TY  - JOUR
A1  - Aarseth, Espen
T1  - Define real, Moron!
BT  - Some remarks on game ontologies
JF  - DIGAREC Series
N2  - Academic language should not be a ghetto dialect at odds with ordinary language, but rather an extension that is compatible with lay-language. To define ‘game’ with the unrealistic ambition of satisfying both lay-people and experts should not be a major concern for a game ontology, since the field it addresses is subject to cultural evolution and diachronic change. Instead of the impossible mission of turning the common word into an analytic concept, a useful task for an ontology of games is to model game differences, to show how the things we call games can be different from each other in a number of different ways.
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-49810
SN  - 1867-6219
SN  - 1867-6227
IS  - 6
SP  - 50
EP  - 69
ER  - 
TY  - JOUR
A1  - Abdo, A. A.
A1  - Ackermann, Margit
A1  - Ajello, M.
A1  - Allafort, A. J.
A1  - Baldini, L.
A1  - Ballet, J.
A1  - Barbiellini, G.
A1  - Baring, M. G.
A1  - Bastieri, D.
A1  - Bechtol, K. C.
A1  - Bellazzini, R.
A1  - Berenji, B.
A1  - Blandford, R. D.
A1  - Bloom, E. D.
A1  - Bonamente, E.
A1  - Borgland, A. W.
A1  - Bouvier, A.
A1  - Brandt, T. J.
A1  - Bregeon, Johan
A1  - Brez, A.
A1  - Brigida, M.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Buson, S.
A1  - Caliandro, G. A.
A1  - Cameron, R. A.
A1  - Cannon, A.
A1  - Caraveo, P. A.
A1  - Carrigan, Svenja
A1  - Casandjian, J. M.
A1  - Cavazzuti, E.
A1  - Cecchi, C.
A1  - Celik, O.
A1  - Charles, E.
A1  - Chekhtman, A.
A1  - Cheung, C. C.
A1  - Chiang, J.
A1  - Ciprini, S.
A1  - Claus, R.
A1  - Cohen-Tanugi, J.
A1  - Conrad, Jan
A1  - Cutini, S.
A1  - Dermer, C. D.
A1  - de Palma, F.
A1  - do Couto e Silva, E.
A1  - Drell, P. S.
A1  - Dubois, R.
A1  - Dumora, D.
A1  - Favuzzi, C.
A1  - Fegan, S. J.
A1  - Ferrara, E. C.
A1  - Focke, W. B.
A1  - Fortin, P.
A1  - Frailis, M.
A1  - Fuhrmann, L.
A1  - Fukazawa, Y.
A1  - Funk, S.
A1  - Fusco, P.
A1  - Gargano, F.
A1  - Gasparrini, D.
A1  - Gehrels, N.
A1  - Germani, S.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giroletti, M.
A1  - Glanzman, T.
A1  - Godfrey, G.
A1  - Grenier, I. A.
A1  - Guillemot, L.
A1  - Guiriec, S.
A1  - Hayashida, M.
A1  - Hays, E.
A1  - Horan, D.
A1  - Hughes, R. E.
A1  - Johannesson, G.
A1  - Johnson, A. S.
A1  - Johnson, W. N.
A1  - Kadler, M.
A1  - Kamae, T.
A1  - Katagiri, H.
A1  - Kataoka, J.
A1  - Knoedlseder, J.
A1  - Kuss, M.
A1  - Lande, J.
A1  - Latronico, L.
A1  - Lee, S. -H.
A1  - Lemoine-Goumard, M.
A1  - Longo, F.
A1  - Loparco, F.
A1  - Lott, B.
A1  - Lovellette, M. N.
A1  - Lubrano, P.
A1  - Madejski, G. M.
A1  - Makeev, A.
A1  - Max-Moerbeck, W.
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Mehault, J.
A1  - Michelson, P. F.
A1  - Mitthumsiri, W.
A1  - Mizuno, T.
A1  - Moiseev, A. A.
A1  - Monte, C.
A1  - Monzani, M. E.
A1  - Morselli, A.
A1  - Moskalenko, I. V.
A1  - Murgia, S.
A1  - Naumann-Godo, M.
A1  - Nishino, S.
A1  - Nolan, P. L.
A1  - Norris, J. P.
A1  - Nuss, E.
A1  - Ohsugi, T.
A1  - Okumura, A.
A1  - Omodei, N.
A1  - Orlando, E.
A1  - Ormes, J. F.
A1  - Paneque, D.
A1  - Panetta, J. H.
A1  - Parent, D.
A1  - Pavlidou, V.
A1  - Pearson, T. J.
A1  - Pelassa, V.
A1  - Pepe, M.
A1  - Pesce-Rollins, M.
A1  - Piron, F.
A1  - Porter, T. A.
A1  - Raino, S.
A1  - Rando, R.
A1  - Razzano, M.
A1  - Readhead, A.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Richards, J. L.
A1  - Ripken, J.
A1  - Ritz, S.
A1  - Roth, M.
A1  - Sadrozinski, H. F. -W.
A1  - Sanchez, D.
A1  - Sander, A.
A1  - Scargle, J. D.
A1  - Sgro, C.
A1  - Siskind, E. J.
A1  - Smith, P. D.
A1  - Spandre, G.
A1  - Spinelli, P.
A1  - Stawarz, L.
A1  - Stevenson, M.
A1  - Strickman, M. S.
A1  - Sokolovsky, K. V.
A1  - Suson, D. J.
A1  - Takahashi, H.
A1  - Takahashi, T.
A1  - Tanaka, T.
A1  - Thayer, J. B.
A1  - Thayer, J. G.
A1  - Thompson, D. J.
A1  - Tibaldo, L.
A1  - Torres, F.
A1  - Tosti, G.
A1  - Tramacere, A.
A1  - Uchiyama, Y.
A1  - Usher, T. L.
A1  - Vandenbroucke, J.
A1  - Vasileiou, V.
A1  - Vilchez, N.
A1  - Vitale, V.
A1  - Waite, A. P.
A1  - Wang, P.
A1  - Wehrle, A. E.
A1  - Winer, B. L.
A1  - Wood, K. S.
A1  - Yang, Z.
A1  - Ylinen, T.
A1  - Zensus, J. A.
A1  - Ziegler, M.
A1  - Aleksic, J.
A1  - Antonelli, L. A.
A1  - Antoranz, P.
A1  - Backes, Michael
A1  - Barrio, J. A.
A1  - Gonzalez, J. Becerra
A1  - Bednarek, W.
A1  - Berdyugin, A.
A1  - Berger, K.
A1  - Bernardini, E.
A1  - Biland, A.
A1  - Blanch Bigas, O.
A1  - Bock, R. K.
A1  - Boller, A.
A1  - Bonnoli, G.
A1  - Bordas, Pol
A1  - Tridon, D. Borla
A1  - Bosch-Ramon, Valentin
A1  - Bose, D.
A1  - Braun, I.
A1  - Bretz, T.
A1  - Camara, M.
A1  - Carmona, E.
A1  - Carosi, A.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Dazzi, F.
A1  - de Angelis, A.
A1  - del Pozo, E. De Cea
A1  - De Lotto, B.
A1  - De Maria, M.
A1  - De Sabata, F.
A1  - Mendez, C. Delgado
A1  - Ortega, A. Diago
A1  - Doert, M.
A1  - Dominguez, A.
A1  - Prester, Dijana Dominis
A1  - Dorner, D.
A1  - Doro, M.
A1  - Elsaesser, D.
A1  - Ferenc, D.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Lopen, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Gaug, M.
A1  - Giavitto, G.
A1  - Godinovi, N.
A1  - Hadasch, D.
A1  - Herrero, A.
A1  - Hildebrand, D.
A1  - Hoehne-Moench, D.
A1  - Hose, J.
A1  - Hrupec, D.
A1  - Jogler, T.
A1  - Klepser, S.
A1  - Kraehenbuehl, T.
A1  - Kranich, D.
A1  - Krause, J.
A1  - La Barbera, A.
A1  - Leonardo, E.
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Lopez, M.
A1  - Lorenz, E.
A1  - Majumdar, P.
A1  - Makariev, E.
A1  - Maneva, G.
A1  - Mankuzhiyil, N.
A1  - Mannheim, K.
A1  - Maraschi, L.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Mazin, D.
A1  - Meucci, M.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Miyamoto, H.
A1  - Moldon, J.
A1  - Moralejo, A.
A1  - Nieto, D.
A1  - Nilsson, K.
A1  - Orito, R.
A1  - Oya, I.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Partini, S.
A1  - Pasanen, M.
A1  - Pauss, F.
A1  - Pegna, R. G.
A1  - Perez-Torres, M. A.
A1  - Persic, M.
A1  - Peruzzo, J.
A1  - Pochon, J.
A1  - Moroni, P. G. Prada
A1  - Prada, F.
A1  - Prandini, E.
A1  - Puchades, N.
A1  - Puljak, I.
A1  - Reichardt, T.
A1  - Reinthal, R.
A1  - Rhode, W.
A1  - Ribo, M.
A1  - Rico, J.
A1  - Rissi, M.
A1  - Ruegamer, S.
A1  - Saggion, A.
A1  - Saito, K.
A1  - Saito, T. Y.
A1  - Salvati, M.
A1  - Sanchez-Conde, M.
A1  - Satalecka, K.
A1  - Scalzotto, V.
A1  - Scapin, V.
A1  - Schultz, C.
A1  - Schweizer, T.
A1  - Shayduk, M.
A1  - Shore, S. N.
A1  - Sierpowska-Bartosik, A.
A1  - Sillanpaa, A.
A1  - Sitarek, J.
A1  - Sobczynska, D.
A1  - Spanier, F.
A1  - Spiro, S.
A1  - Stamerra, A.
A1  - Steinke, B.
A1  - Storz, J.
A1  - Strah, N.
A1  - Struebig, J. C.
A1  - Suric, T.
A1  - Takalo, L. O.
A1  - Tavecchio, F.
A1  - Temnikov, P.
A1  - Terzic, T.
A1  - Tescaro, D.
A1  - Teshima, M.
A1  - Vankov, H.
A1  - Wagner, R. M.
A1  - Weitzel, Q.
A1  - Zabalza, V.
A1  - Zandanel, F.
A1  - Zanin, R.
A1  - Acciari, V. A.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Benbow, W.
A1  - Boltuch, D.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Huang, D.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Konopelko, A.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - McCutcheon, M.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R.
A1  - Otte, N.
A1  - Pandel, D.
A1  - Perkins, J. S.
A1  - Pichel, A.
A1  - Pohl, M.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Rovero, A. C.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Senturk, G. D.
A1  - Steele, D.
A1  - Swordy, S. P.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Varlotta, A.
A1  - Vincent, S.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Wood, M.
A1  - Zitzer, B.
A1  - Villata, M.
A1  - Raiteri, C. M.
A1  - Aller, H. D.
A1  - Aller, M. F.
A1  - Arkharov, A. A.
A1  - Blinov, D. A.
A1  - Calcidese, P.
A1  - Chen, W. P.
A1  - Efimova, N. V.
A1  - Kimeridze, G.
A1  - Konstantinova, T. S.
A1  - Kopatskaya, E. N.
A1  - Koptelova, E.
A1  - Kurtanidze, O. M.
A1  - Kurtanidze, S. O.
A1  - Lahteenmaki, A.
A1  - Larionov, V. M.
A1  - Larionova, E. G.
A1  - Larionova, L. V.
A1  - Ligustri, R.
A1  - Morozova, D. A.
A1  - Nikolashvili, M. G.
A1  - Sigua, L. A.
A1  - Troitsky, I. S.
A1  - Angelakis, E.
A1  - Capalbi, M.
A1  - Carraminana, A.
A1  - Carrasco, L.
A1  - Cassaro, P.
A1  - de la Fuente, E.
A1  - Gurwell, M. A.
A1  - Kovalev, Y. Y.
A1  - Kovalev, Yu. A.
A1  - Krichbaum, T. P.
A1  - Krimm, H. A.
A1  - Leto, Paolo
A1  - Lister, M. L.
A1  - Maccaferri, G.
A1  - Moody, J. W.
A1  - Mori, Y.
A1  - Nestoras, I.
A1  - Orlati, A.
A1  - Pagani, C.
A1  - Pace, C.
A1  - Pearson, R.
A1  - Perri, M.
A1  - Piner, B. G.
A1  - Pushkarev, A. B.
A1  - Ros, E.
A1  - Sadun, A. C.
A1  - Sakamoto, T.
A1  - Tornikoski, M.
A1  - Yatsu, Y.
A1  - Zook, A.
T1  - Insights into the high-energy gamma-Ray emission of markarian 501 fromextensive multifrequency observations in the fermi era
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.
KW  - acceleration of particles
KW  - BL Lacertae objects: general
KW  - BL Lacertae objects: individual (Mrk 501)
KW  - galaxies: active
KW  - gamma rays: general
KW  - radiation mechanisms: non-thermal
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/727/2/129
SN  - 0004-637X
VL  - 727
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abdo, A. A.
A1  - Ackermann, Margit
A1  - Ajello, M.
A1  - Allafort, A. J.
A1  - Baldini, L.
A1  - Ballet, J.
A1  - Barbiellini, G.
A1  - Baring, M. G.
A1  - Bastieri, D.
A1  - Bellazzini, R.
A1  - Berenji, B.
A1  - Blandford, R. D.
A1  - Bloom, E. D.
A1  - Bonamente, E.
A1  - Borgland, A. W.
A1  - Bouvier, A.
A1  - Brandt, T. J.
A1  - Bregeon, Johan
A1  - Brigida, M.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Buson, S.
A1  - Caliandro, G. A.
A1  - Cameron, R. A.
A1  - Caraveo, P. A.
A1  - Casandjian, J. M.
A1  - Cecchi, C.
A1  - Chaty, S.
A1  - Chekhtman, A.
A1  - Cheung, C. C.
A1  - Chiang, J.
A1  - Cillis, A. N.
A1  - Ciprini, S.
A1  - Claus, R.
A1  - Cohen-Tanugi, J.
A1  - Conrad, Jan
A1  - Corbel, S.
A1  - Cutini, S.
A1  - de Angelis, A.
A1  - de Palma, F.
A1  - Dermer, C. D.
A1  - Digel, S. W.
A1  - do Couto e Silva, E.
A1  - Drell, P. S.
A1  - Drlica-Wagner, A.
A1  - Dubois, R.
A1  - Dumora, D.
A1  - Favuzzi, C.
A1  - Ferrara, E. C.
A1  - Fortin, P.
A1  - Frailis, M.
A1  - Fukazawa, Y.
A1  - Fukui, Y.
A1  - Funk, S.
A1  - Fusco, P.
A1  - Gargano, F.
A1  - Gasparrini, D.
A1  - Gehrels, N.
A1  - Germani, S.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giroletti, M.
A1  - Glanzman, T.
A1  - Godfrey, G.
A1  - Grenier, I. A.
A1  - Grondin, M. -H.
A1  - Guiriec, S.
A1  - Hadasch, D.
A1  - Hanabata, Y.
A1  - Harding, A. K.
A1  - Hayashida, M.
A1  - Hayashi, K.
A1  - Hays, E.
A1  - Horan, D.
A1  - Jackson, M. S.
A1  - Johannesson, G.
A1  - Johnson, A. S.
A1  - Kamae, T.
A1  - Katagiri, H.
A1  - Kataoka, J.
A1  - Kerr, M.
A1  - Knoedlseder, J.
A1  - Kuss, M.
A1  - Lande, J.
A1  - Latronico, L.
A1  - Lee, S. -H.
A1  - Lemoine-Goumard, M.
A1  - Longo, F.
A1  - Loparco, F.
A1  - Lovellette, M. N.
A1  - Lubrano, P.
A1  - Madejski, G. M.
A1  - Makeev, A.
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Michelson, P. F.
A1  - Mignani, R. P.
A1  - Mitthumsiri, W.
A1  - Mizuno, T.
A1  - Moiseev, A. A.
A1  - Monte, C.
A1  - Monzani, M. E.
A1  - Morselli, A.
A1  - Moskalenko, I. V.
A1  - Murgia, S.
A1  - Naumann-Godo, M.
A1  - Nolan, P. L.
A1  - Norris, J. P.
A1  - Nuss, E.
A1  - Ohsugi, T.
A1  - Okumura, A.
A1  - Orlando, E.
A1  - Ormes, J. F.
A1  - Paneque, D.
A1  - Parent, D.
A1  - Pelassa, V.
A1  - Pesce-Rollins, M.
A1  - Pierbattista, M.
A1  - Piron, F.
A1  - Pohl, Martin
A1  - Porter, T. A.
A1  - Raino, S.
A1  - Rando, R.
A1  - Razzano, M.
A1  - Reimer, O.
A1  - Reposeur, T.
A1  - Ritz, S.
A1  - Romani, R. W.
A1  - Roth, M.
A1  - Sadrozinski, H. F. -W.
A1  - Parkinson, P. M. Saz
A1  - Sgro, C.
A1  - Smith, D. A.
A1  - Smith, P. D.
A1  - Spandre, G.
A1  - Spinelli, P.
A1  - Strickman, M. S.
A1  - Tajima, H.
A1  - Takahashi, H.
A1  - Takahashi, T.
A1  - Tanaka, T.
A1  - Thayer, J. G.
A1  - Thayer, J. B.
A1  - Thompson, D. J.
A1  - Tibaldo, L.
A1  - Tibolla, O.
A1  - Torres, D. F.
A1  - Tosti, G.
A1  - Tramacere, A.
A1  - Troja, E.
A1  - Uchiyama, Y.
A1  - Vandenbroucke, J.
A1  - Vasileiou, V.
A1  - Vianello, G.
A1  - Vilchez, N.
A1  - Vitale, V.
A1  - Waite, A. P.
A1  - Wang, P.
A1  - Winer, B. L.
A1  - Wood, K. S.
A1  - Yamamoto, H.
A1  - Yamazaki, R.
A1  - Yang, Z.
A1  - Ziegler, M.
T1  - Observations of the young supernova remnant RX J1713.7-3946 with the fermi large area telescope
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0 degrees.55 +/- 0 degrees.04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Gamma = 1.5 +/- 0.1 that coincides in normalization with the steeper H. E. S. S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.
KW  - acceleration of particles
KW  - gamma rays: general
KW  - gamma rays: ISM
KW  - ISM: individual objects (RX J1713.7-3946)
KW  - ISM: supernova remnants
KW  - radiation mechanisms: non-thermal
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/734/1/28
SN  - 0004-637X
VL  - 734
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Abdolvahab, Rouhollah Haji
A1  - Metzler, Ralf
A1  - Ejtehadi, Mohammad Reza
T1  - First passage time distribution of chaperone driven polymer translocation through a nanopore homopolymer and heteropolymer cases
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - Combining the advection-diffusion equation approach with Monte Carlo simulations we study chaperone driven polymer translocation of a stiff polymer through a nanopore. We demonstrate that the probability density function of first passage times across the pore depends solely on the Peclet number, a dimensionless parameter comparing drift strength and diffusivity. Moreover it is shown that the characteristic exponent in the power-law dependence of the translocation time on the chain length, a function of the chaperone-polymer binding energy, the chaperone concentration, and the chain length, is also effectively determined by the Peclet number. We investigate the effect of the chaperone size on the translocation process. In particular, for large chaperone size, the translocation progress and the mean waiting time as function of the reaction coordinate exhibit pronounced sawtooth-shapes. The effects of a heterogeneous polymer sequence on the translocation dynamics is studied in terms of the translocation velocity, the probability distribution for the translocation progress, and the monomer waiting times. (C) 2011 American Institute of Physics.
Y1  - 2011
U6  - https://doi.org/10.1063/1.3669427
SN  - 0021-9606
VL  - 135
IS  - 24
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - BOOK
A1  - Abedjan, Ziawasch
A1  - Naumann, Felix
T1  - Advancing the discovery of unique column combinations
N2  - Unique column combinations of a relational database table are sets of columns that contain only unique values. Discovering such combinations is a fundamental research problem and has many different data management and knowledge discovery applications. Existing discovery algorithms are either brute force or have a high memory load and can thus be applied only to small datasets or samples. In this paper, the wellknown GORDIAN algorithm and "Apriori-based" algorithms are compared and analyzed for further optimization. We greatly improve the Apriori algorithms through efficient candidate generation and statistics-based pruning methods. A hybrid solution HCAGORDIAN combines the advantages of GORDIAN and our new algorithm HCA, and it significantly outperforms all previous work in many situations.
N2  - Unique-Spaltenkombinationen sind Spaltenkombinationen einer Datenbanktabelle, die nur einzigartige Werte beinhalten. Das Finden von Unique-Spaltenkombinationen spielt sowohl eine wichtige Rolle im Bereich der Grundlagenforschung von Informationssystemen als auch in Anwendungsgebieten wie dem Datenmanagement und der Erkenntnisgewinnung aus Datenbeständen. Vorhandene Algorithmen, die dieses Problem angehen, sind entweder Brute-Force oder benötigen zu viel Hauptspeicher. Deshalb können diese Algorithmen nur auf kleine Datenmengen angewendet werden. In dieser Arbeit werden der bekannte GORDIAN-Algorithmus und Apriori-basierte Algorithmen zum Zwecke weiterer Optimierung analysiert. Wir verbessern die Apriori Algorithmen durch eine effiziente Kandidatengenerierung und Heuristikbasierten Kandidatenfilter. Eine Hybride Lösung, HCA-GORDIAN, kombiniert die Vorteile von GORDIAN und unserem neuen Algorithmus HCA, welche die bisherigen Algorithmen hinsichtlich der Effizienz in vielen Situationen übertrifft.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 51 
KW  - Apriori
KW  - eindeutig
KW  - funktionale Abhängigkeit
KW  - Schlüsselentdeckung
KW  - Data Profiling
KW  - apriori
KW  - unique
KW  - functional dependency
KW  - key discovery
KW  - data profiling
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-53564
SN  - 978-3-86956-148-6
SN  - 1613-5652
SN  - 2191-1665
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Abel, M. W.
A1  - Shepelyansky, Dima L.
T1  - Google matrix of business process management
JF  - The European physical journal : B, Condensed matter and complex systems
N2  - Development of efficient business process models and determination of their characteristic properties are subject of intense interdisciplinary research. Here, we consider a business process model as a directed graph. Its nodes correspond to the units identified by the modeler and the link direction indicates the causal dependencies between units. It is of primary interest to obtain the stationary flow on such a directed graph, which corresponds to the steady-state of a firm during the business process. Following the ideas developed recently for the World Wide Web, we construct the Google matrix for our business process model and analyze its spectral properties. The importance of nodes is characterized by PageRank and recently proposed CheiRank and 2DRank, respectively. The results show that this two-dimensional ranking gives a significant information about the influence and communication properties of business model units. We argue that the Google matrix method, described here, provides a new efficient tool helping companies to make their decisions on how to evolve in the exceedingly dynamic global market.
Y1  - 2011
U6  - https://doi.org/10.1140/epjb/e2010-10710-y
SN  - 1434-6028
VL  - 84
IS  - 4
SP  - 493
EP  - 500
PB  - Springer
CY  - New York
ER  - 
TY  - THES
A1  - AbuJarour, Mohammed
T1  - Enriched service descriptions: sources, approaches and usages
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Acciari, V. A.
A1  - Aliu, E.
A1  - Araya, M.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Duke, C.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Imran, A.
A1  - Kaaret, P.
A1  - Kertzman, M.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Madhavan, A. S.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - McArthur, S.
A1  - Moriarty, P.
A1  - Ong, R. A.
A1  - Otte, A. N.
A1  - Pandel, D.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Saxon, D. B.
A1  - Sembroski, G. H.
A1  - Sentuerk, G. D.
A1  - Smith, A. W.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Varlotta, A.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Weng, S.
A1  - Williams, D. A.
A1  - Wood, M.
A1  - Zitzer, B.
T1  - Gamma-ray observations of the Be/Pulsar binary 1A 0535+262 during a Giant X-Ray outburst
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - Giant X-ray outbursts, with luminosities of about 10(37) erg s(-1), are observed roughly every five years from the nearby Be/pulsar binary 1A 0535+262. In this article, we present observations of the source with VERITAS at very high energies (VHEs; E > 100 GeV) triggered by the X-ray outburst in 2009 December. The observations started shortly after the onset of the outburst and provided comprehensive coverage of the episode, as well as the 111 day binary orbit. No VHE emission is evident at any time. We also examined data from the contemporaneous observations of 1A 0535+262 with the Fermi/Large Area Telescope at high-energy photons (E > 0.1 GeV) and failed to detect the source at GeV energies. The X-ray continua measured with the Swift/X-Ray Telescope and the RXTE/PCA can be well described by the combination of blackbody and Comptonized emission from thermal electrons. Therefore, the gamma-ray and X-ray observations suggest the absence of a significant population of non-thermal particles in the system. This distinguishes 1A 0535+262 from those Be X-ray binaries (such as PSR B1259-63 and LS I +61 degrees 303) that have been detected at GeV-TeV energies. We discuss the implications of the results on theoretical models.
KW  - acceleration of particles
KW  - binaries: general
KW  - gamma rays: general
KW  - stars: individual (1A 0535+262)
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/733/2/96
SN  - 0004-637X
VL  - 733
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Acciari, V. A.
A1  - Aliu, E.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Christiansen, J. L.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Duke, C.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Jackson, D. J.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Madhavan, A. S.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Newbold, M. D.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Ruppel, J.
A1  - Saxon, D. B.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Sentuerk, G. D.
A1  - Smith, A. W.
A1  - Staszak, D.
A1  - Swordy, S. P.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Varlotta, A.
A1  - Vassiliev, V. V.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Wood, M.
T1  - Veritas observations of gamma-ray bursts detected by swift
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present the results of 16 Swift-triggered Gamma-ray burst (GRB) follow-up observations taken with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) telescope array from 2007 January to 2009 June. The median energy threshold and response time of these observations were 260 GeV and 320 s, respectively. Observations had an average duration of 90 minutes. Each burst is analyzed independently in two modes: over the whole duration of the observations and again over a shorter timescale determined by the maximum VERITAS sensitivity to a burst with a t(-1.5) time profile. This temporal model is characteristic of GRB afterglows with high-energy, long-lived emission that have been detected by the Large Area Telescope on board the Fermi satellite. No significant very high energy (VHE) gamma-ray emission was detected and upper limits above the VERITAS threshold energy are calculated. The VERITAS upper limits are corrected for gamma-ray extinction by the extragalactic background light and interpreted in the context of the keV emission detected by Swift. For some bursts the VHE emission must have less power than the keV emission, placing constraints on inverse Compton models of VHE emission.
KW  - astroparticle physics
KW  - gamma-ray burst: general
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/743/1/62
SN  - 0004-637X
VL  - 743
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Acciari, V. A.
A1  - Aliu, E.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Duke, C.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - LeBohec, S.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Ruppel, J.
A1  - Saxon, D. B.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Senturk, G. D.
A1  - Smith, A. W.
A1  - Staszak, D.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Varlotta, A.
A1  - Vassiliev, V. V.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Zitzer, B.
T1  - VERITAS OBSERVATIONS OF THE TeV BINARY LS I+61 degrees 303 DURING 2008-2010
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We present the results of observations of the TeV binary LS I + 61 degrees 303 with the VERITAS telescope array between 2008 and 2010, at energies above 300 GeV. In the past, both ground-based gamma-ray telescopes VERITAS and MAGIC have reported detections of TeV emission near the apastron phases of the binary orbit. The observations presented here show no strong evidence for TeV emission during these orbital phases; however, during observations taken in late 2010, significant emission was detected from the source close to the phase of superior conjunction (much closer to periastron passage) at a 5.6 standard deviation (5.6 sigma) post-trials significance. In total, between 2008 October and 2010 December a total exposure of 64.5 hr was accumulated with VERITAS on LS I + 61 degrees 303, resulting in an excess at the 3.3 sigma significance level for constant emission over the entire integrated data set. The flux upper limits derived for emission during the previously reliably active TeV phases (i.e., close to apastron) are less than 5% of the Crab Nebula flux in the same energy range. This result stands in apparent contrast to previous observations by both MAGIC and VERITAS which detected the source during these phases at 10% of the Crab Nebula flux. During the two year span of observations, a large amount of X-ray data were also accrued on LS I + 61 degrees 303 by the Swift X-ray Telescope and the Rossi X-ray Timing Explorer Proportional Counter Array. We find no evidence for a correlation between emission in the X-ray and TeV regimes during 20 directly overlapping observations. We also comment on data obtained contemporaneously by the Fermi Large Area Telescope.
