TY  - JOUR
A1  - Ette, Ottmar
T1  - Anton Wilhelm Amo
BT  - eine Aufklärung zwischen Afrika und Europa
JF  - Alexandria dein Magazin für Wissenschaft
Y1  - 2020
UR  - https://www.alexandria-magazin.at/
IS  - 1
SP  - 17
EP  - 21
PB  - Verein für Wissenschaftskommunikation und zur Förderung von Wissenschaftler_Innen
CY  - Wien
ER  - 
TY  - JOUR
A1  - Wagner, Rolf
T1  - Anwendbares Recht für zivilrechtliche Schadensersatzansprüche aufgrund von Virusinfektionen
JF  - COVID-19 und alle Rechtsfragen zur Corona-Krise
N2  - In dieser Zeitschrift ist bereits darauf hingewiesen worden, dass eine Person, die mit dem Sars-CoV-2-Virus infiziert worden ist, in bestimmten Fällen daran denken kann, gegen die Person, die sie infiziert hat, oder gegen eine andere Person einen zivilrechtlichen Schadensersatzanspruch geltend zu machen. zur Fussnote 1 Derartige Schadensersatzansprüche können sich aus der Nichtbeachtung von Hygiene-, Abstands- und Quarantäneregelungen sowie von Regelungen zum Mund- und Nasenschutz ergeben. Im Vorbericht zur Fussnote 2 ist bereits geklärt worden, welche Gerichte anzurufen sind, wenn der Sachverhalt eine Auslandsberührung aufweist. Mit der Bestimmung des international zuständigen Gerichts hat es in diesen Sachverhalten aber nicht schon sein Bewenden. Denn wenn das zuständige Gericht feststeht, darf dieses nicht sogleich prüfen, ob der geltend gemachte Schadensersatzanspruch besteht. Vielmehr muss es in Sachverhalten mit Auslandsberührung erst einmal ermitteln, welches Recht auf den Schadensersatzanspruch anwendbar ist. Der folgende Beitrag widmet sich dieser Frage. Die Ausführungen sind nicht nur für die Geltendmachung von Schadensersatzansprüchen aufgrund Infektionen mit dem Sars-CoV-2-Virus von Nutzen, sondern auch dann, wenn zukünftig zivilrechtliche Schadensersatzansprüche aufgrund Infektionen mit anderen, ggfs. auch neu auftretenden, Viren geltend gemacht werden sollen.
Y1  - 2020
UR  - https://beck-online.beck.de/Bcid/Y-300-Z-COVUR-B-2020-S-738-N-1
SN  - 2700-3051
VL  - 1
IS  - 14
SP  - 738
EP  - 742
PB  - C.H. Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Ziemann, Martin Andreas
A1  - Madariaga, Juan Manuel
T1  - Applications of Raman spectroscopy in art and archaeology
JF  - Journal of Raman spectroscopy
N2  - The 10th edition of the International Congress on the Application of Raman Spectroscopy in Art and Archaeology (RAA2019) was held in Potsdam (Germany) from 3 to 7 September 2019, with eight keynote lectures, 35 oral presentations and 18 Poster Presentations. The number of active participants was 68 delegates from 20 countries among the 236 authors that presented at least one work.
Y1  - 2020
U6  - https://doi.org/10.1002/jrs.6054
SN  - 0377-0486
SN  - 1097-4555
VL  - 52
IS  - 1
SP  - 8
EP  - 14
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Olen, Stephanie M.
A1  - Bookhagen, Bodo
T1  - Applications of SAR interferometric coherence time series
BT  - satiotemporal dynamics of geomorphic transitions in the South-Central Andes
JF  - Journal of geophysical research : Earth surface
N2  - Sediment transport domains in mountain landscapes are characterized by fundamentally different processes and rates depending on several factors, including geology, climate, and biota. Accurately identifying where transitions between transport domains occur is an important step to quantify the past, present, and future contribution of varying erosion and sedimentation processes and enhance our predictive capabilities. We propose a new methodology based on time series of synthetic aperture radar (SAR) interferometric coherence images to map sediment transport regimes across arid and semiarid landscapes. Using 4 years of Sentinel-1 data, we analyze sediment transport regimes for the south-central Andes in northwestern Argentina characterized by steep topographic and climatic gradients. We observe seasonally low coherence during the regional wet season, particularly on hillslopes and in alluvial channels. The spatial distribution of coherence is compared to drainage areas extracted from digital topography to identify two distinct transitions within watersheds: (a) a hillslope-to-fluvial and (b) a fluvial-to-alluvial transition. While transitions within a given basin can be well-constrained, the relative role of each sediment transport domain varies widely over the climatic and topographic gradients. In semiarid regions, we observe larger relative contributions from hillslopes compared to arid regions. Across regional gradients, the range of coherence within basins positively correlates to previously published millennial catchment-wide erosion rates and to topographic metrics used to indicate long-term uplift. Our study suggests that a dense time series of interferometric coherence can be used as a proxy for surface sediment movement and landscape stability in vegetation-free settings at event to decadal timescales.
KW  - Copernicus
KW  - SAR
KW  - critical infrastructure resilience
KW  - early warning
KW  - landslides
Y1  - 2020
U6  - https://doi.org/10.1029/2019JF005141
SN  - 2169-9003
SN  - 2169-9011
VL  - 125
IS  - 3
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Ziebarth, Malte J.
A1  - von Specht, Sebastian
A1  - Heidbach, Oliver
A1  - Cotton, Fabrice
A1  - Anderson, John G.
T1  - Applying conservation of energy to estimate earthquake frequencies from strain rates and stresses
JF  - Journal of geophysical research : Solid earth
N2  - Estimating earthquake occurrence rates from the accumulation rate of seismic moment is an established tool of seismic hazard analysis. We propose an alternative, fault-agnostic approach based on the conservation of energy: the Energy-Conserving Seismicity Framework (ENCOS). Working in energy space has the advantage that the radiated energy is a better predictor of the damage potential of earthquake waves than the seismic moment release. In a region, ENCOS balances the stationary power available to cause earthquakes with the long-term seismic energy release represented by the energy-frequency distribution's first moment. Accumulation and release are connected through the average seismic efficiency, by which we mean the fraction of released energy that is converted into seismic waves. Besides measuring earthquakes in energy, ENCOS differs from moment balance essentially in that the energy accumulation rate depends on the total stress in addition to the strain rate tensor. To validate ENCOS, we exemplarily model the energy-frequency distribution around Southern California. We estimate the energy accumulation rate due to tectonic loading assuming poroelasticity and hydrostasis. Using data from the World Stress Map and assuming the frictional limit to estimate the stress tensor, we obtain a power of 0.8 GW. The uncertainty range, 0.3-2.0GW, originates mainly from the thickness of the seismogenic crust, the friction coefficient on preexisting faults, and models of Global Positioning System (GPS) derived strain rates. Based on a Gutenberg-Richter magnitude-frequency distribution, this power can be distributed over a range of energies consistent with historical earthquake rates and reasonable bounds on the seismic efficiency.
Y1  - 2020
U6  - https://doi.org/10.1029/2020JB020186
SN  - 2169-9313
SN  - 2169-9356
VL  - 125
IS  - 8
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - von Steinau-Steinrück, Robert
A1  - Jöris, Nils
T1  - Arbeitsschutz bei Corona
BT  - Versuch einer Entwirrung
JF  - NJW spezial
N2  - Den Überblick im Arbeitsschutzrecht zu behalten, ist schwierig. Der Arbeitsschutz spielt sich in unterschiedlichen Bereichen und auf verschiedenen Ebenen ab. Außerdem sind die einschlägigen Rechtsnormen überaus verästelt. Der folgende Beitrag soll daher zur Entwirrung beitragen.
Y1  - 2020
UR  - https://beck-online.beck.de/Bcid/Y-300-Z-NJW-SPEZIAL-B-2020-S-370-N-1
SN  - 1613-4621
VL  - 17
IS  - 12
SP  - 370
EP  - 371
PB  - C.H. Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Hoffmann, Lisa
A1  - Wilbert, Jürgen
A1  - Lehofer, Mike
A1  - Schwab, Susanne
T1  - Are we good friends?
BT  - Friendship preferences and the quantity and quality of mutual friendships
JF  - European Journal of Special Needs Education
N2  - Empirical studies already examined various facets of the friendship construct. Building on this, the present study examines the questions of how the number of friendships and their quality differ between students with and without SEN and whether a homophily-effect can be identified. The sample consists of 455 fourth-graders from 28 inclusive classes in Austria. The results indicate that students with SEN have fewer friends than students without SEN. Furthermore, students without SEN preferred peers without SEN as a friend. This homophily-effect was shown for students with SEN, too. However, students with and without SEN rated the quality of their friendships similarly and no interactions between the SEN status of oneself or of the friend was found for the quality of the friendship. The results show that, in the context of inclusion, the issue of friendship needs to be increasingly addressed to improve the situation of students with SEN.
KW  - social participation
KW  - friendship
KW  - quality of friendship
KW  - homophily
KW  - sociometric nomination
Y1  - 2019
VL  - 36
IS  - 4
PB  - Taylor & Francis
CY  - London
ER  - 
TY  - JOUR
A1  - Nicenboim, Bruno
A1  - Vasishth, Shravan
A1  - Rösler, Frank
T1  - Are words pre-activated probabilistically during sentence comprehension?
BT  - evidence from new data and a Bayesian random-effects meta-analysis using publicly available data
JF  - Neuropsychologia : an international journal in behavioural and cognitive neuroscience
N2  - Several studies (e.g., Wicha et al., 2003b; DeLong et al., 2005) have shown that readers use information from the sentential context to predict nouns (or some of their features), and that predictability effects can be inferred from the EEG signal in determiners or adjectives appearing before the predicted noun. While these findings provide evidence for the pre-activation proposal, recent replication attempts together with inconsistencies in the results from the literature cast doubt on the robustness of this phenomenon. Our study presents the first attempt to use the effect of gender on predictability in German to study the pre-activation hypothesis, capitalizing on the fact that all German nouns have a gender and that their preceding determiners can show an unambiguous gender marking when the noun phrase has accusative case. Despite having a relatively large sample size (of 120 subjects), both our preregistered and exploratory analyses failed to yield conclusive evidence for or against an effect of pre-activation. The sign of the effect is, however, in the expected direction: the more unexpected the gender of the determiner, the larger the negativity. The recent, inconclusive replication attempts by Nieuwland et al. (2018) and others also show effects with signs in the expected direction. We conducted a Bayesian random-ef-fects meta-analysis using our data and the publicly available data from these recent replication attempts. Our meta-analysis shows a relatively clear but very small effect that is consistent with the pre-activation account and demonstrates a very important advantage of the Bayesian data analysis methodology: we can incrementally accumulate evidence to obtain increasingly precise estimates of the effect of interest.
KW  - ERP
KW  - pre-activation
KW  - predictions
KW  - grammatical gender
KW  - Bayesian meta-analysis
Y1  - 2020
U6  - https://doi.org/10.1016/j.neuropsychologia.2020.107427
SN  - 0028-3932
SN  - 1873-3514
VL  - 142
PB  - Elsevier Science
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Neitzel, Sönke
T1  - Armee der Einheit
BT  - Jörg Schönbohm und die Auflösung der Nationalen Volksarmee der DDR
JF  - Die politische Meinung
Y1  - 2020
SN  - 0032-3446
VL  - 65
IS  - 564
SP  - 115
EP  - 118
PB  - Konrad-Adenauer-Stiftung
CY  - Osnabrück
ER  - 
TY  - JOUR
A1  - Lettl, Tobias
T1  - Art. 102 AEUV, § 19 GWB und Rechtsbruch, insbesondere Verstöße gegen AGB-Recht und Datenschutzrecht
JF  - Wettbewerb in Recht und Praxis
Y1  - 2020
UR  - https://www.juris.de/perma?d=jzs-WRP-2020-11-1391-1400-1
SN  - 0172-049X
SN  - 1435-3059
VL  - 66
IS  - 11
SP  - 1391
EP  - 1400
PB  - dfv-Mediengruppe
CY  - Frankfurt am Main
ER  - 
TY  - JOUR
A1  - Thulin, Mirjam
T1  - Arthur Czellitzer (1871 – 1943) and the society for Jewish family research
JF  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Transformative Translations in Jewish History and Culture
N2  - In 1924, the Berlin ophthalmologist Arthur Czellitzer (1871–1943) and like-minded members of the local Jewish community founded the Society for Jewish Family Research. A year later, the Society launched the journal Jüdische Familienforschung (Jewish Family Research), edited by Czellitzer. The Society was an outstanding platform of professional academic and amateur researchers and promoted a type of Jewish genealogy and family history that was shaped by the historical-medical discourse of the time. The concepts and methods of both the biological sciences and Wissenschaft des Judentums shaped and defined the academic approach to family research and history in Czellitzer’s and the Society’s work. The Society soon became the leading international association for the academic Jewish genealogical research. Despite of its brutal end in 1938, Arthur Czellitzer’s and the Society’s works, the issues raised, and the methods they created shape Jewish family research and genealogy until today.
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485534
SN  - 978-3-86956-493-7
SN  - 1614-6492
SN  - 1862-7684
IS  - 26
SP  - 29
EP  - 42
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Herrero, Mario
A1  - Thornton, Philip K.
A1  - Mason-D'Croz, Daniel
A1  - Palmer, Jeda
A1  - Bodirsky, Benjamin Leon
A1  - Pradhan, Prajal
A1  - Barrett, Christopher B.
A1  - Benton, Tim G.
A1  - Hall, Andrew
A1  - Pikaar, Ilje
A1  - Bogard, Jessica R.
A1  - Bonnett, Graham D.
A1  - Bryan, Brett A.
A1  - Campbell, Bruce M.
A1  - Christensen, Svend
A1  - Clark, Michael
A1  - Fanzo, Jessica
A1  - Godde, Cecile M.
A1  - Jarvis, Andy
A1  - Loboguerrero, Ana Maria
A1  - Mathys, Alexander
A1  - McIntyre, C. Lynne
A1  - Naylor, Rosamond L.
A1  - Nelson, Rebecca
A1  - Obersteiner, Michael
A1  - Parodi, Alejandro
A1  - Popp, Alexander
A1  - Ricketts, Katie
A1  - Smith, Pete
A1  - Valin, Hugo
A1  - Vermeulen, Sonja J.
A1  - Vervoort, Joost
A1  - van Wijk, Mark
A1  - van Zanten, Hannah H. E.
A1  - West, Paul C.
A1  - Wood, Stephen A.
A1  - Rockström, Johan
T1  - Articulating the effect of food systems innovation on the Sustainable Development Goals
JF  - The lancet Planetary health
N2  - Food system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level.
Y1  - 2020
U6  - https://doi.org/10.1016/S2542-5196(20)30277-1
SN  - 2542-5196
VL  - 5
IS  - 1
SP  - E50
EP  - E62
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Wilkens, Martin
T1  - AS TIME GOES BY. Rythmizität Zyklizität - Kategorien zeitlicher Stukturierung
JF  - Zyklizität & Rhythmik: eine multidisziplinäre Vorlesungsreihe
Y1  - 2020
SN  - 978-3-86464-169-5
SP  - 71
EP  - 84
PB  - trafo
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Smith, Taylor
A1  - Bookhagen, Bodo
T1  - Assessing Multi-Temporal Snow-Volume Trends in High Mountain Asia From 1987 to 2016 Using High-Resolution Passive Microwave Data
JF  - Frontiers in Earth Science
N2  - High Mountain Asia (HMA) is dependent upon both the amount and timing of snow and glacier meltwater. Previous model studies and coarse resolution (0.25° × 0.25°, ∼25 km × 25 km) passive microwave assessments of trends in the volume and timing of snowfall, snowmelt, and glacier melt in HMA have identified key spatial and seasonal heterogeneities in the response of snow to changes in regional climate. Here we use recently developed, continuous, internally consistent, and high-resolution passive microwave data (3.125 km × 3.125 km, 1987–2016) from the special sensor microwave imager instrument family to refine and extend previous estimates of changes in the snow regime of HMA. We find an overall decline in snow volume across HMA; however, there exist spatially contiguous regions of increasing snow volume—particularly during the winter season in the Pamir, Karakoram, Hindu Kush, and Kunlun Shan. Detailed analysis of changes in snow-volume trends through time reveal a large step change from negative trends during the period 1987–1997, to much more positive trends across large regions of HMA during the periods 1997–2007 and 2007–2016. We also find that changes in high percentile monthly snow-water volume exhibit steeper trends than changes in low percentile snow-water volume, which suggests a reduction in the frequency of high snow-water volumes in much of HMA. Regions with positive snow-water storage trends generally correspond to regions of positive glacier mass balances.
KW  - snow
KW  - glacier
KW  - climate change
KW  - passive microwave
KW  - special sensor microwave imager
KW  - special sensor microwave imager/sounder
Y1  - 2020
U6  - https://doi.org/10.3389/feart.2020.559175
SN  - 2296-6463
VL  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - D'Ascenzo, Stefania
A1  - Lugli, Luisa
A1  - Nicoletti, Roberto
A1  - Fischer, Martin H.
T1  - Assessing orienting of attention to understand the time course of mental calculation
JF  - Cognitive processing : international quarterly of cognitive science
N2  - Number processing induces spatial attention shifts to the left or right side for small or large numbers, respectively. This spatial-numerical association (SNA) extends to mental calculation, such that subtractions and additions induce left or right biases, respectively. However, the time course of activating SNAs during mental calculation is unclear. Here, we addressed this issue by measuring visual position discrimination during auditory calculation. Thirty-four healthy adults listened in each trial to five successive elements of arithmetic facts (first operand, operator, second operand, equal and result) and verbally classified their correctness. After each element (except for the result), a fixation dot moved equally often to either the left or right side and participants pressed left or right buttons to discriminate its movement direction (four times per trial). First and second operand magnitude (small/large), operation (addition/subtraction), result correctness (right/wrong) and movement direction (left/right) were balanced across 128 trials. Manual reaction times of dot movement discriminations were considered in relation to previous arithmetic elements. We found no evidence of early attentional shifts after first operand and operator presentation. Discrimination performance was modulated consistent with SNAs after the second operand, suggesting that attentional shifts occur once there is access to all elements necessary to complete an arithmetic operation. Such late-occurring attention shifts may reflect a combination of multiple element-specific biases and confirm their functional role in mental calculation.
