TY - JOUR A1 - Eiserbeck, Anna A1 - Enge, Alexander A1 - Rabovsky, Milena A1 - Abdel Rahman, Rasha T1 - Electrophysiological chronometry of graded consciousness during the attentional blink JF - Cerebral cortex N2 - One of the ongoing debates about visual consciousness is whether it can be considered as an all-or-none or a graded phenomenon. While there is increasing evidence for the existence of graded states of conscious awareness based on paradigms such as visual masking, only little and mixed evidence is available for the attentional blink paradigm, specifically in regard to electrophysiological measures. Thereby, the all-or-none pattern reported in some attentional blink studies might have originated from specifics of the experimental design, suggesting the need to examine the generalizability of results. In the present event-related potential (ERP) study (N = 32), visual awareness of T2 face targets was assessed via subjective visibility ratings on a perceptual awareness scale in combination with ERPs time-locked to T2 onset (components P1, N1, N2, and P3). Furthermore, a classification task preceding visibility ratings allowed to track task performance. The behavioral results indicate a graded rather than an all-or-none pattern of visual awareness. Corresponding graded differences in the N1, N2, and P3 components were observed for the comparison of visibility levels. These findings suggest that conscious perception during the attentional blink can occur in a graded fashion. KW - attentional blink KW - consciousness KW - event-related potentials KW - neural KW - correlates of consciousness KW - perceptual awareness scale Y1 - 2021 U6 - https://doi.org/10.1093/cercor/bhab289 SN - 1047-3211 SN - 1460-2199 VL - 32 IS - 6 SP - 1244 EP - 1259 PB - Oxford University Press CY - New York, NY ER - TY - JOUR A1 - Heinsohn, Natascha Katharina A1 - Niedl, Robert Raimund A1 - Anielski, Alexander A1 - Lisdat, Fred A1 - Beta, Carsten T1 - Electrophoretic mu PAD for purification and analysis of DNA samples JF - Biosensors : open access journal N2 - In this work, the fabrication and characterization of a simple, inexpensive, and effective microfluidic paper analytic device (mu PAD) for monitoring DNA samples is reported. The glass microfiber-based chip has been fabricated by a new wax-based transfer-printing technique and an electrode printing process. It is capable of moving DNA effectively in a time-dependent fashion. The nucleic acid sample is not damaged by this process and is accumulated in front of the anode, but not directly on the electrode. Thus, further DNA processing is feasible. The system allows the DNA to be purified by separating it from other components in sample mixtures such as proteins. Furthermore, it is demonstrated that DNA can be moved through several layers of the glass fiber material. This proof of concept will provide the basis for the development of rapid test systems, e.g., for the detection of pathogens in water samples. KW - microfluidic paper analytic device (mu PAD) KW - patterning glass microfiber KW - fiber-electrophoresis chip KW - DNA KW - imprinted electrodes KW - cross layer chip KW - polymerase chain reaction (PCR) KW - purification Y1 - 2022 U6 - https://doi.org/10.3390/bios12020062 SN - 2079-6374 VL - 12 IS - 2 PB - MDPI CY - Basel ER - TY - JOUR A1 - Roy, Parna A1 - Mukherjee, Arpita A1 - Mondal, Pritha A1 - Bhattacharyya, Biswajit A1 - Narayan, Awadhesh A1 - Pandey, Anshu T1 - Electronic structure and spectroscopy of I-III-VI2 nanocrystals BT - a perspective JF - The journal of physical chemistry : C, Nanomaterials and interfaces N2 - I-III-VI2 semiconductor nanocrystals have been applied to a host of energy conversion devices with great success. Large scale implementation of device concepts based on these materials has, however, been somewhat stymied by the strong role of defects in determining the optoelectronic characteristics of these materials. Here we present a perspective view of the role of electronic structure and defects on the physical properties, particularly the spectroscopy, of this family of materials. Applications of these materials are further discussed in this context. Y1 - 2022 U6 - https://doi.org/10.1021/acs.jpcc.1c10922 SN - 1932-7447 SN - 1932-7455 VL - 126 IS - 17 SP - 7364 EP - 7373 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Mattern, Maximilian A1 - Reppert, Alexander von A1 - Zeuschner, Steffen Peer A1 - Pudell, Jan-Etienne A1 - Kühne, F. A1 - Diesing, Detlef A1 - Herzog, Marc A1 - Bargheer, Matias T1 - Electronic energy transport in nanoscale Au/Fe hetero-structures in the perspective of ultrafast lattice dynamics JF - Applied physics letters N2 - We study the ultrafast electronic transport of energy in a photoexcited nanoscale Au/Fe hetero-structure by modeling the spatiotemporal profile of energy densities that drives transient strain, which we quantify by femtosecond x-ray diffraction. This flow of energy is relevant for intrinsic demagnetization and ultrafast spin transport. We measured lattice strain for different Fe layer thicknesses ranging from few atomic layers to several nanometers and modeled the spatiotemporal flow of energy densities. The combination of a high electron-phonon coupling coefficient and a large Sommerfeld constant in Fe is found to yield electronic transfer of nearly all energy from Au to Fe within the first hundreds of femtoseconds. Y1 - 2022 U6 - https://doi.org/10.1063/5.0080378 SN - 0003-6951 SN - 1077-3118 VL - 120 IS - 9 PB - AIP Publishing CY - Melville ER - TY - JOUR A1 - Jafarnezhadgero, Amir Ali A1 - Fatollahi, Amir A1 - Granacher, Urs T1 - Eight weeks of exercising on sand has positive effects on biomechanics of walking and muscle activities in individuals with pronated feet BT - a randomized double-blinded controlled trial JF - Sports : open access journal N2 - This study aimed to investigate the effects of eight weeks of barefoot running exercise on sand versus control on measures of walking kinetics and muscle activities in individuals with diagnosed pronated feet. Sixty physically active male adults with pronated feet were randomly allocated into an intervention or a waiting control group. The intervention group conducted an 8-weeks progressive barefoot running exercise program on sand (e.g., short sprints) with three weekly sessions. Pre and post intervention, participants walked at a constant speed of 1.3 m/s +/- 5% on a 18 m walkway with a force plate embedded in the middle of the walkway. Results showed significant group-by-time interactions for peak impact vertical and lateral ground reaction forces. Training but not control resulted in significantly lower peak impact vertical and lateral ground reaction forces. Significant group-by-time interactions were observed for vastus lateralis activity during the loading phase. Training-induced increases were found for the vastus lateralis in the intervention but not in the control group. This study revealed that the applied exercise program is a suitable means to absorb ground reaction forces (e.g., lower impact vertical and lateral peaks) and increase activities of selected lower limb muscles (e.g., vastus lateralis) when walking on stable ground. KW - flat foot KW - free moment KW - gait KW - loading rate KW - training Y1 - 2022 U6 - https://doi.org/10.3390/sports10050070 SN - 2075-4663 VL - 10 IS - 5 PB - MDPI CY - Basel ER - TY - JOUR A1 - Bläsius, Thomas A1 - Friedrich, Tobias A1 - Lischeid, Julius A1 - Meeks, Kitty A1 - Schirneck, Friedrich Martin T1 - Efficiently enumerating hitting sets of hypergraphs arising in data profiling JF - Journal of computer and system sciences : JCSS N2 - The transversal hypergraph problem asks to enumerate the minimal hitting sets of a hypergraph. If the solutions have bounded size, Eiter and Gottlob [SICOMP'95] gave an algorithm running in output-polynomial time, but whose space requirement also scales with the output. We improve this to polynomial delay and space. Central to our approach is the extension problem, deciding for a set X of vertices whether it is contained in any minimal hitting set. We show that this is one of the first natural problems to be W[3]-complete. We give an algorithm for the extension problem running in time O(m(vertical bar X vertical bar+1) n) and prove a SETH-lower bound showing that this is close to optimal. We apply our enumeration method to the discovery problem of minimal unique column combinations from data profiling. Our empirical evaluation suggests that the algorithm outperforms its worst-case guarantees on hypergraphs stemming from real-world databases. KW - Data profiling KW - Enumeration algorithm KW - Minimal hitting set KW - Transversal hypergraph KW - Unique column combination KW - W[3]-Completeness Y1 - 2022 U6 - https://doi.org/10.1016/j.jcss.2021.10.002 SN - 0022-0000 SN - 1090-2724 VL - 124 SP - 192 EP - 213 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Bläsius, Thomas A1 - Freiberger, Cedric A1 - Friedrich, Tobias A1 - Katzmann, Maximilian A1 - Montenegro-Retana, Felix A1 - Thieffry, Marianne T1 - Efficient Shortest Paths in Scale-Free Networks with Underlying Hyperbolic Geometry JF - ACM Transactions on Algorithms N2 - A standard approach to accelerating shortest path algorithms on networks is the bidirectional search, which explores the graph from the start and the destination, simultaneously. In practice this strategy performs particularly well on scale-free real-world networks. Such networks typically have a heterogeneous degree distribution (e.g., a power-law distribution) and high clustering (i.e., vertices with a common neighbor are likely to be connected themselves). These two properties can be obtained by assuming an underlying hyperbolic geometry.