KW  - binaries: general
KW  - gamma rays: general
KW  - X-rays: binaries
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/738/1/3
SN  - 0004-637X
VL  - 738
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Acciari, V. A.
A1  - Aliu, E.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Duke, C.
A1  - Errando, M.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Hughes, J. P.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - LeBohec, S.
A1  - Madhavan, A. S.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Pandel, D.
A1  - Park, N. H.
A1  - Perkins, J. S.
A1  - Pohl, Martin
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Saxon, D. B.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Senturk, G. Demet
A1  - Slane, P.
A1  - Smith, A. W.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Varlotta, A.
A1  - Vassiliev, V. V.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Wood, M.
A1  - Zitzer, B.
T1  - Discovery of OF TeV Gamma-Ray emission from tycho's supernova remnant
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters
N2  - We report the discovery of TeV gamma-ray emission from the Type Ia supernova remnant (SNR) G120.1+1.4, known as Tycho's SNR. Observations performed in the period 2008-2010 with the VERITAS ground-based gamma-ray observatory reveal weak emission coming from the direction of the remnant, compatible with a point source located at 00(h)25(m)27(s).0, +64 degrees 10'50 '' (J2000). The TeV photon spectrum measured by VERITAS can be described with a power law dN/dE = C(E/3.42 TeV)(-Gamma) with Gamma = 1.95 +/- 0.51(stat) +/- 0.30(sys) and C = (1.55 +/- 0.43(stat) +/- 0.47(sys)) x 10(-14) cm(-2) s(-1) TeV-1. The integral flux above 1 TeV corresponds to similar to 0.9% of the steady Crab Nebula emission above the same energy, making it one of the weakest sources yet detected in TeV gamma rays. We present both leptonic and hadronic models that can describe the data. The lowest magnetic field allowed in these models is similar to 80 mu G, which may be interpreted as evidence for magnetic field amplification.
KW  - gamma rays: general
KW  - ISM: individual objects (G120.1+01.4, Tycho=VER J0025+641)
Y1  - 2011
U6  - https://doi.org/10.1088/2041-8205/730/2/L20
SN  - 2041-8205
VL  - 730
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Ackermann, Margit
A1  - Ajello, M.
A1  - Allafort, A. J.
A1  - Baldini, L.
A1  - Ballet, J.
A1  - Barbiellini, G.
A1  - Bastieri, D.
A1  - Belfiore, A.
A1  - Bellazzini, R.
A1  - Berenji, B.
A1  - Blandford, R. D.
A1  - Bloom, E. D.
A1  - Bonamente, E.
A1  - Borgland, A. W.
A1  - Bottacini, E.
A1  - Brigida, M.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Buson, S.
A1  - Caliandro, G. A.
A1  - Cameron, R. A.
A1  - Caraveo, P. A.
A1  - Casandjian, J. M.
A1  - Cecchi, C.
A1  - Chekhtman, A.
A1  - Cheung, C. C.
A1  - Chiang, J.
A1  - Ciprini, S.
A1  - Claus, R.
A1  - Cohen-Tanugi, J.
A1  - de Angelis, A.
A1  - de Palma, F.
A1  - Dermer, C. D.
A1  - do Couto e Silva, E.
A1  - Drell, P. S.
A1  - Dumora, D.
A1  - Favuzzi, C.
A1  - Fegan, S. J.
A1  - Focke, W. B.
A1  - Fortin, P.
A1  - Fukazawa, Y.
A1  - Fusco, P.
A1  - Gargano, F.
A1  - Germani, S.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giroletti, M.
A1  - Glanzman, T.
A1  - Godfrey, G.
A1  - Grenier, I. A.
A1  - Guillemot, L.
A1  - Guiriec, S.
A1  - Hadasch, D.
A1  - Hanabata, Y.
A1  - Harding, A. K.
A1  - Hayashida, M.
A1  - Hayashi, K.
A1  - Hays, E.
A1  - Johannesson, G.
A1  - Johnson, A. S.
A1  - Kamae, T.
A1  - Katagiri, H.
A1  - Kataoka, J.
A1  - Kerr, M.
A1  - Knoedlseder, J.
A1  - Kuss, M.
A1  - Lande, J.
A1  - Latronico, L.
A1  - Lee, S. -H.
A1  - Longo, F.
A1  - Loparco, F.
A1  - Lott, B.
A1  - Lovellette, M. N.
A1  - Lubrano, P.
A1  - Martin, P.
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Mehault, J.
A1  - Michelson, P. F.
A1  - Mitthumsiri, W.
A1  - Mizuno, T.
A1  - Monte, C.
A1  - Monzani, M. E.
A1  - Morselli, A.
A1  - Moskalenko, I. V.
A1  - Murgia, S.
A1  - Naumann-Godo, M.
A1  - Nolan, P. L.
A1  - Norris, J. P.
A1  - Nuss, E.
A1  - Ohsugi, T.
A1  - Okumura, A.
A1  - Orlando, E.
A1  - Ormes, J. F.
A1  - Ozaki, M.
A1  - Paneque, D.
A1  - Parent, D.
A1  - Pesce-Rollins, M.
A1  - Pierbattista, M.
A1  - Piron, F.
A1  - Pohl, Martin
A1  - Prokhorov, D.
A1  - Raino, S.
A1  - Rando, R.
A1  - Razzano, M.
A1  - Reposeur, T.
A1  - Ritz, S.
A1  - Parkinson, P. M. Saz
A1  - Sgro, C.
A1  - Siskind, E. J.
A1  - Smith, P. D.
A1  - Spinelli, P.
A1  - Strong, A. W.
A1  - Takahashi, H.
A1  - Tanaka, T.
A1  - Thayer, J. G.
A1  - Thayer, J. B.
A1  - Thompson, D. J.
A1  - Tibaldo, L.
A1  - Torres, D. F.
A1  - Tosti, G.
A1  - Tramacere, A.
A1  - Troja, E.
A1  - Uchiyama, Y.
A1  - Vandenbroucke, J.
A1  - Vasileiou, V.
A1  - Vianello, G.
A1  - Vitale, V.
A1  - Waite, A. P.
A1  - Wang, P.
A1  - Winer, B. L.
A1  - Wood, K. S.
A1  - Yang, Z.
A1  - Zimmer, S.
A1  - Bontemps, S.
T1  - A cocoon of freshly accelerated cosmic rays detected by fermi in the cygnus superbubble
JF  - Science
N2  - The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.
Y1  - 2011
U6  - https://doi.org/10.1126/science.1210311
SN  - 0036-8075
VL  - 334
IS  - 6059
SP  - 1103
EP  - 1107
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Actis, M.
A1  - Agnetta, G.
A1  - Aharonian, Felix A.
A1  - Akhperjanian, A. G.
A1  - Aleksic, J.
A1  - Aliu, E.
A1  - Allan, D.
A1  - Allekotte, I.
A1  - Antico, F.
A1  - Antonelli, L. A.
A1  - Antoranz, P.
A1  - Aravantinos, A.
A1  - Arlen, T.
A1  - Arnaldi, H.
A1  - Artmann, S.
A1  - Asano, K.
A1  - Asorey, H. G.
A1  - Baehr, J.
A1  - Bais, A.
A1  - Baixeras, C.
A1  - Bajtlik, S.
A1  - Balis, D.
A1  - Bamba, A.
A1  - Barbier, C.
A1  - Barcelo, M.
A1  - Barnacka, Anna
A1  - Barnstedt, Jürgen
A1  - de Almeida, U. Barres
A1  - Barrio, J. A.
A1  - Basso, S.
A1  - Bastieri, D.
A1  - Bauer, C.
A1  - Becerra Gonzalez, J.
A1  - Becherini, Yvonne
A1  - Bechtol, K. C.
A1  - Becker, J.
A1  - Beckmann, Volker
A1  - Bednarek, W.
A1  - Behera, B.
A1  - Beilicke, M.
A1  - Belluso, M.
A1  - Benallou, M.
A1  - Benbow, W.
A1  - Berdugo, J.
A1  - Berger, K.
A1  - Bernardino, T.
A1  - Bernlöhr, K.
A1  - Biland, A.
A1  - Billotta, S.
A1  - Bird, T.
A1  - Birsin, E.
A1  - Bissaldi, E.
A1  - Blake, S.
A1  - Blanch Bigas, O.
A1  - Bobkov, A. A.
A1  - Bogacz, L.
A1  - Bogdan, M.
A1  - Boisson, Catherine
A1  - Boix Gargallo, J.
A1  - Bolmont, J.
A1  - Bonanno, G.
A1  - Bonardi, A.
A1  - Bonev, T.
A1  - Borkowski, Janett
A1  - Botner, O.
A1  - Bottani, A.
A1  - Bourgeat, M.
A1  - Boutonnet, C.
A1  - Bouvier, A.
A1  - Brau-Nogue, S.
A1  - Braun, I.
A1  - Bretz, T.
A1  - Briggs, M. S.
A1  - Brun, Pierre
A1  - Brunetti, L.
A1  - Buckley, H.
A1  - Bugaev, V.
A1  - Buehler, R.
A1  - Bulik, Tomasz
A1  - Busetto, G.
A1  - Buson, S.
A1  - Byrum, K.
A1  - Cailles, M.
A1  - Cameron, R. A.
A1  - Canestrari, R.
A1  - Cantu, S.
A1  - Carmona, E.
A1  - Carosi, A.
A1  - Carr, John
A1  - Carton, P. H.
A1  - Casiraghi, M.
A1  - Castarede, H.
A1  - Catalano, O.
A1  - Cavazzani, S.
A1  - Cazaux, S.
A1  - Cerruti, B.
A1  - Cerruti, M.
A1  - Chadwick, M.
A1  - Chiang, J.
A1  - Chikawa, M.
A1  - Cieslar, M.
A1  - Ciesielska, M.
A1  - Cillis, A. N.
A1  - Clerc, C.
A1  - Colin, P.
A1  - Colome, J.
A1  - Compin, M.
A1  - Conconi, P.
A1  - Connaughton, V.
A1  - Conrad, Jan
A1  - Contreras, J. L.
A1  - Coppi, P.
A1  - Corlier, M.
A1  - Corona, P.
A1  - Corpace, O.
A1  - Corti, D.
A1  - Cortina, J.
A1  - Costantini, H.
A1  - Cotter, G.
A1  - Courty, B.
A1  - Couturier, S.
A1  - Covino, S.
A1  - Croston, J.
A1  - Cusumano, G.
A1  - Daniel, M. K.
A1  - Dazzi, F.
A1  - Deangelis, A.
A1  - de Cea del Pozo, E.
A1  - Dal Pino, E. M. de Gouveia
A1  - de Jager, O.
A1  - de la Calle Perez, I.
A1  - De La Vega, G.
A1  - De Lotto, B.
A1  - de Naurois, M.
A1  - Wilhelmi, E. de Ona
A1  - de Souza, V.
A1  - Decerprit, B.
A1  - Deil, C.
A1  - Delagnes, E.
A1  - Deleglise, G.
A1  - Delgado, C.
A1  - Dettlaff, T.
A1  - Di Paolo, A.
A1  - Di Pierro, F.
A1  - Diaz, C.
A1  - Dick, J.
A1  - Dickinson, H.
A1  - Digel, S. W.
A1  - Dimitrov, D.
A1  - Disset, G.
A1  - Djannati-Ataï, A.
A1  - Doert, M.
A1  - Domainko, W.
A1  - Dorner, D.
A1  - Doro, M.
A1  - Dournaux, J. -L.
A1  - Dravins, D.
A1  - Drury, L.
A1  - Dubois, F.
A1  - Dubois, R.
A1  - Dubus, G.
A1  - Dufour, C.
A1  - Durand, D.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edy, E.
A1  - Egberts, Kathrin
A1  - Eleftheriadis, C.
A1  - Elles, S.
A1  - Emmanoulopoulos, D.
A1  - Enomoto, R.
A1  - Ernenwein, J. -P.
A1  - Errando, M.
A1  - Etchegoyen, A.
A1  - Falcone, A. D.
A1  - Farakos, K.
A1  - Farnier, C.
A1  - Federici, S.
A1  - Feinstein, F.
A1  - Ferenc, D.
A1  - Fillin-Martino, E.
A1  - Fink, D.
A1  - Finley, C.
A1  - Finley, J. P.
A1  - Firpo, R.
A1  - Florin, D.
A1  - Foehr, C.
A1  - Fokitis, E.
A1  - Font, Ll.
A1  - Fontaine, G.
A1  - Fontana, A.
A1  - Foerster, A.
A1  - Fortson, L.
A1  - Fouque, N.
A1  - Fransson, C.
A1  - Fraser, G. W.
A1  - Fresnillo, L.
A1  - Fruck, C.
A1  - Fujita, Y.
A1  - Fukazawa, Y.
A1  - Funk, S.
A1  - Gaebele, W.
A1  - Gabici, S.
A1  - Gadola, A.
A1  - Galante, N.
A1  - Gallant, Y.
A1  - Garcia, B.
A1  - Garcia Lopez, R. J.
A1  - Garrido, D.
A1  - Garrido, L.
A1  - Gascon, D.
A1  - Gasq, C.
A1  - Gaug, M.
A1  - Gaweda, J.
A1  - Geffroy, N.
A1  - Ghag, C.
A1  - Ghedina, A.
A1  - Ghigo, M.
A1  - Gianakaki, E.
A1  - Giarrusso, S.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Giro, E.
A1  - Giubilato, P.
A1  - Glanzman, T.
A1  - Glicenstein, J. -F.
A1  - Gochna, M.
A1  - Golev, V.
A1  - Gomez Berisso, M.
A1  - Gonzalez, A.
A1  - Gonzalez, F.
A1  - Granena, F.
A1  - Graciani, R.
A1  - Granot, J.
A1  - Gredig, R.
A1  - Green, A.
A1  - Greenshaw, T.
A1  - Grimm, O.
A1  - Grube, J.
A1  - Grudzinska, M.
A1  - Grygorczuk, J.
A1  - Guarino, V.
A1  - Guglielmi, L.
A1  - Guilloux, F.
A1  - Gunji, S.
A1  - Gyuk, G.
A1  - Hadasch, D.
A1  - Haefner, D.
A1  - Hagiwara, R.
A1  - Hahn, J.
A1  - Hallgren, A.
A1  - Hara, S.
A1  - Hardcastle, M. J.
A1  - Hassan, T.
A1  - Haubold, T.
A1  - Hauser, M.
A1  - Hayashida, M.
A1  - Heller, R.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Herrero, A.
A1  - Hinton, James Anthony
A1  - Hoffmann, D.
A1  - Hofmann, W.
A1  - Hofverberg, P.
A1  - Horns, D.
A1  - Hrupec, D.
A1  - Huan, H.
A1  - Huber, B.
A1  - Huet, J. -M.
A1  - Hughes, G.
A1  - Hultquist, K.
A1  - Humensky, T. B.
A1  - Huppert, J. -F.
A1  - Ibarra, A.
A1  - Illa, J. M.
A1  - Ingjald, J.
A1  - Inoue, S.
A1  - Inoue, Y.
A1  - Ioka, K.
A1  - Jablonski, C.
A1  - Jacholkowska, A.
A1  - Janiak, M.
A1  - Jean, P.
A1  - Jensen, H.
A1  - Jogler, T.
A1  - Jung, I.
A1  - Kaaret, P.
A1  - Kabuki, S.
A1  - Kakuwa, J.
A1  - Kalkuhl, C.
A1  - Kankanyan, R.
A1  - Kapala, M.
A1  - Karastergiou, A.
A1  - Karczewski, M.
A1  - Karkar, S.
A1  - Karlsson, N.
A1  - Kasperek, J.
A1  - Katagiri, H.
A1  - Katarzynski, K.
A1  - Kawanaka, N.
A1  - Kedziora, B.
A1  - Kendziorra, E.
A1  - Khelifi, B.
A1  - Kieda, D.
A1  - Kifune, T.
A1  - Kihm, T.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Knapp, J.
A1  - Knappy, A. R.
A1  - Kneiske, T.
A1  - Knoedlseder, J.
A1  - Koeck, F.
A1  - Kodani, K.
A1  - Kohri, K.
A1  - Kokkotas, K.
A1  - Komin, N.
A1  - Konopelko, A.
A1  - Kosack, K.
A1  - Kossakowski, R.
A1  - Kostka, P.
A1  - Kotula, J.
A1  - Kowal, G.
A1  - Koziol, J.
A1  - Kraehenbuehl, T.
A1  - Krause, J.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Kretzschmann, A.
A1  - Kubo, H.
A1  - Kudryavtsev, V. A.
A1  - Kushida, J.
A1  - La Barbera, N.
A1  - La Parola, V.
A1  - La Rosa, G.
A1  - Lopez, A.
A1  - Lamanna, G.
A1  - Laporte, P.
A1  - Lavalley, C.
A1  - Le Flour, T.
A1  - Le Padellec, A.
A1  - Lenain, J. -P.
A1  - Lessio, L.
A1  - Lieunard, B.
A1  - Lindfors, E.
A1  - Liolios, A.
A1  - Lohse, T.
A1  - Lombardi, S.
A1  - Lopatin, A.
A1  - Lorenz, E.
A1  - Lubinski, P.
A1  - Luz, O.
A1  - Lyard, E.
A1  - Maccarone, M. C.
A1  - Maccarone, T.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - Maltezos, S.
A1  - Malkiewicz, P.
A1  - Mana, C.
A1  - Manalaysay, A.
A1  - Maneva, G.
A1  - Mangano, A.
A1  - Manigot, P.
A1  - Marin, J.
A1  - Mariotti, M.
A1  - Markoff, S.
A1  - Martinez, G.
A1  - Martinez, M.
A1  - Mastichiadis, A.
A1  - Matsumoto, H.
A1  - Mattiazzo, S.
A1  - Mazin, D.
A1  - McComb, T. J. L.
A1  - McCubbin, N.
A1  - McHardy, I.
A1  - Medina, C.
A1  - Melkumyan, D.
A1  - Mendes, A.
A1  - Mertsch, P.
A1  - Meucci, M.
A1  - Michalowski, J.
A1  - Micolon, P.
A1  - Mineo, T.
A1  - Mirabal, N.
A1  - Mirabel, F.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Mizuno, T.
A1  - Moal, B.
A1  - Moderski, R.
A1  - Molinari, E.
A1  - Monteiro, I.
A1  - Moralejo, A.
A1  - Morello, C.
A1  - Mori, K.
A1  - Motta, G.
A1  - Mottez, F.
A1  - Moulin, Emmanuel
A1  - Mukherjee, R.
A1  - Munar, P.
A1  - Muraishi, H.
A1  - Murase, K.
A1  - Murphy, A. Stj.
A1  - Nagataki, S.
A1  - Naito, T.
A1  - Nakamori, T.
A1  - Nakayama, K.
A1  - Naumann, C. L.
A1  - Naumann, D.
A1  - Nayman, P.
A1  - Nedbal, D.
A1  - Niedzwiecki, A.
A1  - Niemiec, J.
A1  - Nikolaidis, A.
A1  - Nishijima, K.
A1  - Nolan, S. J.
A1  - Nowak, N.
A1  - O'Brien, P. T.
A1  - Ochoa, I.
A1  - Ohira, Y.
A1  - Ohishi, M.
A1  - Ohka, H.
A1  - Okumura, A.
A1  - Olivetto, C.
A1  - Ong, R. A.
A1  - Orito, R.
A1  - Orr, M.
A1  - Osborne, J. P.
A1  - Ostrowski, M.
A1  - Otero, L.
A1  - Otte, A. N.
A1  - Ovcharov, E.
A1  - Oya, I.
A1  - Ozieblo, A.
A1  - Paiano, S.
A1  - Pallota, J.
A1  - Panazol, J. L.
A1  - Paneque, D.
A1  - Panter, M.
A1  - Paoletti, R.
A1  - Papyan, G.
A1  - Paredes, J. M.
A1  - Pareschi, G.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pedaletti, G.
A1  - Pepato, A.
A1  - Persic, M.
A1  - Petrucci, P. O.
A1  - Peyaud, B.
A1  - Piechocki, W.
A1  - Pita, S.
A1  - Pivato, G.
A1  - Platos, L.
A1  - Platzer, R.
A1  - Pogosyan, L.
A1  - Pohl, Martin
A1  - Pojmanski, G.
A1  - Ponz, J. D.
A1  - Potter, W.
A1  - Prandini, E.
A1  - Preece, R.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quel, E.
A1  - Quirrenbach, A.
A1  - Rajda, P.
A1  - Rando, R.
A1  - Rataj, M.
A1  - Raue, M.
A1  - Reimann, C.
A1  - Reimann, O.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Renaud, M.
A1  - Renner, S.
A1  - Reymond, J. -M.
A1  - Rhode, W.
A1  - Ribo, M.
A1  - Ribordy, M.
A1  - Rico, J.
A1  - Rieger, F.
A1  - Ringegni, P.
A1  - Ripken, J.
A1  - Ristori, P.
A1  - Rivoire, S.
A1  - Rob, L.
A1  - Rodriguez, S.
A1  - Roeser, U.
A1  - Romano, Patrizia
A1  - Romero, G. E.
A1  - Rosier-Lees, S.
A1  - Rovero, A. C.
A1  - Roy, F.
A1  - Royer, S.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Ruppel, J.
A1  - Russo, F.
A1  - Ryde, F.
A1  - Sacco, B.
A1  - Saggion, A.
A1  - Sahakian, V.
A1  - Saito, K.
A1  - Saito, T.
A1  - Sakaki, N.
A1  - Salazar, E.
A1  - Salini, A.
A1  - Sanchez, F.
A1  - Sanchez Conde, M. A.
A1  - Santangelo, A.
A1  - Santos, E. M.
A1  - Sanuy, A.
A1  - Sapozhnikov, L.
A1  - Sarkar, S.
A1  - Scalzotto, V.
A1  - Scapin, V.
A1  - Scarcioffolo, M.
A1  - Schanz, T.
A1  - Schlenstedt, S.
A1  - Schlickeiser, R.
A1  - Schmidt, T.
A1  - Schmoll, J.
A1  - Schroedter, M.
A1  - Schultz, C.
A1  - Schultze, J.
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwarzburg, S.
A1  - Schweizer, T.
A1  - Seiradakis, J.
A1  - Selmane, S.
A1  - Seweryn, K.
A1  - Shayduk, M.
A1  - Shellard, R. C.
A1  - Shibata, T.
A1  - Sikora, M.
A1  - Silk, J.
A1  - Sillanpaa, A.
A1  - Sitarek, J.
A1  - Skole, C.
A1  - Smith, N.
A1  - Sobczynska, D.
A1  - Sofo Haro, M.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spiga, D.
A1  - Spyrou, S.
A1  - Stamatescu, V.
A1  - Stamerra, A.
A1  - Starling, R. L. C.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steiner, S.
A1  - Stergioulas, N.
A1  - Sternberger, R.
A1  - Stinzing, F.
A1  - Stodulski, M.
A1  - Straumann, U.
A1  - Suarez, A.
A1  - Suchenek, M.
A1  - Sugawara, R.
A1  - Sulanke, K. H.
A1  - Sun, S.
A1  - Supanitsky, A. D.
A1  - Sutcliffe, P.
A1  - Szanecki, M.
A1  - Szepieniec, T.
A1  - Szostek, A.
A1  - Szymkowiak, A.
A1  - Tagliaferri, G.
A1  - Tajima, H.
A1  - Takahashi, H.
A1  - Takahashi, K.
A1  - Takalo, L.
A1  - Takami, H.
A1  - Talbot, R. G.
A1  - Tam, P. H.
A1  - Tanaka, M.
A1  - Tanimori, T.
A1  - Tavani, M.
A1  - Tavernet, J. -P.
A1  - Tchernin, C.
A1  - Tejedor, L. A.
A1  - Telezhinsky, Igor O.
A1  - Temnikov, P.
A1  - Tenzer, C.
A1  - Terada, Y.
A1  - Terrier, R.
A1  - Teshima, M.
A1  - Testa, V.
A1  - Tibaldo, L.
A1  - Tibolla, O.
A1  - Tluczykont, M.
A1  - Peixoto, C. J. Todero
A1  - Tokanai, F.
A1  - Tokarz, M.
A1  - Toma, K.
A1  - Torres, D. F.
A1  - Tosti, G.
A1  - Totani, T.
A1  - Toussenel, F.
A1  - Vallania, P.
A1  - Vallejo, G.
A1  - van der Walt, J.
A1  - van Eldik, C.
A1  - Vandenbroucke, J.
A1  - Vankov, H.
A1  - Vasileiadis, G.
A1  - Vassiliev, V. V.
A1  - Vegas, I.
A1  - Venter, L.
A1  - Vercellone, S.
A1  - Veyssiere, C.
A1  - Vialle, J. P.
A1  - Videla, M.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Vlahakis, N.
A1  - Vlahos, L.
A1  - Vogler, P.
A1  - Vollhardt, A.
A1  - Volpe, F.
A1  - Von Gunten, H. P.
A1  - Vorobiov, S.
A1  - Wagner, S.
A1  - Wagner, R. M.
A1  - Wagner, B.
A1  - Wakely, S. P.
A1  - Walter, P.
A1  - Walter, R.
A1  - Warwick, R.
A1  - Wawer, P.
A1  - Wawrzaszek, R.
A1  - Webb, N.
A1  - Wegner, P.
A1  - Weinstein, A.
A1  - Weitzel, Q.
A1  - Welsing, R.
A1  - Wetteskind, H.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wilkinson, M. I.
A1  - Williams, D. A.
A1  - Winde, M.
A1  - Wischnewski, R.
A1  - Wisniewski, L.
A1  - Wolczko, A.
A1  - Wood, M.
A1  - Xiong, Q.
A1  - Yamamoto, T.
A1  - Yamaoka, K.
A1  - Yamazaki, R.
A1  - Yanagita, S.
A1  - Yoffo, B.
A1  - Yonetani, M.
A1  - Yoshida, A.
A1  - Yoshida, T.
A1  - Yoshikoshi, T.
A1  - Zabalza, V.
A1  - Zagdanski, A.
A1  - Zajczyk, A.
A1  - Zdziarski, A.
A1  - Zech, Alraune
A1  - Zietara, K.
A1  - Ziolkowski, P.
A1  - Zitelli, V.
A1  - Zychowski, P.
T1  - Design concepts for the Cherenkov Telescope Array CTA an advanced facility for ground-based high-energy gamma-ray astronomy
JF  - Experimental astronomy : an international journal on astronomical instrumentation and data analysis
N2  - Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor of 5-10 improvement in sensitivity in the 100 GeV-10 TeV range and the extension to energies well below 100 GeV and above 100 TeV. CTA will consist of two arrays (one in the north, one in the south) for full sky coverage and will be operated as open observatory. The design of CTA is based on currently available technology. This document reports on the status and presents the major design concepts of CTA.
KW  - Ground based gamma ray astronomy
KW  - Next generation Cherenkov telescopes
KW  - Design concepts
Y1  - 2011
U6  - https://doi.org/10.1007/s10686-011-9247-0
SN  - 0922-6435
SN  - 1572-9508
VL  - 32
IS  - 3
SP  - 193
EP  - 316
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Adamovich, Sergey N.
A1  - Mirskova, Anna N.
A1  - Mirskov, Rudolf G.
A1  - Schilde, Uwe
T1  - Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
JF  - Chemistry central journal
N2  - The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR ((1)H, (13)C) technique and by X-ray diffraction analysis. Intermolecular hydrogen bonds between the azonium protons and oxygen atoms of the carboxylate groups were found. Immunoactive properties of the title compound have been screened. The compound has the ability to suppress spontaneous and Con A-stimulated cell proliferation in vitro and therefore can be considered as immunodepressant.
Y1  - 2011
U6  - https://doi.org/10.1186/1752-153X-5-23
SN  - 1752-153X
VL  - 5
IS  - 17
PB  - BioMed Central
CY  - London
ER  - 
TY  - JOUR
A1  - Adelsberger, Joseph
A1  - Meier-Koll, Andreas
A1  - Bivigou Koumba, Achille Mayelle
A1  - Busch, Peter
A1  - Holderer, Olaf
A1  - Hellweg, Thomas
A1  - Laschewsky, André
A1  - Müller-Buschbaum, Peter
A1  - Papadakis, Christine M.