KW  - Attention
KW  - Mental arithmetic
KW  - Numerical cognition
KW  - Spatial-numerical
KW  - associations
Y1  - 2020
U6  - https://doi.org/10.1007/s10339-020-00970-y
SN  - 1612-4782
SN  - 1612-4790
VL  - 21
IS  - 4
SP  - 493
EP  - 500
PB  - Springer
CY  - Heidelberg ; Berlin
ER  - 
TY  - JOUR
A1  - Jing, Miao
A1  - Kumar, Rohini
A1  - Heße, Falk
A1  - Thober, Stephan
A1  - Rakovec, Oldrich
A1  - Samaniego, Luis
A1  - Attinger, Sabine
T1  - Assessing the response of groundwater quantity and travel time distribution to 1.5, 2, and 3 °C global warming in a mesoscale central German basin
JF  - Hydrology and Earth System Sciences
N2  - Groundwater is the biggest single source of high-quality freshwater worldwide, which is also continuously threatened by the changing climate. In this paper, we investigate the response of the regional groundwater system to climate change under three global warming levels (1.5, 2, and 3 ∘C) in a central German basin (Nägelstedt). This investigation is conducted by deploying an integrated modeling workflow that consists of a mesoscale hydrologic model (mHM) and a fully distributed groundwater model, OpenGeoSys (OGS). mHM is forced with climate simulations of five general circulation models under three representative concentration pathways. The diffuse recharges estimated by mHM are used as boundary forcings to the OGS groundwater model to compute changes in groundwater levels and travel time distributions. Simulation results indicate that groundwater recharges and levels are expected to increase slightly under future climate scenarios. Meanwhile, the mean travel time is expected to decrease compared to the historical average. However, the ensemble simulations do not all agree on the sign of relative change. Changes in mean travel time exhibit a larger variability than those in groundwater levels. The ensemble simulations do not show a systematic relationship between the projected change (in both groundwater levels and travel times) and the warming level, but they indicate an increased variability in projected changes with adjusting the enhanced warming level from 1.5 to 3 ∘C. Correspondingly, it is highly recommended to restrain the trend of global warming.
KW  - climate change impacts
KW  - hydrological models
KW  - coupled surface
KW  - water fluxes
KW  - catchment
KW  - recharge
KW  - dynamics
KW  - aquifer
KW  - flow
KW  - parameterization
Y1  - 2020
U6  - https://doi.org/10.5194/hess-24-1511-2020
SN  - 1607-7938
SN  - 1027-5606
VL  - 24
IS  - 3
SP  - 1511
EP  - 1526
PB  - Copernicus Publ.
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Cavael, Ulrike
A1  - Diehl, Katharina
A1  - Lentzsch, Peter
T1  - Assessment of growth suppression in apple production with replant soils
JF  - Ecological indicators : integrating monitoring, assessment and management
N2  - Apple replant disease (ARD) is a specific apple-related form of soil fertility loss due to unidentified causes and is also known as soil fatigue. The effect typically appears in monoculture production sites and leads to production decreases of up to 50%, even though the cultivation practice remains the same. However, an indication of replant disease is challenged by the lack of specification of the particular microbial group responsible for ARD. The objective of this study was to establish an algorithm for estimating growth suppression in orchards irrespective of the unknowns in the complex causal relationship by assessing plant-soil interaction in the orchard several years after planting. Based on a comparison between no-replant and replant soils, the Alternaria group (Ag) was identified as a soil-fungal population responding to replant with abundance. The trunk cross-sectional area (CSA) was found to be a practical and robust parameter representing below-ground and above-ground tree performance. Suppression of tree vigour was therefore calculated by dividing the two inversely related parameters, Q = ln(Ag)/CSA, as a function of soil-fungal proportions and plant responses at the single-tree level. On this basis, five clusters of tree vigour suppression (Q) were defined: (1) no tree vigour suppression/vital (0%), (2) escalating (- 38%), (3) strong (- 53%), (4) very strong (- 62%), and (5) critical (- 74%). By calculating Q at the level of the single tree, trees were clustered according to tree vigour suppression. The weighted frequency of clusters in the field allowed replant impact to be quantified at field level. Applied to a case study on sandy brown, dry diluvial soils in Brandenburg, Germany, the calculated tree vigour suppression was 46% compared to the potential tree vigour on no-replant soil in the same field. It is highly likely that the calculated growth suppression corresponds to ARD-impact This result is relevant for identifying functional changes in soil and for monitoring the economic effects of soil fatigue in apple orchards, particularly where long-period crop rotation or plot exchange are improbable.
KW  - orchard management
KW  - trunk cross-sectional area
KW  - alternaria group
KW  - apple
KW  - production
KW  - soil fatigue
KW  - apple replant disease
Y1  - 2020
U6  - https://doi.org/10.1016/j.ecolind.2019.105846
SN  - 1470-160X
SN  - 1872-7034
VL  - 109
PB  - Elsevier Science
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Cavael, Ulrike
A1  - Diehl, Katharina
A1  - Lentzsch, Peter
T1  - Assessment of growth suppression in apple production with replant soils
JF  - Ecological indicators : integrating monitoring, assessment and management
N2  - Apple replant disease (ARD) is a specific apple-related form of soil fertility loss due to unidentified causes and is also known as soil fatigue. The effect typically appears in monoculture production sites and leads to production decreases of up to 50%, even though the cultivation practice remains the same. However, an indication of replant disease is challenged by the lack of specification of the particular microbial group responsible for ARD. The objective of this study was to establish an algorithm for estimating growth suppression in orchards irrespective of the unknowns in the complex causal relationship by assessing plant-soil interaction in the orchard several years after planting. Based on a comparison between no-replant and replant soils, the Alternaria group (Ag) was identified as a soil-fungal population responding to replant with abundance. The trunk cross-sectional area (CSA) was found to be a practical and robust parameter representing below-ground and above-ground tree performance. Suppression of tree vigour was therefore calculated by dividing the two inversely related parameters, Q = ln(Ag)/CSA, as a function of soil-fungal proportions and plant responses at the single-tree level. On this basis, five clusters of tree vigour suppression (Q) were defined: (1) no tree vigour suppression/vital (0%), (2) escalating (- 38%), (3) strong (- 53%), (4) very strong (- 62%), and (5) critical (- 74%). By calculating Q at the level of the single tree, trees were clustered according to tree vigour suppression. The weighted frequency of clusters in the field allowed replant impact to be quantified at field level. Applied to a case study on sandy brown, dry diluvial soils in Brandenburg, Germany, the calculated tree vigour suppression was 46% compared to the potential tree vigour on no-replant soil in the same field. It is highly likely that the calculated growth suppression corresponds to ARD-impact This result is relevant for identifying functional changes in soil and for monitoring the economic effects of soil fatigue in apple orchards, particularly where long-period crop rotation or plot exchange are improbable.
KW  - orchard management
KW  - trunk cross-sectional area
KW  - alternaria group
KW  - apple
KW  - production
KW  - soil fatigue
KW  - apple replant disease
Y1  - 2019
U6  - https://doi.org/10.1016/j.ecolind.2019.105846
SN  - 1470-160X
SN  - 1872-7034
VL  - 109
PB  - Elsevier Science
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Saberi Hosnijeh, Fatemeh
A1  - Casabonne, Delphine
A1  - Nieters, Alexandra
A1  - Solans, Marta
A1  - Naudin, Sabine
A1  - Ferrari, Pietro
A1  - Mckay, James D.
A1  - Benavente, Yolanda
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Severi, Gianluca
A1  - Boutron Ruault, Marie-Christine
A1  - Besson, Caroline
A1  - Agnoli, Claudia
A1  - Masala, Giovanna
A1  - Sacerdote, Carlotta
A1  - Tumino, Rosario
A1  - Huerta, Jose Maria
A1  - Amiano, Pilar
A1  - Rodriguez-Barranco, Miguel
A1  - Bonet, Catalina
A1  - Barricarte, Aurelio
A1  - Christakoudi, Sofia
A1  - Knuppel, Anika
A1  - Bueno-de-Mesquita, Bas
A1  - Schulze, Matthias Bernd
A1  - Kaaks, Rudolf
A1  - Canzian, Federico
A1  - Spath, Florentin
A1  - Jerkeman, Mats
A1  - Rylander, Charlotta
A1  - Tjonneland, Anne
A1  - Olsen, Anja
A1  - Borch, Kristin Benjaminsen
A1  - Vermeulen, Roel
T1  - Association between anthropometry and lifestyle factors and risk of B-cell lymphoma
BT  - an exposome-wide analysis
JF  - International journal of cancer
N2  - To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
KW  - exposome
KW  - exposome‐ wide association study
KW  - lifestyle
KW  - lymphoma
KW  - prospective study
Y1  - 2020
U6  - https://doi.org/10.1002/ijc.33369
SN  - 0020-7136
SN  - 1097-0215
VL  - 148
IS  - 9
SP  - 2115
EP  - 2128
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Arazi, Hamid
A1  - Asadi, Abbas
A1  - Khalkhali, Farhood
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players
BT  - A Preliminary Study
N2  - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r²) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
KW  - training load
KW  - rate of perceived exertion
KW  - rolling averages
KW  - weighted moving averages
KW  - football
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00608
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Arazi, Hamid
A1  - Asadi, Abbas
A1  - Khalkhali, Farhood
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players
BT  - A Preliminary Study
JF  - Frontiers in Physiology
N2  - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r 2) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
KW  - training load
KW  - rate of perceived exertion
KW  - rolling averages
KW  - weighted moving averages
KW  - football
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00995
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wachs, Sebastian
A1  - Görzig, Anke
A1  - Wright, Michelle F.
A1  - Schubarth, Wilfried
A1  - Bilz, Ludwig
T1  - Associations among Adolescents’ Relationships with Parents, Peers, and Teachers, Self-Efficacy, and Willingness to Intervene in Bullying
BT  - A Social Cognitive Approach
JF  - International Journal of Environmental Research and Public Health
N2  - We applied the Social Cognitive Theory to investigate whether parent–child relationships, bullying victimization, and teacher–student relationships are directly as well as indirectly via self-efficacy in social conflicts associated with adolescents’ willingness to intervene in a bullying incident. There were 2071 (51.3% male) adolescents between the ages of 12 and 17 from 24 schools in Germany who participated in this study. A mediation test using structural equation modeling revealed that parent–child relationships, bullying victimization, and teacher–student relationships were directly related to adolescents’ self-efficacy in social conflicts. Further, teacher–student relationships and bullying victimization were directly associated with adolescents’ willingness to intervene in bullying. Finally, relationships with parents, peers and teachers were indirectly related to higher levels of students’ willingness to intervene in bullying situations due to self-efficacy in social conflicts. Thus, our analysis confirms the general assumptions of Social Cognitive Theory and the usefulness of applying its approach to social conflicts such as bullying situations.
KW  - bullying
KW  - intervention
KW  - willingness to intervene
KW  - bullying victimization
KW  - school
KW  - parent–child relationship
KW  - teacher–student relationship
KW  - self-efficacy
Y1  - 2020
U6  - https://doi.org/10.3390/ijerph17020420
SN  - 1660-4601
SN  - 1661-7827
VL  - 17
IS  - 2
PB  - MDPI AG
CY  - Basel
ER  - 
TY  - JOUR
A1  - Granacher, Urs
A1  - Nobari, Hadi
A1  - Ruivo Alves, Ana
A1  - Clemente, Filipe Manuel
A1  - Pérez-Gómez, Jorge
A1  - Clark, Cain Craig Truman
A1  - Zouhal, Hassane
T1  - Associations Between Variations in Accumulated Workload and Physiological Variables in Young Male Soccer Players Over the Course of a Season
JF  - Frontiers in physiology
N2  - This study sought to analyze the relationship between in-season training workload with changes in aerobic power (VO2max), maximum and resting heart rate (HRmax and HRrest), linear sprint medium (LSM), and short test (LSS), in soccer players younger than 16 years (under-16 soccer players). We additionally aimed to explain changes in fitness levels during the in-season through regression models, considering accumulated load, baseline levels, and peak height velocity (PHV) as predictors. Twenty-three male sub-elite soccer players aged 15.5 ± 0.2 years (PHV: 13.6 ± 0.4 years; body height: 172.7 ± 4.2 cm; body mass: 61.3 ± 5.6 kg; body fat: 13.7% ± 3.9%; VO2max: 48.4 ± 2.6 mL⋅kg–1⋅min–1), were tested three times across the season (i.e., early-season (EaS), mid-season (MiS), and end-season (EnS) for VO2max, HRmax, LSM, and LSS. Aerobic and speed variables gradually improved over the season and had a strong association with PHV. Moreover, the HRmax demonstrated improvements from EaS to EnS; however, this was more evident in the intermediate period (from EaS to MiS) and had a strong association with VO2max. Regression analysis showed significant predictions for VO2max [F(2, 20) = 8.18, p ≤ 0.001] with an R2 of 0.45. In conclusion, the meaningful variation of youth players’ fitness levels can be observed across the season, and such changes can be partially explained by the load imposed.
KW  - internal load
KW  - heart rate
KW  - linear sprint
KW  - aerobic power
KW  - football
Y1  - 2021
U6  - https://doi.org/10.3389/fphys.2021.638180
SN  - 1664-042X
VL  - 12
SP  - 1
EP  - 12
PB  - Frontiers Research Foundation
CY  - Lausanne, Schweiz
ER  - 
TY  - JOUR
A1  - Urbach, Dietmar
A1  - Awiszus, Friedemann
A1  - Leiß, Sven
A1  - Venton, Tamsin
A1  - De Specht, Alexander Vincent
A1  - Apfelbacher, Christian
T1  - Associations of medications with lower odds of typical COVID-19 symptoms
BT  - cross-sectional symptom surveillance study
JF  - JMIR public health and surveillance
N2  - Background: As the COVID-19 pandemic continues to spread across the globe, the search for an effective medication to treat the symptoms of COVID-19 continues as well. It would be desirable to identify a medication that is already in use for another condition and whose side effect profile and safety data are already known and approved.
Objective: The objective of this study was to evaluate the effect of different medications on typical COVID-19 symptoms by using data from an online surveillance survey.
Methods: Between early April and late-July 2020, a total of 3654 individuals in Lower Saxony, Germany, participated in an online symptom-tracking survey conducted through the app covid-nein-danke.de. The questionnaire comprised items on typical COVID-19 symptoms, age range, gender, employment in patient-facing healthcare, housing status, postal code, previous illnesses, permanent medication, vaccination status, results of reverse transcription polymerase chain reaction (RT-PCR) and antibody tests for COVID-19 diagnosis, and consequent COVID-19 treatment if applicable. Odds ratio estimates with corresponding 95% CIs were computed for each medication and symptom by using logistic regression models.
Results: Data analysis suggested a statistically significant inverse relationship between typical COVID-19 symptoms self-reported by the participants and self-reported statin therapy and, to a lesser extent, antihypertensive therapy. When COVID-19 diagnosis was based on restrictive symptom criteria (ie, presence of 4 out of 7 symptoms) or a positive RT-PCR test, a statistically significant association was found solely for statins (odds ratio 0.28, 95% CI 0.1-0.78).
Conclusions: Individuals taking statin medication are more likely to have asymptomatic COVID-19, in which case they may be at an increased risk of transmitting the disease unknowingly. We suggest that the results of this study be incorporated into symptoms-based surveillance and decision-making protocols in regard to COVID-19 management. Whether statin therapy has a beneficial effect in combating COVID-19 cannot be deduced based on our findings and should be investigated by further study.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - statins
KW  - antihypertensives
KW  - surveillance
KW  - hydroxymethyl-glutaryl-coenzyme A reductase inhibitors;online survey
Y1  - 2020
U6  - https://doi.org/10.2196/22521
SN  - 2369-2960
VL  - 6
IS  - 4
PB  - JMIR Publications
CY  - Toronto
ER  - 
TY  - JOUR
A1  - Helm, Norman
A1  - Prieske, Olaf
A1  - Mühlbauer, Thomas
A1  - Krüger, Tom
A1  - Retzlaff, Matthias
A1  - Granacher, Urs
T1  - Associations between trunk muscle strength and judo-specific pulling performances in judo athletes
T1  - Assoziationen zwischen der Rumpfkraft und judospezifischen Anriss-Leistungen von Judoka
JF  - Sportverletzung, Sportschaden : Grundlagen, Prävention, Rehabilitation
N2  - Background:
Good trunk stability is an important prerequisite for the mobility of the upper and lower limbs during sport-specific movements. Therefore, trunk muscle strength may represent an important performance determinant for judo-specific movements. This study aimed at evaluating statistical correlations between trunk muscle strength and kinetic parameters during judo-specific pulling movements in judo players. 

