TY - JOUR A1 - Hartig, Olaf A1 - Pirrò, Giuseppe T1 - SPARQL with property paths on the Web JF - Semantic web N2 - Linked Data on the Web represents an immense source of knowledge suitable to be automatically processed and queried. In this respect, there are different approaches for Linked Data querying that differ on the degree of centralization adopted. On one hand, the SPARQL query language, originally defined for querying single datasets, has been enhanced with features to query federations of datasets; however, this attempt is not sufficient to cope with the distributed nature of data sources available as Linked Data. On the other hand, extensions or variations of SPARQL aim to find trade-offs between centralized and fully distributed querying. The idea is to partially move the computational load from the servers to the clients. Despite the variety and the relative merits of these approaches, as of today, there is no standard language for querying Linked Data on theWeb. A specific requirement for such a language to capture the distributed, graph-like nature of Linked Data sources on the Web is a support of graph navigation. Recently, SPARQL has been extended with a navigational feature called property paths (PPs). However, the semantics of SPARQL restricts the scope of navigation via PPs to single RDF graphs. This restriction limits the applicability of PPs for querying distributed Linked Data sources on the Web. To fill this gap, in this paper we provide formal foundations for evaluating PPs on the Web, thus contributing to the definition of a query language for Linked Data. We first introduce a family of reachability-based query semantics for PPs that distinguish between navigation on the Web and navigation at the data level. Thereafter, we consider another, alternative query semantics that couples Web graph navigation and data level navigation; we call it context-based semantics. Given these semantics, we find that for some PP-based SPARQL queries a complete evaluation on the Web is not possible. To study this phenomenon we introduce a notion of Web-safeness of queries, and prove a decidable syntactic property that enables systems to identify queries that areWeb-safe. In addition to establishing these formal foundations, we conducted an experimental comparison of the context-based semantics and a reachability- based semantics. Our experiments show that when evaluating a PP-based query under the context-based semantics one experiences a significantly smaller number of dereferencing operations, but the computed query result may contain less solutions. KW - Property paths KW - Web navigational language KW - Web safeness KW - SPARQL Y1 - 2017 U6 - https://doi.org/10.3233/SW-160237 SN - 1570-0844 SN - 2210-4968 VL - 8 IS - 6 SP - 773 EP - 795 PB - IOS Press CY - Amsterdam ER - TY - CHAP A1 - Kügler, Frank T1 - Tone and intonation in Akan T2 - Intonation in African Tone Languages N2 - This chapter provides an account of the intonation patterns in Akan (Kwa, Niger-Congo). Tonal processes such as downstep, tonal spreading and tonal replacement influence the surface tone pattern of a sentence. In general, any Akan utterance independent of sentence type shows a characteristic down-trend in pitch. This chapter proposes that Akan employs a simple post-lexical tonal grammar that accounts for the shapes of an intonation contour. The unmarked post-lexical structure is found in simple declaratives. The downward trend of an intonation contour is shaped by local tonal interactions (downstep), and sentence-final tonal neutralization. In polar questions, an iota-phrase-final low boundary tone (L%) accounts for the intensity increase and lengthening of the final vowel compared to a declarative. Complex declaratives and left-dislocations show a partial pitch reset at the left edge of an embedded iota-phrase. Underlying lexical tones are not affected by intonation with the exception of sentence-final H-tones. KW - downstep KW - low boundary tone KW - polar question KW - constituent question KW - imperative KW - complex declarative KW - Akan KW - pitch register reset KW - prosodic phrasing KW - tonal neutralization KW - avoidance KW - lax question prosody Y1 - 2017 SN - 978-3-11-050352-4; 978-3-11-048479-3 U6 - https://doi.org/10.1515/9783110503524-004 SN - 1861-4191 VL - 24 SP - 89 EP - 129 PB - De Gruyter Mouton CY - Berlin ER - TY - GEN A1 - Gronau, Norbert A1 - Ullrich, André A1 - Teichmann, Malte T1 - Development of the industrial IoT competences in the areas of organization, process, and interaction based on the learning factory concept T2 - Procedia manufacturing N2 - Lately, first implementation approaches of Internet of Things (IoT) technologies penetrate industrial value-adding processes. Within this, the competence requirements for employees are changing. Employees’ organization, process, and interaction competences are of crucial importance in this new IoT environment, however, in students and vocational training not sufficiently considered yet. On the other hand, conventional learning factories evolve and transform to digital learning factories. Nevertheless, the integration of IoT technology and its usage for training in digital learning factories has been largely neglected thus far. Existing learning factories do not explicitly and properly consider IoT technology, which leads to deficiencies regarding an appropriate development of employees’ Industrial IoT competences. The goal of this contribution is to point out a didactic concept that enables development and training of these new demanded competences by using an IoT laboratory. For this purpose, a design science approach is applied. The result of this contribution is a didactic concept for the development of Industrial IoT competences in an IoT laboratory. KW - Digital Learning Factory KW - Industrial IoT Competences KW - Student Training KW - Vocational Training Y1 - 2017 U6 - https://doi.org/10.1016/j.promfg.2017.04.029 SN - 2351-9789 VL - 9 SP - 254 EP - 261 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Paramonov, Guennaddi K. A1 - Kühn, Oliver A1 - Bandrauk, André D. T1 - Excitation of H+ 2 with one-cycle laser pulses BT - shaped post-laser-field electronic oscillations, generation of higher- and lower-order harmonics JF - Molecular physics : MP ; an international journal in the field of chemical physics N2 - Non-Born–Oppenheimer quantum dynamics of H+ 2 excited by shaped one-cycle laser pulses linearly polarised along the molecular axis have been studied by the numerical solution of the time-dependent Schrödinger equation within a three-dimensional model, including the internuclear separation, R, and the electron coordinates z and ρ. Laser carrier frequencies corresponding to the wavelengths λ l = 25 nm through λ l = 400 nm were used and the amplitudes of the pulses were chosen such that the energy of H+ 2 was close to its dissociation threshold at the end of any laser pulse applied. It is shown that there exists a characteristic oscillation frequency ωosc ≃ 0.2265 au (corresponding to the period of τosc ≃ 0.671 fs and the wavelength of λosc ≃ 201 nm) that manifests itself as a ‘carrier’ frequency of temporally shaped oscillations of the time-dependent expectation values ⟨z ⟩ and ⟨∂V/∂z ⟩ that emerge at the ends of the laser pulses and exist on a timescale of at least 50 fs. Time-dependent expectation values ⟨ρ⟩ and ⟨∂V /∂ρ⟩ of the optically passive degree of freedom, ρ, demonstrate post-laser-field oscillations at two basic frequencies ωρ 1 ≈ ωosc and ωρ 2 ≈ 2ωosc. Power spectra associated with the electronic motion show higher- and lower-order harmonics with respect to the driving field. KW - One-cycle laser pulses KW - post-laser-field electronic oscillations KW - generation of higher and lower harmonics Y1 - 2017 U6 - https://doi.org/10.1080/00268976.2017.1288938 SN - 0026-8976 SN - 1362-3028 VL - 115 IS - 15/16 SP - 1846 EP - 1860 PB - Taylor & Francis CY - London ER - TY - JOUR A1 - Wiemers, Michael A1 - Bekkering, Harold A1 - Lindemann, Oliver T1 - Is more always up? BT - evidence for a preference of hand-based associations over vertical number mappings JF - Journal of cognitive psychology N2 - It has been argued that the association of numbers and vertical space plays a fundamental role for the understanding of numerical concepts. However, convincing evidence for an association of numbers and vertical bimanual responses is still lacking. The present study tests the vertical Spatio-Numerical-Association-of-Response-Codes (SNARC) effect in a number classification task by comparing anatomical hand-based and spatial associations. A mixed effects model of linear spatial-numerical associations revealed no evidence for a vertical but clear support for an anatomical SNARC effect. Only if the task requirements prevented participants from using a number-hand association due to frequently alternating hand-to-button assignments, numbers were associated with the vertical dimension. Taken together, the present findings question the importance of vertical associations for the conceptual understanding of numerical magnitude as hypothesised by some embodied approaches to number cognition and suggest a preference for ego-over geocentric reference frames for the mapping of numbers onto space. KW - SNARC effect KW - embodied numerosity KW - numerical cognition Y1 - 2017 U6 - https://doi.org/10.1080/20445911.2017.1302451 SN - 2044-5911 SN - 2044-592X VL - 29 IS - 5 SP - 642 EP - 652 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Richter, Philipp ED - Fox, Andrew J. ED - Davé, Romeel T1 - Gas accretion onto the Milky Way JF - Astrophysics and space science library N2 - The Milky Way is surrounded by large amounts of gaseous matter that are slowly being accreted over cosmic timescales to support star formation in the disk. The corresponding gas-accretion rate represents a key parameter for the past, present, and future evolution of the Milky Way. In this chapter, we discuss our current understanding of gas accretion processes in the Galaxy by reviewing past and recent observational and theoretical studies. The first part of this review deals with the spatial distribution of the different gas phases in the Milky Way halo, the origin of the gas, and its total mass. The second part discusses the gas dynamics and the physical processes that regulate the gas flow from the outer Galactic halo to the disk. From the most recent studies follows that the present-day gas accretion rate of the Milky Way is a few solar masses per year, which is sufficient to maintain the Galaxy’s star-formation rate at its current level. Y1 - 2017 SN - 978-3-319-52512-9 SN - 978-3-319-52511-2 U6 - https://doi.org/10.1007/978-3-319-52512-9_2 SN - 0067-0057 VL - 430 SP - 15 EP - 47 PB - Springer CY - Cham ER - TY - GEN A1 - Kay, Alex James T1 - Disagreement is fine. Misrepresentation is not BT - response to John Morello T2 - The international history review Y1 - 2017 U6 - https://doi.org/10.1080/07075332.2017.1354547 SN - 0707-5332 SN - 1949-6540 VL - 39 SP - 929 EP - 930 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - GEN A1 - Giese, Holger ED - Kouchnarenko, Olga ED - Khosravi, Ramtin T1 - Formal models and analysis for self-adaptive cyber-physical systems BT - (extended abstract) T2 - Lecture notes in computer science N2 - In this extended abstract, we will analyze the current challenges for the envisioned Self-Adaptive CPS. In addition, we will outline our results to approach these challenges with SMARTSOS [10] a generic approach based on extensions of graph transformation systems employing open and adaptive collaborations and models at runtime for trustworthy self-adaptation, self-organization, and evolution of the individual systems and the system-of-systems level taking the independent development, operation, management, and evolution of these systems into account. Y1 - 2017 SN - 978-3-319-57666-4 SN - 978-3-319-57665-7 U6 - https://doi.org/10.1007/978-3-319-57666-4_1 SN - 0302-9743 SN - 1611-3349 VL - 10231 SP - 3 EP - 9 PB - Springer CY - Cham ER - TY - GEN A1 - Serth, Sebastian A1 - Podlesny, Nikolai A1 - Bornstein, Marvin A1 - Lindemann, Jan A1 - Latt, Johanna A1 - Selke, Jan A1 - Schlosser, Rainer A1 - Boissier, Martin A1 - Uflacker, Matthias T1 - An interactive platform to simulate dynamic pricing competition on online marketplaces T2 - 2017 IEEE 21st International Enterprise Distributed Object Computing Conference (EDOC) N2 - E-commerce marketplaces are highly dynamic with constant competition. While this competition is challenging for many merchants, it also provides plenty of opportunities, e.g., by allowing them to automatically adjust prices in order to react to changing market situations. For practitioners however, testing automated pricing strategies is time-consuming and potentially hazardously when done in production. Researchers, on the other side, struggle to study how pricing strategies interact under heavy competition. As a consequence, we built an open continuous time framework to simulate dynamic pricing competition called Price Wars. The microservice-based architecture provides a scalable platform for large competitions with dozens of merchants and a large random stream of consumers. Our platform stores each event in a distributed log. This allows to provide different performance measures enabling users to compare profit and revenue of various repricing strategies in real-time. For researchers, price trajectories are shown which ease evaluating mutual price reactions of competing strategies. Furthermore, merchants can access historical marketplace data and apply machine learning. By providing a set of customizable, artificial merchants, users can easily simulate both simple rule-based strategies as well as sophisticated data-driven strategies using demand learning to optimize their pricing strategies. Y1 - 2017 SN - 978-1-5090-3045-3 U6 - https://doi.org/10.1109/EDOC.2017.17 SN - 2325-6354 SP - 61 EP - 66 PB - Institute of Electrical and Electronics Engineers CY - New York ER - TY - JOUR A1 - Seiffert, Martin A1 - Holstein, Flavio A1 - Schlosser, Rainer A1 - Schiller, Jochen T1 - Next generation cooperative wearables BT - generalized activity assessment computed fully distributed with in a wireless body area network JF - IEEE access : practical research, open solutions N2 - Currently available wearables are usually based on a single sensor node with integrated capabilities for classifying different activities. The next generation of cooperative wearables could be able to identify not only activities, but also to evaluate them qualitatively using the data of several sensor nodes attached to the body, to provide detailed feedback for the improvement of the execution. Especially within the application domains of sports and health-care, such immediate feedback to the execution of body movements is crucial for (re-) learning and improving motor skills. To enable such systems for a broad range of activities, generalized approaches for human motion assessment within sensor networks are required. In this paper, we present a generalized trainable activity assessment chain (AAC) for the online assessment of periodic human activity within a wireless body area network. AAC evaluates the execution of separate movements of a prior trained activity on a fine-grained quality scale. We connect qualitative assessment with human knowledge by projecting the AAC on the hierarchical decomposition of motion performed by the human body as well as establishing the assessment on a kinematic evaluation of biomechanically distinct motion fragments. We evaluate AAC in a real-world setting and show that AAC successfully delimits the movements of correctly performed activity from faulty executions and provides detailed reasons for the activity assessment. KW - Body sensor networks KW - distributed computing KW - motion analysis KW - physical activity assessment KW - biomechanics KW - multilevel systems Y1 - 2017 U6 - https://doi.org/10.1109/ACCESS.2017.2749005 SN - 2169-3536 VL - 5 SP - 16793 EP - 16807 PB - Institute of Electrical and Electronics Engineers CY - Piscataway ER - TY - GEN A1 - Low, Thomas A1 - Hentschel, Christian A1 - Stober, Sebastian A1 - Sack, Harald A1 - Nürnberger, Andreas ED - Amsaleg, Laurent ED - Guðmundsson, Gylfi Þór ED - Gurrin, Cathal ED - Jónsson, Björn Þór ED - Satoh, Shin'ichi T1 - Exploring large movie collections BT - comparing visual berrypicking and traditional browsing T2 - Lecture notes in computer science N2 - We compare Visual Berrypicking, an interactive approach allowing users to explore large and highly faceted information spaces using similarity-based two-dimensional maps, with traditional browsing techniques. For large datasets, current projection methods used to generate maplike overviews suffer from increased computational costs and a loss of accuracy resulting in inconsistent visualizations. We propose to interactively align inexpensive small maps, showing local neighborhoods only, which ideally creates the impression of panning a large map. For evaluation, we designed a web-based prototype for movie exploration and compared it to the web interface of The Movie Database (TMDb) in an online user study. Results suggest that users are able to effectively explore large movie collections by hopping from one neighborhood to the next. Additionally, due to the projection of movie similarities, interesting links between movies can be found more easily, and thus, compared to browsing serendipitous discoveries are more likely. KW - Exploratory interfaces KW - Media retrieval KW - Multidimensional scaling KW - User study Y1 - 2016 SN - 978-3-319-51814-5 SN - 978-3-319-51813-8 U6 - https://doi.org/10.1007/978-3-319-51814-5_17 SN - 0302-9743 SN - 1611-3349 VL - 10133 SP - 198 EP - 208 PB - Springer CY - Cham ER - TY - JOUR A1 - Wieczorek, Mareike A1 - Kolmogorov, Alexei A1 - Kruse, Stefan A1 - Jacobsen, Inga A1 - Nitze, Ingmar A1 - Nikolaev, Anatoly N. A1 - Heinrich, Ingo A1 - Pestryakova, Luidmila Agafyevna A1 - Herzschuh, Ulrike T1 - Disturbance-effects on treeline larch-stands in the lower Kolyma River area (NE Siberia) JF - Silva Fennica : a quarterly journal for forest science N2 - Tree stands in the boreal treeline ecotone are, in addition to climate change, impacted by disturbances such as fire, water-related disturbances and logging. We aim to understand how these disturbances affect growth, age structure, and spatial patterns of larch stands in the north-eastern Siberian treeline ecotone (lower Kolyma River region), an insufficiently researched region. Stand structure of Larix cajanderi Mayr was studied at seven sites impacted by disturbances. Maximum tree age ranged from 44 to 300 years. Young to medium-aged stands had, independent of disturbance type, the highest stand densities with over 4000 larch trees per ha. These sites also had the highest growth rates for tree height and stem diameter. Overall lowest stand densities were found in a polygonal field at the northern end of the study area, with larches growing in distinct " tree islands". At all sites, saplings are significantly clustered. Differences in fire severity led to contrasting stand structures with respect to tree, recruit, and overall stand densities. While a low severity fire resulted in low-density stands with high proportions of small and young larches, high severity fires resulted in high-density stands with high proportions of big trees. At waterdisturbed sites, stand structure varied between waterlogged and drained sites and latitude. These mixed effects of climate and disturbance make it difficult to predict future stand characteristics and the treeline position. KW - treeline KW - Larix cajanderi KW - Siberia KW - fire KW - stand structure Y1 - 2017 U6 - https://doi.org/10.14214/sf.1666 SN - 0037-5330 SN - 2242-4075 VL - 51 IS - 3 PB - The Finnish Society of Forest Science CY - Helsinki ER - TY - GEN A1 - Fraschetti, Federico A1 - Pohl, Martin T1 - Two-zone model for the broadband crab nebula spectrum BT - microscopic interpretation T2 - The European physical journal : Web of Conferences : proceedings N2 - We develop a simple two-zone interpretation of the broadband baseline Crab nebula spectrum between 10(-5) eV and similar to 100 TeV by using two distinct log-parabola energetic electrons distributions. We determine analytically the very-high energy photon spectrum as originated by inverse-Compton scattering of the far-infrared soft ambient photons within the nebula off a first population of electrons energized at the nebula termination shock. The broad and flat 200 GeV peak jointly observed by Fermi/LAT and MAGIC is naturally reproduced. The synchrotron radiation from a second energetic electron population explains the spectrum from the radio range up to similar to 10 keV. We infer from observations the energy dependence of the microscopic probability of remaining in proximity of the shock of the accelerating electrons. Y1 - 2017 U6 - https://doi.org/10.1051/epjconf/201713602009 SN - 2100-014X VL - 136 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Hoehn, Richard S. A1 - Jernigan, Peter L. A1 - Japtok, Lukasz A1 - Chang, Alex L. A1 - Midura, Emily F. A1 - Caldwell, Charles C. A1 - Kleuser, Burkhard A1 - Lentsch, Alex B. A1 - Edwards, Michael J. A1 - Gulbins, Erich A1 - Pritts, Timothy A. T1 - Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflammation JF - Annals of surgery : a monthly review of surgical science and practice N2 - Objective: We aimed to identify the role of the enzyme acid sphingomyelinase in the aging of stored units of packed red blood cells (pRBCs) and subsequent lung inflammation after transfusion. Summary Background Data: Large volume pRBC transfusions are associated with multiple adverse clinical sequelae, including lung inflammation. Microparticles are formed in stored pRBCs over time