T1  - The collapse transition and the segmental dynamics in concentrated micellar solutions of P(S-b-NIPAM) diblock copolymers
JF  - Colloid and polymer science : official journal of the Kolloid-Gesellschaft
N2  - We investigate concentrated solutions of poly(styrene-b-N-isopropyl acrylamide) (P(S-b-NIPAM)) diblock copolymers in deuterated water (D2O). Both structural changes and the changes of the segmental dynamics occurring upon heating through the lower critical solution temperature (LCST) of PNIPAM are studied using small-angle neutron scattering and neutron spin-echo spectroscopy. The collapse of the micellar shell and the cluster formation of collapsed micelles at the LCST as well as an increase of the segmental diffusion coefficient after crossing the LCST are detected. Comparing to our recent results on a triblock copolymer P(S-b-NIPAM-b-S) [25], we observe that the collapse transition of P(S-b-NIPAM) is more complex and that the PNIPAM segmental dynamics are faster than in P(S-b-NIPAM-b-S).
KW  - Block copolymers
KW  - Responsive polymers
KW  - Small-angle neutron scattering
KW  - Neutron spin-echo spectroscopy
Y1  - 2011
U6  - https://doi.org/10.1007/s00396-011-2382-3
SN  - 0303-402X
VL  - 289
IS  - 5-6
SP  - 711
EP  - 720
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Ahnert, Karsten
A1  - Abel, Markus
A1  - Kollosche, Matthias
A1  - Jorgensen, Per Jorgen
A1  - Kofod, Guggi
T1  - Soft capacitors for wave energy harvesting
JF  - Journal of materials chemistry
N2  - Wave energy harvesting could be a substantial renewable energy source without impact on the global climate and ecology, yet practical attempts have struggled with the problems of wear and catastrophic failure. An innovative technology for ocean wave energy harvesting was recently proposed, based on the use of soft capacitors. This study presents a realistic theoretical and numerical model for the quantitative characterization of this harvesting method. Parameter regions with optimal behavior are found, and novel material descriptors are determined, which dramatically simplify analysis. The characteristics of currently available materials are evaluated, and found to merit a very conservative estimate of 10 years for raw material cost recovery.
Y1  - 2011
U6  - https://doi.org/10.1039/c1jm12454d
SN  - 0959-9428
SN  - 1364-5501
VL  - 21
IS  - 38
SP  - 14492
EP  - 14497
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Akal, Cuneyt
A1  - Koralay, O. Ersin
A1  - Candan, Osman
A1  - Oberhänsli, Roland
A1  - Chen, Fukun
T1  - Geodynamic significance of the early triassic karaburun granitoid (Western Turkey) for the opening history of Neo-Tethys
JF  - Turkish journal of earth sciences = Türk yerbilimleri dergisi
N2  - The Karaburun Peninsula, which is considered part of the Anatolide-Tauride Block of Turkey, contains clastic and carbonate sequences deposited on the northern margin of Gondwana. The Palaeozoic clastic sequence, which is intruded by the Early Triassic granitoid and tectonically overlies a Mesozoic melange sequence, can be divided into three subunits: a lower clastic subunit consisting of a sandstone-shale alternation, an upper clastic subunit consisting of black chert-bearing shales, sandstone and conglomerate, and a Permo-Carboniferous carbonate subunit. The lower Triassic Karaburun I-type granitoid has a high initial Sr-87/Sr-86 ratio (0.709021-0.709168), and low Nd-143/Nd-144 ratio (0.512004-0.512023) and epsilon Nd (-5.34 to -5.70) isotopic values. Geochronological data indicate a crystallization (intrusion) age of 247.1 +/- 2.0 Ma (Scythian). Geochemically, the acidic magmatism reflects a subduction-related continental-arc basin tectonic setting, which can be linked to the opening of the northern branch of Neo-Tethys as a continental back-arc rifting basin on the northern margin of Gondwana. This can be related to the closure through southward subduction of the Palaeotethys Ocean beneath Gondwana.
KW  - Karaburun
KW  - Neo-Tethys
KW  - Palaeo-Tethys
KW  - diorite
KW  - Triassic
KW  - magmatism
Y1  - 2011
U6  - https://doi.org/10.3906/yer-1008-1
SN  - 1300-0985
VL  - 20
IS  - 3
SP  - 255
EP  - 271
PB  - Tübitak
CY  - Ankara
ER  - 
TY  - JOUR
A1  - Aksu, Yilmaz
A1  - Frasca, Stefano
A1  - Wollenberger, Ursula
A1  - Driess, Matthias
A1  - Thomas, Arne
T1  - A molecular precursor approach to tunable porous tin-rich indium tin oxide with durable high electrical conductivity for bioelectronic devices
JF  - Chemistry of materials : a publication of the American Chemical Society
N2  - The preparation of porous, i.e., high surface area electrodes from transparent conducting oxides, is a valuable goal in materials chemistry as such electrodes can enable further development of optoelectronic, electrocatalytic, or bioelectronic devices. In this work the first tin-rich mesoporous indium tin oxide is prepared using the molecular heterobimetallic single-source precursor, indium tin tris-tert-butoxide, together with an appropriate structure-directing template, yielding materials with high surface areas and tailorable pore size. The resulting mesoporous tin-rich ITO films show a high and durable electrical conductivity and transparency, making them interesting materials for hosting electroactive biomolecules such as proteins. In fact, its unique performance in bioelectronic applications has been demonstrated by immobilization of high amounts of cytochrome c into the mesoporous film which undergo redox processes directly with the conductive electrode material.
KW  - indium tin oxide ITO
KW  - electrode
KW  - bioelectrochemistry
KW  - device
KW  - cytochrome c
Y1  - 2011
U6  - https://doi.org/10.1021/cm103087p
SN  - 0897-4756
VL  - 23
IS  - 7
SP  - 1798
EP  - 1804
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Albeck-Gidron, Rachel
T1  - The Holocaust as a Changing Presence in Yoel Hoffmann’s Texts
JF  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V.
N2  - Yoel Hoffmann is an Israeli writer born in 1937 in Brasov (Kronstadt), Romania. Brought up in a German-speaking family, already in his first book, Sefer Yosef (1989), he conveys the voice of German-speaking immigrants in Israel (the “Katschen” story, 1986) and that of the East European Jewish community in Berlin in the late 1930s, on the verge of the Second World War. His works are crammed with characters of Jews from Germany gripped by the memory of the language they abandoned following their emigration to Palestine in the 1930s. The classic one is the character of Bernhard, in the eponymous work. The current article focuses on the representation and elaboration of Hoffmann’s unique creation, in a language influenced by his deep identification with Zen Buddhism on the one hand, and his attraction to the modernist, Western style of stream of consciousness on the other. In central sections of his works, Hoffman presents his entire literary corpus as a type of explicit, allusive, or secret Holocaust literature, and invites his readers and his critics to decode the allusions and expose the secret in this theme, a surprising statement in relation to Hoffmann’s work and its analysis so far. Hoffmann represents the Holocaust as a collective Israeli trauma for which his literary fiction creates a special catalogue of representative characters. In the creation of a catalogue, and particularly one that simultaneously classifies and individualizes, Hoffmann’s project resembles the monumental 1920s cataloguing project by the celebrated German photographer August Sander (Menschen des 20. Jahrhunderts). Hoffmann included photographs from this project in his works, and even chose some of them for the covers of his books. The article examines the implicit relationships between these two creative artists as conferring a meaning so far not considered in the research of the Holocaust theme in Yoel Hoffmann’s writings.
N2  - Yoel Hoffmann ist ein israelischer Autor, der 1937 in Brasov (Kronstadt), Rumänien geboren wurde. Er wuchs in einer deutschsprachigen Familie auf. Bereits in seinem ersten Buch Sefer Yosef (1989) verleiht er den deutschsprachigen Immigranten in Israel (die „Katschen”-Geschichte, 1986) und der osteuropäisch-jüdischen Gemeinschaft im Berlin der späten 1930er Jahre vor Ausbruch des Zweiten Weltkriegs eine Stimme. Sein Werk ist mit jüdischen Protagonisten aus Deutschland gespickt, die von der Erinnerung an die Sprache erfasst sind, von der sie sich seit ihrer Emigration nach Palästina in den 1930er Jahren zu lösen versuchen. Ein klassisches Beispiel hierfür ist die Figur des Bernhard in Hoffmanns gleichnamigem Werk. Der folgende Artikel fokussiert die Darstellungsweise und Ausarbeitung von Hoffmanns einzigartigem Werk, dessen Sprache einerseits durch seine tiefe Identifikation mit dem Zen Buddhismus und andererseits durch einen den Autor anziehenden, modernistischen westlichen Stil des Bewusstseinsstroms beeinflusst wurde. In zentralen Teilen seines Werkes stellt Hoffmann seinen gesamten literarischen Textkorpus als einen Typus der expliziten, anspielenden oder aber verborgenen Holocaust-Literatur dar. Er lädt seine Leserschaft und seine Kritiker dazu ein, seine Anspielungen zu dechiffrieren und das Geheimnis seiner Themen aufzudecken. Dies ist eine überraschende Aussage in Bezug auf Hoffmanns Werk und dessen bisherige Analyse. Der Autor stellt den Holocaust als ein kollektives israelisches Trauma dar, für das seine literarische Fiktion einen speziellen Katalog repräsentativer Charaktere erstellt hat. Bei der Erstellung dieses Katalogs, dies insbesondere da er zeitgleich klassifiziert und individualisiert, ähnelt Hoffmanns Projekt dem monumentalen Katalogisierungsprojekt der 1920er Jahre, das von dem gefeierten deutschen Fotografen August Sander (Menschen des 20. Jahrhunderts) durchgeführt wurde. Hoffmann bezieht Fotografien aus Sanders Projekt in sein Werk ein und verwendet sogar einige der Abbildungen für die Titelseite seiner Bücher. Der Artikel behandelt die implizite Beziehung zwischen diesen beiden kreativen Künstlern und lässt diesem Aspekt eine Bedeutung zuteil werden, die bislang in der Forschung über Holocaust Themen in Yoel Hoffmanns schriftstellerischem Werk keinen Niederschlag fand.
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-53307
SN  - 1614-6492
SN  - 1862-7684
IS  - 17
SP  - 175
EP  - 207
ER  - 
TY  - JOUR
A1  - Albert, Cécile H.
A1  - Grassein, Fabrice
A1  - Schurr, Frank Martin
A1  - Vieilledent, Ghislain
A1  - Violle, Cyrille
T1  - When and how should intraspecific variability be considered in trait-based plant ecology?
JF  - Perspectives in plant ecology, evolution and systematics
N2  - Trait-based studies have become extremely common in plant ecology. Trait-based approaches often rely on the tacit assumption that intraspecific trait variability (ITV) is negligible compared to interspecific variability, so that species can be characterized by mean trait values. Yet, numerous recent studies have challenged this assumption by showing that ITV significantly affects various ecological processes. Accounting for ITV may thus strengthen trait-based approaches, but measuring trait values on a large number of individuals per species and site is not feasible. Therefore, it is important and timely to synthesize existing knowledge on ITV in order to (1) decide critically when ITV should be considered, and (2) establish methods for incorporating this variability. Here we propose a practical set of rules to identify circumstances under which ITV should be accounted for. We formulate a spatial trait variance partitioning hypothesis to highlight the spatial scales at which ITV cannot be ignored in ecological studies. We then refine a set of four consecutive questions on the research question, the spatial scale, the sampling design, and the type of studied traits, to determine case-by-case if a given study should quantify ITV and test its effects. We review methods for quantifying ITV and develop a step-by-step guideline to design and interpret simulation studies that test for the importance of ITV. Even in the absence of quantitative knowledge on ITV, its effects can be assessed by varying trait values within species within realistic bounds around the known mean values. We finish with a discussion of future requirements to further incorporate ITV within trait-based approaches. This paper thus delineates a general framework to account for ITV and suggests a direction towards a more quantitative trait-based ecology.
KW  - Comparative ecology
KW  - Functional ecology
KW  - Genetic variability
KW  - Intraspecific functional variability
KW  - Phenotypic plasticity
KW  - Plant functional hairs
KW  - Within-species variability
Y1  - 2011
U6  - https://doi.org/10.1016/j.ppees.2011.04.003
SN  - 1433-8319
VL  - 13
IS  - 3
SP  - 217
EP  - 225
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Albrecht, Tanja
A1  - Martin, M.
A1  - Haseloff, M.
A1  - Winkelmann, Ricarda
A1  - Levermann, Anders
T1  - Parameterization for subgrid-scale motion of ice-shelf calving fronts
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - A parameterization for the motion of ice-shelf fronts on a Cartesian grid in finite-difference land-ice models is presented. The scheme prevents artificial thinning of the ice shelf at its edge, which occurs due to the finite resolution of the model. The intuitive numerical implementation diminishes numerical dispersion at the ice front and enables the application of physical boundary conditions to improve the calculation of stress and velocity fields throughout the ice-sheet-shelf system. Numerical properties of this subgrid modification are assessed in the Potsdam Parallel Ice Sheet Model (PISM-PIK) for different geometries in one and two horizontal dimensions and are verified against an analytical solution in a flow-line setup.
Y1  - 2011
U6  - https://doi.org/10.5194/tc-5-35-2011
SN  - 1994-0416
VL  - 5
IS  - 1
SP  - 35
EP  - 44
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Aliu, E.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Boettcher, Markus
A1  - Bouvier, A.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Huan, H.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Madhavan, A. S.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pichel, A.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Ruppel, J.
A1  - Saxon, D. B.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Skole, C.
A1  - Smith, A. W.
A1  - Staszak, D.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Tyler, J.
A1  - Varlotta, A.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
T1  - Veritas observations of unusual extragalactic transient swift J164449.3+573451
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters
N2  - We report on very high energy (>100 GeV) gamma-ray observations of Swift J164449.3+573451, an unusual transient object first detected by the Swift Observatory and later detected by multiple radio, optical, and X-ray observatories. A total exposure of 28 hr was obtained on Swift J164449.3+573451 with the Very Energetic Radiation Imaging Telescope Array System ( VERITAS) during 2011 March 28-April 15. We do not detect the source and place a differential upper limit on the emission at 500 GeV during these observations of 1.4 x 10(-12) erg cm(-2) s(-1) (99% confidence level). We also present time-resolved upper limits and use a flux limit averaged over the X-ray flaring period to constrain various emission scenarios that can accommodate both the radio-through-X-ray emission detected from the source and the lack of detection by VERITAS.
KW  - accretion, accretion disks
KW  - galaxies: active
KW  - gamma rays: galaxies
KW  - radiation mechanisms: non-thermal
Y1  - 2011
U6  - https://doi.org/10.1088/2041-8205/738/2/L30
SN  - 2041-8205
VL  - 738
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Aliu, E.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Bouvier, A.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Byrum, K.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Christiansen, J. L.
A1  - Ciupik, L.
A1  - Collins-Hughes, E.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Duke, C.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gibbs, K.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Huan, H.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Imran, A.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Lyutikov, M.
A1  - Madhavan, A. S.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - McArthur, S.
A1  - McCann, A.
A1  - McCutcheon, M.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Nunez, P.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pizlo, F.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Ruppel, J.
A1  - Saxon, D. B.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Sentuerk, G. D.
A1  - Smith, A. W.
A1  - Staszak, D.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Tyler, J.
A1  - Varlotta, A.
A1  - Vassiliev, V. V.
A1  - Vincent, S.
A1  - Vivier, M.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Zitzer, B.
T1  - Detection of pulsed Gamma Rays Above 100 GeV from the Crab Pulsar
JF  - Science
N2  - We report the detection of pulsed gamma rays from the Crab pulsar at energies above 100 giga-electron volts (GeV) with the Very Energetic Radiation Imaging Telescope Array System (VERITAS) array of atmospheric Cherenkov telescopes. The detection cannot be explained on the basis of current pulsar models. The photon spectrum of pulsed emission between 100 mega-electron volts and 400 GeV is described by a broken power law that is statistically preferred over a power law with an exponential cutoff. It is unlikely that the observation can be explained by invoking curvature radiation as the origin of the observed gamma rays above 100 GeV. Our findings require that these gamma rays be produced more than 10 stellar radii from the neutron star.
Y1  - 2011
U6  - https://doi.org/10.1126/science.1208192
SN  - 0036-8075
VL  - 334
IS  - 6052
SP  - 69
EP  - 72
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Aliu, E.
A1  - Aune, T.
A1  - Beilicke, M.
A1  - Benbow, W.
A1  - Boettcher, Markus
A1  - Bouvier, A.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Connolly, M. P.
A1  - Cui, W.
A1  - Decerprit, G.
A1  - Dickherber, R.
A1  - Duke, C.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Feng, Q.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Griffin, S.
A1  - Grube, J.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Hivick, B.
A1  - Holder, J.
A1  - Huan, H.
A1  - Hughes, G.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Maier, G.
A1  - Majumdar, P.
A1  - McArthur, S.
A1  - McCann, A.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Nelson, T.
A1  - Ong, R. A.
A1  - Orr, M.
A1  - Otte, A. N.
A1  - Park, N.
A1  - Perkins, J. S.
A1  - Pichel, A.
A1  - Pohl, Martin
A1  - Prokoph, H.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Ruppel, J.
A1  - Saxon, D. B.
A1  - Sembroski, G. H.
A1  - Skole, C.
A1  - Smith, A. W.
A1  - Staszak, D.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Tsurusaki, K.
A1  - Tyler, J.
A1  - Varlotta, A.
A1  - Vassiliev, V. V.
A1  - Wakely, S. P.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Williams, D. A.
A1  - Zitzer, B.
A1  - Ciprini, S.
A1  - Fumagalli, M.
A1  - Kaplan, K.
A1  - Paneque, D.
A1  - Prochaska, J. X.
T1  - Multiwavelenght observations of the previously unidentified blzar RX J0648.7+1516
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We report on the VERITAS discovery of very high energy (VHE) gamma-ray emission above 200 GeV from the high-frequency-peaked BL Lac (HBL) object RX J0648.7+1516 (GB J0648+1516), associated with 1FGL J0648.8+1516. The photon spectrum above 200 GeV is fitted by a power law dN/dE = F-0(E/E-0)(-Gamma) with a photon index Gamma of 4.4 +/- 0.8(stat) +/- 0.3(syst) and a flux normalization F-0 of (2.3 +/- 0.5(stat) +/- 1.2(sys)) x 10(-11) TeV-1 cm(-2) s(-1) with E-0 = 300 GeV. No VHE variability is detected during VERITAS observations of RX J0648.7+1516 between 2010 March 4 and April 15. Following the VHE discovery, the optical identification and spectroscopic redshift were obtained using the Shane 3 m Telescope at the Lick Observatory, showing the unidentified object to be a BL Lac type with a redshift of z = 0.179. Broadband multiwavelength observations contemporaneous with the VERITAS exposure period can be used to subclassify the blazar as an HBL object, including data from the MDM observatory, Swift-UVOT, and X-Ray Telescope, and continuous monitoring at photon energies above 1 GeV from the Fermi Large Area Telescope (LAT). We find that in the absence of undetected, high-energy rapid variability, the one-zone synchrotron self-Compton (SSC) model overproduces the high-energy gamma-ray emission measured by the Fermi-LAT over 2.3 years. The spectral energy distribution can be parameterized satisfactorily with an external-Compton or lepto-hadronic model, which have two and six additional free parameters, respectively, compared to the one-zone SSC model.
KW  - BL Lacertae objects: individual (RX J0648.7+1516, 1FGL J0648.8+1516, VER J0648+152)
KW  - gamma rays: galaxies
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/742/2/127
SN  - 0004-637X
VL  - 742
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - THES
A1  - Alnemr, Rehab
T1  - Reputation object representation model for enabling reputation interoperability
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - GEN
A1  - Alter, Markus L.
A1  - Ott, Ina
A1  - von Websky, Karoline
A1  - Tsuprykov, Oleg
A1  - Sharkovska, Yuliya
A1  - Krause-Relle, Katharina
A1  - Raila, Jens
A1  - Henze, Andrea
A1  - Kretschmer, Axel
A1  - Stasch, Johannes-Peter
A1  - Hocher, Berthold
T1  - Additional stimulation of sGC on top of standard treatment with ARB`s may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Background

Riociguat is the first of a new class of drugs, the soluble guanylate cyclase (sGC) stimulators. Riociguat has a dual mode of action: it sensitizes sGC to the body’s own NO and can also increase sGC activity in the absence of NO. The NO-sGC-pathway is impaired in many cardiovascular diseases such as heart failure, pulmonary hypertension and diabetic nephropathy (DN). DN leads to high cardiovascular morbidity and mortality. There is still a high unmet medical need. The urinary albumin excretion rate is a predictive biomarker for these clinical events. Therefore, we investigated the effect of riociguat, alone and in combination with the angiotensin II receptor antagonist (ARB) telmisartan on the progression of DN in diabetic eNOS knock out mice, a new model closely resembling human pathology.

Methods

Seventy-six male eNOS knockout C57BL/6J mice were divided into 4 groups after receiving intraperitoneal high-dose streptozotocin: telmisartan (1 mg/kg), riociguat (3 mg/kg), riociguat+telmisartan (3 and 1 mg/kg), and vehicle. Fourteen mice were used as non-diabetic controls. After 12 weeks, urine and blood were obtained and blood pressure measured. Glucose concentrations were highly increased and similar in all diabetic groups.

Results

Riociguat, alone (105.2 ± 2.5 mmHg; mean±SEM; n = 14) and in combination with telmisartan (105.0 ± 3.2 mmHg; n = 12), significantly reduced blood pressure versus diabetic controls (117.1 ± 2.2 mmHg; n = 14; p = 0.002 and p = 0.004, respectively), whereas telmisartan alone (111.2 ± 2.6 mmHg) showed a modest blood pressure lowering trend (p = 0.071; n = 14). The effects of single treatment with either riociguat (97.1 ± 15.7 µg/d; n = 13) or telmisartan (97.8 ± 26.4 µg/d; n = 14) did not significantly lower albumin excretion on its own (p = 0.067 and p = 0.101, respectively). However, the combined treatment led to significantly lower urinary albumin excretion (47.3 ± 9.6 µg/d; n = 12) compared to diabetic controls (170.8 ± 34.2 µg/d; n = 13; p = 0.004), and reached levels similar to non-diabetic controls (31.4 ± 10.1 µg/d, n = 12).

Conclusion

Riociguat significantly reduced urinary albumin excretion in diabetic eNOS knock out mice that were refractory to treatment with ARB’s alone. Patients with diabetic nephropathy refractory to treatment with ARB’s have the worst prognosis among all patients with diabetic nephropathy. Our data indicate that additional stimulation of sGC on top of standard treatment with ARB`s may offer a new therapeutic approach for patients with diabetic nephropathy resistant to ARB treatment.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 855 
KW  - pulmonary hypertension
KW  - diabetic nephropathy
KW  - diabetic control
KW  - telmisartan
KW  - guanylate cyclase
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-428250
SN  - 1866-8372
IS  - 855
ER  - 
TY  - THES
A1  - Andorf, Sandra
T1  - A systems biological approach towards the molecular basis of heterosis in Arabidopsis thaliana
T1  - Ein systembiologischer Ansatz für das Verständnis der molekularen Grundlagen von Heterosis in Arabidopsis thaliana
N2  - Heterosis is defined as the superiority in performance of heterozygous genotypes compared to their corresponding genetically different homozygous parents. This phenomenon is already known since the beginning of the last century and it has been widely used in plant breeding, but the underlying genetic and molecular mechanisms are not well understood. In this work, a systems biological approach based on molecular network structures is proposed to contribute to the understanding of heterosis. Hybrids are likely to contain additional regulatory possibilities compared to their homozygous parents and, therefore, they may be able to correctly respond to a higher number of environmental challenges, which leads to a higher adaptability and, thus, the heterosis phenomenon. In the network hypothesis for heterosis, presented in this work, more regulatory interactions are expected in the molecular networks of the hybrids compared to the homozygous parents. Partial correlations were used to assess this difference in the global interaction structure of regulatory networks between the hybrids and the homozygous genotypes. This network hypothesis for heterosis was tested on metabolite profiles as well as gene expression data of the two parental Arabidopsis thaliana accessions C24 and Col-0 and their reciprocal crosses. These plants are known to show a heterosis effect in their biomass phenotype. The hypothesis was confirmed for mid-parent and best-parent heterosis for either hybrid of our experimental metabolite as well as gene expression data. It was shown that this result is influenced by the used cutoffs during the analyses. Too strict filtering resulted in sets of metabolites and genes for which the network hypothesis for heterosis does not hold true for either hybrid regarding mid-parent as well as best-parent heterosis. In an over-representation analysis, the genes that show the largest heterosis effects according to our network hypothesis were compared to genes of heterotic quantitative trait loci (QTL) regions. Separately for either hybrid regarding mid-parent as well as best-parent heterosis, a significantly larger overlap between the resulting gene lists of the two different approaches towards biomass heterosis was detected than expected by chance. This suggests that each heterotic QTL region contains many genes influencing biomass heterosis in the early development of Arabidopsis thaliana. Furthermore, this integrative analysis led to a confinement and an increased confidence in the group of candidate genes for biomass heterosis in Arabidopsis thaliana identified by both approaches.
N2  - Als Heterosis-Effekt wird die Überlegenheit in einem oder mehreren Leistungsmerkmalen (z.B. Blattgröße von Pflanzen) von heterozygoten (mischerbigen) Nachkommen über deren unterschiedlich homozygoten (reinerbigen) Eltern bezeichnet. Dieses Phänomen ist schon seit Beginn des letzten Jahrhunderts bekannt und wird weit verbreitet in der Pflanzenzucht genutzt. Trotzdem sind die genetischen und molekularen Grundlagen von Heterosis noch weitestgehend unbekannt. Es wird angenommen, dass heterozygote Individuen mehr regulatorische Möglichkeiten aufweisen als ihre homozygoten Eltern und sie somit auf eine größere Anzahl an wechselnden Umweltbedingungen richtig reagieren können. Diese erhöhte Anpassungsfähigkeit führt zum Heterosis-Effekt. In dieser Arbeit wird ein systembiologischer Ansatz, basierend auf molekularen Netzwerkstrukturen verfolgt, um zu einem besseren Verständnis von Heterosis beizutragen. Dazu wird eine Netzwerkhypothese für Heterosis vorgestellt, die vorhersagt, dass die heterozygoten Individuen, die Heterosis zeigen, mehr regulatorische Interaktionen in ihren molekularen Netzwerken aufweisen als die homozygoten Eltern. Partielle Korrelationen wurden verwendet, um diesen Unterschied in den globalen Interaktionsstrukturen zwischen den Heterozygoten und ihren homozygoten Eltern zu untersuchen. Die Netzwerkhypothese wurde anhand von Metabolit- und Genexpressionsdaten der beiden homozygoten Arabidopsis thaliana Pflanzenlinien C24 und Col-0 und deren wechselseitigen Kreuzungen getestet. Arabidopsis thaliana Pflanzen sind bekannt dafür, dass sie einen Heterosis-Effekt im Bezug auf ihre Biomasse zeigen. Die heterozygoten Pflanzen weisen bei gleichem Alter eine höhere Biomasse auf als die homozygoten Pflanzen. Die Netzwerkhypothese für Heterosis konnte sowohl im Bezug auf mid-parent Heterosis (Unterschied in der Leistung des Heterozygoten im Vergleich zum Mittelwert der Eltern) als auch auf best-parent Heterosis (Unterschied in der Leistung des Heterozygoten im Vergleich zum Besseren der Eltern) für beide Kreuzungen für die Metabolit- und Genexpressionsdaten bestätigt werden. In einer Überrepräsentations-Analyse wurden die Gene, für die die größte Veränderung in der Anzahl der regulatorischen Interaktionen, an denen sie vermutlich beteiligt sind, festgestellt wurde, mit den Genen aus einer quantitativ genetischen (QTL) Analyse von Biomasse-Heterosis in Arabidopsis thaliana verglichen. Die ermittelten Gene aus beiden Studien zeigen eine größere Überschneidung als durch Zufall erwartet. Das deutet darauf hin, dass jede identifizierte QTL-Region viele Gene, die den Biomasse-Heterosis-Effekt in Arabidopsis thaliana beeinflussen, enthält. Die Gene, die in den Ergebnislisten beider Analyseverfahren überlappen, können mit größerer Zuversicht als Kandidatengene für Biomasse-Heterosis in Arabidopsis thaliana betrachtet werden als die Ergebnisse von nur einer Studie.
