TY  - JOUR
A1  - Wittenbecher, Clemens
A1  - Kuxhaus, Olga
A1  - Boeing, Heiner
A1  - Stefan, Norbert
A1  - Schulze, Matthias Bernd
T1  - Associations of short stature and components of height with incidence of type 2 diabetes
BT  - mediating effects of cardiometabolic risk factors
JF  - Diabetologia : journal of the European Association for the Study of Diabetes (EASD)
N2  - Aims/hypothesis This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. Methods A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. Results After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. Conclusions/interpretation We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile.
KW  - Adult height
KW  - Blood pressure
KW  - Diabetes incidence
KW  - Leg length
KW  - Liver fat
KW  - Short stature
KW  - Trunk length
Y1  - 2019
U6  - https://doi.org/10.1007/s00125-019-04978-8
SN  - 0012-186X
SN  - 1432-0428
VL  - 62
IS  - 12
SP  - 2211
EP  - 2221
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Wittenbecher, Clemens
A1  - Ouni, Meriem
A1  - Kuxhaus, Olga
A1  - Jähnert, Markus
A1  - Gottmann, Pascal
A1  - Teichmann, Andrea
A1  - Meidtner, Karina
A1  - Kriebel, Jennifer
A1  - Grallert, Harald
A1  - Pischon, Tobias
A1  - Boeing, Heiner
A1  - Schulze, Matthias Bernd
A1  - Schürmann, Annette
T1  - Insulin-Like Growth Factor Binding Protein 2 (IGFBP-2) and the Risk of Developing Type 2 Diabetes
JF  - Diabetes : a journal of the American Diabetes Association
N2  - Recent studies suggest that insulin-like growth factor binding protein 2 (IGFBP-2) may protect against type 2 diabetes, but population-based human studies are scarce. We aimed to investigate the prospective association of circulating IGFBP-2 concentrations and of differential methylation in the IGFBP-2 gene with type 2 diabetes risk.
Y1  - 2019
U6  - https://doi.org/10.2337/db18-0620
SN  - 0012-1797
SN  - 1939-327X
VL  - 68
IS  - 1
SP  - 188
EP  - 197
PB  - American Diabetes Association
CY  - Alexandria
ER  - 
TY  - JOUR
A1  - Eichelmann, Fabian
A1  - Schulze, Matthias Bernd
A1  - Wittenbecher, Clemens
A1  - Menzel, Juliane
A1  - Weikert, Cornelia
A1  - di Giuseppe, Romina
A1  - Biemann, Ronald
A1  - Isermann, Berend
A1  - Fritsche, Andreas
A1  - Boeing, Heiner
A1  - Aleksandrova, Krasimira
T1  - Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer
JF  - JAMA network open
N2  - IMPORTANCE Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. OBJECTIVE To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. DESIGN, SETTING, AND PARTICIPANTS Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. MAIN OUTCOMES AND MEASURES Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. CONCLUSIONS AND RELEVANCE This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis.
Y1  - 2019
U6  - https://doi.org/10.1001/jamanetworkopen.2019.0896
SN  - 2574-3805
VL  - 2
IS  - 3
PB  - American Veterinary Medical Association
CY  - Chicago
ER  -