To explain the observed behavior of the bidirectional search, we analyze its running time on hyperbolic random graphs and prove that it is (O) over tilde (n(2-1/alpha) + n(1/(2 alpha)) + delta(max)) with high probability, where alpha is an element of (1/2, 1) controls the power-law exponent of the degree distribution, and dmax is the maximum degree. This bound is sublinear, improving the obvious worst-case linear bound. Although our analysis depends on the underlying geometry, the algorithm itself is oblivious to it. KW - Random graphs KW - hyperbolic geometry KW - scale-free networks KW - bidirectional shortest path Y1 - 2022 U6 - https://doi.org/10.1145/3516483 SN - 1549-6325 SN - 1549-6333 VL - 18 IS - 2 SP - 1 EP - 32 PB - Association for Computing Machinery CY - New York ER - TY - JOUR A1 - Schmidl, Sebastian A1 - Papenbrock, Thorsten T1 - Efficient distributed discovery of bidirectional order dependencies JF - The VLDB journal N2 - Bidirectional order dependencies (bODs) capture order relationships between lists of attributes in a relational table. They can express that, for example, sorting books by publication date in ascending order also sorts them by age in descending order. The knowledge about order relationships is useful for many data management tasks, such as query optimization, data cleaning, or consistency checking. Because the bODs of a specific dataset are usually not explicitly given, they need to be discovered. The discovery of all minimal bODs (in set-based canonical form) is a task with exponential complexity in the number of attributes, though, which is why existing bOD discovery algorithms cannot process datasets of practically relevant size in a reasonable time. In this paper, we propose the distributed bOD discovery algorithm DISTOD, whose execution time scales with the available hardware. DISTOD is a scalable, robust, and elastic bOD discovery approach that combines efficient pruning techniques for bOD candidates in set-based canonical form with a novel, reactive, and distributed search strategy. Our evaluation on various datasets shows that DISTOD outperforms both single-threaded and distributed state-of-the-art bOD discovery algorithms by up to orders of magnitude; it can, in particular, process much larger datasets. KW - Bidirectional order dependencies KW - Distributed computing KW - Actor KW - programming KW - Parallelization KW - Data profiling KW - Dependency discovery Y1 - 2021 U6 - https://doi.org/10.1007/s00778-021-00683-4 SN - 1066-8888 SN - 0949-877X VL - 31 IS - 1 SP - 49 EP - 74 PB - Springer CY - Berlin ; Heidelberg ; New York ER - TY - JOUR A1 - Grischek, Max A1 - Caprioglio, Pietro A1 - Zhang, Jiahuan A1 - Pena-Camargo, Francisco A1 - Sveinbjornsson, Kari A1 - Zu, Fengshuo A1 - Menzel, Dorothee A1 - Warby, Jonathan A1 - Li, Jinzhao A1 - Koch, Norbert A1 - Unger, Eva A1 - Korte, Lars A1 - Neher, Dieter A1 - Stolterfoht, Martin A1 - Albrecht, Steve T1 - Efficiency Potential and Voltage Loss of Inorganic CsPbI2Br Perovskite Solar Cells JF - Solar RRL N2 - Inorganic perovskite solar cells show excellent thermal stability, but the reported power conversion efficiencies are still lower than for organic-inorganic perovskites. This is mainly caused by lower open-circuit voltages (V(OC)s). Herein, the reasons for the low V-OC in inorganic CsPbI2Br perovskite solar cells are investigated. Intensity-dependent photoluminescence measurements for different layer stacks reveal that n-i-p and p-i-n CsPbI2Br solar cells exhibit a strong mismatch between quasi-Fermi level splitting (QFLS) and V-OC. Specifically, the CsPbI2Br p-i-n perovskite solar cell has a QFLS-e center dot V-OC mismatch of 179 meV, compared with 11 meV for a reference cell with an organic-inorganic perovskite of similar bandgap. On the other hand, this study shows that the CsPbI2Br films with a bandgap of 1.9 eV have a very low defect density, resulting in an efficiency potential of 20.3% with a MeO-2PACz hole-transporting layer and 20.8% on compact TiO2. Using ultraviolet photoelectron spectroscopy measurements, energy level misalignment is identified as a possible reason for the QFLS-e center dot V-OC mismatch and strategies for overcoming this V-OC limitation are discussed. This work highlights the need to control the interfacial energetics in inorganic perovskite solar cells, but also gives promise for high efficiencies once this issue is resolved. KW - CsPbI2Br KW - efficiency potentials KW - inorganic perovskites KW - photoluminescence KW - solar cells KW - voltage losses Y1 - 2022 U6 - https://doi.org/10.1002/solr.202200690 SN - 2367-198X VL - 6 IS - 11 PB - Wiley-VCH CY - Weinheim ER - TY - JOUR A1 - Delfan, Maryam A1 - Vahed, Alieh A1 - Bishop, David A1 - Juybari, Raheleh Amadeh A1 - Laher, Ismail A1 - Saeidi, Ayoub A1 - Granacher, Urs A1 - Zouhal, Hassane T1 - Effects of two workload-matched high-intensity interval training protocols on regulatory factors associated with mitochondrial biogenesis in the soleus muscle of diabetic rats JF - Frontiers in Physiology N2 - Aims: High intensity interval training (HIIT) improves mitochondrial characteristics. This study compared the impact of two workload-matched high intensity interval training (HIIT) protocols with different work:recovery ratios on regulatory factors related to mitochondrial biogenesis in the soleus muscle of diabetic rats. Materials and methods: Twenty-four Wistar rats were randomly divided into four equal-sized groups: non-diabetic control, diabetic control (DC), diabetic with long recovery exercise [4–5 × 2-min running at 80%–90% of the maximum speed reached with 2-min of recovery at 40% of the maximum speed reached (DHIIT1:1)], and diabetic with short recovery exercise (5–6 × 2-min running at 80%–90% of the maximum speed reached with 1-min of recovery at 30% of the maximum speed reached [DHIIT2:1]). Both HIIT protocols were completed five times/week for 4 weeks while maintaining equal running distances in each session. Results: Gene and protein expressions of PGC-1α, p53, and citrate synthase of the muscles increased significantly following DHIIT1:1 and DHIIT2:1 compared to DC (p ˂ 0.05). Most parameters, except for PGC-1α protein (p = 0.597), were significantly higher in DHIIT2:1 than in DHIIT1:1 (p ˂ 0.05). Both DHIIT groups showed significant increases in maximum speed with larger increases in DHIIT2:1 compared with DHIIT1:1. Conclusion: Our findings indicate that both HIIT protocols can potently up-regulate gene and protein expression of PGC-1α, p53, and CS. However, DHIIT2:1 has superior effects compared with DHIIT1:1 in improving mitochondrial adaptive responses in diabetic rats. KW - diabetes mellitus KW - muscle metabolism KW - time-efficient exercise KW - mitochondrial adaptation KW - exercise training Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.927969 SN - 1664-042X SP - 1 EP - 12 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Hannigan, Sara A1 - Nendel, Claas A1 - Krull, Marcos T1 - Effects of temperature on the movement and feeding behaviour of the large lupine beetle, Sitona gressorius JF - Journal of pest science N2 - Even though the effects of insect pests on global agricultural productivity are well recognised, little is known about movement and dispersal of many species, especially in the context of global warming. This work evaluates how temperature and light conditions affect different movement metrics and the feeding rate of the large lupine beetle, an agricultural pest responsible for widespread damage in leguminous crops. By using video recordings, the movement of 384 beetles was digitally analysed under six different temperatures and light conditions in the laboratory. Bayesian linear mixed-effect models were used to analyse the data. Furthermore, the effects of temperature on the daily diffusion coefficient of beetles were estimated by using hidden Markov models and random walk simulations. Results of this work show that temperature, light conditions, and beetles' weight were the main factors affecting the flight probability, displacement, time being active and the speed of beetles. Significant variations were also observed in all evaluated metrics. On average, beetles exposed to light conditions and higher temperatures had higher mean speed and flight probability. However, beetles tended to stay more active at higher temperatures and less active at intermediate temperatures, around 20 degrees C. Therefore, both the diffusion coefficient and displacement of beetles were lower at