KW  - Systembiologie
KW  - Heterosis
KW  - Molekulare Profildaten
KW  - Integrative Analyse
KW  - Systems biology
KW  - Heterosis
KW  - Molecular profile data
KW  - Integrative analysis
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-51173
ER  - 
TY  - THES
A1  - Andrade Linares, Diana Rocío
T1  - Characterization of tomato root-endophytic fungi and analysis of their effects on plant development, on fruit yield and quality and on interaction with the pathogen Verticillium dahliae
T1  - Charakterisierung wurzelendophytischer Pilze von Tomate und Analyse ihrer Effekte auf Pflanzenentwicklung, auf Ertrag und Fruchtqualität und auf die Wechselwirkung mit dem Pathogen Verticillium dahliae
N2  - Non-mycorrhizal fungal endophytes are able to colonize internally roots without causing visible disease symptoms establishing neutral or mutualistic associations with plants. These fungi known as non-clavicipitaceous endophytes have a broad host range of monocot and eudicot plants and are highly diverse. Some of them promote plant growth and confer increased abiotic-stress tolerance and disease resistance. According to such possible effects on host plants, it was aimed to isolate and to characterize native fungal root endophytes from tomato (Lycopersicon esculentum Mill.) and to analyze their effects on plant development, plant resistance and fruit yield and quality together with the model endophyte Piriformospora indica. Fifty one new fungal strains were isolated from desinfected tomato roots of four different crop sites in Colombia. These isolates were roughly characterized and fourteen potential endophytes were further analyzed concerning their taxonomy, their root colonization capacity and their impact on plant growth. Sequencing of the ITS region from the ribosomal RNA gene cluster and in-depth morphological characterisation revealed that they correspond to different phylogenetic groups among the phylum Ascomycota. Nine different morphotypes were described including six dark septate endophytes (DSE) that did not correspond to the Phialocephala group. Detailed confocal microscopy analysis showed various colonization patterns of the endophytes inside the roots ranging from epidermal penetration to hyphal growth through the cortex. Tomato pot experiments under glass house conditions showed that they differentially affect plant growth depending on colonization time and inoculum concentration. Three new isolates (two unknown fungal endophyte DSE48, DSE49 and one identified as Leptodontidium orchidicola) with neutral or positiv effects were selected and tested in several experiments for their influence on vegetative growth, fruit yield and quality and their ability to diminish the impact of the pathogen Verticillium dahliae on tomato plants. Although plant growth promotion by all three fungi was observed in young plants, vegetative growth parameters were not affected after 22 weeks of cultivation except a reproducible increase of root diameter by the endophyte DSE49. Additionally, L. orchidicola increased biomass and glucose content of tomato fruits, but only at an early date of harvest and at a certain level of root colonization. Concerning bioprotective effects, the endophytes DSE49 and L. orchidicola decreased significantly disease symptoms caused by the pathogen V. dahliae, but only at a low dosis of the pathogen. In order to analyze, if the model root endophytic fungus Piriformospora indica could be suitable for application in production systems, its impact on tomato was evaluated. Similarly to the new fungal isolates, significant differences for vegetative growth parameters were only observable in young plants and, but protection against V. dahliae could be seen in one experiment also at high dosage of the pathogen. As the DSE L. orchidicola, P. indica increased the number and biomass of marketable tomatoes only at the beginning of fruit setting, but this did not lead to a significant higher total yield. If the effects on growth are due to a better nutrition of the plant with mineral element was analyzed in barley in comparison to the arbuscular mycorrhizal fungus Glomus mosseae. While the mycorrhizal fungus increased nitrogen and phosphate uptake of the plant, no such effect was observed for P. indica. In summary this work shows that many different fungal endophytes can be also isolated from roots of crops and, that these isolates can have positive effects on early plant development. This does, however, not lead to an increase in total yield or in improvement of fruit quality of tomatoes under greenhouse conditions.
N2  - Endophyten, die nicht zu den Mykorrhizapilzen gehören, können das Innere von Wurzeln ohne sichtbare Krankheitssymptome besiedeln und bilden so mit der Pflanze neutrale oder mutualistische Wechselwirkungen. Diese Pilze, auch als nicht-clavicipetale Endophyten bekannt, haben ein breites Wirtsspektrum von mono- und dikotyledonen Pflanzen und weisen eine hohe Diversität auf. Einige von ihnen fördern Pflanzenwachstum und erhöhen Resistenz und Toleranz gegenüber biotischem und abiotischem Stress. Ausgehenden von diesen möglichen Effekten auf ihre Wirtspflanzen war das Ziel der vorliegenden Arbeit die Isolierung und Charakterisierung neuer pilzlicher Wurzelendophyten der Tomate (Lycopersicon esculentum Mill.) und die Analyse ihres Einflusses auf Pflanzenentwicklung und Pflanzenresistenz, sowie auf Ertrag und Fruchtqualität unter Einbeziehung des Modellendophyten Piriformospora indica. Aus vier verschiedenen Anbaugebieten in Kolumbien konnten 51 neue Pilzstämme von oberflächensterilisierten Tomatenwurzeln isoliert werden. Diese Isolate wurden vorcharakterisiert und 14 potentielle Endophyten bezüglich ihrer Taxonomie, ihrer Besiedlungsmuster und ihres Einfluss auf das Pflanzenwachstum näher untersucht. Sequenzierung der ITS Region des ribosomalen RNA Genclusters und genaue morphologische Charakterisierung zeigten, dass sie zu verschiedenen phylogenetischen Gruppen innerhalb der Ascomycota gehören. Neun Morphotypen ließen sich beschreiben, wobei sechs zu den ‚Dark Septate Endophytes’ (DSEs) gehören, aber nicht mit der bekannten Phialocephala Gruppe verwandt waren. Ausführliche konfokale mikroskopische Untersuchungen ergaben sehr verschiedene Besiedelungsmuster der Wurzelendophyten vom Endringen in die Epidermis bis zum Hyphenwachstum durch den Kortex. Topfexperimente unter Gewächshausbedingungen zeigten dass die Isolate in Abhängigkeit von der Inokulumkonzentration und der Zeit der Besiedlung das Wachstum der Tomaten sehr unterschiedlich beeinflussten. Drei neue Isolate (die beiden unbekannte pilzlichen Endophyten DSE48 und DSE49 und eines identifiziert als Leptodontidium orchidicola) mit neutralen oder positiven Effekten wurden für weitere Versuche ausgewählt. In mehreren Experimenten sollte ihr Einfluss auf das vegetative Wachstum, auf Ertrag und auf Fruchtqualität untersucht werden, sowie ihre Fähigkeit die Auswirkungen des Pathogens Verticillium dahliae auf Tomatenpflanzen zu vermindern. Obwohl wachstumsfördernde Effekte durch alle drei Pilze in jungen Pflanzen beobachtet wurden, waren vegetative Wachstumsparameter nach 22 Wochen der Besiedlung nicht mehr beeinflusst bis auf ein signifikante Erhöhung des Wurzeldurchmessers durch den Endophyten DSE49. L. orchidicola dagegen erhöhte die Biomasse und den Glukosegehalt der Früchte, aber nur zu frühen Ernteterminen und bei einer bestimmten Intensität der Wurzelbesiedelung. Hinsichtlich eines schützenden Effekts, konnten die Endophyten DSE49 und L. orchidicola die Krankheitssymptome, die durch V. dahliae verursacht wurden, vermindern, aber nur bei einem geringen Pathogendruck. Um zu überprüfen, ob der Modellendophyt P. indica in Produktionssytemen eingesetzt werden kann, wurde seine Auswirkungen auf Tomaten untersucht. Ähnlich wie die neuen pilzlichen Isolate, zeigte aber auch er seinen fördernden Einfluss nur auf das frühe vegetative Wachstum. Schützende Effekte gegen V. dahliae konnten ebenfalls nur bei niedrigem Pathogendruck konstant beobachtet werden. Wie L. orchidicola erhöhte P. indica die Biomasse an marktfähigen Tomaten am Anfang des Fruchtansatzes, was nicht zu einem insgesamt höheren Ertrag führte. Ob die beobachteten Effekte auf ein verbesserte Nährstoffversorgung der Pflanze zurückzuführen seien, wurde in Gerste im Vergleich mit dem arbuskulären Mykorrhizapilz Glomus mosseae untersucht. Während der Mykorrhizapilz sowohl Phosphat wie Stickstoffaufnehme der Pflanze erhöhte, konnte dies für P. indica nicht festgestellt werden. Zusammenfassend zeigt diese Arbeit, dass auch aus Wurzeln von Kulturpflanzen viele verschiedene pilzliche Endophyten isoliert werden können, und dass einige von diesen durchaus einen positiven Effekt auf die frühe Pflanzenentwicklung aufweisen. Zumindest für Tomate unter Gewächshausbedingungen führen diese Effekte aber nicht zu einer Erhöhung des Gesamtertrags oder einer nachhaltigen Verbesserung der Fruchtqualität.
KW  - Pilz-Endophyten
KW  - Ascomycota
KW  - Wurzelbesiedlung
KW  - Tomaten (Solanum lycopersicum)
KW  - Pflanze-Pilz-Interaktionen
KW  - Fungal endophyte
KW  - Ascomycota
KW  - root colonization
KW  - tomato (Solanum lycopersicum)
KW  - plant-fungal interactions
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-51375
ER  - 
TY  - RPRT
A1  - Andree, Kai
T1  - Collusion in spatially separated markets with quantity competition
N2  - This paper develops the incentives to collude in a model with spatially separated markets and quantity setting firms. We find that increases in transportation costs stabilize the collusive agreement. We also show that, the higher the demand in both markets the less likely will collusion be sustained. Gross and Holahan (2003) use a similar model with price setting firms, we compare their results with ours to analyze the impact of the mode of competition on sustainability of collusion. Further we analyze the impact of collusion on social welfare and find that collusion may be welfare enhancing.
T3  - Volkswirtschaftliche Diskussionsbeiträge - 104 
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-55927
ER  - 
TY  - JOUR
A1  - Antoniou, Stella
A1  - Pashalidis, I.
A1  - Gessner, Andre
A1  - Kumke, Michael Uwe
T1  - The effect of humic acid on the formation and solubility of secondary solid phases (Nd(OH)CO3 and Sm(OH)CO3)
JF  - Radiochimica acta : international journal for chemical aspects of nuclear science and technology
N2  - The formation of secondary Ln(III) solid phases (e.g. Nd(OH)CO3 and Sm(OH)CO3) has been studied as a function of the humic acid (HA) concentration in 0.1 M NaClO4 aqueous solution and their solubility has been investigated in the neutral pH range (6.5-8) under normal atmospheric conditions. Nd(III) and Sm(III) were selected as analogues for trivalent lanthanide and actinide ions. The solid phases under investigation have been prepared by alkaline precipitation and characterized by TGA, ATR-FTIR, XRD, TRLFS, DR-UV-Vis and Raman spectroscopy, and solubility measurements. The spectroscopic data obtained indicate that Nd(OH)CO3 and Sm(OH)CO3 are stable and remain the solubility limiting solid phases even in the presence of increased HA concentration (0.5 g/L) in solution. Upon base addition in the Ln(III)-HA system decomplexation of the previously formed Ln(III)-humate complexes and precipitation of two distinct phases occurs, the inorganic (Ln(OH)CO3) and the organic phase (HA), which is adsorbed on the particle surface of the former. Nevertheless, HA affects the particle size of the solid phases. Increasing HA concentration results in decreasing crystallite size of the Nd(OH)CO3 and increasing crystallite size of the Sm(OH)CO3 solid phase, and affects inversely the solubility of the solid phases. However, this impact on the solid phase properties is expected to be of minor relevance regarding the chemical behavior and migration of trivalent lanthanides and actinides in the geosphere.
KW  - Lanthanide ions
KW  - Humic acid
KW  - Solid phase
KW  - Solubility
KW  - Raman
KW  - TRLFS
KW  - DR-UV-Vis
Y1  - 2011
U6  - https://doi.org/10.1524/ract.2011.1812
SN  - 0033-8230
VL  - 99
IS  - 4
SP  - 217
EP  - 223
PB  - De Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Antoniou, Stella
A1  - Pashalidis, Ioannis
A1  - Gessner, Andre
A1  - Kumke, Michael Uwe
T1  - Spectroscopic investigations on the effect of humic acid on the formation and solubility of secondary solid phases of Ln(2)(CO3)(3)
JF  - Journal of rare earths
N2  - The formation of secondary Ln(III) solid phases (e.g., Nd-2(CO3)(3) and Sm-2(CO3)(3)) was studied as a function of the humic acid concentration in 0.1 mol/L NaClO4 aqueous solution in the neutral pH range (5-6.5). The solid phases under investigation were prepared by alkaline precipitation under 100% CO2 atmosphere and characterized by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), time-resolved laser fluorescence spectroscopy (TRLFS), diffuse reflectance ultraviolet-visible (DR-UV-Vis), Raman spectroscopy, and solubility measurements. The spectroscopic data obtained indicated that Nd-2(CO3)(3) and Sm-2(CO3)(3) were stable and remained the solubility limiting solid phases even in the presence of increased humic acid concentration (0.5 g/L) in solution. Upon base addition in the Ln(III)-HA system, decomplexation of the previously formed Ln(III)-humate complexes and precipitation of two distinct phases occurred, the inorganic (Ln(2)(CO3)(3)) and the organic phase (HA), which was adsorbed on the particle surface of the former. Nevertheless, humic acid affected the particle size of the solid phases. Increasing humic acid concentration resulted in decreasing crystallite size of the Nd-2(CO3)(3) and increasing crystallite size of the Sm-2(CO3)(3) solid phase, and affected inversely the solubility of the solid phases. However, this impact on the solid phase properties was expected to be of minor relevance regarding the chemical behavior and migration of trivalent lanthanides and actinides in the geosphere.
KW  - lanthanide ions
KW  - humic acid
KW  - solid phase
KW  - solubility
KW  - Raman
KW  - TRLFS
KW  - DR-UV-Vis
KW  - rare earths
Y1  - 2011
U6  - https://doi.org/10.1016/S1002-0721(10)60490-5
SN  - 1002-0721
VL  - 29
IS  - 6
SP  - 516
EP  - 521
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Apel, Jens K.
A1  - Revie, Gavin F.
A1  - Cangelosi, Angelo
A1  - Ellis, Rob
A1  - Goslin, Jeremy
A1  - Fischer, Martin H.
T1  - Attention deployment during memorizing and executing complex instructions
JF  - Experimental brain research
N2  - We investigated the mental rehearsal of complex action instructions by recording spontaneous eye movements of healthy adults as they looked at objects on a monitor. Participants heard consecutive instructions, each of the form "move [object] to [location]''. Instructions were only to be executed after a go signal, by manipulating all objects successively with a mouse. Participants re-inspected previously mentioned objects already while listening to further instructions. This rehearsal behavior broke down after 4 instructions, coincident with participants' instruction span, as determined from subsequent execution accuracy. These results suggest that spontaneous eye movements while listening to instructions predict their successful execution.
KW  - Assembly task
KW  - Eye movements
KW  - Overt attention
KW  - Rehearsal
KW  - Sequential instruction
KW  - Working memory
Y1  - 2011
U6  - https://doi.org/10.1007/s00221-011-2827-4
SN  - 0014-4819
VL  - 214
IS  - 2
SP  - 249
EP  - 259
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Arbeiter, Susanne
A1  - Tegetmeyer, Cosima
T1  - Home range and habitat use by aquatic warblers acrocephalus paludicola on their wintering grounds in Northwestern Senegal
JF  - Acta ornithologica
N2  - The Aquatic Warbler Acrocephalus paludicola was once a common breeding bird in mesotrophic fen mires all over Central and Western Europe. In the last century large parts of its habitat have been destroyed by wetland drainage and agricultural intensification. Besides protecting the remaining breeding habitats, it is of great importance to preserve suitable migration stopover habitats and wintering grounds to avert the extinction of the species.
 We determined home-range size and the use of vegetation associations of Aquatic Warblers on the wintering grounds in a flooded plain north of the Djoudj National Park in Senegal. Individual birds (11) were caught in mist nets and equipped with radio transmitters. Locations were assessed by radiotelemetry and a compositional analysis was conducted to determine which vegetation types were preferred within home ranges.
 Similar to their behaviour on the breeding grounds, the Aquatic Warblers showed no territorial behaviour in their winter quarters. They used home ranges that averaged 4 ha in size, which they shared with conspecifics and other warblers. The home ranges overlapped 54% on average, with a maximum of 90% in an area used by four individuals. The vegetation structure of the wintering habitat is similar to breeding grounds and stopover sites of the species. Preferential vegetation had 80% to 100% cover and consisted of 60 to 90 cm high stands of Oryza longistaminata, Scirpus maritimus or Eleocharis mutata. Most birds stayed more often near the edge of open water, probably for foraging. A constant inundation seems essential, because Aquatic Warblers never occurred in desiccated parts of the study site.
KW  - Acrocephalus paludicola
KW  - Djoudj National Park
KW  - radio telemetry
KW  - transsaharan migrant
KW  - vegetation structure
Y1  - 2011
U6  - https://doi.org/10.3161/000164511X625883
SN  - 0001-6454
VL  - 46
IS  - 2
SP  - 117
EP  - 126
PB  - Museum and Institute of Zoology, Polish Academy of Sciences
CY  - Warsaw
ER  - 
TY  - JOUR
A1  - Arhammar, C.
A1  - Pietzsch, Annette
A1  - Bock, Nicolas
A1  - Holmstroem, Erik
A1  - Araujo, C. Moyses
A1  - Grasjo, Johan
A1  - Zhao, Shuxi
A1  - Green, Sara
A1  - Peery, T.
A1  - Hennies, Franz
A1  - Amerioun, Shahrad
A1  - Föhlisch, Alexander
A1  - Schlappa, Justine
A1  - Schmitt, Thorsten
A1  - Strocov, Vladimir N.
A1  - Niklasson, Gunnar A.
A1  - Wallace, Duane C.
A1  - Rubensson, Jan-Erik
A1  - Johansson, Borje
A1  - Ahuja, Rajeev C.
T1  - Unveiling the complex electronic structure of amorphous metal oxides
JF  - Proceedings of the National Academy of Sciences of the United States of America
N2  - Amorphous materials represent a large and important emerging area of material's science. Amorphous oxides are key technological oxides in applications such as a gate dielectric in Complementary metal-oxide semiconductor devices and in Silicon-Oxide-Nitride-Oxide-Silicon and TANOS (TaN-Al2O3-Si3N4-SiO2-Silicon) flash memories. These technologies are required for the high packing density of today's integrated circuits. Therefore the investigation of defect states in these structures is crucial. In this work we present X-ray synchrotron measurements, with an energy resolution which is about 5-10 times higher than is attainable with standard spectrometers, of amorphous alumina. We demonstrate that our experimental results are in agreement with calculated spectra of amorphous alumina which we have generated by stochastic quenching. This first principles method, which we have recently developed, is found to be superior to molecular dynamics in simulating the rapid gas to solid transition that takes place as this material is deposited for thin film applications. We detect and analyze in detail states in the band gap that originate from oxygen pairs. Similar states were previously found in amorphous alumina by other spectroscopic methods and were assigned to oxygen vacancies claimed to act mutually as electron and hole traps. The oxygen pairs which we probe in this work act as hole traps only and will influence the information retention in electronic devices. In amorphous silica oxygen pairs have already been found, thus they may be a feature which is characteristic also of other amorphous metal oxides.
KW  - stochastic quench
KW  - X-ray absorption spectroscopy
KW  - ab initio
KW  - coating
Y1  - 2011
U6  - https://doi.org/10.1073/pnas.1019698108
SN  - 0027-8424
VL  - 108
IS  - 16
SP  - 6355
EP  - 6360
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Arnold, Anne
A1  - Nikoloski, Zoran
T1  - A quantitative comparison of Calvin-Benson cycle models
JF  - Trends in plant science
N2  - The Calvin-Benson cycle (CBC) provides the precursors for biomass synthesis necessary for plant growth. The dynamic behavior and yield of the CBC depend on the environmental conditions and regulation of the cellular state. Accurate quantitative models hold the promise of identifying the key determinants of the tightly regulated CBC function and their effects on the responses in future climates. We provide an integrative analysis of the largest compendium of existing models for photosynthetic processes. Based on the proposed ranking, our framework facilitates the discovery of best-performing models with regard to metabolomics data and of candidates for metabolic engineering.
Y1  - 2011
U6  - https://doi.org/10.1016/j.tplants.2011.09.004
SN  - 1360-1385
VL  - 16
IS  - 12
SP  - 676
EP  - 683
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Arrighi, Pablo
A1  - Nesme, Vincent
A1  - Werner, Reinhard F.
T1  - One-Dimensional quantum cellular automata
JF  - International journal of unconventional computing : non-classical computation and cellular automata
N2  - We define and study quantum cellular automata (QCA). We show that they are reversible and that the neighborhood of the inverse is the opposite of the neighborhood. We also show that QCA always admit, modulo shifts, a two-layered block representation. Note that the same two-layered block representation result applies also over infinite configurations, as was previously shown for one-dimensional systems in the more elaborate formalism of operators algebras [18]. Here the proof is simpler and self-contained, moreover we discuss a counterexample QCA in higher dimensions.
KW  - cellular automata
KW  - quantum
KW  - neighborhood
KW  - block representation
Y1  - 2011
SN  - 1548-7199
VL  - 7
IS  - 4
SP  - 223
EP  - 244
PB  - Old City Publishing Science
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Arvidsson, Samuel Janne
A1  - Perez-Rodriguez, Paulino
A1  - Müller-Röber, Bernd
T1  - A growth phenotyping pipeline for Arabidopsis thaliana integrating image analysis and rosette area modeling for robust quantification of genotype effects
JF  - New phytologist : international journal of plant science
N2  - To gain a deeper understanding of the mechanisms behind biomass accumulation, it is important to study plant growth behavior. Manually phenotyping large sets of plants requires important human resources and expertise and is typically not feasible for detection of weak growth phenotypes. Here, we established an automated growth phenotyping pipeline for Arabidopsis thaliana to aid researchers in comparing growth behaviors of different genotypes.
 The analysis pipeline includes automated image analysis of two-dimensional digital plant images and evaluation of manually annotated information of growth stages. It employs linear mixed-effects models to quantify genotype effects on total rosette area and relative leaf growth rate (RLGR) and ANOVAs to quantify effects on developmental times.
 Using the system, a single researcher can phenotype up to 7000 plants d(-1). Technical variance is very low (typically < 2%). We show quantitative results for the growth-impaired starch-excessmutant sex4-3 and the growth-enhancedmutant grf9.
 We show that recordings of environmental and developmental variables reduce noise levels in the phenotyping datasets significantly and that careful examination of predictor variables (such as d after sowing or germination) is crucial to avoid exaggerations of recorded phenotypes and thus biased conclusions.
KW  - development
KW  - growth
KW  - leaf area
KW  - modeling
KW  - phenotyping
Y1  - 2011
U6  - https://doi.org/10.1111/j.1469-8137.2011.03756.x
SN  - 0028-646X
VL  - 191
IS  - 3
SP  - 895
EP  - 907
PB  - Wiley-Blackwell
CY  - Malden
ER  - 
TY  - JOUR
A1  - Ast, Sandra
A1  - Müller, Holger
A1  - Flehr, Roman
A1  - Klamroth, Tillmann
A1  - Walz, Bernd
A1  - Holdt, Hans-Jürgen
T1  - High Na+ and K+-induced fluorescence enhancement of a pi-conjugated phenylaza-18-crown-6-triazol-substituted coumarin fluoroionophore
JF  - Chemical communications
N2  - The new pi-conjugated 1,2,3-triazol-1,4-diyl fluoroionophore 1 generated via Cu(I) catalyzed [3 + 2] cycloaddition shows high fluorescence enhancement factors (FEF) in the presence of Na+ (FEF = 58) and K+ (FEF = 27) in MeCN and high selectivity towards K+ under simulated physiological conditions (160 mM K+ or Na+, respectively) with a FEF of 2.5 for K+.
Y1  - 2011
U6  - https://doi.org/10.1039/c0cc04370b
SN  - 1359-7345
VL  - 47
IS  - 16
SP  - 4685
EP  - 4687
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - THES
A1  - Athikomrattanakul, Umporn
T1  - Development and characterization of molecularly imprinted polymers as binding elements against nitrofurantoin
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - THES
A1  - Avila, Gastón
T1  - Asymptotic staticity and tensor decompositions with fast decay conditions
T1  - Asymptotisch statische Anfangsdaten und Tensor-Zerlegungen mit starken Abfallbedingungen
N2  - Corvino, Corvino and Schoen, Chruściel and Delay have shown the existence of a large class of asymptotically flat vacuum initial data for Einstein's field equations which are static or stationary in a neighborhood of space-like infinity, yet quite general in the interior. The proof relies on some abstract, non-constructive arguments which makes it difficult to calculate such data numerically by using similar arguments. A quasilinear elliptic system of equations is presented of which we expect that it can be used to construct vacuum initial data which are asymptotically flat, time-reflection symmetric, and asymptotic to static data up to a prescribed order at space-like infinity. A perturbation argument is used to show the existence of solutions. It is valid when the order at which the solutions approach staticity is restricted to a certain range. Difficulties appear when trying to improve this result to show the existence of solutions that are asymptotically static at higher order. The problems arise from the lack of surjectivity of a certain operator. Some tensor decompositions in asymptotically flat manifolds exhibit some of the difficulties encountered above. The Helmholtz decomposition, which plays a role in the preparation of initial data for the Maxwell equations, is discussed as a model problem. A method to circumvent the difficulties that arise when fast decay rates are required is discussed. This is done in a way that opens the possibility to perform numerical computations. The insights from the analysis of the Helmholtz decomposition are applied to the York decomposition, which is related to that part of the quasilinear system which gives rise to the difficulties. For this decomposition analogous results are obtained. It turns out, however, that in this case the presence of symmetries of the underlying metric leads to certain complications. The question, whether the results obtained so far can be used again to show by a perturbation argument the existence of vacuum initial data which approach static solutions at infinity at any given order, thus remains open. The answer requires further analysis and perhaps new methods.
N2  - Corvino, Corvino und Schoen als auch Chruściel und Delay haben die Existenz einer grossen Klasse asymptotisch flacher Anfangsdaten für Einsteins Vakuumfeldgleichungen gezeigt, die in einer Umgebung des raumartig Unendlichen statisch oder stationär aber im Inneren der Anfangshyperfläche sehr allgemein sind. Der Beweis beruht zum Teil auf abstrakten, nicht konstruktiven Argumenten, die Schwierigkeiten bereiten, wenn derartige Daten numerisch berechnet werden sollen. In der Arbeit wird ein quasilineares elliptisches Gleichungssystem vorgestellt, von dem wir annehmen, dass es geeignet ist, asymptotisch flache Vakuumanfangsdaten zu berechnen, die zeitreflektionssymmetrisch sind und im raumartig Unendlichen in einer vorgeschriebenen Ordnung asymptotisch zu statischen Daten sind. Mit einem Störungsargument wird ein Existenzsatz bewiesen, der gilt, solange die Ordnung, in welcher die Lösungen asymptotisch statische Lösungen approximieren, in einem gewissen eingeschränkten Bereich liegt. Versucht man, den Gültigkeitsbereich des Satzes zu erweitern, treten Schwierigkeiten auf. Diese hängen damit zusammen, dass ein gewisser Operator nicht mehr surjektiv ist. In einigen Tensorzerlegungen auf asymptotisch flachen Räumen treten ähnliche Probleme auf, wie die oben erwähnten. Die Helmholtzzerlegung, die bei der Bereitstellung von Anfangsdaten für die Maxwellgleichungen eine Rolle spielt, wird als ein Modellfall diskutiert. Es wird eine Methode angegeben, die es erlaubt, die Schwierigkeiten zu umgehen, die auftreten, wenn ein schnelles Abfallverhalten des gesuchten Vektorfeldes im raumartig Unendlichen gefordert wird. Diese Methode gestattet es, solche Felder auch numerisch zu berechnen. Die Einsichten aus der Analyse der Helmholtzzerlegung werden dann auf die Yorkzerlegung angewandt, die in den Teil des quasilinearen Systems eingeht, der Anlass zu den genannten Schwierigkeiten gibt. Für diese Zerlegung ergeben sich analoge Resultate. Es treten allerdings Schwierigkeiten auf, wenn die zu Grunde liegende Metrik Symmetrien aufweist. Die Frage, ob die Ergebnisse, die soweit erhalten wurden, in einem Störungsargument verwendet werden können um die Existenz von Vakuumdaten zu zeigen, die im räumlich Unendlichen in jeder Ordnung statische Daten approximieren, bleibt daher offen. Die Antwort erfordert eine weitergehende Untersuchung und möglicherweise auch neue Methoden.