and have been shown to contribute to lung inflammation after transfusion. Methods: Human and murine pRBCs were stored with or without amitriptyline, a functional inhibitor of acid sphingomyelinase, or obtained from acid sphingomyelinase-deficient mice, and lung inflammation was studied in mice receiving transfusions of pRBCs and microparticles isolated from these units. Results: Acid sphingomyelinase activity in pRBCs was associated with the formation of ceramide and the release of microparticles. Treatment of pRBCs with amitriptyline inhibited acid sphingomyelinase activity, ceramide accumulation, and microparticle production during pRBC storage. Transfusion of aged pRBCs or microparticles isolated from aged blood into mice caused lung inflammation. This was attenuated after transfusion of pRBCs treated with amitriptyline or from acid sphingomyelinase-deficient mice. Conclusions: Acid sphingomyelinase inhibition in stored pRBCs offers a novel mechanism for improving the quality of stored blood. KW - acid sphingomyelinase KW - blood banking KW - ceramide KW - lung inflammation KW - microparticle Y1 - 2017 U6 - https://doi.org/10.1097/SLA.0000000000001648 SN - 0003-4932 SN - 1528-1140 VL - 265 IS - 1 SP - 218 EP - 226 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Yang, Xiaoping A1 - Darko, Kwame Oteng A1 - Huang, Yanjun A1 - He, Caimei A1 - Yang, Huansheng A1 - He, Shanping A1 - Li, Jianzhong A1 - Li, Jian A1 - Hocher, Berthold A1 - Yin, Yulong T1 - Resistant starch regulates gut microbiota BT - structure, biochemistry and cell signalling JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology N2 - Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota. KW - Resistant starch KW - Gut microbiota KW - Nutrition Y1 - 2017 U6 - https://doi.org/10.1159/000477386 SN - 1015-8987 SN - 1421-9778 VL - 42 IS - 1 SP - 306 EP - 318 PB - Karger CY - Basel ER - TY - JOUR A1 - He, Jing A1 - Liu, Zhi-Wei A1 - Lu, Yong-Ping A1 - Li, Tao-Yuan A1 - Liang, Xu-Jing A1 - Arck, Petra A1 - Huang, Si-Min A1 - Hocher, Berthold A1 - Chen, You-Peng T1 - A systematic review and meta-analysis of influenza a virus infection during pregnancy associated with an increased risk for stillbirth and low birth weight JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. Methods: Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis. Data of included studies was extracted and analyzed by the RevMan software. Results: Pregnant women with anemia (P=0.004, RR=1.46, 95% CI: 1.13-1.88), obesity (P<0.00001, RR=1.35, 95% CI: 1.25-1.46) and asthma (P<0.00001, RR=1.99, 95% CI: 1.67-2.37) had higher rates of influenza virus infection. Regarding birth outcomes, influenza A virus infection did not affect the likelihood for cesarean section. Mothers with influenza had a higher rate of stillbirth (P=0.04, RR=2.36, 95% CI: 1.05-5.31), and their offspring had low 5-minute APGR Scores (P=0.009, RR=1.39, 95% CI: 1.08-1.79). Furthermore, the rate for birth weight < 2500g (P=0.04, RR=1.71, 95% CI: 1.03-2.84) was increased. Conclusion: Results of this study showed that anemia, asthma and obesity during pregnancy are risk factors influenza A virus infection during pregnancy. Moreover, gestational influenza A infection impairs pregnancy outcomes and increases the risk for low birth weight, a known risk factor for later life disease susceptibility. KW - Apgar score KW - Influenza virus KW - Offspring KW - Outcome KW - Pregnancy KW - Stillbirth KW - Birth weight Y1 - 2017 U6 - https://doi.org/10.1159/000477221 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 2 SP - 232 EP - 243 PB - Karger CY - Basel ER - TY - JOUR A1 - Reichetzeder, Christoph A1 - Heunisch, Fabian A1 - von Einem, Gina-Franziska A1 - Tsuprykov, Oleg A1 - Kellner, Karl-Heinz A1 - Dschietzig, Thomas A1 - Kretschmer, Axel A1 - Hocher, Berthold T1 - Pre-interventional kynurenine predicts medium-term outcome after contrast media exposure due to coronary angiography JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application. Methods: In this prospective cohort study 245 patients undergoing coronary angiography were analyzed. Blood samples were obtained at baseline, 24h and 48h after contrast media (CM) application to diagnose CI-AKI. Patients were followed for 120 days for adverse clinical events including death, the need for dialysis, and a doubling of plasma creatinine. Occurrence of any of these events was summarized in the combined endpoint MAKE. Results: Preinterventional plasma kynurenine was not associated with CI-AKI. Patients who later developed MAKE displayed significantly increased preinterventional plasma kynurenine levels (p<0.0001). ROC analysis revealed that preinterventional kynurenine is highly predictive for MAKE (AUC=0.838; p<0.0001). The optimal cutoff was found at >= 3.5 mu mol/L. Using this cutoff, the Kaplan-Meier estimator demonstrated that concentrations of plasma kynurenine >= 3.5 mu mol/L were significantly associated with a higher prevalence of MAKE until follow up (p<0.0001). This association remained significant in multivariate Cox regression models adjusted for relevant factors of long-term renal outcome. Conclusion: Preinterventional plasma kynurenine might serve as a highly predictive biomarker for MAKE up to 120 days after coronary angiography. KW - Contrast induced acute kidney injury KW - Coronary angiography KW - Major adverse kidney event KW - Kynurenine KW - Preinterventional biomarker Y1 - 2017 U6 - https://doi.org/10.1159/000477222 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 2 SP - 244 EP - 256 PB - Karger CY - Basel ER - TY - JOUR A1 - Xu, Mei A1 - Lu, Yong-Ping A1 - Hasan, Ahmed A. A1 - Hocher, Berthold T1 - Plasma ET-1 concentrations are elevated in patients with hypertension meta-analysis of clinical studies JF - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft N2 - Background/Aims: A recent study revealed that global overexpression of ET-1 causes a slight reduction in systemic blood pressure. Moreover, heterozygous ET-1 knockout mice are hypertensive. The role of ET-1 in human hypertension was so far not addressed by a strict meta-analysis of published human clinical studies. Methods: We included studies published between January 1, 1990 and February 28, 2017. We included case control studies analyzing untreated essential hypertension or hypertensive patients where antihypertensive medication was discontinued for at least two weeks. Based on the principle of Cochrane systematic reviews, case control studies (CCSs) in PubMed (Medline) and Google Scholar designed to identify the role of endothelin-1 (ET-1) in the pathophysiological of hypertension were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects models. Results: Eleven studies fulfilling our in-and exclusion criteria were eligible for this meta-analysis. These studies included 450 hypertensive patients and 328 controls. Our meta-analysis revealed that ET-1 plasma concentrations were higher in hypertensive patients as compared to the control patients [mean difference between groups 1.57 pg/mL, 95%Ci [0.47 similar to 2.68, P = 0.005]. These finding were driven by patients having systolic blood pressure higher than 160 mmHg and diastolic blood pressure higher than 100 mmHg. Conclusions: This meta-analysis showed that hypertensive patients do have elevated plasma ET-1 concentrations. This finding is driven by those patients with high systolic/diastolic blood pressure. Given that the ET-1 gene did not appear in any of the whole genome association studies searching for hypertension associated gene loci, it is very likely that the elevated plasma ET-1 concentrations in hypertensive patients are secondary to hypertension and may reflect endothelial cell damage. KW - Hypertension KW - ET-1 KW - Meta-analysis Y1 - 2017 U6 - https://doi.org/10.1159/000477572 SN - 1420-4096 SN - 1423-0143 VL - 42 IS - 2 SP - 304 EP - 313 PB - Karger CY - Basel ER - TY - JOUR A1 - Weck, Florian A1 - Witthöft, Michael T1 - Context effects in the evaluation of bodily symptoms BT - comparing three versions of the health norms sorting task JF - Journal of experimental psychopathology N2 - The illness-related evaluation of bodily symptoms is considered to be an important maintaining factor in somatoform disorders. However, little is known about context variables that could influence this evaluation process. In the current study, participants completed three versions of the Health Norms Sorting Task (HNST) and evaluated bodily symptoms in different contexts (i.e., different evaluation perspectives and time frames of evaluation). Additionally, the three HNST versions were presented in different orders. Bodily symptoms were evaluated more often as a sign of illness when a specific time frame (i.e., one week) was given. However, this context effect was only large when participants had previously evaluated symptoms existing without a concrete duration. Thus, previously completed symptom evaluations appear to represent an important frame of reference in terms of a cue that makes specific context variables salient. The results further suggested that these cueing effects might be less relevant for participants with elevated somatic symptom reports. KW - context effects KW - Health Norms Sorting Task KW - somatic symptom disorder KW - symptom evaluation Y1 - 2017 U6 - https://doi.org/10.5127/jep.054216 SN - 2043-8087 VL - 8 SP - 241 EP - 251 PB - Sage Publishing CY - London ER - TY - JOUR A1 - Omotosho, Adebayo A1 - Emuoyibofarhe, Justice A1 - Meinel, Christoph T1 - Securing e-prescription from medical identity theft using steganography and antiphishing techniques JF - Journal of applied security research N2 - Drug prescription is among the health care process that usually makes references to the patients’ medical and insurance information among other personal data, because this information is very vital and delicate, it should be adequately protected from identity thieves. This article aims at securing Electronic Prescription (EP) in order to minimize patient’s data theft and foster patients’ trust of EP system. This paper presents a steganography and antiphishing technique for preventing medical identity theft in EP. The proposed EP system design focused on the security features in the prescriber and dispensers’ modules of EP by ensuring the prescriber sends the prescription of the patient in a safe manner and to the right dispenser without the interference of fake third parties. Hexadecimal steganography image system is used to cover and secure the sent prescription details. Malicious electronic dispensing system is prevented through an authentication technique where a dispenser uses a captcha together with a one-time password, and the web server encrypted token for prescriber’s device authentication. The steganography system is evaluated using Peak Signal to Noise Ratio (PSNR). The system implementation results showed that steganography and antiphishing techniques are capable of providing a secure EP systems. KW - Electronic prescription KW - one-time password KW - steganography KW - phishing KW - medical identity theft Y1 - 2017 U6 - https://doi.org/10.1080/19361610.2017.1315788 SN - 1936-1610 SN - 1936-1629 VL - 12 SP - 447 EP - 461 PB - Routledge, Taylor & Francis Group CY - Philadelphia ER - TY - JOUR A1 - Wobbe, Theresa A1 - Renard, Léa A1 - Müller, Katja T1 - Nationale und globale Deutungsmodelle des Geschlechts im arbeitsstatistischen sowie arbeitsrechtlichen Klassifikationssystem BT - ein vergleichstheoretischer Beitrag (1882-1992) JF - Soziale Welt : SozW ; Zeitschrift für sozialwissenschaftliche Forschung und Praxis N2 - Dieser Beitrag beschäftigt sich mit der Frage, welche Relevanz arbeitsstatis-tische und -rechtliche Kategorisierungen im Zeitraum von 1880 bis 1992 für den Wandel der Deu-tungsmodelle des Geschlechts haben. Aus vergleichstheoretischer stellt die Durchsetzung desmodernen Konzepts der Erwerbsarbeit um 1900 im nationalen Kontext und dessen Veränderung aufglobaler Ebene ein spezifisches Ordnungsverfahren dar, das im Mittelpunkt dieses Aufsatzes steht.Auf der Grundlage von zwei Mikrostudien zur Klassifizierung und Reklassifizierung der „Mithel-fenden Familienangehörigen“ und des „Nachtarbeitsverbots“ wird zum einen die Globalisierung derErwerbsarbeit als Beobachtungsschema, zum anderen der Wandel des Deutungsmodells derGeschlechterdifferenz im Zuge transnationaler Vergleichsverfahren erforscht. In dem Beitrag wirddie Auffassung vertreten, dass der Vergleich einen Globalisierungsmechanismus in der Weltgesell-schaft darstellt. Y1 - 2017 U6 - https://doi.org/10.5771/0038-6073-2017-1-63 SN - 0038-6073 VL - 68 SP - 63 EP - 85 PB - Nomos-Verl.-Ges. CY - Baden-Baden ER - TY - JOUR A1 - Musalek, Martin A1 - Kokstejn, Jakub A1 - Papez, Pavel A1 - Scheffler, Christiane A1 - Mumm, Rebekka A1 - Czernitzki, Anna-Franziska A1 - Koziel, Slawomir T1 - Impact of normal weight obesity on fundamental motor skills in pre-school children aged 3 to 6 years JF - Journal of biological and clinical anthropology : Anthropologischer Anzeiger ; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Normal weight obesity is defined as having excessive body fat, but normal BMI. Even though previous research revealed that excessive body fat in children inhibited their physical activity and decreased motor performance, there has been only little evidence about motor performance of normal weight obese children. This study aims to establish whether normal weight obese pre-school children aged 3-6 years will have a significantly worse level of fundamental motor skills compared to normal weight non-obese counterparts. The research sample consisted of 152 pre-schoolers selected from a specific district of Prague, the Czech Republic. According to values from four skinfolds: triceps, subscapula, suprailiaca, calf, and BMI three categories of children aged 3-6 years were determined: A) normal weight obese n = 51; B) normal weight non-obese n = 52; C) overweight and obese n = 49. The Movement Assessment Battery for Children (MABC-2) was used for the assessment of fundamental motor skills. Normal weight obese children had significantly higher amount of adipose tissue p < 0.001 than normal weight non-obese children but the same average BMI. Moreover, normal weight obese children did not have significantly less amount of subcutaneous fat on triceps and calf compared to their overweight and obese peers. In majority of MABC-2 tests, normal weight obese pre-schoolers showed the poorest performance. Moreover, normal weight obese children had significantly worse total standard score = 38.82 compared to normal weight non-obese peers = 52.27; p < 0.05. In addition, normal weight obese children had a more than three times higher frequency OR = 3.69 CI95% (1.10; 12.35) of severe motor deficit performance <= 5th centile of the MABC-2 norm. These findings are strongly alarming since indices like BMI are not able to identify normal weight obese individual. We recommend verifying real portion of normal weight obese children as they are probably in higher risk of health and motor problems than overweight and obese population due to their low lean mass. KW - normal weight obesity KW - fundamental motor skills KW - MABC-2 KW - performance KW - pre-school children KW - skinfolds KW - adipose tissue KW - lean mass Y1 - 2017 U6 - https://doi.org/10.1127/anthranz/2017/0752 SN - 0003-5548 VL - 74 SP - 203 EP - 212 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Mera, Azal Jaafar Musa A1 - Tarchanov, Nikolaj Nikolaevič T1 - The Neumann Problem after Spencer JF - Žurnal Sibirskogo Federalʹnogo Universiteta = Journal of Siberian Federal University : Matematika i fizika = Mathematics & physics N2 - When trying to extend the Hodge theory for elliptic complexes on compact closed manifolds to the case of compact manifolds with boundary one is led to a boundary value problem for the Laplacian of the complex which is usually referred to as Neumann problem. We study the Neumann problem for a larger class of sequences of differential operators on a compact manifold with boundary. These are sequences of small curvature, i.e., bearing the property that the composition of any two neighbouring operators has order less than two. KW - elliptic complexes KW - manifolds with boundary KW - Hodge theory KW - Neumann problem Y1 - 2017 U6 - https://doi.org/10.17516/1997-1397-2017-10-4-474-493 SN - 1997-1397 SN - 2313-6022 VL - 10 SP - 474 EP - 493 PB - Sibirskij Federalʹnyj Universitet CY - Krasnojarsk ER - TY - JOUR A1 - Mumm, Rebekka A1 - Czernitzki, Anna-Franziska A1 - Bents, Dominik A1 - Musalek, Martin T1 - Socioeconomic situation and growth in infants and juveniles JF - Anthropologischer Anzeiger : journal of biological and clinical anthropology ; Mitteilungsorgan der Gesellschaft für Anthropologie N2 - Background: Physical growth of children and adolescents depends on the interaction of genetic and environmental factors e.g. diet and living conditions. Aim: We aim to discuss the influence of socioeconomic situation, using income inequality and GDP per capita as indicators, on body height, body weight and the variability of height and weight in infants and juveniles. Material and methods: We re-analyzed data from 439 growth studies on height and weight published during the last 35 years. We added year-and country-matched GDP per capita (in current US$) and the Gini coefficient for each study. The data were divided into two age groups: infants (age 2) and juveniles (age 7). We used Pearson correlation and principal component analysis to investigate the data. Results: Gini coefficient negatively correlated with body height and body weight in infants and juveniles. GDP per capita showed a positive correlation with height and weight in both age groups. In infants the standard deviation of height increases with increasing Gini coefficient. The opposite is true for juveniles. A correlation of weight variability and socioeconomic indicators is absent in infants. In juveniles the variability of weight increases with declining Gini coefficient and increasing logGDP per capita. Discussion: Poverty and income inequality are generally associated with poor growth in height and weight. The analysis of the within-population height and weight variations however, shows that the associations between wealth, income, and anthropometric parameters are very complex and cannot be explained by common wisdom. They point towards an independent regulation of height and weight. KW - socioeconomic situation KW - height KW - weight KW - variability KW - community effect Y1 - 2017 U6 - https://doi.org/10.1127/anthranz/2017/0706 SN - 0003-5548 VL - 74 SP - 101 EP - 107 PB - Schweizerbart CY - Stuttgart ER - TY - JOUR A1 - Morgner, Frank A1 - Bennemann, Mark A1 - Cywiński, Piotr J. A1 - Kollosche, Matthias A1 - Górski, Krzysztof A1 - Pietraszkiewicz, Marek A1 - Geßner, André A1 - Löhmannsröben, Hans-Gerd T1 - Elastic FRET sensors for contactless pressure measurement JF - RSC Advances : an international journal to further the chemical sciences N2 - Contactless pressure monitoring based on Forster resonance energy transfer between donor/acceptor pairs immobilized within elastomers is demonstrated. The donor/acceptor energy transfer is employed by dispersing terbium(III) tris[(2-hydroxybenzoyl)-2-aminoethyl] amine complex (LLC, donor) and CdSe/ZnS quantum dots (QD655, acceptor) in styrene-ethylene/buthylene-styrene (SEBS) and poly(dimethylsiloxane) (PDMS). The continuous monitoring of QD luminescence showed a reversible intensity change as the pressure signal is alternated between two stable states indicating a pressure sensitivity of 6350 cps kPa(-1). Time-resolved measurements show the pressure impact on the FRET signal due to an increase of decay time (270 ms up to 420 ms) for the donor signal and parallel drop of decay time (170 mu s to 155 mu s) for the acceptor signal as the net pressure applied. The LLC/QD655 sensors enable a contactless readout as well as space resolved monitoring to enable miniaturization towards smaller integrated stretchable opto-electronics. Elastic FRET sensors can potentially lead to developing profitable analysis systems capable to outdo conventional wired electronic systems (inductive, capacitive, ultrasonic and photoelectric sensors) especially for point-of-care diagnostics, biological monitoring required for wearable electronics. Y1 - 2017 U6 - https://doi.org/10.1039/c7ra06379b SN - 2046-2069 VL - 7 SP - 50578 EP - 50583 PB - RSC Publishing CY - Cambridge ER - TY - JOUR A1 - Hinz, Carsten ED - Banse, Gerhard ED - Apelojg, Benjamin T1 - Bildung für nachhaltige Entwicklung BT - von der Notwendigkeit einer Integration in die Lehrerbildung JF - Technische Bildung und berufliche Orientierung im Wandel- Rückblick, Einblicke, Ausblicke (Sitzungsberichte Leibniz-Sozietät der Wissenschaften) Y1 - 2017 UR - https://leibnizsozietaet.de/wp-content/uploads/2017/10/20-Carsten-Hinz.pdf VL - 133/134 SP - 167 EP - 175 PB - Trafo CY - Berlin ER - TY - GEN A1 - Renz, Jan A1 - Shams, Ahmed A1 - Meinel, Christoph T1 - Offline-Enabled Web-based E-Learning for Improved User Experience in Africa T2 - 2017 IEEE Africon N2 - Web-based E-Learning uses Internet technologies and digital media to deliver education content to learners. Many universities in recent years apply their capacity in producing Massive Open Online Courses (MOOCs). They have been offering MOOCs with an expectation of rendering a comprehensive online apprenticeship. Typically, an online content delivery process requires an Internet connection. However, access to the broadband has never been a readily available resource in many regions. In Africa, poor and no networks are yet predominantly experienced by Internet users, frequently causing offline each moment a digital device disconnect from a network. As a result, a learning process is always disrupted, delayed and terminated