valente, Luis A1 - Etienne, Rampal S. A1 - Davalos, Liliana M. T1 - Recent extinctions disturb path to equilibrium diversity in Caribbean bats JF - Nature Ecology & Evolution N2 - Islands are ideal systems to model temporal changes in biodiversity and reveal the influence of humans on natural communities. Although theory predicts biodiversity on islands tends towards an equilibrium value, the recent extinction of large proportions of island biotas complicates testing this model. The well-preserved subfossil record of Caribbean bats-involving multiple insular radiations-provides a rare opportunity to model diversity dynamics in an insular community. Here, we reconstruct the diversity trajectory in noctilionoid bats of the Greater Antilles by applying a dynamic model of colonization, extinction and speciation to phylogenetic and palaeontological data including all known extinct and extant species. We show species richness asymptotes to an equilibrium value, a demonstration of natural equilibrium dynamics across an entire community. However, recent extinctions-many caused by humans-have wiped out nearly a third of island lineages, dragging diversity away from equilibrium. Using a metric to measure island biodiversity loss, we estimate it will take at least eight million years to regain pre-human diversity levels. Our integrative approach reveals how anthropogenic extinctions can drastically alter the natural trajectory of biological communities, resulting in evolutionary disequilibrium. Y1 - 2017 U6 - https://doi.org/10.1038/s41559-016-0026 SN - 2397-334X VL - 1 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Kelly, Mary Allison A1 - Roland, Steffen A1 - Zhang, Qianqian A1 - Lee, Youngmin A1 - Kabius, Bernd A1 - Wang, Qing A1 - Gomez, Enrique D. A1 - Neher, Dieter A1 - You, Wei T1 - Incorporating Fluorine Substitution into Conjugated Polymers for Solar Cells BT - three Different Means, Same Results JF - The journal of physical chemistry : C, Nanomaterials and interfaces N2 - Fluorinating conjugated polymers is a proven strategy for creating high performance materials in polymer solar cells, yet few studies have investigated the importance of the fluorination method. We compare the performance of three fluorinated systems: a poly(benzodithieno-dithienyltriazole) (PBnDT-XTAZ) random copolymer where 50% of the acceptor units are difluorinated, PBnDT-mFTAZ where every acceptor unit is monofluorinated, and a 1:1 physical blend of the difluorinated and nonfluorinated polymer. All systems have the same degree of fluorination (50%) yet via different methods (chemically vs physically, random vs regular). We show that these three systems have equivalent photovoltaic behavior:,similar to 5.2% efficiency with a short-circuit current (J(sc)) at,similar to 11 mA cm(-2), an open-circuit voltage (v(oc)) at 0.77 V, and a fill factor (FF) of similar to 60%. Further investigation of these three systems demonstrates that the charge generation, charge extraction, and charge transfer state are essentially identical for the three studied systems. Transmission electron microscopy shows no significant differences in the morphologies. All these data illustrate that it is possible to improve performance not only via regular or random fluorination but also by physical addition via a ternary blend. Thus, our results demonstrate the versatility of incorporating fluorine in the active layer of polymer solar cells to enhance device performance. Y1 - 2017 U6 - https://doi.org/10.1021/acs.jpcc.6b10993 SN - 1932-7447 VL - 121 IS - 4 SP - 2059 EP - 2068 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Schmidt, Bernd A1 - Audörsch, Stephan T1 - Stereoselective Total Syntheses of Polyacetylene Plant Metabolites via Ester-Tethered Ring Closing Metathesis JF - The journal of organic chemistry N2 - Total syntheses of five naturally occurring polyacetylenes from three different plants are described. These natural products have in common an E,Z-configured conjugated diene linked to a di-or triyne chain. As the key method to stereoselectively establish the E,Z-diene part, an ester-tethered ring-closing metathesis/base-induced eliminative ring opening sequence was used. The results presented herein do not only showcase the utility of this tethered RCM variant but have also prompted us to suggest that the originally assigned absolute configurations of chiral polyacetylenes from Atractylodes macrocephala should be revised or at least reconsidered. Y1 - 2017 U6 - https://doi.org/10.1021/acs.joc.6b02987 SN - 0022-3263 VL - 82 IS - 3 SP - 1743 EP - 1760 PB - American Chemical Society CY - Washington ER - TY - GEN A1 - Metzler, Ralf T1 - Anomalous Diffusion in Membranes and the Cytoplasm of Biological Cells T2 - Biophysical journal Y1 - 2017 U6 - https://doi.org/10.1016/j.bpj.2016.11.2577 SN - 0006-3495 SN - 1542-0086 VL - 112 IS - 3 SP - 476A EP - 476A PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Gianelli, Claudia A1 - Marzocchi, Michele A1 - Borghi, Anna M. T1 - Grasping the Agent’s Perspective BT - a Kinematics Investigation of Linguistic Perspective in Italian and German JF - Frontiers in psychology KW - perspective taking KW - action KW - language comprehension KW - motor chains KW - motor system KW - motor resonance KW - pronouns KW - action verbs Y1 - 0107 U6 - https://doi.org/10.3389/fpsyg.2017.00042 SN - 1664-1078 VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - GEN A1 - Metzler, Ralf T1 - Gaussianity Fair BT - the Riddle of Anomalous yet Non-Gaussian Diffusion T2 - Biophysical journal Y1 - 2017 U6 - https://doi.org/10.1016/j.bpj.2016.12.019 SN - 0006-3495 SN - 1542-0086 VL - 112 IS - 3 SP - 413 EP - 415 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Zimmermann, Heike Hildegard A1 - Raschke, Elena A1 - Epp, Laura Saskia A1 - Stoof-Leichsenring, Kathleen Rosemarie A1 - Schwamborn, Georg A1 - Schirrmeister, Lutz A1 - Overduin, Pier Paul A1 - Herzschuh, Ulrike T1 - Sedimentary ancient DNA and pollen reveal the composition of plant organic matter in Late Quaternary permafrost sediments of the Buor Khaya Peninsula (north-eastern Siberia) JF - Biogeosciences N2 - Organic matter deposited in ancient, ice-rich permafrost sediments is vulnerable to climate change and may contribute to the future release of greenhouse gases; it is thus important to get a better characterization of the plant organic matter within such sediments. From a Late Quaternary permafrost sediment core from the Buor Khaya Peninsula, we analysed plant-derived sedimentary ancient DNA (sedaDNA) to identify the taxonomic composition of plant organic matter, and undertook palynological analysis to assess the environmental conditions during deposition. Using sedaDNA, we identified 154 taxa and from pollen and non-pollen palynomorphs we identified 83 taxa. In the deposits dated between 54 and 51 kyr BP, sedaDNA records a diverse low-centred polygon plant community including recurring aquatic pond vegetation while from the pollen record we infer terrestrial open-land vegetation with relatively dry environmental conditions at a regional scale. A fluctuating dominance of either terrestrial or swamp and aquatic taxa in both proxies allowed the local hydrological development of the polygon to be traced. In deposits dated between 11.4 and 9.7 kyr BP (13.4-11.1 cal kyr BP), sedaDNA shows a taxonomic turnover to moist shrub tundra and a lower taxonomic richness compared to the older samples. Pollen also records a shrub tundra community, mostly seen as changes in relative proportions of the most dominant taxa, while a decrease in taxonomic richness was less pronounced compared to sedaDNA. Our results show the advantages of using sedaDNA in combination with palynological analyses when macrofossils are rarely preserved. The high resolution of the sedaDNA record provides a detailed picture of the taxonomic composition of plant-derived organic matter throughout the core, and palynological analyses prove valuable by allowing for inferences of regional environmental conditions. Y1 - 2017 U6 - https://doi.org/10.5194/bg-14-575-2017 SN - 1726-4170 SN - 1726-4189 VL - 14 IS - 3 SP - 575 EP - 596 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Schweighöfer, F. A1 - Moreno, J. A1 - Bobone, Sara A1 - Chiantia, Salvatore A1 - Herrmann, A. A1 - Hecht, S. A1 - Wachtveitl, Josef T1 - Connectivity pattern modifies excited state relaxation dynamics of fluorophore-photoswitch molecular dyads JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - In order to modulate the emission of BODIPY fluorophores, they were connected to a diarylethene (DAE) photoswitch via phenylene-ethynylene linkers of different lengths and orientations. The latter allowed for modulation of the electronic coupling in the prepared four BODIPY-DAE dyads, which were compared also to appropriate BODIPY and DAE model compounds by steady state as well as time-resolved spectroscopies. In their open isomers, all dyads show comparable luminescence behavior indicative of an unperturbed BODIPY fluorophore. In strong contrast, in the closed isomers the BODIPY emission is efficiently quenched but the deactivation mechanism depends on the nature of the linker. The most promising dyad was rendered water-soluble by means of micellar encapsulation and aqueous suspensions were investigated by fluorescence spectroscopy and microscopy. Our results (i) illustrate that the electronic communication between the BODIPY and DAE units can indeed be fine-tuned by the nature of the linker to achieve fluorescence modulation while maintaining photoswitchability and (ii) highlight potential applications to image and control biological processes with high spatio-temporal resolution. Y1 - 2016 U6 - https://doi.org/10.1039/c6cp07112k SN - 1463-9076 SN - 1463-9084 VL - 19 SP - 4010 EP - 4018 PB - Royal Society of Chemistry CY - Cambridge ER - TY - GEN A1 - Felser, Claudia A1 - Phillips, Colin A1 - Wagers, Matthew T1 - Editorial: Encoding and Navigating Linguistic Representations in Memory T2 - Frontiers in psychology KW - sentence comprehension KW - encoding KW - memory retrieval KW - interference KW - anaphor resolution KW - agreement processing KW - filler-gap dependencies Y1 - 2017 U6 - https://doi.org/10.3389/fpsyg.2017.00164 SN - 1664-1078 VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Dallmeyer, Anne A1 - Claussen, Martin A1 - Ni, Jian A1 - Cao, Xianyong A1 - Wang, Yongbo A1 - Fischer, Nils A1 - Pfeiffer, Madlene A1 - Jin, Liya A1 - Khon, Vyacheslav A1 - Wagner, Sebastian A1 - Haberkorn, Kerstin A1 - Herzschuh, Ulrike T1 - Biome changes in Asia since the mid-Holocene BT - an analysis of different transient Earth system model simulations JF - Climate of the past : an interactive open access journal of the European Geosciences Union N2 - The large variety of atmospheric circulation systems affecting the eastern Asian climate is reflected by the complex Asian vegetation distribution. Particularly in the transition zones of these circulation systems, vegetation is supposed to be very sensitive to climate change. Since proxy records are scarce, hitherto a mechanistic understanding of the past spatio-temporal climate-vegetation relationship is lacking. To assess the Holocene vegetation change and to obtain an ensemble of potential mid-Holocene biome distributions for eastern Asia, we forced the diagnostic biome model BIOME4 with climate anomalies of different transient Holocene climate simulations performed in coupled atmosphere-ocean(-vegetation) models. The simulated biome changes are compared with pollen-based biome records for different key regions. In all simulations, substantial biome shifts during the last 6000 years are confined to the high northern latitudes and the monsoon-westerly wind transition zone, but the temporal evolution and amplitude of change strongly depend on the climate forcing. Large parts of the southern tundra are replaced by taiga during the mid-Holocene due to a warmer growing season and the boreal treeline in northern Asia is shifted northward by approx. 4 degrees in the ensemble mean, ranging from 1.5 to 6 degrees in the individual simulations, respectively. This simulated treeline shift is in agreement with pollen-based reconstructions from northern Siberia. The desert fraction in the transition zone is reduced by 21% during the mid-Holocene compared to pre-industrial due to enhanced precipitation. The desert-steppe margin is shifted westward by 5 degrees (1-9 degrees in the individual simulations). The forest biomes are expanded north-westward by 2 degrees, ranging from 0 to 4 degrees in the single simulations. These results corroborate pollen-based reconstructions indicating an extended forest area in north-central China during the mid-Holocene. According to the model, the forest-to-non-forest and steppe-to-desert changes in the climate transition zones are spatially not uniform and not linear since the mid-Holocene. Y1 - 2017 U6 - https://doi.org/10.5194/cp-13-107-2017 SN - 1814-9324 SN - 1814-9332 VL - 13 IS - 2 SP - 107 EP - 134 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Molnos, Sonja A1 - Mamdouh, Tarek A1 - Petri, Stefan A1 - Nocke, Thomas A1 - Weinkauf, Tino A1 - Coumou, Dim T1 - A network-based detection scheme for the jet stream core JF - Earth system dynamics N2 - The polar and subtropical jet streams are strong upper-level winds with a crucial influence on weather throughout the Northern Hemisphere midlatitudes. In particular, the polar jet is located between cold arctic air to the north and warmer subtropical air to the south. Strongly meandering states therefore often lead to extreme surface weather. The parameter values of the detection scheme are optimized using simulated annealing and a skill function that accounts for the zonal-mean jet stream position (Rikus, 2015). After the successful optimization process, we apply our scheme to reanalysis data covering 1979-2015 and calculate seasonal-mean probabilistic maps and trends in wind strength and position of jet streams. We present longitudinally defined probability distributions of the positions for both jets for all on the Northern Hemisphere seasons. This shows that winter is characterized by two well-separated jets over Europe and Asia (ca. 20 degrees W to 140 degrees E). In contrast, summer normally has a single merged jet over the western hemisphere but can have both merged and separated jet states in the eastern hemisphere. Y1 - 2017 U6 - https://doi.org/10.5194/esd-8-75-2017 SN - 2190-4979 SN - 2190-4987 VL - 8 IS - 1 SP - 75 EP - 89 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Archambault, S. A1 - Archer, A. A1 - Benbow, Wystan A1 - Bird, Ralph A1 - Bourbeau, E. A1 - Buchovecky, M. A1 - Buckley, J. H. A1 - Bugaev, V. A1 - Cerruti, M. A1 - Connolly, M. P. A1 - Cui, W. A1 - Dwarkadas, Vikram V. A1 - Errando, M. A1 - Falcone, A. A1 - Feng, Q. A1 - Finley, J. P. A1 - Fleischhack, H. A1 - Fortson, L. A1 - Furniss, A. A1 - Griffin, S. A1 - Huetten, M. A1 - Hanna, D. A1 - Holder, J. A1 - Johnson, C. A. A1 - Kaaret, P. A1 - Kar, P. A1 - Kelley-Hoskins, N. A1 - Kertzman, M. A1 - Kieda, D. A1 - Krause, M. A1 - Kumar, S. A1 - Lang, M. J. A1 - Maier, G. A1 - McArthur, S. A1 - McCann, A. A1 - Moriarty, P. A1 - Mukherjee, R. A1 - Nieto, D. A1 - Ong, R. A. A1 - Otte, A. N. A1 - Park, Nahee A1 - Pohl, Martin A1 - Popkow, A. A1 - Pueschel, Elisa A1 - Quinn, J. A1 - Ragan, K. A1 - Reynolds, P. T. A1 - Richards, G. T. A1 - Roache, E. A1 - Sadeh, I. A1 - Santander, M. A1 - Sembroski, G. H. A1 - Shahinyan, K. A1 - Slane, P. A1 - Staszak, D. A1 - Telezhinsky, Igor O. A1 - Trepanier, S. A1 - Tyler, J. A1 - Wakely, S. P. A1 - Weinstein, A. A1 - Weisgarber, T. A1 - Wilcox, P. A1 - Wilhelm, Alina A1 - Williams, D. A. A1 - Zitzer, B. T1 - Gamma-ray Observations of Tycho's Supernova Remnant with VERITAS and Fermi JF - The astrophysical journal : an international review of spectroscopy and astronomical physics KW - material KW - data behind figure Y1 - 2017 U6 - https://doi.org/10.3847/1538-4357/836/1/23 SN - 0004-637X SN - 1538-4357 VL - 836 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Judah, Gaby A1 - De Witt Huberts, Jessie A1 - Drassal, Allan A1 - Aunger, Robert T1 - The development and validation of a Real Time Location System to reliably monitor everyday activities in natural contexts JF - PLoS one N2 - Introduction Methods A commercial Real Time Location System was adapted to meet these requirements and subsequently validated in three households by monitoring various bathroom behaviours. Results The results indicate that the system is robust, can monitor behaviours over the long-term in different households and can reliably distinguish between individuals. Precision rates were high and consistent. Recall rates were less consistent across households and behaviours, although recall rates improved considerably with practice at set-up of the system. The achieved precision and recall rates were comparable to the rates observed in more controlled environments using more valid methods of ground truthing. Conclusion These initial findings indicate that the system is a valuable, flexible and robust system for monitoring behaviour in its natural environment that would allow new research questions to be addressed. Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0171610 SN - 1932-6203 VL - 12 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Garakani, Tayebeh Mirzaei A1 - Richter, Marina Juliane A1 - Böker, Alexander T1 - Controlling the bio-inspired synthesis of silica JF - Journal of colloid and interface science N2 - The influence of different parameters on the silicification procedure using lysozyme is reported. When polyethoxysiloxane (PEOS), an internally crosslinked silica reservoir, is used, regular structures with a narrow size distribution could be obtained only via introducing the silica precursor in two steps including initial dropping and subsequent addition of residual oil phase in one portion. We found that mixing sequence of mineralizing agents in the presence of a positively charged surfactant plays a key role in terms of silica precipitation when tetraethoxyorthosilicate (TEOS) is the oil phase. In contrast, well mineralized crumpled features with high specific surface area could be synthesized in the presence of PEOS as a silica precursor polymer, regardless of mixing sequence. Moreover, introducing sodium dodecyl sulfate (SDS) as a negatively charged surfactant resulted in regular silica sphere formation only in combination with hexylene glycol (MPD) as a specific co-solvent. Finally, it is demonstrated that by inclusion of different nanoparticles even more sophisticated hybrid materials can be generated. KW - Silicification KW - Lysozyme KW - Polyetlioxysiloxane KW - High specific surface area KW - Surfactant KW - Nanoparticles KW - Hybrid materials Y1 - 2016 U6 - https://doi.org/10.1016/j.jcis.2016.10.069 SN - 0021-9797 SN - 1095-7103 VL - 488 SP - 322 EP - 334 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Guo, Li A1 - Paycha, Sylvie A1 - Zhang, Bin T1 - Algebraic Birkhoff factorization and the Euler–Maclaurin formula on cones JF - Duke mathematical journal N2 - We equip the space of lattice cones with a coproduct which makes it a cograded, coaugmented, connnected coalgebra. The exponential generating sum and exponential generating integral on lattice cones can be viewed as linear maps on this space with values in the space of meromorphic germs with linear poles at zero. We investigate the subdivision properties-reminiscent of the inclusion-exclusion principle for the cardinal on finite sets-of such linear maps and show that these properties are compatible with the convolution quotient of maps on the coalgebra. Implementing the algebraic Birkhoff factorization procedure on the linear maps under consideration, we factorize the exponential generating sum as a convolution quotient of two maps, with each of the maps in the factorization satisfying a subdivision property. A direct computation shows that the polar decomposition of the exponential generating sum on a smooth lattice cone yields an Euler-Maclaurin formula. The compatibility with subdivisions of the convolution quotient arising in the algebraic Birkhoff factorization then yields the Euler-Maclaurin formula for any lattice cone. This provides a simple formula for the interpolating factor by means of a projection formula. Y1 - 2017 U6 - https://doi.org/10.1215/00127094-3715303 SN - 0012-7094 SN - 1547-7398 VL - 166 IS - 3 SP - 537 EP - 571 PB - Duke Univ. Press CY - Durham ER - TY - JOUR A1 - Taylor, Vivien A1 - Goodale, Britton A1 - Raab, Andrea A1 - Schwerdtle, Tanja A1 - Reimer, Ken A1 - Conklin, Sean A1 - Karagas, Margaret R. A1 - Francesconi, Kevin A. T1 - Human exposure to organic arsenic species from seafood JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man N2 - Seafood, including finfish, shellfish, and seaweed, is the largest contributor to arsenic (As) exposure in many human populations. In contrast to the predominance of inorganic As in water and many terrestrial foods, As in marine-derived foods is present primarily in the form of organic compounds. To date, human exposure and toxicological assessments have focused on inorganic As, while organic As has generally been considered to be nontoxic. However, the high concentrations of organic As in seafood, as well as the often complex As speciation, can lead to complications in assessing As exposure from diet. In this report, we evaluate the presence and distribution of organic As species in seafood, and combined with consumption data, address the current capabilities and needs for determining human exposure to these compounds. The analytical approaches and shortcomings for assessing these compounds are reviewed, with a focus on the best practices for characterization and quantitation. Metabolic pathways and toxicology of two important classes of organic arsenicals, arsenolipids and arsenosugars, are examined, as well as individual variability in absorption of these compounds. Although determining health outcomes or assessing a need for regulatory policies for organic As exposure is premature, the extensive consumption of seafood globally, along with the preliminary toxicological profiles of these compounds and their confounding effect on assessing exposure to inorganic As, suggests further investigations and process-level studies on organic As are needed to fill the current gaps in knowledge. KW - Organic arsenic KW - Seafood KW - Arsenosugar KW - Arsenolipid Y1 - 2017 U6 - https://doi.org/10.1016/j.scitotenv.2016.12.113 SN - 0048-9697 SN - 1879-1026 VL - 580 SP - 266 EP - 282 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Shprits, Yuri A1 - Kellerman, Adam C . A1 - Aseev, Nikita A1 - Drozdov, Alexander A1 - Michaelis, Ingo T1 - Multi-MeV electron loss in the heart of the radiation belts JF - Geophysical research letters N2 - Significant progress has been made in recent years in understanding acceleration mechanisms in the Earth's radiation belts. In particular, a number of studies demonstrated the importance of the local acceleration by analyzing the radial profiles of phase space density (PSD) and observing building up peaks in PSD. In this study, we focus on understanding of the local loss using very similar tools. The profiles of PSD for various values of the first adiabatic invariants during the previously studied 17 January 2013 storm are presented and discussed. The profiles of PSD show clear deepening minimums consistent with the scattering by electromagnetic ion cyclotron waves. Long-term evolution shows that local minimums in PSD can persist for relatively long times. During considered interval of time the deepening minimums were observed around L* = 4 during 17 January 2013 storm and around L* = 3.5 during 1 March 2013 storm. This study shows a new method that can help identify the location, magnitude, and time of the local loss and will help quantify local loss in the future. This study also provides additional clear and definitive evidence that local loss plays a major role for the dynamics of the multi-MeV electrons. Y1 - 2017 U6 - https://doi.org/10.1002/2016GL072258 SN - 0094-8276 SN - 1944-8007 VL - 44 IS - 3 SP - 1204 EP - 1209 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Liu, Lin A1 - Cherstvy, Andrey G. A1 - Metzler, Ralf T1 - Facilitated Diffusion of Transcription Factor Proteins with Anomalous Bulk Diffusion JF - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry N2 - What are the physical laws of the diffusive search of proteins for their specific binding sites on DNA in the presence of the macromolecular crowding in cells? We performed extensive computer simulations to elucidate the protein target search on DNA. The novel feature is the viscoelastic non-Brownian protein bulk diffusion recently observed experimentally. We examine the influence of the protein-DNA binding affinity and the anomalous diffusion exponent on the target search time. In all cases an optimal search time is found. The relative contribution of intermittent three-dimensional bulk diffusion and one-dimensional sliding of proteins along the DNA is quantified. Our results are discussed in the light of recent single molecule tracking experiments, aiming at a better understanding of the influence of anomalous kinetics of proteins on the facilitated diffusion mechanism. Y1 - 2017 U6 - https://doi.org/10.1021/acs.jpcb.6b12413 SN - 1520-6106 VL - 121 SP - 1284 EP - 1289 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Cannon, Forest A1 - Carvalho, Leila M. V. A1 - Jones, Charles A1 - Norris, Jesse A1 - Bookhagen, Bodo A1 - Kiladis, George N. T1 - Effects of topographic smoothing on the simulation of winter precipitation in High Mountain Asia JF - Journal of Geophysical Research: Atmospheres N2 - Numerous studies have projected future changes in High Mountain Asia water resources based on temperature and precipitation from global circulation models (GCMs) under future climate scenarios. Although the potential benefit of such studies is immense, coarse grid-scale GCMs are unable to resolve High Mountain Asia's complex topography and thus have a biased representation of regional weather and climate. This study investigates biases in the simulation of physical mechanisms that generate snowfall and contribute to snowpack in High Mountain Asia in coarse topography experiments using the Weather Research and Forecasting model. Regional snowpack is event driven, thus 33 extreme winter orographic precipitation events are simulated at fine atmospheric resolution with 6.67 km resolution topography and smoothed 1.85° × 1.25° GCM topography. As with many modified topography experiments performed in other regions, the distribution of precipitation is highly dependent on first-order orographic effects, which dominate regional meteorology. However, we demonstrate that topographic smoothing enhances circulation in simulated extratropical cyclones, with significant impacts on orographic precipitation. Despite precipitation reductions of 28% over the highest ranges, due to reduced ascent on windward slopes, total precipitation over the study domain increased by an average of 9% in smoothed topography experiments on account of intensified extratropical cyclone dynamics and cross-barrier moisture flux. These findings identify an important source of bias in coarse-resolution simulated precipitation in High Mountain Asia, with important implications for the application of GCMs toward projecting future hydroclimate in the region. Y1 - 2017 U6 - https://doi.org/10.1002/2016JD026038 SN - 2169-897X SN - 2169-8996 VL - 122 IS - 3 SP - 1456 EP - 1474 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Müller, Juliane A1 - Engel, Tilman A1 - Kopinski, Stephan A1 - Mayer, Frank A1 - Müller, Steffen T1 - Neuromuscular trunk activation patterns in back pain patients during one-handed lifting JF - World journal of orthopedics N2 - AIM To analyze neuromuscular activity patterns of the trunk in healthy controls (H) and back pain patients (BPP) during one-handed lifting of light to heavy loads. METHODS RESULTS Seven subjects (3m/4f; 32 +/- 7 years; 171 +/- 7 cm; 65 +/- 11 kg) were assigned to BPP (pain grade >= 2) and 36 (13m/23f; 28 +/- 8 years; 174 +/- 10 cm; 71 +/- 12 kg) to H (pain grade <= 1). H and BPP did not differ significantly in anthropometrics (P > 0.05). All subjects were able to lift the light and middle loads, but 57% of BPP and 22% of H were not able to lift the heavy load (all women) chi(2) analysis revealed statistically significant differences in task failure between H vs BPP (P = 0.03). EMG-RMS ranged from 33% +/- 10%/30% +/- 9% (DL, 1 kg) to 356% +/- 148%/283% +/- 80% (VR, 20 kg) in H/BPP with no statistical difference between groups regardless of load (P > 0.05). However, the EMG-RMS of the VR was greatest in all lifting tasks for both groups and increased with heavier loads. CONCLUSION Heavier loading leads to an increase (2-to 3-fold) in trunk muscle activity with comparable patterns. Heavy loading (20 kg) leads to task failure, especially in women with back pain. KW - Lifting KW - Core KW - Trunk KW - EMG KW - MISPEX Y1 - 2016 U6 - https://doi.org/10.5312/wjo.v8.i2.142 SN - 2218-5836 VL - 8 IS - 2 SP - 142 EP - 148 PB - Baishideng Publishing Group CY - Pleasanton ER - TY - JOUR A1 - Smirnov, Lev A. A1 - Osipov, Grigory V. A1 - Pikovskij, Arkadij T1 - Chimera patterns in the Kuramoto-Battogtokh model JF - Journal of physics : A, Mathematical and theoretical N2 - Kuramoto and Battogtokh (2002 Nonlinear Phenom. Complex Syst. 5 380) discovered chimera states represented by stable coexisting synchrony and asynchrony domains in a lattice of coupled oscillators. After a reformulation in terms of a local order parameter, the problem can be reduced to partial differential equations. We find uniformly rotating, spatially periodic chimera patterns as solutions of a reversible ordinary differential equation, and demonstrate a plethora of such states. In the limit of neutral coupling they reduce to analytical solutions in the form of one-and two-point chimera patterns as well as localized chimera solitons. Patterns at weakly attracting coupling are characterized by virtue of a perturbative approach. Stability analysis reveals that only the simplest chimeras with one synchronous region are stable. KW - nonlocal coupled oscillators KW - chimera state KW - coarse-grained order parameter KW - Ott-Antonsen reduction KW - perturbation approach KW - linear stability analysis Y1 - 2017 U6 - https://doi.org/10.1088/1751-8121/aa55f1 SN - 1751-8113 SN - 1751-8121 VL - 50 IS - 8 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Reschke, Stefan A1 - Mebs, Stefan A1 - Sigfridsson-Clauss, Kajsa G. V. A1 - Kositzki, Ramona A1 - Leimkühler, Silke A1 - Haumann, Michael T1 - Protonation and Sulfido versus Oxo Ligation Changes at the Molybdenum Cofactor in Xanthine Dehydrogenase (XDH) Variants Studied by X-ray Absorption Spectroscopy JF - Inorganic chemistry N2 - Enzymes of the xanthine oxidase family are among the best characterized mononuclear molybdenum enzymes. Open questions about their mechanism of transfer of an oxygen atom to the substrate remain. The enzymes share a molybdenum cofactor (Moco) with the metal ion binding a molybdopterin (MPT) molecule via its dithiolene function and terminal sulfur and oxygen groups. For xanthine dehydrogenase (XDH) from the bacterium Rhodobacter capsulatus, we used X-ray absorption spectroscopy to determine the Mo site structure, its changes in a pH range of 5-10, and the influence of amino acids (Glu730 and Gln179) close to Moco in wild-type (WT), Q179A, and E730A variants, complemented by enzyme kinetics and quantum chemical studies. Oxidized WT and Q179A revealed a similar Mo (VI) ion with each one MPT, Mo=O, Mo-O-, and Mo=S ligand, and a weak Mo-O(E730) bond at alkaline pH. Protonation of an oxo to a hydroxo (OH) ligand (pK similar to 6.8) causes inhibition of XDH at acidic pH, whereas deprotonated xanthine (pK similar to 8.8) is an inhibitor at alkaline pH. A similar acidic pK for the WT and Q179A. variants, as well as the metrical parameters of the Mo site and density functional theory calculations, suggested protonation at the equatorial oxo group. The sulfido was replaced with an oxo ligand in the inactive E730A variant, further showing another oxo and one Mo OH ligand at Mo, which are independent of pH. Our findings suggest a reaction mechanism for XDH in which an initial oxo rather than a hydroxo group and the sulfido ligand are essential for xanthine oxidation. Y1 - 2017 U6 - https://doi.org/10.1021/acs.inorgchem.6b02846 SN - 0020-1669 SN - 1520-510X VL - 56 IS - 4 SP - 2165 EP - 2176 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Abeysekara, A. U. A1 - Archambault, S. A1 - Archer, A. A1 - Benbow, Wystan A1 - Bird, Ralph A1 - Buchovecky, M. A1 - Buckley, J. H. A1 - Bugaev, V. A1 - Byrum, K. A1 - Cerruti, M. A1 - Chen, X. A1 - Ciupik, L. A1 - Cui, W. A1 - Dickinson, H. J. A1 - Eisch, J. D. A1 - Errando, M. A1 - Falcone, A. A1 - Feng, Q. A1 - Finley, J. P. A1 - Fleischhack, H. A1 - Fortson, L. A1 - Furniss, A. A1 - Gillanders, G. H. A1 - Griffin, S. A1 - Grube, J. A1 - Hutten, M. A1 - Hakansson, N. A1 - Hanna, D. A1 - Holder, J. A1 - Humensky, T. B. A1 - Johnson, C. A. A1 - Kaaret, P. A1 - Kar, P. A1 - Kertzman, M. A1 - Kieda, D. A1 - Krause, M. A1 - Krennrich, F. A1 - Kumar, S. A1 - Lang, M. J. A1 - Maier, G. A1 - McArthur, S. A1 - McCann, A. A1 - Meagher, K. A1 - Moriarty, P. A1 - Mukherjee, R. A1 - Nguyen, T. A1 - Nieto, D. A1 - Ong, R. A. A1 - Otte, A. N. A1 - Park, N. A1 - Pelassa, V. A1 - Pohl, Martin A1 - Popkow, A. A1 - Pueschel, Elisa A1 - Quinn, J. A1 - Ragan, K. A1 - Reynolds, P. T. A1 - Richards, G. T. A1 - Roache, E. A1 - Rulten, C. A1 - Santander, M. A1 - Sembroski, G. H. A1 - Shahinyan, K. A1 - Staszak, D. A1 - Telezhinsky, Igor O. A1 - Tucci, J. V. A1 - Tyler, J. A1 - Wakely, S. P. A1 - Weiner, O. M. A1 - Weinstein, A. A1 - Wilhelm, Alina A1 - Williams, D. A. A1 - Fegan, S. A1 - Giebels, B. A1 - Horan, D. A1 - Berdyugin, A. A1 - Kuan, J. A1 - Lindfors, E. A1 - Nilsson, K. A1 - Oksanen, A. A1 - Prokoph, H. A1 - Reinthal, R. A1 - Takalo, L. A1 - Zefi, F. T1 - A Luminous and Isolated Gamma-Ray Flare from the Blazar B2 1215+30 JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - B2 1215+30 is a BL-Lac-type blazar that was first detected at TeV energies by the MAGIC atmospheric Cherenkov telescopes and subsequently confirmed by the Very Energetic Radiation Imaging Telescope Array System (VERITAS) observatory with data collected between 2009 and 2012. In 2014 February 08, VERITAS detected a large-amplitude flare from B2. 