KW  - Einsteins Feldgleichungen
KW  - Zwangsgleichungen
KW  - Tensor-Zerlegungen
KW  - raumartige Unendliche
KW  - elliptisches Gleichungssystem
KW  - Einstein's field equations
KW  - constraint equations
KW  - tensor decompositions
KW  - space-like infinity
KW  - elliptic systems
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-54046
ER  - 
TY  - JOUR
A1  - Awad, Ahmed Mahmoud Hany Aly
A1  - Weidlich, Matthias
A1  - Weske, Mathias
T1  - Visually specifying compliance rules and explaining their violations for business processes
JF  - Journal of visual languages and computing
N2  - A business process is a set of steps designed to be executed in a certain order to achieve a business value. Such processes are often driven by and documented using process models. Nowadays, process models are also applied to drive process execution. Thus, correctness of business process models is a must. Much of the work has been devoted to check general, domain-independent correctness criteria, such as soundness. However, business processes must also adhere to and show compliance with various regulations and constraints, the so-called compliance requirements. These are domain-dependent requirements.
 In many situations, verifying compliance on a model level is of great value, since violations can be resolved in an early stage prior to execution. However, this calls for using formal verification techniques, e.g., model checking, that are too complex for business experts to apply. In this paper, we utilize a visual language. BPMN-Q to express compliance requirements visually in a way similar to that used by business experts to build process models. Still, using a pattern based approach, each BPMN-Qgraph has a formal temporal logic expression in computational tree logic (CTL). Moreover, the user is able to express constraints, i.e., compliance rules, regarding control flow and data flow aspects. In order to provide valuable feedback to a user in case of violations, we depend on temporal logic querying approaches as well as BPMN-Q to visually highlight paths in a process model whose execution causes violations.
KW  - Business process modeling
KW  - Compliance checking
KW  - Visual modeling
KW  - Anti-patterns
Y1  - 2011
U6  - https://doi.org/10.1016/j.jvlc.2010.11.002
SN  - 1045-926X
VL  - 22
IS  - 1
SP  - 30
EP  - 55
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Awad, Duha Jawad
A1  - Schilde, Uwe
A1  - Strauch, Peter
T1  - 4,4 '-Bis(tert-butyl)-2,2 '-bipyridinedichlorometal(II) - Synthesis, structure and EPR spectroscopy
JF  - Inorganica chimica acta : the international inorganic chemistry journal
N2  - Due to the better solubility of the 4,4'-substituted bipyridine ligand a series of 4,4'0-bis(tert-butyl)-2,2'-bipyridinedichlorometal(II) complexes, [M(tbbpy)Cl(2)], with M = Cu, Ni, Zn, Pd, Pt was synthesised and characterised. The blue copper complex 4,4'-bis(tert-butyl)-2,2'-bipyridinedichlorocopper(II) was isolated in two different polymorphic forms, as prisms 1 with a solvent inclusion and solvent-free as needles 2. Both structures were determined by X-ray structure analysis. They crystallise in the monoclinic space group P2(1)/c with four molecules in the unit cell, but with different unit cells and packing motifs. Whereas in the prisms 1, with the unit cell parameters a = 12.1613(12), b = 10.6363(7), c = 16.3074(15) angstrom, eta = 94.446(8)degrees, the packing is dominated by intra-and intermolecular hydrogen bonds, in the needles 2, with a = 7.738(1), b = 18. 333(2), c = 13.291(3) angstrom, beta = 97.512(15)degrees, only intramolecular hydrogen bonds appear and the complex molecules are arranged in columns which are stabilised by p-p-stacking interactions. In both complexes the copper has a tetrahedrally distorted coordination sphere. These copper complexes were also studied by EPR spectroscopy in solution, as frozen glass and diamagnetically diluted powder with the analogue [Pd(tbbpy)Cl(2)] as host lattice.
KW  - 4,4 '-Bis(tert-butyl)-2,2 '-bipyridine
KW  - X-ray structure
KW  - EPR
KW  - Copper(II)
KW  - Transition metals
Y1  - 2011
U6  - https://doi.org/10.1016/j.ica.2010.08.035
SN  - 0020-1693
VL  - 365
IS  - 1
SP  - 127
EP  - 132
PB  - Elsevier
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bagnich, Sergey A.
A1  - Unger, Th.
A1  - Jaiser, F.
A1  - Neher, Dieter
A1  - Thesen, M. W.
A1  - Krüger, H.
T1  - Efficient green electrophosphorescence based on ambipolar nonconjugated polymers evaluation of transport and emission properties
JF  - Journal of applied physics
N2  - New materials for polymer organic light-emitting diodes based on a polymer matrix doped with phosphorescent dyes are presented. The matrix system is based on a polystyrene backbone bearing either electron or hole transporting units at the 4-position of each repeat unit. Random copolymers and polymer blend systems of the homopolymers are prepared, both with 62 wt.% electron transporting and 38 wt.% hole transporting moieties. Adding a green electrophosphorescent dye to the polymer matrix leads to efficient electroluminescence with a maximum current efficiency of 35 cd/A and a maximum external quantum efficiency of up to 10%. The mobilities of electrons and holes in the dye-doped copolymer, as measured by transient electroluminescence, are around 5 x 10(-5) and 5 x 10(-6) cm(2)/Vs, respectively, while the blend of the two homopolymers exhibits slightly lower mobilities of both types of carriers. Despite the pronounced imbalance of charge transport, the device performance is almost entirely limited by the phosphorescence efficiency of the dye, implying balanced flow of holes and electrons into the active region. Also, devices made with either the copolymer or the blend yielded very similar device efficiencies, despite the noticeable difference in electron and hole mobility. It is proposed that electrons are efficiently blocked at the interlayer and that the so-formed space charge assists the balanced injection of holes.
Y1  - 2011
U6  - https://doi.org/10.1063/1.3618681
SN  - 0021-8979
SN  - 1089-7550
VL  - 110
IS  - 3
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Bakera, Marco
A1  - Margaria, Tiziana
A1  - Renner, Clemens D.
A1  - Steffen, Bernhard
T1  - Game-Based model checking for reliable autonomy in space
JF  - Journal of aerospace computing, information, and communication
N2  - Autonomy is an emerging paradigm for the design and implementation of managed services and systems. Self-managed aspects frequently concern the communication of systems with their environment. Self-management subsystems are critical, they should thus be designed and implemented as high-assurance components. Here, we propose to use GEAR, a game-based model checker for the full modal mu-calculus, and derived, more user-oriented logics, as a user friendly tool that can offer automatic proofs of critical properties of such systems. Designers and engineers can interactively investigate automatically generated winning strategies resulting from the games, this way exploring the connection between the property, the system, and the proof. The benefits of the approach are illustrated on a case study that concerns the ExoMars Rover.
Y1  - 2011
U6  - https://doi.org/10.2514/1.32013
SN  - 1940-3151
VL  - 8
IS  - 4
SP  - 100
EP  - 114
PB  - American Institute of Aeronautics and Astronautics
CY  - Reston
ER  - 
TY  - JOUR
A1  - Bakhshayesh, Ali Reza
A1  - Hänsch, Sylvana
A1  - Wyschkon, Anne
A1  - Rezai, Mohammad Javad
A1  - Esser, Günter
T1  - Neurofeedback in ADHD : a single-blind randomized controlled trial
N2  - Neurofeedback treatment has been demonstrated to reduce inattention, impulsivity and hyperactivity in children with attention deficit/hyperactivity disorder (ADHD). However, previous studies did not adequately control confounding variables or did not employ a randomized reinforcer-controlled design. This study addresses those methodological shortcomings by comparing the effects of the following two matched biofeedback training variants on the primary symptoms of ADHD: EEG neurofeedback (NF) aiming at theta/beta ratio reduction and EMG biofeedback (BF) aiming at forehead muscle relaxation. Thirty-five children with ADHD (26 boys, 9 girls; 6-14 years old) were randomly assigned to either the therapy group (NF; n = 18) or the control group (BF; n = 17). Treatment for both groups consisted of 30 sessions. Pre- and post-treatment assessment consisted of psychophysiological measures, behavioural rating scales completed by parents and teachers, as well as psychometric measures. Training effectively reduced theta/beta ratios and EMG levels in the NF and BF groups, respectively. Parents reported significant reductions in primary ADHD symptoms, and inattention improvements in the NF group were higher compared to the control intervention (BF, dcorr = -.94). NF training also improved attention and reaction times on the psychometric measures. The results indicate that NF effectively reduced inattention symptoms on parent rating scales and reaction time in neuropsychological tests. However, regarding hyperactivity and impulsivity symptoms, the results imply that non-specific factors, such as behavioural contingencies, self-efficacy, structured learning environment and feed-forward processes, may also contribute to the positive behavioural effects induced by neurofeedback training.
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Bakhshayesh, Ali Reza
A1  - Hänsch, Sylvana
A1  - Wyschkon, Anne
A1  - Rezai, Mohammad Javad
A1  - Esser, Günter
T1  - Neurofeedback in ADHD  a single-blind randomized controlled trial
JF  - European child and adolescent psychiatry : offical journal of the European Society for Child and Adolescent Psychiatry
N2  - Neurofeedback treatment has been demonstrated to reduce inattention, impulsivity and hyperactivity in children with attention deficit/hyperactivity disorder (ADHD). However, previous studies did not adequately control confounding variables or did not employ a randomized reinforcer-controlled design. This study addresses those methodological shortcomings by comparing the effects of the following two matched biofeedback training variants on the primary symptoms of ADHD: EEG neurofeedback (NF) aiming at theta/beta ratio reduction and EMG biofeedback (BF) aiming at forehead muscle relaxation. Thirty-five children with ADHD (26 boys, 9 girls; 6-14 years old) were randomly assigned to either the therapy group (NF; n = 18) or the control group (BF; n = 17). Treatment for both groups consisted of 30 sessions. Pre- and post-treatment assessment consisted of psychophysiological measures, behavioural rating scales completed by parents and teachers, as well as psychometric measures. Training effectively reduced theta/beta ratios and EMG levels in the NF and BF groups, respectively. Parents reported significant reductions in primary ADHD symptoms, and inattention improvements in the NF group were higher compared to the control intervention (BF, d(corr) = -.94). NF training also improved attention and reaction times on the psychometric measures. The results indicate that NF effectively reduced inattention symptoms on parent rating scales and reaction time in neuropsychological tests. However, regarding hyperactivity and impulsivity symptoms, the results imply that non-specific factors, such as behavioural contingencies, self-efficacy, structured learning environment and feed-forward processes, may also contribute to the positive behavioural effects induced by neurofeedback training.
KW  - Biofeedback
KW  - Neurofeedback
KW  - EMG biofeedback
KW  - ADHD
KW  - Single-blind
Y1  - 2011
U6  - https://doi.org/10.1007/s00787-011-0208-y
SN  - 1018-8827
VL  - 20
IS  - 9
SP  - 481
EP  - 491
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Balazadeh, Salma
A1  - Kwasniewski, Miroslaw
A1  - Caldana, Camila
A1  - Mehrnia, Mohammad
A1  - Zanor, Maria Ines
A1  - Xue, Gang-Ping
A1  - Müller-Röber, Bernd
T1  - ORS1, an H2O2-Responsive NAC Transcription Factor, Controls Senescence in Arabidopsis thaliana
JF  - Molecular plant
N2  - We report here that ORS1, a previously uncharacterized member of the NAC transcription factor family, controls leaf senescence in Arabidopsis thaliana. Overexpression of ORS1 accelerates senescence in transgenic plants, whereas its inhibition delays it. Genes acting downstream of ORS1 were identified by global expression analysis using transgenic plants producing dexamethasone-inducible ORS1-GR fusion protein. Of the 42 up-regulated genes, 30 (similar to 70%) were previously shown to be up-regulated during age-dependent senescence. We also observed that 32 (similar to 76%) of the ORS1-dependent genes were induced by long-term (4 d), but not short-term (6 h) salinity stress (150 mM NaCl). Furthermore, expression of 16 and 24 genes, respectively, was induced after 1 and 5 h of treatment with hydrogen peroxide (H2O2), a reactive oxygen species known to accumulate during salinity stress. ORS1 itself was found to be rapidly and strongly induced by H2O2 treatment in both leaves and roots. Using in vitro binding site selection, we determined the preferred binding motif of ORS1 and found it to be present in half of the ORS1-dependent genes. ORS1 is a paralog of ORE1/ANAC092/AtNAC2, a previously reported regulator of leaf senescence. Phylogenetic footprinting revealed evolutionary conservation of the ORS1 and ORE1 promoter sequences in different Brassicaceae species, indicating strong positive selection acting on both genes. We conclude that ORS1, similarly to ORE1, triggers expression of senescence-associated genes through a regulatory network that may involve cross-talk with salt- and H2O2-dependent signaling pathways.
KW  - NAC transcription factor
KW  - leaf senescence
KW  - gene expression
KW  - gene regulatory network
KW  - hydrogen peroxide
Y1  - 2011
U6  - https://doi.org/10.1093/mp/ssq080
SN  - 1674-2052
VL  - 4
IS  - 2
SP  - 346
EP  - 360
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Balcke, Gerd U.
A1  - Hahn, M.
A1  - Oswald, Sascha Eric
T1  - Nitrogen as an indicator of mass transfer during in-situ gas sparging
JF  - Journal of contaminant hydrology
N2  - Aiming at the stimulation of intrinsic microbial activity, pulses of pure oxygen or pressurized air were recurrently injected into groundwater polluted with chlorobenzene. To achieve well-controlled conditions and intensive sampling, a large, vertical underground tank was filled with the local unconfined sandy aquifer material. In the course of two individual gas injections, one using pure oxygen and one using pressurized air, the mass transfer of individual gas species between trapped gas phase and groundwater was studied. Field data on the dissolved gas composition in the groundwater were combined with a kinetic model on gas dissolution and transport in porous media. Phase mass transfer of individual gas components caused a temporary enrichment of nitrogen, and to a lower degree of methane, in trapped gas leading to the formation of excess dissolved nitrogen levels downgradient from the dissolving gas phase. By applying a novel gas sampling method for dissolved gases in groundwater it was shown that dissolved nitrogen can be used as a partitioning tracer to indicate complete gas dissolution in porous media.
KW  - Inter-phase mass transfer
KW  - Groundwater
KW  - Remediation
KW  - Gas sparging
KW  - Nitrogen
KW  - Methane
KW  - Kinetics
KW  - Bitterfeld
Y1  - 2011
U6  - https://doi.org/10.1016/j.jconhyd.2011.05.005
SN  - 0169-7722
VL  - 126
IS  - 1-2
SP  - 8
EP  - 18
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Balderjahn, Ingo
A1  - Oloko, Shamsey
T1  - On the Moral Value of Cause related Marketing
JF  - Marketing : ZFP
Y1  - 2011
SN  - 0344-1369
VL  - 33
IS  - 2
SP  - 159
EP  - 170
PB  - C. H. Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Ballato, Paolo
A1  - Uba, Cornelius Eji
A1  - Landgraf, Angela
A1  - Strecker, Manfred
A1  - Sudo, Masafumi
A1  - Stockli, Daniel F.
A1  - Friedrich, Anke M.
A1  - Tabatabaei, Saeid H.
T1  - Arabia-Eurasia continental collision insights from late Tertiary foreland-basin evolution in the Alborz Mountains, northern Iran
JF  - Geological Society of America bulletin
N2  - A poorly understood lag time of 15-20 m.y. exists between the initial Arabia-Eurasia continental collision in late Eocene to early Oligocene time and the acceleration of tectonic and sedimentary processes across the collision zone in the early to late Miocene. The late Eocene to Miocene-Pliocene clastic and shallow-marine sedimentary rocks of the Kond, Eyvanekey, and Semnan Basins in the Alborz Mountains (northern Iran) offer the possibility to track the evolution of this orogen in the framework of collision processes. A transition from volcaniclastic submarine deposits to shallow-marine evaporites and terrestrial sediments occurred shortly after 36 Ma in association with reversals in sediment provenance, strata tilting, and erosional unroofing. These events followed the termination of subduction arc magmatism and marked a changeover from an extensional to a contractional regime in response to initiation of continental collision with the subduction of stretched Arabian lithosphere. This early stage of collision produced topographic relief associated with shallow foreland basins, suggesting that shortening and tectonic loading occurred at low rates. Starting from the early Miocene (17.5 Ma), flexural subsidence in response to foreland basin initiation occurred. Fast sediment accumulation rates and erosional unroofing trends point to acceleration of shortening by the early Miocene. We suggest that the lag time between the initiation of continental collision (36 Ma) and the acceleration of regional deformation (20-17.5 Ma) reflects a two-stage collision process, involving the "soft" collision of stretched lithosphere at first and "hard" collision following the arrival of unstretched Arabian continental litho sphere in the subduction zone.
Y1  - 2011
U6  - https://doi.org/10.1130/B30091.1
SN  - 0016-7606
VL  - 123
IS  - 1-2
SP  - 106
EP  - 131
PB  - American Institute of Physics
CY  - Boulder
ER  - 
TY  - JOUR
A1  - Banks, Jo Ann
A1  - Nishiyama, Tomoaki
A1  - Hasebe, Mitsuyasu
A1  - Bowman, John L.
A1  - Gribskov, Michael
A1  - dePamphilis, Claude
A1  - Albert, Victor A.
A1  - Aono, Naoki
A1  - Aoyama, Tsuyoshi
A1  - Ambrose, Barbara A.
A1  - Ashton, Neil W.
A1  - Axtell, Michael J.
A1  - Barker, Elizabeth
A1  - Barker, Michael S.
A1  - Bennetzen, Jeffrey L.
A1  - Bonawitz, Nicholas D.
A1  - Chapple, Clint
A1  - Cheng, Chaoyang
A1  - Correa, Luiz Gustavo Guedes
A1  - Dacre, Michael
A1  - DeBarry, Jeremy
A1  - Dreyer, Ingo
A1  - Elias, Marek
A1  - Engstrom, Eric M.
A1  - Estelle, Mark
A1  - Feng, Liang
A1  - Finet, Cedric
A1  - Floyd, Sandra K.
A1  - Frommer, Wolf B.
A1  - Fujita, Tomomichi
A1  - Gramzow, Lydia
A1  - Gutensohn, Michael
A1  - Harholt, Jesper
A1  - Hattori, Mitsuru
A1  - Heyl, Alexander
A1  - Hirai, Tadayoshi
A1  - Hiwatashi, Yuji
A1  - Ishikawa, Masaki
A1  - Iwata, Mineko
A1  - Karol, Kenneth G.
A1  - Koehler, Barbara
A1  - Kolukisaoglu, Uener
A1  - Kubo, Minoru
A1  - Kurata, Tetsuya
A1  - Lalonde, Sylvie
A1  - Li, Kejie
A1  - Li, Ying
A1  - Litt, Amy
A1  - Lyons, Eric
A1  - Manning, Gerard
A1  - Maruyama, Takeshi
A1  - Michael, Todd P.
A1  - Mikami, Koji
A1  - Miyazaki, Saori
A1  - Morinaga, Shin-ichi
A1  - Murata, Takashi
A1  - Müller-Röber, Bernd
A1  - Nelson, David R.
A1  - Obara, Mari
A1  - Oguri, Yasuko
A1  - Olmstead, Richard G.
A1  - Onodera, Naoko
A1  - Petersen, Bent Larsen
A1  - Pils, Birgit
A1  - Prigge, Michael
A1  - Rensing, Stefan A.
A1  - Mauricio Riano-Pachon, Diego
A1  - Roberts, Alison W.
A1  - Sato, Yoshikatsu
A1  - Scheller, Henrik Vibe
A1  - Schulz, Burkhard
A1  - Schulz, Christian
A1  - Shakirov, Eugene V.
A1  - Shibagaki, Nakako
A1  - Shinohara, Naoki
A1  - Shippen, Dorothy E.
A1  - Sorensen, Iben
A1  - Sotooka, Ryo
A1  - Sugimoto, Nagisa
A1  - Sugita, Mamoru
A1  - Sumikawa, Naomi
A1  - Tanurdzic, Milos
A1  - Theissen, Guenter
A1  - Ulvskov, Peter
A1  - Wakazuki, Sachiko
A1  - Weng, Jing-Ke
A1  - Willats, William W. G. T.
A1  - Wipf, Daniel
A1  - Wolf, Paul G.
A1  - Yang, Lixing
A1  - Zimmer, Andreas D.
A1  - Zhu, Qihui
A1  - Mitros, Therese
A1  - Hellsten, Uffe
A1  - Loque, Dominique
A1  - Otillar, Robert
A1  - Salamov, Asaf
A1  - Schmutz, Jeremy
A1  - Shapiro, Harris
A1  - Lindquist, Erika
A1  - Lucas, Susan
A1  - Rokhsar, Daniel
A1  - Grigoriev, Igor V.
T1  - The selaginella genome identifies genetic changes associated with the evolution of vascular plants
JF  - Science
N2  - Vascular plants appeared similar to 410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) and the lycophytes. We report here the genome sequence of the lycophyte Selaginella moellendorffii (Selaginella), the first nonseed vascular plant genome reported. By comparing gene content in evolutionarily diverse taxa, we found that the transition from a gametophyte- to a sporophyte-dominated life cycle required far fewer new genes than the transition from a nonseed vascular to a flowering plant, whereas secondary metabolic genes expanded extensively and in parallel in the lycophyte and angiosperm lineages. Selaginella differs in posttranscriptional gene regulation, including small RNA regulation of repetitive elements, an absence of the trans-acting small interfering RNA pathway, and extensive RNA editing of organellar genes.
Y1  - 2011
U6  - https://doi.org/10.1126/science.1203810
SN  - 0036-8075
VL  - 332
IS  - 6032
SP  - 960
EP  - 963
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Baraldi, Luca
T1  - Immobile Tremor
BT  - The Immobility of the Ghetto and the Human Vitality
JF  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V.
N2  - The threshold between the XVth and the XVIth Century represents a historical period during which, both for Christians and for Jews, the geopolitical sceneries and the interior horizons radically change. The modified reality provokes new forms of expectation and the need of new historical interpretations. Ferrara, within this scenery, can be considered, as other Italian cases, as a paradigmatic example, a narrow space where phenomena of spiritual and cultural Jewish rebirth can take shape. The permeability between Christian artistic and cultural world and Jewish intellectual production determines a prosperous context, further strengthened by the introduction of Jewish typography and by a growing claim and restoration of social elective dignity among the Jews of the Este Duchy. After the transfer of the capital city from Ferrara to Modena, the indirect effects of this intellectual resurgence are deeply transformed on a social level, and allows us to catch the persistence of important forms of communication between Christians and Jews in everyday life. The introduction of the Inquisition provides us, through the production of the judicial archive, with the most important instrument to understand social dynamics, which allows us to comprehend a new potential interpretation key for the reality of the ghetto and the choice of its erection. The urban division is nothing else but a new attempt to separate the invisible spaces of the thought. The effective efficacy of the physical separation shows several weak points, which persist during the entire life of the ghetto, since 1638 until 1789.
N2  - Die Schwelle zwischen dem 15. und 16. Jahrhundert stellt eine historische Periode dar, in der sich die geopolitische Landschaft und das innere Blickfeld sowohl für Christen als auch für Juden radikal änderten. Die veränderten Gegebenheiten lösten andere Erwartungen und das Bedürfnis nach neuen historischen Interpretationen aus. In diesem Kontext kann Ferrara, wie auch andere italienische Städte, als ein paradigmatisches Beispiel angesehen werden, als ein begrenzter Raum, in dem das spirituelle und kulturelle Wiederaufleben innerhalb der jüdischen Gesellschaft Gestalt annehmen konnte. Die Durchlässigkeit zwischen der künstlerischen und kulturellen christlichen Welt und jüdisch-intellektuellen Erzeugnissen bedingte ein gedeihendes Umfeld, das zudem durch die Einführung einer jüdischen Typographie und durch wachsende Ansprüche der Juden im Herzogtum der Este bestärkt wurde. Die indirekten Einflüsse auf dieses intellektuelle Wiederaufleben wirkten sich nach der Verlegung der Hauptstadt von Ferrara nach Modena tiefgreifend auf einer sozialen Ebene aus. Sie erlauben uns, das Fortdauern wichtiger Kommunikationsmuster zwischen Christen und Juden im Alltag zu erfassen. Das Einsetzen der Inquisition bietet uns mittels juristischer Archive die wichtigsten Instrumente, um soziale Dynamiken zu verstehen. Diese erlauben uns, neue denkbare Interpretationen als Schlüssel für die Gegebenheiten im Ghetto und für die Gründe seiner Errichtung in Betracht zu ziehen. Die städtische Trennungslinie ist nichts anderes als ein weiterer Versuch, die unsichtbaren Räume der Gedankenwelten voneinander abzugrenzen. Die nachhaltige Wirksamkeit der räumlichen Trennung weist einige Schwachpunkte auf, die während der gesamten Existenzphase des Ghettos von 1638 bis 1789 bestehen blieben.
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-53255
SN  - 1614-6492
SN  - 1862-7684
IS  - 17
SP  - 71
EP  - 95
ER  - 
TY  - JOUR
A1  - Baranac-Stojanovic, Marija
A1  - Keinpeter, Erich
T1  - Quantification of the aromaticity of 2-Alkylidenethiazolines subjected to push-pull activity
JF  - The journal of organic chemistry
N2  - Through-space NMR shieldings (TSNMRSs) of a series of 2-alkylidenethiazolines subjected to push-pull activity have been calculated by the GIAO method employing the nucleus-independent chemical shift (NICS) concept and visualized as iso-chemical-shielding surfaces (ICSSs). The ICSSs were applied to quantify and visualize the degree of aromaticity of the studied compounds, which has been shown to be in excellent correlation with the push-pull behavior, quantified by the quotient (pi*/pi) method. Dissection of the absolute magnetic shielding values into individual contributions of bonds and lone pairs by the natural chemical shielding-natural bond orbital (NCS-NBO) analysis has revealed unexpected details.
Y1  - 2011
U6  - https://doi.org/10.1021/jo200294f
SN  - 0022-3263
VL  - 76
IS  - 10
SP  - 3861
EP  - 3871
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - THES
A1  - Barbosa Pfannes, Eva Katharina
T1  - Probing the regulatory mechanisms of the actomyosin system in motile cells
T1  - Erforschung von Regulationsmechanismen des Aktomyosinsystems in bewegliche Zellen
N2  - Actin-based directional motility is important for embryonic development, wound healing, immune responses, and development of tissues. Actin and myosin are essential players in this process that can be subdivided into protrusion, adhesion, and traction. Protrusion is the forward movement of the membrane at the leading edge of the cell. Adhesion is required to enable movement along a substrate, and traction finally leads to the forward movement of the entire cell body, including its organelles. While actin polymerization is the main driving force in cell protrusions, myosin motors lead to the contraction of the cell body. The goal of this work was to study the regulatory mechanisms of the motile machinery by selecting a representative key player for each stage of the signaling process: the regulation of Arp2/3 activity by WASP (actin system), the role of cGMP in myosin II assembly (myosin system), and the influence of phosphoinositide signaling (upstream receptor pathway). The model organism chosen for this work was the social ameba Dictyostelium discoideum, due to the well-established knowledge of its cytoskeletal machinery, the easy handling, and the high motility of its vegetative and starvation developed cells. First, I focused on the dynamics of the actin cytoskeleton by modulating the activity of one of its key players, the Arp2/3 complex. This was achieved using the carbazole derivative Wiskostatin, an inhibitor of the Arp2/3 activator WASP. Cells treated with Wiskostatin adopted a round shape, with no of few pseudopodia. With the help of a microfluidic cell squeezer device, I could show that Wiskostatin treated cells display a reduced mechanical stability, comparable to cells treated with the actin disrupting agent Latrunculin A. Furthermore, the WASP inhibited cells adhere stronger to a surface and show a reduced motility and chemotactic performance. However, the overall F-actin content in the cells was not changed. Confocal microscopy and TIRF microscopy imaging showed that the cells maintained an intact actin cortex. Localized dynamic patches of increased actin polymerization were observed that, however, did not lead to membrane deformation. This indicated that the mechanisms of actin-driven force generation were impaired in Wiskostatin treated cells. It is concluded that in these cells, an altered architecture of the cortical network leads to a reduced overall stiffness of the cell, which is insufficient to support the force generation required for membrane deformation and pseudopod formation. Second, the role of cGMP in myosin II dynamics was investigated. Cyclic GMP is known to regulate the association of myosin II with the cytoskeleton. In Dictyostelium, intracellular cGMP levels increase when cells are exposed to chemoattractants, but also in response to osmotic stress. To study the influence of cyclic GMP on actin and myosin II dynamics, I used the laser-induced photoactivation of a DMACM-caged-Br-cGMP to locally release cGMP inside the cell. My results show that cGMP directly activates the myosin II machinery, but is also able to induce an actin response independently of cAMP receptor activation and signaling. The actin response was observed in both vegetative and developed cells. Possible explanations include cGMP-induced actin polymerization through VASP (vasodilator-stimulated phosphoprotein) or through binding of cGMP to cyclic nucleotide-dependent kinases. Finally, I investigated the role of phosphoinositide signaling using the Polyphosphoinositide-Binding Peptide (PBP10) that binds preferentially to PIP2. Phosphoinositides can recruit actin-binding proteins to defined subcellular sites and alter their activity. Neutrophils, as well as developed Dictyostelium cells produce PIP3 in the plasma membrane at their leading edge in response to an external chemotactic gradient. Although not essential for chemotaxis, phosphoinositides are proposed to act as an internal compass in the cell. When treated with the peptide PBP10, cells became round, with fewer or no pseudopods. PH-CRAC translocation to the membrane still occurs, even at low cAMP stimuli, but cell motility (random and directional) was reduced. My data revealed that the decrease in the pool of available PIP2 in the cell is sufficient to impair cell motility, but enough PIP2 remains so that PIP3 is formed in response to chemoattractant stimuli. My data thus highlights how sensitive cell motility and morphology are to changes in the phosphoinositide signaling. In summary, I have analyzed representative regulatory mechanisms that govern key parts of the motile machinery and characterized their impact on cellular properties including mechanical stability, adhesion and chemotaxis.