Method:
Twenty-one male sub-elite judo players aged 22 +/- 4 years with a mean training volume of 15 +/- 4 hours per week participated in this study. Peak isokinetic torque (PIT) of the trunk flexors (PITFlex), extensors (PITEx) and rotators (PITRot) was tested using an isokinetic dynamometer (IsoMed 2000). In addition, two kinetic parameters (mechanical work [W], maximal force [F-max]) were analysed using the judo-specific measurement and information system JERGo (c). For this purpose, athletes were asked to do their judo-specific pulling movements while standing and with a dynamic change of position (i.e. Morote-seoi-nage). 

Results:
Regarding pulling movements while standing, significant correlations (0.62 <= r(P) <= 0.72) were found between isokinetic tests (PITFlex, PITEx, PITRot) and mechanical work during judo-specific movement. Further, significant correlations (0.59 <= r(P) <= 0.65) were detected between isokinetic tests (PITEx, PITRot) and judo-specific pulling movements (Fmax). Regarding pulling movements with a change of position, significant correlations (0.47 <= r(P) <= 0.88) were observed between isokinetics (PITFlex, PITEx, PITRot) and the kinetic pulling parameters (W, Fmax), irrespective of the examined arm. No significant differences in magnitude of correlation coefficients were found between PIT of the trunk flexors, extensors, and rotators and judo-specific movements. Further, the regression analysis indicated that PIT of the trunk extensors is the single best predictor for mechanical work during pulling movements while standing (46.9 %). Trunk rotator PIT is the single best predictor for mechanical work during pulling movements with a change of position (69.4 %).

Conclusions:
Findings from this study indicate that trunk muscle strength, particularly trunk rotator PIT is associated with kinetic pulling variables during pulling movements with a change of position. This implies that the development of trunk rotator strength could have an impact on pulling movements with a change of position (i.e. Morote-seoi-nage) in judo athletes.
N2  - Hintergrund:
Eine gut ausgeprägte Rumpfstabilität ist eine wichtige Voraussetzung für die Mobilität der oberen und unteren Extremitäten während des sportlichen Bewegungsvollzugs. Vor diesem Hintergrund könnte die Rumpfkraft ein leistungsdeterminierender Faktor bei der Ausführung judospezifischer Bewegungen darstellen. Das Ziel der vorliegenden Studie war es, statistische Zusammenhänge zwischen der Rumpfkraft und kinetischen Parametern bei Anriss-Bewegungen von Judoka zu untersuchen.

Methode:
An der Untersuchung nahmen 21 leistungsorientierte Judoka mit einem mittleren Alter von 22 ± 4 Jahre und einem Trainingsumfang von 15 ± 4 Stunden pro Woche teil. Das maximale isokinetische Drehmoment (PIT) der Rumpfflexoren (PITFlex), -extensoren (PITEx) und -rotatoren (PITRot) wurde unter Verwendung eines isokinetischen Dynamometers (IsoMed 2000) erfasst. Zusätzlich wurden kinetische Parameter (mechanische Arbeit [W], dynamisch-realisierte Maximalkraft [Fmax]) bei Anriss-Bewegung im Stand und bei Anriss- mit Eindrehbewegung (d. h. Morote-seoi-nage) mithilfe eines judospezifischen Mess- und Informationssystems (JERGo©) erhoben.

Ergebnisse:
Die statistische Analyse zeigte signifikante Korrelationen (0,62 ≤ r P ≤ 0,72) zwischen den maximalen isokinetischen Drehmomenten (PITFlex, PITEx, PITRot) und der Anriss-Bewegung im Stand (W). Zudem konnten signifikante Zusammenhänge (0,59 ≤ r P ≤ 0,65) zwischen den isokinetischen Tests (PITEx, PITRot) und Fmax auf der Hubarmseite bei der Anriss-Bewegung im Stand gefunden werden. Für die Anriss- mit Eindrehbewegung ergaben sich signifikante Korrelationen (0,47 ≤ r P ≤ 0,88) zwischen den isokinetischen Tests (PITFlex, PITEx, PITRot) und Leistungskennwerten der judospezifischen Bewegung (W und Fmax), unabhängig von der untersuchten Armseite. Es wurden vergleichbare Korrelationskoeffizienten zwischen PIT der Rumpfflexoren, -extensoren und -rotatoren und judospezifischen Leistungskennwerten festgestellt. Weiterhin identifizierte die Regressionsanalyse den Kennwert PIT bei Rumpfextension als besten Prädiktor für die mechanische Arbeit bei Anriss-Bewegung im Stand (46,9 %). Bei der Anriss- mit Eindrehbewegung konnte PIT der Rumpfrotatoren auf die Hubarmseite als bester Prädiktor für die mechanische Arbeit (69,4 %) ermittelt werden.

