TY  - JOUR
A1  - Tejos, Ricardo
A1  - Rodriguez-Furlan, Cecilia
A1  - Adamowski, Maciej
A1  - Sauer, Michael
A1  - Norambuena, Lorena
A1  - Friml, Jiri
T1  - PATELLINS are regulators of auxin-mediated PIN1 relocation and plant development in Arabidopsis thaliana
JF  - Journal of cell science
N2  - Coordinated cell polarization in developing tissues is a recurrent theme in multicellular organisms. In plants, a directional distribution of the plant hormone auxin is at the core of many developmental programs. A feedback regulation of auxin on the polarized localization of PIN auxin transporters in individual cells has been proposed as a self-organizing mechanism for coordinated tissue polarization, but the molecular mechanisms linking auxin signalling to PIN-dependent auxin transport remain unknown. We used a microarray-based approach to find regulators of the auxin-induced PIN relocation in Arabidopsis thaliana root, and identified a subset of a family of phosphatidylinositol transfer proteins (PITPs), the PATELLINs (PATLs). Here, we show that PATLs are expressed in partially overlapping cell types in different tissues going through mitosis or initiating differentiation programs. PATLs are plasma membrane-associated proteins accumulated in Arabidopsis embryos, primary roots, lateral root primordia and developing stomata. Higher order patl mutants display reduced PIN1 repolarization in response to auxin, shorter root apical meristem, and drastic defects in embryo and seedling development. This suggests that PATLs play a redundant and crucial role in polarity and patterning in Arabidopsis.
KW  - PATELLIN
KW  - Auxin
KW  - Arabidopsis thaliana
KW  - Auxin transport
KW  - Canalization
Y1  - 2018
U6  - https://doi.org/10.1242/jcs.204198
SN  - 0021-9533
SN  - 1477-9137
VL  - 131
IS  - 2
PB  - Company of Biologists Limited
CY  - Cambridge
ER  -