TY  - GEN
A1  - Ponce, Carol Barahona
A1  - Scherer, Dominique
A1  - Boekstegers, Felix
A1  - Garate-Calderon, Valentina
A1  - Jenab, Mazda
A1  - Aleksandrova, Krasimira
A1  - Katzke, Verena
A1  - Weiderpass, Elisabete
A1  - Bonet, Catalina
A1  - Moradi, Tahereh
A1  - Fischer, Krista
A1  - Bossers, Willem
A1  - Brenner, Hermann
A1  - Schöttker, Ben
A1  - Holleczek, Bernd
A1  - Hveem, Kristian
A1  - Eklund, Niina
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Bermejo, Justo Lorenzo
T1  - Arsenic and gallbladder cancer risk
BT  - Mendelian randomization analysis of European prospective data
T2  - International journal of cancer
KW  - arsenic
KW  - gallbladder cancer
KW  - Mendelian randomization
Y1  - 2019
U6  - https://doi.org/10.1002/ijc.32837
SN  - 0020-7136
SN  - 1097-0215
VL  - 146
IS  - 9
SP  - 2648
EP  - 2650
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Zeiher, Johannes
A1  - Duch, M.
A1  - Kroll, Lars Eric
A1  - Mensink, Gerhardus Bernardus Maria
A1  - Finger, Jonas David
A1  - Keil, Thomas
T1  - Domain-specific physical activity patterns and cardiorespiratory fitness among adults in Germany
T2  - The European Journal of Public Health
N2  - Background Studies show that occupational physical activity (OPA) has less health-enhancing effects than leisure-time physical activity (LTPA). The spare data available suggests that OPA rarely includes aerobic PAs with little or no enhancing effects on cardiorespiratory fitness (CRF) as a possible explanation. This study aims to investigate the associations between patterns of OPA and LTPA and CRF among adults in Germany. Methods 1,204 men and 1,303 women (18-64 years), who participated in the German Health Interview and Examination Survey 2008-2011, completed a standardized sub-maximal cycle ergometer test to estimate maximal oxygen consumption (VO2max). Job positions were coded according to the level of physical effort to construct an occupational PA index and categorized as low vs. high OPA. LTPA was assessed via questionnaires and dichotomized in no vs. any LTPA participation. A combined LTPA/OPA variable was used (high OPA/ LTPA, low OPA/LTPA, high OPA/no LTPA, low OPA/no LTPA). Information on potential confounders was obtained via questionnaires (e.g., smoking and education) or physical measurements (e.g., waist circumference). Multi-variable logistic regression was used to analyze associations between OPA/LTPA patterns and VO2max. Results Preliminary analyses showed that less-active men were more likely to have a low VO2max with odds ratios (ORs) of 0.80 for low OPA/LTPA, 1.84 for high OPA/no LTPA and 3.46 for low OPA/no LTPA compared to high OPA/LTPA. The corresponding ORs for women were 1.11 for low OPA/LTPA, 3.99 for high OPA/no LTPA and 2.44 for low OPA/no LTPA, indicating the highest likelihood of low fitness for women working in physically demanding jobs and not engaging in LTPA. Conclusions Findings confirm a strong association between LTPA and CRF and suggest an interaction between OPA and LTPA patterns on CRF within the workforce in Germany. Women without LTPA are at high risk of having a low CRF, especially if they work in physically demanding jobs. Key messages Women not practicing leisure-time physical activity are at risk of having a low cardiorespiratory fitness, especially if they work in physically demanding jobs. Different impact of domains of physical activity should be considered when planning interventions to enhance fitness among the adult population.
Y1  - 2019
SN  - 1101-1262
SN  - 1464-360X
VL  - 29
IS  - Supplement. 4
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - GEN
A1  - Plank, Roswitha
A1  - Yealland, Guy
A1  - Miceli, Enrico
A1  - Cunha, Dulce Lima
A1  - Graff, Patrick
A1  - Thomforde, Sari
A1  - Gruber, Robert
A1  - Moosbrugger-Martinz, Verena
A1  - Eckl, Katja
A1  - Calderon, Marcelo
A1  - Hennies, Hans Christian
A1  - Hedtrich, Sarah
T1  - Transglutaminase 1 Replacement Therapy Successfully Mitigates the Autosomal Recessive Congenital Ichthyosis Phenotype in Full-Thickness Skin Disease Equivalents
T2  - The journal of investigative dermatology
Y1  - 2019
U6  - https://doi.org/10.1016/j.jid.2018.11.002
SN  - 0022-202X
SN  - 1523-1747
VL  - 139
IS  - 5
SP  - 1191
EP  - 1195
PB  - Elsevier
CY  - New York
ER  - 
TY  - GEN
A1  - Wellenberg, Anna
A1  - Weides, L.
A1  - Bornhorst, Julia
A1  - Crone, Barbara
A1  - Karst, U.
A1  - Fritz, G.
A1  - Honnen, S.
T1  - Molecular and electrophysiological analysis of platinum-induced neurotoxicity using the model organism C. elegans
T2  - Naunyn-Schmiedeberg's archives of pharmacology
Y1  - 2019
UR  - https://link.springer.com/content/pdf/10.1007%2Fs00210-019-01621-6.pdf
U6  - https://doi.org/10.1007/s00210-019-01621-6
SN  - 0028-1298
SN  - 1432-1912
VL  - 392
SP  - S63
EP  - S63
PB  - Springer
CY  - New York
ER  -