Schlussfolgerung: 
Die Ergebnisse zeigen, dass die Rumpfkraft, insbesondere bei der Rumpfrotationsbewegung, mit Variablen der judospezifischen Leistungskennwerte bei der Anriss- mit Eindrehbewegung assoziiert ist. Dies impliziert, dass vor allem durch rumpfrotationskräftigende Übungen Einfluss auf die Anriss- mit Eindrehbewegung (d. h. Morote-seoi-nage) genommen werden könnte.
KW  - combat sport
KW  - athletic performance
KW  - Morote-seoi-nage
KW  - Kampfsport
KW  - sportliche Leistung
Y1  - 2020
U6  - https://doi.org/10.1055/a-0677-9608
SN  - 0932-0555
SN  - 1439-1236
VL  - 34
IS  - 1
SP  - 18
EP  - 27
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Ludewig, Matthias
A1  - Rosenberger, Elke
T1  - Asymptotic eigenfunctions for Schrödinger operators on a vector bundle
JF  - Reviews in mathematical physics
N2  - In the limit (h) over bar -> 0, we analyze a class of Schrödinger operators H-(h) over bar = (h) over bar L-2 + (h) over barW + V .id(epsilon) acting on sections of a vector bundle epsilon over a Riemannian manifold M where L is a Laplace type operator, W is an endomorphism field and the potential energy V has a non-degenerate minimum at some point p is an element of M. We construct quasimodes of WKB-type near p for eigenfunctions associated with the low-lying eigenvalues of H-(h) over bar. These are obtained from eigenfunctions of the associated harmonic oscillator H-p,H-(h) over bar at p, acting on smooth functions on the tangent space.
KW  - Semi-classical analysis
KW  - WKB approximation
KW  - Schrödinger operators
KW  - semi-classical limit
Y1  - 2020
U6  - https://doi.org/10.1142/S0129055X20500208
SN  - 0129-055X
SN  - 1793-6659
VL  - 32
IS  - 7
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Ly, Ibrahim
A1  - Tarkhanov, Nikolaj Nikolaevič
T1  - Asymptotic expansions at nonsymmetric cuspidal points
JF  - Mathematical notes
N2  - We study the asymptotics of solutions to the Dirichlet problem in a domain X subset of R3 whose boundary contains a singular point O. In a small neighborhood of this point, the domain has the form {z > root x(2) + y(4)}, i.e., the origin is a nonsymmetric conical point at the boundary. So far, the behavior of solutions to elliptic boundary-value problems has not been studied sufficiently in the case of nonsymmetric singular points. This problem was posed by V.A. Kondrat'ev in 2000. We establish a complete asymptotic expansion of solutions near the singular point.
KW  - Dirichlet problem
KW  - singular points
KW  - asymptotic expansions
Y1  - 2020
U6  - https://doi.org/10.1134/S0001434620070238
SN  - 0001-4346
SN  - 1573-8876
VL  - 108
IS  - 1-2
SP  - 219
EP  - 228
PB  - Springer Science
CY  - New York
ER  - 
TY  - JOUR
A1  - Castino, Fabiana
A1  - Bookhagen, Bodo
A1  - De la Torre, Alejandro
T1  - Atmospheric dynamics of extreme discharge events from 1979 to 2016 in the southern Central Andes
JF  - Climate dynamics : observational, theoretical and computational research on the climate system
N2  - During the South-American Monsoon season, deep convective systems occur at the eastern flank of the Central Andes leading to heavy rainfall and flooding. We investigate the large- and meso-scale atmospheric dynamics associated with extreme discharge events (> 99.9th percentile) observed in two major river catchments meridionally stretching from humid to semi-arid conditions in the southern Central Andes. Based on daily gauge time series and ERA-Interim reanalysis, we made the following three key observations: (1) for the period 1940-2016 daily discharge exhibits more pronounced variability in the southern, semi-arid than in the northern, humid catchments. This is due to a smaller ratio of discharge magnitudes between intermediate (0.2 year return period) and rare events (20 year return period) in the semi-arid compared to the humid areas; (2) The climatological composites of the 40 largest discharge events showed characteristic atmospheric features of cold surges based on 5-day time-lagged sequences of geopotential height at different levels in the troposphere; (3) A subjective classification revealed that 80% of the 40 largest discharge events are mainly associated with the north-northeastward migration of frontal systems and 2/3 of these are cold fronts, i.e. cold surges. This work highlights the importance of cold surges and their related atmospheric processes for the generation of heavy rainfall events and floods in the southern Central Andes.
KW  - South American monsoon system
KW  - cold surges
KW  - orographic barrier
KW  - mesoscale convective systems
KW  - extreme discharge
KW  - daily-discharge time
KW  - series ERA-interim
Y1  - 2019
U6  - https://doi.org/10.1007/s00382-020-05458-1
SN  - 0930-7575
SN  - 1432-0894
VL  - 55
IS  - 11-12
SP  - 3485
EP  - 3505
PB  - Springer
CY  - Berlin ; Heidelberg [u.a.]
ER  - 
TY  - JOUR
A1  - Wright, Stephanie L.
A1  - Ulke, Jannis
A1  - Font, Anna
A1  - Chan, Ka Lung Andrew
A1  - Kelly, Frank J.
T1  - Atmospheric microplastic deposition in an urban environment and an evaluation of transport
JF  - Environment international
N2  - Microplastics are a global environmental issue contaminating aquatic and terrestrial environments. They have been reported in atmospheric deposition, and indoor and outdoor air, raising concern for public health due to the potential for exposure. Moreover, the atmosphere presents a new vehicle for microplastics to enter the wider environment, yet our knowledge of the quantities, characteristics and pathways of airborne microplastics is sparse. Here we show microplastics in atmospheric deposition in a major population centre, central London. Microplastics were found in all samples, with deposition rates ranging from 575 to 1008 microplastics/m(2)/d. They were found in various shapes, of which fibrous microplastics accounted for the great majority (92%). Across all samples, 15 different petrochemical-based polymers were identified. Bivariate polar plots indicated dependency on wind, with different source areas for fibrous and non-fibrous airborne microplastics. This is the first evidence of airborne microplastics in London and confirms the need to include airborne pathways when consolidating microplastic impacts on the wider environment and human health.
KW  - microplastics
KW  - atmospheric deposition
KW  - air pollution
KW  - urban
Y1  - 2020
U6  - https://doi.org/10.1016/j.envint.2019.105411
SN  - 0160-4120
SN  - 1873-6750
VL  - 136
PB  - Elsevier, Pergamon Press
CY  - New York, NY [u.a.]
ER  - 
TY  - JOUR
A1  - Mühlenbeck, Cordelia Anna
A1  - Pritsch, Carla
A1  - Wartenburger, Isabell
A1  - Telkemeyer, Silke
A1  - Liebal, Katja
T1  - Attentional bias to facial expressions of different emotions
BT  - a cross-cultural comparison of ≠Akhoe Hai||om and German children and adolescents
JF  - Frontiers in psychology
N2  - The attentional bias to negative information enables humans to quickly identify and to respond appropriately to potentially threatening situations. Because of its adaptive function, the enhanced sensitivity to negative information is expected to represent a universal trait, shared by all humans regardless of their cultural background. However, existing research focuses almost exclusively on humans from Western industrialized societies, who are not representative for the human species. Therefore, we compare humans from two distinct cultural contexts: adolescents and children from Germany, a Western industrialized society, and from the not equal Akhoe Hai parallel to om, semi-nomadic hunter-gatherers in Namibia. We predicted that both groups show an attentional bias toward negative facial expressions as compared to neutral or positive faces. We used eye-tracking to measure their fixation duration on facial expressions depicting different emotions, including negative (fear, anger), positive (happy), and neutral faces. Both Germans and the not equal Akhoe Hai parallel to om gazed longer at fearful faces, but shorter on angry faces, challenging the notion of a general bias toward negative emotions. For happy faces, fixation durations varied between the two groups, suggesting more flexibility in the response to positive emotions. Our findings emphasize the need for placing research on emotion perception into an evolutionary, cross-cultural comparative framework that considers the adaptive significance of specific emotions, rather than differentiating between positive and negative information, and enables systematic comparisons across participants from diverse cultural backgrounds.
KW  - attentional bias
KW  - fear bias
KW  - emotions
KW  - facial expressions
KW  - cross-cultural comparison
KW  - not equal Akhoe Hai parallel to om
KW  - Germans
KW  - adolescents
Y1  - 2020
U6  - https://doi.org/10.3389/fpsyg.2020.00795
SN  - 1664-1078
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bobzien, Licia
A1  - Kalleitner, Fabian
T1  - Attitudes towards European financial solidarity during the Covid-19 pandemic
BT  - evidence from a net-contributor country
JF  - European societies
N2  - Whilst the Covid-19 pandemic affects all European countries, the ways in which these countries are prepared for the health and subsequent economic crisis varies considerably. Financial solidarity within the European Union (EU) could mitigate some of these inequalities but depends upon the support of the citizens of individual member states for such policies. This paper studies attitudes of the Austrian population - a net-contributor to the European budget - towards financial solidarity using two waves of the Austrian Corona Panel Project collected in May and June 2020. We find that individuals (i) who are less likely to consider the Covid-19 pandemic as a national economic threat, (ii) who believe that Austria benefits from supporting other countries, and (iii) who prefer the crisis to be organized more centrally at EU-level show higher support for European financial solidarity. Using fixed effects models, we further show that perceiving economic threats and preferring central crisis management also explain attitude dynamics within individuals over time. We conclude that cost-benefit perceptions are important determinants for individual support of European financial solidarity during the Covid-19 pandemic.
KW  - Covid-19
KW  - financial solidarity
KW  - European Union
KW  - Austria
Y1  - 2020
U6  - https://doi.org/10.1080/14616696.2020.1836669
SN  - 1461-6696
SN  - 1469-8307
VL  - 23
IS  - Sup. 1
SP  - S791
EP  - S804
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Ozcelikay, Goksu
A1  - Kurbanoglu, Sevinc
A1  - Yarman, Aysu
A1  - Scheller, Frieder W.
A1  - Ozkan, Sibel A.
T1  - Au-Pt nanoparticles based molecularly imprinted nanosensor for electrochemical detection of the lipopeptide antibiotic drug Daptomycin
JF  - Sensors and actuators : B, Chemical
N2  - In this work, a novel electrochemical molecularly imprinted polymer (MIP) sensor for the detection of the lipopeptide antibiotic Daptomycin (DAP) is presented which integrates gold decorated platinum nanoparticles (Au-Pt NPs) into the nanocomposite film. The sensor was prepared by electropolymerization of o-phenylenediamine (o-PD) in the presence of DAP using cyclic voltammetry. Cyclic voltammetry and differential pulse voltammetry were applied to follow the changes in the MIP-layer related to rebinding and removal of the target DAP by using the redox marker [Fe(CN)(6)](3-/4-). Under optimized operational conditions, the MIP/Au-Pt NPs/ GCE nanosensor exhibits a linear response in the range of 1-20 pM towards DAP. The limit of detection and limit of quantification were determined to be 0.161pM +/- 0.012 and 0.489pM +/- 0.012, respectively. The sensitivity towards the antibiotics Vancomycin and Erythromycin and the amino acids glycine and tryptophan was below 7 percent as compared with DAP. Moreover, the nanosensor was also successfully used for the detection of DAP in deproteinated human serum samples.
KW  - molecularly imprinted polymer
KW  - Daptomycin
KW  - platinum nanoparticles
KW  - gold
KW  - nanoparticles
KW  - modified electrodes
Y1  - 2020
U6  - https://doi.org/10.1016/j.snb.2020.128285
SN  - 0925-4005
VL  - 320
PB  - Elsevier Science
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Thomas, Linda
T1  - Auf dem Weg zu 100 Prozent Open Access
T1  - Bound for one-hundred percent Open Access
BT  - Fünf Jahre DFG-geförderter Publikationsfonds und die Entwicklung notwendiger Infrastruktur an der Universität Potsdam
BT  - DFG-sponsored publication funding and the development of infrastructure needed at Potsdam University – five years on
JF  - Bibliotheksdienst
N2  - Die Universität Potsdam verwaltet seit 2015 einen DFG-geförderten Publikationsfonds. In den Publikationsjahren 2015 und 2017 wurden Outputanalysen durchgeführt. Open Access ist seit 2018 ein zentraler Bestandteil des Mittelverteilungsmodells. Der Artikel thematisiert die zentralen Erkenntnisse der letzten fünf Jahre und illustriert die entstandene Infrastruktur. Außerdem werden aktuelle Herausforderungen und mögliche Lösungsansätze der Transformation auf dem Weg hin zu 100 Prozent Open Access thematisiert.
N2  - Since 2015, the University of Potsdam has been managing a publication fund sponsored by the German Research Foundation. Output analyses were carried out for the publication years 2015 and 2017. Open Access has been a key component of the fund distribution model since 2018. The article discusses key findings of the past five years and explains the infrastructure created for the task. It also discusses current challenges and possible approaches to paving the way for 100 percent Open Access publications.
KW  - Open Access
KW  - DFG
KW  - Publikationsfonds
KW  - Outputanalyse
KW  - Transformation
KW  - Etatverteilungsmodell
KW  - Zweitveröffentlichung
Y1  - 2020
U6  - https://doi.org/10.1515/bd-2020-0069
SN  - 0006-1972
SN  - 2194-9646
VL  - 54
IS  - 7-8
SP  - 545
EP  - 558
PB  - de Gruyter
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pröve, Ralf
ED  - Mihalyi, Sandor
ED  - Petsche, Hans-Joachim
T1  - Aufgaben und Ziele der Geschichtswissenschaft in Forschung und Lehre
BT  - Perspektiven, Hürden und Potenziale
JF  - Philosophie und Weltbild: Philosophie und Wissenschaft im Diskurs : ein interdisziplinäres Projekt
Y1  - 2020
SN  - 978-3-86464-208-1
VL  - 6
SP  - 69
EP  - 103
PB  - trafo Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Pröve, Ralf
T1  - Aufgaben und Ziele der Geschichtswissenschaft in Forschung und Lehre. Perspektiven, Hürden und Potenziale
JF  - Philosophie & Weltbild : Philosophie und Wissenschaft im Diskurs - ein interdisziplinäres Projekt
Y1  - 2020
SN  - 978-3-86464-208-1
SP  - 69
EP  - 103
PB  - trafo
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Lass, Sander
T1  - Augmented Reality in der Fabrik
JF  - Fabriksoftware : die digitale Fabrik realisieren
N2  - Im Zentrum Industrie 4.0 Potsdam (ZIP 4.0) kann diese Frage individuell und ohne großen Aufwand beantwortet werden. Mehr noch, mit Hilfe der hybriden Simulationsumgebung ist die Interaktion mit dem AR-Gerät durch den Akteur innerhalb von Fertigungsprozessen möglich. So kann nicht nur der Nutzen demonstriert, sondern auch durch den tatsächlichen Einsatz innerhalb der realitätsnahen Prozessabbildung die Akzeptanz für die spätere Nutzung geschaffen werden.
Y1  - 2020
U6  - https://doi.org/10.30844/FS20-4_32-33
SN  - 2569-7692
VL  - 25
IS  - 4
SP  - 32
EP  - 33
PB  - GITO mbH - Verlag für Industrielle Informationstechnik und Organisation
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ohlert, Clemens
A1  - Boos, Pauline
T1  - Auswirkungen der Digitalisierung auf Geschlechterungleichheiten
T1  - Digital transformation and gender inequality
BT  - eine empirische Untersuchung auf Branchenebene
BT  - an empirical analysis at the sector level
JF  - Arbeit
N2  - Ausgehend von der Debatte um die Genderaspekte der Digitalisierung der Arbeit untersuchen wir den Zusammenhang zwischen der Nutzung digitaler Technologien und der Entwicklung von Geschlechterungleichheiten empirisch. Die Ergebnisse zeigen, dass Frauen in Branchen mit hohem Digitalisierungsgrad unterrepräsentiert sind und dass sich diese Dimension der Geschlechtersegregation in den letzten Jahren verstärkte. Die Unterrepräsentation von Frauen in Branchen mit hohem Digitalisierungsgrad geht mit Nachteilen bei den Verdiensten einher. Die Ergebnisse zeigen zudem, dass der Gender Pay Gap in Branchen mit hohem Digitalisierungsgrad tendenziell größer ist und über die Zeit weniger zurückging als in Branchen, in denen weniger digitale Technologien genutzt werden.
N2  - Departing from previously discussed gender aspects of digitalization, we empirically investigate the relation between the use of digital technologies and the evolution of gender inequalities. The results show that women are underrepresented in sectors which apply more digital technologies and that this segregation has increased in the past years. The underrepresentation of women in sectors with a higher degree of digital technology usage goes along with lower wages. The results further show that the Gender Pay Gap is larger and more persistent in sectors with a higher degree of digital technology usage than in sectors with less intense technology application.
KW  - Digitalisierung
KW  - Geschlechtersegregation
KW  - Gender Pay Gap
KW  - digital transformation
KW  - gender segregation
KW  - gender pay gap
Y1  - 2020
U6  - https://doi.org/10.1515/arbeit-2020-0015
SN  - 0941-5025
SN  - 2365-984X
VL  - 29
IS  - 3-4
SP  - 195
EP  - 218
PB  - De Gruyter Oldenbourg
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Deutschmann, Claudia
A1  - Roggenbuck, Dirk
A1  - Schierack, Peter
A1  - Rödiger, Stefan
T1  - Autoantibody testing by enzyme-linked immunosorbent assay-a case in which the solid phase decides on success and failure
JF  - Heliyon
N2  - Background: The enzyme-linked immunosorbent assay (ELISA) is an indispensable tool for clinical diagnostics to identify or differentiate diseases such as autoimmune illnesses, but also to monitor their progression or control the efficacy of drugs. One use case of ELISA is to differentiate between different states (e.g. healthy vs. diseased). Another goal is to quantitatively assess the biomarker in question, like autoantibodies. Thus, the ELISA technology is used for the discovery and verification of new autoantibodies, too. Of key interest, however, is the development of immunoassays for the sensitive and specific detection of such biomarkers at early disease stages. Therefore, users have to deal with many parameters, such as buffer systems or antigen-autoantibody interactions, to successfully establish an ELISA. Often, fine-tuning like testing of several blocking substances is performed to yield high signal-to-noise ratios. <br /> Methods: We developed an ELISA to detect IgA and IgG autoantibodies against chitinase-3-like protein 1 (CHI3L1), a newly identified autoantigen in inflammatory bowel disease (IBD), in the serum of control and disease groups (n = 23, respectively). Microwell plates with different surface modifications (PolySorp and MaxiSorp coating) were tested to detect reproducibility problems. <br /> Results: We found a significant impact of the surface properties of the microwell plates. IgA antibody reactivity was significantly lower, since it was in the range of background noise, when measured on MaxiSorp coated plates (p < 0.0001). The IgG antibody reactivity did not differ on the diverse plates, but the plate surface had a significant influence on the test result (p = 0.0005). <br /> Conclusion: With this report, we want to draw readers' attention to the properties of solid phases and their effects on the detection of autoantibodies by ELISA. We want to sensitize the reader to the fact that the choice of the wrong plate can lead to a false negative test result, which in turn has serious consequences for the discovery of autoantibodies.
KW  - biochemistry
KW  - coatings
KW  - surface chemistry
KW  - immunology
KW  - proteins
KW  - laboratory medicine
KW  - clinical research
KW  - enzyme-linked immunosorbent
KW  - assay
KW  - biomarker discovery
KW  - reproducibility
KW  - solid-phase
KW  - autoantibody
Y1  - 2020
U6  - https://doi.org/10.1016/j.heliyon.2020.e03270
SN  - 2405-8440
VL  - 6
IS  - 1
PB  - Elsevier
CY  - London [u.a.]
ER  - 
TY  - JOUR
A1  - Stede, Manfred
T1  - Automatic argumentation mining and the role of stance and sentiment
JF  - Journal of argumentation in context
N2  - Argumentation mining is a subfield of Computational Linguistics that aims (primarily) at automatically finding arguments and their structural components in natural language text. We provide a short introduction to this field, intended for an audience with a limited computational background. After explaining the subtasks involved in this problem of deriving the structure of arguments, we describe two other applications that are popular in computational linguistics: sentiment analysis and stance detection. From the linguistic viewpoint, they concern the semantics of evaluation in language. In the final part of the paper, we briefly examine the roles that these two tasks play in argumentation mining, both in current practice, and in possible future systems.
KW  - argumentation structure
KW  - argumentation mining
KW  - sentiment analysis
KW  - stance detection
Y1  - 2020
U6  - https://doi.org/10.1075/jaic.00006.ste
SN  - 2211-4742
SN  - 2211-4750
VL  - 9
IS  - 1
SP  - 19
EP  - 41
PB  - John Benjamins Publishing Co.
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schinköth, Michaela
A1  - Brand, Ralf
T1  - Automatic associations and the affective valuation of exercise
BT  - disentangling the type-1 process of the affective–reflective theory of physical inactivity and exercise
JF  - German Journal of Exercise and Sport Research
N2  - The decision to exercise is not only bound to rational considerations but also automatic affective processes. The affective–reflective theory of physical inactivity and exercise (ART) proposes a theoretical framework for explaining how the automatic affective process (type‑1 process) will influence exercise behavior, i.e., through the automatic activation of exercise-related associations and a subsequent affective valuation of exercise. This study aimed to empirically test this assumption of the ART with data from 69 study participants. A single-measurement study, including within-subject experimental variation, was conducted. Automatic associations with exercise were first measured with a single-target implicit association test. The somato-affective core of the participants’ automatic valuation of exercise-related pictures was then assessed via heart rate variability (HRV) analysis, and the affective valence of the valuation was tested with a facial expression (FE; smile and frown) task. Exercise behavior was assessed via self-report. Multiple regression (path) analysis revealed that automatic associations predicted HRV reactivity (β = −0.24, p = .044); the signs of the correlation between automatic associations and the smile FE score was in the expected direction but remained nonsignificant (β = −0.21, p = .078). HRV reactivity predicted self-reported exercise behavior (β = −0.28, p = .013) (the same pattern of results was achieved for the frown FE score). The HRV-related results illustrate the potential role of automatic negative affective reactions to the thought of exercise as a restraining force in exercise motivation. For better empirical distinction between the two ART type‑1 process components, automatic associations and the affective valuation should perhaps be measured separately in the future. The results support the notion that automatic and affective processes should be regarded as essential aspects of the motivation to exercise.
KW  - Heart rate variability
KW  - Facial expression
KW  - Somatic
KW  - Dual-process
KW  - Motivation
Y1  - 2019
U6  - https://doi.org/10.1007/s12662-020-00664-9
SN  - 2509-3150
SN  - 2509-3142
VL  - 50
IS  - 654
SP  - 366
EP  - 376
PB  - Springer
CY  - Berlin ; Heidelberg