in such regions. This paper raises the concern of E-Learning in poor and low bandwidths, in fact, it highlights the needs for an Offline-Enabled mode. The paper also explores technical approaches beamed to enhance the user experience inWeb-based E-Learning, particular in Africa. KW - Educational Technology KW - E-Learning KW - Internet KW - Bandwidth KW - Mobile Learning KW - Mobiles KW - MOOC KW - Offline-Enabled KW - Ubiquitous Y1 - 2017 SN - 978-1-5386-2775-4 U6 - https://doi.org/10.1109/AFRCON.2017.8095574 SN - 2153-0025 SP - 736 EP - 742 PB - IEEE CY - New York ER - TY - JOUR A1 - Hornick, Thomas A1 - Bach, Lennart T. A1 - Crawfurd, Katharine J. A1 - Spilling, Kristian A1 - Achterberg, Eric P. A1 - Woodhouse, Jason Nicholas A1 - Schulz, Kai G. A1 - Brussaard, Corina P. D. A1 - Riebesell, Ulf A1 - Grossart, Hans-Peter T1 - Ocean acidification impacts bacteria-phytoplankton coupling at low-nutrient conditions JF - Biogeosciences N2 - The oceans absorb about a quarter of the annually produced anthropogenic atmospheric carbon dioxide (CO2), resulting in a decrease in surface water pH, a process termed ocean acidification (OA). Surprisingly little is known about how OA affects the physiology of heterotrophic bacteria or the coupling of heterotrophic bacteria to phytoplankton when nutrients are limited. Previous experiments were, for the most part, undertaken during productive phases or following nutrient additions designed to stimulate algal blooms. Therefore, we performed an in situ large-volume mesocosm (similar to 55 m(3)) experiment in the Baltic Sea by simulating different fugacities of CO2 (fCO(2)) extending from present to future conditions. The study was conducted in July-August after the nominal spring bloom, in order to maintain low-nutrient conditions throughout the experiment. This resulted in phytoplankton communities dominated by small-sized functional groups (picophytoplankton). There was no consistent fCO(2)-induced effect on bacterial protein production (BPP), cell-specific BPP (csBPP) or biovolumes (BVs) of either free-living (FL) or particle-associated (PA) heterotrophic bacteria, when considered as individual components (univariate analyses). Permutational Multivariate Analysis of Variance (PERMANOVA) revealed a significant effect of the fCO(2) treatment on entire assemblages of dissolved and particulate nutrients, metabolic parameters and the bacteria-phytoplankton community. However, distance-based linear modelling only identified fCO(2) as a factor explaining the variability observed amongst the microbial community composition, but not for explaining variability within the metabolic parameters. This suggests that fCO(2) impacts on microbial metabolic parameters occurred indirectly through varying physicochemical parameters and microbial species composition. Cluster analyses examining the co-occurrence of different functional groups of bacteria and phytoplankton further revealed a separation of the four fCO(2)-treated mesocosms from both control mesocosms, indicating that complex trophic interactions might be altered in a future acidified ocean. Possible consequences for nutrient cycling and carbon export are still largely unknown, in particular in a nutrient-limited ocean. Y1 - 2017 U6 - https://doi.org/10.5194/bg-14-1-2017 SN - 1726-4170 SN - 1726-4189 VL - 14 IS - 1 SP - 1 EP - 15 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Rätzel, Dennis A1 - Wilkens, Martin A1 - Menzel, Ralf T1 - Effect of polarization entanglement in photon-photon scattering JF - Physical review : A, Atomic, molecular, and optical physics N2 - It is found that the differential cross section of photon-photon scattering is a function of the degree of polarization entanglement of the two-photon state. A reduced general expression for the differential cross section of photon-photon scattering is derived by applying simple symmetry arguments. An explicit expression is obtained for the example of photon-photon scattering due to virtual electron-positron pairs in quantum electrodynamics. It is shown how the effect in this explicit example can be explained as an effect of quantum interference and that it fits with the idea of distance-dependent forces. Y1 - 2017 U6 - https://doi.org/10.1103/PhysRevA.95.012101 SN - 2469-9926 SN - 2469-9934 VL - 95 IS - 1 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Makhmudov, O. I. A1 - Tarchanov, Nikolaj Nikolaevič T1 - The first mixed problem for the nonstationary Lamé system JF - The Rocky Mountain journal of mathematics N2 - We find an adequate interpretation of the stationary Lam'{e} operator within the framework of elliptic complexes and study the first mixed problem for the nonstationary Lam'{e} system. KW - Lame system KW - evolution equation KW - first boundary value problem Y1 - 2018 U6 - https://doi.org/10.1216/RMJ-2017-47-8-2731 SN - 0035-7596 SN - 1945-3795 VL - 47 IS - 8 SP - 2731 EP - 2756 PB - Rocky Mountain Mathematics Consortium CY - Tempe ER - TY - JOUR A1 - Muwonge, Charles Magoba A1 - Schiefele, Ulrich A1 - Ssenyonga, Joseph A1 - Kibedi, Henry T1 - Determinants of persistence among science teacher-trainees BT - Examining the role of self-efficacy, task value, and academic hope JF - ournal of science teacher education : official journal of the Association for Science Teacher Education (ASTE) N2 - Grounded in the expectancy-value and hope theories, the present study was conducted to examine the extent to which self-efficacy, task value, and academic hope predict persistence among science teacher-trainees in Uganda. The sample consisted of 278 undergrad- uate science teacher-trainees selected from a large public university in northern Uganda. Data were collected using several scales from the modified Motivated Strategies for Learning Questionnaire, Academic Hope Scale, and College Persistence Questionnaire and analyzed using structural equation modeling. Task value and aca- demic hope significantly predicted students’ persistence. Academic hope made a greater contribution to students’ persistence compared to task value. The combined effect of task value and academic hope did not make any significant contribution to students’ persistence. The study highlights the need to strengthen students’ hopeful think- ing and task value in order to increase their chances of completing their studies. Implications of the study findings for educational practice and for the training of science teacher-trainees are elaborated in the article. KW - Academic hope KW - persistence KW - science teacher-trainees KW - self-efficacy KW - task value Y1 - 2017 U6 - https://doi.org/10.1080/1046560X.2017.1379860 SN - 1046-560X SN - 1573-1847 VL - 28 SP - 522 EP - 548 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Hoffmann, Mathias A1 - Schulz-Hanke, Maximilian A1 - Alba, Juana Garcia A1 - Jurisch, Nicole A1 - Hagemann, Ulrike A1 - Sachs, Torsten A1 - Sommer, Michael A1 - Augustin, Jürgen T1 - A simple calculation algorithm to separate high-resolution CH4 flux measurements into ebullition- and diffusion-derived components JF - Atmospheric measurement techniques : an interactive open access journal of the European Geosciences Union N2 - Processes driving the production, transformation and transport of methane (CH4 / in wetland ecosystems are highly complex. We present a simple calculation algorithm to separate open-water CH4 fluxes measured with automatic chambers into diffusion-and ebullition-derived components. This helps to reveal underlying dynamics, to identify potential environmental drivers and, thus, to calculate reliable CH4 emission estimates. The flux separation is based on identification of ebullition-related sudden concentration changes during single measurements. Therefore, a variable ebullition filter is applied, using the lower and upper quartile and the interquartile range (IQR). Automation of data processing is achieved by using an established R script, adjusted for the purpose of CH4 flux calculation. The algorithm was validated by performing a laboratory experiment and tested using flux measurement data (July to September 2013) from a former fen grassland site, which converted into a shallow lake as a result of rewetting. Ebullition and diffusion contributed equally (46 and 55 %) to total CH4 emissions, which is comparable to ratios given in the literature. Moreover, the separation algorithm revealed a concealed shift in the diurnal trend of diffusive fluxes throughout the measurement period. The water temperature gradient was identified as one of the major drivers of diffusive CH4 emissions, whereas no significant driver was found in the case of erratic CH4 ebullition events. Y1 - 2017 U6 - https://doi.org/10.5194/amt-10-109-2017 SN - 1867-1381 SN - 1867-8548 VL - 10 IS - 1 SP - 109 EP - 118 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Shainyan, Bagrat A. A1 - Belyakov, Alexander V. A1 - Sigolaev, Yurii F. A1 - Khramov, Alexander N. A1 - Kleinpeter, Erich T1 - Molecular Structure and Conformational Analysis of 1-Phenyl-1-X-1-Silacyclohexanes (X = F, Cl) by Electron Diffraction, Low-Temperature NMR, and Quantum Chemical Calculations JF - The journal of organic chemistry N2 - The molecular structure and conformational preferences of 1-phenyl-1-X-1-silacyclohexanes C5H10Si(Ph,X) (X = F (3), Cl (4)) were studied by gas-phase electron diffraction, low-temperature NMR spectroscopy, and high-level quantum chemical calculations. In the gas phase only three (3) and two (4) stable conformers differing in the axial or equatorial location of the phenyl group and the angle of rotation about the Si-C-ph bond (axi and axo denote the Ph group lying in or out of the X-Si-C-ph plane) contribute to the equilibrium. In 3 the ratio Ph-eq:Ph-axo:Ph-axi is 40(12):55(24):5 and 64:20:16 by experiment and theory, respectively. In 4 the ratio Ph-eq:Ph-axo is 79(15):21(15) and 71:29 by experiment and theory (M06-2X calculations), respectively. The gas-phase electron diffraction parameters are in good agreement with those obtained from theory at the M06-2X/aug-ccPVTZ and MP2/aug-cc-pVTZ levels. Unlike the case for M06-2X, MP2 calculations indicate that 3-Ph-eq conformer lies 0.5 kcal/mol higher than the 3-Ph-axo, conformer. As follows from QTAIM analysis, the phenyl group is more stable when it is located in the axial position but produces destabilization of the silacyclohexane ring: By low temperature NMR spectroscopy the six-membered ring interconversion could be frozen, at 103 K and the present conformational equilibria of 3 and 4 could be determined. The ratio of the conformers is 3-Ph-eq:3-Ph-ax = (75-77):(23-25) and 4-Ph-eq:4-Ph-ax = 82:18. Y1 - 2017 U6 - https://doi.org/10.1021/acs.joc.6b02538 SN - 0022-3263 VL - 82 IS - 1 SP - 461 EP - 470 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Martínez-Garzón, Patricia A1 - Kwiatek, Grzegorz A1 - Bohnhoff, Marco A1 - Dresen, Georg T1 - Volumetric components in the earthquake source related to fluid injection and stress state JF - Geophysical research letters N2 - We investigate source processes of fluid-induced seismicity from The Geysers geothermal reservoir in California to determine their relation with hydraulic operations and improve the corresponding seismic hazard estimates. Analysis of 869 well-constrained full moment tensors (M-w 0.8-3.5) reveals significant non-double-couple components (>25%) for about 65% of the events. Volumetric deformation is governed by cumulative injection rates with larger non-double-couple components observed near the wells and during high injection periods. Source mechanisms are magnitude dependent and vary significantly between faulting regimes. Normal faulting events (M-w<2) reveal substantial volumetric components indicating dilatancy in contrast to strike-slip events that have a dominant double-couple source. Volumetric components indicating closure of cracks in the source region are mostly found for reverse faulting events with M-w>2.5. Our results imply that source processes and magnitudes of fluid-induced seismic events are strongly affected by the hydraulic operations, the reservoir stress state, and the faulting regime. KW - non-double-couple components KW - induced seismicity KW - geothermal KW - stress state KW - tensile opening KW - pore pressure Y1 - 2017 U6 - https://doi.org/10.1002/2016GL071963 SN - 0094-8276 SN - 1944-8007 VL - 44 IS - 2 SP - 800 EP - 809 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Lecourieux, Fatma A1 - Kappel, Christian A1 - Pieri, Philippe A1 - Charon, Justine A1 - Pillet, Jeremy A1 - Hilbert, Ghislaine A1 - Renaud, Christel A1 - Gomes, Eric A1 - Delrot, Serge A1 - Lecourieux, David T1 - Dissecting the Biochemical and Transcriptomic Effects of a Locally Applied Heat Treatment on Developing Cabernet Sauvignon Grape Berries JF - Frontiers in plant science N2 - Reproductive development of grapevine and berry composition are both strongly influenced by temperature. To date, the molecular mechanisms involved in grapevine berries response to high temperatures are poorly understood. Unlike recent data that addressed the effects on berry development of elevated temperatures applied at the whole plant level, the present work particularly focuses on the fruit responses triggered by direct exposure to heat treatment (HT). In the context of climate change, this work focusing on temperature effect at the microclimate level is of particular interest as it can help to better understand the consequences of leaf removal (a common viticultural practice) on berry development. HT (+8 degrees C) was locally applied to clusters from Cabernet Sauvignon fruiting cuttings at three different developmental stages (middle green, veraison and middle ripening). Samples were collected 1, 7, and 14 days after treatment and used for metabolic and transcriptomic analyses. The results showed dramatic and specific biochemical and transcriptomic changes in heat exposed berries, depending on the developmental stage and the stress duration. When applied at the herbaceous stage, HT delayed the onset of veraison. Heating also strongly altered the berry concentration of amino acids and organic acids (e.g., phenylalanine, raminobutyric acid and malate) and decreased the anthocyanin content at maturity. These physiological alterations could be partly explained by the deep remodeling of transcriptome in heated berries. More than 7000 genes were deregulated in at least one of the nine experimental conditions. The most affected processes belong to the categories "stress responses," protein metabolism" and "secondary metabolism," highlighting the intrinsic capacity of grape berries to perceive HT and to build adaptive responses. Additionally, important changes in processes related to "transport," "hormone" and "cell wall" might contribute to the postponing of veraison. Finally, opposite effects depending on heating duration were observed for genes encoding enzymes of the general phenylpropanoid pathway, suggesting that the HI induced decrease in anthocyanin content may result from a combination of transcript abundance and product degradation. KW - grapevine KW - berry development KW - microclimate KW - high temperature KW - microarrays KW - metabolomics/metabolite profiling KW - climate change Y1 - 2017 U6 - https://doi.org/10.3389/fpls.2017.00053 SN - 1664-462X VL - 8 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Hildebrand, Viet A1 - Laschewsky, Andre A1 - Päch, Michael A1 - Müller-Buschbaum, Peter A1 - Papadakis, Christine M. T1 - Effect of the zwitterion structure on the thermo-responsive behaviour of poly(sulfobetaine methacrylates) JF - Polymer Chemistry N2 - A series of new sulfobetaine methacrylates, including nitrogen-containing saturated heterocycles, was synthesised by systematically varying the substituents of the zwitterionic group. Radical polymerisation via the RAFT (reversible addition–fragmentation chain transfer) method in trifluoroethanol proceeded smoothly and was well controlled, yielding polymers with predictable molar masses. Molar mass analysis and control of the end-group fidelity were facilitated by end-group labeling with a fluorescent dye. The polymers showed distinct thermo-responsive behaviour of the UCST (upper critical solution temperature) type in an aqueous solution, which could not be simply correlated to their molecular structure via an incremental analysis of the hydrophilic and hydrophobic elements incorporated within them. Increasing the spacer length separating the ammonium and the sulfonate groups of the zwitterion moiety from three to four carbons increased the phase transition temperatures markedly, whereas increasing the length of the spacer separating the ammonium group and the carboxylate ester group on the backbone from two to three carbons provoked the opposite effect. Moreover, the phase transition temperatures of the analogous polyzwitterions decreased in the order dimethylammonio > morpholinio > piperidinio alkanesulfonates. In addition to the basic effect of the polymers’ precise molecular structure, the concentration and the molar mass dependence of the phase transition temperatures were studied. Furthermore, we investigated the influence of added low molar mass salts on the aqueous-phase behaviour for sodium chloride and sodium bromide as well as sodium and ammonium sulfate. The strong effects evolved in a complex way with the salt concentration. The strength of these effects depended on the nature of the anion added, increasing in the order sulfate < chloride < bromide, thus following the empirical Hofmeister series. In contrast, no significant differences were observed when changing the cation, i.e. when adding sodium or ammonium sulfate. Y1 - 2016 U6 - https://doi.org/10.1039/c6py01220e SN - 1759-9954 SN - 1759-9962 VL - 8 SP - 310 EP - 322 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Hoogenboom, Richard A1 - Schlaad, Helmut T1 - Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides JF - Polymer Chemistry N2 - This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self-assembly, and applications. Y1 - 2016 U6 - https://doi.org/10.1039/c6py01320a SN - 1759-9954 SN - 1759-9962 VL - 8 IS - 1 SP - 24 EP - 40 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Schürmann, Robin Mathis A1 - Bald, Ilko T1 - Real-time monitoring of plasmon induced dissociative electron transfer to the potential DNA radiosensitizer 8-bromoadenine JF - Nanoscale N2 - The excitation of localized surface plasmons in noble metal nanoparticles (NPs) results in different nanoscale effects such as electric field enhancement, the generation of hot electrons and a temperature increase close to the NP surface. These effects are typically exploited in diverse fields such as surface-enhanced Raman scattering (SERS), NP catalysis and photothermal therapy (PTT). Halogenated nucleobases are applied as radiosensitizers in conventional radiation cancer therapy due to their high reactivity towards secondary electrons. Here, we use SERS to study the transformation of 8-bromoadenine ((8Br)A) into adenine on the surface of Au and AgNPs upon irradiation with a low-power continuous wave laser at 532, 633 and 785 nm, respectively. The dissociation of (8Br)A is ascribed to a hot-electron transfer reaction and the underlying kinetics are carefully explored. The reaction proceeds within seconds or even milliseconds. Similar dissociation reactions might also occur with other electrophilic molecules, which must be considered in the interpretation of respective SERS spectra. Furthermore, we suggest that hot-electron transfer induced dissociation of radiosensitizers such as (8Br)A can be applied in the future in PTT to enhance the damage of tumor tissue upon irradiation. Y1 - 2017 U6 - https://doi.org/10.1039/c6nr08695k SN - 2040-3364 SN - 2040-3372 VL - 9 SP - 1951 EP - 1955 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Gerecke, Christian A1 - Edlich, Alexander A1 - Giulbudagian, Michael A1 - Schumacher, Fabian A1 - Zhang, Nan A1 - Said, Andre A1 - Yealland, Guy A1 - Lohan, Silke B. A1 - Neumann, Falko A1 - Meinke, Martina C. A1 - Ma, Nan A1 - Calderon, Marcelo A1 - Hedtrich, Sarah A1 - Schaefer-Korting, Monika A1 - Kleuser, Burkhard T1 - Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes JF - Nanotoxicology N2 - Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers. tNG_dPG_tPG are the combination of dPG with poly(glycidyl methyl ether-co-ethyl glycidyl ether) (p(GME-co-EGE)) and tNG_dPG_pNIPAM the one with poly(N-isopropylacrylamide) (pNIPAM). Both thermoresponsive nanogels are able to incorporate high amounts of dexamethasone and tacrolimus, drugs used in the treatment of severe skin diseases. Cellular uptake, intracellular localization and the toxicological properties of the tNGs were comprehensively characterized in primary normal human keratinocytes (NHK) and in spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (HaCaT). Laser scanning confocal microscopy revealed fluorescently labeled tNGs entered into the cells and localized predominantly within lysosomal compartments. MTT assay, comet assay and carboxy-H2DCFDA assay, demonstrated neither cytotoxic or genotoxic effects, nor any induction of reactive oxygen species of the tNGs in keratinocytes. In addition, both tNGs were devoid of eye irritation potential as shown by bovine corneal opacity and permeability (BCOP) test and red blood cell (RBC) hemolysis assay. Therefore, our study provides evidence that tNGs are locally well tolerated and underlines their potential for cutaneous drug delivery. KW - Drug delivery KW - nanoparticles KW - particle characterization KW - keratinocytes KW - nanotoxicology Y1 - 2017 U6 - https://doi.org/10.1080/17435390.2017.1292371 SN - 1743-5390 SN - 1743-5404 VL - 11 SP - 267 EP - 277 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Lorenz, U. A1 - Saalfrank, Peter T1 - A novel system-bath Hamiltonian for vibration-phonon