intermediate temperatures. These results show that the movement behaviour and feeding rates of beetles can present different relationships in the function of temperature. It also shows that using a single diffusion coefficient for insects in spatially explicit models may lead to over- or underestimation of pest spread. KW - Agricultural pests KW - Diffusion KW - Hidden Markov models KW - Movement ecology Y1 - 2022 U6 - https://doi.org/10.1007/s10340-022-01510-7 SN - 1612-4758 SN - 1612-4766 SP - 389 EP - 402 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Lenkeit, Jenny A1 - Hartmann, Anne A1 - Ehlert, Antje A1 - Knigge, Michel A1 - Spörer, Nadine T1 - Effects of special educational needs and socioeconomic status on academic achievement BT - Separate or confounded? JF - International Journal of Educational Research N2 - Germany is continuously expanding its inclusive education system. Research provides evidence that students with special educational needs (SEN) in inclusive school settings show lower academic achievement and come from lower socioeconomic backgrounds than their peers without SEN. Identifying to what extent the disadvantages originating from both characteristics are confounded in predicting academic achievement, has been neglected in the German educational context. Using data of 1711 primary and secondary school students from a longitudinal study in the state of Brandenburg, this study evaluates to what degree SEN (in the areas of learning and emotional-social difficulties) and socioeconomic background (SES) are confounded in predicting academic initial achievement in reading and mathematics as well as their development over time. Using multilevel modelling techniques that nest three measurement points into students and students into classes, results identify SES and SEN as relevant predictors of achievement status and growth in both subjects. Only few and small mediation effects of SES were found, indicating that both SES and SEN remain independent risk factors for achievement. Understanding the origins of student disadvantage can help teachers to make better informed choices for designing support measures and aid policymakers' reasoning for resource allocations. KW - Special educational needs KW - Socioeconomic background KW - Multiple disparities KW - Longitudinal KW - Hierarchical linear modelling Y1 - 2022 U6 - https://doi.org/10.1016/j.ijer.2022.101957 SN - 0883-0355 VL - 113 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Singh, Gaurav A1 - Kushwah, Gaurav Singh A1 - Singh, Tanvi A1 - Thapa, Rohit Kumar A1 - Granacher, Urs A1 - Ramirez-Campillo, Rodrigo T1 - Effects of sand-based plyometric-jump training in combination with endurance running on outdoor or treadmill surface on physical fitness in young adult males JF - Journal of sports science & medicine N2 - This study aimed at examining the effects of nine weeks of sand-based plyometric jump training (PJT) combined with endurance running on either outdoor or treadmill surface on measures of physical fitness. Male participants (age, 20.1 +/- 1.7 years) were randomly assigned to a sand-based PJT combined with endurance running on outdoor surface (OT, n = 25) or treadmill surface (TT, n = 25). The endurance miming intervention comprised a mixed training method, i.e., long slow distance, tempo, and interval running drills. A control group was additionally included in this study (CG, n = 25). Participants in CG followed their regular physical activity as OT and TT but did not receive any specific intervention. Individuals were assessed for their 50-m linear sprint time, standing long jump (SLJ) distance, cardiorespiratory fitness (i.e., Cooper test), forced vital capacity (FVC), calf girth, and resting heart rate (RHR). A three (groups: OT, TT, CG) by two (time: pre, post) ANOVA for repeated measures was used to analyze the exercise-specific effects. In case of significant group-by-time interactions, Bonferroni adjusted paired (within-group) and independent (between-group comparisons at post) t-tests were used for post-hoc analyses. Significant group-by-time interactions were found for all dependent variables (p < 0.001 - 0.002, eta(2)(p) = 0.16 - 0.78). Group-specific post-hoc tests showed improvements for all variables after OT (p < 0.001, Hedges'g effect size [g] = 0.05 - 1.94) and TT (p < 0.001, g = 0.04 - 2.73), but not in the CG (p = 0.058 - 1.000, g = 0.00 - 0.34). Compared to CG, OT showed larger SLJ (p = 0.001), cardiorespiratory fitness (p = 0.004), FVC (p = 0.008), and RHR (p < 0.001) improvements. TT showed larger improvements in SLJ (p = 0.036), cardiorespiratory fitness (p < 0.001), and RHR (p < 0.001) compared with CG. Compared to OT, TT showed larger improvements for SLJ (p = 0.018). In conclusion, sand-based PJT combined with either OT or TT similarly improved most measures of physical fitness, with greater SLJ improvement after TT. Coaches may use both concurrent exercise regimes based on preferences and logistical constrains (e.g., weather; access to treadmill equipment). KW - Muscle strength KW - musculoskeletal and neural physiological phenomena KW - movement KW - resistance training KW - high-intensity interval training KW - exercise Y1 - 2022 U6 - https://doi.org/10.52082/jssm.2022.277 SN - 1303-2968 VL - 21 IS - 2 SP - 277 EP - 286 PB - Department of Sports Medicine, Medical Faculty of Uludag University CY - Bursa ER - TY - JOUR A1 - Jafarnezhadgero, Amir Ali A1 - Amirzadeh, Nasrin A1 - Fatollahi, Amir A1 - Siahkouhian, Marefat A1 - de Souza Castelo Oliveira, Anderson A1 - Granacher, Urs T1 - Effects of running on sand vs. stable ground on kinetics and muscle activities in individuals with over-pronated feet JF - Frontiers in physiology / Frontiers Research Foundation N2 - Background: In terms of physiological and biomechanical characteristics, over-pronation of the feet has been associated with distinct muscle recruitment patterns and ground reaction forces during running. Objective: The aim of this study was to evaluate the effects of running on sand vs. stable ground on ground-reaction-forces (GRFs) and electromyographic (EMG) activity of lower limb muscles in individuals with over-pronated feet (OPF) compared with healthy controls. Methods: Thirty-three OPF individuals and 33 controls ran at preferred speed and in randomized-order over level-ground and sand. A force-plate was embedded in an 18-m runway to collect GRFs. Muscle activities were recorded using an EMG-system. Data were adjusted for surface-related differences in running speed. Results: Running on sand resulted in lower speed compared with stable ground running (p < 0.001; d = 0.83). Results demonstrated that running on sand produced higher tibialis anterior activity (p = 0.024; d = 0.28). Also, findings indicated larger loading rates (p = 0.004; d = 0.72) and greater vastus medialis (p < 0.001; d = 0.89) and rectus femoris (p = 0.001; d = 0.61) activities in OPF individuals. Controls but not OPF showed significantly lower gluteus-medius activity (p = 0.022; d = 0.63) when running on sand. Conclusion: Running on sand resulted in lower running speed and higher tibialis anterior activity during the loading phase. This may indicate alterations in neuromuscular demands in the distal part of the lower limbs when running on sand. In OPF individuals, higher loading rates together with greater quadriceps activity may constitute a proximal compensatory mechanism for distal surface instability. KW - flat feet KW - loading rate KW - lower limb mechanics KW - unstable walkway KW - muscle Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2021.822024 SN - 1664-042X VL - 12 SP - 1 EP - 10 PB - Frontiers Research Foundation CY - Lausanne, Schweiz ER - TY - JOUR A1 - Ramirez-Campillo, Rodrigo A1 - Pérez-Castilla, Alejandro A1 - Thapa, Rohit Kumar A1 - Afonso, José A1 - Clemente, Filipe Manuel Batista A1 - Colado, Juan C. A1 - Eduardo, Saéz de Villarreal A1 - Chaabene, Helmi T1 - Effects of Plyometric Jump Training on Measures of Physical Fitness and Sport-Specific Performance of Water Sports Athletes BT - A Systematic Review with Meta-analysis JF - Sports Medicine - Open N2 - Background A growing body of literature is available regarding the effects of plyometric jump training (PJT) on measures of physical fitness (PF) and sport-specific performance (SSP) in-water sports athletes (WSA, i.e. those competing in sports that are practiced on [e.g. rowing] or in [e.g. swimming; water polo] water). Indeed, incoherent findings have been observed across individual studies making it difficult to provide the scientific community and coaches with consistent evidence. As such, a comprehensive systematic literature search should be conducted to clarify the existent evidence, identify the major gaps in the literature, and offer recommendations for future studies. Aim To examine the effects of PJT compared with active/specific-active controls on the PF (one-repetition maximum back squat strength, squat jump height, countermovement jump height, horizontal jump distance, body mass, fat mass, thigh girth) and SSP (in-water vertical jump, in-water agility, time trial) outcomes