1215+30 during routine monitoring observations of the blazar 1ES. 1218+304, located in the same field of view. The TeV flux reached 2.4 times the Crab Nebula flux with a variability timescale of <3.6 hr. Multiwavelength observations with Fermi-LAT, Swift, and the Tuorla Observatory revealed a correlated high GeV flux state and no significant optical counterpart to the flare, with a spectral energy distribution where the gamma-ray luminosity exceeds the synchrotron luminosity. When interpreted in the framework of a onezone leptonic model, the observed emission implies a high degree of beaming, with Doppler factor delta > 10, and an electron population with spectral index p < 2.3. KW - BL Lacertae objects: individual (B2 1215+30, VER J1217+301) KW - galaxies: active KW - galaxies: jets KW - galaxies: nuclei KW - gamma rays: galaxies Y1 - 2017 U6 - https://doi.org/10.3847/1538-4357/836/2/205 SN - 0004-637X SN - 1538-4357 VL - 836 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Ferrera, Isabel A1 - Sarmento, Hugo A1 - Priscu, John C. A1 - Chiuchiolo, Amy A1 - Gonzalez, Jose M. A1 - Grossart, Hans-Peter T1 - Diversity and Distribution of Freshwater Aerobic Anoxygenic Phototrophic Bacteria across a Wide Latitudinal Gradient JF - Frontiers in microbiology N2 - Aerobic anoxygenic phototrophs (AAPs) have been shown to exist in numerous marine and brackish environments where they are hypothesized to play important ecological roles. Despite their potential significance, the study of freshwater AAPs is in its infancy and limited to local investigations. Here, we explore the occurrence, diversity and distribution of AAPs in lakes covering a wide latitudinal gradient: Mongolian and German lakes located in temperate regions of Eurasia, tropical Great East African lakes, and polar permanently ice-covered Antarctic lakes. Our results show a widespread distribution of AAPs in lakes with contrasting environmental conditions and confirm that this group is composed of different members of the Alpha- and Betaproteobacteria. While latitude does not seem to strongly influence AAP abundance, clear patterns of community structure and composition along geographic regions were observed as indicated by a strong macro-geographical signal in the taxonomical composition of AAPs. Overall, our results suggest that the distribution patterns of freshwater AAPs are likely driven by a combination of small-scale environmental conditions (specific of each lake and region) and large-scale geographic factors (climatic regions across a latitudinal gradient). KW - AAP bacteria KW - photoheterotrophy KW - pufM gene KW - freshwater lakes KW - latitudinal gradients KW - biogeography Y1 - 2017 U6 - https://doi.org/10.3389/fmicb.2017.00175 SN - 1664-302X VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Godec, Aljaž A1 - Metzler, Ralf T1 - First passage time statistics for two-channel diffusion JF - Journal of physics : A, Mathematical and theoretical N2 - We present rigorous results for the mean first passage time and first passage time statistics for two-channel Markov additive diffusion in a 3-dimensional spherical domain. Inspired by biophysical examples we assume that the particle can only recognise the target in one of the modes, which is shown to effect a non-trivial first passage behaviour. We also address the scenario of intermittent immobilisation. In both cases we prove that despite the perfectly non-recurrent motion of two-channel Markov additive diffusion in 3 dimensions the first passage statistics at long times do not display Poisson-like behaviour if none of the phases has a vanishing diffusion coefficient. This stands in stark contrast to the standard (one-channel) Markov diffusion counterpart. We also discuss the relevance of our results in the context of cellular signalling. KW - first passage time KW - Markov additive processes KW - Fokker-Planck equation KW - random search processes KW - coupled initial boundary value problem KW - cellular signalling KW - asymptotic analysis Y1 - 2017 U6 - https://doi.org/10.1088/1751-8121/aa5204 SN - 1751-8113 SN - 1751-8121 VL - 50 IS - 8 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Gruebner, Oliver A1 - Rapp, Michael A. A1 - Adli, Mazda A1 - Kluge, Ulrike A1 - Galea, Sandro A1 - Heinz, Andreas T1 - Cities and Mental Health JF - Deutsches Ärzteblatt international : a weekly online journal of clinical medicine and public health N2 - Background: More than half of the global population currently lives in cities, with an increasing trend for further urbanization. Living in cities is associated with increased population density, traffic noise and pollution, but also with better access to health care and other commodities. Methods: This review is based on a selective literature search, providing an overview of the risk factors for mental illness in urban centers. Results: Studies have shown that the risk for serious mental illness is generally higher in cities compared to rural areas. Epidemiological studies have associated growing up and living in cities with a considerably higher risk for schizophrenia. However, correlation is not causation and living in poverty can both contribute to and result from impairments associated with poor mental health. Social isolation and discrimination as well as poverty in the neighborhood contribute to the mental health burden while little is known about specific inter actions between such factors and the built environment. Conclusion: Further insights on the interaction between spatial heterogeneity of neighborhood resources and socio-ecological factors is warranted and requires interdisciplinary research. Y1 - 2017 U6 - https://doi.org/10.3238/arztebl.2017.0121 SN - 1866-0452 VL - 114 IS - 8 SP - 121 EP - 127 PB - Dt. Ärzte-Verl. CY - Cologne ER - TY - JOUR A1 - Gorobtsov, O. Yu. A1 - Mercurio, G. A1 - Brenner, G. A1 - Lorenz, Ulf A1 - Gerasimova, N. A1 - Kurta, R. P. A1 - Hieke, F. A1 - Skopintsev, P. A1 - Zaluzhnyy, I. A1 - Lazarev, S. A1 - Dzhigaev, D. A1 - Rose, M. A1 - Singer, A. A1 - Wurth, W. A1 - Vartanyants, I. A. T1 - Statistical properties of a free-electron laser revealed by Hanbury Brown-Twiss interferometry JF - Physical review : A, Atomic, molecular, and optical physics N2 - We present a comprehensive experimental analysis of statistical properties of the self-amplified spontaneous emission free-electron laser (FEL) FLASH by means of Hanbury Brown and Twiss interferometry. The experiments were performed at FEL wavelengths of 5.5, 13.4, and 20.8 nm. We determined the second-order intensity correlation function for all wavelengths and different operation conditions of FLASH. In all experiments a high degree of spatial coherence (above 50%) was obtained. Our analysis performed in spatial and spectral domains provided us with the independent measurements of an average pulse duration of the FEL that were below 60 fs. To explain the complicated behavior of the second-order intensity correlation function we developed an advanced theoretical model that includes the presence of multiple beams and external positional jitter of the FEL pulses. By this analysis we determined that in one of the experiments external positional jitter was about 25% of the beam size. We envision that methods developed in our study will be used widely for analysis and diagnostics of FEL radiation. Y1 - 2017 U6 - https://doi.org/10.1103/PhysRevA.95.023843 SN - 2469-9926 SN - 2469-9934 VL - 95 IS - 2 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Li, Shaoyang A1 - Moreno Switt, Marcos A1 - Bedford, Jonathan A1 - Rosenau, Matthias A1 - Heidbach, Oliver A1 - Melnick, Daniel A1 - Oncken, Onno T1 - Postseismic uplift of the Andes following the 2010 Maule earthquake BT - Implications for mantle rheology JF - Geophysical research letters N2 - Postseismic surface deformation associated with great subduction earthquakes is controlled by asthenosphere rheology, frictional properties of the fault, and structural complexity. Here by modeling GPS displacements in the 6 years following the 2010 M-w 8.8 Maule earthquake in Chile, we investigate the impact of heterogeneous viscosity distribution in the South American subcontinental asthenosphere on the 3-D postseismic deformation pattern. The observed postseismic deformation is characterized by flexure of the South America plate with peak uplift in the Andean mountain range and subsidence in the hinterland. We find that, at the time scale of observation, over 2 orders of magnitude gradual increase in asthenosphere viscosity from the arc area toward the cratonic hinterland is needed to jointly explain horizontal and vertical displacements. Our findings present an efficient method to estimate spatial variations of viscosity, which clearly improves the fitting to the vertical signal of deformation. Lateral changes in asthenosphere viscosity can be correlated with the thermomechanical transition from weak subvolcanic arc mantle to strong subcratonic mantle, thus suggesting a stationary heterogeneous viscosity structure. However, we cannot rule out a transient viscosity structure (e.g., power law rheology) with the short time span of observation. Y1 - 2017 U6 - https://doi.org/10.1002/2016GL071995 SN - 0094-8276 SN - 1944-8007 VL - 44 IS - 4 SP - 1768 EP - 1776 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Riedel, M. A1 - Sabir, N. A1 - Scheller, Frieder W. A1 - Parak, Wolfgang J. A1 - Lisdat, Fred T1 - Connecting quantum dots with enzymes BT - mediator-based approaches for the light-directed read-out of glucose and fructose oxidation JF - Nanoscale N2 - The combination of the biocatalytic features of enzymes with the unique physical properties of nanoparticles in a biohybrid system provides a promising approach for the development of advanced bioelectrocatalytic devices. This study describes the construction of photoelectrochemical signal chains based on CdSe/ZnS quantum dot (QD) modified gold electrodes as light switchable elements, and low molecular weight redox molecules for the combination with different biocatalysts. Photoelectrochemical and photoluminescence experiments verify that electron transfer can be achieved between the redox molecules hexacyanoferrate and ferrocene, and the QDs under illumination. Since for both redox mediators a concentration dependent photocurrent change has been found, light switchable enzymatic signal chains are built up with fructose dehydrogenase (FDH) and pyrroloquinoline quinone-dependent glucose dehydrogenase ((PQQ) GDH) for the detection of sugars. After immobilization of the enzymes at the QD electrode the biocatalytic oxidation of the substrates can be followed by conversion of the redox mediator in solution and subsequent detection at the QD electrode. Furthermore, (PQQ) GDH has been assembled together with ferrocenecarboxylic acid on top of the QD electrode for the construction of a funtional biohybrid architecture, showing that electron transfer can be realized from the enzyme over the redox mediator to the QDs and subsequently to the electrode in a completely immobilized fashion. The results obtained here do not only provide the basis for light-switchable biosensing and bioelectrocatalytic applications, but may also open the way for self-driven point-of-care systems by combination with solar cell approaches (power generation at the QD electrode by enzymatic substrate consumption). Y1 - 2017 U6 - https://doi.org/10.1039/c7nr00091j SN - 2040-3364 SN - 2040-3372 VL - 9 SP - 2814 EP - 2823 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Plötz, Per-Arno A1 - Megow, Jörg A1 - Niehaus, Thomas A1 - Kühn, Oliver T1 - Spectral densities for Frenkel exciton dynamics in molecular crystals BT - a TD-DFTB approach JF - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr N2 - Effects of thermal fluctuations on the electronic excitation energies and intermonomeric Coulomb couplings are investigated for a perylene-tetracarboxylic-diimidecrystal. To this end, time dependent density functional theory based tight binding (TD-DFTB) in the linear response formulation is used in combination with electronic ground state classical molecular dynamics. As a result, a parametrized Frenkel exciton Hamiltonian is obtained, with the effect of exciton-vibrational coupling being described by spectral densities. Employing dynamically defined normal modes, these spectral densities are analyzed in great detail, thus providing insight into the effect of specific intramolecular motions on excitation energies and Coulomb couplings. This distinguishes the present method from approaches using fixed transition densities. The efficiency by which intramolecular contributions to the spectral density can be calculated is a clear advantage of this method as compared with standard TD-DFT. Published by AIP Publishing. Y1 - 2017 U6 - https://doi.org/10.1063/1.4976625 SN - 0021-9606 SN - 1089-7690 VL - 146 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Barthold, Frauke Katrin A1 - Turner, Benjamin L. A1 - Elsenbeer, Helmut A1 - Zimmermann, Alexander T1 - A hydrochemical approach to quantify the role of return flow in a surface flow-dominated catchment JF - Hydrological processes N2 - Stormflow generation in headwater catchments dominated by subsurface flow has been studied extensively, yet catchments dominated by surface flow have received less attention. We addressed this by testing whether stormflow chemistry is controlled by either (a) the event-water signature of overland flow, or (b) the pre-event water signature of return flow. We used a high-resolution hydrochemical data set of stormflow and end-members of multiple storms in an end-member mixing analysis to determine the number of end-members needed to explain stormflow, characterize and identify potential end-members, calculate their contributions to stormflow, and develop a conceptual model of stormflow. The arrangement and relative positioning of end-members in stormflow mixing space suggest that saturation excess overland flow (26-48%) and return flow from two different subsurface storage pools (17-53%) are both similarly important for stormflow. These results suggest that pipes and fractures are important flow paths to rapidly release stored water and highlight the value of within-event resolution hydrochemical data to assess the full range and dynamics of flow paths. KW - EMMA KW - hydrochemistry KW - overland flow KW - return flow KW - stormflow generation Y1 - 2016 U6 - https://doi.org/10.1002/hyp.11083 SN - 0885-6087 SN - 1099-1085 VL - 31 IS - 5 SP - 1018 EP - 1033 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Petereit, Johannes A1 - Pikovskij, Arkadij T1 - Chaos synchronization by nonlinear coupling JF - Communications in nonlinear science & numerical simulation N2 - We study synchronization properties of three nonlinearly coupled chaotic maps. Coupling is introduced in such a way, that it cannot be reduced to pairwise terms, but includes combined action of all interacting units. For two models of nonlinear coupling