coupling BT - Formulation, and application to the relaxation of Si-H and Si-D bending modes of H/D:Si(100)-(2 x 1) JF - Chemical physics : a journal devoted to experimental and theoretical research involving problems of both a chemical and physical nature N2 - We present a rigorous method to set up a system-bath Hamiltonian for the coupling of adsorbate vibrations (the system) to surface phonons (the bath). The Hamiltonian is straightforward to derive and exact up to second order in the environment coordinates, thus capable of treating one- and two-phonon contributions to vibration-phonon coupling. The construction of the Hamiltonian uses orthogonal coordinates for system and bath modes, is based on an embedded cluster approach, and generalizes previous Hamiltonians of a similar type, but avoids several (additional) approximations. While the parametrization of the full Hamiltonian is in principle feasible by a first principles quantum mechanical treatment, here we adopt in the spirit of a QM/MM model a combination of density functional theory (“QM”, for the system) and a semiempirical forcefield (“MM”, for the bath). We apply the Hamiltonian to a fully H-covered Si(100)-(2 × 1) surface, using Fermi’s Golden Rule to obtain vibrational relaxation rates of various H–Si bending modes of this system. As in earlier work it is found that the relaxation is dominated by two-phonon contributions because of an energy gap between the Si–H bending modes and the Si phonon bands. We obtain vibrational lifetimes (of the first excited state) on the order of 2 ps at K. The lifetimes depend only little on the type of bending mode (symmetric vs. antisymmetric, parallel vs. perpendicular to the Si2H2 dimers). They decrease by a factor of about two when heating the surface to 300 K. We also study isotope effects by replacing adsorbed H atoms by deuterium, D. The Si–D bending modes are shifted into the Si phonon band of the solid, opening up one-phonon decay channels and reducing the lifetimes to few hundred fs. Y1 - 2016 U6 - https://doi.org/10.1016/j.chemphys.2016.06.004 SN - 0301-0104 SN - 1873-4421 VL - 482 SP - 69 EP - 80 PB - Elsevier Science CY - Amsterdam ER - TY - JOUR A1 - Kehlmaier, Christian A1 - Barlow, Axel A1 - Hastings, Alexander K. A1 - Vamberger, Melita A1 - Paijmans, Johanna L. A. A1 - Steadman, David W. A1 - Albury, Nancy A. A1 - Franz, Richard A1 - Hofreiter, Michael A1 - Fritz, Uwe T1 - Tropical ancient DNA reveals relationships of the extinct bahamian giant tortoise Chelonoidis alburyorum JF - Proceedings of the Royal Society of London : Series B, Biological sciences N2 - Ancient DNA of extinct species from the Pleistocene and Holocene has provided valuable evolutionary insights. However, these are largely restricted to mammals and high latitudes because DNA preservation in warm climates is typically poor. In the tropics and subtropics, non-avian reptiles constitute a significant part of the fauna and little is known about the genetics of the many extinct reptiles from tropical islands. We have reconstructed the near-complete mitochondrial genome of an extinct giant tortoise from the Bahamas (Chelonoidis alburyorum) using an approximately 1000-year-old humerus from a water-filled sinkhole (blue hole) on Great Abaco Island. Phylogenetic and molecular clock analyses place this extinct species as closely related to Galapagos (C. niger complex) and Chaco tortoises (C. chilensis), and provide evidence for repeated overseas dispersal in this tortoise group. The ancestors of extant Chelonoidis species arrived in South America from Africa only after the opening of the Atlantic Ocean and dispersed from there to the Caribbean and the Galapagos Islands. Our results also suggest that the anoxic, thermally buffered environment of blue holes may enhance DNA preservation, and thus are opening a window for better understanding evolution and population history of extinct tropical species, which would likely still exist without human impact. KW - Bahamas KW - biogeography KW - extinction KW - palaeontology KW - phylogeny Y1 - 2017 U6 - https://doi.org/10.1098/rspb.2016.2235 SN - 0962-8452 SN - 1471-2954 VL - 284 PB - The Royal Society CY - London ER - TY - JOUR A1 - Myachykov, Andriy A1 - Chapman, Ashley J. A1 - Fischer, Martin H. T1 - Cross-representational interactions BT - Interface and overlap mechanisms JF - Frontiers in psychology N2 - A crucial question facing cognitive science concerns the nature of conceptual representations as well as the constraints on the interactions between them. One specific question we address in this paper is what makes cross-representational interplay possible? We offer two distinct theoretical scenarios: according to the first scenario, co-activated knowledge representations interact with the help of an interface established between them via congruent activation in a mediating third-party general cognitive mechanism, e.g., attention. According to the second scenario, co-activated knowledge representations interact due to an overlap between their features, for example when they share a magnitude component. First, we make a case for cross representational interplay based on grounded and situated theories of cognition. Second, we discuss interface-based interactions between distinct (i.e., non-overlapping) knowledge representations. Third, we discuss how co-activated representations may share their architecture via partial overlap. Finally, we outline constraints regarding the flexibility of these proposed mechanisms. KW - representation KW - cross-representational interaction KW - simulation KW - embodiment KW - grounded cognition Y1 - 2017 SN - 1664-1078 VL - 7 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Schimka, Selina A1 - Lomadze, Nino A1 - Rabe, Maren A1 - Kopyshev, Alexey A1 - Lehmann, Maren A1 - von Klitzing, Regine A1 - Rumyantsev, Artem M. A1 - Kramarenko, Elena Yu. A1 - Santer, Svetlana T1 - Photosensitive microgels containing azobenzene surfactants of different charges JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - We report on light sensitive microgel particles that can change their volume reversibly in response to illumination with light of different wavelengths. To make the anionic microgels photosensitive we add surfactants with a positively charged polyamine head group and an azobenzene containing tail. Upon illumination, azobenzene undergoes a reversible photo-isomerization reaction from a trans- to a cis-state accompanied by a change in the hydrophobicity of the surfactant. Depending on the isomerization state, the surfactant molecules are either accommodated within the microgel (trans- state) resulting in its shrinkage or desorbed back into water (cis-isomer) letting the microgel swell. We have studied three surfactants differing in the number of amino groups, so that the number of charges of the surfactant head varies between 1 and 3. We have found experimentally and theoretically that the surfactant concentration needed for microgel compaction increases with decreasing number of charges of the head group. Utilization of polyamine azobenzene containing surfactants for the light triggered remote control of the microgel size opens up a possibility for applications of light responsive microgels as drug carriers in biology and medicine. Y1 - 2016 U6 - https://doi.org/10.1039/c6cp04555c SN - 1463-9076 SN - 1463-9084 VL - 19 SP - 108 EP - 117 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - von Klitzing, Regine A1 - Stehl, Dimitrij A1 - Pogrzeba, Tobias A1 - Schomaäcker, Reinhard A1 - Minullina, Renata A1 - Panchal, Abhishek A1 - Konnova, Svetlana A1 - Fakhrullin, Rawil A1 - Koetz, Joachim A1 - Moehwald, Helmuth A1 - Lvov, Yuri T1 - Halloysites Stabilized Emulsions for Hydroformylation of Long Chain Olefins JF - Advanced materials interfaces N2 - Halloysites as tubular alumosilicates are introduced as inexpensive natural nanoparticles to form and stabilize oil-water emulsions. This stabilized emulsion is shown to enable efficient interfacial catalytic reactions. Yield, selectivity, and product separation can be tremendously enhanced, e.g., for the hydroformylation reaction of dodecene to tridecanal. In perspective, this type of formulation may be used for oil spill dispersions. The key elements of the described formulations are clay nanotubes (halloysites) which are highly anisometric, can be filled by helper molecules, and are abundantly available in thousands of tons, making this technology scalable for industrial applications. Y1 - 2016 U6 - https://doi.org/10.1002/admi.201600435 SN - 2196-7350 VL - 4 IS - 1 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Raatz, Michael A1 - Weikl, Thomas R. T1 - Membrane Tubulation by Elongated and Patchy Nanoparticles JF - Advanced materials interfaces N2 - Advances in nanotechnology lead to an increasing interest in how nanoparticles interact with biomembranes. Nanoparticles are wrapped spontaneously by biomembranes if the adhesive interactions between the particles and membranes compensate for the cost of membrane bending. In the last years, the cooperative wrapping of spherical nanoparticles in membrane tubules has been observed in experiments and simulations. For spherical nanoparticles, the stability of the particle-filled membrane tubules strongly depends on the range of the adhesive particle-membrane interactions. In this article, it is shown via modeling and energy minimization that elongated and patchy particles are wrapped cooperatively in membrane tubules that are highly stable for all ranges of the particle-membrane interactions, compared to individual wrapping of the particles. The cooperative wrapping of linear chains of elongated or patchy particles in membrane tubules may thus provide an efficient route to induce membrane tubulation, or to store such particles in membranes. Y1 - 2016 U6 - https://doi.org/10.1002/admi.201600325 SN - 2196-7350 VL - 4 IS - 1 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Sahle, Fitsum Feleke A1 - Gerecke, Christian A1 - Kleuser, Burkhard A1 - Bodmeier, Roland T1 - Formulation and comparative in vitro evaluation of various dexamethasone-loaded pH-sensitive polymeric nanoparticles intended for dermal applications JF - International Journal of Pharmaceutics N2 - pH-sensitive nanoparticles have a great potential for dermal and transfollicular drug delivery. In this study, pH-sensitive, dexamethasone-loaded Eudragit (R) L 100, Eudragit (R) L 100-55, Eudragit (R) S 100, HPMCP-50, HPMCP-55 and cellulose acetate phthalate nanoparticles were prepared by nanoprecipitation and characterized. The pH-dependent swelling, erosion, dissolution and drug release kinetics were investigated in vitro using dynamic light scattering and Franz diffusion cells, respectively. Their toxicity potential was assessed by the ROS and MTT assays. 100-700 nm nanoparticles with high drug loading and entrapment efficiency were obtained. The nanoparticles bear no toxicity potential. Cellulose phthalates nanoparticles were more sensitive to pH than acrylates nanoparticles. They dissolved in 10 mM pH 7.5 buffer and released > 80% of the drug within 7 h. The acrylate nanoparticles dissolved in 40 mM pH 7.5 buffer and released 65-70% of the drug within 7 h. The nanoparticles remained intact in 10 and 40 mM pH 6.0 buffers (HPMCP nanoparticles dissolved in 40 mM pH 6.0 buffer) and released slowly. The nanoparticles properties could be modulated by blending the different polymers. In conclusion, various pH-sensitive nanoparticles that could release differently on the skin surface and dissolve and release in the hair follicles were obtained. KW - Cellulose acetate phthalate KW - Dexamethasone KW - Eudragit (R) KW - HPMCP KW - pH-sensitive nanoparticle KW - Skin nanocarrier Y1 - 2016 U6 - https://doi.org/10.1016/j.ijpharm.2016.11.029 SN - 0378-5173 SN - 1873-3476 VL - 516 IS - 1-2 SP - 21 EP - 31 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Goulet-Hanssens, Alexis A1 - Utecht, Manuel A1 - Mutruc, Dragos A1 - Titov, Evgenii A1 - Schwarz, Jutta A1 - Grubert, Lutz A1 - Bleger, David A1 - Saalfrank, Peter A1 - Hecht, Stefan T1 - Electrocatalytic Z -> E Isomerization of Azobenzenes JF - Journal of the American Chemical Society N2 - A variety of azobenzenes were synthesized to study the behavior of their E and Z isomers upon electrochemical reduction. Our results show that the radical anion of the Z isomer is able to rapidly isomerize to the corresponding E configured counterpart with a dramatically enhanced rate as compared to the neutral species. Due to a subsequent electron transfer from the formed E radical anion to the neutral Z starting material the overall transformation is catalytic in electrons; i.e., a substoichiometric amount of reduced species can isomerize the entire mixture. This pathway greatly increases the efficiency of (photo)switching while also allowing one to reach photostationary state compositions that are not restricted to the spectral separation of the individual azobenzene isomers and their quantum yields. In addition, activating this radical isomerization pathway with photoelectron transfer agents allows us to override the intrinsic properties of an azobenzene species by triggering the reverse isomerization direction (Z -> E) by the same wavelength of light, which normally triggers E -> Z isomerization. The behavior we report appears to be general, implying that the metastable isomer of a photoswitch can be isomerized to the more stable one catalytically upon reduction, permitting the optimization of azobenzene switching in new as well as indirect ways. Y1 - 2017 U6 - https://doi.org/10.1021/jacs.6b10822 SN - 0002-7863 VL - 139 IS - 1 SP - 335 EP - 341 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Safdari, Hadiseh A1 - Cherstvy, Andrey G. A1 - Chechkin, Aleksei V. A1 - Bodrova, Anna A1 - Metzler, Ralf T1 - Aging underdamped scaled Brownian motion BT - Ensemble- and time-averaged particle displacements, nonergodicity, and the failure of the overdamping approximation JF - Physical review : E, Statistical, nonlinear and soft matter physics N2 - We investigate both analytically and by computer simulations the ensemble- and time-averaged, nonergodic, and aging properties of massive particles diffusing in a medium with a time dependent diffusivity. We call this stochastic diffusion process the (aging) underdamped scaled Brownian motion (UDSBM). We demonstrate how the mean squared displacement (MSD) and the time-averaged MSD of UDSBM are affected by the inertial term in the Langevin equation, both at short, intermediate, and even long diffusion times. In particular, we quantify the ballistic regime for the MSD and the time-averaged MSD as well as the spread of individual time-averaged MSD trajectories. One of the main effects we observe is that, both for the MSD and the time-averaged MSD, for superdiffusive UDSBM the ballistic regime is much shorter than for ordinary Brownian motion. In contrast, for subdiffusive UDSBM, the ballistic region extends to much longer diffusion times. Therefore, particular care needs to be taken under what conditions the overdamped limit indeed provides a correct description, even in the long time limit. We also analyze to what extent ergodicity in the Boltzmann-Khinchin sense in this nonstationary system is broken, both for subdiffusive and superdiffusive UDSBM. Finally, the limiting case of ultraslow UDSBM is considered, with a mixed logarithmic and power-law dependence of the ensemble-and time-averaged MSDs of the particles. In the limit of strong aging, remarkably, the ordinary UDSBM and the ultraslow UDSBM behave similarly in the short time ballistic limit. The approaches developed here open ways for considering other stochastic processes under physically important conditions when a finite particle mass and aging in the system cannot be neglected. Y1 - 2017 U6 - https://doi.org/10.1103/PhysRevE.95.012120 SN - 2470-0045 SN - 2470-0053 VL - 95 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Gong, Chen Chris A1 - Klumpp, Stefan T1 - Modeling sRNA-Regulated Plasmid Maintenance JF - PLoS one N2 - We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid. Key to their function is the tight regulation of expression of a protein toxin by an sRNA antitoxin. Here, we focus on the nonlinear nature of the regulatory circuit dynamics of the toxin-antitoxin mechanism. The mechanism relies on a transient increase in protein concentration rather than on the steady state of the genetic circuit. Through a systematic analysis of the parameter dependence of this transient increase, we confirm some known design features of this system and identify new ones: for an efficient toxin-antitoxin mechanism, the synthesis rate of the toxin’s mRNA template should be lower that of the sRNA antitoxin, the mRNA template should be more stable than the sRNA antitoxin, and the mRNA-sRNA complex should be more stable than the sRNA antitoxin. Moreover, a short half-life of the protein toxin is also beneficial to the function of the toxin-antitoxin system. In addition, we study a therapeutic scenario in which a competitor mRNA is introduced to sequester the sRNA antitoxin, causing the toxic protein to be expressed. Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0169703 SN - 1932-6203 VL - 12 PB - PLoS CY - San Fransisco ER - TY - GEN A1 - Kocyan, Alexander A1 - Wiland-Szymanska, Justyna T1 - A new name and a new combination for Friedmannia nom. illeg. (Hypoxidaceae) T2 - Phytotaxa : a rapid international journal for accelerating the publication of botanical taxonomy N2 - Recently, Kocyan & Wiland-Szymańska (2016) have published a thorough research article on one of the outstanding members of the family Hypoxidaceae on the Seychelles, which resulted in the raise of a new genus (Friedmannia Kocyan & Wiland-Szymańska 2016: 60) to accommodate the former Curculigo seychellensis Bojer ex Baker (1877: 368). However, it has turned out that the name Friedmannia Chantanachat & Bold (1962: 45) already exists in literature for a green alga, which renders the new hypoxid genus illegitimate (Melbourne Code; McNeill et al. 2012). Therefore, we assign a new generic epithet to Curculigo seychellensis. Y1 - 2017 U6 - https://doi.org/10.11646/phytotaxa.291.3.10 SN - 1179-3155 SN - 1179-3163 VL - 291 IS - 3 SP - 239 EP - 239 PB - Magnolia Press CY - Auckland ER - TY - JOUR A1 - Behrendt, Felix Nicolas A1 - Schlaad, Helmut T1 - Metathesis polymerization of cystine-based macrocycles JF - Polymer Chemistry N2 - Macrocycles based on L-cystine were synthesized by ring-closing metathesis (RCM) and subsequently polymerized by entropy-driven ring-opening metathesis polymerization (ED-ROMP). Monomer conversion reached similar to 80% in equilibrium and the produced poly (ester-amine-disulfide-alkene)s exhibited apparent molar masses (M-w(app)) of up to 80 kDa and dispersities (D) of similar to 2. The polymers can be further functionalized with acid anhydrides and degraded by reductive cleavage of the main-chain disulfide. Y1 - 2016 U6 - https://doi.org/10.1039/c6py01864e SN - 1759-9954 SN - 1759-9962 VL - 8 IS - 2 SP - 366 EP - 369 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Fatfouta, Ramzi A1 - Schröder-Abe, Michela T1 - I can see clearly now BT - clarity of transgression-related motivations JF - Personality and individual differences : an international journal of research into the structure and development of personality, and the causation of individual differences N2 - Past research has revealed that narcissists lack forgiveness. However, little is known about factors that might either buffer or, more critically, enhance the link between narcissism and lack of forgiveness. To address this gap in the literature, the present studies focused on the moderating role of clarity of transgression-related motivations. In an original and a replication study (Ns = 509 and 532, respectively), participants rated their levels of narcissistic admiration and rivalry and recalled a personal episode in which someone had hurt them. Subsequently, participants reported on their lack of forgiveness toward their transgressor. Response speed to these ratings served as an indirect clarity measure, with faster responses indicating greater clarity. In both studies, narcissistic rivalry (but not admiration) was positively related to lack of forgiveness and this relationship was stronger among individuals who were clear about their transgression-related motivations. Results inform our understanding of socio-emotional factors that contribute to narcissists' lack of forgiveness following interpersonal hurt. KW - Narcissism KW - Forgiveness KW - Interpersonal transgressions KW - Social relationships KW - Indirect measurement Y1 - 2016 U6 - https://doi.org/10.1016/j.paid.2016.10.010 SN - 0191-8869 VL - 105 SP - 280 EP - 286 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Schmidt, Martin A1 - Jochheim, Hubert A1 - Kersebaum, Kurt-Christian A1 - Lischeid, Gunnar A1 - Nendel, Claas T1 - Gradients of microclimate, carbon and nitrogen in transition zones of fragmented landscapes - a review JF - Agricultural and forest meteorology N2 - Fragmentation of landscapes creates a transition zone in between natural habitats or different kinds of land use. In forested and agricultural landscapes with transition zones, microclimate and matter cycling are markedly altered. This probably accelerates and is intensified by global warming. However, there is no consensus on defining transition zones and quantifying relevant variables for microclimate and matter cycling across disciplines. This article is an attempt to a) revise definitions and offer a framework for quantitative ecologists, b) review the literature on microclimate and matter cycling in transition zones and c) summarise this information using meta-analysis to better understand bio-geochemical and bio-geophysical processes