in WSA, through a systematic review with meta-analysis of randomized and non-randomized controlled studies. Methods The electronic databases PubMed, Scopus, and Web of Science were searched up to January 2022. According to the PICOS approach, the eligibility criteria were: (population) healthy WSA; (intervention) PJT interventions involving unilateral and/or bilateral jumps, and a minimal duration of ≥ 3 weeks; (comparator) active (i.e. standard sports training) or specific-active (i.e. alternative training intervention) control group(s); (outcome) at least one measure of PF (e.g. jump height) and/or SSP (e.g. time trial) before and after training; and (study design) multi-groups randomized and non-randomized controlled trials. The Physiotherapy Evidence Database (PEDro) scale was used to assess the methodological quality of the included studies. The DerSimonian and Laird random-effects model was used to compute the meta-analyses, reporting effect sizes (ES, i.e. Hedges’ g) with 95% confidence intervals (95% CIs). Statistical significance was set at p ≤ 0.05. Certainty or confidence in the body of evidence for each outcome was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE), considering its five dimensions: risk of bias in studies, indirectness, inconsistency, imprecision, and risk of publication bias. Results A total of 11,028 studies were identified with 26 considered eligible for inclusion. The median PEDro score across the included studies was 5.5 (moderate-to-high methodological quality). The included studies involved a total of 618 WSA of both sexes (330 participants in the intervention groups [31 groups] and 288 participants in the control groups [26 groups]), aged between 10 and 26 years, and from different sports disciplines such as swimming, triathlon, rowing, artistic swimming, and water polo. The duration of the training programmes in the intervention and control groups ranged from 4 to 36 weeks. The results of the meta-analysis indicated no effects of PJT compared to control conditions (including specific-active controls) for in-water vertical jump or agility (ES =  − 0.15 to 0.03; p = 0.477 to 0.899), or for body mass, fat mass, and thigh girth (ES = 0.06 to 0.15; p = 0.452 to 0.841). In terms of measures of PF, moderate-to-large effects were noted in favour of the PJT groups compared to the control groups (including specific-active control groups) for one-repetition maximum back squat strength, horizontal jump distance, squat jump height, and countermovement jump height (ES = 0.67 to 1.47; p = 0.041 to < 0.001), in addition to a small effect noted in favour of the PJT for SSP time-trial speed (ES = 0.42; p = 0.005). Certainty of evidence across the included studies varied from very low-to-moderate. Conclusions PJT is more effective to improve measures of PF and SSP in WSA compared to control conditions involving traditional sport-specific training as well as alternative training interventions (e.g. resistance training). It is worth noting that the present findings are derived from 26 studies of moderate-to-high methodological quality, low-to-moderate impact of heterogeneity, and very low-to-moderate certainty of evidence based on GRADE. Trial registration The protocol for this systematic review with meta-analysis was published in the Open Science platform (OSF) on January 23, 2022, under the registration doi https://doi.org/10.17605/OSF.IO/NWHS3 (internet archive link: https://archive.org/details/osf-registrations-nwhs3-v1). KW - Plyometric exercise KW - Musculoskeletal and neural physiological phenomena KW - Human physical conditioning KW - Movement KW - Muscle strength KW - Resistance training Y1 - 2022 U6 - https://doi.org/10.1186/s40798-022-00502-2 SN - 2198-9761 VL - 8 SP - 1 EP - 27 PB - Springer CY - Berlin ER - TY - JOUR A1 - Gebel, Arnd A1 - Busch, Aglaja A1 - Stelzel, Christine A1 - Hortobágyi, Tibor A1 - Granacher, Urs T1 - Effects of Physical and Mental Fatigue on Postural Sway and Cortical Activity in Healthy Young Adults JF - Frontiers in Human Neuroscience N2 - Physical fatigue (PF) negatively affects postural control, resulting in impaired balance performance in young and older adults. Similar effects on postural control can be observed for mental fatigue (MF) mainly in older adults. Controversial results exist for young adults. There is a void in the literature on the effects of fatigue on balance and cortical activity. Therefore, this study aimed to examine the acute effects of PF and MF on postural sway and cortical activity. Fifteen healthy young adults aged 28 ± 3 years participated in this study. MF and PF protocols comprising of an all-out repeated sit-to-stand task and a computer-based attention network test, respectively, were applied in random order. Pre and post fatigue, cortical activity and postural sway (i.e., center of pressure displacements [CoPd], velocity [CoPv], and CoP variability [CV CoPd, CV CoPv]) were tested during a challenging bipedal balance board task. Absolute spectral power was calculated for theta (4–7.5 Hz), alpha-2 (10.5–12.5 Hz), beta-1 (13–18 Hz), and beta-2 (18.5–25 Hz) in frontal, central, and parietal regions of interest (ROI) and baseline-normalized. Inference statistics revealed a significant time-by-fatigue interaction for CoPd (p = 0.009, d = 0.39, Δ 9.2%) and CoPv (p = 0.009, d = 0.36, Δ 9.2%), and a significant main effect of time for CoP variability (CV CoPd: p = 0.001, d = 0.84; CV CoPv: p = 0.05, d = 0.62). Post hoc analyses showed a significant increase in CoPd (p = 0.002, d = 1.03) and CoPv (p = 0.003, d = 1.03) following PF but not MF. For cortical activity, a significant time-by-fatigue interaction was found for relative alpha-2 power in parietal (p < 0.001, d = 0.06) areas. Post hoc tests indicated larger alpha-2 power increases after PF (p < 0.001, d = 1.69, Δ 3.9%) compared to MF (p = 0.001, d = 1.03, Δ 2.5%). In addition, changes in parietal alpha-2 power and measures of postural sway did not correlate significantly, irrespective of the applied fatigue protocol. No significant changes were found for the other frequency bands, irrespective of the fatigue protocol and ROI under investigation. Thus, the applied PF protocol resulted in increased postural sway (CoPd and CoPv) and CoP variability accompanied by enhanced alpha-2 power in the parietal ROI while MF led to increased CoP variability and alpha-2 power in our sample of young adults. Potential underlying cortical mechanisms responsible for the greater increase in parietal alpha-2 power after PF were discussed but could not be clearly identified as cause. Therefore, further future research is needed to decipher alternative interpretations. KW - balance KW - cognitive/muscular fatigue KW - EEG KW - theta KW - alpha-2 Y1 - 2022 U6 - https://doi.org/10.3389/fnhum.2022.871930 SN - 1662-5161 VL - 16 SP - 1 EP - 14 PB - Frontiers Media S.A. CY - Lausanne, Schweiz ER - TY - JOUR A1 - Busch, Aglaja A1 - Trounson, Karl M. A1 - Browne, Peter A1 - Robertson, Sam T1 - Effects of lower limb light-weight wearable resistance on running biomechanics JF - Journal of biomechanics : affiliated with the American Society of Biomechanics, the European Society of Biomechanics, the International Society of Biomechanics, the Japanese Society for Clinical Biomechanics and Related Research and the Australian and New Zealand Society of Biomechanics N2 - Wearable resistance allows individualized loading for sport specific movements and can lead to specific strength adaptations benefiting the athlete. The objective was to determine biomechanical changes during running with lower limb light-weight wearable resistance. Fourteen participants (age: 28 +/- 4 years; height: 180 +/- 8 cm; body mass: 77 +/- 6 kg) wore shorts and calf sleeves of a compression suit allowing attachment of light loads. Participants completed four times two mins 20-m over-ground shuttle running bouts at 3.3 m*s(-1) alternated by three mins rest. The first running bout was unloaded and the other three bouts were under randomised loaded conditions (1%, 3% and 5% additional loading of the individual body mass). 