we characterize the transition to complete synchrony, as well as partially synchronized states. Relation to hypernetworks of chaotic units is also discussed. KW - Chaos synchronization KW - Partial synchrony KW - Intermittency KW - Hypernetwork Y1 - 2016 U6 - https://doi.org/10.1016/j.cnsns.2016.09.002 SN - 1007-5704 SN - 1878-7274 VL - 44 SP - 344 EP - 351 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Koc-Januchta, Marta A1 - Höffler, Tim A1 - Thoma, Gun-Brit A1 - Prechtl, Helmut A1 - Leutner, Detlev T1 - Visualizers versus verbalizers BT - Effects of cognitive style on learning with texts and pictures - An eye-tracking study JF - Computers in human behavior N2 - This study was conducted in order to examine the differences between visualizers and verbalizers in the way they gaze at pictures and texts while learning. Using a collection of questionnaires, college students were classified according to their visual or verbal cognitive style and were asked to learn about two different, in terms of subject and type of knowledge, topics by means of text-picture combinations. Eye-tracking was used to investigate their gaze behavior. The results show that visualizers spent significantly more time inspecting pictures than verbalizers, while verbalizers spent more time inspecting texts. Results also suggest that both visualizers' and verbalizers' way of learning is active but mostly within areas providing the source of information in line with their cognitive style (pictures or text). Verbalizers tended to enter non-informative, irrelevant areas of pictures sooner than visualizers. The comparison of learning outcomes showed that the group of visualizers achieved better results than the group of verbalizers on a comprehension test. KW - Cognitive style KW - Verbalizer KW - Visualizer KW - Eye-tracking KW - Multimedia learning Y1 - 2016 U6 - https://doi.org/10.1016/j.chb.2016.11.028 SN - 0747-5632 SN - 1873-7692 VL - 68 SP - 170 EP - 179 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Kolk, Jens A1 - Naaf, Tobias A1 - Wulf, Monika T1 - Paying the colonization credit BT - converging plant species richness in ancient and post-agricultural forests in NE Germany over five decades JF - Biodiversity and conservation N2 - Massive historical land cover changes in the Central European lowlands have resulted in a forest distribution that now comprises small remnants of ancient forests and more recently established post-agricultural forests. Here, land-use history is considered a key driver of recent herb-layer community changes, where an extinction debt in ancient forest remnants and/or a colonization credit in post-agricultural forests are being paid over time. On a regional scale, these payments should in theory lead toward a convergence in species richness between ancient and post-agricultural forests over time. In this study, we tested this assumption with a resurvey of 117 semi-permanent plots in the well-studied deciduous forests of the Prignitz region (Brandenburg, NE Germany), where we knew that the plant communities of post-agricultural stands exhibit a colonization credit while the extinction debt in ancient stands has largely been paid. We compared changes in the species richness of all herb layer species, forest specialists and ancient forest indicator species between ancient and post-agricultural stands with linear mixed effect models and determined the influence of patch connectivity on the magnitude of species richness changes. Species richness increased overall, but the richness of forest specialists increased significantly more in post-agricultural stands and was positively influenced by higher patch connectivity, indicating a convergence in species richness between the ancient and postagricultural stands. Furthermore, the richness of ancient forest indicator species only increased significantly in post-agricultural stands. For the first time, we were able to verify a gradual payment of the colonization credit in post-agricultural forest stands using a comparison of actual changes in temporal species richness. KW - Herb layer KW - Land-use history KW - Land-use legacy KW - Long-term change KW - Resurvey KW - Temperate forest Y1 - 2016 U6 - https://doi.org/10.1007/s10531-016-1271-y SN - 0960-3115 SN - 1572-9710 VL - 26 SP - 735 EP - 755 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Hammer, Conny A1 - Fäh, Donat A1 - Ohrnberger, Matthias T1 - Automatic detection of wet-snow avalanche seismic signals JF - Natural hazards : journal of the International Society for the Prevention and Mitigation of Natural Hazards N2 - Avalanche activity is an important factor when estimating the regional avalanche danger. Moreover, a complete and detailed picture of avalanche activity is needed to understand the processes that lead to natural avalanche release. Currently, information on avalanche activity is mainly obtained through visual observations. However, this involves large uncertainties in the number and release times, influencing the subsequent analysis. Therefore, alternative methods for the remote detection of snow avalanches in particular in non-observed areas are highly desirable. In this study, we use the excited ground vibration to identify avalanches automatically. The specific seismic signature of avalanches facilitates the objective detection by a recently developed classification procedure. A probabilistic description of the signals, called hidden Markov models, allows the robust identification of corresponding signals in the continuous data stream. The procedure is based upon learning a general background model from continuous seismic data. Then, a single reference waveform is used to update an event-specific classifier. Thus, a minimum amount of training data is required by constructing such a classifier on the fly. In this study, we processed five days of continuous data recorded in the Swiss Alps during the avalanche winter 1999. With the restriction of testing large wet-snow avalanches only, the presented approach achieved very convincing results. We successfully detect avalanches over a large volume and distance range. Ninety-two percentage of all detections (43 out of 47) could be confirmed as avalanche events; only four false alarms are reported. We see a clear dependence of recognition capability on run-out distance and source-receiver distance of the observed events: Avalanches are detectable up to a source-receiver distance of eight times the avalanche length. Implications for analyzing a more comprehensive data set (smaller events and different flow regimes) are discussed in detail. KW - Snow avalanche recognition KW - Automatic detection KW - Avalanche forecasting KW - Hidden Markov model Y1 - 2016 U6 - https://doi.org/10.1007/s11069-016-2707-0 SN - 0921-030X SN - 1573-0840 VL - 86 SP - 601 EP - 618 PB - Springer CY - New York ER - TY - JOUR A1 - Loritz, Ralf A1 - Hassler, Sibylle K. A1 - Jackisch, Conrad A1 - Allroggen, Niklas A1 - van Schaik, Loes A1 - Wienhöfer, Jan A1 - Zehe, Erwin T1 - Picturing and modeling catchments by representative hillslopes JF - Hydrology and earth system sciences : HESS N2 - This study explores the suitability of a single hillslope as a parsimonious representation of a catchment in a physically based model. We test this hypothesis by picturing two distinctly different catchments in perceptual models and translating these pictures into parametric setups of 2-D physically based hillslope models. The model parametrizations are based on a comprehensive field data set, expert knowledge and process-based reasoning. Evaluation against streamflow data highlights that both models predicted the annual pattern of streamflow generation as well as the hydrographs acceptably. However, a look beyond performance measures revealed deficiencies in streamflow simulations during the summer season and during individual rainfall-runoff events as well as a mismatch between observed and simulated soil water dynamics. Some of these shortcomings can be related to our perception of the systems and to the chosen hydrological model, while others point to limitations of the representative hillslope concept itself. Nevertheless, our results confirm that representative hillslope models are a suitable tool to assess the importance of different data sources as well as to challenge our perception of the dominant hydrological processes we want to represent therein. Consequently, these models are a promising step forward in the search for the optimal representation of catchments in physically based models. Y1 - 2017 U6 - https://doi.org/10.5194/hess-21-1225-2017 SN - 1027-5606 SN - 1607-7938 VL - 21 IS - 2 SP - 1225 EP - 1249 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Ramachandran, Varsha A1 - Das, S. R. A1 - Tej, A. A1 - Vig, S. A1 - Ghosh, S. K. A1 - Ojha, D. K. T1 - Radio and infrared study of the star-forming region IRAS 20286+4105 JF - Monthly notices of the Royal Astronomical Society N2 - In this paper, we present a multi wavelength investigation of the star-forming complex IRAS 20286+4105, located in the Cygnus X region. Near-infrared K-band data are used to revisit the cluster/stellar group identified in previous studies. Radio continuum observations at 610 and 1280 MHz show the presence of a H II region possibly powered by a star of spectral type B0-B0.5. The cometary morphology of the ionized region is explained by invoking the bowshock model, where the likely association with a nearby supernova remnant is also explored. A compact radio knot with a non-thermal spectral index is detected towards the centre of the cloud. Mid-infrared data from the Spitzer Legacy Survey of the Cygnus X region show the presence of six Class I young stellar objects inside the cloud. Thermal dust emission in this complex is modelled using Herschel far-infrared data to generate dust temperature and column density maps. Herschel images also show the presence of two clumps in this region, the masses of which are estimated to be similar to 175 and 30 M-circle dot. The mass-radius relation and the surface density of the clumps mean that they do not qualify as massive star-forming sites. An overall picture of a runaway star ionizing the cloud and a triggered population of intermediatemass, Class I sources located towards the cloud centre emerges from this multiwavelength study. Variation in the dust emissivity spectral index is shown to exist in this region and is seen to have an inverse relation with the dust temperature. KW - stars: formation KW - H II regions KW - ISM: individual objects: IRAS 20286+4105 KW - radio continuum: ISM Y1 - 2016 U6 - https://doi.org/10.1093/mnras/stw2906 SN - 0035-8711 SN - 1365-2966 VL - 465 IS - 4 SP - 4753 EP - 4771 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Mucha, Anne T1 - Past interpretation and graded tense in Medumba JF - Natural language semantics : an international journal of semantics and its interfaces in grammar N2 - This paper provides a formal semantic analysis of past interpretation in Medumba (Grassfields Bantu), a graded tense language. Based on original fieldwork, the study explores the empirical behavior and meaning contribution of graded past morphemes in Medumba and relates these to the account of the phenomenon proposed in Cable (Nat Lang Semant 21:219-276, 2013) for GA (c) ky. Investigation reveals that the behavior of Medumba gradedness markers differs from that of their GA (c) ky counterparts in meaningful ways and, more broadly, discourages an analysis as presuppositional eventuality or reference time modifiers. Instead, the Medumba markers are most appropriately analyzed as quantificational tenses. It also turns out that Medumba, though belonging to the typological class of graded tense languages, shows intriguing similarities to genuinely tenseless languages in allowing for temporally unmarked sentences and exploiting aspectual and pragmatic cues for reference time resolution. The more general cross-linguistic implication of the study is that the set of languages often subsumed under the label "graded tense" does not in fact form a natural class and that more case-by-case research is needed to refine this category. KW - Graded tense KW - Past interpretation KW - Grassfields Bantu Y1 - 2016 U6 - https://doi.org/10.1007/s11050-016-9128-1 SN - 0925-854X SN - 1572-865X VL - 25 SP - 1 EP - 52 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Frodl, Thomas A1 - Janowitz, Deborah A1 - Schmaal, Lianne A1 - Tozzi, Leonardo A1 - Dobrowolny, Henrik A1 - Stein, Dan J. A1 - Veltman, Dick J. A1 - Wittfeld, Katharina A1 - van Erp, Theo G. M. A1 - Jahanshad, Neda A1 - Block, Andrea A1 - Hegenscheid, Katrin A1 - Voelzke, Henry A1 - Lagopoulos, Jim A1 - Hatton, Sean N. A1 - Hickie, Ian B. A1 - Frey, Eva Maria A1 - Carballedo, Angela A1 - Brooks, Samantha J. A1 - Vuletic, Daniella A1 - Uhlmann, Anne A1 - Veer, Ilya M. A1 - Walter, Henrik A1 - Schnell, Knut A1 - Grotegerd, Dominik A1 - Arolt, Volker A1 - Kugel, Harald A1 - Schramm, Elisabeth A1 - Konrad, Carsten A1 - Zurowski, Bartosz A1 - Baune, Bernhard T. A1 - van der Wee, Nic J. A. A1 - van Tol, Marie-Jose A1 - Penninx, Brenda W. J. H. A1 - Thompson, Paul M. A1 - Hibar, Derrek P. A1 - Dannlowski, Udo A1 - Grabe, Hans J. T1 - Childhood adversity impacts on brain subcortical structures relevant to depression JF - Journal of psychiatric research N2 - Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd. KW - Depression KW - Childhood adversity KW - MRI KW - Caudate KW - Hippocampus KW - ENIGMA Y1 - 2016 U6 - https://doi.org/10.1016/j.jpsychires.2016.11.010 SN - 0022-3956 SN - 1879-1379 VL - 86 SP - 58 EP - 65 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Muschalla, Beate T1 - Is it a Case of "Work-Anxiety" When Patients Report Bad Workplace Characteristics and Low Work Ability? JF - Journal of Occupational Rehabilitation N2 - Aims Work-anxiety may produce overly negative views of the workplace that impair provider efforts to assess work ability from patient self-report. This study explores the empirical relationships between patient-reported workplace characteristics, work-anxiety, and subjective and objective work ability measures. Methods 125 patients in medical rehabilitation before vocational reintegration were interviewed concerning their vocational situation, and filled in a questionnaire on work-anxiety, subjective mental work ability and perceived workplace characteristics. Treating physicians gave independent socio-medical judgments concerning the patients’ work ability and impairment, and need for supportive means for vocational reintegration. Results Patients with high work-anxiety reported more negative workplace characteristics. Low judgments of work ability were correlated with problematic workplace characteristics. When controlled for work-anxiety, subjective work ability remained related only with social workplace characteristics and with work achievement demands, but independent from situational or task characteristics. Sick leave duration and physicians’ judgment of work ability were not significantly related to patient-reported workplace characteristics. Conclusions In socio-medical work ability assessments, patients with high work-anxiety may over-report negative workplace characteristics that can confound provider estimates of work ability. Assessing work-anxiety may be important to assess readiness for returning to work and initiating work-directed treatments. KW - Work anxiety KW - Work ability KW - Workplace KW - Sick leave KW - Work characteristics Y1 - 2016 U6 - https://doi.org/10.1007/s10926-016-9637-2 SN - 1053-0487 SN - 1573-3688 VL - 27 SP - 106 EP - 114 PB - Springer CY - New York ER - TY - JOUR A1 - Braig, Friederike A1 - Kriegs, Malte A1 - Voigtlaender, Minna A1 - Habel, Beate A1 - Grob, Tobias A1 - Biskup, Karina A1 - Blanchard, Veronique A1 - Sack, Markus A1 - Thalhammer, Anja A1 - Ben Batalla, Isabel A1 - Braren, Ingke A1 - Laban, Simon A1 - Danielczyk, Antje A1 - Goletz, Steffen A1 - Jakubowicz, Elzbieta A1 - Maerkl, Bruno A1 - Trepel, Martin A1 - Knecht, Rainald A1 - Riecken, Kristoffer A1 - Fehse, Boris A1 - Loges, Sonja A1 - Bokemeyer, Carsten A1 - Binder, Mascha T1 - Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K-521 Polymorphism JF - Cancer research N2 - Head and neck squamous cell carcinomas (HNSCC) exhibiting resistance to the EGFR-targeting drug cetuximab poses a challenge to their effective clinical management. Here, we report a specific mechanism of resistance in this setting based upon the presence of a single nucleotide polymorphism encoding