TY  - JOUR
A1  - Duydu, Yalcin
A1  - Basaran, Nursen
A1  - Ustundag, Aylin
A1  - Aydin, Sevtap
A1  - Yalcin, Can Ozgur
A1  - Anlar, Hatice Gul
A1  - Bacanli, Merve
A1  - Aydos, Kaan
A1  - Atabekoglu, Cem Somer
A1  - Golka, Klaus
A1  - Ickstadt, Katja
A1  - Schwerdtle, Tanja
A1  - Werner, Matthias
A1  - Meyer, Sören
A1  - Bolt, Hermann M.
T1  - Birth weights of newborns and pregnancy outcomes of environmentally boron-exposed females in Turkey
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By contrast, studies on boron-mediated developmental effects in females are scarce. The present study was designed to fill this gap. Hundred and ninety nine females residing in Bandirma and Bigadic participated in this study investigating pregnancy outcomes. The participants constituted a study group covering blood boron from low (< 100 ng B/g blood, n = 143) to high (> 150 ng B/g blood, n = 27) concentrations. The mean blood boron concentration and the mean estimated daily boron exposure of the high exposure group was 274.58 (151.81-975.66) ng B/g blood and 24.67 (10.47-57.86) mg B/day, respectively. In spite of the high level of daily boron exposure, boron-mediated adverse effects on induced abortion, spontaneous abortion (miscarriage), stillbirth, infant death, neonatal death, early neonatal death, preterm birth, congenital anomalies, sex ratio and birth weight of newborns were not observed.
KW  - Boric acid
KW  - Boron exposure
KW  - Biological monitoring
KW  - Developmental toxicity
KW  - Pregnancy outcomes
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2238-4
SN  - 0340-5761
SN  - 1432-0738
VL  - 92
IS  - 8
SP  - 2475
EP  - 2485
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Duydu, Yalcin
A1  - Basaran, Nursen
A1  - Aydin, Sevtap
A1  - Ustundag, Aylin
A1  - Yalcin, Can Özgür
A1  - Anlar, Hatice Gul
A1  - Bacanli, Merve
A1  - Aydos, Kaan
A1  - Atabekoglu, Cem Somer
A1  - Golka, Klaus
A1  - Ickstadt, Katja
A1  - Schwerdtle, Tanja
A1  - Werner, Matthias
A1  - Meyer, Sören
A1  - Bolt, Hermann M.
T1  - Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated toxic effects. As validation by another independent study is still required, the present study has investigated possible boron-associated effects on male reproduction in workers (n = 212) under different boron exposure conditions. The mean daily boron exposure (DBE) and blood boron concentration of workers in the extreme exposure group (n = 98) were 47.17 +/- 17.47 (7.95-106.8) mg B/day and 570.6 +/- 160.1 (402.6-1100) ng B/g blood, respectively. Nevertheless, boron-associated adverse effects on semen parameters, as well as on FSH, LH and total testosterone levels were not seen, even within the extreme exposure group. With this study, a total body of evidence has accumulated that allows to conclude that male reproductive effects are not relevant to humans, under any feasible and realistic conditions of exposure to inorganic boron compounds.
KW  - Boron exposure
KW  - Boric acid
KW  - Reproductive toxicity
KW  - FSH
KW  - LH
KW  - Testosterone
KW  - Semen parameters
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2296-7
SN  - 0340-5761
SN  - 1432-0738
VL  - 92
IS  - 10
SP  - 3051
EP  - 3059
PB  - Springer
CY  - Heidelberg
ER  -