3D motion cameras and force plates recorded kinematic and kinetic data at the midpoint of each 20-m shuttle. Friedman-test for repeated measures and linear mixed effect model analysis were used to determine differences between the loading conditions (alpha = 0.05). Increased peak vertical ground reaction force (2.7 N/kg to 2.74 N/kg), ground contact time (0.20 s to 0.21 s) and decreased step length (1.49 m to 1.45 m) were found with additional 5 % body mass loading compared to unloaded running (0.001 > p < 0.007). Marginally more knee flexion and hip extension and less plantarflexion was seen with higher loading. Differences in the assessed parameters were present between each loading condition but accompanied by subject variability. Further studies, also examining long term effects, should be conducted to further inform use of this training tool. KW - Kinematic KW - Kinetic KW - Weighted running KW - External loading KW - 3D motion KW - capture Y1 - 2022 U6 - https://doi.org/10.1016/j.jbiomech.2021.110903 SN - 0021-9290 SN - 1873-2380 VL - 130 PB - Elsevier Science CY - New York, NY [u.a.] ER - TY - JOUR A1 - Behrendt, Tom A1 - Bielitzki, Robert A1 - Behrens, Martin A1 - Herold, Fabian A1 - Schega, Lutz T1 - Effects of intermittent hypoxia-hyperoxia on performance- and health-related outcomes in humans BT - a systematic review JF - Sports medicine - open N2 - Background: Intermittent hypoxia applied at rest or in combination with exercise promotes multiple beneficial adaptations with regard to performance and health in humans. It was hypothesized that replacing normoxia by moderate hyperoxia can increase the adaptive response to the intermittent hypoxic stimulus. Objective: Our objective was to systematically review the current state of the literature on the effects of chronic intermittent hypoxia-hyperoxia (IHH) on performance- and health-related outcomes in humans. Methods: PubMed, Web of Science (TM), Scopus, and Cochrane Library databases were searched in accordance with PRISMA guidelines (January 2000 to September 2021) using the following inclusion criteria: (1) original research articles involving humans, (2) investigation of the chronic effect of IHH, (3) inclusion of a control group being not exposed to IHH, and (4) articles published in peer-reviewed journals written in English. Results: Of 1085 articles initially found, eight studies were included. IHH was solely performed at rest in different populations including geriatric patients (n = 1), older patients with cardiovascular (n = 3) and metabolic disease (n = 2) or cognitive impairment (n = 1), and young athletes with overtraining syndrome (n = 1). The included studies confirmed the beneficial effects of chronic exposure to IHH, showing improvements in exercise tolerance, peak oxygen uptake, and global cognitive functions, as well as lowered blood glucose levels. A trend was discernible that chronic exposure to IHH can trigger a reduction in systolic and diastolic blood pressure. The evidence of whether IHH exerts beneficial effects on blood lipid levels and haematological parameters is currently inconclusive. A meta-analysis was not possible because the reviewed studies had a considerable heterogeneity concerning the investigated populations and outcome parameters. Conclusion: Based on the published literature, it can be suggested that chronic exposure to IHH might be a promising non-pharmacological intervention strategy for improving peak oxygen consumption, exercise tolerance, and cognitive performance as well as reducing blood glucose levels, and systolic and diastolic blood pressure in older patients with cardiovascular and metabolic diseases or cognitive impairment. However, further randomized controlled trials with adequate sample sizes are needed to confirm and extend the evidence. This systematic review was registered on the international prospective register of systematic reviews (PROSPERO-ID: CRD42021281248) (https://www.crd.york.ac.uk/prospero/). KW - hypoxic conditioning KW - cognitive impairment KW - metabolic disease KW - cardiovascular disease KW - geriatrics KW - therapy Y1 - 2022 U6 - https://doi.org/10.1186/s40798-022-00450-x SN - 2199-1170 SN - 2198-9761 VL - 8 IS - 1 PB - Springer CY - Berlin [u.a.] ER - TY - JOUR A1 - Prieske, Olaf A1 - Chaabene, Helmi A1 - Kullmann, Niclas A1 - Granacher, Urs T1 - Effects of Individualized Versus Traditional Power Training on Strength, Power, Jump Performances, and Body Composition in Young Male Nordic Athletes JF - International journal of sports physiology and performance N2 - Purpose: This study aimed to examine the effects of individualized-load power training (IPT) versus traditional moderate-load power training (TPT) on strength, power, jump performance, and body composition in elite young Nordic athletes. Methods: In a randomized crossover design, 10 young male athletes (ski jumpers, Nordic combined athletes) age 17.5 (0.6) years (biological maturity status: +3.5 y postpeak height velocity) who competed on a national or international level performed 5 weeks of IPT (4 x 5 repetitions at 49%-72% 1-repetiton maximum [RM]) and TPT (5 x 5 repetitions at 50%-60% 1-RM) in addition to their regular training. Testing before, between, and after both training blocks comprised the assessment of muscle strength (loaded back squat 3-RM), power (maximal loaded back squat power), jump performance (eg, drop-jump height, reactive strength index), and body composition (eg, skeletal muscle mass). Results: Significant, large-size main effects for time were found for muscle strength (P < .01; g = 2.7), reactive strength index (P = .03; g= 1.6), and drop jump height (P = .02; g= 1.9) irrespective of the training condition (IPT, TPT). No significant time-by-condition interactions were observed. For measures of body composition, no significant main effects of condition and time or time-by-condition interactions were found. Conclusions: Our findings demonstrate that short-term IPT and TPT at moderate loads in addition to regular training were equally effective in improving measures of muscle strength (loaded back squat 3-RM) and vertical jump performance (reactive strength index, drop jump, and height) in young Nordic athletes. KW - ballistic training KW - optimal load KW - monitoring KW - progression KW - ski jumping Y1 - 2022 U6 - https://doi.org/10.1123/ijspp.2021-0074 SN - 1555-0265 SN - 1555-0273 VL - 17 IS - 4 SP - 541 EP - 548 PB - Human Kinetics Publ. CY - Champaign ER - TY - JOUR A1 - Hering, Robert A1 - Hauptfleisch, Morgan A1 - Kramer-Schadt, Stephanie A1 - Stiegler, Jonas A1 - Blaum, Niels T1 - Effects of fences and fence gaps on the movement behavior of three southern African antelope species JF - Frontiers in Conservation Science N2 - Globally, migratory ungulates are affected by fences. While field observational studies reveal the amount of animal–fence interactions across taxa, GPS tracking-based studies uncover fence effects on movement patterns and habitat selection. However, studies on the direct effects of fences and fence gaps on movement behavior, especially based on high-frequency tracking data, are scarce. We used GPS tracking on three common African antelopes (Tragelaphus strepsiceros, Antidorcas marsupialis, and T. oryx) with movement strategies ranging from range residency to nomadism in a semi-arid, Namibian savanna traversed by wildlife-proof fences that elephants have regularly breached. We classified major forms of ungulate–fence interaction types on a seasonal and a daily scale. Furthermore, we recorded the distances and times spent at fences regarding the total individual space use. Based on this, we analyzed the direct effects of fences and fence gaps on the animals’ movement behavior for the previously defined types of animal–fence interactions. Antelope-fence interactions peaked during the early hours of the day and during seasonal transitions when the limiting resource changed between water and forage. Major types of ungulate–fence interactions were quick, trace-like, or marked by halts. We found that the amount of time spent at fences was highest for nomadic eland. Migratory springbok adjusted their space use concerning fence gap positions. If the small home ranges of sedentary kudu included a fence, they frequently interacted with this fence. For springbok and eland, distance traveled along a fence declined with increasing utilization of a fence gap. All species reduced their speed in the proximity of a fence but often increased their speed when encountering the fence. Crossing a fence led to increased speeds for all species. We demonstrate that fence effects mainly occur during crucial foraging times (seasonal scale) and during times of directed movements (daily scale). Importantly, we provide evidence that fences directly alter antelope movement behaviors with negative implications for energy budgets and that persistent fence gaps can reduce the intensity of such alterations. Our findings help to guide future animal–fence studies and provide insights for wildlife fencing and fence gap planning. KW - fence ecology KW - veterinary cordon fence KW - ungulate KW - movement speed KW - fence interaction KW - GPS KW - Africa KW - wildlife conservation Y1 - 2022 U6 - https://doi.org/10.3389/fcosc.2022.959423 SN - 2673-611X VL - 3 SP - 1 EP - 19 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Yuan, Jun A1 - Zhang, Chujun A1 - Qiu, Beibei A1 - Liu, Wei A1 - So, Shu Kong A1 - Mainville, Mathieu A1 - Leclerc, Mario A1 - Shoaee, Safa A1 - Neher, Dieter A1 - Zou, Yingping T1 - Effects of energetic disorder in bulk heterojunction organic solar cells JF - Energy & environmental science N2 - Organic solar cells (OSCs) have progressed rapidly in recent years through the development of novel organic photoactive materials, especially non-fullerene acceptors (NFAs). Consequently, OSCs based on state-of-the-art NFAs have reached significant milestones, such as similar to 19% power conversion efficiencies (PCEs) and small energy losses (less than 0.5 eV). Despite these significant advances, understanding of the interplay between molecular structure and optoelectronic properties