N2  - Das Ziel der Arbeit war es, die regulatorischen Mechanismen der Zellmotilität zu untersuchen. Dazu habe ich für jedes Stadium dieses Prozesses einen repräsentativen regulatorischen Schritt ausgewählt und genauer untersucht: Die Regelung des Arp2/3 Komplexes durch WASP (Aktinsystem), die Rolle von cGMP in der Myosin II-Regulation (Myosinsystem) und der Einfluss von Phosphoinositiden im intrazellulären Signalprozess (Rezeptor-Signalweg). Die soziale Amöbe Dictyostelium discoideum wurde als Modellorganismus für diese Arbeiten gewählt. Gründe für diese Wahl waren die bereits vorliegenden detaillierten Kenntnisse über das Zytoskelett dieser Zellen, ihre einfache Handhabbarkeit im Labor, und die hohe Motilität der Zellen im vegetativen und entwickelten Zustand. Als Erstes analysierte ich die Dynamik des Aktin-Zytoskeletts durch Modulation der Aktivität des Arp2/3-Komplexes. Dafür benutzte ich das Carbazol-Derivat Wiskostatin, ein Inhibitor des Arp2/3-Aktivators WASP. Zellen, die mit Wiskostatin behandelt wurden, zeigten eine runde Form mit wenigen oder keinen Pseudopodien. Mit Hilfe des mikrofluidischen cell squeezer device konnte ich zeigen, dass Wiskostatin-behandelte Zellen eine geringere mechanische Stabilität aufweisen, vergleichbar mit Zellen unter dem Einfluss des Aktin-depolymerisierenden Wirkstoffes Latrunculin A. Darüber hinaus zeigen Wiskostatin behandelten Zellen eine erhöhte Substratadhäsion und eine verringerte Motilität und chemotaktische Effizienz. Der F-Aktingehalt der Zelle insgesamt blieb jedoch unverändert. Konfokal- und TIRF-mikroskopische Aufnahmen zeigten, dass die Zellen einen intakten Aktinkortex aufweisen. Es konnten lokalisierte dynamische Regionen erhöhter Aktinpolymerisation beobachtet werden, die jedoch nicht zur Ausbildung von Membrandeformationen führten. Daraus kann man rückschließen, dass die Mechanismen der Krafterzeugung im Aktin-Zytoskelett in WASP-inhibierten Zellen beeinträchtigt sind. Vermutlich liegt in diesen Zellen eine veränderte Mikroarchitektur des kortikalen Netzwerks vor, die zu einer verminderten Steifigkeit der Zelle führt, so dass die zur Bildung von Pseudopodien erforderlichen Kräfte nicht entfaltet werden können. Als Zweites wurde die Rolle von cGMP in der Myosin II-Dynamik untersucht. Es ist bekannt, dass cGMP die Assoziation von Myosin II mit dem Zytoskelett reguliert. In Dictyostelium steigt die intrazelluläre Konzentration von cGMP in Gegenwart von chemoattraktiven Lockstoffen sowie in Antwort auf osmotischen Stress. Um den Einfluss von cGMP auf die Aktin und Myosin II -Dynamik zu untersuchen, benutzte ich laserinduzierte Photoaktivierung von DMACM-caged-Br-cGMP, um cGMP lokal innerhalb der Zelle freizusetzen. Meine Ergebnisse zeigten, dass intrazelluläres cGMP direkt zur Aktivierung von Myosin II führt, jedoch auch Aktinantworten unabhängig vom cAMP-Rezeptorsignalweg induzieren kann. Die Aktinreaktion wurde sowohl in vegetativen als auch in entwickelten Zellen beobachtet. Eine mögliche Erklärung könnte die cGMP-induzierte Aktinpolymerisation über VASP (vasodilator-stimulated phosphoprotein) sein oder über die Bindung von cGMP an Nukleotid-abhängige Proteinkinasen. Als dritten Punkt meiner Arbeit untersuchte ich die Rolle der Phosphoinositide mit Hilfe des Phosphoinositide-bindenden Proteins PBP10, das bevorzugt an PIP2 bindet. Phosphoinositiden können Aktin-bindende Proteine zu definierten subzellulären Orten rekrutieren und ihre Aktivität verändern. Sowohl Neutrophile als auch entwickelte Dictyostelium Zellen produzieren PIP3 in der Plasmamembran an ihrer leading edge in Antwort auf externe Gradienten chemischer Lockstoffe. Obwohl Zellen auch ohne PIP3 chemotaktisches Verhalten zeigen, werden Phosphoinositide im Allgemeinen mit dem inneren chemotaktischen Kompass der Zelle in Verbindung gebracht. Mit dem Peptid PBP10 behandelte Zellen nahmen eine runde Form an, mit wenigen oder keinen Pseudopodien. PH-CRAC -Translokation zur Membran konnte in PBP10-behandelten Zellen selbst bei geringen cAMP-Stimuli weiterhin beobachtet werden. Ungerichtete wie auch gerichtete Zellmotiliät waren jedoch beeinträchtigt. Meine Daten zeigen, dass die Abnahme des PIP2-Pools in der Zelle durch PBP10 ausreicht, um die Zellmotilität zu beeinträchtigen, dass jedoch genug PIP2 erhalten bleibt um in Folge einer Rezeptorstimulation PIP3 zu produzieren. Die Ergebnisse demonstrieren daher, wie empfindlich Zellmotilität und -morphologie gegenüber Modifikationen im Phosphoinositid-Signalweg sind. Zusammenfassend habe ich mehrere repräsentative Beispiele für regulatorische Mechanismen der Zellmotilität untersucht und deren Auswirkung auf Eigenschaften der Zelle wie mechanische Stabilität, Zelladhäsion und Chemotaxis charakterisiert.
KW  - Dictyostelium
KW  - Aktomyosin
KW  - Wiskostatin
KW  - cGMP
KW  - PBP10
KW  - Dictyostelium
KW  - actomyosin
KW  - Wiskostatin
KW  - cGMP
KW  - PBP10
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-57812
ER  - 
TY  - JOUR
A1  - Barcelo-Coblijn, Gwendolyn
A1  - Laura Martin, Maria
A1  - de Almeida, Rodrigo F. M.
A1  - Antonia Noguera-Salva, Maria
A1  - Marcilla-Etxenike, Amaia
A1  - Guardiola-Serrano, Francisca
A1  - Lueth, Anja
A1  - Kleuser, Burkhard
A1  - Halver, John E.
A1  - Escriba, Pablo V.
T1  - Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy
JF  - Proceedings of the National Academy of Sciences of the United States of America
N2  - The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor compound, has not yet been fully elucidated. Here, we show that human cancer cells have markedly lower levels of sphingomyelin (SM) than nontumor (MRC-5) cells. In this context, 2OHOA treatment strongly augments SM mass (4.6-fold), restoring the levels found in MRC-5 cells, while a loss of phosphatidylethanolamine and phosphatidylcholine is observed (57 and 30%, respectively). The increased SM mass was due to a rapid and highly specific activation of SM synthases (SMS). This effect appeared to be specific against cancer cells as it did not affect nontumor MRC-5 cells. Therefore, low SM levels are associated with the tumorigenic transformation that produces cancer cells. SM accumulation occurred at the plasma membrane and caused an increase in membrane global order and lipid raft packing in model membranes. These modifications would account for the observed alteration by 2OHOA in the localization of proteins involved in cell apoptosis (Fas receptor) or differentiation (Ras). Importantly, SMS inhibition by D609 diminished 2OHOA effect on cell cycle. Therefore, we propose that the regulation of SMS activity in tumor cells is a critical upstream event in 2OHOA antitumor mechanism, which also explains its specificity for cancer cells, its potency, and the lack of undesired side effects. Finally, the specific activation of SMS explains the ability of this compound to trigger cell cycle arrest, cell differentiation, and autophagy or apoptosis in cancer cells.
KW  - anticancer
KW  - membrane-lipid therapy
KW  - lung cancer
KW  - membrane lipids
Y1  - 2011
U6  - https://doi.org/10.1073/pnas.1115484108
SN  - 0027-8424
VL  - 108
IS  - 49
SP  - 19569
EP  - 19574
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Bartek, Brian
A1  - Lewis, Richard L.
A1  - Vasishth, Shravan
A1  - Smith, Mason R.
T1  - In Search of on-line locality effects in sentence comprehension
JF  - Journal of experimental psychology : Learning, memory, and cognition
N2  - Many comprehension theories assert that increasing the distance between elements participating in a linguistic relation (e.g., a verb and a noun phrase argument) increases the difficulty of establishing that relation during on-line comprehension. Such locality effects are expected to increase reading times and are thought to reveal properties and limitations of the short-term memory system that supports comprehension. Despite their theoretical importance and putative ubiquity, however, evidence for on-line locality effects is quite narrow linguistically and methodologically: It is restricted almost exclusively to self-paced reading of complex structures involving a particular class of syntactic relation. We present 4 experiments (2 self-paced reading and 2 eyetracking experiments) that demonstrate locality effects in the course of establishing subject-verb dependencies; locality effects are seen even in materials that can be read quickly and easily. These locality effects are observable in the earliest possible eye-movement measures and are of much shorter duration than previously reported effects. To account for the observed empirical patterns, we outline a processing model of the adaptive control of button pressing and eye movements. This model makes progress toward the goal of eliminating linking assumptions between memory constructs and empirical measures in favor of explicit theories of the coordinated control of motor responses and parsing.
KW  - locality effects
KW  - working memory
KW  - sentence processing
Y1  - 2011
U6  - https://doi.org/10.1037/a0024194
SN  - 0278-7393
VL  - 37
IS  - 5
SP  - 1178
EP  - 1198
PB  - American Psychological Association
CY  - Washington
ER  - 
TY  - JOUR
A1  - Barthold, Frauke Katrin
A1  - Tyralla, Christoph
A1  - Schneider, Katrin
A1  - Vache, Kellie B.
A1  - Frede, Hans-Georg
A1  - Breuer, Lutz
T1  - How many tracers do we need for end member mixing analysis (EMMA)? - a sensitivity analysis
JF  - Water resources research
N2  - End member mixing analysis (EMMA) is a commonly applied method to identify and quantify the dominant runoff producing sources of water. It employs tracers to determine the dimensionality of the hydrologic system. Many EMMA studies have been conducted using two to six tracers, with some of the main tracers being Ca, Na, Cl(-), water isotopes, and alkalinity. Few studies use larger tracer sets including minor trace elements such as Li, Rb, Sr, and Ba. None of the studies has addressed the question of the tracer set size and composition, despite the fact that these determine which and how many end members (EM) will be identified. We examine how tracer set size and composition affects the conceptual model that results from an EMMA. We developed an automatic procedure that conducts EMMA while iteratively changing tracer set size and composition. We used a set of 14 tracers and 9 EMs. The validity of the resulting conceptual models was investigated under the aspects of dimensionality, EM combinations, and contributions to stream water. From the 16,369 possibilities, 23 delivered plausible results. The resulting conceptual models are highly sensitive to the tracer set size and composition. The moderate reproducibility of EM contributions indicates a still missing EM. It also emphasizes that the major elements are not always the most useful tracers and that larger tracer sets have an enhanced capacity to avoid false conclusions about catchment functioning. The presented approach produces results that may not be apparent from the traditional approach and it is a first step to add the idea of statistical significance to the EMMA approach.
Y1  - 2011
U6  - https://doi.org/10.1029/2011WR010604
SN  - 0043-1397
VL  - 47
IS  - 7360
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Bartlett, Nate C. -M.
A1  - Jankunas, Justin
A1  - Goswami, Tapas
A1  - Zare, Richard N.
A1  - Bouakline, Foudhil
A1  - Althorpe, Stuart C.
T1  - Differential cross sections for H + D-2 -> HD(v '=2, j '=0,3,6,9) + D at center-of-mass collision energies of 1.25, 1.61, and 1.97 eV
JF  - Physical chemistry, chemical physics : a journal of European Chemical Societies
N2  - We have measured differential cross sections (DCSs) for the reaction H + D-2 -> HD- (v' = 2, j' = 0,3,6,9) + D at center-of-mass collision energies E-coll of 1.25, 1.61, and 1.97 eV using the photoloc technique. The DCSs show a strong dependence on the product rotational quantum number. For the HD(v' = 2, j' = 0) product, the DCS is bimodal but becomes oscillatory as the collision energy is increased. For the other product states, they are dominated by a single peak, which shifts from back to sideward scattering as j' increases, and they are in general less sensitive to changes in the collision energy. The experimental results are compared to quantum mechanical calculations and show good, but not fully quantitative agreement.
Y1  - 2011
U6  - https://doi.org/10.1039/c0cp02460k
SN  - 1463-9076
VL  - 13
IS  - 18
SP  - 8175
EP  - 8179
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Basler, Georg
A1  - Ebenhoeh, Oliver
A1  - Selbig, Joachim
A1  - Nikoloski, Zoran
T1  - Mass-balanced randomization of metabolic networks
JF  - Bioinformatics
N2  - Motivation: Network-centered studies in systems biology attempt to integrate the topological properties of biological networks with experimental data in order to make predictions and posit hypotheses. For any topology-based prediction, it is necessary to first assess the significance of the analyzed property in a biologically meaningful context. Therefore, devising network null models, carefully tailored to the topological and biochemical constraints imposed on the network, remains an important computational problem.
 Results: We first review the shortcomings of the existing generic sampling scheme-switch randomization-and explain its unsuitability for application to metabolic networks. We then devise a novel polynomial-time algorithm for randomizing metabolic networks under the (bio)chemical constraint of mass balance. The tractability of our method follows from the concept of mass equivalence classes, defined on the representation of compounds in the vector space over chemical elements. We finally demonstrate the uniformity of the proposed method on seven genome-scale metabolic networks, and empirically validate the theoretical findings. The proposed method allows a biologically meaningful estimation of significance for metabolic network properties.
Y1  - 2011
U6  - https://doi.org/10.1093/bioinformatics/btr145
SN  - 1367-4803
VL  - 27
IS  - 10
SP  - 1397
EP  - 1403
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Basler, Georg
A1  - Nikoloski, Zoran
T1  - JMassBalance - mass-balanced randomization and analysis of metabolic networks
JF  - Bioinformatics
N2  - Analysis of biological networks requires assessing the statistical significance of network-based predictions by using a realistic null model. However, the existing network null model, switch randomization, is unsuitable for metabolic networks, as it does not include physical constraints and generates unrealistic reactions. We present JMassBalance, a tool for mass-balanced randomization and analysis of metabolic networks. The tool allows efficient generation of large sets of randomized networks under the physical constraint of mass balance. In addition, various structural properties of the original and randomized networks can be calculated, facilitating the identification of the salient properties of metabolic networks with a biologically meaningful null model.
Y1  - 2011
U6  - https://doi.org/10.1093/bioinformatics/btr448
SN  - 1367-4803
VL  - 27
IS  - 19
SP  - 2761
EP  - 2762
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - THES
A1  - Bauer, Barbara
T1  - The relevance of species traits for predicting the dynamics of diverse plankton communities
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - THES
A1  - Baumgartner, Jens
T1  - Nucleation and Growth of Magnetite Nanoparticles under Biomimetric Conditions
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Baumgärtel, Hellmut
T1  - A Characteristic decay semigroup for the resonances of trace class perturbations with analyticity conditions of semibounded hamiltonians
JF  - International journal of theoretical physic
N2  - To asymptotic complete scattering systems {M(+) + V, M(+)} on H(+) := L(2)(R(+), K, d lambda), where M(+) is the multiplication operator on H(+) and V is a trace class operator with analyticity conditions, a decay semigroup is associated such that the spectrum of the generator of this semigroup coincides with the set of all resonances (poles of the analytic continuation of the scattering matrix into the lower half plane across the positive half line), i.e. the decay semigroup yields a "time-dependent" characterization of the resonances. As a counterpart a "spectral characterization" is mentioned which is due to the "eigenvalue-like" properties of resonances.
KW  - Resonances
KW  - Scattering theory
KW  - Lax-Phillips theory
KW  - Decay semigroups
Y1  - 2011
U6  - https://doi.org/10.1007/s10773-010-0533-9
SN  - 0020-7748
VL  - 50
IS  - 7
SP  - 2002
EP  - 2008
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Baur, Heiner
A1  - Hirschmüller, Anja
A1  - Müller, Steffen
A1  - Mayer, Frank
T1  - Neuromuscular activity of the peroneal muscle after foot orthoses therapy in runners
JF  - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine
N2  - BAUR, H., A. HIRSCHMULLER, S. MULLER, and F. MAYER. Neuromuscular Activity of the Peroneal Muscle after Foot Orthoses Therapy in Runners. Med. Sci. Sports Exerc., Vol. 43, No. 8, pp. 1500-1506, 2011. Purpose: Foot orthoses are a standard option to treat overuse injury. Biomechanical data providing mechanisms of foot orthoses' effectiveness are sparse. Stability of the ankle joint complex might be a key factor. The purpose was therefore to analyze neuromuscular activity of the musculus peroneus longus in runners with overuse injury symptoms treated with foot orthoses. Methods: A total of 99 male and female runners with overuse injury symptoms randomized in a control group (CO) and an orthoses group (OR) were analyzed on a treadmill at 3.3 m.s(-1) before and after an 8-wk foot orthoses intervention. Muscular activity of the musculus peroneus longus was measured and quantified in the time domain (initial onset of activation (T-ini), time of maximal activity (T-max), total time of activation (T-tot)) and amplitude domain (amplitude in preactivation (A(pre)), weight acceptance (A(wa)), push-off (A(po))). Results: Peroneal activity in the time domain did not differ initially between CO and OR, and no effect was observed after therapy (T-ini: CO = -0.88 +/- 0.09, OR = -0.88 +/- 0.08 / T-max: CO = 0.14 +/- 0.06, OR = 0.15 +/- 0.06 / T-tot: CO = 0.40 +/- 0.09, OR = 0.41 +/- 0.09; P > 0.05). In preactivation (Apre), muscle activity was higher in OR after intervention (CO = 0.97 +/- 0.32, 95% confidence interval = 0.90-1.05; OR = 1.18 +/- 0.43, 95% confidence interval = 1.08-1.28; P = 0.003). There was no group or intervention effect during stance (A(wa): CO = 2.33 +/- 0.66, OR = 2.33 +/- 0.74 / A(po): CO = 0.80 +/- 0.41, OR = 0.88 +/- 0.40; P > 0.05). Conclusions: Enhanced muscle activation of the musculus peroneus longus in preactivation suggests an altered preprogrammed activity, which might lead to better ankle stability providing a possible mode of action for foot orthoses therapy.
KW  - ANKLE JOINT
KW  - EMG
KW  - INSERT
KW  - INSOLE
KW  - JOINT STABILITY
KW  - OVERUSE INJURY
Y1  - 2011
U6  - https://doi.org/10.1249/MSS.0b013e31820c64ae
SN  - 0195-9131
VL  - 43
IS  - 8
SP  - 1500
EP  - 1506
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Baur, Heiner
A1  - Müller, Steffen
A1  - Hirschmüller, Anja
A1  - Cassel, Michael
A1  - Weber, Josefine
A1  - Mayer, Frank
T1  - Comparison in lower leg neuromuscular activity between runners with unilateral mid-portion Achilles tendinopathy and healthy individuals
JF  - Journal of electromyography and kinesiology
N2  - Neuromuscular control in functional situations and possible impairments due to Achilles tendinopathy are not well understood.
 Thirty controls (CO) and 30 runners with Achilles tendinopathy (AT) were tested on a treadmill at 3.33 m s(-1) (12 km h(-1)). Neuromuscular activity of the lower leg (tibialis anterior, peroneal, and gastrocnemius muscle) was measured by surface electromyography. Mean amplitude values (MAV) for the gait cycle phases preactivation, weight acceptance and push-off were calculated and normalised to the mean activity of the entire gait cycle.
 MAVs of the tibialis anterior did not differ between CO and AT in any gait cycle phase. The activation of the peroneal muscle was lower in AT in weight acceptance (p = 0.006), whereas no difference between CO and AT was found in preactivation (p = 0.71) and push-off (p = 0.83). Also, MAVs of the gastrocnemius muscle did not differ between AT and CO in preactivity (p = 0.71) but were reduced in AT during weight acceptance (p = 0.001) and push-off (p = 0.04).
 Achilles tendinopathy does not seem to alter pre-programmed neural control but might induce mechanical deficits of the lower extremity during weight bearing (joint stability). This should be addressed in the therapy process of AT.
KW  - Ankle joint
KW  - Electromyography
KW  - Overuse injury
KW  - Running gait
Y1  - 2011
U6  - https://doi.org/10.1016/j.jelekin.2010.11.010
SN  - 1050-6411
VL  - 21
IS  - 3
SP  - 499
EP  - 505
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Baushev, Anton N.
T1  - Principal properties of the velocity distribution of dark matter particles on the outskirts of the Solar system
JF  - Monthly notices of the Royal Astronomical Society
N2  - The velocity distribution of the dark matter particles on the outskirts of the Solar system remains unclear. We suggest to determine it using experimentally found properties of the oldest halo objects. Indeed, the oldest halo stars and globular clusters form a collisionless system, as well as dark matter particles do, and they evolved in the same gravitational field. If we accept this analogy, we can show that the velocity distribution of the dark matter particles should be highly anisotropic and have a sharp maximum near upsilon similar to 500 km s(-1). The distribution is totally different from the Maxwell one.
 We analyse the influence of the distribution function on the results of dark matter detection experiments. It is found that the direct detection signal should differ noticeably from the one calculated from the Maxwell distribution with <upsilon > similar or equal to 220 km s(-1), which is conventional for direct detection experiments (the ratio depends on the detector properties and typically falls within the range between 6 and 0.2). Moreover, the sharp distinction from the Maxwell distribution can be very essential to the observations of dark matter annihilation.
KW  - elementary particles
KW  - methods: analytical
KW  - dark matter
Y1  - 2011
U6  - https://doi.org/10.1111/j.1745-3933.2011.01125.x
SN  - 0035-8711
VL  - 417
IS  - 1
SP  - L83
EP  - L87
PB  - Wiley-Blackwell
CY  - Malden
ER  - 
TY  - JOUR
A1  - Becci, Irene
T1  - Trapped between in and out : the post-institutional liminality of ex-prisoners in East Berlin
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Becci, Irene
T1  - Religion's multiple locations in Prison : Germany, Italy, Swiss
Y1  - 2011
ER  - 
TY  - JOUR
A1  - Becken, Michael
A1  - Ritter, Oliver
A1  - Bedrosian, Paul A.
A1  - Weckmann, Ute
T1  - Correlation between deep fluids, tremor and creep along the central San Andreas fault
JF  - Nature : the international weekly journal of science
N2  - The seismicity pattern along the San Andreas fault near Parkfield and Cholame, California, varies distinctly over a length of only fifty kilometres. Within the brittle crust, the presence of frictionally weak minerals, fault-weakening high fluid pressures and chemical weakening are considered possible causes of an anomalously weak fault northwest of Parkfield(1-4). Non-volcanic tremor from lower-crustal and upper-mantle depths(5-7) is most pronounced about thirty kilometres southeast of Parkfield and is thought to be associated with high pore-fluid pressures at depth(8). Here we present geophysical evidence of fluids migrating into the creeping section of the San Andreas fault that seem to originate in the region of the uppermost mantle that also stimulates tremor, and evidence that along-strike variations in tremor activity and amplitude are related to strength variations in the lower crust and upper mantle. Interconnected fluids can explain a deep zone of anomalously low electrical resistivity that has been imaged by magnetotelluric data southwest of the Parkfield-Cholame segment. Near Cholame, where fluids seem to be trapped below a high-resistivity cap, tremor concentrates adjacent to the inferred fluids within a mechanically strong zone of high resistivity. By contrast, sub-vertical zones of low resistivity breach the entire crust near the drill hole of the San Andreas Fault Observatory at Depth, northwest of Parkfield, and imply pathways for deep fluids into the eastern fault block, coincident with a mechanically weak crust and the lower tremor amplitudes in the lower crust. Fluid influx to the fault system is consistent with hypotheses of fault-weakening high fluid pressures in the brittle crust.
Y1  - 2011
U6  - https://doi.org/10.1038/nature10609
SN  - 0028-0836
VL  - 480
IS  - 7375
SP  - 87
EP  - U248
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Belova, Valentina
A1  - Shchukin, Dmitry G.
A1  - Gorin, Dmitry A.
A1  - Kopyshev, Alexey
A1  - Moehwald, Helmuth
T1  - A new approach to nucleation of cavitation bubbles at chemically modified surfaces
JF  - Physical chemistry, chemical physics : a journal of European Chemical Societies
N2  - Cavitation at the solid surface normally begins with nucleation, in which defects or assembled molecules located at a liquid-solid interface act as nucleation centers and are actively involved in the evolution of cavitation bubbles. Here, we propose a simple approach to evaluate the behavior of cavitation bubbles formed under high intensity ultrasound (20 kHz, 51.3 W cm (2)) at solid surfaces, based on sonication of patterned substrates with a small roughness (less than 3 nm) and controllable surface energy. A mixture of octadecylphosphonic acid (ODTA) and octadecanethiol (ODT) was stamped on the Si wafer coated with different thicknesses of an aluminium layer (20-500 nm). We investigated the growth mechanism of cavitation bubble nuclei and the evolution of individual pits (defects) formed under sonication on the modified surface. A new activation behavior as a function of Al thickness, sonication time, ultrasonic power and temperature is reported. In this process cooperativity is introduced, as initially formed pits further reduce the energy to form bubbles. Furthermore, cavitation on the patterns is a controllable process, where up to 40-50 min of sonication time only the hydrophobic areas are active nucleation sites. This study provides a convincing proof of our theoretical approach on nucleation.
Y1  - 2011
U6  - https://doi.org/10.1039/c1cp20218a
SN  - 1463-9076
VL  - 13
IS  - 17
SP  - 8015
EP  - 8023
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Benmehdi, Sabah
A1  - Makarava, Natallia
A1  - Benhamidouche, N.
A1  - Holschneider, Matthias
T1  - Bayesian estimation of the self-similarity exponent of the Nile River fluctuation
JF  - Nonlinear processes in geophysics
N2  - The aim of this paper is to estimate the Hurst parameter of Fractional Gaussian Noise (FGN) using Bayesian inference. We propose an estimation technique that takes into account the full correlation structure of this process. Instead of using the integrated time series and then applying an estimator for its Hurst exponent, we propose to use the noise signal directly. As an application we analyze the time series of the Nile River, where we find a posterior distribution which is compatible with previous findings. In addition, our technique provides natural error bars for the Hurst exponent.
