TY  - JOUR
A1  - Chupeerach, Chaowanee
A1  - Harnroongroj, Talabporn
A1  - Phonrat, Benjaluck
A1  - Tungtrongchitr, Anchalee
A1  - Schweigert, Florian J.
A1  - Tungtrongchitr, Rungsunn
A1  - Preutthipan, Sangchai
T1  - Decreased retinol transport proteins in thai post-menopausal women with Osteporosis
JF  - The Southeast Asian journal of tropical medicine and public health : official publication of the SEAMEO Regional Tropical Medicine and Public Health Project (TROPMED)
N2  - High vitamin A ingestion or high serum retinol have been postulated to increase the risk of fractures and osteoporosis by reduced bone mineral density (BMD). Retinol is carried and transported to the tissues bound to retinol binding protein 4 (RBP4) and transthyretin (TTR). The relationships between retinol, retinol transport protein, retinol binding protein 4 (RBP4) and transthyretin (TTR) and BMD and osteoporosis are unclear. To examine the association between retinol and RBP4 and TTR and osteoporosis, 73 osteoporotic and 71 normal Thai postmenopausal women were studied. RBP4 and retinol levels did not differ between the groups. Serum TTR was significantly higher in control than osteoporotic subjects (89.47 and 144.53 mu g/ml, respectively, p=0.003, Mann-Whitney U test). TTR was positively correlated with BMD at several sites, such as the total radius bone (r=0.172, p=0.008, Spearman rank test). Osteoporosis risk was analyzed with binary logistic regression. Lean elderly Thais with lower TTR levels had a higher risk of osteoporosis. RBP4 and retinol levels had no relationship with disease status among Thai post-menopausal women. These results suggest calcium, minerals, vitamins and the retinol transport protein, transthyretin may be involved in the pathogenesis of osteoporosis.
KW  - transthyretin
KW  - vitamin A
KW  - retinol binding protein 4
KW  - post-menopausal Thai women
Y1  - 2011
SN  - 0125-1562
VL  - 42
IS  - 6
SP  - 1515
EP  - 1520
PB  - SEAMEO
CY  - Bangkok
ER  -