EGFR-K-521 (K-allele), which is expressed in > 40% of HNSCC cases. Patients expressing the K-allele showed significantly shorter progressionfree survival upon palliative treatment with cetuximab plus chemotherapy or radiation. In several EGFR-mediated cancer models, cetuximab failed to inhibit downstream signaling or to kill cells harboring a high K-allele frequency. Cetuximab affinity for EGFR-K-521 was reduced slightly, but ligand-mediated EGFR acti-vation was intact. We found a lack of glycan sialyation on EGFR-K-521 that associated with reduced protein stability, suggesting a structural basis for reduced cetuximab efficacy. CetuGEX, an antibody with optimized Fc glycosylation targeting the same epitope as cetuximab, restored HNSCC sensitivity in a manner associated with antibody-dependent cellular cytotoxicity rather than EGFR pathway inhibition. Overall, our results highlight EGFR-K-521 expression as a key mechanism of cetuximab resistance to evaluate prospectively as a predictive biomarker in HNSCC patients. Further, they offer a preclinical rationale for the use of ADCC-optimized antibodies to treat tumors harboring this EGFR isoform. Y1 - 2017 U6 - https://doi.org/10.1158/0008-5472.CAN-16-0754 SN - 0008-5472 SN - 1538-7445 VL - 77 IS - 5 SP - 1188 EP - 1199 PB - American Association for Cancer Research CY - Philadelphia ER - TY - JOUR A1 - Spahn, Hannah T1 - Rezension zu: Helo, Ari, Thomas Jefferson's ethics and the politics of human progress: the morality of a slaveholder. - New York, NY: Cambridge Univ. Press, 2014. - ISBN 978-1-107-04078-6 JF - Journal of the Early Republic KW - Thomas Jefferson KW - Ethics KW - Progress KW - Racism KW - Slavery Y1 - 2017 U6 - https://doi.org/10.1353/jer.2017.0010 SN - 0275-1275 SN - 1553-0620 VL - 37 IS - 1 SP - 170 EP - 173 PB - University of Pennsylvania Press CY - Philadelphia ER - TY - JOUR A1 - Krahé, Barbara A1 - Berger, Anja T1 - Longitudinal pathways of sexual victimization, sexual self-esteem, and depression in women and men JF - Psychological Trauma: Theory, Research, Practice, and Policy N2 - Objective: This article presents a longitudinal analysis of the links between sexual assault victimization, depression, and sexual self-esteem by examining their cross-lagged paths among both men and women. Method: Male and female college students (N = 2,425) in Germany participated in the study that comprised 3 data waves in their first, second, and third year of university, separated by 12-month intervals. Sexual assault victimization was assessed at Time 1 (T1) since the age of 14 and at Time 2 (T2) and Time 3 (T3) for the last 12 months. Depression and sexual self-esteem were measured at each wave. Results: Random-intercept cross-lagged panel analyses, controlling for individual differences in depression and sexual self-esteem, showed that sexual assault at T1 predicted depression and lower sexual self-esteem at T2, and depression and lower self-esteem at T2 predicted sexual assault victimization at T3. In addition, significant paths were found from T1 depression to T2 sexual assault victimization and from T2 sexual assault victimization to depression at T3. Sexual victimization at T1 was indirectly linked to sexual victimization at T3 via depression at T2. Both depression and sexual self-esteem at T1 were indirectly linked to sexual victimization at T3. The paths did not differ significantly between men and women. Conclusion: Sexual assault victimization was shown to be a risk factor for both depression as a general mental health indicator and lowered sexual self-esteem as a specific outcome in the domain of sexuality. Moreover, depression and sexual self-esteem increased the vulnerability for sexual assault victimization, which has implications for prevention and intervention efforts. This document is copyrighted by the American Psychological Association or one of its allied publishers. This article is intended solely for the personal use of the individual user and is not to be disseminated broadly. KW - sexual assault victimization KW - depression KW - sexual self-esteem KW - longitudinal study KW - Germany Y1 - 2016 U6 - https://doi.org/10.1037/tra0000198 SN - 1942-9681 SN - 1942-969X VL - 9 IS - 2 SP - 147 EP - 155 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Mohandesan, Elmira A1 - Speller, Camilla F. A1 - Peters, Joris A1 - Uerpmann, Hans-Peter A1 - Uerpmann, Margarethe A1 - De Cupere, Bea A1 - Hofreiter, Michael A1 - Burger, Pamela A. T1 - Combined hybridization capture and shotgun sequencing for ancient DNA analysis of extinct wild and domestic dromedary camel JF - Molecular ecology resources N2 - The performance of hybridization capture combined with next-generation sequencing (NGS) has seen limited investigation with samples from hot and arid regions until now. We applied hybridization capture and shotgun sequencing to recover DNA sequences from bone specimens of ancient-domestic dromedary (Camelus dromedarius) and its extinct ancestor, the wild dromedary from Jordan, Syria, Turkey and the Arabian Peninsula, respectively. Our results show that hybridization capture increased the percentage of mitochondrial DNA (mtDNA) recovery by an average 187-fold and in some cases yielded virtually complete mitochondrial (mt) genomes at multifold coverage in a single capture experiment. Furthermore, we tested the effect of hybridization temperature and time by using a touchdown approach on a limited number of samples. We observed no significant difference in the number of unique dromedary mtDNA reads retrieved with the standard capture compared to the touchdown method. In total, we obtained 14 partial mitochondrial genomes from ancient-domestic dromedaries with 17-95% length coverage and 1.27-47.1-fold read depths for the covered regions. Using whole-genome shotgun sequencing, we successfully recovered endogenous dromedary nuclear DNA (nuDNA) from domestic and wild dromedary specimens with 1-1.06-fold read depths for covered regions. Our results highlight that despite recent methodological advances, obtaining ancient DNA (aDNA) from specimens recovered from hot, arid environments is still problematic. Hybridization protocols require specific optimization, and samples at the limit of DNA preservation need multiple replications of DNA extraction and hybridization capture as has been shown previously for Middle Pleistocene specimens. KW - ancient DNA KW - Camelus dromedarius KW - capture enrichment KW - degraded DNA KW - mitochondrial genome (mtDNA) KW - next-generation sequencing Y1 - 2017 U6 - https://doi.org/10.1111/1755-0998.12551 SN - 1755-098X SN - 1755-0998 VL - 17 IS - 2 SP - 300 EP - 313 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Groschwitz, Jonas A1 - Szabo, Tibor T1 - Sharp Thresholds for Half-Random Games II JF - GRAPHS AND COMBINATORICS N2 - We study biased Maker-Breaker positional games between two players, one of whom is playing randomly against an opponent with an optimal strategy. In this work we focus on the case of Breaker playing randomly and Maker being "clever". The reverse scenario is treated in a separate paper. We determine the sharp threshold bias of classical games played on the edge set of the complete graph , such as connectivity, perfect matching, Hamiltonicity, and minimum degree-1 and -2. In all of these games, the threshold is equal to the trivial upper bound implied by the number of edges needed for Maker to occupy a winning set. Moreover, we show that CleverMaker can not only win against asymptotically optimal bias, but can do so very fast, wasting only logarithmically many moves (while the winning set sizes are linear in n). KW - Positional games KW - Randomized strategy KW - Sharp threshold KW - Fast win KW - Hamiltonicity KW - Connectivity Y1 - 2017 U6 - https://doi.org/10.1007/s00373-016-1753-4 SN - 0911-0119 SN - 1435-5914 VL - 33 SP - 387 EP - 401 PB - Springer CY - Tokyo ER - TY - JOUR A1 - Tanski, George A1 - Lantuit, Hugues A1 - Ruttor, Saskia A1 - Knoblauch, Christian A1 - Radosavljevic, Boris A1 - Strauß, Jens A1 - Wolter, Juliane A1 - Irrgang, Anna Maria A1 - Ramage, Justine Lucille A1 - Fritz, Michael T1 - Transformation of terrestrial organic matter along thermokarst-affected permafrost coasts in the Arctic JF - The science of the total environment : an international journal for scientific research into the environment and its relationship with man N2 - The changing climate in the Arctic has a profound impact on permafrost coasts, which are subject to intensified thermokarst formation and erosion. Consequently, terrestrial organic matter (OM) is mobilized and transported into the nearshore zone. Yet, little is known about the fate of mobilized OM before and after entering the ocean. In this study we investigated a retrogressive thaw slump (RTS) on Qikiqtaruk - Herschel Island (Yukon coast, Canada). The RTS was classified into an undisturbed, a disturbed (thermokarst-affected) and a nearshore zone and sampled systematically along transects. Samples were analyzed for total and dissolved organic carbon and nitrogen (TOC, DOC, TN, DN), stable carbon isotopes (delta C-13-TOC, delta C-13-DOC), and dissolved inorganic nitrogen (DIN), which were compared between the zones. C/N-ratios, delta C-13 signatures, and ammonium (NH4-N) concentrations were used as indicators for OM degradation along with biomarkers (n-alkanes, n-fatty adds, n-alcohols). Our results show that OM significantly decreases after disturbance with a TOC and DOC loss of 77 and 55% and a TN and DN loss of 53 and 48%, respectively. C/N-ratios decrease significantly, whereas NH4-N concentrations slightly increase in freshly thawed material. In the nearshore zone, OM contents are comparable to the disturbed zone. We suggest that the strong decrease in OM is caused by initial dilution with melted massive ice and immediate offshore transport via the thaw stream. In the mudpool and thaw stream, OM is subject to degradation, whereas in the slump floor the nitrogen decrease is caused by recolonizing vegetation. Within the nearshore zone of the ocean, heavier portions of OM are directly buried in marine sediments close to shore. We conclude that RTS have profound impacts on coastal environments in the Arctic. They mobilize nutrients from permafrost, substantially decrease OM contents and provide fresh water and nutrients at a point source. KW - Canadian Arctic KW - Coastal erosion KW - Retrogressive thaw slump KW - Biogeochemistry KW - Carbon degradation Y1 - 2017 U6 - https://doi.org/10.1016/j.scitotenv.2016.12.152 SN - 0048-9697 SN - 1879-1026 VL - 581 SP - 434 EP - 447 PB - Elsevier Science CY - Amsterdam ER - TY - JOUR A1 - Kuhlmann, Stella A1 - Tschorn, Mira A1 - Arolt, Volker A1 - Beer, Katja A1 - Brandt, Julia A1 - Grosse, Laura A1 - Haverkamp, Wilhelm A1 - Müller-Nordhorn, Jacqueline A1 - Rieckmann, Nina A1 - Waltenberger, Johannes A1 - Warnke, Katharina A1 - Hellweg, Rainer A1 - Ströhle, Andreas T1 - Serum brain-derived neurotrophic factor and stability of depressive symptoms in coronary heart disease patients BT - a prospective study JF - Psychoneuroendocrinology : an international journal ; the official journal of the International Society of Psychoneuroendocrinology N2 - Objective: Brain-derived neurotrophic factor (BDNF) supports neurogenesis, angiogenesis, and promotes the survival of various cell types in the brain and the coronary system. Moreover, BDNF is associated with both coronary heart disease (CHD) and depression. The current study aims to investigate whether serum BDNF levels are associated with the course of depressive symptoms in CHD patients. Methods: At baseline, N = 225 CHD patients were enrolled while hospitalized. Of these, N = 190 (84%) could be followed up 6 months later. Depressive symptoms were assessed both at baseline and at the 6-months follow-up using the Patient Health Questionnaire (PHQ-9). Serum BDNF concentrations were measured using fluorometric Enzyme-linked immunosorbent assays (ELISA). Results: Logistic regression models showed that lower BDNF levels were associated with persistent depressive symptoms, even after adjustment for age, sex, smoking and potential medical confounders. The incidence of depressive symptoms was not related to lower BDNF levels. However, somatic comorbidity (as measured by the Charlson Comorbidity Index) was significantly associated with the incidence of depressive symptoms. Conclusions: Our findings suggest a role of BDNF in the link between CHD and depressive symptoms. Particularly, low serum BDNF levels could be considered as a valuable biomarker for the persistence of depressive symptoms among depressed CHD patients. KW - Brain-derived neurotrophic factor (BDNF) KW - Coronary heart disease (CHD) KW - Depression KW - Serum Y1 - 2016 U6 - https://doi.org/10.1016/j.psyneuen.2016.12.015 SN - 0306-4530 VL - 77 SP - 196 EP - 202 PB - Elsevier Science CY - Oxford ER - TY - JOUR A1 - Lah, Ljerka A1 - Löber, Ulrike A1 - Hsiang, Tom A1 - Hartmann, Stefanie T1 - A genomic comparison of putative pathogenicity-related gene families in five members of the Ophiostomatales with different lifestyles JF - Fungal biology N2 - Ophiostomatoid fungi are vectored by their bark-beetle associates and colonize different host tree species. To survive and proliferate in the host, they have evolved mechanisms for detoxification and elimination of host defence compounds, efficient nutrient sequestration, and, in pathogenic species, virulence towards plants. Here, we assembled a draft genome of the spruce pathogen Ophiostoma bicolor. For our comparative and phylogenetic analyses, we mined the genomes of closely related species (Ophiostoma piceae, Ophiostoma ulmi, Ophiostoma novo-ulmi, and Grosmannia clavigera). Our aim was to acquire a genomic and evolutionary perspective of gene families important in host colonization. Genome comparisons showed that both the nuclear and mitochondrial genomes in our assembly were largely complete. Our O. bicolor 25.3 Mbp draft genome had 10 018 predicted genes, 6041 proteins with gene ontology (GO) annotation, 269 carbohydrate-active enzymes (CAZymes), 559 peptidases and inhibitors, and 1373 genes likely involved in pathogen-host interactions. Phylogenetic analyses of selected protein families revealed core sets of cytochrome P450 genes, ABC transporters and backbone genes involved in secondary metabolite (SM) biosynthesis (polyketide synthases (PKS) and non-ribosomal synthases), and species-specific gene losses and duplications. Phylogenetic analyses of protein families of interest provided insight into evolutionary adaptations to host biochemistry in ophiostomatoid fungi. KW - Bark beetle KW - Bluestain fungi KW - Ips typographus Y1 - 2016 U6 - https://doi.org/10.1016/j.funbio.2016.12.002 SN - 1878-6146 SN - 1878-6162 VL - 121 SP - 234 EP - 252 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Lindauer, Marius A1 - Hoos, Holger A1 - Leyton-Brown, Kevin A1 - Schaub, Torsten T1 - Automatic construction of parallel portfolios via algorithm configuration JF - Artificial intelligence N2 - Since 2004, increases in computational power described by Moore's law have substantially been realized in the form of additional cores rather than through faster clock speeds. To make effective use of modern hardware when solving hard computational problems, it is therefore necessary to employ parallel solution strategies. In this work, we demonstrate how effective parallel solvers for propositional satisfiability (SAT), one of the most widely studied NP-complete problems, can be produced automatically from any existing sequential, highly parametric SAT solver. Our Automatic Construction of Parallel Portfolios (ACPP) approach uses an automatic algorithm configuration procedure to identify a set of configurations that perform well when executed in parallel. Applied to two prominent SAT solvers, Lingeling and clasp, our ACPP procedure identified 8-core solvers that significantly outperformed their sequential counterparts on a diverse set of instances from the application and hard combinatorial category of the 2012 SAT Challenge. We further extended our ACPP approach to produce parallel portfolio solvers consisting of several different solvers by combining their configuration spaces. Applied to the component solvers of the 2012 SAT Challenge gold medal winning SAT Solver pfolioUZK, our ACPP procedures produced a significantly better-performing parallel SAT solver. KW - Algorithm configuration KW - Parallel SAT solving KW - Algorithm portfolios KW - Programming by optimization KW - Automated parallelization