and their spatial extent in transition zones. We expect altered conditions in soils of transition zones to be 10-20 m with a maximum of 50 m, and 25-50 m for above-ground space with a maximum of 125 m. KW - Edge effects KW - Ecological boundaries KW - Matter cycling KW - Matter dynamics KW - Framework quantitative ecology KW - Ecotone hierarchy Y1 - 2016 U6 - https://doi.org/10.1016/j.agrformet.2016.10.022 SN - 0168-1923 SN - 1873-2240 VL - 232 SP - 659 EP - 671 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ehlert, Christopher A1 - Klamroth, Tillmann T1 - The quest for best suited references for configuration interaction singles calculations of core excited states JF - Journal of computational chemistry : organic, inorganic, physical, biological N2 - Near edge X-ray absorption fine structure (NEXAFS) simulations based on the conventional configuration interaction singles (CIS) lead to excitation energies, which are systematically blue shifted. Using a (restricted) open shell core hole reference instead of the Hartree Fock (HF) ground state orbitals improves (Decleva et al., Chem. Phys., 1992, 168, 51) excitation energies and the shape of the spectra significantly. In this work, we systematically vary the underlying SCF approaches, that is, based on HF or density functional theory, to identify best suited reference orbitals using a series of small test molecules. We compare the energies of the K edges and NEXAFS spectra to experimental data. The main improvement compared to conventional CIS, that is, using HF ground state orbitals, is due to the electrostatic influence of the core hole. Different SCF approaches, density functionals, or the use of fractional occupations lead only to comparably small changes. Furthermore, to account for bigger systems, we adapt the core-valence separation for our approach. We demonstrate that the good quality of the spectrum is not influenced by this approximation when used together with the non-separated ground state wave function. Simultaneously, the computational demands are reduced remarkably. (C) 2016 Wiley Periodicals, Inc. KW - core excited states KW - configuration interaction KW - near edge X-ray absorption fine structure Y1 - 2016 U6 - https://doi.org/10.1002/jcc.24531 SN - 0192-8651 SN - 1096-987X VL - 38 SP - 116 EP - 126 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Lippold, Holger A1 - Eidner, Sascha A1 - Kumke, Michael Uwe A1 - Lippmann-Pipke, Johanna T1 - Dynamics of metal-humate complexation equilibria as revealed by isotope exchange studies - a matter of concentration and time JF - Geochimica et cosmochimica acta : journal of the Geochemical Society and the Meteoritical Society N2 - Complexation with dissolved humic matter can be crucial in controlling the mobility of toxic or radioactive contaminant metals. For speciation and transport modelling, a dynamic equilibrium process is commonly assumed, where association and dissociation run permanently. This is, however, questionable in view of reported observations of a growing resistance to dissociation over time. In this study, the isotope exchange principle was employed to gain direct insight into the dynamics of the complexation equilibrium, including kinetic inertisation phenomena. Terbium(III), an analogue of trivalent actinides, was used as a representative of higher-valent metals. Isotherms of binding to (flocculated) humic acid, determined by means of Tb-160 as a radiotracer, were found to be identical regardless of whether the radioisotope was introduced together with the bulk of stable Tb-159 or subsequently after pre-equilibration for up to 3 months. Consequently, there is a permanent exchange of free and humic-bound Tb since all available binding sites are occupied in the plateau region of the isotherm. The existence of a dynamic equilibrium was thus evidenced. There was no indication of an inertisation under these experimental conditions. If the small amount of Tb-160 was introduced prior to saturation with Tb-159, the expected partial desorption of Tb-160 occurred at much lower rates than observed for the equilibration process in the reverse procedure. In addition, the rates decreased with time of pre-equilibration. Inertisation phenomena are thus confined to the stronger sites of humic molecules (occupied at low metal concentrations). Analysing the time-dependent course of isotope exchange according to first-order kinetics indicated that up to 3 years are needed to attain equilibrium. Since, however, metal-humic interaction remains reversible, exchange of metals between humic carriers and mineral surfaces cannot be neglected on the long time scale to be considered in predictive transport models. KW - Humic substances KW - Metal complexation KW - Kinetics KW - Reversibility KW - Isotope exchange KW - Dynamic equilibrium Y1 - 2016 U6 - https://doi.org/10.1016/j.gca.2016.10.019 SN - 0016-7037 SN - 1872-9533 VL - 197 SP - 62 EP - 70 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Knapmeyer-Endrun, Brigitte A1 - Krüger, Frank A1 - Geissler, Wolfram H. T1 - Upper mantle structure across the Trans-European Suture Zone imaged by S-receiver functions JF - Earth & planetary science letters N2 - We present a high-resolution study of the upper mantle structure of Central Europe, including the western part of the East European Platform, based on S-receiver functions of 345 stations. A distinct contrast is found between Phanerozoic Europe and the East European Craton across the Trans-European Suture Zone. To the west, a pronounced velocity reduction with depth interpreted as lithosphere-asthenosphere boundary (LAB) is found at an average depth of 90 km. Beneath the craton, no strong and continuous LAB conversion is observed. Instead we find a distinct velocity reduction within the lithosphere, at 80-120 km depth. This mid-lithospheric discontinuity (MLD) is attributed to a compositional boundary between depleted and more fertile lithosphere created by late Proterozoic metasomatism. A potential LAB phase beneath the craton is very weak and varies in depth between 180 and 250 km, consistent with a reduced velocity contrast between the lower lithosphere and the asthenosphere. Within the Trans-European Suture Zone, lithospheric structure is characterized by strong heterogeneity. A dipping or step-wise increase to LAB depth of 150 km is imaged from Phanerozoic Europe to 20-22 degrees E, whereas no direct connection to the cratonic LAB or MLD to the east is apparent. At larger depths, a positive conversion associated with the lower boundary of the asthenosphere is imaged at 210-250 km depth beneath Phanerozoic Europe, continuing down to 300 km depth beneath the craton. Conversions from both 410 km and 660 km discontinuities are found at their nominal depth beneath Phanerozoic Europe, and the discontinuity at 410 km depth can also be traced into the craton. A potential negative conversion on top of the 410 km discontinuity found in migrated images is analyzed by modeling and attributed to interference with other converted phases. KW - lithosphere-asthenosphere boundary KW - mid-lithospheric discontinuity KW - Lehmann discontinuity KW - S-receiver functions KW - Trans-European Suture Zone KW - East European Craton Y1 - 2016 U6 - https://doi.org/10.1016/j.epsl.2016.11.011 SN - 0012-821X SN - 1385-013X VL - 458 SP - 429 EP - 441 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Sippel, Judith A1 - Meessen, Christian A1 - Cacace, Mauro A1 - Mechie, James A1 - Fishwick, Stewart A1 - Heine, Christian A1 - Scheck-Wenderoth, Magdalena A1 - Strecker, Manfred T1 - The Kenya rift revisited BT - insights into lithospheric strength through data-driven 3-D gravity and thermal modelling JF - Solid earth N2 - We present three-dimensional (3-D) models that describe the present-day thermal and rheological state of the lithosphere of the greater Kenya rift region aiming at a better understanding of the rift evolution, with a particular focus on plume-lithosphere interactions. The key methodology applied is the 3-D integration of diverse geological and geophysical observations using gravity modelling. Accordingly, the resulting lithospheric-scale 3-D density model is consistent with (i) reviewed descriptions of lithological variations in the sedimentary and volcanic cover, (ii) known trends in crust and mantle seismic velocities as revealed by seismic and seismological data and (iii) the observed gravity field. This data-based model is the first to image a 3-D density configuration of the crystalline crust for the entire region of Kenya and northern Tanzania. An upper and a basal crustal layer are differentiated, each composed of several domains of different average densities. We interpret these domains to trace back to the Precambrian terrane amalgamation associated with the East African Orogeny and to magmatic processes during Mesozoic and Cenozoic rifting phases. In combination with seismic velocities, the densities of these crustal domains indicate compositional differences. The derived lithological trends have been used to parameterise steady-state thermal and rheological models. These models indicate that crustal and mantle temperatures decrease from the Kenya rift in the west to eastern Kenya, while the integrated strength of the lithosphere increases. Thereby, the detailed strength configuration appears strongly controlled by the complex inherited crustal structure, which may have been decisive for the onset, localisation and propagation of rifting. Y1 - 2017 U6 - https://doi.org/10.5194/se-8-45-2017 SN - 1869-9510 SN - 1869-9529 VL - 8 SP - 45 EP - 81 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Mohr, Christian Heinrich A1 - Manga, Michael A1 - Wang, Chi-Yuen A1 - Korup, Oliver T1 - Regional changes in streamflow after a megathrust earthquake JF - Earth & planetary science letters N2 - Moderate to large earthquakes can increase the amount of water feeding stream flows, mobilizing excess water from deep groundwater, shallow groundwater, or the vadose zone. Here we examine the regional pattern of streamflow response to the Maule M8.8 earthquake across Chile's diverse topographic and hydro-climatic gradients. We combine streamflow analyses with groundwater flow modeling and a random forest classifier, and find that, after the earthquake, at least 85 streams had a change in flow. Discharge mostly increased () shortly after the earthquake, liberating an excess water volume of >1.1 km3, which is the largest ever reported following an earthquake. Several catchments had increased discharge of >50 mm, locally exceeding seasonal streamflow discharge under undisturbed conditions. Our modeling results favor enhanced vertical permeability induced by dynamic strain as the most probable process explaining the observed changes at the regional scale. Supporting this interpretation, our random forest classification identifies peak ground velocity and elevation extremes as most important for predicting streamflow response. Given the mean recurrence interval of ∼25 yr for >M8.0 earthquakes along the Peru–Chile Trench, our observations highlight the role of earthquakes in the regional water cycle, especially in arid environments. KW - Maule earthquake KW - streamflow response KW - permeability KW - groundwater flow modeling KW - earthquake hydrology Y1 - 2016 U6 - https://doi.org/10.1016/j.epsl.2016.11.013 SN - 0012-821X SN - 1385-013X VL - 458 SP - 418 EP - 428 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Tian, Fang A1 - Cao, Xianyong A1 - Dallmeyer, Anne A1 - Zhao, Yan A1 - Ni, Jian A1 - Herzschuh, Ulrike T1 - Pollen-climate relationships in time (9 ka, 6 ka, 0 ka) and space (upland vs. lowland) in eastern continental Asia JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - Temporal and spatial stability of the vegetation climate relationship is a basic ecological assumption for pollen-based quantitative inferences of past climate change and for predicting future vegetation. We explore this assumption for the Holocene in eastern continental Asia (China, Mongolia). Boosted regression trees (BRT) between fossil pollen taxa percentages (Abies, Artemisia, Betula, Chenopodiaceae, Cyperaceae, Ephedra, Picea, Pinus, Poaceae and Quercus) and climate model outputs of mean annual precipitation (P-ann) and mean temperature of the warmest month (Mt(wa)) for 9 and 6 ka (ka = thousand years before present) were set up and results compared to those obtained from relating modern pollen to modern climate. Overall, our results reveal only slight temporal differences in the pollen climate relationships. Our analyses suggest that the importance of P-ann compared with Mt(wa) for taxa distribution is higher today than it was at 6 ka and 9 ka. In particular, the relevance of P-ann for Picea and Pinus increases and has become the main determinant. This change in the climate tree pollen relationship parallels a widespread tree pollen decrease in north-central China and the eastern Tibetan Plateau. We assume that this is at least partly related to vegetation climate disequilibrium originating from human impact. Increased atmospheric CO2 concentration may have permitted the expansion of moisture-loving herb taxa (Cyperaceae and Poaceae) during the late Holocene into arid/semi-arid areas. We furthermore find that the pollen climate relationship between north-central China and the eastern Tibetan Plateau is generally similar, but that regional differences are larger than temporal differences. In summary, vegetation climate relationships in China are generally stable in space and time, and pollen-based climate reconstructions can be applied to the Holocene. Regional differences imply the calibration-set should be restricted spatially. KW - Boosted regression trees KW - China KW - Holocene KW - Niche stability KW - Pollen-climate relationship KW - Uniformitarianism Y1 - 2016 U6 - https://doi.org/10.1016/j.quascirev.2016.11.027 SN - 0277-3791 VL - 156 SP - 1 EP - 11 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Simons, Nadja K. A1 - Lewinsohn, Thomas A1 - Bluethgen, Nico A1 - Buscot, Francois A1 - Boch, Steffen A1 - Daniel, Rolf A1 - Gossner, Martin M. A1 - Jung, Kirsten A1 - Kaiser, Kristin A1 - Müller, Jörg A1 - Prati, Daniel A1 - Renner, Swen C. A1 - Socher, Stephanie A. A1 - Sonnemann, Ilja A1 - Weiner, Christiane N. A1 - Werner, Michael A1 - Wubet, Tesfaye A1 - Wurst, Susanne A1 - Weisser, Wolfgang W. T1 - Contrasting effects of grassland management modes on species-abundance distributions of multiple groups JF - Agriculture, ecosystems & environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere N2 - Intensive land use is a major cause of biodiversity loss, but most studies comparing the response of multiple taxa rely on simple diversity measures while analyses of other community attributes are only recently gaining attention. Species-abundance distributions (SADs) are a community attribute that can be used to study changes in the overall abundance structure of species groups, and whether these changes are driven by abundant or rare species. We evaluated the effect of grassland management intensity for three land-use modes (fertilization, mowing, grazing) and their combination on species richness and SADs for three belowground (arbuscular mycorrhizal fungi, prokaryotes and insect larvae) and seven aboveground groups (vascular plants, bryophytes and lichens; arthropod herbivores; arthropod pollinators; bats and birds). Three descriptors of SADs were evaluated: general shape (abundance decay rate), proportion of rare species (rarity) and proportional abundance of the commonest species (dominance). Across groups, taxonomic richness was largely unaffected by land-use intensity and only decreased with increasing mowing intensity. Of the three SAD descriptors, abundance decay rate became steeper with increasing combined land-use intensity across groups. This reflected a decrease in rarity among plants, herbivores and vertebrates. Effects of fertilization on the three descriptors were similar to the combined land-use intensity effects. Mowing intensity only affected the SAD descriptors of insect larvae and vertebrates, while grazing intensity produced a range of effects on different descriptors in distinct groups. Overall, belowground groups had more even abundance distribtitions than aboveground groups. Strong differences among aboveground groups and between above- and belowground groups indicate that no single taxonomic group can serve as an indicator for effects in other groups. In the past, the use of SADs has been hampered by concerns over theoretical models underlying specific forms of SADs. Our study shows that SAD descriptors that are not connected to a particular model are suitable to assess the effect of land use on community structure. KW - Biodiversity KW - Cutting frequency KW - Management intensity KW - Rank-abundance KW - Species loss KW - Rarity Y1 - 2017 U6 - https://doi.org/10.1016/j.agee.2016.12.022 SN - 0167-8809 SN - 1873-2305 VL - 237 SP - 143 EP - 153 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Campforts, Benjamin A1 - Schwanghart, Wolfgang A1 - Govers, Gerard T1 - Accurate simulation of transient landscape evolution by eliminating numerical diffusion BT - the TTLEM 1.0 model JF - Earth surface dynamics N2 - Landscape evolution models (LEMs) allow the study of earth surface responses to changing climatic and tectonic forcings. While much effort has been devoted to the development of LEMs that simulate a wide range of processes, the numerical accuracy of these models has received less attention. Most LEMs use first-order accurate numerical methods that suffer from substantial numerical diffusion. Numerical diffusion particularly affects the solution of the advection equation and thus the simulation of retreating landforms such as cliffs and river knickpoints. This has potential consequences for the integrated response of the simulated landscape. Here we test a higher-order flux-limiting finite volume method that is total variation diminishing (TVD-FVM) to solve the partial differential equations of river incision and tectonic displacement. We show that using the TVD-FVM to simulate river incision significantly influences the evolution of simulated landscapes and the spatial and temporal variability of catchment-wide erosion rates. Furthermore, a two-dimensional TVD-FVM accurately simulates the evolution of landscapes affected by lateral tectonic displacement, a process whose simulation was hitherto largely limited to LEMs with flexible spatial discretization. We implement the scheme in TTLEM (TopoToolbox Landscape Evolution Model), a spatially explicit, raster-based LEM for the study of fluvially eroding landscapes in TopoToolbox 2. Y1 - 2017 U6 - https://doi.org/10.5194/esurf-5-47-2017 SN - 2196-6311 SN - 2196-632X VL - 5 IS - 1 SP - 47 EP - 66 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Couto, Rafael C. A1 - Cruz, Vinicius V. A1 - Ertan, Emelie A1 - Eckert, Sebastian A1 - Fondell, Mattis A1 - Dantz, Marcus A1 - Kennedy, Brian A1 - Schmitt, Thorsten A1 - Pietzsch, Annette A1 - Guimaraes, Freddy F. A1 - Agren, Hans A1 - Odelius, Michael A1 - Kimberg, Victor A1 - Föhlisch, Alexander T1 - Selective gating to vibrational modes through resonant X-ray scattering JF - Nature Communications N2 - The dynamics of fragmentation and vibration of molecular systems with a large number of coupled degrees of freedom are key aspects for understanding chemical reactivity and properties. Here we present a resonant inelastic X-ray scattering (RIXS) study to show how it is possible to break down such a complex multidimensional problem into elementary components. Local multimode nuclear wave packets created by X-ray excitation to different core-excited potential energy surfaces (PESs) will act as spatial gates to selectively probe the particular ground-state vibrational modes and, hence, the PES along these modes. We demonstrate this principle by combining ultra-high resolution RIXS measurements for gas-phase water with state-of-the-art simulations. Y1 - 2017 U6 - https://doi.org/10.1038/ncomms14165 SN - 2041-1723 VL - 8 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Hahn, Marc Benjamin A1 - Meyer, Susann A1 - Schröter, Maria-Astrid A1 - Seitz, Harald A1 - Kunte, Hans-Jörg A1 - Solomun, Tihomir A1 - Sturm, Heinz T1 - Direct electron irradiation of DNA in a fully aqueous environment BT - Damage determination in combination with Monte Carlo simulations JF - Physical chemistry, chemical physics : PCCP ; a journal of European chemical societies N2 - We report on a study in which plasmid DNA in water was irradiated with 30 keV electrons generated by a scanning electron microscope and passed through a 100 nm thick Si3N4 membrane. The corresponding Monte Carlo simulations suggest that the kinetic energy spectrum of the electrons throughout the water is dominated by low energy electrons (<100 eV). The DNA radiation damage, single-strand breaks (SSBs) and double-strand breaks (DSBs), was determined by gel electrophoresis. The median lethal dose of D-1/2 = 1.7 +/- 0.3 Gy was found to be much smaller as compared to partially or fully hydrated DNA irradiated under vacuum conditions. The ratio of the DSBs to SSBs was found to be 1 : 12 as compared to 1 : 88 found for hydrated DNA. Our method enables quantitative measurements of radiation damage to biomolecules (DNA, proteins) in solutions under varying conditions (pH, salinity, co-solutes) for an electron energy range which is difficult to probe by standard methods. Y1 - 2016 U6 - https://doi.org/10.1039/c6cp07707b SN - 1463-9076 SN - 1463-9084 VL - 19 IS - 3 SP - 1798 EP - 1805 PB - RSC Publ. CY - Cambridge ER - TY - JOUR A1 - Strunk, Astrid A1 - Knudsen, Mads Faurschou A1 - Egholm, David L. A1 - Jansen, John D. A1 - Levy, Laura B. A1 - Jacobsen, Bo H. A1 - Larsen, Nicolaj K. T1 - One million years of glaciation and