ER  - 
TY  - JOUR
A1  - Gwozdz, Patricia Aneta
ED  - Willer, Stefan
ED  - Keller, Andreas
T1  - Autopoiesis als Modell interdiskursive Selbstübersetzung
BT  - Wissenstransfer bei Maturana, Varela und Luhmann
JF  - Selbstübersetzung als Wissenstransfer
Y1  - 2020
SN  - 978-3-86599-467-7
SP  - 279
EP  - 302
PB  - Kadmos
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Gwozdz, Patricia Aneta
ED  - Willer, Stefan
ED  - Keller, Andreas
T1  - Autopoiesis als Modell interdiskursive Selbstübersetzung
BT  - Wissenstransfer bei Maturana, Varela und Luhmann
JF  - Selbstübersetzung als Wissenstransfer
KW  - Niklas Luhmann
KW  - Humberto Maturana
KW  - Autopoiesis
KW  - Übersetzung
KW  - Interdiskurs
KW  - Wissenschaftskommunikation
Y1  - 2020
SN  - 978-3-86599-467-7
SP  - 279
EP  - 301
PB  - Kadmos
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Liese, Andrea
T1  - Autorität in den internationalen Beziehungen
JF  - Zeitschrift für internationale Beziehungen
N2  - Der Beitrag setzt sich würdigend und kritisch mit Michael Zürns Arbeiten zur internationalen Autorität auseinander. Dessen potenziell autoritatives Autoritätskonzept weist mehrere Vorzüge auf: Erstens bietet es eine Erklärung für ein Paradox. Warum sollten souveräne Staaten die Kompetenz Externer anerkennen, ihnen Ratschläge zu geben bzw. Forderungen an sie zu richten, und zudem noch bereit sein, diesen zu folgen? Zweitens konkretisiert es die u.a. bei Hannah Arendt angelegte Idee der fraglosen Anerkennung, indem es Autoritätsadressaten zugesteht, bestimmte Qualitäten der Autorität zu prüfen. Drittens entkoppelt es Legitimität und Autorität, ohne die Legitimationsbedürftigkeit von Autorität zu opfern. Dies anerkennend plädiert der Beitrag aber dafür, die Legitimationsbedürftigkeit internationaler Autorität nicht auf formal institutionalisierte Beziehungen zu reduzieren, sondern diese auch weiterhin auf informellere, d.h. der Praxis entstammende, Anerkennung und Folgebereitschaft innerhalb von Autoritätsbeziehungen zu beziehen. Die überzeugende begründungstheoretische Fundierung von Autorität sollte zudem nicht dazu verführen, Sozialisationsprozesse in Autoritätsbeziehungen zu übersehen, zumal deren Legitimität kritisch hinterfragbar ist.
Y1  - 2020
U6  - https://doi.org/10.5771/0946-7165-2020-1-97
SN  - 0946-7165
SN  - 2942-1233
VL  - 27
IS  - 1
SP  - 97
EP  - 109
PB  - Nomos
CY  - Baden-Baden
ER  - 
TY  - JOUR
A1  - McDowell, Michelle
A1  - Pachur, Thorsten
T1  - Availability, affect, and decisions to seek information about cancer risks
JF  - Medical decision making : MDM
N2  - How do people decide which risks they want to get informed about? The present study examines the role of the availability and affect heuristics on these decisions. Participants (N= 100, aged 19-72 years) selected for which of 23 cancers they would like to receive an information brochure, reported the number of occurrences of each type of cancer in their social circle (availability), and rated their dread reaction to each type of cancer (affect); they also made relative judgments about which of 2 cancers was more common in Germany (judged risk). Participants tended to choose information brochures for those cancers for which they indicated a higher availability within their social networks as well as for cancers they dreaded. Mediation analyses suggested that the influence of availability and affect on information choice was only partly mediated by judged risk. The results demonstrate the operation of 2 key judgment heuristics (availability and affect), previously studied in risk perception, also in decisions about information choice. We discuss how our findings can be used to identify which risks are likely to fall from people's radar.
KW  - information seeking
KW  - risk perception
Y1  - 2020
U6  - https://doi.org/10.1177/0272989X20951775
SN  - 0272-989X
SN  - 1552-681X
VL  - 40
IS  - 8
SP  - 941
EP  - 945
PB  - Sage Publ.
CY  - Thousand Oaks
ER  - 
TY  - JOUR
A1  - Gebel, Arnd
A1  - Lehmann, Tim
A1  - Granacher, Urs
T1  - Balance task difficulty affects postural sway and cortical activity in healthy adolescents
JF  - Experimental brain research
N2  - Electroencephalographic (EEG) research indicates changes in adults' low frequency bands of frontoparietal brain areas executing different balance tasks with increasing postural demands. However, this issue is unsolved for adolescents when performing the same balance task with increasing difficulty. Therefore, we examined the effects of a progressively increasing balance task difficulty on balance performance and brain activity in adolescents. Thirteen healthy adolescents aged 16-17 year performed tests in bipedal upright stance on a balance board with six progressively increasing levels of task difficulty. Postural sway and cortical activity were recorded simultaneously using a pressure sensitive measuring system and EEG. The power spectrum was analyzed for theta (4-7 Hz) and alpha-2 (10-12 Hz) frequency bands in pre-defined frontal, central, and parietal clusters of electrocortical sources. Repeated measures analysis of variance (rmANOVA) showed a significant main effect of task difficulty for postural sway (p < 0.001; d = 6.36). Concomitantly, the power spectrum changed in frontal, bilateral central, and bilateral parietal clusters. RmANOVAs revealed significant main effects of task difficulty for theta band power in the frontal (p < 0.001, d = 1.80) and both central clusters (left: p < 0.001, d = 1.49; right: p < 0.001, d = 1.42) as well as for alpha-2 band power in both parietal clusters (left: p < 0.001, d = 1.39; right: p < 0.001, d = 1.05) and in the central right cluster (p = 0.005, d = 0.92). Increases in theta band power (frontal, central) and decreases in alpha-2 power (central, parietal) with increasing balance task difficulty may reflect increased attentional processes and/or error monitoring as well as increased sensory information processing due to increasing postural demands. In general, our findings are mostly in agreement with studies conducted in adults. Similar to adult studies, our data with adolescents indicated the involvement of frontoparietal brain areas in the regulation of postural control. In addition, we detected that activity of selected brain areas (e.g., bilateral central) changed with increasing postural demands.
KW  - balance
KW  - postural control
KW  - EEG
KW  - Theta
KW  - Alpha-2
KW  - ICA
KW  - youth
Y1  - 2020
U6  - https://doi.org/10.1007/s00221-020-05810-1
SN  - 0014-4819
SN  - 1432-1106
VL  - 238
IS  - 5
SP  - 1323
EP  - 1333
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Marszałek, Magdalena
T1  - Barde der konservativen Revolution
BT  - Jarosław Marek Rymkiewicz
JF  - Osteuropa
N2  - Die konservative Revolution in Polen hat ihre Thinktanks, Intellektuellen und ihre Literatur. Jarosław Marek Rymkiewicz genießt in rechten Kreisen den Status eines Nationaldichters. Bereits in den frühen 1990ern schloss sich Rymkiewicz den radikalen Kritikern der polnischen Transformation an. Er gehört zu den prominenten Unterstützern der PiS. Sein literarisch fesselndes und politisch brisantes Spätwerk übt großen Einfluss auf die Radikalkonservativen in Polen aus.
KW  - Polen
KW  - Literatur
KW  - konservative Revolution
KW  - Nationalismus
KW  - Poland
KW  - fiction
KW  - poetry
KW  - conservative revolution
KW  - nationalism
Y1  - 2020
U6  - https://doi.org/10.35998/oe-2020-0022
SN  - 0030-6428
SN  - 2509-3444
VL  - 70
IS  - 3-4
SP  - 143
EP  - 161
PB  - Berliner Wissenschafts-Verlag
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Tranter, Morgan Alan
A1  - De Lucia, Marco
A1  - Wolfgramm, Markus
A1  - Kühn, Michael
T1  - Barite scale formation and injectivity loss models for geothermal systems
JF  - Water
N2  - Barite scales in geothermal installations are a highly unwanted effect of circulating deep saline fluids. They build up in the reservoir if supersaturated fluids are re-injected, leading to irreversible loss of injectivity. A model is presented for calculating the total expected barite precipitation. To determine the related injectivity decline over time, the spatial precipitation distribution in the subsurface near the injection well is assessed by modelling barite growth kinetics in a radially diverging Darcy flow domain. Flow and reservoir properties as well as fluid chemistry are chosen to represent reservoirs subject to geothermal exploration located in the North German Basin (NGB) and the Upper Rhine Graben (URG) in Germany. Fluids encountered at similar depths are hotter in the URG, while they are more saline in the NGB. The associated scaling amount normalised to flow rate is similar for both regions. The predicted injectivity decline after 10 years, on the other hand, is far greater for the NGB (64%) compared to the URG (24%), due to the temperature- and salinity-dependent precipitation rate. The systems in the NGB are at higher risk. Finally, a lightweight score is developed for approximating the injectivity loss using the Damkohler number, flow rate and total barite scaling potential. This formula can be easily applied to geothermal installations without running complex reactive transport simulations.
KW  - reactive transport
KW  - radial flow
KW  - geothermal energy
KW  - scaling
KW  - phreeqc
KW  - formation damage
Y1  - 2020
U6  - https://doi.org/10.3390/w12113078
SN  - 2073-4441
VL  - 12
IS  - 11
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Perdigón-Toro, Lorena
A1  - Zhang, Huotian
A1  - Markina, Anastaa si
A1  - Yuan, Jun
A1  - Hosseini, Seyed Mehrdad
A1  - Wolff, Christian Michael
A1  - Zuo, Guangzheng
A1  - Stolterfoht, Martin
A1  - Zou, Yingping
A1  - Gao, Feng
A1  - Andrienko, Denis
A1  - Shoaee, Safa
A1  - Neher, Dieter
T1  - Barrierless free charge generation in the high-performance PM6:Y6 bulk heterojunction non-fullerene solar cell
JF  - Advanced materials
N2  - Organic solar cells are currently experiencing a second golden age thanks to the development of novel non-fullerene acceptors (NFAs). Surprisingly, some of these blends exhibit high efficiencies despite a low energy offset at the heterojunction. Herein, free charge generation in the high-performance blend of the donor polymer PM6 with the NFA Y6 is thoroughly investigated as a function of internal field, temperature and excitation energy. Results show that photocurrent generation is essentially barrierless with near-unity efficiency, regardless of excitation energy. Efficient charge separation is maintained over a wide temperature range, down to 100 K, despite the small driving force for charge generation. Studies on a blend with a low concentration of the NFA, measurements of the energetic disorder, and theoretical modeling suggest that CT state dissociation is assisted by the electrostatic interfacial field which for Y6 is large enough to compensate the Coulomb dissociation barrier.
KW  - driving force
KW  - non-fullerene acceptors
KW  - organic solar cells
KW  - photocurrent generation
Y1  - 2020
U6  - https://doi.org/10.1002/adma.201906763
SN  - 0935-9648
SN  - 1521-4095
VL  - 32
IS  - 9
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Maier, Corinna
A1  - Hartung, Niklas
A1  - de Wiljes, Jana
A1  - Kloft, Charlotte
A1  - Huisinga, Wilhelm
T1  - Bayesian Data Assimilation to Support Informed Decision Making in Individualized Chemotherapy
JF  - CPT: Pharmacometrics & Systems Pharmacology
N2  - An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayesian forecasting tools typically rely only on the most probable model parameters (maximum a posteriori (MAP) estimate). This MAP-based approach, however, does neither necessarily predict the most probable outcome nor does it quantify the risks of treatment inefficacy or toxicity. Bayesian data assimilation (DA) methods overcome these limitations by providing a comprehensive uncertainty quantification. We compare DA methods with MAP-based approaches and show how probabilistic statements about key markers related to chemotherapy-induced neutropenia can be leveraged for more informative decision support in individualized chemotherapy. Sequential Bayesian DA proved to be most computationally efficient for handling interoccasion variability and integrating TDM data. For new digital monitoring devices enabling more frequent data collection, these features will be of critical importance to improve patient care decisions in various therapeutic areas.
KW  - Induced neutropenia
KW  - Model
KW  - Myelosuppression
KW  - Prediction
Y1  - 2019
U6  - https://doi.org/10.1002/psp4.12492
SN  - 2163-8306
VL  - XX
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Korup, Oliver
T1  - Bayesian geomorphology
JF  - Earth surface processes and landforms : the journal of the British Geomorphological Research Group
N2  - The rapidly growing amount and diversity of data are confronting us more than ever with the need to make informed predictions under uncertainty. The adverse impacts of climate change and natural hazards also motivate our search for reliable predictions. The range of statistical techniques that geomorphologists use to tackle this challenge has been growing, but rarely involves Bayesian methods. Instead, many geomorphic models rely on estimated averages that largely miss out on the variability of form and process. Yet seemingly fixed estimates of channel heads, sediment rating curves or glacier equilibrium lines, for example, are all prone to uncertainties. Neighbouring scientific disciplines such as physics, hydrology or ecology have readily embraced Bayesian methods to fully capture and better explain such uncertainties, as the necessary computational tools have advanced greatly. The aim of this article is to introduce the Bayesian toolkit to scientists concerned with Earth surface processes and landforms, and to show how geomorphic models might benefit from probabilistic concepts. I briefly review the use of Bayesian reasoning in geomorphology, and outline the corresponding variants of regression and classification in several worked examples.
KW  - Bayes' rule
KW  - probability
KW  - uncertainty
KW  - prediction
Y1  - 2020
U6  - https://doi.org/10.1002/esp.4995
SN  - 0197-9337
SN  - 1096-9837
VL  - 46
IS  - 1
SP  - 151
EP  - 172
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Seelig, Stefan A.
A1  - Rabe, Maximilian Michael
A1  - Malem-Shinitski, Noa
A1  - Risse, Sarah
A1  - Reich, Sebastian
A1  - Engbert, Ralf
T1  - Bayesian parameter estimation for the SWIFT model of eye-movement control during reading
JF  - Journal of mathematical psychology
N2  - Process-oriented theories of cognition must be evaluated against time-ordered observations. Here we present a representative example for data assimilation of the SWIFT model, a dynamical model of the control of fixation positions and fixation durations during natural reading of single sentences. First, we develop and test an approximate likelihood function of the model, which is a combination of a spatial, pseudo-marginal likelihood and a temporal likelihood obtained by probability density approximation Second, we implement a Bayesian approach to parameter inference using an adaptive Markov chain Monte Carlo procedure. Our results indicate that model parameters can be estimated reliably for individual subjects. We conclude that approximative Bayesian inference represents a considerable step forward for computational models of eye-movement control, where modeling of individual data on the basis of process-based dynamic models has not been possible so far.
KW  - dynamical models
KW  - reading
KW  - eye movements
KW  - saccades
KW  - likelihood function
KW  - Bayesian inference
KW  - MCMC
KW  - interindividual differences
Y1  - 2020
U6  - https://doi.org/10.1016/j.jmp.2019.102313
SN  - 0022-2496
SN  - 1096-0880
VL  - 95
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Lettl, Tobias
T1  - BB-Rechtsprechungsreport zum Wettbewerbsrecht 2019/2020
JF  - Betriebs-Berater
N2  - Anknüpfend an den BB-Rechtsprechungsreport zum Wettbewerbsrecht 2018/2019, BB 2019,  2499 ff., gibt der Autor im folgenden Beitrag eine Übersicht über die Entwicklung der Rechtsprechung von EuGH und BGH zum Wettbewerbsrecht (Lauterkeitsrecht) im vergangenen Jahr.
Y1  - 2020
UR  - https://www.juris.de/perma?d=jzs-BB-2020-43-2375-2380-1
SN  - 0340-7918
VL  - 43
SP  - 2375
EP  - 2380
PB  - dfv-Mediengruppe
CY  - Frankfurt am Main
ER  - 
TY  - JOUR
A1  - Moffitt, Ursula E.
A1  - Nardon, Luciara
A1  - Zhang, Hui
T1  - Becoming Canadian
BT  - immigrant narratives of professional attainment
JF  - International journal of intercultural relations
N2  - We investigate how economic immigrants in Canada negotiate their identity in the process of "becoming Canadian" through an analysis of public texts. Drawing on the master narrative framework, we examine the interplay between individual and societal narratives as immigrants grapple with the tension between notions of "desirable" immigrants as those that are well integrated professionally and the reality of facing career related barriers. Among those whose success stories align with the master narrative of professional attainment there was little questioning of this expectation, thereby allowing it to remain invisible. Among those who had not (yet) achieved work related success in the receiving country, they tended to engage alternative narratives elaborating on the antecedents, outcomes, and barriers to labor market participation. Despite the countering nature of these alternative narratives, they strengthen the societal expectation of professional success as a key pathway to inclusion, thereby reinforcing the rigidity of this narrative. We contribute to literature on the social construction of national identity by examining the process of becoming national and the role of labor market participation in immigrants' perceptions of inclusion in their new society. Our study highlights the importance of including immigrants' voices in the construction of a more inclusive society, which may aid in breaking down exclusionary narratives of national identity.
KW  - inclusion
KW  - national identity
KW  - identity work
KW  - markers of inclusion
KW  - immigrants
KW  - master narratives
Y1  - 2020
U6  - https://doi.org/10.1016/j.ijintrel.2019.06.004
SN  - 0147-1767
SN  - 1873-7552
VL  - 78
SP  - 84
EP  - 95
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Bethge, Anita
A1  - Hanne, Sandra
A1  - Stadie, Nicole
T1  - Behandlung von Wortabrufstörungen bei Probanden mit Alzheimer Demenz
BT  - Semantische Komplexität und Wortflüssigkeit
JF  - Spektrum Patholinguistik
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469589
SN  - 978-3-86956-479-1
SN  - 1866-9085
SN  - 1866-9433
IS  - 12
SP  - 169
EP  - 179
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Dech, Silas
A1  - Bittmann, Frank
A1  - Schaefer, Laura
T1  - Behavior of oxygen saturation and blood filling in the venous capillary system of the biceps brachii muscle during a fatiguing isometric action
JF  - European Journal of Translational Myology
N2  - The objective of the study is to develop a better understanding of the capillary circulation in contracting muscles. Ten subjects were measured during a submaximal fatiguing isometric muscle action by use of the O2C spectrophotometer. In all measurements the capillary-venous oxygen saturation of hemoglobin (SvO2) decreases immediately after the start of loading and levels off into a steady state. However, two different patterns (type I and type II) emerged. They differ in the extent of deoxygenation (–10.37 ±2.59 percent points (pp) vs. –33.86 ±17.35 pp, P = .008) and the behavior of the relative hemoglobin amount (rHb). Type I reveals a positive rank correlation of SvO2 and rHb (? = 0.735, P <.001), whereas a negative rank correlation (? = –0.522, P <.001) occurred in type II, since rHb decreases until a reversal point, then increases averagely 13% above the baseline value and levels off into a steady state. The results reveal that a homeostasis of oxygen delivery and consumption during isometric muscle actions is possible. A rough distinction in two types of regulation is suggested.
KW  - muscle oxygenation
KW  - hemoglobin amount
KW  - isometric muscle action
KW  - O2C spectrophotometer
Y1  - 2020
U6  - https://doi.org/10.4081/ejtm.2019.8800
SN  - 2037-7460
VL  - 30
IS  - 1
SP  - 79
EP  - 87
PB  - Unipress
CY  - Padova
ER  - 
TY  - JOUR
A1  - Dwi Putra, Sulistyo Emantoko
A1  - Reichetzeder, Christoph
A1  - Hasan, Ahmed Abdallah Abdalrahman Mohamed
A1  - Slowinski, Torsten
A1  - Chu, Chang
A1  - Krämer, Bernhard K.
A1  - Kleuser, Burkhard
A1  - Hocher, Berthold
T1  - Being born large for gestational age is associated with increased global placental DNA methylation
JF  - Scientific Reports
N2  - Being born small (SGA) or large for gestational age (LGA) is associated with adverse birth outcomes and metabolic diseases in later life of the offspring. It is known that aberrations in growth during gestation are related to altered placental function. Placental function is regulated by epigenetic mechanisms such as DNA methylation. Several studies in recent years have demonstrated associations between altered patterns of DNA methylation and adverse birth outcomes. However, larger studies that reliably investigated global DNA methylation are lacking. The aim of this study was to characterize global placental DNA methylation in relationship to size for gestational age. Global DNA methylation was assessed in 1023 placental samples by LC-MS/MS. LGA offspring displayed significantly higher global placental DNA methylation compared to appropriate for gestational age (AGA; p<0.001). ANCOVA analyses adjusted for known factors impacting on DNA methylation demonstrated an independent association between placental global DNA methylation and LGA births (p<0.001). Tertile stratification according to global placental DNA methylation levels revealed a significantly higher frequency of LGA births in the third tertile. Furthermore, a multiple logistic regression analysis corrected for known factors influencing birth weight highlighted an independent positive association between global placental DNA methylation and the frequency of LGA births (p=0.001).
KW  - fetal origins hypothesis
KW  - birth weight
KW  - repetitive elements
KW  - glucocorticoid receptor
KW  - nutrient transport
KW  - growth restriction
KW  - later health
KW  - pregnancy
KW  - genes
KW  - patterns
Y1  - 2020
U6  - https://doi.org/10.1038/s41598-020-57725-0
SN  - 2045-2322
VL  - 10
IS  - 1
SP  - 1
EP  - 10
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Kleinpeter, Erich
A1  - Koch, Andreas
T1  - Bent Allenes or Di-1,3-betaines-An Answer Given on the Magnetic Criterion
JF  - The journal of physical chemistry : A, Molecules, spectroscopy, kinetics, environment & general theory
N2  - The spatial magnetic properties, through-space NMR shieldings (TSNMRS), of bent allene 1, the corresponding C-extended 1,3-butadiene derivative 2, and a number of related compounds 3 -20 have been calculated using the gauge-independent atomic orbital perturbation method, employing the nucleus-independent chemical shift concept and visualized as isochemical shielding surfaces of various sizes and directions. Prior to that, both structures and C-13 chemical shifts were calculated and compared with available experimental bond lengths and delta(C-13)/ppm values (also, as a quality criterion for the computed structures). Bond lengths, the delta(C-13)/ppm, and the TSNMRS values are employed to qualify and quantify the electronic structure of the studied compounds in terms of dative or classical electron-sharing bonds.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.jpca.0c01392
SN  - 1089-5639
SN  - 1520-5215
VL  - 124
IS  - 16
SP  - 3180
EP  - 3190
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Wagner, Marlene
T1  - Bericht über die Tätigkeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2019 – Teil I: Staatenberichte
JF  - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-471293
IS  - 25
SP  - 42
EP  - 69