Y1 - 2016 U6 - https://doi.org/10.1016/j.artint.2016.05.004 SN - 0004-3702 SN - 1872-7921 VL - 244 SP - 272 EP - 290 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Zacharias, Michael A1 - Chen, Xuhui A1 - Wagner, Stefan T1 - Attenuation of TeV gamma-rays by the starlight photon field of the host galaxy JF - Monthly notices of the Royal Astronomical Society N2 - The absorption of TeV gamma-ray photons produced in relativistic jets by surrounding soft photon fields is a long-standing problem of jet physics. In some cases, the most likely emission site close to the central black hole is ruled out because of the high opacity caused by strong optical and infrared photon sources, such as the broad-line region. Mostly neglected for jet modelling is the absorption of gamma-rays in the starlight photon field of the host galaxy. Analysing the absorption for arbitrary locations and observation angles of the gamma-ray emission site within the host galaxy, we find that the distance to the galaxy centre, the observation angle, and the distribution of starlight in the galaxy are crucial for the amount of absorption. We derive the absorption value for a sample of 20 TeV-detected blazars with a redshift z(r) < 0.2. The absorption value of the gamma-ray emission located in the galaxy centre may be as high as 20 per cent, with an average value of 6 per cent. This is important in order to determine the intrinsic blazar parameters. We see no significant trends in our sample between the degree of absorption and host properties, such as starlight emissivity, galactic size, half-light radius, and redshift. While the uncertainty of the spectral properties of the extragalactic background light exceeds the effect of absorption by stellar light from the host galaxy in distant objects, the latter is a dominant effect in nearby sources. It may also be revealed in a differential comparison of sources with similar redshifts. KW - opacity KW - radiation mechanisms: non-thermal KW - galaxies: active KW - gamma-rays: galaxies Y1 - 2016 U6 - https://doi.org/10.1093/mnras/stw3032 SN - 0035-8711 SN - 1365-2966 VL - 465 IS - 3 SP - 3767 EP - 3774 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Fandrich, Artur A1 - Buller, Jens A1 - Memczak, Henry A1 - Stoecklein, W. A1 - Hinrichs, K. A1 - Wischerhoff, E. A1 - Schulz, B. A1 - Laschewsky, André A1 - Lisdat, Fred T1 - Responsive Polymer-Electrode Interface-Study of its Thermo- and pH-Sensitivity and the Influence of Peptide Coupling JF - Electrochimica acta : the journal of the International Society of Electrochemistry (ISE) N2 - This study introduces a thermally responsive, polymer-based electrode system. The key component is a surface-attached, temperature-responsive poly(oligoethylene glycol) methacrylate (poly(OEGMA)) type polymer bearing photoreactive benzophenone and carboxy groups containing side chains. The responsive behavior of the polymer in aqueous media has been investigated by turbidimetry measurements. Polymer films are formed on gold substrates by means of the photoreactive 2(dicyclohexylphosphino)benzophenone (DPBP) through photocrosslinking. The electrochemical behavior of the resulting polymer-substrate interface has been investigated in buffered [Fe(CN)6](3-)/[Fe (CN)6](4-)solutions at room temperature and under temperature variation by cyclic voltammetry (CV). The CV experiments show that with increasing temperature structural changes of the polymer layer occur, which alter the output of the electrochemical measurement. Repeated heating/cooling cycles analyzed by CV measurements and pH changes analyzed by quartz crystal microbalance with dissipation monitoring (QCM-D) reveal the reversible nature of the restructuring process. The immobilized films are further modified by covalent coupling of two small biomolecules - a hydrophobic peptide and a more hydrophilic one. These attached components influence the hydrophobicity of the layer in a different way the resulting change of the temperature-caused behavior has been studied by CV indicating a different state of the polymer after coupling of the hydrophobic peptide. KW - Stimuli-responsive materials KW - electroanalysis KW - modified electrode KW - bioreceptors KW - peptides KW - surface modification KW - cyclic voltammetry KW - IR ellipsometry KW - quartz crystal microbalance Y1 - 2017 U6 - https://doi.org/10.1016/j.electacta.2017.01.080 SN - 0013-4686 SN - 1873-3859 VL - 229 SP - 325 EP - 333 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Liebeck, Bernd Michael A1 - Hidalgo, Natalia A1 - Roth, Georg A1 - Popescu, Crisan A1 - Böker, Alexander T1 - Synthesis and characterization of Methyl Cellulose/Keratin Hydrolysate Composite Membranes JF - Polymers / Molecular Diversity Preservation International N2 - It is known that aqueous keratin hydrolysate solutions can be produced from feathers using superheated water as solvent. This method is optimized in this study by varying the time and temperature of the heat treatment in order to obtain a high solute content in the solution. With the dissolved polypeptides, films are produced using methyl cellulose as supporting material. Thereby, novel composite membranes are produced from bio-waste. It is expected that these materials exhibit both protein and polysaccharide properties. The influence of the embedded keratin hydrolysates on the methyl cellulose structure is investigated using Fourier transform infrared spectroscopy (FTIR) and wide angle X-ray diffraction (WAXD). Adsorption peaks of both components are present in the spectra of the membranes, while the X-ray analysis shows that the polypeptides are incorporated into the semi-crystalline methyl cellulose structure. This behavior significantly influences the mechanical properties of the composite films as is shown by tensile tests. Since further processing steps, e.g., crosslinking, may involve a heat treatment, thermogravimetric analysis (TGA) is applied to obtain information on the thermal stability of the composite materials. KW - bio-based KW - composite materials KW - methyl cellulose KW - keratin KW - superheated water Y1 - 2017 U6 - https://doi.org/10.3390/polym9030091 SN - 2073-4360 VL - 9 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kang, Mi-Sun A1 - Lim, Hae-Soon A1 - Oh, Jong-Suk A1 - Lim, You-jin A1 - Wuertz-Kozak, Karin A1 - Harro, Janette M. A1 - Shirtliff, Mark E. A1 - Achermann, Yvonne T1 - Antimicrobial activity of Lactobacillus salivarius and Lactobacillus fermentum against Staphylococcus aureus JF - Pathogens and disease / Federation of European Microbiology Societies N2 - The increasing prevalence of methicillin-resistant Staphylococcus aureus has become a major public health threat. While lactobacilli were recently found useful in combating various pathogens, limited data exist on their therapeutic potential for S. aureus infections. The aim of this study was to determine whether Lactobacillus salivarius was able to produce bactericidal activities against S. aureus and to determine whether the inhibition was due to a generalized reduction in pH or due to secreted Lactobacillus product(s). We found an 8.6-log10 reduction of planktonic and a 6.3-log10 reduction of biofilm S. aureus. In contrast, the previously described anti-staphylococcal effects of L. fermentum only caused a 4.0-log10 reduction in planktonic S. aureus cells, with no effect on biofilm S. aureus cells. Killing of S. aureus was partially pH dependent, but independent of nutrient depletion. Cell-free supernatant that was pH neutralized and heat inactivated or proteinase K treated had significantly reduced killing of L. salivarius than with pH-neutralized supernatant alone. Proteomic analysis of the L. salivarius secretome identified a total of five secreted proteins including a LysM-containing peptidoglycan binding protein and a protein peptidase M23B. These proteins may represent potential novel anti-staphylococcal agents that could be effective against S. aureus biofilms. KW - antibacterial activity KW - biofilm KW - Lactobacillus fermentum KW - Lactobacillus salivarius KW - LysM KW - Staphylococcus aureus Y1 - 2017 U6 - https://doi.org/10.1093/femspd/ftx009 SN - 2049-632X VL - 75 IS - 2 PB - Oxford Univ. Press CY - Oxford ER - TY - GEN A1 - Paycha, Sylvie T1 - Interview with Pierre Cartier BT - Potsdam, December 4th, 2014 T2 - The mathematical intelligencer Y1 - 2016 U6 - https://doi.org/10.1007/s00283-016-9673-y SN - 0343-6993 SN - 1866-7414 VL - 39 SP - 15 EP - 21 PB - Springer CY - New York ER - TY - JOUR A1 - Kröner, A. A1 - Alexeiev, D. V. A1 - Kovach, V. P. A1 - Rojas-Agramonte, Y. A1 - Tretyakov, A. A. A1 - Mikolaichuk, A. V. A1 - Xie, H. A1 - Sobel, Edward T1 - Zircon ages, geochemistry and Nd isotopic systematics for the Palaeoproterozoic 2.3-1.8 Ga Kuilyu Complex, East Kyrgyzstan BT - the oldest continental basement fragment in the Tianshan orogenic belt JF - Journal of Asian earth sciences N2 - Precambrian microcontinents represent key tectonic units in the accretionary collages of the western Central Asian Orogenic Belt (CAOB), and their geological history is reasonably well established since the Mesoproterozoic but remains weakly constrained for older epochs due to a scarcity of exposed Palaeoproterozoic and Archaean rocks. Early Precambrian rocks were previously reported from several metamorphic complexes in the Kyrgyz Tianshan orogenic belt, mainly based on multigrain conventional zircon dating, but the present study only confirmed such rocks at one site, namely in the Kuilyu Complex of eastern Kyrgyzstan. New single grain SHRIMP II zircon ages, geochemical data, and whole-rock Nd isotopic compositions for granitoid gneisses of the Kuilyu Complex elucidate the age, origin and tectonic settings of this oldest continental fragment in the Tianshan. The Kuilyu Complex is part of the basement in the Ishim - Middle Tianshan microcontinent. It consist of a strongly deformed and metamorphosed supracrustal assemblage of paragneisses and schists which are tectonically interlayered with amphibolites, migmatites and granitoid gneisses. Our zircon dating indicates that the Kuilyu Complex contains two suites of Palaeoproterozoic granitoid gneisses with magmatic protolith ages of ca. 2.32-2.33 Ga and 1.85 Ga. Granitoid magmatism at 1.85 Ga was almost immediately followed by amphibolite-facies metamorphism at ca 1.83 Ga, evidenced by growth of metamorphic zircon rims. The older, ca 2.3 Ga granitoid gneisses chemically correspond to calc-alkaline, metaluminous, I-type magnesian quartz diorite and granodiorite. The protolith of the younger, ca. 1.85 Ga granite-gneiss is an alkalic-calcic, metaluminous to peraluminous, ferroan medium-grained porphyric granite with chemical features resembling A-type granites. The 2.3 Ga and 1.85 Ga granitoid gneisses have slightly to distinctly negative initial epsilon(Nd) values of -1.2 and -6.6, and similar depleted mantle Nd model ages of 2.7-2.6 Ga, which imply melting of Neoarchaean continental crust. The zircon age patterns of the Kuilyu Complex resemble those of exposed rocks in the Tarim Craton, where episodes of granitoid magmatism at ca. 2.3-2.4 and 1.85 Ga, followed by amphibolite-facies metamorphism at ca 1.85 Ga, are also recorded. Similarities in the early Precambrian magmatic and metamorphic episodes as well as similar histories during the Neoproterozoic and early Palaeozoic suggest that the Ishim-Middle Tianshan microcontinent was rifted off the Tarim Craton. Similar age patterns also suggest possible tectonic links of the Kuilyu and Tarim continental blocks with the Baidrag Block of central Mongolia. In contrast, substantial differences in age and Precambrian evolution between the Anrakhai block of southern Kazakhstan and the Kuilyu Complex argue against a previous connection and suggest the former to represent an independent continental terrane. Current data show that early Precambrian rocks in the western CAOB outside Tarim only occur at two sites, namely in the Anrakhai Complex of southern Kazakhstan and in the Kuilyu Complex of eastern Kyrgyzstan. (C) 2016 Elsevier Ltd. All rights reserved. KW - Kuilyu Complex KW - Zircon dating KW - Microcontinent KW - CAOB KW - Middle Tianshan KW - Kyrgyzstan Y1 - 2017 U6 - https://doi.org/10.1016/j.jseaes.2016.12.022 SN - 1367-9120 SN - 1878-5786 VL - 135 SP - 122 EP - 135 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Civitillo, Sauro A1 - Schachner, Maja Katharina A1 - Juang, Linda P. A1 - van de Vijver, Fons J. R. A1 - Handrick, Anna A1 - Noack, Peter T1 - Towards a better understanding of cultural diversity approaches at school BT - a multi-informant and mixed-methods study JF - Learning, Culture and Social Interaction N2 - The current study investigates two types of cultural diversity approaches at school, namely (1) fostering equality and (2) promoting cultural pluralism. Adopting a mixed-methods design, this study assesses teachers' (n = 207) and students' (n = 1,644) self-reported perceptions of descriptive norms and evaluates school practices and artefacts in the physical and virtual environment of 22 secondary schools in south-west Germany. Results showed that in all schools under investigation teachers and students perceived descriptive norms fostering mostly equality. A wide variety of practices and artefacts was found, revealing a third distinct cultural approach leaning towards endorsing the majority culture. Different practices and artefacts were linked to an emphasis on equality, cultural pluralism, and endorsing the majority culture. Implications for educational policy, as well as applied diversity research, are discussed. KW - Cultural diversity KW - School KW - Equality KW - Pluralism KW - Mixed-methods Y1 - 2017 U6 - https://doi.org/10.1016/j.lcsi.2016.09.002 SN - 2210-6561 VL - 12 SP - 1 EP - 14 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Chaouachi, Mehdi A1 - Granacher, Urs A1 - Makhlouf, Issam A1 - Hammami, Raouf A1 - Behm, David G. A1 - Chaouachi, Anis T1 - Within Session Sequence of Balance and Plyometric Exercises Does Not Affect Training Adaptations with Youth Soccer Athletes JF - Journal of sports science & medicine N2 - The integration of balance and plyometric training has been shown to provide significant improvements in sprint, jump, agility, and other performance measures in young athletes. It is not known if a specific within session balance and plyometric exercise sequence provides more effective training adaptations. The objective of the present study was to investigate the effects of using a sequence of alternating pairs of exercises versus a block (series) of all balance exercises followed by a block of plyometric exercises on components of physical fitness such as muscle strength, power, speed, agility, and balance. Twenty-six male adolescent soccer players ( 13.9 +/- 0.3 years) participated in an 8-week training program that either alternated individual balance (e. g., exercises on unstable surfaces) and plyometric (e. g., jumps, hops, rebounds) exercises or performed a block of balance exercises prior to a block of plyometric exercises within each training session. Pre- and post-training measures included proxies of strength, power, agility, sprint, and balance such as countermovement jumps, isometric back and knee extension strength, standing long jump, 10 and 30-m sprints, agility, standing stork, and Y-balance tests. Both groups exhibited significant, generally large magnitude (effect sizes) training improvements for all measures with mean performance increases of approximately > 30%. There were no significant differences between the training groups over time. The results demonstrate the effectiveness of combining balance and plyometric exercises within a training session on components of physical fitness with young adolescents. The improved performance outcomes were not significantly influenced by the within session exercise sequence. KW - Power KW - strength KW - jumps KW - sprints KW - balance KW - children Y1 - 2017 SN - 1303-2968 VL - 16 SP - 125 EP - 136 PB - Department of Sports Medicine, Medical Faculty of Uludag University CY - Bursa ER - TY - JOUR A1 - Martinez-Valdes, Eduardo Andrés A1 - Negro, F. A1 - Laine, C. M. A1 - Falla, D. A1 - Mayer, Frank A1 - Farina, Dario T1 - Tracking motor units longitudinally across experimental sessions with high-density surface electromyography JF - The Journal of Physiology N2 - A new method is proposed for tracking individual motor units (MUs) across multiple experimental sessions on different days. The technique is based on a novel decomposition