denudation history in west Greenland JF - Nature Communications N2 - The influence of major Quaternary climatic changes on growth and decay of the Greenland Ice Sheet, and associated erosional impact on the landscapes, is virtually unknown beyond the last deglaciation. Here we quantify exposure and denudation histories in west Greenland by applying a novel Markov-Chain Monte Carlo modelling approach to all available paired cosmogenic Be-10-Al-26 bedrock data from Greenland. We find that long-term denudation rates in west Greenland range from >50 m Myr(-1) in low-lying areas to similar to 2 m Myr(-1) at high elevations, hereby quantifying systematic variations in denudation rate among different glacial landforms caused by variations in ice thickness across the landscape. We furthermore show that the present day ice-free areas only were ice covered ca. 45% of the past 1 million years, and even less at high-elevation sites, implying that the Greenland Ice Sheet for much of the time was of similar size or even smaller than today. Y1 - 2017 U6 - https://doi.org/10.1038/ncomms14199 SN - 2041-1723 VL - 8 PB - Nature Publishing Group UK CY - London ER - TY - JOUR A1 - Lütkecosmann, Steffi A1 - Warsinke, Axel A1 - Tschöpe, Winfried A1 - Eichler, Rüdiger A1 - Hanack, Katja T1 - A novel monoclonal antibody suitable for the detection of leukotriene B4 JF - Biochemical and biophysical research communications N2 - Leukotriene B4 as an inflammatory mediator is an important biomarker for different respiratory diseases like asthma, chronic obstructive pulmonary disease or cystic lung fibrosis. Therefore the detection of LTB4 is helpful in the diagnosis of these pulmonary diseases. However, until now its determination in exhaled breath condensates suffers from problems of accuracy. Reasons for that could be improper sample collection and preparation methods of condensates and the lack of consistently assay specificity and reproducibility of the used immunoassay detection system. In this study we describe the development and the characterization of a specific monoclonal antibody (S27BC6) against LTB4, its use as molecular recognition element for the development of an enzyme-linked immunoassay to detect LTB4 and discuss possible future diagnostic applications. KW - Leukotriene B4 KW - Monoclonal antibody KW - Immunosensor KW - Chronic obstructive pulmonary disease (COPD) KW - Hapten Y1 - 2017 U6 - https://doi.org/10.1016/j.bbrc.2016.11.157 SN - 0006-291X SN - 1090-2104 VL - 482 IS - 4 SP - 1054 EP - 1059 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Radbruch, Moritz A1 - Pischon, Hannah A1 - Ostrowski, Anja A1 - Volz, Pierre A1 - Brodwolf, Robert A1 - Neumann, Falko A1 - Unbehauen, Michael A1 - Kleuser, Burkhard A1 - Haag, Rainer A1 - Ma, Nan A1 - Alexiev, Ulrike A1 - Mundhenk, Lars A1 - Gruber, Achim D. T1 - Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin JF - Nanoscale Research Letters N2 - Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters, e. g., to facilitate topical therapy in skin diseases. Atopic dermatitis is among the most common inflammatory skin disorders with complex barrier alterations which may affect the efficacy of topical treatment. Here, we tested the penetration behavior and identified target structures of unloaded CMS after topical administration in healthy mice and in mice with oxazolone-induced atopic dermatitis. We further examined whole body distribution and possible systemic side effects after simulating high dosage dermal penetration by subcutaneous injection. Following topical administration, CMS accumulated in the stratum corneum without penetration into deeper viable epidermal layers. The same was observed in atopic dermatitis mice, indicating that barrier alterations in atopic dermatitis had no influence on the penetration of CMS. Following subcutaneous injection, CMS were deposited in the regional lymph nodes as well as in liver, spleen, lung, and kidney. However, in vitro toxicity tests, clinical data, and morphometry-assisted histopathological analyses yielded no evidence of any toxic or otherwise adverse local or systemic effects of CMS, nor did they affect the severity or course of atopic dermatitis. Taken together, CMS accumulate in the stratum corneum in both healthy and inflammatory skin and appear to be highly biocompatible in the mouse even under conditions of atopic dermatitis and thus could potentially serve to create a depot for anti-inflammatory drugs in the skin. KW - CMS KW - Skin KW - Topical treatment KW - Dermal delivery KW - Atopic dermatitis KW - Oxazolone KW - Fluorescence lifetime imaging microscopy KW - Nanomaterials KW - Multi-domain nanoparticles KW - Penetration enhancement Y1 - 2017 U6 - https://doi.org/10.1186/s11671-017-1835-0 SN - 1556-276X VL - 12 IS - 64 PB - Springer CY - New York ER - TY - JOUR A1 - Martins, Renata F. A1 - Fickel, Jörns A1 - Minh Le, A1 - Thanh Van Nguyen, A1 - Nguyen, Ha M. A1 - Timmins, Robert A1 - Gan, Han Ming A1 - Rovie-Ryan, Jeffrine J. A1 - Lenz, Dorina A1 - Förster, Daniel W. A1 - Wilting, Andreas T1 - Phylogeography of red muntjacs reveals three distinct mitochondrial lineages JF - BMC evolutionary biology N2 - Background: The members of the genus Muntiacus are of particular interest to evolutionary biologists due to their extreme chromosomal rearrangements and the ongoing discussions about the number of living species. Red muntjacs have the largest distribution of all muntjacs and were formerly considered as one species. Karyotype differences led to the provisional split between the Southern Red Muntjac (Muntiacus muntjak) and the Northern Red Muntjac (M. vaginalis), but uncertainties remain as, so far, no phylogenetic study has been conducted. Here, we analysed whole mitochondrial genomes of 59 archival and 16 contemporaneous samples to resolve uncertainties about their taxonomy and used red muntjacs as model for understanding the evolutionary history of other species in Southeast Asia. Results: We found three distinct matrilineal groups of red muntjacs: Sri Lankan red muntjacs (including the Western Ghats) diverged first from other muntjacs about 1.5 Mya; later northern red muntjacs (including North India and Indochina) and southern red muntjacs (Sundaland) split around 1.12 Mya. The diversification of red muntjacs into these three main lineages was likely promoted by two Pleistocene barriers: one through the Indian subcontinent and one separating the Indochinese and Sundaic red muntjacs. Interestingly, we found a high level of gene flow within the populations of northern and southern red muntjacs, indicating gene flow between populations in Indochina and dispersal of red muntjacs over the exposed Sunda Shelf during the Last Glacial Maximum. Conclusions: Our results provide new insights into the evolution of species in South and Southeast Asia as we found clear genetic differentiation in a widespread and generalist species, corresponding to two known biogeographical barriers: The Isthmus of Kra and the central Indian dry zone. In addition, our molecular data support either the delineation of three monotypic species or three subspecies, but more importantly these data highlight the conservation importance of the Sri Lankan/South Indian red muntjac. KW - Phylogeography KW - Archival DNA KW - Muntjac KW - Southeast Asia KW - Species complex Y1 - 2017 U6 - https://doi.org/10.1186/s12862-017-0888-0 SN - 1471-2148 VL - 17 IS - 34 PB - BioMed Central CY - London ER - TY - JOUR A1 - Mardoukhi, Ahmad A1 - Mardoukhi, Yousof A1 - Hokka, Mikko A1 - Kuokkala, Veli-Tapani T1 - Effects of strain rate and surface cracks on the mechanical behaviour of Balmoral Red granite JF - Philosophical Transactions of the Royal Society of London, Series A : Mathematical, Physical and Engineering Sciences N2 - This work presents a systematic study on the effects of strain rate and surface cracks on the mechanical properties and behaviour of Balmoral Red granite. The tensile behaviour of the rock was studied at low and high strain rates using Brazilian disc samples. Heat shocks were used to produce samples with different amounts of surface cracks. The surface crack patterns were analysed using optical microscopy, and the complexity of the patterns was quantified by calculating the fractal dimensions of the patterns. The strength of the rock clearly drops as a function of increasing fractal dimensions in the studied strain rate range. However, the dynamic strength of the rock drops significantly faster than the quasi-static strength, and, because of this, also the strain rate sensitivity of the rock decreases with increasing fractal dimensions. This can be explained by the fracture behaviour and fragmentation during the dynamic loading, which is more strongly affected by the heat shock than the fragmentation at low strain rates. KW - split Hopkinson pressure bar KW - rock KW - granite KW - dynamic loading KW - fractal dimension KW - surface cracks Y1 - 2017 U6 - https://doi.org/10.1098/rsta.2016.0179 SN - 1364-503X SN - 1471-2962 VL - 375 IS - 2085 PB - Royal Society CY - London ER - TY - JOUR A1 - Melnick, Daniel A1 - Moreno, Marcos A1 - Quinteros, Javier A1 - Carlos Baez, Juan A1 - Deng, Zhiguo A1 - Li, Shaoyang A1 - Oncken, Onno T1 - The super-interseismic phase of the megathrust earthquake cycle in Chile JF - Geophysical research letters N2 - Along a subduction zone, great megathrust earthquakes recur either after long seismic gaps lasting several decades to centuries or over much shorter periods lasting hours to a few years when cascading successions of earthquakes rupture nearby segments of the fault. We analyze a decade of continuous Global Positioning System observations along the South American continent to estimate changes in deformation rates between the 2010 Maule (M8.8) and 2015 Illapel (M8.3) Chilean earthquakes. We find that surface velocities increased after the 2010 earthquake, in response to continental-scale viscoelastic mantle relaxation and to regional-scale increased degree of interplate locking. We propose that increased locking occurs transiently during a super-interseismic phase in segments adjacent to a megathrust rupture, responding to bending of both plates caused by coseismic slip and subsequent afterslip. Enhanced strain rates during a super-interseismic phase may therefore bring a megathrust segment closer to failure and possibly triggered the 2015 event. KW - megathrust KW - earthquake KW - cycle KW - Chile Y1 - 2017 U6 - https://doi.org/10.1002/2016GL071845 SN - 0094-8276 SN - 1944-8007 VL - 44 IS - 2 SP - 784 EP - 791 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Goychuk, Igor T1 - Quantum ergodicity breaking in semi-classical electron transfer dynamics JF - Physical chemistry, chemical physics : a journal of European Chemical Societies N2 - Can the statistical properties of single-electron transfer events be correctly predicted within a common equilibrium ensemble description? This fundamental in nanoworld question of ergodic behavior is scrutinized within a very basic semi-classical curve-crossing problem. It is shown that in the limit of non-adiabatic electron transfer (weak tunneling) well-described by the Marcus-Levich-Dogonadze (MLD) rate the answer is yes. However, in the limit of the so-called solvent-controlled adiabatic electron transfer, a profound breaking of ergodicity occurs. Namely, a common description based on the ensemble reduced density matrix with an initial equilibrium distribution of the reaction coordinate is not able to reproduce the statistics of single-trajectory events in this seemingly classical regime. For sufficiently large activation barriers, the ensemble survival probability in a state remains nearly exponential with the inverse rate given by the sum of the adiabatic curve crossing (Kramers) time and the inverse MLD rate. In contrast, near to the adiabatic regime, the single-electron survival probability is clearly non-exponential, even though it possesses an exponential tail which agrees well with the ensemble description. Initially, it is well described by a Mittag-Leffler distribution with a fractional rate. Paradoxically, the mean transfer time in this classical on the ensemble level regime is well described by the inverse of the nonadiabatic quantum tunneling rate on a single particle level. An analytical theory is developed which perfectly agrees with stochastic simulations and explains our findings. Y1 - 2016 U6 - https://doi.org/10.1039/c6cp07206b SN - 1463-9076 SN - 1463-9084 VL - 19 SP - 3056 EP - 3066 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Cotronei, Mariantonia A1 - Di Salvo, Rosa A1 - Holschneider, Matthias A1 - Puccio, Luigia T1 - Interpolation in reproducing kernel Hilbert spaces based on random subdivision schemes JF - Journal of computational and applied mathematics N2 - In this paper we present a Bayesian framework for interpolating data in a reproducing kernel Hilbert space associated with a random subdivision scheme, where not only approximations of the values of a function at some missing points can be obtained, but also uncertainty estimates for such predicted values. This random scheme generalizes the usual subdivision by taking into account, at each level, some uncertainty given in terms of suitably scaled noise sequences of i.i.d. Gaussian random variables with zero mean and given variance, and generating, in the limit, a Gaussian process whose correlation structure is characterized and used for computing realizations of the conditional posterior distribution. The hierarchical nature of the procedure may be exploited to reduce the computational cost compared to standard techniques in the case where many prediction points need to be considered. KW - Subdivision schemes KW - Interpolation KW - Simulation of Gaussian processes KW - Bayesian inversion Y1 - 2016 U6 - https://doi.org/10.1016/j.cam.2016.08.002 SN - 0377-0427 SN - 1879-1778 VL - 311 SP - 342 EP - 353 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Michalik-Onichimowska, Aleksandra A1 - Beitz, Toralf A1 - Panne, Ulrich A1 - Löhmannsröben, Hans-Gerd A1 - Riedel, Jens T1 - Microsecond mid-infrared laser pulses for atmospheric pressure laser ablation/ionization of liquid samples JF - Sensors and actuators : B, Chemical N2 - In many laser based ionization techniques with a subsequent drift time separation, the laser pulse generating the ions is considered as the start time to. Therefore, an accurate temporal definition of this event is crucial for the resolution of the experiments. In this contribution, the laser induced plume dynamics of liquids evaporating into atmospheric pressure are visualized for two distinctively different laser pulse widths, Delta t = 6 nanoseconds and Delta tau = 280 microseconds. For ns-pulses the expansion of the generated vapour against atmospheric pressure is found to lead to turbulences inside the gas phase. This results in spatial and temporal broadening of the nascent clouds. A more equilibrated expansion, without artificial smearing of the temporal resolution can, in contrast, be observed to follow mu s-pulse excitation. This leads to the counterintuitive finding that longer laser pulses results in an increased temporal vapour formation definition. To examine if this fume expansion also eventually results in a better definition of ion formation, the nascent vapour plumes were expanded into a linear drift tube ion mobility spectrometer (IMS). This time resolved detection of ion formation corroborates the temporal broadening caused by collisional impeding of the supersonic expansion at atmospheric pressure and the overall better defined ion formation by evaporation with long laser pulses. A direct comparison of the observed results strongly suggests the coexistence of two individual ion formation mechanisms that can be specifically addressed by the use of appropriate laser sources. KW - Laser ablation KW - Ion mobility spectrometry KW - Pulse duration KW - Plume KW - Ionization Y1 - 2016 U6 - https://doi.org/10.1016/j.snb.2016.06.155 SN - 0925-4005 VL - 238 SP - 298 EP - 305 PB - Elsevier CY - Lausanne ER - TY - JOUR A1 - Felgentreff, Tim A1 - Perscheid, Michael A1 - Hirschfeld, Robert T1 - Implementing record and refinement for debugging timing-dependent communication JF - Science of computer programming N2 - Distributed applications are hard to debug because timing-dependent network communication is a source of non-deterministic behavior. Current approaches to debug non deterministic failures include post-mortem debugging as well as record and replay. However, the first impairs system performance to gather data, whereas the latter requires developers to understand the timing-dependent communication at a lower level of abstraction than they develop at. Furthermore, both approaches require intrusive core library modifications to gather data from live systems. In this paper, we present the Peek-At-Talk debugger for investigating non-deterministic failures with low overhead in a systematic, top-down method, with a particular focus on tool-building issues in the following areas: First, we show how our debugging framework Path Tools guides developers from failures to their root causes and gathers run-time data with low overhead. Second, we present Peek-At-Talk, an extension to our Path Tools framework to record non-deterministic communication and refine behavioral data that connects source code with network events. Finally, we scope changes to the core library to record network communication without impacting other network applications. KW - Distributed debugging KW - Record and replay KW - Dynamic analysis KW - Record and refinement Y1 - 2016 U6 - https://doi.org/10.1016/j.scico.2015.11.006 SN - 0167-6423 SN - 1872-7964 VL - 134 SP - 4 EP - 18 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Nelson, Daniel B. A1 - Knohl, Alexander A1 - Sachse, Dirk A1 - Schefulss, Enno A1 - Kahmen, Ansgar T1 - Sources and abundances of leaf waxes in aerosols in central Europe JF - Geochimica et cosmochimica acta : journal of the Geochemical Society and the Meteoritical Society N2 - Atmospheric transport is an understudied mechanism for leaf wax hydrogen isotope applications that contributes to mobilizing and depositing these compounds on the surface of the Earth. While previous efforts have identified the importance of atmospheric leaf wax deposition in remote marine locations, the processes are not well constrained on land in temperate latitudes where lakes are common and sedimentary leaf wax hydrogen isotope values are an attractive tool for understanding past precipitation changes. This work presents results from a field study that was conducted in 2010 and 2011 at Hainich National Park, Germany in order to evaluate the quantity and sources of leaf waxes in the atmosphere. Aerosols were sampled at approximately weekly intervals inside the forest canopy, and n-alkane distributions and hydrogen isotope values were compared with those from major tree species surrounding the sampling site. Despite sampling in what was expected to be a major production center, the distribution and hydrogen isotope values of atmospheric n-alkanes bore little resemblance to those of the local vegetation. Comparison with local meteorological data and to 10-day and 36-h back air mass trajectories indicated shifting effects of winds and temperature, and that mesoscale transport processes were more important than longrange mechanisms. Back trajectories also highlighted source effects, with easterly winds coinciding with relatively lower leaf wax hydrogen isotope values from more continental regions. These results suggest that leaf wax aerosols average over spatial scales that exceed typical surface catchment areas for small lake systems, even in forested areas, yet that the area over which these compounds are derived is still relatively regional. Depositional fluxes were also estimated in order to assess the potential importance of atmospheric transport to sedimentary archives. Although difficult to constrain, these estimates suggest that atmospheric deposition may be non-negligible for lake systems in cases where inputs from rivers or surface runoff are limited. Together, these observations provide new insights on how leaf waxes from different sources are integrated during aeolian transport and the spatial scales over which these processes occur. KW - Hydrogen isotopes KW - Leaf wax KW - Aerosols KW - n-Alkanes KW - Biomarkers KW - Lakes KW - Sediments Y1 - 2016 U6 - https://doi.org/10.1016/j.gca.2016.11.018 SN - 0016-7037 SN - 1872-9533 VL - 198 SP - 299 EP - 314 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Ghasemizade, Mehdi A1 - Baroni, Gabriele A1 - Abbaspour, Karim A1 - Schirmer, Mario T1 - Combined analysis of time-varying sensitivity and identifiability indices to diagnose the response of a complex environmental model JF - Environmental modelling & software with environment data news N2 - Sensitivity and identifiability analyses are common diagnostic tools to address over-parametrization in complex environmental models, but a combined application of the two analyses is rarely conducted. In this study, we performed a temporal global sensitivity analysis using the variance-based method of Sobol’ and a temporal identifiability analysis of model parameters using the dynamic identifiability method (DYNIA). We discuss the relationship between the two analyses with a focus on parameter identification and output uncertainty reduction. The hydrological model HydroGeoSphere was used to simulate daily evapotranspiration, water content, and seepage at the lysimeter scale. We found that identifiability of a parameter does not necessarily reduce output uncertainty. It was also found that the information from the main and total effects (main Sobol' sensitivity indices) is required to allow uncertainty reduction in the model output. Overall, the study highlights the role of combined temporal diagnostic tools for improving our understanding of model behavior. KW - Temporal sensitivity KW - Identifiability KW - Preferential flow KW - HydroGeoSphere KW - Output uncertainty Y1 - 2016 U6 - https://doi.org/10.1016/j.envsoft.2016.10.011 SN - 1364-8152 SN - 1873-6726 VL - 88 SP - 22 EP - 34 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Kunnus, Kristjan A1 - Josefsson, I. A1 - Schreck, Simon Frederik A1 - Quevedo, W. A1 - Miedema, P. S. A1 - Techert, S. A1 - de Groot, F. M. F. A1 - Föhlisch, Alexander A1 - Odelius, M. A1 - Wernet, Ph. T1 - Quantifying covalent interactions with resonant inelastic soft X-ray scattering BT - case study of Ni2+ aqua complex JF - Chemical physics letters N2 - We analyze the effects of covalent interactions in Ni 2p3d resonant inelastic X-ray scattering (RIXS) spectra from aqueous Ni2+ ions and find that the relative RIXS intensities of ligand-to-metal charge-transfer final states with respect to the ligand-field final states reflect the covalent mixing between Ni 3d and water orbitals. Specifically, the experimental intensity ratio at the Ni L-3-edge allows to determine that the Ni 3d orbitals have on average 5.5% of water character. We propose that 2p3d RIXS at the Ni L-3-edge can be utilized to quantify covalency in Ni complexes without the use of external references or simulations. KW - Transition-metal ion KW - Aqueous solution KW - Covalent interaction KW - Resonant inelastic X-ray scattering KW - Ligand-field state KW - Charge-transfer state Y1 - 2016 U6 - https://doi.org/10.1016/j.cplett.2016.12.046 SN - 0009-2614 SN - 1873-4448 VL - 669 SP - 196 EP - 201 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Plener, Paul L. A1 - Zohsel, Katrin A1 - Hohm, Erika A1 - Buchmann, Arlette F. A1 - Banaschewski, T. A1 - Zimmermann, Ulrich S. A1 - Laucht, Manfred T1 - Lower cortisol level in response to a psychosocial stressor in young females with self-harm JF - Psychoneuroendocrinology N2 - Background: Self-harm is highly prevalent in adolescence, often serving an emotion regulation function. Social stressors such as bullying are associated with self-harm. The neurobiological background of the relationship between social stressors and self-harm needs to be further understood to inform prevention and therapy. Methods: Participants were members of an epidemiological cohort study. 