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Wagner, Marlene
T1  - Bericht über die Tätigkeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2019 – Teil II: Individualbeschwerden
JF  - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-498672
VL  - 25
IS  - 2
SP  - 142
EP  - 156
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Steinrötter, Björn
A1  - Bohlsen, Stefan
T1  - Beschränkung des Sicherungsumfangs im Reiseinsolvenzrecht
JF  - Zeitschrift für Rechtspolitik
N2  - Der Beitrag befasst sich mit der Frage, ob und inwieweit es bei der Insolvenz von Reiseveranstaltern eine Begrenzung der Insolvenzabsicherungspflicht geben sollte – eine Problematik, die sich durch die Insolvenz von Thomas Cook zuletzt deutlich verschärft hat und die im Zuge der „Coronakrise“ erneut virulent geraten könnte. Die Verfasser argumentieren vor dem Hintergrund der Richtlinienwidrigkeit der deutschen lex lata für eine ersatzlose Streichung der Haftungshöchstsumme.
Y1  - 2020
UR  - https://beck-online.beck.de/Bcid/Y-300-Z-ZRP-B-2020-S-105-N-1
SN  - 0514-6496
VL  - 53
IS  - 4
SP  - 105
EP  - 108
PB  - C.H. Beck
CY  - München
ER  - 
TY  - JOUR
A1  - Ullrich, André
A1  - Gronau, Norbert
T1  - Bestimmung nachhaltiger Anwendungssystemarchitekturen
JF  - ERP-Management : Auswahl, Einführung und Betrieb von ERP-Systemen
N2  - Die teilweise sehr kurzfristig notwendige Reaktion auf Veränderungen erfordert von Unternehmen ein hohes Maß an Flexibilität und Reaktionsgeschwindigkeit. Anwendungssystemarchitekturen, die im Wesentlichen aus alten und selbst entwickelten Systemen bestehen, erfüllen häufig diese Anforderungen nicht. Investitionsmittel für neue Software sind jedoch begrenzt, daher müssen Prioritäten in der Ablösung von Altsystemen gesetzt werden. Eine effiziente Analysemethode zur Planung der Erneuerung der Anwendungssystemlandschaft stellt die Wandlungsfähigkeitsanalyse dar. Dieser Beitrag beschreibt Vorgehen und Ergebnisse am Beispiel eines international tätigen Automobilzulieferers.
N2  - The sometimes necessary reaction to changes requires a high degree of adaptability and speed of reaction from companies. Application system architectures, which essentially consist of old and self-developed systems, often do not meet these requirements. However, investment funds for new software are limited, so priorities must be set in the replacement of old systems. An efficient analysis method for planning the renewal of the application system landscape is the adaptability analysis. This article describes the procedure and results using the example of an internationally active automotive supplier.
KW  - Anpassungsfähigkeit
KW  - Anwendungssystemarchitekturen
KW  - Bewertung
KW  - adaptability
KW  - application system architectures
KW  - assessment
Y1  - 2020
UR  - https://www.wiso-net.de/document/ERP__1ba9f709bedd19d76acba5daebbc08c9befe5b9f
U6  - https://doi.org/10.30844/ERP_20-1_54-57
SN  - 1860-6725
VL  - 16
IS  - 1
SP  - 54
EP  - 57
PB  - GITO mbH
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Bohlsen, Stefan
T1  - Beurkundung der Auflassung durch Notar mit Amtssitz in der Schweiz
JF  - Zeitschrift für das Privatrecht der Europäischen Union
Y1  - 2020
U6  - https://doi.org/10.9785/gpr-2020-170504
SN  - 2364-7205
SN  - 2364-7213
VL  - 17
IS  - 5
SP  - 213
EP  - 217
PB  - Verlag Dr. Otto Schmidt
CY  - Köln
ER  - 
TY  - JOUR
A1  - Bangeow, Petjo
A1  - Rapp, Michael A.
T1  - Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie
T1  - Assessment and use of 2016 reformed psychotherapeutic guideline
BT  - Teil II : Ost-West- und Stadt-Land-Vergleich
BT  - part II : comparing Eastern and Western Germany as well as urban and rural areas
JF  - Psychiatrische Praxis : Sozialpsychiatrie, klinische Psychiatrie, public mental health, Versorgungsforschung
N2  - Ziel der Studie Dieser Artikel untersucht, inwiefern sich die 2016 reformierte Richtlinie im Stadt-Land- sowie im Ost-West-Vergleich auf die ambulante psychotherapeutische Arbeit und Versorgung auswirkt.
Methodik Eine Onlineumfrage unter vertragsärztlich tätigen TherapeutInnen wurde durchgeführt. Die Fragen bezogen sich auf verschiedene Neuerungen in der Richtlinie.
Ergebnisse Unabhängig von der Region schätzten die Befragten ein, dass die Reform zu keiner verbesserten Versorgung führte.
Im Westen und in der Stadt tätige TherapeutInnen verwiesen PatientInnen nach der Sprechstunde öfter an andere Psychotherapiepraxen, im Osten und auf dem Land tätige hingegen öfter auf andere Hilfeangebote.
Schlussfolgerung Stärkere Anreize für die psychotherapeutische Tätigkeit auf dem Land sind zu schaffen. Abbaumaßnahmen der Ost-West-Ungleichheiten in der Versorgungsdichte scheinen nötig.
N2  - Objective This article investigated whether or not the reformed psychotherapeutic guideline had different effects on outpatient psychotherapeutic work and services comparing urban and rural areas as well as eastern and western Germany.
Methods An online survey of psychotherapists was conducted. The survey included questions on various innovations within the reformed guideline.
Results Regardless of region, therapists stated overall that the reform has not led to improved psychotherapeutic care.
Therapists in the West and in urban areas referred more patients to other psychotherapeutic practices after their consultation. Therapists in the East and in rural areas referred more patients to other institutions and services.
Conclusions Psychotherapeutic work in rural areas should be better incentivized. Interventions to reduce east-west inequalities in the density of service provision seem to be necessary.
KW  - Psychotherapierichtlinie
KW  - Ostdeutschland
KW  - Westdeutschland
KW  - Stadt-Land-Vergleich
KW  - psychotherapy guidelines
KW  - Eastern-Western Germany
KW  - urban-rural
KW  - comparison
Y1  - 2020
U6  - https://doi.org/10.1055/a-1045-9820
SN  - 0303-4259
SN  - 1439-0876
VL  - 47
IS  - 07
SP  - 383
EP  - 387
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Bangeow, Petjo
A1  - Rapp, Michael A.
T1  - Beurteilung und Nutzung der 2016 reformierten Psychotherapierichtlinie
BT  - Teil I: Vergleich unter den psychotherapeutischen Richtlinienverfahren
BT  - Part I: A Comparison of the Psychotherapeutic Methods
JF  - Psychiatrische Praxis
N2  - Objective This article investigates how aspects of 2016 reform of the German psychotherapeutic guideline were evaluated and used differently by therapists from three different psychotherapeutic treatment methods. <br /> Methods An online survey was conducted with 987 statutory health insurance approved therapists. The questionnaire focused on various innovations in the guideline. <br /> Results There were significant differences in the use of the broadened authority and of specific treatment services. There were also differences in the application for short-term and long-term psychotherapies as well as in the application to extend short to long-term psychotherapy. <br /> Conclusions Elements of the guideline should be evaluated in relation to the preferred treatment method. Aspects related to the psychotherapeutic work with patients seem to be especially significant.
N2  - Ziel der Studie Dieser Artikel untersucht, inwiefern Aspekte der 2016 reformierten Psychotherapierichtlinie aus Sicht der drei Richtlinienverfahren für die praktische Arbeit unterschiedlich bewertet und genutzt werden. <br /> Methodik Eine Onlineumfrage wurde unter vertragsärztlich tätigen PsychotherapeutInnen (n = 987) durchgeführt. Die Fragen bezogen sich auf die unterschiedlichen Neuerungen in der Psychotherapierichtlinie.
Ergebnisse Signifikante Unterschiede wurden u. a. in der Nutzung der erweiterten Befugnisse sowie in der Abrechnung bestimmter Leistungen deutlich. Die Gruppen unterschieden sich auch in der Beantragung von Behandlungskontingenten. <br /> Schlussfolgerung Es scheint sinnvoll, Elemente der Richtlinienreform aus der Sicht des bevorzugten Behandlungsverfahrens zu evaluieren. Jene Aspekte scheinen bedeutsam, die sich auf die unmittelbare Arbeit mit den PatientInnen beziehen.
T2  - Assessment and Use of 2016 Reformed Psychotherapeutic Guideline
KW  - Psychotherapierichtlinie
KW  - Richtlinienverfahren
KW  - Unterschiede
KW  - psychotherapy guideline
KW  - psychotherapy methods
KW  - differences
Y1  - 2020
U6  - https://doi.org/10.1055/a-1045-9801
SN  - 0303-4259
SN  - 1439-0876
VL  - 47
IS  - 3
SP  - 135
EP  - 141
PB  - Thieme
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Schwaab, Bernhard
A1  - Rauch, Bernhard
A1  - Völler, Heinz
A1  - Benzer, Werner
A1  - Schmid, Jean-Paul
T1  - Beyond randomised studies
BT  - recommendations for cardiac rehabilitation following repair of thoracic aortic aneurysm or dissection
JF  - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology
Y1  - 2020
U6  - https://doi.org/10.1177/2047487320936782
SN  - 2047-4873
SN  - 2047-4881
VL  - 28
IS  - 17
SP  - E17
EP  - E19
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Lettl, Tobias
T1  - Bezwecken und Bewirken einer Wettbewerbsbeschränkung nach Art. 101 Abs. 1 AEUV, § 1 GWB am Beispiel von Interbankenentgelten
BT  - zugleich Besprechung von EuGH, Urt. v. 2.4.2020 = WM 2020, 773
JF  - Wertpapier-Mitteilungen Teil 4, Zeitschrift für Wirtschafts- und Bankrecht
Y1  - 2020
UR  - https://www.wiso-net.de/document/WM__8EE14695C18BCFDC943EA67AEEEF862E
SN  - 0342-6971
SN  - 0342-698X
VL  - 74
IS  - 39
SP  - 1801
EP  - 1806
ER  - 
TY  - JOUR
A1  - Krochmalnik, Daniel
T1  - Bibelliebe
JF  - Lebensweg, religiöse Erziehung und Bildung : Religionspädagogik als Autobiographie ; Teilband 7
Y1  - 2020
SN  - 978-3-8260-7183-6
SP  - 163
EP  - 176
PB  - Königshausen & Neumann
CY  - Würzburg
ER  - 
TY  - JOUR
A1  - Ludwig, Joachim
A1  - Thomsen, Sarah
T1  - Bildungsprozesse von Teilnehmenden in Tanz-, Theater und Performance-Projekten
JF  - Kulturelle Bildung : theoretische Perspektiven, methodologische Herausforderungen und empirische
Y1  - 2020
SN  - 978-3-8309-4150-7
SN  - 978-3-8309-9150-2
U6  - https://doi.org/https://doi.org/10.31244/9783830991502
SP  - 265
EP  - 278
PB  - Waxmann
CY  - Münster
ER  - 
TY  - JOUR
A1  - Drago, Claudia
A1  - Pawlak, Julia
A1  - Weithoff, Guntram
T1  - Biogenic aggregation of small microplastics alters their ingestion by a common freshwater micro-invertebrate
JF  - Frontiers in Environmental Science
N2  - In recent years, increasing concerns have been raised about the environmental risk of microplastics in freshwater ecosystems. Small microplastics enter the water either directly or accumulate through disintegration of larger plastic particles. These particles might then be ingested by filter-feeding zooplankton, such as rotifers. Particles released into the water may also interact with the biota through the formation of aggregates, which might alter the uptake by zooplankton. In this study, we tested for size-specific aggregation of polystyrene microspheres and their ingestion by a common freshwater rotifer Brachionus calyciflorus. The ingestion of three sizes of polystyrene microspheres (MS) 1-, 3-, and 6-mu m was investigated. Each MS size was tested in combination with three different treatments: MS as the sole food intake, MS in association with food algae and MS aggregated with biogenic matter. After 72 h incubation in pre-filtered natural river water, the majority of the 1-mu m spheres occurred as aggregates. The larger the particles, the higher the relative number of single particles and the larger the aggregates. All particles were ingested by the rotifer following a Type-II functional response. The presence of algae did not influence the ingestion of the MS for all three sizes. The biogenic aggregation of microspheres led to a significant size-dependent alteration in their ingestion. Rotifers ingested more microspheres (MS) when exposed to aggregated 1- and 3-mu m MS as compared to single spheres, whereas fewer aggregated 6-mu m spheres were ingested. This indicates that the small particles when aggregated were in an effective size range for Brachionus, while the aggregated larger spheres became too large to be efficiently ingested. These observations provide the first evidence of a size- and aggregation-dependent feeding interaction between microplastics and rotifers. Microplastics when aggregated with biogenic particles in a natural environment can rapidly change their size-dependent availability. The aggregation properties of microplastics should be taken into account when performing experiments mimicking the natural environment.
KW  - microplastics ingestion
KW  - Brachionus calyciflorus
KW  - aggregation
KW  - microplastics
KW  - polystyrene
KW  - functional response
Y1  - 2020
U6  - https://doi.org/10.3389/fenvs.2020.574274
SN  - 2296-665X
VL  - 8
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Bastian, Philipp U.
A1  - Yu, Leixiao
A1  - de Guereñu Kurganova, Anna Lopez
A1  - Haag, Rainer
A1  - Kumke, Michael Uwe
T1  - Bioinspired confinement of upconversion nanoparticles for improved performance in aqueous solution
JF  - The journal of physical chemistry : C, Nanomaterials and interfaces
N2  - The resonance energy transfer (RET) from NaYF4:Yb,Er upconverting nanoparticles (UNCPs) to a dye (5-carboxytetramethylrhodamine (TAMRA)) was investigated by photoluminescence experiments and microscale thermophoresis (MST). The dye was excited via RET from the UCNPs which was excited in the near-infrared (NIR). The change of the dye diffusion speed (free vs coupled) was investigated by MST. RET shows significant changes in the decay times of the dye as well as of the UCNPs. MST reveals significant changes in the diffusion speed. A unique amphiphilic coating polymer (customized mussel protein (CMP) polymer) for UCNP surface coating was used, which mimics blood protein adsorption and mussel food protein adhesion to transfer the UCNP into the aqueous phase and to allow surface functionalization. The CMP provides very good water dispersibility to the UCNPs and minimizes ligand exchange and subsequent UCNP aging reactions because of the interlinkage of the CMP on the UCNP surface. Moreover, CMP provides N-3-functional groups for dick chemistry-based functionalization demonstrated with the dye 5-carboxytetramethylrhodamine (TAMRA). This establishes the principle coupling scheme for suitable biomarkers such as antibodies. The CMP provides very stable aqueous UCNP dispersions that are storable up to 3 years in a fridge at 5 degrees C without dissolution or coagulation. The outstanding properties of CMP in shielding the UCNP from unwanted solvent effects is reflected in the distinct increase of the photoluminescence decay times after UCNP functionalization. The UCNP-to-TAMRA energy transfer is also spectroscopically investigated at low temperatures (4-200 K), revealing that one of the two green Er(III) emission bands contributes the major part to the energy transfer. The TAMRA fluorescence decay time increases by a factor of 9500 from 2.28 ns up to 22 mu s due to radiationless energy transfer from the UCNP after NIR excitation of the latter. This underlines the unique properties of CMP as a versatile capping ligand for distinctly improving the UCNPs' performance in aqueous solutions, for coupling of biomolecules, and for applications for in vitro and in vivo experiments using UCNPs as optical probes in life science applications.
Y1  - 2020
U6  - https://doi.org/10.1021/acs.jpcc.0c09798
SN  - 1932-7447
SN  - 1932-7455
VL  - 124
IS  - 52
SP  - 28623
EP  - 28635
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Rehse, Jessica
T1  - BioShock 1 und BioShock 2
JF  - „Wir alle treffen Entscheidungen im Leben, aber letztendlich treffen unsere Entscheidungen uns.“ : didaktische Potenziale digitaler Spielwelten
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485626
SN  - 978-3-86956-489-0
SP  - 65
EP  - 83
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Rehse, Jessica
A1  - Riemer, Nathanael
T1  - BioShock Infinite
JF  - „Wir alle treffen Entscheidungen im Leben, aber letztendlich treffen unsere Entscheidungen uns.“ : didaktische Potenziale digitaler Spielwelten
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485659
SN  - 978-3-86956-489-0
SP  - 85
EP  - 106
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Heinzel, Mirko Noa
A1  - Richter, Jonas
A1  - Busch, Per-Olof
A1  - Feil, Hauke
A1  - Herold, Jana
A1  - Liese, Andrea
T1  - Birds of a feather?
BT  - the determinants of impartiality perceptions of the IMF and the World Bank
JF  - Review of international political economy
N2  - The International Monetary Fund and the World Bank ascribe to impartiality in their mandates. At the same time, scholarship indicates that their decisions are disproportionately influenced by powerful member states. Impartiality is seen as crucial in determining International Organizations' (IOs) effectiveness and legitimacy in the literature. However, we know little about whether key interlocutors in national governments perceive the International Financial Institutions as biased actors who do the bidding for powerful member states or as impartial executors of policy. In order to better understand these perceptions, we surveyed high-level civil servants who are chiefly responsible for four policy areas from more than 100 countries. We found substantial variations in impartiality perceptions. What explains these variations? By developing an argument of selective awareness, we extend rationalist and ideational perspectives on IO impartiality to explain domestic perceptions. Using novel survey data, we test whether staffing underrepresentation, voting underrepresentation, alignment to the major shareholders and overlapping economic policy paradigms are associated with impartiality perceptions. We find substantial evidence that shared economic policy paradigms influence impartiality perceptions. The findings imply that by diversifying their ideational culture, IOs can increase the likelihood that domestic stakeholders view them as impartial.
KW  - Impartiality
KW  - bias
KW  - International Financial Institutions
KW  - International
KW  - Monetary Fund
KW  - World Bank
Y1  - 2020
U6  - https://doi.org/10.1080/09692290.2020.1749711
SN  - 0969-2290
SN  - 1466-4526
VL  - 28
IS  - 5
SP  - 1249
EP  - 1273
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  - 
TY  - JOUR
A1  - Ramachandran, Srikanthan
A1  - Rupakheti, Maheswar
A1  - Lawrence, Mark
T1  - Black carbon dominates the aerosol absorption over the Indo-Gangetic Plain and the Himalayan foothills
JF  - Environment international : a journal of science, technology, health, monitoring and policy
N2  - This study, based on new and high quality in situ observations, quantifies for the first time, the individual contributions of light-absorbing aerosols (black carbon (BC), brown carbon (BrC) and dust) to aerosol absorption over the Indo-Gangetic Plain (IGP) and the Himalayan foothill region, a relatively poorly studied region with several sensitive ecosystems of global importance, as well as highly vulnerable populations. The annual and seasonal average single scattering albedo (SSA) over Kathmandu is the lowest of all the locations. The SSA over Kathmandu is < 0.89 during all seasons, which confirms the dominance of light-absorbing carbonaceous aerosols from local and regional sources over Kathmandu. It is observed here that the SSA decreases with increasing elevation, confirming the dominance of light absorbing carbonaceous aerosols at higher elevations. In contrast, the SSA over the IGP does not exhibit a pronounced spatial variation. BC dominates (>= 75%) the aerosol absorption over the IGP and the Himalayan foothills throughout the year. Higher BC concentration at elevated locations in the Himalayas leads to lower SSA at elevated locations in the Himalayas. The contribution of dust to aerosol absorption is higher throughout the year over the IGP than over the Himalayan foothills. The aerosol absorption over South Asia is very high, exceeding available observations over East Asia, and also exceeds previous model estimates. This quantification will be valuable as observational constraints to help improve regional simulations of climate change, impacts on the glaciers and the hydrological cycle, and will help to direct the focus towards BC as the main contributor to aerosol-induced warming in the region.
KW  - atmospheric aerosols
KW  - characteristics
KW  - absorption
KW  - black carbon
KW  - brown
KW  - carbon
KW  - dust
KW  - Himalayas
KW  - IGP
KW  - South Asia
Y1  - 2020
U6  - https://doi.org/10.1016/j.envint.2020.105814
SN  - 0160-4120
SN  - 1873-6750
VL  - 142
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Kaneza, Elisabeth
T1  - Black Lives Matter
BT  - warum Rasse nicht aus dem Grundgesetz gestrichen werden darf
JF  - Recht und Politik
N2  - In den USA und auch in Deutschland fordern Schwarze Menschen ihr verfassungsmäßiges Recht ein, nicht durch den Staat diskriminiert, verfolgt und ermordet zu werden. Sie wollen, dass Schwarze Leben in weiß dominierten Gesellschaften zählen. In der öffentlichen Diskussion jedoch scheint daran gezweifelt zu werden, dass Rasse als Rechtsbegriff und Marker von Zugehörigkeit von Bedeutung ist – was sich auch in den Forderungen widerspiegelt, den Begriff aus dem Grundgesetz zu streichen.
Y1  - 2020
U6  - https://doi.org/10.3790/rup.56.4.536
SN  - 0344-7871
SN  - 2366-6757
VL  - 56
IS  - 4
SP  - 536
EP  - 541
PB  - Duncker & Humblot
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Richardt, Kiraten
A1  - Prüß, Holger
T1  - Bonner Stotterherapie
BT  - Umsetzung und Evaluation eines Kombinationsansatzes
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469491
SN  - 978-3-86956-479-1
SN  - 1866-9085
SN  - 1866-9433
IS  - 12
SP  - 61
EP  - 78
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Michałowski, Jarosław M.
A1  - Wiwatowska, Ewa
A1  - Weymar, Mathias
T1  - Brain potentials reveal reduced attention and error-processing during a monetary Go/No-Go task in procrastination
JF  - Scientific reports
N2  - Procrastination is a self-regulatory problem of voluntarily and destructively delaying intended and necessary or personally important tasks. Previous studies showed that procrastination is associated with executive dysfunctions that seem to be particularly strong in punishing contexts. In the present event-related potential (ERP) study a monetary version of the parametric Go/No-Go task was performed by high and low academic procrastinators to verify the influence of motivational context (reward vs. punishment expectation) and task difficulty (easy vs. hard) on procrastination-related executive dysfunctions. The results revealed increased post-error slowing along with reduced P300 and error-related negativity (ERN) amplitudes in high (vs. low) procrastination participants-effects that indicate impaired attention and error-related processing in this group. This pattern of results did not differ as a function of task difficulty and motivation condition. However, when the task got more difficult executive attention deficits became even more apparent at the behavioral level in high procrastinators, as indexed by increased reaction time variability. The findings substantiate prior preliminary evidence that procrastinators show difficulties in certain aspects of executive functioning (in attention and error processing) during execution of task-relevant behavior, which may be more apparent in highly demanding situations.
KW  - Attention
KW  - Cognitive control
KW  - Motivation
KW  - Neurophysiology
KW  - Neuroscience
KW  - Psychology
KW  - Reward
Y1  - 2020
U6  - https://doi.org/10.1038/s41598-020-75311-2
SN  - 2045-2322
VL  - 10
IS  - 1
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Tschorn, Mira
A1  - Kuhlmann, Stella Linnea
A1  - Rieckmann, Nina
A1  - Beer, Katja
A1  - Grosse, Laura
A1  - Arolt, Volker
A1  - Waltenberger, Johannes
A1  - Haverkamp, Wilhelm
A1  - Müller-Nordhorn, Jacqueline
A1  - Hellweg, Rainer
A1  - Ströhle, Andreas
T1  - Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease
JF  - Acta Neuropsychiatrica
N2  - Objective: 
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). 