Y1  - 2011
U6  - https://doi.org/10.5194/npg-18-441-2011
SN  - 1023-5809
VL  - 18
IS  - 3
SP  - 441
EP  - 446
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - THES
A1  - Bennecke, Gudrun Elisabeth
T1  - Turning wind into power : effects of stakeholder networks on renewalbe energy governanace in India
T2  - European university studies : series XXXI political science
Y1  - 2011
SN  - 978-3-631-61570-6
SN  - 0721-3654
VL  - 23
PB  - Lang Peter GmbH Internationaler Verlag der Wissenschaften
CY  - Frankfurt
ER  - 
TY  - JOUR
A1  - Berenstein, Igal
A1  - Beta, Carsten
T1  - Flow-induced control of chemical turbulence
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistr
N2  - We report spatiotemporal chaos in the Oregonator model of the Belousov-Zhabotinsky reaction. Spatiotemporal chaos spontaneously develops in a regime, where the underlying local dynamics show stable limit cycle oscillations (diffusion-induced turbulence). We show that spatiotemporal chaos can be suppressed by a unidirectional flow in the system. With increasing flow velocity, we observe a transition scenario from spatiotemporal chaos via a regime of travelling waves to a stationary steady state. At large flow velocities, we recover the known regime of flow distributed oscillations.
KW  - chaos
KW  - chemical equilibrium
KW  - chemically reactive flow
KW  - reaction kinetics theory
KW  - spatiotemporal phenomena
KW  - turbulence
Y1  - 2011
U6  - https://doi.org/10.1063/1.3656248
SN  - 0021-9606
VL  - 135
IS  - 16
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - THES
A1  - Berg, John K.
T1  - Size-dependent wetting behavior of organic molecules on solid surfaces
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Berger, Alfons
A1  - Schmid, Stefan M.
A1  - Engi, Martin
A1  - Bousquet, Romain
A1  - Wiederkehr, Michael
T1  - Mechanisms of mass and heat transport during Barrovian metamorphism: A discussion based on field evidence from the Central Alps (Switzerland/northern Italy)
JF  - Tectonics
N2  - Tectonic and metamorphic data for the Central Alps (Switzerland/Italy) are used to discuss this classic example of a Barrovian metamorphic terrain, notably the evolution of its thermal structure in space and time. Available P-T-t data indicate variable contributions of advective and conductive heat transport during collision and subsequent cooling and exhumation. Some areas experienced a prolonged period of partial melting while other areas, at the same time, show but moderate heating. The Barrow-type metamorphic field gradient observed in the final orogen is the result of two distinct tectonic processes, with their related advective and conductive heat transport processes. The two tectonic processes are (1) accretion of material within a subduction channel related to decompression and emplacement of high-pressure units in the middle crust and (2) wedging and related nappe formation in the continental lower plate. The second process postdates the first one. Wedging and underthrusting of continental lower plate material produces heat input into lower crustal levels, and this process is responsible for predominantly conductive heat transport in the overlying units. The interacting processes lead to different maximum temperatures at different times, producing the final Barrovian metamorphic field gradient. The south experienced rapid cooling, whereas the north shows moderate cooling rates. This discrepancy principally reflects differences in the temperature distribution in the deeper crust prior to cooling. Differences in the local thermal gradient that prevailed before the cooling also determined the relationships between cooling rate and exhumation rate in the different areas. Citation: Berger, A., S. M. Schmid, M. Engi, R. Bousquet, and M. Wiederkehr (2011), Mechanisms of mass and heat transport during Barrovian metamorphism: A discussion based on field evidence from the Central Alps (Switzerland/northern Italy), Tectonics, 30, TC1007, doi:10.1029/2009TC002622.
Y1  - 2011
U6  - https://doi.org/10.1029/2009TC002622
SN  - 0278-7407
VL  - 30
IS  - 2
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - THES
A1  - Bergner, André
T1  - Synchronization in complex systems with multiple time scales
T1  - Synchronisation in komplexen Systemen mit mehreren Zeitskalen
N2  - In the present work synchronization phenomena in complex dynamical systems exhibiting multiple time scales have been analyzed. Multiple time scales can be active in different manners. Three different systems have been analyzed with different methods from data analysis. The first system studied is a large heterogenous network of bursting neurons, that is a system with two predominant time scales, the fast firing of action potentials (spikes) and the burst of repetitive spikes followed by a quiescent phase. This system has been integrated numerically and analyzed with methods based on recurrence in phase space. An interesting result are the different transitions to synchrony found in the two distinct time scales. Moreover, an anomalous synchronization effect can be observed in the fast time scale, i.e. there is range of the coupling strength where desynchronization occurs. The second system analyzed, numerically as well as experimentally, is a pair of coupled CO₂ lasers in a chaotic bursting regime. This system is interesting due to its similarity with epidemic models. We explain the bursts by different time scales generated from unstable periodic orbits embedded in the chaotic attractor and perform a synchronization analysis of these different orbits utilizing the continuous wavelet transform. We find a diverse route to synchrony of these different observed time scales. The last system studied is a small network motif of limit cycle oscillators. Precisely, we have studied a hub motif, which serves as elementary building block for scale-free networks, a type of network found in many real world applications. These hubs are of special importance for communication and information transfer in complex networks. Here, a detailed study on the mechanism of synchronization in oscillatory networks with a broad frequency distribution has been carried out. In particular, we find a remote synchronization of nodes in the network which are not directly coupled. We also explain the responsible mechanism and its limitations and constraints. Further we derive an analytic expression for it and show that information transmission in pure phase oscillators, such as the Kuramoto type, is limited. In addition to the numerical and analytic analysis an experiment consisting of electrical circuits has been designed. The obtained results confirm the former findings.
N2  - In der vorliegenden Arbeit wurden Synchronisationsphänomene in komplexen Systemen mit mehreren Zeitskalen untersucht. Es gibt mehrere Möglichkeiten wie diese verschiedenen Zeitskalen vorkommen können. Drei verschiedene Systeme, jedes mit einer anderen Art von zeitlicher Multiskalität, wurden mit unterschiedlichen Methoden der Datenanalyse untersucht. Das erste untersuchte System ist ein ausgedehntes heterogenes Netzwerk von Neuronen mit zwei dominanten Zeitskalen, zum einen die schnelle Folge von Aktionspotenzialen und zum anderen einer abwechselnden Folge von einer Phase von Aktionspotenzialen und einer Ruhephase. Dieses System wurde numerisch integriert und mit Methoden der Phasenraumrekurrenz untersucht. Ein interessantes Ergebnis ist der unterschiedliche Übergang zur Synchronisation der Neuronen auf den beiden verschiedenen Zeitskalen. Des weiteren kann auf der schnellen Zeitskala eine anomale Synchronisation beobachtet werden, d.h. es gibt einen Bereich der Kopplungsstärke in dem es zu einer Desynchronisation kommt. Als zweites wurde, sowohl numerisch als auch experimentell, ein System von gekoppelten CO₂ Lasern untersucht, welche in einem chaotischen bursting Modus arbeiten. Dieses System ist auch durch seine Äquivalenz zu Epidemiemodellen interessant. Wir erklären die Bursts durch unterschiedliche Zeitskalen, welche durch in den chaotischen Attraktor eingebettete instabile periodische Orbits generiert werden. Wir führen eine Synchronisationsanalyse mit Hilfe der kontinuierlichen Wavelettransformation durch und finden einen unterschiedlichen Übergang zur Synchronisation auf den unterschiedlichen Zeitskalen. Das dritte analysierte System ist ein Netzwerkmotiv von Grenzzyklusoszillatoren. Genauer handelt es sich um ein Nabenmotiv, welches einen elementaren Grundbaustein von skalenfreien Netzwerken darstellt, das sind Netzwerke die eine bedeutende Rolle in vielen realen Anwendungen spielen. Diese Naben sind von besonderer Bedeutung für die Kommunikation und den Informationstransport in komplexen Netzwerken. Hierbei wurde eine detaillierte Untersuchung des Synchronisationsmechanismus in oszillatorischen Netzwerken mit einer breiten Frequenzverteilung durchgeführt. Insbesondere beobachten wir eine Fernsynchronisation von Netzwerkknoten, die nur indirekt über andere Oszillatoren miteinander gekoppelt sind. Wir erklären den zu Grunde liegenden Mechanismus und zeigen dessen Grenzen und Bedingungen auf. Des weiteren leiten wir einen analytischen Ausdruck für den Mechanismus her und zeigen, dass eine Informationsübertragung in reinen Phasenoszillatoren, wie beispielsweise vom Kuramototyp, eingeschränkt ist. Diese Ergebnisse konnten wir durch Experimente mit elektrischen Schaltkreisen bestätigen.
KW  - Komplexe Systeme
KW  - Synchronisation
KW  - Nichtlineare Dynamik
KW  - Datenanalyse
KW  - complex systems
KW  - synchronization
KW  - nonlinear dynamics
KW  - data analysis
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-53407
ER  - 
TY  - JOUR
A1  - Beta, Carsten
A1  - Bodenschatz, Eberhard
T1  - Microfluidic tools for quantitative studies of eukaryotic chemotaxis
JF  - European journal of cell biology
N2  - Over the past decade, microfluidic techniques have been established as a versatile platform to perform live cell experiments under well-controlled conditions. To investigate the directional responses of cells, stable concentration profiles of chemotactic factors can be generated in microfluidic gradient mixers that provide a high degree of spatial control. However, the times for built-up and switching of gradient profiles are in general too slow to resolve the intracellular protein translocation events of directional sensing of eukaryotes. Here, we review an example of a conventional microfluidic gradient mixer as well as the novel flow photolysis technique that achieves an increased temporal resolution by combining the photo-activation of caged compounds with the advantages of microfluidic chambers.
KW  - Eukaryotic chemotaxis
KW  - Dictyostelium discoideum
KW  - Microfluidics
KW  - Caged compounds
KW  - Numerical simulations
Y1  - 2011
U6  - https://doi.org/10.1016/j.ejcb.2011.05.006
SN  - 0171-9335
VL  - 90
IS  - 10
SP  - 811
EP  - 816
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Beye, Martin
A1  - Föhlisch, Alexander
T1  - A soft X-ray approach to electron-phonon interactions beyond the Born-Oppenheimer approximation
JF  - Journal of electron spectroscopy and related phenomena : the international journal on theoretical and experimental aspects of electron spectroscopy
N2  - With modern soft X-ray methods, the whole field of electron-phonon interactions becomes accessible directly in the ultrafast time domain with ultrashort pulsed X-ray sources, as well as in the energy domain through modern highly resolving spectrometers. The well-known core-hole clock approach plays an intermediate role, resolving energetic and temporal features at the same time. In this perspective paper, we review several experiments to illustrate the modern advances in the selective study of electron-phonon interactions as fundamentally determining ingredients for materials properties. We present the different complementary approaches that can be taken with soft X-ray methods to conquer this field beyond the Born-Oppenheimer approximation.
KW  - Electron-phonon coupling
KW  - Resonant inelastic X-ray scattering
KW  - X-ray emission spectroscopy
KW  - Near edge X-ray absorption fine structure
Y1  - 2011
U6  - https://doi.org/10.1016/j.elspec.2010.12.032
SN  - 0368-2048
VL  - 184
IS  - 3-6
SP  - 313
EP  - 317
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Bieneck, Steffen
A1  - Krahé, Barbara
T1  - Blaming the victim and exonerating the perpetrator in cases of rape and robbery is there a double standard?
JF  - Journal of interpersonal violence : concerned with the study and treatment of victims and perpetrators of physical and sexual violence
N2  - Research in legal decision making has demonstrated the tendency to blame the victim and exonerate the perpetrator of sexual assault. This study examined the hypothesis of a special leniency bias in rape cases by comparing them to cases of robbery. N = 288 participants received descriptions of rape and robbery of a female victim by a male perpetrator and made ratings of victim and perpetrator blame. Case scenarios varied with respect to the prior relationship (strangers, acquaintances, ex-partners) and coercive strategy (force vs. exploiting victim intoxication). More blame was attributed to the victim and less blame was attributed to the perpetrator for rape than for robbery. Information about a prior relationship between victim and perpetrator increased ratings of victim blame and decreased perceptions of perpetrator blame in the rape cases, but not in the robbery cases. The findings support the notion of a special leniency bias in sexual assault cases.
KW  - criminology
KW  - leniency bias
KW  - rape
KW  - robbery
KW  - victim blame
Y1  - 2011
U6  - https://doi.org/10.1177/0886260510372945
SN  - 0886-2605
VL  - 26
IS  - 9
SP  - 1785
EP  - 1797
PB  - Sage Publ.
CY  - Thousand Oaks
ER  - 
TY  - JOUR
A1  - Bierbach, David
A1  - Kronmarck, Claudia
A1  - Hennige-Schulz, Carmen
A1  - Stadler, Stefan
A1  - Plath, Martin
T1  - Sperm competition risk affects male mate choice copying
JF  - Behavioral ecology and sociobiology
N2  - Mate choice copying was mostly described as a strategy employed by females to assess the quality of potential mates, but also males can copy other males' mate choice. An open question in this context is whether and how copying males evaluate sperm competition risk, as mating with a female that has already copulated with another male obviously sets the stage for intense sperm competition (i.e., in species with internal fertilization). Using the livebearing Atlantic molly (Poecilia mexicana) as a model, we asked (a) whether males of that species indeed copy other males' choices, and if they do so, (b) whether copying males strategically adjust their behavior to sperm competition risk. We used an approach where focal males could first choose to associate with a large or a small stimulus female. Mate choice tests were then repeated after an "observation phase" during which either no model male was present (treatment 1, control) or the previously non-preferred female could be seen associating (treatment 2) or physically interacting (treatment 3) with a model male. We found that, after the observation phase, males spent considerably more time with the previously non-preferred female in treatment (2), i.e., they copied the model male's choice. This effect was much weaker during treatment (3) where sexual interactions between the model male and the formerly non-preferred female were allowed. Males, therefore, seem to adjust their copying behavior strategically to the perceived risk of sperm competition.
KW  - Communication networks
KW  - Mate choice copying
KW  - Non-independent mate choice
KW  - Sperm competition
KW  - Social environment
Y1  - 2011
U6  - https://doi.org/10.1007/s00265-011-1177-3
SN  - 0340-5443
VL  - 65
IS  - 9
SP  - 1699
EP  - 1707
PB  - Springer
CY  - New York
ER  - 
TY  - GEN
A1  - Bierbach, David
A1  - Schulte, Matthias
A1  - Herrmann, Nina
A1  - Tobler, Michael
A1  - Stadler, Stefan
A1  - Jung, Christian T.
A1  - Kunkel, Benjamin
A1  - Riesch, Rüdiger
A1  - Klaus, Sebastian
A1  - Ziege, Madlen
A1  - Indy, Jeane Rimber
A1  - Arias-Rodriguez, Lenin
A1  - Plath, Martin
T1  - Predator-induced changes of female mating preferences
BT  - innate and experiential effects
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Background

In many species males face a higher predation risk than females because males display elaborate traits that evolved under sexual selection, which may attract not only females but also predators. Females are, therefore, predicted to avoid such conspicuous males under predation risk. The present study was designed to investigate predator-induced changes of female mating preferences in Atlantic mollies (Poecilia mexicana). Males of this species show a pronounced polymorphism in body size and coloration, and females prefer large, colorful males in the absence of predators.
Results

In dichotomous choice tests predator-naïve (lab-reared) females altered their initial preference for larger males in the presence of the cichlid Cichlasoma salvini, a natural predator of P. mexicana, and preferred small males instead. This effect was considerably weaker when females were confronted visually with the non-piscivorous cichlid Vieja bifasciata or the introduced non-piscivorous Nile tilapia (Oreochromis niloticus). In contrast, predator experienced (wild-caught) females did not respond to the same extent to the presence of a predator, most likely due to a learned ability to evaluate their predators' motivation to prey.
Conclusions

Our study highlights that (a) predatory fish can have a profound influence on the expression of mating preferences of their prey (thus potentially affecting the strength of sexual selection), and females may alter their mate choice behavior strategically to reduce their own exposure to predators. (b) Prey species can evolve visual predator recognition mechanisms and alter their mate choice only when a natural predator is present. (c) Finally, experiential effects can play an important role, and prey species may learn to evaluate the motivational state of their predators.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 984 
KW  - sexual selection
KW  - female choice
KW  - non-independent mate choice
KW  - predator recognition
KW  - Poecilia mexicana
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431099
SN  - 1866-8372
IS  - 984
ER  - 
TY  - JOUR
A1  - Bierbach, David
A1  - Schulte, Matthias
A1  - Herrmann, Nina
A1  - Tobler, Michael
A1  - Stadler, Stefan
A1  - Jung, Christian T.
A1  - Kunkel, Benjamin
A1  - Riesch, Rüdiger
A1  - Klaus, Sebastian
A1  - Ziege, Madlen
A1  - Rimber Indy, Jeane
A1  - Arias-Rodriguez, Lenin
A1  - Plath, Martin
T1  - Predator-induced changes of female mating preferences innate and experiential effects
JF  - BMC evolutionary biology
N2  - Background: In many species males face a higher predation risk than females because males display elaborate traits that evolved under sexual selection, which may attract not only females but also predators. Females are, therefore, predicted to avoid such conspicuous males under predation risk. The present study was designed to investigate predator-induced changes of female mating preferences in Atlantic mollies (Poecilia mexicana). Males of this species show a pronounced polymorphism in body size and coloration, and females prefer large, colorful males in the absence of predators.
 Results: In dichotomous choice tests predator-naive (lab-reared) females altered their initial preference for larger males in the presence of the cichlid Cichlasoma salvini, a natural predator of P. mexicana, and preferred small males instead. This effect was considerably weaker when females were confronted visually with the non-piscivorous cichlid Vieja bifasciata or the introduced non-piscivorous Nile tilapia (Oreochromis niloticus). In contrast, predator experienced (wild-caught) females did not respond to the same extent to the presence of a predator, most likely due to a learned ability to evaluate their predators' motivation to prey.
 Conclusions: Our study highlights that (a) predatory fish can have a profound influence on the expression of mating preferences of their prey (thus potentially affecting the strength of sexual selection), and females may alter their mate choice behavior strategically to reduce their own exposure to predators. (b) Prey species can evolve visual predator recognition mechanisms and alter their mate choice only when a natural predator is present. (c) Finally, experiential effects can play an important role, and prey species may learn to evaluate the motivational state of their predators.
KW  - Sexual selection
KW  - female choice
KW  - non-independent mate choice
KW  - predator recognition
KW  - Poecilia mexicana
Y1  - 2011
U6  - https://doi.org/10.1186/1471-2148-11-190
SN  - 1471-2148
VL  - 11
IS  - 3-4
PB  - BioMed Central
CY  - London
ER  - 
TY  - THES
A1  - Bierbaum, Veronika
T1  - Chemomechanical coupling and motor cycles of the molecular motor myosin V
T1  - Chemomechanische Kopplung und Motorzyklen für den molekularen Motor Myosin V
N2  - In the living cell, the organization of the complex internal structure relies to a large extent on molecular motors. Molecular motors are proteins that are able to convert chemical energy from the hydrolysis of adenosine triphosphate (ATP) into mechanical work. Being about 10 to 100 nanometers in size, the molecules act on a length scale, for which thermal collisions have a considerable impact onto their motion. In this way, they constitute paradigmatic examples of thermodynamic machines out of equilibrium. This study develops a theoretical description for the energy conversion by the molecular motor myosin V, using many different aspects of theoretical physics. Myosin V has been studied extensively in both bulk and single molecule experiments. Its stepping velocity has been characterized as a function of external control parameters such as nucleotide concentration and applied forces. In addition, numerous kinetic rates involved in the enzymatic reaction of the molecule have been determined. For forces that exceed the stall force of the motor, myosin V exhibits a 'ratcheting' behaviour: For loads in the direction of forward stepping, the velocity depends on the concentration of ATP, while for backward loads there is no such influence. Based on the chemical states of the motor, we construct a general network theory that incorporates experimental observations about the stepping behaviour of myosin V. The motor's motion is captured through the network description supplemented by a Markov process to describe the motor dynamics. This approach has the advantage of directly addressing the chemical kinetics of the molecule, and treating the mechanical and chemical processes on equal grounds. We utilize constraints arising from nonequilibrium thermodynamics to determine motor parameters and demonstrate that the motor behaviour is governed by several chemomechanical motor cycles. In addition, we investigate the functional dependence of stepping rates on force by deducing the motor's response to external loads via an appropriate Fokker-Planck equation. For substall forces, the dominant pathway of the motor network is profoundly different from the one for superstall forces, which leads to a stepping behaviour that is in agreement with the experimental observations. The extension of our analysis to Markov processes with absorbing boundaries allows for the calculation of the motor's dwell time distributions. These reveal aspects of the coordination of the motor's heads and contain direct information about the backsteps of the motor. Our theory provides a unified description for the myosin V motor as studied in single motor experiments.
N2  - Die hier vorgelegte Arbeit entwickelt unter Verwendung vieler verschiedener Aspekte der statistischen Physik eine Theorie der chemomechanischen Kopplung für den Energieumsatz des molekularen Motors Myosin V. Das Myosin V ist sowohl in chemokinetischen wie in Einzelmolekülexperimenten grundlegend untersucht worden. Seine Schrittgeschwindigkeit ist in Abhängigkeit verschiedener externer Parameter, wie der Nukleotidkonzentration und einer äußeren Kraft, experimentell bestimmt. Darüber hinaus ist eine große Anzahl verschiedener chemokinetischer Raten, die an der enzymatischen Reaktion des Moleküls beteiligt sind, quantitativ erfasst. Unter der Wirkung externer Kräfte, die seine Anhaltekraft überschreiten, verhält sich der Motor wie eine Ratsche: Für Kräfte, die entlang der Schrittbewegung des Motors wirken, hängt seine Geschwindigkeit von der ATP-Konzentration ab, für rückwärts angreifende Kräfte jedoch ist die Bewegung des Motors unabhängig von ATP. Auf der Grundlage der chemischen Zustände des Motors wird eine Netzwerktheorie aufgebaut, die die experimentellen Beobachtungen des Schrittverhaltens für Myosin V einschließt. Diese Netzwerkbeschreibung dient als Grundlage für einen Markovprozess, der die Dynamik des Motors beschreibt. Die Verwendung diskreter Zustände bietet den Vorteil der direkten Erfassung der chemischen Kinetik des Moleküls. Darüber hinaus werden chemische und mechanische Eigenschaften des Motors in gleichem Maße im Modell berücksichtigt. Durch die Erfassung der Enzymkinetik mittels eines stochastischen Prozesses lässt sich die Motordynamik mit Hilfe des stationären Zustands der Netzwerkdarstellung beschreiben. Um diesen zu bestimmen, verwenden wir eine graphentheoretische Methode, die auf Kirchhoff zurückgreift. Wir zeigen in Einklang mit den Gesetzen der Thermodynamik für Nichtgleichgewichtssysteme, dass das Schrittverhalten des Motors von mehreren chemomechanischen Zyklen beeinflusst wird. Weiterhin untersuchen wir das funktionale Verhalten mechanischer Schrittraten in Abhängigkeit der äußeren Kraft unter Verwendung einer geeigneten Fokker-Planck-Gleichung. Hierfür wird auf die Theorie einer kontinuierlichen Beschreibung von molekularen Methoden zurückgegriffen. Wir berechnen Größen wie die mittlere Schrittgeschwindigkeit, das Verhältnis von Vorwärts- und Rückwärtsschritten, und die Lauflänge des Motors in Abhängigkeit einer äußeren angreifenden Kraft sowie der Nukleotidkonzentration, und vergleichen diese mit experimentellen Daten. Für Kräfte, die kleiner als die Anhaltekraft des Motors sind, unterscheidet sich der chemomechanische Zyklus grundlegend von demjenigen, der für große Kräfte dominiert. Diese Eigenschaft resultiert in einem Schrittverhalten, das mit den experimentellen Beobachtungen übereinstimmt. Es ermöglicht weiterhin die Zerlegung des Netzwerks in einzelne Zyklen, die die Bewegung des Motors für verschiedene Bereiche externer Kräfte erfassen. Durch die Erweiterung unseres Modells auf Markovprozesse mit absorbierenden Zuständen können so die Wartezeitenverteilungen für einzelne Zyklen des Motors analytisch berechnet werden. Sie erteilen Aufschluss über die Koordination des Motors und enthalten zudem direkte Informationen über seine Rückwärtsschritte, die experimentell nicht erfasst sind. Für das gesamte Netzwerk werden die Wartezeitenverteilungen mit Hilfe eines Gillespie-Algorithmus bestimmt. Unsere Theorie liefert eine einheitliche Beschreibung der Eigenschaften von Myosin V, die in Einzelmolekülexperimenten erfasst werden können.
KW  - statistische Physik
KW  - Markov-Prozesse
KW  - molekulare Motoren
KW  - statistical physics
KW  - markov processes
KW  - molecular motors
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-53614
ER  - 
TY  - JOUR
A1  - Biermann, Ursula
A1  - Meier, Michael A. R.
A1  - Butte, Werner
A1  - Metzger, Jürgen O.
T1  - Cross-metathesis of unsaturated triglycerides with methyl acrylate  synthesis of a dimeric metathesis product
JF  - European journal of lipid science and technology
N2  - Highly functionalized dimeric triglycerides, such as compound 2, are obtained as minor products besides branched macromolecules from the acyclic triene metathesis (ATMET) polymerization of unsaturated triglycerides such as glyceryl triundec-10-enoate 1 and methyl acrylate (MA) in the presence of the second generation Hoveyda-Grubbs catalyst. The formed amount of interesting products of lower molecular weight during the ATMET reaction depends on the ratio of MA and triglyceride, reaction time, and temperature. We isolated the dimeric metathesis product 2 and synthesized the respective partially hydrogenated dimer 3 regioselectivly in a seven step reaction sequence starting from 10-undecenoic acid 7 and glycerol. Product 3 was unambiguously characterized by (13)C and (1)H NMR and MS as well as the further intermediate products of the seven step reaction including 10,11 bromo-undecanoic acid 8, the respective brominated 1,3-diglyceride 9, the brominated 1,3-triglyceride 6, and the self-metathesis products 4 and 5 which were isolated and purified.
KW  - Highly functionalized dimeric triglycerides
KW  - Olefin self- and cross-metathesis
KW  - Renewable resources
Y1  - 2011
U6  - https://doi.org/10.1002/ejlt.201000109
SN  - 1438-7697
VL  - 113
IS  - 1
SP  - 39
EP  - 45
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Biglu, S.
A1  - Biglu, M. H.
A1  - Falk, C.
T1  - Scientometric study of scientific production n psyciatry
T2  - European psychiatry : the journal of the Association of European Psychiatrists
Y1  - 2011
SN  - 0924-9338
VL  - 26
IS  - 1
PB  - Elsevier
CY  - Paris
ER  - 
TY  - JOUR
A1  - Binzer, Amrei
A1  - Brose, Ulrich
A1  - Curtsdotter, Alva
A1  - Ekloef, Anna
A1  - Rall, Bjoern C.
A1  - Riede, Jens O.
A1  - de Castro, Francisco
T1  - The susceptibility of species to extinctions in model communities
JF  - Basic and applied ecology : Journal of the Gesellschaft für Ökologie
N2  - Despite the fact that the loss of a species from a community has the potential to cause a dramatic decline in biodiversity, for example through cascades of secondary extinctions, little is known about the factors contributing to the extinction risk of any particular species. Here we expand earlier modeling approaches using a dynamic food-web model that accounts for bottom-up as well as top-down effects. We investigate what factors influence a species' extinction risk and time to extinction of the non-persistent species.
 We identified three basic properties that affect a species' risk of extinction. The highest extinction risk is born by species with (1) low energy input (e.g. high trophic level), (2) susceptibility to the loss of energy pathways (e.g. specialists with few prey species) and (3) dynamic instability (e.g. low Hill exponent and reliance on homogeneous energy channels when feeding on similarly sized prey).
 Interestingly, and different from field studies, we found that the trophic level and not the body mass of a species influences its extinction risk. On the other hand, body mass is the single most important factor determining the time to extinction of a species, resulting in small species dying first. This suggests that in the field the trophic level might have more influence on the extinction risk than presently recognized.