approach for high-density surface electromyography and was tested with two experimental studies for reliability and sensitivity. Experiment I (reliability): ten participants performed isometric knee extensions at 10, 30, 50 and 70% of their maximum voluntary contraction (MVC) force in three sessions, each separated by 1 week. Experiment II (sensitivity): seven participants performed 2 weeks of endurance training (cycling) and were tested pre-post intervention during isometric knee extensions at 10 and 30% MVC. The reliability (Experiment I) and sensitivity (Experiment II) of the measured MU properties were compared for the MUs tracked across sessions, with respect to all MUs identified in each session. In Experiment I, on average 38.3% and 40.1% of the identified MUs could be tracked across two sessions (1 and 2 weeks apart), for the vastus medialis and vastus lateralis, respectively. Moreover, the properties of the tracked MUs were more reliable across sessions than those of the full set of identified MUs (intra-class correlation coefficients ranged between 0.63-0.99 and 0.39-0.95, respectively). In Experiment II, similar to 40% of the MUs could be tracked before and after the training intervention and training-induced changes in MU conduction velocity had an effect size of 2.1 (tracked MUs) and 1.5 (group of all identified motor units). These results show the possibility of monitoring MU properties longitudinally to document the effect of interventions or the progression of neuromuscular disorders. Y1 - 2016 U6 - https://doi.org/10.1113/JP273662 SN - 0022-3751 SN - 1469-7793 VL - 595 SP - 1479 EP - 1496 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Schmidt, Bernd A1 - Riemer, Martin T1 - Microwave-Promoted Pd-Catalyzed Synthesis of Dibenzofurans from Ortho-Arylphenols JF - Journal of Heterocyclic Chemistry N2 - ortho-Aryl phenols, synthesized via protecting group free Suzuki-Miyaura coupling of ortho-halophenols and arene boronic acids, undergo a cyclization to dibenzofurans via oxidative C-H activation. The reaction proceeds under microwave irradiation in short reaction times using catalytic amounts of Pd(OAc)(2) without additional ligands. Y1 - 2017 U6 - https://doi.org/10.1002/jhet.2704 SN - 0022-152X SN - 1943-5193 VL - 54 IS - 2 SP - 1287 EP - 1297 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Nagel, Rebecca A1 - Kirschbaum, Frank A1 - Tiedemann, Ralph T1 - Electric organ discharge diversification in mormyrid weakly electric fish is associated with differential expression of voltage-gated ion channel genes JF - Journal of comparative physiology : A, Neuroethology, sensory, neural, and behavioral physiology N2 - In mormyrid weakly electric fish, the electric organ discharge (EOD) is used for species recognition, orientation and prey localization. Produced in the muscle-derived adult electric organ, the EOD exhibits a wide diversity across species in both waveform and duration. While certain defining EOD characteristics can be linked to anatomical features of the electric organ, many factors underlying EOD differentiation are yet unknown. Here, we report the differential expression of 13 Kv1 voltage-gated potassium channel genes, two inwardly rectifying potassium channel genes, two previously studied sodium channel genes and an ATPase pump in two sympatric species of the genus Campylomormyrus in both the adult electric organ and skeletal muscle. Campylomormyrus compressirostris displays a basal EOD, largely unchanged during development, while C. tshokwe has an elongated, putatively derived discharge. We report an upregulation in all Kv1 genes in the electric organ of Campylomormyrus tshokwe when compared to both skeletal muscle and C. compressirostris electric organ. This pattern of upregulation in a species with a derived EOD form suggests that voltage-gated potassium channels are potentially involved in the diversification of the EOD signal among mormyrid weakly electric fish. KW - Weakly electric fish KW - Ion channels KW - Electric organ KW - Gene expression KW - Campylomormyrus Y1 - 2017 U6 - https://doi.org/10.1007/s00359-017-1151-2 SN - 0340-7594 SN - 1432-1351 VL - 203 SP - 183 EP - 195 PB - Springer CY - New York ER - TY - JOUR A1 - Jessen, Anna A1 - Fleischhauer, Elisabeth A1 - Clahsen, Harald T1 - Morphological encoding in German children's language production BT - evidence from event-related brain potentials JF - Journal of child language N2 - This study reports developmental changes in morphological encoding across late childhood. We examined event-related brain potentials (ERPs) during the silent production of regularly vs. irregularly inflected verb forms (viz. -t vs. -n participles of German) in groups of eight- to ten-year-olds, eleven- to thirteen-year-olds, and adults. The adult data revealed an enhanced (right-frontal) negativity 300–450 ms after cue onset for the (silent) production of -t relative to -n past participle forms (e.g. geplant vs. gehauen ‘planned’ vs. ‘hit’). For the eleven- to thirteen-year-olds, the same enhanced negativity was found, with a more posterior distribution and a longer duration (=300–550 ms). The eight- to ten-year-olds also showed this negativity, again with a posterior distribution, but with a considerably delayed onset (800–1,000 ms). We suggest that this negativity reflects combinatorial processing required for producing -t participles in both children and adults and that the spatial and temporal modulations of this ERP effect across the three participant groups are due to developmental changes of the brain networks involved in processing morphologically complex words. Y1 - 2016 U6 - https://doi.org/10.1017/S0305000916000118 SN - 0305-0009 SN - 1469-7602 VL - 44 SP - 427 EP - 456 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Wiese, Heike A1 - Mayr, Katharina A1 - Krämer, Philipp A1 - Seeger, Patrick A1 - Müller, Hans-Georg A1 - Mezger, Verena T1 - Changing teachers' attitudes towards linguistic diversity BT - effects of an anti-bias programme JF - International Journal of Applied Linguistics N2 - We discuss an intervention programme for kindergarten and school teachers' continuing education in Germany that targets biases against language outside a perceived monolingual ‘standard’ and its speakers. The programme combines anti-bias methods relating to linguistic diversity with objectives of raising critical language awareness. Evaluation through teachers' workshops in Berlin and Brandenburg points to positive and enduring attitudinal changes in participants, but not in control groups that did not attend workshops, and effects were independent of personal variables gender and teaching subject and only weakly associated with age. We relate these effects to such programme features as indirect and inclusive methods that foster active engagement, and the combination of ‘safer’ topics targeting attitudes towards linguistic structures with more challenging ones dealing with the discrimination of speakers. N2 - Der Beitrag diskutiert ein Interventionsprogramm fur die Weiterbildung von Lehrer/inne/n und Erzieher/inne/n, das Vorurteile gegenuber sprachlichen Praktiken au ss erhalb eines vermeintlichen monolingualen Standarddeutschen und seinen Sprecher/inne/n fokussiert (). Das Programm verbindet Anti-bias -Methoden zur sprachlichen Vielfalt mit solchen, die auf eine Verstarkung kritischer Sprachbewusstheit abheben. Die Evaluation der Materialien in Lehrerfortbildungen in Berlin und Brandenburg weist auf positive und anhaltende Einstellungsveranderungen bei den Teilnehmer/inne/n, aber nicht bei Mitgliedern einer Kontrollgruppe, die nicht an den Fortbildungen teilnahm; die Effekte waren unabhangig von den personenbezogen Variablen Geschlecht und Lehrfach und nur schwach mit Alter assoziiert. Wir diskutieren diese Effekte im Zusammenhang mit Eigenschaften des Programms wie der Verwendung indirekter und inklusiver Methoden, die eine aktive Auseinandersetzung fordern, und der Verbindung von weniger bedrohlichen Themen, die sich auf Einstellungen gegenuber sprachlichen Strukturen beziehen, mit solchen, die die Diskrimierung von Sprecher/inne/n behandeln und daher eine gro ss ere Herausforderung darstellen KW - anti-bias KW - critical language awareness KW - language and education in multilingual settings KW - language attitudes KW - linguistic discrimination Y1 - 2017 U6 - https://doi.org/10.1111/ijal.12121 SN - 0802-6106 SN - 1473-4192 VL - 27 IS - 1 SP - 198 EP - 220 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Bremer, Anne A1 - Wolff, Martin A1 - Thalhammer, Anja A1 - Hincha, Dirk K. T1 - Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes JF - The FEBS journal N2 - Late embryogenesis abundant (LEA) proteins are related to cellular dehydration tolerance. Most LEA proteins are predicted to have no stable secondary structure in solution, i.e., to be intrinsically disordered proteins (IDPs), but they may acquire alpha-helical structure upon drying. In the model plant Arabidopsis thaliana, the LEA proteins COR15A and COR15B are highly induced upon cold treatment and are necessary for the plants to attain full freezing tolerance. Freezing leads to increased intracellular crowding due to dehydration by extracellular ice crystals. In vitro, crowding by high glycerol concentrations induced partial folding of COR15 proteins. Here, we have extended these investigations to two related proteins, LEA11 and LEA25. LEA25 is much longer than LEA11 and COR15A, but shares a conserved central sequence domain with the other two proteins. We have created two truncated versions of LEA25 (2H and 4H) to elucidate the structural and functional significance of this domain. Light scattering and CD spectroscopy showed that all five proteins were largely unstructured and monomeric in dilute solution. They folded in the presence of increasing concentrations of trifluoroethanol and glycerol. Additional folding was observed in the presence of glycerol and membranes. Fourier transform infra red spectroscopy revealed an interaction of the LEA proteins with membranes in the dry state leading to a depression in the gel to liquid-crystalline phase transition temperature. Liposome stability assays revealed a cryoprotective function of the proteins. The C- and N-terminal extensions of LEA25 were important in cryoprotection, as the central domain itself (2H, 4H) only provided a low level of protection. KW - intrinsically disordered proteins KW - late embryogenesis abundant proteins KW - osmolytes KW - protein folding KW - protein-membrane interaction Y1 - 2017 U6 - https://doi.org/10.1111/febs.14023 SN - 1742-464X SN - 1742-4658 VL - 284 SP - 919 EP - 936 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Edenius, Lars A1 - Choi, Chang-Yong A1 - Heim, Wieland A1 - Jaakkonen, Tuomo A1 - De Jong, Adriaan A1 - Ozaki, Kiyoaki A1 - Roberge, Jean-Michel T1 - The next common and widespread bunting to go? BT - global population decline in the Rustic Bunting Emberiza rustica JF - Bird conservation international N2 - Populations of several long-distance migratory songbirds in Eurasia are in peril, drastically illustrated by the recent range-wide population collapse in the Yellow-breasted Bunting Emberiza aureola. There are signals of a strong decline also in the Rustic Bunting E. rustica, but no range-wide assessment of population trends in this superabundant and widespread bunting species has yet been undertaken. The conservation status of Rustic Bunting is ‘Least Concern’ on the global IUCN Red List, but it has recently been upgraded to ‘Vulnerable’ on the European Red List. To assess the Rustic Bunting’s global conservation status we compiled, for the first time, population data across its breeding and wintering ranges. The analysis reveals a 75–87% decline in overall population size over the last 30 years and a 32–91% decline over the last 10 years. The trend estimates indicate that the long-term (30-year) range-wide population decline in the Rustic Bunting is of similar magnitude to two well-known examples of declining species within the same genus, the Yellow-breasted Bunting and the Ortolan Bunting E. hortulana. The magnitude of the range-wide population decline over the last 10 years suggests that the Rustic Bunting could be upgraded from ‘Least Concern’ to ‘Vulnerable’ or ‘Endangered’ on the IUCN global Red List. Agricultural intensification in the wintering range and intensified levels of disturbance, including logging and fire, in the breeding range could be important drivers of the range-wide population decline, and persecution could also contribute. Untangling threat factors and their interactions on Rustic Bunting is necessary for conservation, but hampered by our currently limited understanding of the relationships between population dynamics and different threats. Y1 - 2016 U6 - https://doi.org/10.1017/S0959270916000046 SN - 0959-2709 SN - 1474-0001 VL - 27 IS - 1 SP - 35 EP - 44 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Schöller, Markus A1 - Hubrig, Swetlana A1 - Fossati, L. A1 - Carroll, Thorsten Anthony A1 - Briquet, Maryline A1 - Oskinova, Lidia M. A1 - Järvinen, S. A1 - Ilyin, Ilya A1 - Castro, N. A1 - Morel, T. A1 - Langer, N. A1 - Przybilla, N. A1 - Nieva, M. -F. A1 - Kholtygin, A. F. A1 - Sana, H. A1 - Herrero, A. A1 - Barba, R. H. A1 - de Koter, A. T1 - B fields in OB stars (BOB) BT - Concluding the FORS2 observing campaign JF - Astronomy and astrophysics : an international weekly journal N2 - Aims. The B fields in OB stars (BOB) Collaboration is based on an ESO Large Programme to study the occurrence rate, properties, and ultimately the origin of magnetic fields in massive stars. Methods. In the framework of this program, we carried out low-resolution spectropolarimetric observations of a large sample of massive stars using FORS2 installed at the ESO VLT 8m telescope. Results. We determined the magnetic field values with two completely independent reduction and analysis pipelines. Our in-depth study of the magnetic field measurements shows that differences between our two pipelines are usually well within 3 sigma errors. From the 32 observations of 28 OB stars, we were able to monitor the magnetic fields in CPD -57 degrees 3509 and HD164492C, confirm the magnetic field in HD54879, and detect a magnetic field in CPD -62 degrees 2124. We obtain a magnetic field detection rate of 6 +/- 3% for the full sample of 69 OB stars observed with FORS 2 within the BOB program. For the preselected objects with a nu sin i below 60 km s(-1), we obtain a magnetic field detection rate of 5 +/- 5%. We also discuss X-ray properties and multiplicity of the objects in our FORS2 sample with respect to the magnetic field detections. KW - polarization KW - stars: early-type KW - stars: magnetic field KW - stars: massive Y1 - 2017 U6 - https://doi.org/10.1051/0004-6361/201628905 SN - 1432-0746 VL - 599 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Bogin, Barry A1 - Scheffler, Christiane A1 - Hermanussen, Michael T1 - Global effects of income and income inequality on adult height and sexual dimorphism in height JF - American journal of human biology : the official journal of the Human Biology Council N2 - Objectives: Average adult height of a population is considered a biomarker of the quality of the health environment and economic conditions. The causal relationships between height and income inequality are not well understood. We analyze data from 169 countries for national average heights of men and women and national-level economic factors to test two hypotheses: (1) income inequality has a greater association with average adult height than does absolute income; and (2) neither income nor income inequality has an effect on sexual dimorphism in height. Methods: Average height data come from the NCD-RisC health risk factor collaboration. Economic indicators are derived from the World Bank data archive and include gross domestic product (GDP), Gross National Income per capita adjusted for personal purchasing power (GNI_ PPP), and income equality assessed by the Gini coefficient calculated by the Wagstaff method. Results: Hypothesis 1 is supported. Greater income equality is most predictive of average height for both sexes. GNI_ PPP explains a significant, but smaller, amount of the variation. National GDP has no association with height. Hypothesis 2 is rejected. With greater average adult height there is greater sexual dimorphism. Conclusions: Findings support a growing literature on the pernicious effects of inequality on growth in height and, by extension, on