lags significantly behind. For example, despite the theoretical framework for describing the energetic disorder being well developed for the case of inorganic semiconductors, the question of the applicability of classical semiconductor theories in analyzing organic semiconductors is still under debate. A general observation in the inorganic field is that inorganic photovoltaic materials possessing a polycrystalline microstructure exhibit suppressed disorder properties and better charge carrier transport compared to their amorphous analogs. Accordingly, this principle extends to the organic semiconductor field as many organic photovoltaic materials are synthesized to pursue polycrystalline-like features. Yet, there appears to be sporadic examples that exhibit an opposite trend. However, full studies decoupling energetic disorder from aggregation effects have largely been left out. Hence, the potential role of the energetic disorder in OSCs has received little attention. Interestingly, recently reported state-of-the-art NFA-based devices could achieve a small energetic disorder and high PCE at the same time; and interest in this investigation related to the disorder properties in OSCs was revived. In this contribution, progress in terms of the correlation between molecular design and energetic disorder is reviewed together with their effects on the optoelectronic mechanism and photovoltaic performance. Finally, the specific challenges and possible solutions in reducing the energetic disorder of OSCs from the viewpoint of materials and devices are proposed. Y1 - 2022 U6 - https://doi.org/10.1039/d2ee00271j SN - 1754-5692 SN - 1754-5706 VL - 15 IS - 7 SP - 2806 EP - 2818 PB - Royal Society of Chemistry CY - Cambridge ER - TY - JOUR A1 - Markov, Adrian A1 - Hauser, Lukas A1 - Chaabene, Helmi T1 - Effects of concurrent strength and endurance training on measures of physical fitness in healthy middle-aged and older adults BT - a systematic review with meta-analysis JF - Sports medicine : an international journal of applied medicine and science in sport and exercise N2 - Background There is evidence that in older adults the combination of strength training (ST) and endurance training (ET) (i.e., concurrent training [CT]) has similar effects on measures of muscle strength and cardiorespiratory endurance (CRE) compared with single-mode ST or ET, respectively. Therefore, CT seems to be an effective method to target broad aspects of physical fitness in older adults. Objectives The aim was to examine the effects of CT on measures of physical fitness (i.e., muscle strength, power, balance and CRE) in healthy middle-aged and older adults aged between 50 and 73 years. We also aimed to identify key moderating variables to guide training prescription. Study Design We conducted a systematic review with meta-analysis of randomized controlled trials. Data Sources The electronic databases PubMed, Web of Science Core Collection, MEDLINE and Google Scholar were systematically searched until February 2022. Eligibility Criteria for Selecting Studies We included randomized controlled trials that examined the effects of CT versus passive controls on measures of physical fitness in healthy middle-aged and older adults aged between 50 and 73 years. Results Fifteen studies were eligible, including a total of 566 participants. CT induced moderate positive effects on muscle strength (standardized mean difference [SMD] = 0.74) and power (SMD = 0.50), with a small effect on CRE (SMD = 0.48). However, no significant effects were detected for balance (p > 0.05). Older adults > 65 years (SMD = 1.04) and females (SMD = 1.05) displayed larger improvements in muscle strength compared with adults <= 65 years old (SMD = 0.60) and males (SMD = 0.38), respectively. For CRE, moderate positive effects (SMD = 0.52) were reported in those <= 65 years old only, with relatively larger gains in females (SMD = 0.55) compared with males (SMD = 0.45). However, no significant differences between all subgroups were detected. Independent single training factor analysis indicated larger positive effects of 12 weeks (SMD = 0.87 and 0.88) compared with 21 weeks (SMD = 0.47 and 0.29) of CT on muscle strength and power, respectively, while for CRE, 21 weeks of CT resulted in larger gains (SMD = 0.62) than 12 weeks (SMD = 0.40). For CT frequency, three sessions per week produced larger beneficial effects (SMD = 0.91) on muscle strength compared with four sessions (SMD = 0.55), whereas for CRE, moderate positive effects were only noted after four sessions per week (SMD = 0.58). A session duration of > 30-60 min generated larger improvements in muscle strength (SMD = 0.99) and power (SMD = 0.88) compared with > 60-90 min (SMD = 0.40 and 0.29, respectively). However, for CRE, longer session durations (i.e., > 60-90 min) seem to be more effective (SMD = 0.61) than shorter ones (i.e., > 30-60 min) (SMD = 0.34). ET at moderate-to-near maximal intensities produced moderate (SMD = 0.64) and small positive effects (SMD = 0.49) on muscle strength and CRE, respectively, with no effects at low intensity ET (p > 0.05). Finally, intra-session ST before ET produced larger gains in muscle strength (SMD = 1.00) compared with separate sessions (SMD = 0.55), whereas ET and ST carried out separately induced larger improvements in CRE (SMD = 0.58) compared with intra-session ET before ST (SMD = 0.49). Conclusions CT is an effective method to improve measures of physical fitness (i.e., muscle strength, power, and CRE) in healthy middle-aged and older adults aged between 50 and 73 years, regardless of sex. Results of independent single training factor analysis indicated that the largest effects on muscle strength were observed after 12 weeks of training, > 30-60 min per session, three sessions per week, higher ET intensities and when ST preceded ET within the same session. For CRE, the largest effects were noted after 21 weeks of training, four sessions per week, > 60-90 min per session, higher ET intensities and when ET and ST sessions were performed separately. Regarding muscle power, the largest effects were observed after 12 weeks of training and > 30-60 min per session. Y1 - 2022 U6 - https://doi.org/10.1007/s40279-022-01764-2 SN - 0112-1642 SN - 1179-2035 VL - 53 IS - 2 SP - 437 EP - 455 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Buter, Anuschka A1 - Heckmann, Tobias A1 - Filisetti, Lorenzo A1 - Savi, Sara A1 - Mao, Luca A1 - Gems, Bernhard A1 - Comiti, Francesco T1 - Effects of catchment characteristics and hydro-meteorological scenarios on sediment connectivity in glacierised catchments JF - Geomorphology : an international journal on pure and applied geomorphology N2 - In the past decade, sediment connectivity has become a widely recognized characteristic of a geomorphic system. However, the quantification of functional connectivity (i.e. connectivity which arises due to the actual occurrence of sediment transport processes) and its variation over space and time is still a challenge. In this context, this study assesses the effects of expected future phenomena in the context of climate change (i.e. glacier retreat, permafrost degradation or meteorological extreme events) on sediment transport dynamics in a glacierised Alpine basin. The study area is the Sulden river basin (drainage area 130 km(2)) in the Italian Alps, which is composed of two geomorphologically diverse sub-basins. Based on graph theory, we evaluated the spatio-temporal variations in functional connectivity in these two sub-basins. The graph-object, obtained by manually mapping sediment transport processes between landforms, was adapted to 6 different hydro-meteorological scenarios, which derive from combining base, heatwave and rainstorm conditions with snowmelt and glacier-melt periods. For each scenario and each sub-basin, the sediment transport network and related catchment characteristics were analysed. To compare the effects of the scenarios on functional connectivity, we introduced a connectivity degree, calculated based on the area of the landforms involved in sediment cascades. Results indicate that the area of the basin connected to its outlet in terms of sediment transport might feature a six-fold increase in case of rainstorm conditions compared to "average " meteorological conditions assumed for the base scenario. Furthermore, markedly different effects of climate change on sediment connectivity are expected between the two sub-catchments due to their contrasting morphological and lithological characteristics, in terms of relative importance of rainfall triggered colluvial processes vs temperature-driven proglacial fluvial dynamics. KW - Functional connectivity KW - Graph theory KW - Climate change KW - Geomorphic systems Y1 - 2022 U6 - https://doi.org/10.1016/j.geomorph.2022.108128 SN - 0169-555X SN - 1872-695X VL - 402 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Ndashimye, Felix A1 - Hebie, Oumarou A1 - Tjaden, Jasper T1 - Effectiveness of WhatsApp for measuring migration in follow-up phone surveys BT - lessons from a mode experiment in two low-income countries during