KW  - Extinction risk
KW  - Allometry
KW  - Dynamic modeling
Y1  - 2011
U6  - https://doi.org/10.1016/j.baae.2011.09.002
SN  - 1439-1791
VL  - 12
IS  - 7
SP  - 590
EP  - 599
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Birkhofer, Klaus
A1  - Diekoetter, Tim
A1  - Boch, Steffen
A1  - Fischer, Markus
A1  - Müller, Jörg
A1  - Socher, Stephanie
A1  - Wolters, Volkmar
T1  - Soil fauna feeding activity in temperate grassland soils increases with legume and grass species richness
JF  - Soil biology & biochemistry
N2  - Edaphic fauna contributes to important ecosystem functions in grassland soils such as decomposition and nutrient mineralization. Since this functional role is likely to be altered by global change and associated shifts in plant communities, a thorough understanding of large scale drivers on below-ground processes independent of regional differences in soil type or climate is essential. We investigated the relationship between abiotic (soil properties, management practices) and biotic (plant functional group composition, vegetation characteristics, soil fauna abundance) predictors and feeding activity of soil fauna after accounting for sample year and study region. Our study was carried out over a period of two consecutive years in 92 agricultural grasslands in three regions of Germany, spanning a latitudinal gradient of more than 500 km. A structural equation model suggests that feeding activity of soil fauna as measured by the bait-lamina test was positively related to legume and grass species richness in both years. Most probably, a diverse vegetation promotes feeding activity of soil fauna via alterations of both microclimate and resource availability. Feeding activity of soil fauna also increased with earthworm biomass via a pathway over Collembola abundance. The effect of earthworms on the feeding activity in soil may be attributed to their important role as ecosystem engineers. As no additional effects of agricultural management such as fertilization, livestock density or number of cuts on bait consumption were observed, our results suggest that the positive effect of legume and grass species richness on the feeding activity in soil fauna is a general one that will not be overruled by regional differences in management or environmental conditions. We thus suggest that agri-environment schemes aiming at the protection of belowground activity and associated ecosystem functions in temperate grasslands may generally focus on maintaining plant diversity, especially with regard to the potential effects of climate change on future vegetation structure.
KW  - Above-belowground interactions
KW  - Bait lamina
KW  - Biodiversity ecosystem function research
KW  - Decomposition
KW  - Plant functional groups
KW  - Soil fauna
KW  - Spatial scale
Y1  - 2011
U6  - https://doi.org/10.1016/j.soilbio.2011.07.008
SN  - 0038-0717
VL  - 43
IS  - 10
SP  - 2200
EP  - 2207
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Blaha, Karen A.
A1  - Pikovskij, Arkadij
A1  - Rosenblum, Michael
A1  - Clark, Matthew T.
A1  - Rusin, Craig G.
A1  - Hudson, John L.
T1  - Reconstruction of two-dimensional phase dynamics from experiments on coupled oscillators
JF  - Physical review : E, Statistical, nonlinear and soft matter physics
N2  - Phase models are a powerful method to quantify the coupled dynamics of nonlinear oscillators from measured data. We use two phase modeling methods to quantify the dynamics of pairs of coupled electrochemical oscillators, based on the phases of the two oscillators independently and the phase difference, respectively. We discuss the benefits of the two-dimensional approach relative to the one-dimensional approach using phase difference. We quantify the dependence of the coupling functions on the coupling magnitude and coupling time delay. We show differences in synchronization predictions of the two models using a toy model. We show that the two-dimensional approach reveals behavior not detected by the one-dimensional model in a driven experimental oscillator. This approach is broadly applicable to quantify interactions between nonlinear oscillators, especially where intrinsic oscillator sensitivity and coupling evolve with time.
Y1  - 2011
U6  - https://doi.org/10.1103/PhysRevE.84.046201
SN  - 1539-3755
VL  - 84
IS  - 4
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Blakesley, James C.
A1  - Neher, Dieter
T1  - Relationship between energetic disorder and open-circuit voltage in bulk heterojunction organic solar cells
JF  - Physical review : B, Condensed matter and materials physics
N2  - We simulate organic bulk heterojunction solar cells. The effects of energetic disorder are incorporated through a Gaussian or exponential model of density of states. Analytical models of open-circuit voltage (V(OC)) are derived from the splitting of quasi-Fermi potentials. Their predictions are backed up by more complex numerical device simulations including effects such as carrier-density-dependent charge-carrier mobilities. It is predicted that the V(OC) depends on: (1) the donor-acceptor energy gap; (2) charge-carrier recombination rates; (3) illumination intensity; (4) the contact work functions (if not in the pinning regime); and (5) the amount of energetic disorder. A large degree of energetic disorder, or a high density of traps, is found to cause significant reductions in V(OC). This can explain why V(OC) is often less than expected in real devices. Energetic disorder also explains the nonideal temperature and intensity dependence of V(OC) and the superbimolecular recombination rates observed in many real bulk heterojunction solar cells.
Y1  - 2011
U6  - https://doi.org/10.1103/PhysRevB.84.075210
SN  - 1098-0121
VL  - 84
IS  - 7
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Blakesley, James C.
A1  - Schubert, Marcel
A1  - Steyrleuthner, Robert
A1  - Chen, Zhihua
A1  - Facchetti, Antonio
A1  - Neher, Dieter
T1  - Time-of-flight measurements and vertical transport in a high electron-mobility polymer
JF  - Applied physics letters
N2  - We investigate charge transport in a high-electron mobility polymer, poly(N, N-bis 2-octyldodecyl-naphthalene-1,4,5,8-bis dicarboximide-2,6-diyl-alt-5,5-2,2-bithiophene) [P(NDI2OD-T2), Polyera ActivInk (TM) N2200]. Time-of-flight measurements reveal electron mobilities approaching those measured in field-effect transistors, the highest ever recorded in a conjugated polymer using this technique. The modest temperature dependence and weak dispersion of the transients indicate low energetic disorder in this material. Steady-state electron-only current measurements reveal a barrier to injection of about 300 meV. We propose that this barrier is located within the P(NDI2OD-T2) film and arises from molecular orientation effects.
Y1  - 2011
U6  - https://doi.org/10.1063/1.3657827
SN  - 0003-6951
VL  - 99
IS  - 18
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Bland-Hawthorn, Joss
A1  - Ellis, S. C.
A1  - Leon-Saval, S. G.
A1  - Haynes, R.
A1  - Roth, Martin M.
A1  - Löhmannsröben, Hans-Gerd
A1  - Horton, A. J.
A1  - Cuby, J. -G.
A1  - Birks, T. A.
A1  - Lawrence, J. S.
A1  - Gillingham, P.
A1  - Ryder, S. D.
A1  - Trinh, C.
T1  - A complex multi-notch astronomical filter to suppress the bright infrared sky
JF  - Nature Communications
N2  - A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as redshifted starlight from distant galaxies appears at these wavelengths. The atmospheric emission between 1,000 and 1,800 nm arises almost entirely from a forest of extremely bright, very narrow hydroxyl emission lines that varies on timescales of minutes. The astronomical community has long envisaged the prospect of selectively removing these lines, while retaining high throughput between them. Here we demonstrate such a filter for the first time, presenting results from the first on-sky tests. Its use on current 8 m telescopes and future 30 m telescopes will open up many new research avenues in the years to come.
Y1  - 2011
U6  - https://doi.org/10.1038/ncomms1584
SN  - 2041-1723
VL  - 2
IS  - 50
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - THES
A1  - Blaser, Lilian
T1  - Bayesian networks for tsunami early warning
Y1  - 2011
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Blaum, Niels
A1  - Mosner, Eva
A1  - Schwager, Monika
A1  - Jeltsch, Florian
T1  - How functional is functional?Ecological groupings in terrestrial animal ecology - towards an animal functional type approach
JF  - Biodiversity and conservation
N2  - Understanding mechanisms to predict changes in plant and animal communities is a key challenge in ecology. The need to transfer knowledge gained from single species to a more generalized approach has led to the development of categorization systems where species' similarities in life strategies and traits are classified into ecological groups (EGs) like functional groups/types or guilds. While approaches in plant ecology undergo a steady improvement and refinement of methodologies, progression in animal ecology is lagging behind. With this review, we aim to initiate a further development of functional classification systems in animal ecology, comparable to recent developments in plant ecology. We here (i) give an overview of terms and definitions of EGs in animal ecology, (ii) discuss existing classification systems, methods and application areas of EGs (focusing on terrestrial vertebrates), and (iii) provide a "roadmap towards an animal functional type approach" for improving the application of EGs and classifications in animal ecology. We found that an animal functional type approach requires: (i) the identification of core traits describing species' dependency on their habitat and life history traits, (ii) an optimization of trait selection by clustering traits into hierarchies, (iii) the assessment of "soft traits" as substitute for hardly measurable traits, e.g. body size for dispersal ability, and (iv) testing of delineated groups for validation including experiments.
KW  - Ecological classification
KW  - Functional type
KW  - Guild
KW  - Functional trait
KW  - Trait selection
KW  - Effect group
KW  - Response group
KW  - Environmental relationships
Y1  - 2011
U6  - https://doi.org/10.1007/s10531-011-9995-1
SN  - 0960-3115
VL  - 20
IS  - 11
SP  - 2333
EP  - 2345
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Bleger, David
A1  - Dokic, Jadranka
A1  - Peters, Maike V.
A1  - Grubert, Lutz
A1  - Saalfrank, Peter
A1  - Hecht, Stefan
T1  - Electronic decoupling approach to quantitative photoswitching in linear multiazobenzene architectures
JF  - The journal of physical chemistry : B, Condensed matter, materials, surfaces, interfaces & biophysical chemistry
N2  - A strategy to optimize the photoswitching efficiency of rigid, linear multiazobenzene constructs is presented. It consists of introducing large dihedral angles between azobenzene moieties linked via aryl-aryl connections in their para positions. Four bisazobenzenes exhibiting different dihedral angles as well as three single azobenzene reference compounds have been synthesized, and their switching behavior has been studied as well as experimentally and theoretically analyzed. As the dihedral angle between the two azobenzene units increases and consequently the electronic conjugation decreases, the photochromic characteristics improve, finally leading to individual azobenzene switches operating independently in the case of the perpendicular ortho,ortho,ortho',ortho'-tetramethyl biphenyl linker. The electronic decoupling leads to efficient separation of the absorption spectra of the involved switching states and hence by choosing the appropriate irradiation wavelength, an almost quantitative E -> Z photoisomerization up to 97% overall Z-content can be achieved. In addition, thermal Z -> E isomerization processes become independent of each other with increasing decoupling. The electronic decoupling could furthermore be proven by electrochemistry. The experimental data are supported by theory, and calculations additionally provide mechanistic insight into the preferred pathway for the thermal Z,Z -> Z,E -> E,E isomerization via inversion on the inner N-atoms. Our decoupling approach outlined herein provides the basis for constructing rigid rod architectures composed of multiple azobenzene photochromes, which display practically quantitative photoswitching properties, a necessary prerequisite to achieve highly efficient transduction of light energy directly into motion.
Y1  - 2011
U6  - https://doi.org/10.1021/jp2044114
SN  - 1520-6106
VL  - 115
IS  - 33
SP  - 9930
EP  - 9940
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Blenau, Wolfgang
A1  - Thamm, Markus
T1  - Distribution of serotonin (5-HT) and its receptors in the insect brain with focus on the mushroom bodies lessons from Drosophila melanogaster and Apis mellifera
JF  - Arthropod structure & development
N2  - The biogenic amine serotonin (5-hydroxytryptamine, 5-HT) plays a key role in regulating and modulating various physiological and behavioral processes in both protostomes and deuterostomes. The specific functions of serotonin are mediated by its binding to and subsequent activation of membrane receptors. The vast majority of these receptors belong to the superfamily of G-protein-coupled receptors. We report here the in vivo expression pattern of a recently characterized 5-HT(1) receptor of the honeybee Apis mellifera (Am5-HT(1A)) in the mushroom bodies. In addition, we summarize current knowledge on the distribution of serotonin and serotonin receptor subtypes in the brain and specifically in the mushroom bodies of the fruit fly Drosophila melanogaster and the honeybee. Functional studies in these two species have shown that serotonergic signaling participates in various behaviors including aggression, sleep, circadian rhythms, responses to visual stimuli, and associative learning. The molecular, pharmacological, and functional properties of identified 5-HT receptor subtypes from A. mellifera and D. melanogaster will also be summarized in this review.
KW  - Apis mellifera
KW  - G-protein-coupled receptor
KW  - Drosophila melanogaster
KW  - Mushroom body
KW  - Serotonin
Y1  - 2011
U6  - https://doi.org/10.1016/j.asd.2011.01.004
SN  - 1467-8039
VL  - 40
IS  - 5
SP  - 381
EP  - 394
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Blomeyer, Dorothea
A1  - Buchmann, Arlette F.
A1  - Schmid, Brigitte
A1  - Jennen-Steinmetz, Christine
A1  - Schmidt, Martin H.
A1  - Banaschewski, Tobias
A1  - Laucht, Manfred
T1  - Age at first drink moderates the impact of current stressful life events on drinking behavior in young adults
JF  - Alcoholism : clinical and experimental research ; the official journal of the American Medical Society on Alcoholism and the Research Society on Alcoholism
N2  - Background:
 Recent evidence from animal experiments and studies in humans suggests that early age at first drink (AFD) may lead to higher stress-induced drinking. The present study aimed to extend these findings by examining whether AFD interacted with stressful life events (SLE) and/or with daily hassles regarding the impact on drinking patterns among young adults.
 Method:
 In 306 participants of an epidemiological cohort study, AFD was assessed together with SLE during the past 3 years, daily hassles in the last month, and drinking behavior at age 22. As outcome variables, 2 variables were derived, reflecting different aspects of alcohol use: the amount of alcohol consumed in the last month and the drinking frequency, indicated by the number of drinking days in the last month.
 Results:
 Linear regression models revealed an interaction effect between the continuous measures of AFD and SLE on the amount of alcohol consumed. The earlier young adults had their first alcoholic drink and the higher the levels of SLE they were exposed to, the disproportionately more alcohol they consumed. Drinking frequency was not affected by an interaction of these variables, while daily hassles and their interaction with AFD were unrelated to drinking behavior.
 Conclusions:
 These findings highlight the importance of early age at drinking onset as a risk factor for later heavy drinking under high load of SLE. Prevention programs should aim to raise age at first contact with alcohol. Additionally, support in stressful life situations and the acquisition of effective coping strategies might prevent heavy drinking in those with earlier drinking onset.
KW  - Age at First Drink
KW  - Drinking Behavior
KW  - Longitudinal Study
KW  - Stressful Life Events
KW  - Daily Hassles
Y1  - 2011
U6  - https://doi.org/10.1111/j.1530-0277.2011.01447.x
SN  - 0145-6008
VL  - 35
IS  - 6
SP  - 1142
EP  - 1148
PB  - Wiley-Blackwell
CY  - Malden
ER  - 
TY  - THES
A1  - Boeche, Corrado
T1  - Chemical gradients in the Milky Way from unsupervised chemical abundances measurements of the RAVE spectroscopic data set
T1  - Chemische Gradienten in der Milchstraße aus unüberwachten chemischen Häufigkeitsmessungen aus dem RAVE spektroskopischen Datenset
N2  - The present thesis was born and evolved within the RAdial Velocity Experiment (RAVE) with the goal of measuring chemical abundances from the RAVE spectra and exploit them to investigate the chemical gradients along the plane of the Galaxy to provide constraints on possible Galactic formation scenarios. RAVE is a large spectroscopic survey which aims to observe spectroscopically ~10^6 stars by the end of 2012 and measures their radial velocities, atmospheric parameters and chemical abundances. The project makes use of the UK Schmidt telescope at Australian Astronomical Observatory (AAO) in Siding Spring, Australia, equipped with the multiobject spectrograph 6dF. To date, RAVE collected and measured more than 450,000 spectra. The precision of the chemical abundance estimations depends on the reliability of the atomic and atmosphere parameters adopted (in particular the oscillator strengths of the absorption lines and the effective temperature, gravity, and metallicity of the stars measured). Therefore we first identified 604 absorption lines in the RAVE wavelength range and refined their oscillator strengths with an inverse spectral analysis. Then, we improved the RAVE stellar parameters by modifying the RAVE pipeline and the spectral library the pipeline rely on. The modifications removed some systematic errors in stellar parameters discovered during this work. To obtain chemical abundances, we developed two different processing pipelines. Both of them perform chemical abundances measurements by assuming stellar atmospheres in Local Thermodynamic Equilibrium (LTE). The first one determines elements abundances from equivalent widths of absorption lines. Since this pipeline showed poor sensibility on abundances relative to iron, it has been superseded. The second one exploits the chi^2 minimization technique between observed and model spectra. Thanks to its precision, it has been adopted for the creation of the RAVE chemical catalogue. This pipeline provides abundances with uncertains of about ~0.2dex for spectra with signal-to-noise ratio S/N>40 and ~0.3dex for spectra with 20>S/N>40. For this work, the pipeline measured chemical abundances up to 7 elements for 217,358 RAVE stars. With these data we investigated the chemical gradients along the Galactic radius of the Milky Way. We found that stars with low vertical velocities |W| (which stay close to the Galactic plane) show an iron abundance gradient in agreement with previous works (~-0.07$ dex kpc^-1) whereas stars with larger |W| which are able to reach larger heights above the Galactic plane, show progressively flatter gradients. The gradients of the other elements follow the same trend. This suggests that an efficient radial mixing acts in the Galaxy or that the thick disk formed from homogeneous interstellar matter. In particular, we found hundreds of stars which can be kinetically classified as thick disk stars exhibiting a chemical composition typical of the thin disk. A few stars of this kind have already been detected by other authors, and their origin is still not clear. One possibility is that they are thin disk stars kinematically heated, and then underwent an efficient radial mixing process which blurred (and so flattened) the gradient. Alternatively they may be a transition population" which represents an evolutionary bridge between thin and thick disk. Our analysis shows that the two explanations are not mutually exclusive. Future follow-up high resolution spectroscopic observations will clarify their role in the Galactic disk evolution.
N2  - Die vorliegende Doktorarbeit wurde im Rahmen des RAdial Velocity Experiment (RAVE) angefertigt. Ihr Ziel ist es, chemische Elementhäufigkeiten an RAVE-Spektren zu messen und zur Untersuchung chemischer Gradienten in der Milchstrassenebene zu benutzen, um verschieden Szenarien der Galaxienentstehung einzugrenzen. RAVE ist eine große spektrokopische Durchmusterung, deren Ziel es ist, bis zum Ende des Jahres 2012 insgesamt 10^6 Sterne zu spektroskopieren, um deren Radialgeschwindigkeiten, sternatmosphärische Parameter und chemische Häufigkeiten zu messen. Das Projekt benutzt das UK Schmidt Teleskop am Australian Astronomical Observatory (AAO) in Siding Spring, Australien, welches mit dem Multiobjekt-Spektrographen 6dF bestückt ist. Bis heute hat RAVE die Spektren von mehr als 450,000 Sternen gesammelt und untersucht. Die Genauigkeit, mit der die Elementhäufigkeiten abgeschätzt werden können, hängt von der Zuverlässigkeit der verwendeten Parameter, (insbesondere der Oszillatorstärken der Absorptionslinien sowie von der effektiven Temperatur, Schwerebeschleunigung und der Metallizität des gemessenen Sterns) ab. Daher identifizierten wir zunächst 604 Absorptionslinien im Wellenlängenbereich von RAVE und verbesserten deren Oszillatorstärken durch eine inverse Spektralanalyse. Dann wurden die stellaren Parameter von RAVE verbessert, indem die RAVE Pipeline und die stellaren Parameter, auf denen sie beruht, modifiziert wurden. Die Änderungen eliminierten einen Teil der systematischen Fehler von stellaren Parametern, die im Laufe dieser Arbeit gefunden wurden. Um Elementhäufigkeiten zu bestimmen, haben wir zwei verschiedene Prozessierungs-Pipelines entwickelt. Beide berechnen die Elementhäufigkeiten unter der Annahme von Sternatmosphären im lokalen thermischen Gleichgewicht (local thermal equilibrium, LTE). Die erste Pipeline berechnete Elemenhäufigkeiten anhand der Äquivalentbreiten von Absorptionslinien. Da diese Methode eine geringe Empfindlichkeit für die Elementhäufigeiten relativ zu Eisen erreichte, wurde sie ersetzt. Die neue Pipeline benutzt chi^2-Fits von Modellspektren an die beobachteten Spektren. Dank Ihrer Präzision wurde diese für die Erstellung des RAVE-Katalogs von Elementhäufigkeiten verwendet. Diese Pipeline liefert Elementhäufigkeiten mit einer Genauigkeit von ~0.2dex, während für Spektren mit 20>S/N>40 immerhin noch ~0.3dex Genauigkeit erreicht werden. Für die vorliegende Arbeit wurden für 217.358 Sterne die Häufigkeiten von sieben chemischen Elementen bestimmt. Mit diesen Daten wurde der radiale chemische Gradient unserer Milchstraße untersucht. Wir finden, dass Sterne mit kleinen vertikalen Geschwindigkeiten |W|, die also nahe der galaktischen Ebene bleiben, einen radialen Gradienten der Eisenhäufigkeit zeigen, der mit früheren Studien übereinstimmt (~-0.07 dex Kpc^-1), während Sterne mit großen |W|, also solche, die größere galaktische Höhen erreichen, einen progressiv flachere Gradienten zeigen. Die Gradienten der anderen Element folgen dem gleichen Trend. Das lässt darauf schließen, dass entweder die Durchmischung der galaktischen dicken Scheibe effizient arbeitet oder aber dass die dicke Scheibe aus interstellarer Materie gebildet wurde, die chemisch recht homogen war. Speziell fanden wir hunderte von Sternen, die zwar kinematisch als zur dicken Scheibe zugehörig klassifiziert werden können, die aber die typische chemische Zusammensetzung der dünnen Scheibe aufweisen. Einige wenige dieser Sterne wurden bereits von anderen Autoren entdeckt, aber ihre Herkunft bleibt immer noch unklar. Eine Möglichkeit ist, dass die Sterne der dünnen Scheibe kinematische geheizt werden, sodass sie effizienter radial gemischt werden, was die chemischen Gradienten verwischt und auch flacher macht. Alternativ dazu könnten diese Sterne einer "Übergangspopulation" angehören, welche hinsichtlich der Scheibenevolution die Verbindung zwischen der dünnen und der dicken Scheibe darstellt. Unsere Untersuchung zeigt, dass sich diese beiden Erklärungen gegenseitig nicht ausschließen. Künftige Nachspektroskopierung mit hoher Auflösung wird die Rolle dieser Sterne in der Entwicklungsgeschichte der galaktischen Scheibe aufklären.
KW  - Galaxie
KW  - Milchstraße
KW  - Spektroskopie
KW  - chemische Häufigkeiten
KW  - Galaxy
KW  - Milky Way
KW  - Spectroscopy
KW  - Chemical Abundances
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-52478
ER  - 
TY  - JOUR
A1  - Bog, Anja
A1  - Plattner, Hasso
A1  - Zeier, Alexander
T1  - A mixed transaction processing and operational reporting benchmark
JF  - Information systems frontiers
N2  - The importance of reporting is ever increasing in today's fast-paced market environments and the availability of up-to-date information for reporting has become indispensable. Current reporting systems are separated from the online transaction processing systems (OLTP) with periodic updates pushed in. A pre-defined and aggregated subset of the OLTP data, however, does not provide the flexibility, detail, and timeliness needed for today's operational reporting. As technology advances, this separation has to be re-evaluated and means to study and evaluate new trends in data storage management have to be provided. This article proposes a benchmark for combined OLTP and operational reporting, providing means to evaluate the performance of enterprise data management systems for mixed workloads of OLTP and operational reporting queries. Such systems offer up-to-date information and the flexibility of the entire data set for reporting. We describe how the benchmark provokes the conflicts that are the reason for separating the two workloads on different systems. In this article, we introduce the concepts, logical data schema, transactions and queries of the benchmark, which are entirely based on the original data sets and real workloads of existing, globally operating enterprises.
KW  - Benchmarking
KW  - Mixed workload
KW  - OLTP
KW  - Operational reporting
Y1  - 2011
U6  - https://doi.org/10.1007/s10796-010-9283-8
SN  - 1387-3326
VL  - 13
IS  - 3
SP  - 321
EP  - 335
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Boix, Carme
A1  - Frijia, Gianluca
A1  - Vicedo, Vicent
A1  - Bernaus, Josep M.
A1  - Di Lucia, Matteo
A1  - Parente, Mariano
A1  - Caus, Esmeralda
T1  - Larger foraminifera distribution and strontium isotope stratigraphy of the La Cova limestones (Coniacian-Santonian, "Serra del Montsec", Pyrenees, NE Spain)
JF  - Cretaceous research
N2  - The Upper Cretaceous La Cova limestones (southern Pyrenees, Spain) host a rich and diverse larger foraminiferal fauna, which represents the first diversification of K-strategists after the mass extinction at the Cenomanian-Turonian boundary.
 The stratigraphic distribution of the main taxa of larger foraminifera defines two assemblages. The first assemblage is characterised by the first appearance of lacazinids (Pseudolacazina loeblichi) and mean-dropsinids (Eofallotia simplex), by the large agglutinated Montsechiana montsechiensis, and by several species of complex rotalids (Rotorbinella campaniola, Iberorotalia reicheli, Orbitokhatina wondersmitti and Calcarinella schaubi). The second assemblage is defined by the appearance of Lacazina pyrenaica, Palandrosina taxyae and Martiguesia cyclamminiformis.
 A late Coniacian-early Santonian age was so far accepted for the La Cova limestones, based on indirect correlation with deep-water fades bearing planktic foraminifers of the Dicarinella concavata zone. Strontium isotope stratigraphy, based on many samples of pristine biotic calcite of rudists and ostreids, indicates that the La Cova limestones span from the early Coniacian to the early-middle Santonian boundary. The first assemblage of larger foraminifera appears very close to the early-middle Coniacian boundary and reaches its full diversity by the middle Coniacian. The originations defining the second assemblage are dated as earliest Santonian: they represent important bioevents to define the Coniacian-Santonian boundary in the shallow-water facies of the South Pyrenean province.
 By means of the calibration of strontium isotope stratigraphy to the Geological Time Scale, the larger foraminiferal assemblages of the La Cova limestones can be correlated to the standard biozonal scheme of ammonites, planktonic foraminifers and calcareous nannoplankton. This correlation is a first step toward a larger foraminifera standard biozonation for Upper Cretaceous carbonate platform facies.
KW  - Larger Foraminifera
KW  - Biostratigraphy
KW  - Strontium isotope stratigraphy
KW  - Coniacian-Santonian boundary
KW  - Shallow-water carbonates
KW  - Pyrenees
KW  - Spain
Y1  - 2011
U6  - https://doi.org/10.1016/j.cretres.2011.05.009
SN  - 0195-6671
VL  - 32
IS  - 6
SP  - 806
EP  - 822
PB  - Elsevier
CY  - London
ER  - 
TY  - JOUR
A1  - Bonaventura, Klaus
A1  - Sonntag, Steffen
A1  - Kleber, Franz X.
T1  - Antiplatelet therapy in the era of percutaneous coronary intervention with drug-eluting balloons
JF  - EuroIntervention : official journal of EuroPCR and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)
N2  - The high rate of restenosis associated with percutaneous coronary intervention (PCI) procedures can be reduced with the implantation of metallic stents into the stenotic vessels. The knowledge that neointimal formation can result in restenosis after stent implantation led to the development of drug-eluting stents (DES) which require long lasting antiplatelet therapy to avoid thrombotic complications. In the last years, the drug-eluting balloon (DEB) technology has emerged as an alternative option for the treatment of coronary and peripheral arteries. Clinical studies demonstrated the safety and effectiveness of DEB in various clinical scenarios and support the use of paclitaxel-eluting balloons for the treatment of in-stent restenosis, of small coronary arteries and bifurcations lesions. The protocols of DEB studies suggest that the dual antiplatelet therapy with aspirin and clopidogrel of four weeks after DEB is safe and effective.
KW  - drug-eluting balloon
KW  - clopidogrel
KW  - drug-eluting stent
KW  - coronary artery disease
Y1  - 2011
SN  - 1774-024X
VL  - 7
IS  - 2
SP  - K106
EP  - K111
PB  - Universitätsverlag Potsdam
CY  - Toulouse
ER  -