130 female participants underwent the Trier Social Stress Test (TSST) at age 19. Of them, 21 reported a history of self-harm as assessed by the Youth Self Report. Psychiatric diagnoses were recorded. Results: Participants with a history of self-harm showed significantly lower blood cortisol levels throughout the TSST. Early psychosocial adversity did not significantly differ between groups with and without self-harm, with self-harming participants reporting more childhood adversities. Conclusion: These results add to the limited field of studies showing an altered HPA axis activity in females with self-harm. Future studies need to address the causal mechanisms behind this association. KW - Self-harm KW - Trier Social Stress Test KW - TSST KW - Cortisol KW - Nonsuicidal self-injury Y1 - 2016 U6 - https://doi.org/10.1016/j.psyneuen.2016.11.009 SN - 0306-4530 VL - 76 SP - 84 EP - 87 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Fer, Istem A1 - Tietjen, Britta A1 - Jeltsch, Florian A1 - Trauth, Martin H. T1 - Modelling vegetation change during Late Cenozoic uplift of the East African plateaus JF - Palaeogeography, palaeoclimatology, palaeoecology : an international journal for the geo-sciences N2 - The present-day vegetation in the tropics is mainly characterized by forests worldwide except in tropical East Africa, where forests only occur as patches at the coast and in the uplands. These forest patches result from the peculiar aridity that is linked to the uplift of the region during the Late Cenozoic. The Late Cenozoic vegetation history of East Africa is of particular interest as it has set the scene for the contemporary events in mammal and hominin evolution. In this study, we investigate the conditions under which these forest patches could have been connected, and a previous continuous forest belt could have extended and fragmented. We apply a dynamic vegetation model with a set of climatic scenarios in which we systematically alter the present-day environmental conditions such that they would be more favourable for a continuous forest belt in tropical East Africa. We consider varying environmental factors, namely temperature, precipitation and atmospheric CO2 concentrations. Our results show that all of these variables play a significant role in supporting the forest biomes and a continuous forest belt could have occurred under certain combinations of these settings. With our current knowledge of the palaeoenvironmental history of East Africa, it is likely that the region hosted these conditions during the Late Cenozoic. Recent improvements on environmental hypotheses of hominin evolution highlight the role of periods of short and extreme climate variability during the Late Cenozoic specific to East Africa in driving evolution. Our results elucidate how the forest biomes of East Africa can appear and disappear under fluctuating environmental conditions and demonstrate how this climate variability might be recognized on the biosphere level. KW - Dynamic vegetation models KW - Palaeovegetation KW - Evolution KW - Late Cenozoic KW - East Africa KW - Climate change Y1 - 2016 U6 - https://doi.org/10.1016/j.palaeo.2016.04.007 SN - 0031-0182 SN - 1872-616X VL - 467 SP - 120 EP - 130 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Vandewal, Koen A1 - Benduhn, Johannes A1 - Schellhammer, Karl Sebastian A1 - Vangerven, Tim A1 - Rückert, Janna E. A1 - Piersimoni, Fortunato A1 - Scholz, Reinhard A1 - Zeika, Olaf A1 - Fan, Yeli A1 - Barlow, Stephen A1 - Neher, Dieter A1 - Marder, Seth R. A1 - Manca, Jean A1 - Spoltore, Donato A1 - Cuniberti, Gianaurelio A1 - Ortmann, Frank T1 - Absorption Tails of Donor BT - C-60 Blends Provide Insight into Thermally Activated Charge-Transfer Processes and Polaron Relaxation JF - Journal of the American Chemical Society N2 - In disordered organic semiconductors, the transfer of a rather localized charge carrier from one site to another triggers a deformation of the molecular structure quantified by the intramolecular relaxation energy. A similar structural relaxation occurs upon population of intermolecular charge-transfer (CT) states formed at organic electron donor (D)-acceptor (A) interfaces. Weak CT absorption bands for D A complexes occur at photon energies below the optical gaps of both the donors and the C-60 acceptor as a result of optical transitions from the neutral ground state to the ionic CT state. In this work, we show that temperature-activated intramolecular vibrations of the ground state play a major role in determining the line shape of such CT absorption bands. This allows us to extract values for the relaxation energy related to the geometry change from neutral to ionic CT complexes. Experimental values for the relaxation energies of 20 D:C-60 CT complexes correlate with values calculated within density functional theory. These results provide an experimental method for determining the polaron relaxation energy in solid-state organic D-A blends and show the importance of a reduced relaxation energy, which we introduce to characterize thermally activated CT processes. Y1 - 2017 U6 - https://doi.org/10.1021/jacs.6b12857 SN - 0002-7863 VL - 139 IS - 4 SP - 1699 EP - 1704 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Zohsel, Katrin A1 - Holz, Nathalie E. A1 - Hohm, Erika A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Fewer self-reported depressive symptoms in young adults exposed to maternal depressed mood during pregnancy JF - Journal of Affective Disorders N2 - Background: Depressed mood is prevalent during pregnancy, with accumulating evidence suggesting an impact on developmental outcome in the offspring. However, the long-term effects of prenatal maternal depression regarding internalizing psychopathology in the offspring are as yet unclear. Results: In n=85 young adults exposed to prenatal maternal depressed mood, no significantly higher risk for a diagnosis of depressive disorder was observed. However, they reported significantly lower levels of depressive symptoms. This association was especially pronounced when prenatal maternal depressed mood was present during the first trimester of pregnancy and when maternal mood was depressed pre- as well as postnatally. At an uncorrected level only, prenatal maternal depressed mood was associated with decreased amygdala volume. Limitations: Prenatal maternal depressed mood was not assessed during pregnancy, but shortly after childbirth. No diagnoses of maternal clinical depression during pregnancy were available. Conclusions: Self-reported depressive symptoms do not imply increased, but rather decreased symptom levels in young adults who were exposed to prenatal maternal depressed mood. A long-term perspective may be important when considering consequences of prenatal risk factors. Y1 - 2016 U6 - https://doi.org/10.1016/j.jad.2016.08.059 SN - 0165-0327 SN - 1573-2517 VL - 209 SP - 155 EP - 162 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Garcin, Yannick A1 - Schildgen, Taylor F. A1 - Acosta, Veronica Torres A1 - Melnick, Daniel A1 - Guillemoteau, Julien A1 - Willenbring, Jane A1 - Strecker, Manfred T1 - Short-lived increase in erosion during the African Humid Period BT - evidence from the northern Kenya Rift JF - Earth & planetary science letters N2 - The African Humid Period (AHP) between similar to 15 and 5.5 cal. kyr BP caused major environmental change in East Africa, including filling of the Suguta Valley in the northern Kenya Rift with an extensive (similar to 2150 km(2)), deep (similar to 300 m) lake. Interfingering fluvio-lacustrine deposits of the Baragoi paleo-delta provide insights into the lake-level history and how erosion rates changed during this time, as revealed by delta-volume estimates and the concentration of cosmogenic Be-10 in fluvial sand. Erosion rates derived from delta-volume estimates range from 0.019 to 0.03 mm yr(-1). Be-10-derived paleo-erosion rates at similar to 11.8 cal. kyr BP ranged from 0.035 to 0.086 mm yr(-1), and were 2.7 to 6.6 times faster than at present. In contrast, at similar to 8.7 cal. kyr BP, erosion rates were only 1.8 times faster than at present. Because Be-10-derived erosion rates integrate over several millennia; we modeled the erosion-rate history that best explains the 10Be data using established non-linear equations that describe in situ cosmogenic isotope production and decay. Two models with different temporal constraints (15-6.7 and 12-6.7 kyr) suggest erosion rates that were 25 to 300 times higher than the initial erosion rate (pre-delta formation). That pulse of high erosion rates was short (similar to 4 kyr or less) and must have been followed by a rapid decrease in rates while climate remained humid to reach the modern Be-10-based erosion rate of,similar to 0.013 mm yr(-1). Our simulations also flag the two highest Be-10-derived erosion rates at 11.8 kyr BP related to nonuniform catchment erosion. These changes in erosion rates and processes during the AHP may reflect a strong increase in precipitation, runoff, and erosivity at the arid-to-humid transition either at 15 or similar to 12 cal. kyr BP, before the landscape stabilized again, possibly due to increased soil production and denser vegetation. KW - northern Kenya Rift KW - Baragoi KW - paleo-delta KW - African Humid Period KW - erosion KW - Be-10 Y1 - 2017 U6 - https://doi.org/10.1016/j.epsl.2016.11.017 SN - 0012-821X SN - 1385-013X VL - 459 SP - 58 EP - 69 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Becker, Christian A1 - Schenkel, Alexander A1 - Szabo, Richard J. T1 - Differential cohomology and locally covariant quantum field theory JF - Reviews in Mathematical Physics N2 - We study differential cohomology on categories of globally hyperbolic Lorentzian manifolds. The Lorentzian metric allows us to define a natural transformation whose kernel generalizes Maxwell's equations and fits into a restriction of the fundamental exact sequences of differential cohomology. We consider smooth Pontryagin duals of differential cohomology groups, which are subgroups of the character groups. We prove that these groups fit into smooth duals of the fundamental exact sequences of differential cohomology and equip them with a natural presymplectic structure derived from a generalized Maxwell Lagrangian. The resulting presymplectic Abelian groups are quantized using the CCR-functor, which yields a covariant functor from our categories of globally hyperbolic Lorentzian manifolds to the category of C∗-algebras. We prove that this functor satisfies the causality and time-slice axioms of locally covariant quantum field theory, but that it violates the locality axiom. We show that this violation is precisely due to the fact that our functor has topological subfunctors describing the Pontryagin duals of certain singular cohomology groups. As a byproduct, we develop a Fréchet–Lie group structure on differential cohomology groups. KW - Algebraic quantum field theory KW - generalized Abelian gauge theory KW - differential cohomology Y1 - 2017 U6 - https://doi.org/10.1142/S0129055X17500039 SN - 0129-055X SN - 1793-6659 VL - 29 IS - 1 PB - World Scientific CY - Singapore ER - TY - JOUR A1 - Bauer, Daniel A1 - Werth, Felix A1 - Ha An Nguyen, A1 - Kiecker, Felix A1 - Eberle, Jürgen T1 - Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells JF - Cell death & disease N2 - Inhibition of MAP kinase pathways by selective BRAF inhibitors, such as vemurafenib and dabrafenib, have evolved as key therapies of BRAF-mutated melanoma. However, tumor relapse and therapy resistance have remained as major problems, which may be addressed by combination with other pathway inhibitors. Here we identified the potassium channel inhibitor TRAM-34 as highly effective in combination with vemurafenib. Thus apoptosis was significantly enhanced and cell viability was decreased. The combination vemurafenib/TRAM-34 was also effective in vemurafenib-resistant cells, suggesting that acquired resistance may be overcome. Vemurafenib decreased ERK phosphorylation, suppressed antiapoptotic Mcl-1 and enhanced proapoptotic Puma and Bim. The combination resulted in enhancement of proapoptotic pathways as caspase-3 and loss of mitochondrial membrane potential. Indicating a special mechanism of vemurafenib-induced apoptosis, we found strong enhancement of intracellular ROS levels already at 1 h of treatment. The critical role of ROS was demonstrated by the antioxidant vitamin E (alpha-tocopherol), which decreased intracellular ROS as well as apoptosis. Also caspase activation and loss of mitochondrial membrane potential were suppressed, proving ROS as an upstream effect. Thus ROS represents an initial and independent apoptosis pathway in melanoma cells that is of particular importance for vemurafenib and its combination with TRAM-34. Y1 - 2017 U6 - https://doi.org/10.1038/cddis.2017.6 SN - 2041-4889 VL - 8 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Saini, Jeetendra A1 - Guenther, Franziska A1 - Aichner, Bernhard A1 - Mischke, Steffen A1 - Herzschuh, Ulrike A1 - Zhang, Chengjun A1 - Maeusbacher, Roland A1 - Gleixner, Gerd T1 - Climate variability in the past similar to 19,000 yr in NE Tibetan Plateau inferred from biomarker and stable isotope records of Lake Donggi Cona JF - Quaternary science reviews : the international multidisciplinary research and review journal N2 - We investigated 4.84-m-long sediment record spanning over the Late Glacial and Holocene from Lake Donggi Cona to be able to reconstruct circulation pattern on the Tibetan Plateau (TP). Presently, Lake Donggi Cona is located at the boundaries of Westerlies and Asian monsoon circulations in the northeastern TP. However, the exact timing and stimulating mechanisms for climatic changes and monsoon shifts in this region are still debated. We used a 19-ka-long stable isotope record of sedimentary n-alkanes to address this discrepancy by providing insights into paleohydrological conditions. The SD of nC(23) is influenced by lake water evaporation; the BD. values of sedimentary nC(29) are mainly controlled by moisture source and temperature changes. Long-chain n-alkanes dominate over the core whereas three mean clusters (i.e. microbial, aquatic and terrestrial) can be inferred. Multi-proxies suggest five major episodes in the history of Lake Donggi Cona. The Lake Donggi Cona record indicates that the Late Glacial(18.4-14.8 cal ka BP) was dominated by low productivity of mainly microbial and aquatic organisms. Relatively low delta D values suggest low temperatures and moist conditions eventually caused by stronger Westerlies, winter monsoon and melt-water influence. Likely, the shift (similar to 17.9 cal ka BP) from microbial to enhanced aquatic input suggests either a change from deep to shallow water lake or a break in local stratification. Between 14.8 and 13.0 cal ka BP, variable climatic conditions prevailed. Although the Westerlies weekend, the increase in temperature enhanced the permafrost and snow melting (displayed by a high sedimentary accumulation rate). Higher delta D values indicate increasingly arid conditions with higher temperatures which eventually lead to high evaporative conditions and lowest lake levels. Low vegetation cover and high erosion rates led to high sediment accumulation resulting in stratification followed by anoxia in the terminal lake. From 13.0 to 9.2 cal ka BP, lowered values of 813 along with high contents of terrestrial organic matter marked the early-Holocene warming indicating a further strengthening of summer precipitation and higher lake levels. A cooling trend was observed in the mid-Holocene between 9.2 and 3.0 cal ka BP accompanied by higher moisture availability (displayed by lowered SD values) caused by reduced evaporative conditions due to a drop in temperature and recovering Westerlies. After 3.0 cal ka BP, a decrease in lake productivity and cold and semi-arid conditions prevailed suggesting lower lake levels and reduced moisture from recycled air masses and Westerlies. We propose that the summer monsoon was the predominant moisture source during the Belling-Allered warm complex and early -Holocene followed by Westerlies in mid-to-late Holocene period. Stable carbon isotope values-32%o indicate the absence of C-4 -type vegetation in the region contradicting with their presence in the Lake Qinghai record. The 81) record from lake Donggi Cona highlights the importance of the interplay between Westerlies and summer monsoon circulation at this location, which is highly dynamic in northeastern plateau compared to the North Atlantic circulation and insolation changes. Consequently lake Donggi Cona might be an important anchor point for environmental reconstructions on the Tibetan Plateau. (C) 2017 The Authors. Published by Elsevier Ltd. KW - n-alkanes KW - Hydrogen isotopes (delta D) KW - Carbon isotopes (delta C-13) KW - Carbon preference index (CPI) KW - Westerlies KW - Continental air masses KW - Precipitation KW - Late Glacial and Holocene Y1 - 2017 U6 - https://doi.org/10.1016/j.quascirev.2016.12.023 SN - 0277-3791 VL - 157 SP - 129 EP - 140 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Drosselmeyer, Julia A1 - Jacob, Louis A1 - Rathmann, Wolfgang A1 - Rapp, Michael A. A1 - Kostev, Karel T1 - Depression risk in patients with late-onset rheumatoid arthritis in Germany JF - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation N2 - The goal of this study was to determine the prevalence of depression and its risk factors in patients with late-onset rheumatoid arthritis (RA) treated in German primary care practices. Longitudinal data from general practices (n=1072) throughout Germany were analyzed. Individuals initially diagnosed with RA (2009-2013) were identified, and 7301 patients were included and matched (1:1) to 7301 controls. The primary outcome measure was the initial diagnosis of depression within 5 years after the index date in patients with and without RA. Cox proportional hazards models were used to adjust for confounders. The mean age was 72.2 years (SD: 7.6 years). A total of 34.9 % of patients were men. Depression diagnoses were present in 22.0 % of the RA group and 14.3 % of the control group after a 5-year follow-up period (p < 0.001). In the multivariate regression model, RA was a strong risk factor for the development of depression (HR: 1.55, p < 0.001). There was significant interaction of RA and diagnosed inflammatory polyarthropathies (IP) (RA*IP interaction: p < 0.001). Furthermore, dementia, cancer, osteoporosis, hypertension, and diabetes were associated with a higher risk of developing depression (p values < 0.001). The risk of depression is significantly higher in patients with late-onset RA than in patients without RA for subjects treated in primary care practices in Germany. RA patients should be screened routinely for depression in order to ensure improved treatment and management. KW - Late-onset rheumatoid arthritis KW - Depression KW - Primary care KW - Risk factors KW - Germany Y1 - 2016 U6 - https://doi.org/10.1007/s11136-016-1387-2 SN - 0962-9343 SN - 1573-2649 VL - 26 IS - 2 SP - 437 EP - 443 PB - Springer CY - Dordrecht ER - TY - GEN A1 - Wang, Yongbo A1 - Herzschuh, Ulrike A1 - Liu, Xingqi A1 - Korup, Oliver A1 - Diekmann, Bernhard T1 - Reply to Chong Xu’s comment on: Wang, Yongbo; Herzschuh, Ulrike; Liu, Xingqi; Korup, Oliver; Diekmann, Bernhard: A high-resolution sedimentary archive from landslide-dammed Lake Mengda, north-eastern Tibetan Plateau. - Journal