Methods: 
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. 

Results: 
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. 

Conclusion: 
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
KW  - depression
KW  - BDNF
KW  - coronary heart disease
KW  - heart failure
KW  - somatic comorbidity
KW  - acute coronary syndrome
Y1  - 2020
U6  - https://doi.org/10.1017/neu.2020.31
SN  - 1601-5215
SN  - 0924-2708
VL  - 33
IS  - 1
SP  - 22
EP  - 30
PB  - Cambridge Univ. Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Kaak, Heinrich
T1  - Brandenburgische Städte und Dreißigjähriger Krieg
BT  - Zerstörung und erster Wiederaufbau anhand der Beispiele Prenzlau und Neuruppin
JF  - Halb Europa in Brandenburg : der Dreißigjährige Krieg und seine Folgen
Y1  - 2020
SN  - 978-3-86732-323-9
SP  - 150
EP  - 171
PB  - Lukas
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Isailović, Dušan
A1  - Stojanovic, Vladeta
A1  - Trapp, Matthias
A1  - Richter, Rico
A1  - Hajdin, Rade
A1  - Döllner, Jürgen Roland Friedrich
T1  - Bridge damage
BT  - detection, IFC-based semantic enrichment and visualization
JF  - Automation in construction : an international research journal
N2  - Building Information Modeling (BIM) representations of bridges enriched by inspection data will add tremendous value to future Bridge Management Systems (BMSs). This paper presents an approach for point cloud-based detection of spalling damage, as well as integrating damage components into a BIM via semantic enrichment of an as-built Industry Foundation Classes (IFC) model. An approach for generating the as-built BIM, geometric reconstruction of detected damage point clusters and semantic-enrichment of the corresponding IFC model is presented. Multiview-classification is used and evaluated for the detection of spalling damage features. The semantic enrichment of as-built IFC models is based on injecting classified and reconstructed damage clusters back into the as-built IFC, thus generating an accurate as-is IFC model compliant to the BMS inspection requirements.
KW  - damage detection
KW  - building information modeling
KW  - 3D point clouds
KW  - multiview classification
KW  - bridge management systems
Y1  - 2020
U6  - https://doi.org/10.1016/j.autcon.2020.103088
SN  - 0926-5805
SN  - 1872-7891
VL  - 112
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Meijer, Saskia
T1  - Brothers: A Tale of Two Sons
JF  - „Wir alle treffen Entscheidungen im Leben, aber letztendlich treffen unsere Entscheidungen uns.“ : didaktische Potenziale digitaler Spielwelten
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485664
SN  - 978-3-86956-489-0
SP  - 107
EP  - 124
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Emanuel, Marc D.
A1  - Cherstvy, Andrey G.
A1  - Metzler, Ralf
A1  - Gompper, Gerhard
T1  - Buckling transitions and soft-phase invasion of two-component icosahedral shells
JF  - Physical review / publ. by The American Physical Society. E, Statistical, nonlinear, and soft matter physics
N2  - What is the optimal distribution of two types of crystalline phases on the surface of icosahedral shells, such as of many viral capsids? We here investigate the distribution of a thin layer of soft material on a crystalline convex icosahedral shell. We demonstrate how the shapes of spherical viruses can be understood from the perspective of elasticity theory of thin two-component shells. We develop a theory of shape transformations of an icosahedral shell upon addition of a softer, but still crystalline, material onto its surface. We show how the soft component "invades" the regions with the highest elastic energy and stress imposed by the 12 topological defects on the surface. We explore the phase diagram as a function of the surface fraction of the soft material, the shell size, and the incommensurability of the elastic moduli of the rigid and soft phases. We find that, as expected, progressive filling of the rigid shell by the soft phase starts from the most deformed regions of the icosahedron. With a progressively increasing soft-phase coverage, the spherical segments of domes are filled first (12 vertices of the shell), then the cylindrical segments connecting the domes (30 edges) are invaded, and, ultimately, the 20 flat faces of the icosahedral shell tend to be occupied by the soft material. We present a detailed theoretical investigation of the first two stages of this invasion process and develop a model of morphological changes of the cone structure that permits noncircular cross sections. In conclusion, we discuss the biological relevance of some structures predicted from our calculations, in particular for the shape of viral capsids.
Y1  - 2020
U6  - https://doi.org/10.1103/PhysRevE.102.062104
SN  - 2470-0045
SN  - 2470-0053
SN  - 2470-0061
SN  - 1538-4519
VL  - 102
IS  - 6
PB  - Woodbury
CY  - New York
ER  - 
TY  - JOUR
A1  - Feichtinger, Barbara
ED  - Ambühl, Annemarie
T1  - Bukolisches Idyll in Bethlehem
BT  - zur kulturellen Hybridität von Hieronymus Epistula 46
JF  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Transformative Translations in Jewish History and Culture
N2  - Epistula 46 is an invitation, written under the name of Paula and Eustochium, for Marcella to go to Bethlehem, by all means with the aim to stimulate positive interest in the Holy Land for a wider public and to inspire the urge to travel and sojourn. The narrative defines pilgrimage not only through biblical references but also familiarizes it through references to ancient pagan practices and pagan literature and makes it compatible with the lifestyle of Rome’s urban elites. While biblical references predominantly propagate Palestine’s spiritual appeal as a site of centuries-long salvation events, references to the classics – often combined with the expression or the stimulation of emotions – put the region’s social and intellectual appeal to the fore. The use of pagan literature, in which the traditions of educational travel of a cosmopolitan elite, the social utopia of aristocratic recessus, and not least the pleasure of otium aestheticised through literature are prefigurated, shapes Palestine in particular fashion as a place of longing. Especially the appeal of Bethlehem thus only forms through the combination of spiritual-intellectual visio and emotionally attractive social utopia, through conjunction of spelunca Christi and bucolic idyll.
KW  - Jerome
KW  - pilgrimage
KW  - intertextuality
KW  - cultural hybridity
KW  - Bethlehem
Y1  - 2020
U6  - https://doi.org/10.34679/thersites.vol11.168
SN  - 2364-7612
VL  - 2020
IS  - 11
SP  - 218
EP  - 246
ER  - 
TY  - JOUR
A1  - Grotheer, Hendrik
A1  - Meyer, Vera
A1  - Riedel, Theran
A1  - Pfalz, Gregor
A1  - Mathieu, Lucie
A1  - Hefter, Jens H.
A1  - Gentz, Torben
A1  - Lantuit, Hugues
A1  - Mollennauer, Gesine
A1  - Fritz, Michael
T1  - Burial and origin of permafrost-derived carbon in the nearshore zone of the southern Canadian Beaufort Sea
JF  - Geophysical research letters
N2  - Detailed organic geochemical and carbon isotopic (delta C-13 and Delta C-14) analyses are performed on permafrost deposits affected by coastal erosion (Herschel Island, Canadian Beaufort Sea) and adjacent marine sediments (Herschel Basin) to understand the fate of organic carbon in Arctic nearshore environments. We use an end-member model based on the carbon isotopic composition of bulk organic matter to identify sources of organic carbon. Monte Carlo simulations are applied to quantify the contribution of coastal permafrost erosion to the sedimentary carbon budget. The models suggest that similar to 40% of all carbon released by local coastal permafrost erosion is efficiently trapped and sequestered in the nearshore zone. This highlights the importance of sedimentary traps in environments such as basins, lagoons, troughs, and canyons for the carbon sequestration in previously poorly investigated, nearshore areas. 

Plain Language Summary Increasing air and sea surface temperatures at high latitudes leads to accelerated thaw, destabilization, and erosion of perennially frozen soils (i.e., permafrost), which are often rich in organic carbon. Coastal erosion leads to an increased mobilization of organic carbon into the Arctic Ocean, which there can be converted into greenhouse gases and may therefore contribute to further warming. Carbon decomposition can be limited if organic matter is efficiently deposited on the seafloor, buried in marine sediments, and thus removed from the short-term carbon cycle. Basins, canyons, and troughs near the coastline can serve as sediment traps and potentially accommodate large quantities of organic carbon along the Arctic coast. Here we use biomarkers (source-specific molecules), stable carbon isotopes, and radiocarbon to identify the sources of organic carbon in the nearshore zone of the southern Canadian Beaufort Sea near Herschel Island. We quantify the contribution of coastal permafrost erosion to the sedimentary carbon budget of the area and estimate that more than a third of all carbon released by local permafrost erosion is efficiently trapped in marine sediments. This highlights the importance of regional sediment traps for carbon sequestration.
Y1  - 2020
U6  - https://doi.org/10.1029/2019GL085897
SN  - 0094-8276
SN  - 1944-8007
VL  - 47
IS  - 3
PB  - Wiley
CY  - Hoboken, NJ
ER  - 
TY  - JOUR
A1  - Staniszewska, Lucyna
T1  - Bürgerliche Beschlussinitiative
JF  - KWI Schriften
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485338
SN  - 978-3-86956-486-9
SN  - 1867-951X
SN  - 1867-9528
IS  - 12
SP  - 77
EP  - 87
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Neumann, Helmuth Emanuel
T1  - Call of Duty: WWII
JF  - „Wir alle treffen Entscheidungen im Leben, aber letztendlich treffen unsere Entscheidungen uns.“ : didaktische Potenziale digitaler Spielwelten
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-485675
SN  - 978-3-86956-489-0
SP  - 125
EP  - 142
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Ay-Bryson, Destina Sevde
A1  - Weck, Florian
A1  - Heinze, Peter Eric
A1  - Lang, Thomas
A1  - Kühne, Franziska
T1  - Can psychotherapy trainees distinguish standardized patients from real patients?
T1  - Können Psychotherapeut*innen in Ausbildung standardisierte Patient*innen von realen Patient*innen unterscheiden?
BT  - a pilot study
BT  - Ergebnisse einer Pilotstudie
JF  - Zeitschrift für Klinische Psychologie und Psychotherapie
N2  - Background:
Under the new psychotherapy law in Germany, standardized patients (SPs) are to become a standard component inpsychotherapy training, even though little is known about their authenticity.Objective:The present pilot study explored whether, followingan exhaustive two-day SP training, psychotherapy trainees can distinguish SPs from real patients.

Methods:
Twenty-eight psychotherapytrainees (M= 28.54 years of age,SD= 3.19) participated as blind raters. They evaluated six video-recorded therapy segments of trained SPsand real patients using the Authenticity of Patient Demonstrations Scale.

Results:
The authenticity scores of real patients and SPs did notdiffer (p= .43). The descriptive results indicated that the highest score of authenticity was given to an SP. Further, the real patients did notdiffer significantly from the SPs concerning perceived impairment (p= .33) and the likelihood of being a real patient (p= .52).

Conclusions:
The current results suggest that psychotherapy trainees were unable to distinguish the SPs from real patients. We therefore stronglyrecommend incorporating training SPs before application. Limitations and future research directions are discussed.
N2  - Theoretischer Hintergrund:
Mit dem neu eingeführten Direktstudium für zukünftige Psychotherapeut_innen (PiA) wirdder Einsatz von standardisierten Patient_innen (SP) in der Lehre zunehmen, obwohl die Authentizität der Rollendarstellungen durch SPempirisch bislang kaum untersucht wurde. Ziel der vorliegenden Studie war es daher zu untersuchen, ob SP trainiert werden können, dassPsychotherapeut_innen in Ausbildung (PiA) SP von realen Patient_innen nicht unterscheiden können.

Methode:
Insgesamt nahmen 28 PiA(M= 28.54 Jahre,SD= 3.19) als verblindete Rater teil. Sie haben sechs Therapiesitzungen von trainierten SP und realen Patient_innen mitder Skala Authentizität von Patientendarstellungen bewertet.

Ergebnisse:
Die Authentizitätswerte von SP unterschieden sich nicht signifi-kant von realen Patient_innen (p= .43). Deskriptive Ergebnisse legen nahe, dass ein SP im Schnitt am authentischsten bewertet wurde.Darüber hinaus unterschieden sich SP und reale Patient_innen nicht hinsichtlich der wahrgenommenen Beeinträchtigung (p= .33) sowie derWahrscheinlichkeit, als reale/r Patient_in bewertet zu werden (p= .52).

