TY - JOUR A1 - Goethe, Katrin A1 - Esser, Günter A1 - Gendt, Anja A1 - Kliegl, Reinhold T1 - Working memory in children tracing age differences and special educational needs to parameters of a formal model JF - Developmental psychology N2 - Parameters of a formal working-memory model were estimated for verbal and spatial memory updating of children. The model proposes interference though feature overwriting and through confusion of whole elements as the primary cause of working-memory capacity limits. We tested 2 age groups each containing 1 group of normal intelligence and I deficit group. For young children the deficit was developmental dyslexia; for older children it was a general learning difficulty. The interference model predicts less interference through overwriting but more through confusion of whole elements for the dyslexic children than for their age-matched controls. Older children exhibited less interference through confusion of whole elements and a higher processing rate than young children, but general learning difficulty was associated with slower processing than in the age-matched control group. Furthermore, the difference between verbal and spatial updating mapped onto several meaningful dissociations of model parameters. KW - working-memory capacity KW - interference model KW - dyslexia KW - general learning difficulty Y1 - 2012 U6 - https://doi.org/10.1037/a0025660 SN - 0012-1649 VL - 48 IS - 2 SP - 459 EP - 476 PB - American Psychological Association CY - Washington ER - TY - JOUR A1 - Laucht, Manfred A1 - Blomeyer, Dorothea A1 - Buchmann, Arlette F. A1 - Treutlein, Jens A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Jennen-Steinmetz, Christine A1 - Rietschel, Marcella A1 - Zimmermann, Ulrich S. A1 - Banaschewski, Tobias T1 - Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis JF - The journal of child psychology and psychiatry N2 - Background: Recently, first evidence has been reported for a geneparenting interaction (G x E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G x E would be consistent with one of two models of geneenvironment interplay (genetic vulnerability vs. differential susceptibility). Methods: Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val(158) Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results: Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions: The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. KW - Catechol-O-methyltransferase gene KW - alcohol use KW - adolescents KW - parenting KW - gene-environment interaction Y1 - 2012 U6 - https://doi.org/10.1111/j.1469-7610.2011.02408.x SN - 0021-9630 VL - 53 IS - 4 SP - 351 EP - 359 PB - Wiley-Blackwell CY - Malden ER - TY - JOUR A1 - Hohmann, S. A1 - Buchmann, Arlette F. A1 - Witt, S. H. A1 - Rietschel, M. A1 - Jennen-Steinmetz, Christine A1 - Schmidt, M. H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development JF - Pediatric obesity N2 - Objective: To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood. Design: Longitudinal, prospective study of a German community sample. Subjects: n = 306 young adults (139 males, 167 females). Measurements: Participants' body weight and height were assessed at the ages of 3 months and 2, 4.5, 8, 11, 15 and 19 years. NPY rs16147 was genotyped. Results: Controlling for a number of possible confounders, homozygote carriers of the rs16147 C allele exhibited significantly lower BMI scores when compared with individuals carrying the T allele. In addition, a significant genotype by age interaction emerged, indicating that the genotype effect increased during the course of development. Conclusions: This is the first longitudinal study to report an association between rs16147 and BMI during childhood and adolescence. The finding that this effect increased during the course of development may either be due to age-dependent alterations in gene expression or to maturation processes within the weight regulation circuits of the central nervous system. KW - Development KW - neuropeptide Y KW - rs16147 KW - weight regulation Y1 - 2012 U6 - https://doi.org/10.1111/j.2047-6310.2012.00069.x SN - 2047-6310 VL - 7 IS - 6 SP - 453 EP - 460 PB - Wiley-Blackwell CY - Hoboken ER - TY - BOOK A1 - Esser, Günter A1 - Wyschkon, Anne T1 - Basisdiagnostik umschriebener Entwicklungsstörungen im Vorschulalter : (BUEVA) Version II BT - BUEVA Y1 - 2012 PB - Beltz CY - Göttingen ER - TY - JOUR A1 - Kucian, Karin A1 - Kohn, Juliane A1 - Hannula-Sormunen, Minna M. A1 - Richtmann, Verena A1 - Grond, Ursin A1 - Käser, Tanja A1 - Esser, Günter A1 - von Aster, Michael G. T1 - Kinder mit Dyskalkulie fokussieren spontan weniger auf Anzahligkeit Y1 - 2012 ER - TY - BOOK A1 - Ihle, Wolfgang A1 - Groen, Gunter A1 - Walter, Daniel A1 - Esser, Günter A1 - Petermann, Franz T1 - Depression T3 - Leitfaden Kinder- und Jugendpsychotherapie Y1 - 2012 SN - 978-3-8017-2381-1 VL - 16 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Daig, Isolde A1 - Mahlberg, Richard A1 - Stethin, Julia A1 - Shroeder, Franziska A1 - Wrase, Jana A1 - Knoll, Nina A1 - Bschor, Tom A1 - Esser, Günter A1 - Heinz, Andreas A1 - Kienast, Thorsten T1 - Decreased verbal learning but not recognition performance in alcohol-dependent individuals during early abstinence Y1 - 2012 ER - TY - GEN A1 - Laucht, Manfred A1 - Blomeyer, Dorothea A1 - Buchmann, Arlette F. A1 - Treutlein, Jens A1 - Shmidt, Martin H. A1 - Esser, Günter A1 - Jennen-Steinmetz, Christine A1 - Rietschel, Marcella A1 - Zimmermann, Ulrich S. A1 - Banaschewski, Tobias T1 - Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis Y1 - 2012 ER - TY - JOUR A1 - Laucht, Manfred A1 - Treutlein, Jens A1 - Blomeyer, Dorothea A1 - Buchmann, Arlette F. A1 - Schmidt, Martin A1 - Esser, Günter A1 - Jennen-Steinmetz, Christine A1 - Reitschelb, Marcel A1 - Banaschewski, Tobias T1 - Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: Findings from a longitudinal study Y1 - 2012 ER - TY - JOUR A1 - Göthe, Katrin A1 - Esser, Günter A1 - Gendt, Anja A1 - Kliegl, Reinhold T1 - Working memory in children : tracing age differences and special educational needs to parameters of a formal model N2 - Parameters of a formal working-memory model were estimated for verbal and spatial memory updating of children. The model proposes interference though feature overwriting and through confusion of whole elements as the primary cause of working-memory capacity limits. We tested 2 age groups each containing 1 group of normal intelligence and 1 deficit group. For young children the deficit was developmental dyslexia; for older children it was a general learning difficulty. The interference model predicts less interference through overwriting but more through confusion of whole elements for the dyslexic children than for their age-matched controls. Older children exhibited less interference through confusion of whole elements and a higher processing rate than young children, but general learning difficulty was associated with slower processing than in the age-matched control group. Furthermore, the difference between verbal and spatial updating mapped onto several meaningful dissociations of model parameters. Y1 - 2012 ER -