of Paleolimnology. - 51 (2014), S. 303 - 312 T2 - Journal of paleolimnolog Y1 - 2016 U6 - https://doi.org/10.1007/s10933-016-9937-8 SN - 0921-2728 SN - 1573-0417 VL - 57 SP - 163 EP - 164 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Dimitrova, Ilinka A1 - Fernandes, Vitor H. A1 - Koppitz, Jörg T1 - A note on generators of the endomorphism semigroup of an infinite countable chain JF - Journal of Algebra and its Applications N2 - In this note, we consider the semigroup O(X) of all order endomorphisms of an infinite chain X and the subset J of O(X) of all transformations alpha such that vertical bar Im(alpha)vertical bar = vertical bar X vertical bar. For an infinite countable chain X, we give a necessary and sufficient condition on X for O(X) = < J > to hold. We also present a sufficient condition on X for O(X) = < J > to hold, for an arbitrary infinite chain X. KW - Infinite chain KW - endomorphism semigroup KW - generators KW - relative rank Y1 - 2016 U6 - https://doi.org/10.1142/S0219498817500311 SN - 0219-4988 SN - 1793-6829 VL - 16 IS - 2 PB - World Scientific CY - Singapore ER - TY - JOUR A1 - Kozicka, Marta A1 - Kalkuhl, Matthias A1 - Brockhaus, Jan T1 - Food Grain Policies in India and their Implications for Stocks and Fiscal Costs BT - a Dynamic Partial Equilibrium Analysis JF - Journal of Agricultural Economics N2 - We analyse current and possible future reforms of the Indian food policies for the most important staple grains, wheat and rice, within a two-commodity dynamic partial equilibrium model with stochastic shocks. The model is empirically grounded and reproduces past values well. It uses a new reduced-form approach to capture private storage dynamics. We evaluate the implementation of the National Food Security Act (NFSA) under several policy measures with the current regime as well as two scenarios with a regime change - implementation of cash transfers and deficiency payments. Implications for market fundamentals and fiscal costs are simulated in the medium term - until 2020/21. The NFSA puts a high pressure on fiscal costs and public stocks. Relying on imports with low support prices results in low fiscal costs and stable, but higher domestic and international prices, and a high risk of zero stocks. A policy strategy to manipulate procurement prices in order to maintain public stocks close to the norms leads to slightly higher fiscal costs with lower, but more volatile prices. The highest domestic price volatility occurs under a strategy which uses export bans in order to maintain sufficient public stocks. A cash-based regime can bring considerable savings and curb fiscal costs, particularly if targeted to the poor, and would leave sufficient stocks due to higher private stocks. KW - Fiscal costs KW - food grain policies KW - grain storage KW - India KW - NFSA KW - reforms Y1 - 2017 U6 - https://doi.org/10.1111/1477-9552.12176 SN - 0021-857X SN - 1477-9552 VL - 68 IS - 1 SP - 98 EP - 122 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Reil, Daniela A1 - Imholt, Christian A1 - Rosenfeld, Ulrike A1 - Drewes, Stephan A1 - Fischer, S. A1 - Heuser, Emil A1 - Petraityte-Burneikiene, Rasa A1 - Ulrich, R. G. A1 - Jacob, J. T1 - Validation of the Puumala virus rapid field test for bank voles in Germany JF - Epidemiology and infection N2 - Puumala virus (PUUV) causes many human infections in large parts of Europe and can lead to mild to moderate disease. The bank vole (Myodes glareolus) is the only reservoir of PUUV in Central Europe. A commercial PUUV rapid field test for rodents was validated for bank-vole blood samples collected in two PUUV-endemic regions in Germany (North Rhine-Westphalia and Baden-Wurttemberg). A comparison of the results of the rapid field test and standard ELISAs indicated a test efficacy of 93-95%, largely independent of the origin of the antigens used in the ELISA. In ELISAs, reactivity for the German PUUV strain was higher compared to the Swedish strain but not compared to the Finnish strain, which was used for the rapid field test. In conclusion, the use of the rapid field test can facilitate short-term estimation of PUUV seroprevalence in bank-vole populations in Germany and can aid in assessing human PUUV infection risk. KW - Antibody detection KW - early warning KW - Europe KW - hantavirus KW - Myodes glareolus Y1 - 2017 U6 - https://doi.org/10.1017/S0950268816002557 SN - 0950-2688 SN - 1469-4409 VL - 145 IS - 3 SP - 434 EP - 439 PB - Cambridge Univ. Press CY - New York ER - TY - JOUR A1 - Castino, Fabiana A1 - Bookhagen, Bodo A1 - Strecker, Manfred T1 - Rainfall variability and trends of the past six decades (1950-2014) in the subtropical NW Argentine Andes JF - Climate dynamics : observational, theoretical and computational research on the climate system N2 - The eastern flanks of the Central Andes are characterized by deep convection, exposing them to hydrometeorological extreme events, often resulting in floods and a variety of mass movements. We assessed the spatiotemporal pattern of rainfall trends and the changes in the magnitude and frequency of extreme events (ae95th percentile) along an E-W traverse across the southern Central Andes using rain-gauge and high-resolution gridded datasets (CPC-uni and TRMM 3B42 V7). We generated different climate indices and made three key observations: (1) an increase of the annual rainfall has occurred at the transition between low (< 0.5 km) and intermediate (0.5-3 km) elevations between 1950 and 2014. Also, rainfall increases during the wet season and, to a lesser degree, decreases during the dry season. Increasing trends in annual total amounts characterize the period 1979-2014 in the arid, high-elevation southern Andean Plateau, whereas trend reversals with decreasing annual total amounts were found at low elevations. (2) For all analyzed periods, we observed small or no changes in the median values of the rainfall-frequency distribution, but significant trends with intensification or attenuation in the 95th percentile. (3) In the southern Andean Plateau, extreme rainfall events exhibit trends towards increasing magnitude and, to a lesser degree, frequency during the wet season, at least since 1979. Our analysis revealed that low (< 0.5 km), intermediate (0.5-3 km), and high-elevation (> 3 km) areas respond differently to changing climate conditions, and the transition zone between low and intermediate elevations is characterized by the most significant changes. KW - Extreme rainfall KW - South American Monsoon System KW - Central Andes KW - Quantile regression KW - Rain gauges KW - CPC-uni KW - TRMM KW - Orographic barrier Y1 - 2017 U6 - https://doi.org/10.1007/s00382-016-3127-2 SN - 0930-7575 SN - 1432-0894 VL - 48 SP - 1049 EP - 1067 PB - Springer CY - New York ER - TY - JOUR A1 - Henkel, Carsten T1 - Nanoscale Thermal Transfer BT - an Invitation to Fluctuation Electrodynamics JF - Zeitschrift für Naturforschung A N2 - An electromagnetic theory of thermal radiation is outlined, based on the fluctuation electrodynamics of Rytov and co-workers. We discuss the basic concepts and the status of different approximations. The physical content is illustrated with a few examples on near-field heat transfer. KW - Heat Transfer KW - Near-Field Optics KW - Thermal Radiation Y1 - 2017 U6 - https://doi.org/10.1515/zna-2016-0372 SN - 0932-0784 SN - 1865-7109 VL - 72 IS - 2 SP - 99 EP - 108 PB - De Gruyter CY - Berlin ER - TY - JOUR A1 - Pan, Jinger A1 - Kong, Yan A1 - Song, Shuang A1 - McBride, Catherine A1 - Liu, Hongyun A1 - Shu, Hua T1 - Socioeconomic status, parent report of children’s early language skills, and late literacy skills BT - a long term follow-up study among Chinese children JF - Reading and writing : an interdisciplinary journal N2 - Previous research on the longitudinal prediction of literacy development has focused mainly on the relationship between early cognitive/language skills and late literacy skills. The present study aimed to test the reliability of a number of measures reported by parents as compared to measuring cognitive and language skills in predicting subsequent reading achievement. Two hundred sixty-two Chinese children were administered four cognitive and language skills over three years at the preliterate stage. Additional information on children’s family socioeconomic status (SES), children’s early language skills, familial reading performance and habits, and familial handedness based on the observations of parents was collected. Performance on these variables in relation to subsequent literacy skills at 11 years of age was examined. SES and children’s early language skills significantly predicted subsequent literacy skills. Even with a number of cognitive and language skills statistically controlled, parental reports of children’s early language skills still contributed to reading comprehension. Poor readers defined at 11 years of age had lagged behind in early language skills, as well as family reading performance and habits, as compared to typically developing readers. These findings suggest that SES and parental estimates of children’s early language skills are useful for predicting children’s subsequent reading achievement. KW - SES KW - Parent questionnaire KW - Early language skills KW - Familial risk KW - Chinese reading Y1 - 2017 U6 - https://doi.org/10.1007/s11145-016-9682-4 SN - 0922-4777 SN - 1573-0905 VL - 30 SP - 401 EP - 416 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Stillfried, Milena A1 - Fickel, Jörns A1 - Börner, Konstantin A1 - Wittstatt, Ulrich A1 - Heddergott, Mike A1 - Ortmann, Sylvia A1 - Kramer-Schadt, Stephanie A1 - Frantz, Alain C. T1 - Do cities represent sources, sinks or isolated islands for urban wild boar population structure? JF - Journal of applied ecology : an official journal of the British Ecological Society KW - baps KW - Berlin KW - diyabc KW - human-wildlife conflict KW - hunting KW - microsatellites KW - movement barrier KW - source-sink dynamics KW - structure KW - urban ecology Y1 - 2017 U6 - https://doi.org/10.1111/1365-2664.12756 SN - 0021-8901 SN - 1365-2664 VL - 54 IS - 1 SP - 272 EP - 281 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Münch, Florentin T1 - Remarks on curvature dimension conditions on graphs JF - Calculus of variations and partial differential equations N2 - We show a connection between the CDE′ inequality introduced in Horn et al. (Volume doubling, Poincaré inequality and Gaussian heat kernel estimate for nonnegative curvature graphs. arXiv:1411.5087v2, 2014) and the CDψ inequality established in Münch (Li–Yau inequality on finite graphs via non-linear curvature dimension conditions. arXiv:1412.3340v1, 2014). In particular, we introduce a CDφψ inequality as a slight generalization of CDψ which turns out to be equivalent to CDE′ with appropriate choices of φ and ψ. We use this to prove that the CDE′ inequality implies the classical CD inequality on graphs, and that the CDE′ inequality with curvature bound zero holds on Ricci-flat graphs. Y1 - 2017 U6 - https://doi.org/10.1007/s00526-016-1104-6 SN - 0944-2669 SN - 1432-0835 VL - 56 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Reike, Dennis A1 - Schwarz, Wolfgang T1 - Exploring the origin of the number-size congruency effect BT - sensitivity or response bias? JF - Attention, perception, & psychophysics : AP&P ; a journal of the Psychonomic Society, Inc. N2 - Physical size modulates the efficiency of digit comparison, depending on whether the relation of numerical magnitude and physical size is congruent or incongruent (Besner & Coltheart, Neuropsychologia, 17, 467–472, 1979), the number-size congruency effect (NSCE). In addition, Henik and Tzelgov (Memory & Cognition, 10, 389–395, 1982) first reported an NSCE for the reverse task of comparing the physical size of digits such that the numerical magnitude of digits modulated the time required to compare their physical sizes. Does the NSCE in physical comparisons simply reflect a number-mediated bias mechanism related to making decisions and selecting responses about the digit’s sizes? Alternatively, or in addition, the NSCE might indicate a true increase in the ability to discriminate small and large font sizes when these sizes are congruent with the digit’s symbolic numerical meaning, over and above response bias effects. We present a new research design that permits us to apply signal detection theory to a task that required observers to judge the physical size of digits. Our results clearly demonstrate that the NSCE cannot be reduced to mere response bias effects, and that genuine sensitivity gains for congruent number-size pairings contribute to the NSCE. KW - Numerical cognition KW - Number-size congruity effect KW - Signal detection theory Y1 - 2017 U6 - https://doi.org/10.3758/s13414-016-1267-4 SN - 1943-3921 SN - 1943-393X VL - 79 SP - 383 EP - 388 PB - Springer CY - New York ER - TY - JOUR A1 - Holz, Nathalie E. A1 - Boecker-Schlier, Regina A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Jennen-Steinmetz, Christine A1 - Baumeister, Sarah A1 - Plichta, Michael M. A1 - Cattrell, Anna A1 - Schumann, Gunter A1 - Esser, Günter A1 - Schmidt, Martin A1 - Buitelaar, Jan A1 - Meyer-Lindenberg, Andreas A1 - Banaschewski, Tobias A1 - Brandeis, Daniel A1 - Laucht, Manfred T1 - Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder JF - Frontiers in human neuroscience N2 - Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth. CFA during childhood was determined using a standardized parent interview. Disruptive behaviors and CD diagnoses during childhood and adolescence were obtained by diagnostic interview (2–19 years), temperamental reward dependence was assessed by questionnaire (15 and 19 years). CFA predicted increased CD and amygdala volume. Both exposure to CFA and CD were associated with a decreased VS response during reward anticipation and blunted amygdala activity during face-matching. CD mediated the effect of CFA on brain activity. Temperamental reward dependence was negatively correlated with CFA and CD and positively with VS activity. These findings underline the detrimental effects of CFA on the offspring's affective processing and support the importance of early postnatal intervention programs aiming to reduce childhood adversity factors. KW - childhood adversity KW - conduct disorder KW - amygdala KW - ventral striatum KW - fMRI Y1 - 2016 U6 - https://doi.org/10.1093/scan/nsw120 SN - 1749-5016 SN - 1749-5024 VL - 12 IS - 2 SP - 261 EP - 272 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Siska, Veronika A1 - Jones, Eppie Ruth A1 - Jeon, Sungwon A1 - Bhak, Youngjune A1 - Kim, Hak-Min A1 - Cho, Yun Sung A1 - Kim, Hyunho A1 - Lee, Kyusang A1 - Veselovskaya, Elizaveta A1 - Balueva, Tatiana A1 - Gallego-Llorente, Marcos A1 - Hofreiter, Michael A1 - Bradley, Daniel G. A1 - Eriksson, Anders A1 - Pinhasi, Ron A1 - Bhak, Jong A1 - Manica, Andrea T1 - Genome-wide data from two early Neolithic East Asian individuals dating to 7700 years ago JF - Science Advances N2 - Ancient genomes have revolutionized our understanding of Holocene prehistory and, particularly, the Neolithic transition in western Eurasia. In contrast, East Asia has so far received little attention, despite representing a core region at which the Neolithic transition took place independently ~3 millennia after its onset in the Near East. We report genome-wide data from two hunter-gatherers from Devil’s Gate, an early Neolithic cave site (dated to ~7.7 thousand years ago) located in East Asia, on the border between Russia and Korea. Both of these individuals are genetically most similar to geographically close modern populations from the Amur Basin, all speaking Tungusic languages, and, in particular, to the Ulchi. The similarity to nearby modern populations and the low levels of additional genetic material in the Ulchi imply a high level of genetic continuity in this region during the Holocene, a pattern that markedly contrasts with that reported for Europe. Y1 - 2017 U6 - https://doi.org/10.1126/sciadv.1601877 SN - 2375-2548 VL - 3 IS - 2 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - JOUR A1 - Ganghof, Steffen T1 - The Empirical Uses of Theoretical Models BT - the Case of Veto Player Theory JF - Political studies review N2 - Veto player theory is a powerful approach to comparative politics. This article argues that the debate about its explanatory success would benefit from more systematic distinctions. The theory not only comes in different theoretical variants, it is also used in radically different ways empirically. Starting from recent debates about the ‘testing’ of theoretical models, the article distinguishes five ways in which theoretical models can be used empirically: contrastive, axiomatic, exploratory, presumptive and modular. The typology is applied to veto player theory and illustrated with exemplary studies and debates. The article concludes that each type raises different questions that should be answered in individual studies. Moreover, while veto player theory has an excellent track record on four empirical uses, the picture on its contrastive use is far more nuanced. More explicitly contrastive testing of the theory is desirable. KW - veto player theory KW - theory testing KW - empirical implications of theoretical models KW - contrastive empiricism Y1 - 2017 U6 - https://doi.org/10.1111/1478-9302.12098 SN - 1478-9299 SN - 1478-9302 VL - 15 SP - 49 EP - 59 PB - Sage Publ. CY - London ER - TY - JOUR A1 - Ruelens, Philip A1 - Zhang, Zhicheng A1 - van Mourik, Hilda A1 - Maere, Steven A1 - Kaufmann, Kerstin A1 - Geuten, Koen T1 - The Origin of Floral Organ Identity Quartets JF - The plant cell N2 - The origin of flowers has puzzled plant biologists ever since Darwin referred to their sudden appearance in the fossil record as an abominable mystery. Flowers are considered to be an assembly of protective, attractive, and reproductive male and female leaf-like organs. Their origin cannot be understood by a morphological comparison to gymnosperms, their closest relatives, which develop separate male or female cones. Despite these morphological differences, gymnosperms and angiosperms possess a similar genetic toolbox consisting of phylogenetically related MADS domain proteins. Using ancestral MADS domain protein reconstruction, we trace the evolution of organ identity quartets along the stem lineage of crown angiosperms. We provide evidence that current floral quartets specifying male organ identity, which consist of four types of subunits, evolved from ancestral complexes of two types of subunits through gene duplication and integration of SEPALLATA proteins just before the origin of flowering plants. Our results suggest that protein interaction changes underlying this compositional shift were the result of a gradual and reversible evolutionary trajectory. Modeling shows that such compositional changes may have facilitated the evolution of the perfect, bisexual flower. Y1 - 2017 U6 - https://doi.org/10.1105/tpc.16.00366 SN - 1040-4651 SN - 1532-298X VL - 29 IS - 2 SP - 229 EP - 242 PB - American Society of Plant Physiologists CY - Rockville ER - TY - JOUR A1 - Tronicke, Jens A1 - Paasche, Hendrik T1 - Integrated interpretation of 2D ground-penetrating radar, P-, and S-wave velocity models in terms of petrophysical properties BT - assessing uncertainties related to data inversion and petrophysical relations JF - Interpretation : a journal of subsurface characterization N2 - Near-surface geophysical techniques are extensively used in a variety of engineering, environmental, geologic, and hydrologic applications. While many of these applications ask for detailed, quantitative models of selected material properties, geophysical data are increasingly used to estimate such target properties. Typically, this estimation procedure relies on a two-step workflow including (1) the inversion of geophysical data and (2) the petrophysical translation of the inverted parameter models into the target properties. Standard deterministic implementations of such a quantitative interpretation result in a single best-estimate model, often without considering and propagating the uncertainties related to the two steps. We address this problem by using a rather novel, particle-swarm-based global joint strategy for data inversion and by implementing Monte Carlo procedures for petrophysical property estimation. We apply our proposed workflow to crosshole ground-penetrating radar, P-, and S-wave data sets collected at a well-constrained test site for a detailed geotechnical characterization of unconsolidated sands. For joint traveltime inversion, the chosen global approach results in ensembles of acceptable velocity models, which are analyzed to appraise inversion-related uncertainties. Subsequently, the entire ensembles of inverted velocity models are considered to estimate selected petrophysical properties including porosity, bulk density, and elastic moduli via well-established petrophysical relations implemented in a Monte Carlo framework. Our results illustrate the potential benefit of such an advanced interpretation strategy; i.e., the proposed workflow allows to study how uncertainties propagate into the finally estimated property models, while concurrently we are able to study the impact of uncertainties in the used petrophysical relations (e.g., the influence of uncertain, user-specified parameters). We conclude that such statistical approaches for the quantitative interpretation of geophysical data can be easily extended and adapted to other applications and geophysical methods and might be an important step toward increasing the popularity and acceptance of geophysical tools in engineering practice. Y1 - 2017 U6 - https://doi.org/10.1190/INT-2016-0081.1 SN - 2324-8858 SN - 2324-8866 VL - 5 IS - 1 SP - T121 EP - T130 PB - Society of Exploration Geophysicists CY - Tulsa ER -