Fazit:
Die vorliegenden Ergebnisse legen nahe, dass PiA SP vonrealen Patient_innen nicht unterscheiden konnten. Daher legen wir ein ausführliches Training der SP nahe, bevor sie für Studium und Lehreeingesetzt werden. Die Limitationen sowie zukünftige Forschungsideen werden diskutiert.
KW  - evidence-based training
KW  - learning
KW  - simulated patients
KW  - simulation-based
KW  - education
KW  - therapist competence
KW  - evidenzbasiertes Training
KW  - Lernen
KW  - Simulationspatient_innen
KW  - simulationsbasierte Lehre
KW  - therapeutische
KW  - Kompetenz
Y1  - 2020
U6  - https://doi.org/10.1026/1616-3443/a000594
SN  - 1616-3443
SN  - 2190-6297
VL  - 49
IS  - 3
SP  - 182
EP  - 190
PB  - Hogrefe
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Strauss, Volker
A1  - Wang, Huize
A1  - Delacroix, Simon
A1  - Ledendecker, Marc
A1  - Wessig, Pablo
T1  - Carbon nanodots revised
BT  - the thermal citric acid/urea reaction
JF  - Chemical science
N2  - Luminescent compounds obtained from the thermal reaction of citric acid and urea have been studied and utilized in different applications in the past few years. The identified reaction products range from carbon nitrides over graphitic carbon to distinct molecular fluorophores. On the other hand, the solid, non-fluorescent reaction product produced at higher temperatures has been found to be a valuable precursor for the CO2-laser-assisted carbonization reaction in carbon laser-patterning. This work addresses the question of structural identification of both, the fluorescent and non-fluorescent reaction products obtained in the thermal reaction of citric acid and urea. The reaction products produced during autoclave-microwave reactions in the melt were thoroughly investigated as a function of the reaction temperature and the reaction products were subsequently separated by a series of solvent extractions and column chromatography. The evolution of a green molecular fluorophore, namely HPPT, was confirmed and a full characterization study on its structure and photophysical properties was conducted. The additional blue fluorescence is attributed to oligomeric ureas, which was confirmed by complementary optical and structural characterization. These two components form strong hydrogen-bond networks which eventually react to form solid, semi-crystalline particles with a size of similar to 7 nm and an elemental composition of 46% C, 22% N, and 29% O. The structural features and properties of all three main components were investigated in a comprehensive characterization study.
Y1  - 2020
U6  - https://doi.org/10.1039/d0sc01605e
SN  - 2041-6520
SN  - 2041-6539
VL  - 11
IS  - 31
SP  - 8256
EP  - 8266
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Stiegler, Jonas
A1  - von Hoermann, Christian
A1  - Müller, Jörg
A1  - Benbow, Mark Eric
A1  - Heurich, Marco
T1  - Carcass provisioning for scavenger conservation in a temperate forest ecosystem
JF  - Ecosphere
N2  - Carrion plays an essential role in shaping the structure and functioning of ecosystems and has far‐reaching implications for biodiversity conservation. The change in availability and type of carcasses throughout ecosystems can involve negative effects for scavenging communities. To address this issue, there have been recent conservation management measures of carrion provision in natural systems. However, the optimal conditions under which exposing carcasses to optimize conservation outcomes are still limited. Here, we used camera traps throughout elevational and vegetational gradients to monitor the consumption of 48 deer carcasses over a study period of six years by evaluating 270,279 photographs resulting out of 15,373 trap nights. We detected 17 species visiting carcass deployments, including five endangered species. Our results show that large carcasses, the winter season, and a heterogeneous surrounding habitat enhanced the frequency of carcass visits and the species richness of scavenger assemblages. Contrary to our expectations, carcass species, condition (fresh/frozen), and provision schedule (continuous vs single exposure) did not influence scavenging frequency or diversity. The carcass visitation frequency increased with carcass mass and lower temperatures. The effect of large carcasses was especially pronounced for mesopredators and the Eurasian lynx (Lynx lynx ). Lynx were not too influenced in its carrion acquisition by the season, but exclusively preferred remote habitats containing higher forest cover. Birds of prey, mesopredators, and top predators were also positively influenced by the visiting rate of ravens (Corvus corax ), whereas no biotic or abiotic preferences were found for wild boars (Sus scrofa ). This study provides evidence that any ungulate species of carrion, either in a fresh or in previously frozen condition, attracts a high diversity of scavengers especially during winter, thereby supporting earlier work that carcass provisions may support scavenger communities and endangered species.
KW  - anthropogenic food subsidies
KW  - carrion ecology
KW  - diversity
KW  - nature conservation
KW  - necrobiome
KW  - vertebrate scavenger
KW  - wildlife management
Y1  - 2020
U6  - https://doi.org/10.1002/ecs2.3063
SN  - 2150-8925
VL  - 11
IS  - 4
PB  - ESA
CY  - Ithaca, NY
ER  - 
TY  - JOUR
A1  - Brecht, Pia
A1  - Beckendorf, Claudia
A1  - Mayer, Frank
T1  - Cardiac remodeling in child and adolescent athletes in association with sport discipline and sex
JF  - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine
N2  - Continuous high training loads are associated with structural cardiac adaptations and development of an athletic heart in adult athletes, especially in sport disciplines with high dynamic training components. In child and adolescent athletes these effects are increasingly reported. However, study populations are still very small.
Y1  - 2020
U6  - https://doi.org/10.1249/01.mss.0000679076.53908.d0
SN  - 0195-9131
SN  - 1530-0315
VL  - 52
IS  - 17
SP  - 472
EP  - 473
PB  - Lippincott Williams & Wilkins
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Häseli, Steffen
A1  - Deubel, Stefanie
A1  - Jung, Tobias
A1  - Grune, Tilman
A1  - Ott, Christiane
T1  - Cardiomyocyte contractility and autophagy in a premature senescence model of cardiac aging
JF  - Oxidative medicine and cellular longevity
N2  - Globally, cardiovascular diseases are the leading cause of death in the aging population. While the clinical pathology of the aging heart is thoroughly characterized, underlying molecular mechanisms are still insufficiently clarified. The aim of the present study was to establish an in vitro model system of cardiomyocyte premature senescence, culturing heart muscle cells derived from neonatal C57Bl/6J mice for 21 days. Premature senescence of neonatal cardiac myocytes was induced by prolonged culture time in an oxygen-rich postnatal environment. Age-related changes in cellular function were determined by senescence-associated beta-galactosidase activity, increasing presence of cell cycle regulators, such as p16, p53, and p21, accumulation of protein aggregates, and restricted proteolysis in terms of decreasing (macro-)autophagy. Furthermore, the culture system was functionally characterized for alterations in cell morphology and contractility. An increase in cellular size associated with induced expression of atrial natriuretic peptides demonstrated a stress-induced hypertrophic phenotype in neonatal cardiomyocytes. Using the recently developed analytical software tool Myocyter, we were able to show a spatiotemporal constraint in spontaneous contraction behavior during cultivation. Within the present study, the 21-day culture of neonatal cardiomyocytes was defined as a functional model system of premature cardiac senescence to study age-related changes in cardiomyocyte contractility and autophagy.
Y1  - 2020
U6  - https://doi.org/10.1155/2020/8141307
SN  - 1942-0994
VL  - 2020
IS  - Special Issue
PB  - Landes Bioscience
CY  - Austin, Tex.
ER  - 
TY  - JOUR
A1  - Caliendo, Marco
A1  - Künn, Steffen
A1  - Weissenberger, Martin
T1  - Catching up or lagging behind?
BT  - the long-term business and innovation potential of subsidized start-ups out of unemployment
JF  - Research policy : policy, management and economic studies of science, technology and innovation
N2  - From an active labor market policy perspective, start-up subsidies for unemployed individuals are very effective in improving long-term labor market outcomes for participants. From a business perspective, however, the assessment of these public programs is less clear since they might attract individuals with low entrepreneurial abilities and produce businesses with low survival rates and little contribution to job creation, economic growth, and innovation. In this paper, we use a rich data set to compare participants of a German start-up subsidy program for unemployed individuals to a group of regular founders who started from non-unemployment and did not receive the subsidy. The data allows us to analyze their business performance up until 40 months after business formation. We find that formerly subsidized founders lag behind not only in survival and job creation, but especially also in innovation activities. The gaps in these business outcomes are relatively constant or even widening over time. Hence, we do not see any indication of catching up in the longer run. While the gap in survival can be entirely explained by initial differences in observable start-up characteristics, the gap in business development remains and seems to be the result of restricted access to capital as well as differential business strategies and dynamics. Considering these conflicting results for the assessment of the subsidy program from an ALMP and business perspective, policy makers need to carefully weigh the costs and benefits of such a strategy to find the right policy mix.
KW  - entrepreneurship
KW  - start-up subsidies
KW  - business growth
KW  - innovation
KW  - job
KW  - creation
Y1  - 2020
U6  - https://doi.org/10.1016/j.respol.2020.104053
SN  - 0048-7333
SN  - 1873-7625
VL  - 49
IS  - 10
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Wei, Xiaoyan
A1  - Franke, Julia
A1  - Ost, Mario
A1  - Wardelmann, Kristina
A1  - Börno, Stefan
A1  - Timmermann, Bernd
A1  - Meierhofer, David
A1  - Kleinridders, Andre
A1  - Klaus, Susanne
A1  - Stricker, Sigmar
T1  - Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis
JF  - Journal of cachexia, sarcopenia and muscle
N2  - Background Neurofibromatosis type 1 (NF1) is a multi-organ disease caused by mutations in neurofibromin 1 (NF1). Amongst other features, NF1 patients frequently show reduced muscle mass and strength, impairing patients' mobility and increasing the risk of fall. The role of Nf1 in muscle and the cause for the NF1-associated myopathy are mostly unknown. Methods To dissect the function ofNf1in muscle, we created muscle-specific knockout mouse models for NF1, inactivatingNf1in the prenatal myogenic lineage either under the Lbx1 promoter or under the Myf5 promoter. Mice were analysed during prenatal and postnatal myogenesis and muscle growth. Results Nf1(Lbx1)and Nf1(Myf5)animals showed only mild defects in prenatal myogenesis. Nf1(Lbx1)animals were perinatally lethal, while Nf1(Myf5)animals survived only up to approximately 25 weeks. A comprehensive phenotypic characterization of Nf1(Myf5)animals showed decreased postnatal growth, reduced muscle size, and fast fibre atrophy. Proteome and transcriptome analyses of muscle tissue indicated decreased protein synthesis and increased proteasomal degradation, and decreased glycolytic and increased oxidative activity in muscle tissue. High-resolution respirometry confirmed enhanced oxidative metabolism in Nf1(Myf5)muscles, which was concomitant to a fibre type shift from type 2B to type 2A and type 1. Moreover, Nf1(Myf5)muscles showed hallmarks of decreased activation of mTORC1 and increased expression of atrogenes. Remarkably, loss of Nf1 promoted a robust activation of AMPK with a gene expression profile indicative of increased fatty acid catabolism. Additionally, we observed a strong induction of genes encoding catabolic cytokines in muscle Nf1(Myf5)animals, in line with a drastic reduction of white, but not brown adipose tissue. Conclusions Our results demonstrate a cell autonomous role for Nf1 in myogenic cells during postnatal muscle growth required for metabolic and proteostatic homeostasis. Furthermore, Nf1 deficiency in muscle drives cross-tissue communication and mobilization of lipid reserves.
KW  - neurofibromatosis
KW  - NF1
KW  - myopathy
KW  - muscle atrophy
KW  - muscle metabolism
KW  - muscle fibre type
KW  - AMPK
Y1  - 2020
U6  - https://doi.org/10.1002/jcsm.12632
SN  - 2190-5991
SN  - 2190-6009
VL  - 11
IS  - 6
SP  - 1758
EP  - 1778
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Dondapati, Srujan Kumar
A1  - Stech, Marlitt
A1  - Zemella, Anne
A1  - Kubick, Stefan
T1  - Cell-free protein synthesis
BT  - a promising option for future drug development
JF  - BioDrugs
N2  - Proteins are the main source of drug targets and some of them possess therapeutic potential themselves. Among them, membrane proteins constitute approximately 50% of the major drug targets. In the drug discovery pipeline, rapid methods for producing different classes of proteins in a simple manner with high quality are important for structural and functional analysis. Cell-free systems are emerging as an attractive alternative for the production of proteins due to their flexible nature without any cell membrane constraints. In a bioproduction context, open systems based on cell lysates derived from different sources, and with batch-to-batch consistency, have acted as a catalyst for cell-free synthesis of target proteins. Most importantly, proteins can be processed for downstream applications like purification and functional analysis without the necessity of transfection, selection, and expansion of clones. In the last 5 years, there has been an increased availability of new cell-free lysates derived from multiple organisms, and their use for the synthesis of a diverse range of proteins. Despite this progress, major challenges still exist in terms of scalability, cost effectiveness, protein folding, and functionality. In this review, we present an overview of different cell-free systems derived from diverse sources and their application in the production of a wide spectrum of proteins. Further, this article discusses some recent progress in cell-free systems derived from Chinese hamster ovary and Sf21 lysates containing endogenous translocationally active microsomes for the synthesis of membrane proteins. We particularly highlight the usage of internal ribosomal entry site sequences for more efficient protein production, and also the significance of site-specific incorporation of non-canonical amino acids for labeling applications and creation of antibody drug conjugates using cell-free systems. We also discuss strategies to overcome the major challenges involved in commercializing cell-free platforms from a laboratory level for future drug development.
Y1  - 2020
U6  - https://doi.org/10.1007/s40259-020-00417-y
SN  - 1173-8804
SN  - 1179-190X
VL  - 34
IS  - 3
SP  - 327
EP  - 348
PB  - Springer
CY  - Northcote
ER  - 
TY  - JOUR
A1  - Wüstenhagen, Doreen Anja
A1  - Lukas, Phil
A1  - Müller, Christian
A1  - Aubele, Simone A.
A1  - Hildebrandt, Jan-Peter
A1  - Kubick, Stefan
T1  - Cell-free synthesis of the hirudin variant 1 of the blood-sucking leech Hirudo medicinalis
JF  - Scientific reports
N2  - Synthesis and purification of peptide drugs for medical applications is a challenging task. The leech-derived factor hirudin is in clinical use as an alternative to heparin in anticoagulatory therapies. So far, recombinant hirudin is mainly produced in bacterial or yeast expression systems. We describe the successful development and application of an alternative protocol for the synthesis of active hirudin based on a cell-free protein synthesis approach. Three different cell lysates were compared, and the effects of two different signal peptide sequences on the synthesis of mature hirudin were determined. The combination of K562 cell lysates and the endogenous wild-type signal peptide sequence was most effective. Cell-free synthesized hirudin showed a considerably higher anti-thrombin activity compared to recombinant hirudin produced in bacterial cells.
Y1  - 2020
U6  - https://doi.org/10.1038/s41598-020-76715-w
SN  - 2045-2322
VL  - 10
IS  - 1
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - Ebert, Franziska
A1  - Ziemann, Vanessa
A1  - Wandt, Viktoria Klara Veronika
A1  - Witt, Barbara
A1  - Müller, Sandra Marie
A1  - Guttenberger, Nikolaus
A1  - Bankoglu, Ezgi Eyluel
A1  - Stopper, Helga
A1  - Raber, Georg
A1  - Francesconi, Kevin A.
A1  - Schwerdtle, Tanja
T1  - Cellular toxicological characterization of a thioxolated arsenic-containing hydrocarbon
JF  - Journal of trace elements in medicine and biology
N2  - Arsenolipids, especially arsenic-containing hydrocarbons (AsHC), are an emerging class of seafood originating contaminants. Here we toxicologically characterize a recently identified oxo-AsHC 332 metabolite, thioxo-AsHC 348 in cultured human liver (HepG2) cells. Compared to results of previous studies of the parent compound oxo-AsHC 332, thioxo-AsHC 348 substantially affected cell viability in the same concentration range but exerted about 10-fold lower cellular bioavailability. Similar to oxo-AsHC 332, thioxo-AsHC 348 did not substantially induce oxidative stress nor DNA damage. Moreover, in contrast to oxo-AsHC 332 mitochondria seem not to be a primary subcellular toxicity target for thioxo-AsHC 348. This study indicates that thioxo-AsHC 348 is at least as toxic as its parent compound oxo-AsHC 332 but very likely acts via a different mode of toxic action, which still needs to be identified.
Y1  - 2017
U6  - https://doi.org/10.1016/j.jtemb.2020.126563
VL  - 61
PB  - Elsevier
CY  - München
ER  - 
TY  - JOUR
A1  - Kaya, Kerem
A1  - Debsharma, Tapas
A1  - Schlaad, Helmut
A1  - Yagci, Yusuf
T1  - Cellulose-based polyacetals by direct and sensitized photocationic ring-opening polymerization of levoglucosenyl methyl ether
JF  - Polymer Chemistry
N2  - This study aims to explore the photoinitiated cationic ring-opening polymerization of levoglucosenyl methyl ether (LGME), a chemical obtained from the most abundant biomass - cellulose. Direct and sensitized photopolymerizations of LGME using photoinitiators acting at the near UV or visible range in conjunction with diphenyliodonium hexafluoroantimonate (DPI) yielded unsaturated polyacetals with varying molar masses and distributions.
Y1  - 2020
U6  - https://doi.org/10.1039/d0py01307b
SN  - 1759-9954
SN  - 1759-9962
VL  - 11
IS  - 43
SP  - 6884
EP  - 6889
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Esposito, Paolo
ED  - Ambühl, Annemarie
T1  - Cesare nella Troade: l’impossibile rinascita del passato
JF  - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien = Transformative Translations in Jewish History and Culture
N2  - Caesar’s visit to the ruins of ancient Troy in Lucan’s Bellum Civile book IX is an invented story which deals with important metaliterary themes such as poetic fama and the poetry’s eternalizing function. Lucan’s narrative also reveals the instrumental nature of Caesarean and Augustan propaganda: the Neronian poet highlights some contradictions of the Aeneid, showing the failure of the political project celebrated by Vergil.
KW  - Lucan
KW  - Caesar
KW  - historical memory
KW  - poetic glory
KW  - Aeneid
Y1  - 2020
U6  - https://doi.org/10.34679/thersites.vol11.164
SN  - 2364-7612
VL  - 2020
IS  - 11
SP  - 151
EP  - 175
ER  - 
TY  - JOUR
A1  - Schmidt, Lennart
A1  - Hesse, Falk
A1  - Attinger, Sabine
A1  - Kumar, Rohini
T1  - Challenges in applying machine learning models for hydrological inference
BT  - a case study for flooding events across Germany
JF  - Water resources research
N2  - Machine learning (ML) algorithms are being increasingly used in Earth and Environmental modeling studies owing to the ever-increasing availability of diverse data sets and computational resources as well as advancement in ML algorithms. Despite advances in their predictive accuracy, the usefulness of ML algorithms for inference remains elusive. In this study, we employ two popular ML algorithms, artificial neural networks and random forest, to analyze a large data set of flood events across Germany with the goals to analyze their predictive accuracy and their usability to provide insights to hydrologic system functioning. The results of the ML algorithms are contrasted against a parametric approach based on multiple linear regression. For analysis, we employ a model-agnostic framework named Permuted Feature Importance to derive the influence of models' predictors. This allows us to compare the results of different algorithms for the first time in the context of hydrology. Our main findings are that (1) the ML models achieve higher prediction accuracy than linear regression, (2) the results reflect basic hydrological principles, but (3) further inference is hindered by the heterogeneity of results across algorithms. Thus, we conclude that the problem of equifinality as known from classical hydrological modeling also exists for ML and severely hampers its potential for inference. To account for the observed problems, we propose that when employing ML for inference, this should be made by using multiple algorithms and multiple methods, of which the latter should be embedded in a cross-validation routine.
KW  - machine learning
KW  - inference
KW  - floods
Y1  - 2020
U6  - https://doi.org/10.1029/2019WR025924
SN  - 0043-1397
SN  - 1944-7973
VL  - 56
IS  - 5
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Schmidt, Lennart
A1  - Heße, Falk
A1  - Attinger, Sabine
A1  - Kumar, Rohini
T1  - Challenges in applying machine learning models for hydrological inference: a case study for flooding events across Germany
JF  - Water Resources Research
N2  - Machine learning (ML) algorithms are being increasingly used in Earth and Environmental modeling studies owing to the ever-increasing availability of diverse data sets and computational resources as well as advancement in ML algorithms. Despite advances in their predictive accuracy, the usefulness of ML algorithms for inference remains elusive. In this study, we employ two popular ML algorithms, artificial neural networks and random forest, to analyze a large data set of flood events across Germany with the goals to analyze their predictive accuracy and their usability to provide insights to hydrologic system functioning. The results of the ML algorithms are contrasted against a parametric approach based on multiple linear regression. For analysis, we employ a model-agnostic framework named Permuted Feature Importance to derive the influence of models' predictors. This allows us to compare the results of different algorithms for the first time in the context of hydrology. Our main findings are that (1) the ML models achieve higher prediction accuracy than linear regression, (2) the results reflect basic hydrological principles, but (3) further inference is hindered by the heterogeneity of results across algorithms. Thus, we conclude that the problem of equifinality as known from classical hydrological modeling also exists for ML and severely hampers its potential for inference. To account for the observed problems, we propose that when employing ML for inference, this should be made by using multiple algorithms and multiple methods, of which the latter should be embedded in a cross-validation routine.
KW  - machine learning
KW  - inference
KW  - floods
Y1  - 2019
VL  - 56
IS  - 5
PB  - John Wiley & Sons, Inc.
CY  - New Jersey
ER  -