COVID contact restrictions JF - Social science computer review N2 - Phone surveys have increasingly become important data collection tools in developing countries, particularly in the context of sudden contact restrictions due to the COVID-19 pandemic. So far, there is limited evidence regarding the potential of the messenger service WhatsApp for remote data collection despite its large global coverage and expanding membership. WhatsApp may offer advantages in terms of reducing panel attrition and cutting survey costs. WhatsApp may offer additional benefits to migration scholars interested in cross-border migration behavior which is notoriously difficult to measure using conventional face-to-face surveys. In this field experiment, we compared the response rates between WhatsApp and interactive voice response (IVR) modes using a sample of 8446 contacts in Senegal and Guinea. At 12%, WhatsApp survey response rates were nearly eight percentage points lower than IVR survey response rates. However, WhatsApp offers higher survey completion rates, substantially lower costs and does not introduce more sample selection bias compared to IVR. We discuss the potential of WhatsApp surveys in low-income contexts and provide practical recommendations for field implementation. KW - WhatsApp KW - survey mode KW - migration KW - Covid KW - phone Y1 - 2022 U6 - https://doi.org/10.1177/08944393221111340 SN - 0894-4393 SN - 1552-8286 PB - Sage CY - Thousand Oaks ER - TY - JOUR A1 - Fühner, Thea Heidi A1 - Granacher, Urs A1 - Golle, Kathleen A1 - Kliegl, Reinhold T1 - Effect of timing of school enrollment on physical fitness in third graders JF - Scientific Reports N2 - Timing of initial school enrollment may vary considerably for various reasons such as early or delayed enrollment, skipped or repeated school classes. Accordingly, the age range within school grades includes older-(OTK) and younger-than-keyage (YTK) children. Hardly any information is available on the impact of timing of school enrollment on physical fitness. There is evidence from a related research topic showing large differences in academic performance between OTK and YTK children versus keyage children. Thus, the aim of this study was to compare physical fitness of OTK (N = 26,540) and YTK (N = 2586) children versus keyage children (N = 108,295) in a representative sample of German third graders. Physical fitness tests comprised cardiorespiratory endurance, coordination, speed, lower, and upper limbs muscle power. Predictions of physical fitness performance for YTK and OTK children were estimated using data from keyage children by taking age, sex, school, and assessment year into account. Data were annually recorded between 2011 and 2019. The difference between observed and predicted z-scores yielded a delta z-score that was used as a dependent variable in the linear mixed models. Findings indicate that OTK children showed poorer performance compared to keyage children, especially in coordination, and that YTK children outperformed keyage children, especially in coordination. Teachers should be aware that OTK children show poorer physical fitness performance compared to keyage children. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-11710-x SN - 2045-2322 VL - 12 SP - 1 EP - 11 PB - Springer Nature CY - London ER - TY - JOUR A1 - Figueroa Campos, Gustavo Adolfo A1 - G. K. T. Kruizenga, Johannes A1 - Sagu Tchewonpi, Sorel A1 - Schwarz, Steffen A1 - Homann, Thomas A1 - Taubert, Andreas A1 - Rawel, Harshadrai Manilal T1 - Effect of the post-harvest processing on protein modification in green coffee beans by phenolic compounds JF - Foods : open access journal N2 - The protein fraction, important for coffee cup quality, is modified during post-harvest treatment prior to roasting. Proteins may interact with phenolic compounds, which constitute the major metabolites of coffee, where the processing affects these interactions. This allows the hypothesis that the proteins are denatured and modified via enzymatic and/or redox activation steps. The present study was initiated to encompass changes in the protein fraction. The investigations were limited to major storage protein of green coffee beans. Fourteen Coffea arabica samples from various processing methods and countries were used. Different extraction protocols were compared to maintain the status quo of the protein modification. The extracts contained about 4–8 µg of chlorogenic acid derivatives per mg of extracted protein. High-resolution chromatography with multiple reaction monitoring was used to detect lysine modifications in the coffee protein. Marker peptides were allocated for the storage protein of the coffee beans. Among these, the modified peptides K.FFLANGPQQGGK.E and R.LGGK.T of the α-chain and R.ITTVNSQK.I and K.VFDDEVK.Q of β-chain were detected. Results showed a significant increase (p < 0.05) of modified peptides from wet processed green beans as compared to the dry ones. The present study contributes to a better understanding of the influence of the different processing methods on protein quality and its role in the scope of coffee cup quality and aroma. View Full-Text KW - Arabica coffee KW - coffee processing KW - protein modification KW - bound phenolic compounds KW - peptide biomarkers KW - LC-MS/MS Y1 - 2022 U6 - https://doi.org/10.3390/foods11020159 SN - 2304-8158 VL - 11 PB - MDPI CY - Basel, Schweiz ET - 2 ER - TY - JOUR A1 - Krstulović, Marija A1 - Rosa, Angelika D. A1 - Ferreira Sanchez, Dario A1 - Libon, Lélia A1 - Albers, Christian A1 - Merkulova, Margarita A1 - Grolimund, Daniel A1 - Irifune, Tetsuo A1 - Wilke, Max T1 - Effect of temperature on the densification of silicate melts to lower earth's mantle conditions JF - Physics of the earth and planetary interiors N2 - Physical properties of silicate melts play a key role for global planetary dynamics, controlling for example volcanic eruption styles, mantle convection and elemental cycling in the deep Earth. They are significantly modified by structural changes at the atomic scale due to external parameters such as pressure and temperature or due to chemistry. Structural rearrangements such as 4- to 6-fold coordination change of Si with increasing depth may profoundly influence melt properties, but have so far mostly been studied at ambient temperature due to experimental difficulties. In order to investigate the structural properties of silicate melts and their densification mechanisms at conditions relevant to the deep Earth's interior, we studied haplo basaltic glasses and melts (albite-diopside composition) at high pressure and temperature conditions in resistively and laser-heated diamond anvil cells using X-ray absorption near edge structure spectroscopy. Samples were doped with 10 wt% of Ge, which is accessible with this experimental technique and which commonly serves as a structural analogue for the network forming cation Si. We acquired spectra on the Ge K edge up to 48 GPa and 5000 K and derived the average Ge-O coordination number NGe-O, and bond distance RGe-O as functions of pressure. Our results demonstrate a continuous transformation from tetrahedral to octahedral coordination between ca. 5 and 30 GPa at ambient temperature. Above 1600 K the data reveal a reduction of the pressure needed to complete conversion to octahedral coordination by ca. 30 %. The results allow us to determine the influence of temperature on the Si coordination number changes in natural melts in the Earth's interior. We propose that the complete transition to octahedral coordination in basaltic melts is reached at about 40 GPa, corresponding to a depth of ca. 1200 km in the uppermost lower mantle. At the core-mantle boundary (2900 km, 130 GPa, 3000 K) the existence of non-buoyant melts has been proposed to explain observed low seismic wave velocity features. Our results highlight that the melt composition can affect the melt density at such extreme conditions and may strongly influence the structural response. KW - Silicate melts KW - Densification KW - High pressure and high temperature; KW - XANES KW - Coordination number KW - Ultra-low velocity zones Y1 - 2022 U6 - https://doi.org/10.1016/j.pepi.2021.106823 SN - 0031-9201 SN - 1872-7395 VL - 323 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Mueller, Steffen A1 - Mueller, Juliane A1 - Stoll, Josefine A1 - Mayer, Frank T1 - Effect of six-week resistance and sensorimotor training on trunk strength and stability in elite adolescent athletes BT - a randomized controlled pilot trial JF - Frontiers in physiology N2 - Intervention in the form of core-specific stability exercises is evident to improve trunk stability. The purpose was to assess the effect of an additional 6 weeks sensorimotor or resistance training on maximum isokinetic trunk strength and response to sudden dynamic trunk loading (STL) in highly trained adolescent athletes. The study was conducted as a single-blind, 3-armed randomized controlled trial. Twenty-four adolescent athletes (14f/10 m, 16 +/- 1 yrs.;178 +/- 10 cm; 67 +/- 11 kg; training sessions/week 15 +/- 5; training h/week 22 +/- 8) were randomized into