TY - JOUR A1 - Jannasch, Franziska A1 - Kröger, Janine A1 - Agnoli, Claudia A1 - Barricarte, Aurelio A1 - Boeing, Heiner A1 - Cayssials, Valérie A1 - Colorado-Yohar, Sandra A1 - Dahm, Christina C. A1 - Dow, Courtney A1 - Fagherazzi, Guy A1 - Franks, Paul W. A1 - Freisling, Heinz A1 - Gunter, Marc J. A1 - Kerrison, Nicola D. A1 - Key, Timothy J. A1 - Khaw, Kay-Tee A1 - Kühn, Tilman A1 - Kyro, Cecilie A1 - Mancini, Francesca Romana A1 - Mokoroa, Olatz A1 - Nilsson, Peter A1 - Overvad, Kim A1 - Palli, Domenico A1 - Panico, Salvatore A1 - Quiros Garcia, Jose Ramon A1 - Rolandsson, Olov A1 - Sacerdote, Carlotta A1 - Sanchez, Maria-Jose A1 - Sahrai, Mohammad Sediq A1 - Schübel, Ruth A1 - Sluijs, Ivonne A1 - Spijkerman, Annemieke M. W. A1 - Tjonneland, Anne A1 - Tong, Tammy Y. N. A1 - Tumino, Rosario A1 - Riboli, Elio A1 - Langenberg, Claudia A1 - Sharp, Stephen J. A1 - Forouhi, Nita G. A1 - Schulze, Matthias Bernd A1 - Wareham, Nicholas J. T1 - Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations JF - The Journal of Nutrition N2 - Background: Population-specificity of exploratory dietary patterns limits their generalizability in investigations with type 2 diabetes incidence. Objective: The aim of this study was to derive country-specific exploratory dietary patterns, investigate their association with type 2 diabetes incidence, and replicate diabetes-associated dietary patterns in other countries. Methods: Dietary intake data were used, assessed by country-specific questionnaires at baseline of 11,183 incident diabetes cases and 14,694 subcohort members (mean age 52.9 y) from 8 countries, nested within the European Prospective Investigation into Cancer and Nutrition study (mean follow-up time 6.9 y). Exploratory dietary patterns were derived by principal component analysis. HRs for incident type 2 diabetes were calculated by Prentice-weighted Cox proportional hazard regression models. Diabetes-associated dietary patterns were simplified or replicated to be applicable in other countries. A meta-analysis across all countries evaluated the generalizability of the diabetes-association. Results: Two dietary patterns per country/UK-center, of which overall 3 dietary patterns were diabetes-associated, were identified. A risk-lowering French dietary pattern was not confirmed across other countries: pooled HRFrance per 1 SD: 1.00; 95% CI: 0.90, 1.10. Risk-increasing dietary patterns, derived in Spain and UK-Norfolk, were confirmed, but only the latter statistically significantly: HRSpain: 1.09; 95% CI: 0.97, 1.22 and HRUK-Norfolk: 1.12; 95% CI: 1.04, 1.20. Respectively, this dietary pattern was characterized by relatively high intakes of potatoes, processed meat, vegetable oils, sugar, cake and cookies, and tea. Conclusions: Only few country/center-specific dietary patterns (3 of 18) were statistically significantly associated with diabetes incidence in this multicountry European study population. One pattern, whose association with diabetes was confirmed across other countries, showed overlaps in the food groups potatoes and processed meat with identified diabetes-associated dietary patterns from other studies. The study demonstrates that replication of associations of exploratory patterns with health outcomes is feasible and a necessary step to overcome population-specificity in associations from such analyses. KW - dietary patterns KW - principal component analysis KW - diet-disease association KW - type 2 diabetes mellitus KW - replication KW - meta-analysis Y1 - 2019 U6 - https://doi.org/10.1093/jn/nxz031 SN - 0022-3166 SN - 1541-6100 VL - 149 IS - 6 SP - 1047 EP - 1055 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Saberi Hosnijeh, Fatemeh A1 - Casabonne, Delphine A1 - Nieters, Alexandra A1 - Solans, Marta A1 - Naudin, Sabine A1 - Ferrari, Pietro A1 - Mckay, James D. A1 - Benavente, Yolanda A1 - Weiderpass, Elisabete A1 - Freisling, Heinz A1 - Severi, Gianluca A1 - Boutron Ruault, Marie-Christine A1 - Besson, Caroline A1 - Agnoli, Claudia A1 - Masala, Giovanna A1 - Sacerdote, Carlotta A1 - Tumino, Rosario A1 - Huerta, Jose Maria A1 - Amiano, Pilar A1 - Rodriguez-Barranco, Miguel A1 - Bonet, Catalina A1 - Barricarte, Aurelio A1 - Christakoudi, Sofia A1 - Knuppel, Anika A1 - Bueno-de-Mesquita, Bas A1 - Schulze, Matthias Bernd A1 - Kaaks, Rudolf A1 - Canzian, Federico A1 - Spath, Florentin A1 - Jerkeman, Mats A1 - Rylander, Charlotta A1 - Tjonneland, Anne A1 - Olsen, Anja A1 - Borch, Kristin Benjaminsen A1 - Vermeulen, Roel T1 - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma BT - an exposome-wide analysis JF - International journal of cancer N2 - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL. KW - exposome KW - exposome‐ wide association study KW - lifestyle KW - lymphoma KW - prospective study Y1 - 2020 U6 - https://doi.org/10.1002/ijc.33369 SN - 0020-7136 SN - 1097-0215 VL - 148 IS - 9 SP - 2115 EP - 2128 PB - Wiley CY - Hoboken ER - TY - GEN A1 - Saberi Hosnijeh, Fatemeh A1 - Casabonne, Delphine A1 - Nieters, Alexandra A1 - Solans, Marta A1 - Naudin, Sabine A1 - Ferrari, Pietro A1 - Mckay, James D. A1 - Benavente, Yolanda A1 - Weiderpass, Elisabete A1 - Freisling, Heinz A1 - Severi, Gianluca A1 - Boutron Ruault, Marie-Christine A1 - Besson, Caroline A1 - Agnoli, Claudia A1 - Masala, Giovanna A1 - Sacerdote, Carlotta A1 - Tumino, Rosario A1 - Huerta, Jose Maria A1 - Amiano, Pilar A1 - Rodriguez-Barranco, Miguel A1 - Bonet, Catalina A1 - Barricarte, Aurelio A1 - Christakoudi, Sofia A1 - Knuppel, Anika A1 - Bueno-de-Mesquita, Bas A1 - Schulze, Matthias Bernd A1 - Kaaks, Rudolf A1 - Canzian, Federico A1 - Spath, Florentin A1 - Jerkeman, Mats A1 - Rylander, Charlotta A1 - Tjonneland, Anne A1 - Olsen, Anja A1 - Borch, Kristin Benjaminsen A1 - Vermeulen, Roel T1 - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma BT - an exposome-wide analysis T2 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1374 KW - exposome KW - exposome‐ wide association study KW - lifestyle KW - lymphoma KW - prospective study Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-573562 SN - 1866-8372 IS - 9 ER -