health. Gradients in height reflect gradients in social disadvantage. Inequality should be considered a pollutant that disempowers people from the resources needed for their own healthy growth and development and for the health and good growth of their children. Y1 - 2017 U6 - https://doi.org/10.1002/ajhb.22980 SN - 1042-0533 SN - 1520-6300 VL - 29 IS - 2 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Perscheid, Michael A1 - Siegmund, Benjamin A1 - Taeumel, Marcel A1 - Hirschfeld, Robert T1 - Studying the advancement in debugging practice of professional software developers JF - Software Quality Journal N2 - In 1997, Henry Lieberman stated that debugging is the dirty little secret of computer science. Since then, several promising debugging technologies have been developed such as back-in-time debuggers and automatic fault localization methods. However, the last study about the state-of-the-art in debugging is still more than 15 years old and so it is not clear whether these new approaches have been applied in practice or not. For that reason, we investigate the current state of debugging in a comprehensive study. First, we review the available literature and learn about current approaches and study results. Second, we observe several professional developers while debugging and interview them about their experiences. Third, we create a questionnaire that serves as the basis for a larger online debugging survey. Based on these results, we present new insights into debugging practice that help to suggest new directions for future research. KW - Debugging KW - Literature review KW - Field study KW - Online survey Y1 - 2016 U6 - https://doi.org/10.1007/s11219-015-9294-2 SN - 0963-9314 SN - 1573-1367 VL - 25 SP - 83 EP - 110 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Anielski, Alexander A1 - Barbosa Pfannes, Eva Katharina A1 - Beta, Carsten T1 - Adaptive microfluidic gradient generator for quantitative chemotaxis experiments JF - Review of scientific instruments : a monthly journal devoted to scientific instruments, apparatus, and techniques N2 - Chemotactic motion in a chemical gradient is an essential cellular function that controls many processes in the living world. For a better understanding and more detailed modelling of the underlying mechanisms of chemotaxis, quantitative investigations in controlled environments are needed. We developed a setup that allows us to separately address the dependencies of the chemotactic motion on the average background concentration and on the gradient steepness of the chemoattractant. In particular, both the background concentration and the gradient steepness can be kept constant at the position of the cell while it moves along in the gradient direction. This is achieved by generating a well-defined chemoattractant gradient using flow photolysis. In this approach, the chemoattractant is released by a light-induced reaction from a caged precursor in a microfluidic flow chamber upstream of the cell. The flow photolysis approach is combined with an automated real-time cell tracker that determines changes in the cell position and triggers movement of the microscope stage such that the cell motion is compensated and the cell remains at the same position in the gradient profile. The gradient profile can be either determined experimentally using a caged fluorescent dye or may be alternatively determined by numerical solutions of the corresponding physical model. To demonstrate the function of this adaptive microfluidic gradient generator, we compare the chemotactic motion of Dictyostelium discoideum cells in a static gradient and in a gradient that adapts to the position of the moving cell. Published by AIP Publishing. Y1 - 2017 U6 - https://doi.org/10.1063/1.4978535 SN - 0034-6748 SN - 1089-7623 VL - 88 PB - American Institute of Physics CY - Melville ER - TY - JOUR A1 - Muñoz, Alfonso A1 - Mangano, Silvina A1 - Paz Gonzalez-Garcia, Mary A1 - Contreras, Ramon A1 - Sauer, Michael A1 - De Rybel, Bert A1 - Weijers, Dolf A1 - Juan Sanchez-Serrano, Jose A1 - Sanmartin, Maite A1 - Rojo, Enrique T1 - RIMA-Dependent Nuclear Accumulation of IYO Triggers Auxin-Irreversible Cell Differentiation in Arabidopsis JF - The plant cell N2 - The transcriptional regulator MINIYO (IYO) is essential and rate-limiting for initiating cell differentiation in Arabidopsis thaliana. Moreover, IYO moves from the cytosol into the nucleus in cells at the meristem periphery, possibly triggering their differentiation. However, the genetic mechanisms controlling IYO nuclear accumulation were unknown, and the evidence that increased nuclear IYO levels trigger differentiation remained correlative. Searching for IYO interactors, we identified RPAP2 IYO Mate (RIMA), a homolog of yeast and human proteins linked to nuclear import of selective cargo. Knockdown of RIMA causes delayed onset of cell differentiation, phenocopying the effects of IYO knockdown at the transcriptomic and developmental levels. Moreover, differentiation is completely blocked when IYO and RIMA activities are simultaneously reduced and is synergistically accelerated when IYO and RIMA are concurrently overexpressed, confirming their functional interaction. Indeed, RIMA knockdown reduces the nuclear levels of IYO and prevents its prodifferentiation activity, supporting the conclusion that RIMA-dependent nuclear IYO accumulation triggers cell differentiation in Arabidopsis. Importantly, by analyzing the effect of the IYO/RIMA pathway on xylem pole pericycle cells, we provide compelling evidence reinforcing the view that the capacity for de novo organogenesis and regeneration from mature plant tissues can reside in stem cell reservoirs. Y1 - 0201 U6 - https://doi.org/10.1105/tpc.16.00791 SN - 1040-4651 SN - 1532-298X VL - 29 IS - 3 SP - 575 EP - 588 PB - American Society of Plant Physiologists CY - Rockville ER - TY - JOUR A1 - Petrone, Caterina A1 - Truckenbrodt, Hubert A1 - Wellmann, Caroline A1 - Holzgrefe-Lang, Julia A1 - Wartenburger, Isabell A1 - Höhle, Barbara T1 - Prosodic boundary cues in German BT - evidence from the production and perception of bracketed lists JF - Journal of phonetics N2 - This study investigates prosodic phrasing of bracketed lists in German. We analyze variation in pauses, phrase-final lengthening and f0 in speech production and how these cues affect boundary perception. In line with the literature, it was found that pauses are often used to signal intonation phrase boundaries, while final lengthening and f0 are employed across different levels of the prosodic hierarchy. Deviations from expectations based on the standard syntax-prosody mapping are interpreted in terms of task-specific effects. That is, we argue that speakers add/delete prosodic boundaries to enhance the phonological contrast between different bracketings in the experimental task. In perception, three experiments were run, in which we tested only single cues (but temporally distributed at different locations of the sentences). Results from identification tasks and reaction time measurements indicate that pauses lead to a more abrupt shift in listeners׳ prosodic judgments, while f0 and final lengthening are exploited in a more gradient manner. Hence, pauses, final lengthening and f0 have an impact on boundary perception, though listeners show different sensitivity to the three acoustic cues. KW - Prosodic boundary KW - Phrase-final lengthening KW - Pause KW - f0 peaks KW - Production KW - Perception KW - German Y1 - 2017 U6 - https://doi.org/10.1016/j.wocn.2017.01.002 SN - 0095-4470 VL - 61 SP - 71 EP - 92 PB - Elsevier CY - London ER - TY - JOUR A1 - Elmas, Ali A1 - Koralay, Ersin A1 - Duru, Olgun A1 - Schmidt, Alexander T1 - Geochronology, geochemistry, and tectonic setting of the Oligocene magmatic rocks (Marmaros Magmatic Assemblage) in Gokceada Island, northwest Turkey JF - International Geology Review N2 - Through the zmir-Ankara-Erzincan and the Vardar oceans suture zones, convergence between the Eurasian and African plates played a key role in controlling Palaeogene magmatism in north-western Anatolia, northern Aegean, and eastern Balkans. LA-ICP-MS dating of U and Pb isotopes on zircon separates from the tuffs of the Harmankaya Volcanic Rocks, which are inter-fingered with the lower-middle Eocene deposits of the Gazikoy Formation to the north of the Ganos Fault and the Karaaac Formation in the Gelibolu Peninsula, yielded a late Ypresian (51Ma) age. The chemical characteristics suggest that the lavas and tuffs of the Harmankaya Volcanic Rocks are products of syn- or post-collision magmas. These volcanic rocks show also close affinities to the subduction-related magmas. In addition to the already known andesitic volcanic rocks, our field observations in Gokceada Island indicate also the existence of granitic and rhyolitic rocks (Marmaros Magmatic Assemblage). Our U-Pb zircon age data has shown that the newly discovered Marmaros granitic plutons intruded during late Oligocene (26Ma) into the deposits of the Karaaac Formation in Gokceada Island. LA-ICP-MS dating of U and Pb isotopes on zircon separates from the Marmaros rhyolitic rocks yielded a late Oligocene (26Ma) crystallization age. Geochemical characteristics indicate that the more-evolved Oligocene granitic and rhyolitic rock of the Marmaros Magmatic Assemblage possibly assimilated a greater amount of crustal material than the lower Eocene Harmankaya Volcanic Rocks. Geochemical features and age relationships suggest increasing amounts of crustal contamination and a decreasing subduction signature during the evolution of magmas in NW Turkey from the early Eocene to the Oligocene. The magmatic activity developed following the northward subduction of the zmir-Ankara-Erzincan oceanic lithosphere and the earliest Palaeocene final continental collision between the Sakarya and Anatolide-Tauride zones. KW - U-Pb geochronology KW - geochemistry KW - granitoids KW - rhyolites KW - post-collision KW - Eocene-Oligocene KW - Gokceada Island KW - Northwestern Turkey Y1 - 2016 U6 - https://doi.org/10.1080/00206814.2016.1227941 SN - 0020-6814 SN - 1938-2839 VL - 59 IS - 4 SP - 420 EP - 447 PB - Taylor & Francis Group CY - Philadelphia ER - TY - JOUR A1 - Meyners, Christian A1 - Mertens, Monique A1 - Wessig, Pablo A1 - Meyer-Almes, Franz-Josef T1 - A Fluorescence-Lifetime-Based Binding Assay for Class IIa Histone Deacetylases JF - Chemistry - a European journal N2 - Class IIa histone deacetylases (HDACs) show extremely low enzymatic activity and no commonly accepted endogenous substrate is known today. Increasing evidence suggests that these enzymes exert their effect rather through molecular recognition of acetylated proteins and recruiting other proteins like HDAC3 to the desired target location. Accordingly, class IIa HDACs like bromodomains have been suggested to act as “Readers” of acetyl marks, whereas enzymatically active HDACs of class I or IIb are called “Erasers” to highlight their capability to remove acetyl groups from acetylated histones or other proteins. Small-molecule ligands of class IIa histone deacetylases (HDACs) have gained tremendous attention during the last decade and have been suggested as pharmaceutical targets in several indication areas such as cancer, Huntington's disease and muscular atrophy. Up to now, only enzyme activity assays with artificial chemically activated trifluoroacetylated substrates are in use for the identification and characterization of new active compounds against class IIa HDACs. Here, we describe the first binding assay for this class of HDAC enzymes that involves a simple mix-and-measure procedure and an extraordinarily robust fluorescence lifetime readout based on [1,3]dioxolo[4,5-f]benzodioxole-based ligand probes. The principle of the assay is generic and can also be transferred to class I HDAC8. KW - drug discovery KW - enzymes KW - fluorescent probes KW - high-throughput screening KW - hydrolases Y1 - 2017 U6 - https://doi.org/10.1002/chem.201605140 SN - 0947-6539 SN - 1521-3765 VL - 23 IS - 13 SP - 3107 EP - 3116 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Wiemann, Dirk T1 - Indian Writing in English and the Discrepant Zones of World Literature JF - Anglia : journal of English philology N2 - For world literature studies, Indian writing in English offers an exceptionally rich and variegated field of analysis: On the one hand, a set of prominent Indian or diasporic writers accrues substantial literary capital through metropolitan review circuits and award systems and thus maintains the high international visibility that Indian writing in English has acquired ever since the early 1980s. Addressing a readership that spans countries and continents, this kind of writing functions as a viable tributary to world literature. On the other hand, a new boom of Indian mass fiction in English has emerged that, while targeting a strictly domestic audience, is always already implicated in the dynamics of world literature as well, albeit in a very different way: As they deploy, appropriate and adopt a wide range of globally available templates of popular genres, these texts have globality inscribed into their very textures even if they do not circulate internationally. Y1 - 2017 U6 - https://doi.org/10.1515/ang-2017-0008 SN - 0340-5222 SN - 1865-8938 VL - 135 IS - 1 SP - 122 EP - 139 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Plue, Jan A1 - De Frenne, Pieter A1 - Acharya, Kamal A1 - Brunet, Jörg A1 - Chabrerie, Olivier A1 - Decocq, Guillaume A1 - Diekmann, Martin A1 - Graae, Bente J. A1 - Heinken, Thilo A1 - Hermy, Martin A1 - Kolb, Annette A1 - Lemke, Isgard A1 - Liira, Jaan A1 - Naaf, Tobias A1 - Verheyen, Kris A1 - Wulf, Monika A1 - Cousins, Sara A. O. T1 - Where does the community start, and where does it end? BT - including the seed bank to reassess forest herb layer responses to the environment JF - Journal of vegetation science N2 - QuestionBelow-ground processes are key determinants of above-ground plant population and community dynamics. Still, our understanding of how environmental drivers shape plant communities is mostly based on above-ground diversity patterns, bypassing below-ground plant diversity stored in seed banks. As seed banks may shape above-ground plant communities, we question whether concurrently analysing the above- and below-ground species assemblages may potentially enhance our understanding of community responses to environmental variation. LocationTemperate deciduous forests along a 2000km latitudinal gradient in NW Europe. MethodsHerb layer, seed bank and local environmental data including soil pH, canopy cover, forest cover continuity and time since last canopy disturbance were collected in 129 temperate deciduous forest plots. We quantified herb layer and seed bank diversity per plot and evaluated how environmental variation structured community diversity in the herb layer, seed bank and the combined herb layer-seed bank community. ResultsSeed banks consistently held more plant species than the herb layer. How local plot diversity was partitioned across the herb layer and seed bank was mediated by environmental variation in drivers serving as proxies of light availability. The herb layer and seed bank contained an ever smaller and ever larger share of local diversity, respectively, as both canopy cover and time since last canopy disturbance decreased. Species richness and -diversity of the combined herb layer-seed bank community responded distinctly differently compared to the separate assemblages in response to environmental variation in, e.g. forest cover continuity and canopy cover. ConclusionsThe seed bank is a below-ground diversity reservoir of the herbaceous forest community, which interacts with the herb layer, although constrained by environmental variation in e.g. light availability. The herb layer and seed bank co-exist as a single community by means of the so-called storage effect, resulting in distinct responses to environmental variation not necessarily recorded in the individual herb layer or seed bank assemblages. Thus, concurrently analysing above- and below-ground diversity will improve our ecological understanding of how understorey plant communities respond to environmental variation. KW - Above-ground KW - Below-ground KW - Canopy KW - Disturbance KW - Diversity KW - Light availability KW - NWEurope KW - Plant community KW - Species co-existence KW - Storage effect Y1 - 2017 U6 - https://doi.org/10.1111/jvs.12493 SN - 1100-9233 SN - 1654-1103 VL - 28 IS - 2 SP - 424 EP - 435 PB - Wiley CY - Hoboken ER -