resistance training (RT; n = 7), sensorimotor training (SMT; n = 10), and control group (CG; n = 7). Athletes were instructed to perform standardized, center-based training for 6 weeks, two times per week, with a duration of 1 h each session. SMT consisted of four different core-specific sensorimotor exercises using instable surfaces. RT consisted of four trunk strength exercises using strength training machines, as well as an isokinetic dynamometer. All participants in the CG received an unspecific heart frequency controlled, ergometer-based endurance training (50 min at max. heart frequency of 130HF). For each athlete, each training session was documented in an individual training diary (e.g., level of SMT exercise; 1RM for strength exercise, pain). At baseline (M1) and after 6 weeks of intervention (M2), participants' maximum strength in trunk rotation (ROM:63 degrees) and flexion/extension (ROM:55 degrees) was tested on an isokinetic dynamometer (concentric/eccentric 30 degrees/s). STL was assessed in eccentric (30 degrees/s) mode with additional dynamometer-induced perturbation as a marker of core stability. Peak torque [Nm] was calculated as the main outcome. The primary outcome measurements (trunk rotation/extension peak torque: con, ecc, STL) were statistically analyzed by means of the two-factor repeated measures analysis of variance (alpha = 0.05). Out of 12 possible sessions, athletes participated between 8 and 9 sessions (SMT: 9 +/- 3; RT: 8 +/- 3; CG: 8 +/- 4). Regarding main outcomes of trunk performance, experimental groups showed no significant pre-post difference for maximum trunk strength testing as well as for perturbation compensation (p > 0.05). It is concluded, that future interventions should exceed 6 weeks duration with at least 2 sessions per week to induce enhanced trunk strength or compensatory response to sudden, high-intensity trunk loading in already highly trained adolescent athletes, regardless of training regime. KW - core KW - training intervention KW - trunk stability KW - exercise KW - perturbation Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.802315 SN - 1664-042X VL - 13 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Arntz, Fabian A1 - Mkaouer, Bessem A1 - Markov, Adrian A1 - Schoenfeld, Brad A1 - Moran, Jason A1 - Ramirez-Campillo, Rodrigo A1 - Behrens, Martin A1 - Baumert, Philipp A1 - Erskine, Robert M. A1 - Hauser, Lukas A1 - Chaabene, Helmi T1 - Effect of plyometric jump training on skeletal muscle hypertrophy in healthy individuals BT - a systematic review with multilevel meta-analysis JF - Frontiers in Physiology N2 - Objective: To examine the effect of plyometric jump training on skeletal muscle hypertrophy in healthy individuals. Methods: A systematic literature search was conducted in the databases PubMed, SPORTDiscus, Web of Science, and Cochrane Library up to September 2021. Results: Fifteen studies met the inclusion criteria. The main overall finding (44 effect sizes across 15 clusters median = 2, range = 1–15 effects per cluster) indicated that plyometric jump training had small to moderate effects [standardised mean difference (SMD) = 0.47 (95% CIs = 0.23–0.71); p < 0.001] on skeletal muscle hypertrophy. Subgroup analyses for training experience revealed trivial to large effects in non-athletes [SMD = 0.55 (95% CIs = 0.18–0.93); p = 0.007] and trivial to moderate effects in athletes [SMD = 0.33 (95% CIs = 0.16–0.51); p = 0.001]. Regarding muscle groups, results showed moderate effects for the knee extensors [SMD = 0.72 (95% CIs = 0.66–0.78), p < 0.001] and equivocal effects for the plantar flexors [SMD = 0.65 (95% CIs = −0.25–1.55); p = 0.143]. As to the assessment methods of skeletal muscle hypertrophy, findings indicated trivial to small effects for prediction equations [SMD = 0.29 (95% CIs = 0.16–0.42); p < 0.001] and moderate-to-large effects for ultrasound imaging [SMD = 0.74 (95% CIs = 0.59–0.89); p < 0.001]. Meta-regression analysis indicated that the weekly session frequency moderates the effect of plyometric jump training on skeletal muscle hypertrophy, with a higher weekly session frequency inducing larger hypertrophic gains [β = 0.3233 (95% CIs = 0.2041–0.4425); p < 0.001]. We found no clear evidence that age, sex, total training period, single session duration, or the number of jumps per week moderate the effect of plyometric jump training on skeletal muscle hypertrophy [β = −0.0133 to 0.0433 (95% CIs = −0.0387 to 0.1215); p = 0.101–0.751]. Conclusion: Plyometric jump training can induce skeletal muscle hypertrophy, regardless of age and sex. There is evidence for relatively larger effects in non-athletes compared with athletes. Further, the weekly session frequency seems to moderate the effect of plyometric jump training on skeletal muscle hypertrophy, whereby more frequent weekly plyometric jump training sessions elicit larger hypertrophic adaptations. KW - muscle tissue KW - muscle strength KW - stretch shortening cycle exercise KW - muscle growth KW - human physical conditioning KW - youth sports KW - aged Y1 - 2022 U6 - https://doi.org/10.3389/fphys.2022.888464 SN - 1664-042X VL - 13 SP - 1 EP - 17 PB - Frontiers CY - Lausanne, Schweiz ET - 888464 ER - TY - JOUR A1 - Chaabene, Helmi A1 - Markov, Adrian A1 - Prieske, Olaf A1 - Moran, Jason A1 - Behrens, Martin A1 - Negra, Yassine A1 - Ramirez-Campillo, Rodrigo A1 - Koch, Ulrike A1 - Mkaouer, Bessem T1 - Effect of flywheel versus traditional resistance training on change of direction performance in male athletes BT - a systematic review with meta-analysis JF - International journal of environmental research and public health : IJERPH N2 - Objective: This study aimed to systematically review and meta-analyze the effect of flywheel resistance training (FRT) versus traditional resistance training (TRT) on change of direction (CoD) performance in male athletes. Methods: Five databases were screened up to December 2021. Results: Seven studies were included. The results indicated a significantly larger effect of FRT compared with TRT (standardized mean difference [SMD] = 0.64). A within-group comparison indicated a significant large effect of FRT on CoD performance (SMD = 1.63). For TRT, a significant moderate effect was observed (SMD = 0.62). FRT of <= 2 sessions/week resulted in a significant large effect (SMD = 1.33), whereas no significant effect was noted for >2 sessions/week. Additionally, a significant large effect of <= 12 FRT sessions (SMD = 1.83) was observed, with no effect of >12 sessions. Regarding TRT, no significant effects of any of the training factors were detected (p > 0.05). Conclusions: FRT appears to be more effective than TRT in improving CoD performance in male athletes. Independently computed single training factor analyses for FRT indicated that <= 2 sessions/week resulted in a larger effect on CoD performance than >2 sessions/week. Additionally, a total of <= 12 FRT sessions induced a larger effect than >12 training sessions. Practitioners in sports, in which accelerative and decelerative actions occur in quick succession to change direction, should regularly implement FRT. KW - human physical conditioning KW - eccentric training KW - strength training KW - athletes KW - sports KW - muscle strength Y1 - 2022 U6 - https://doi.org/10.3390/ijerph19127061 SN - 1661-7827 SN - 1660-4601 VL - 19 IS - 12 PB - MDPI CY - Basel ER - TY - JOUR A1 - Hafner, Verena A1 - Hommel, Bernhard A1 - Kayhan, Ezgi A1 - Lee, Dongheui A1 - Paulus, Markus A1 - Verschoor, Stephan T1 - Editorial: The mechanisms underlying the human minimal self JF - Frontiers in psychology KW - agents KW - self KW - minimal self KW - robotics KW - humanoids KW - cognition Y1 - 2022 U6 - https://doi.org/10.3389/fpsyg.2022.961480 SN - 1664-1078 VL - 13 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Mazzone, Angela A1 - Wachs, Sebastian A1 - Foody, Mairead A1 - Blaya, Catherine T1 - Editorial: A connected or isolated generation? BT - the impact of positive and harmful online communications on children and adolescents' wellbeing JF - Frontiers in education KW - children KW - adolescents KW - wellbeing KW - internet use KW - sharenting KW - cyberbullying KW - onlineharmful experiences KW - COVID-19 pandemic Y1 - 2022 U6 - https://doi.org/10.3389/feduc.2022.999028 SN - 2504-284X VL - 7 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Stockhorst, Stefanie A1 - Overhoff, Jürgen A1 - Corfield, Penelope J. ED - Stockhorst, Stefanie ED - Overhoff, Jürgen ED - Corfield, Penelope J. T1 - Editorial Introduction JF - Human-animal interactions in the eighteenth century : from pests and predators to pets, poems and philosophy Y1 - 2022 SN - 978-90-04-49539-5 SN - 978-90-04-44872-8 U6 - https://doi.org/10.1163/9789004495395_002 SP - 1 EP - 4 PB - Brill CY - Leiden ER - TY - JOUR A1 - Licht, Alexis A1 - Kelson, Julia A1 - Bergel, Shelly J. A1 - Schauer, Andrew J. A1 - Petersen, Sierra Victoria A1 - Capirala, Ashika A1 - Huntington, Katharine W. A1 - Dupont-Nivet, Guillaume A1 - Win, Zaw A1 - Aung, Day Wa T1 - Dynamics of pedogenic carbonate growth in the tropical domain of Myanmar JF - Geochemistry, geophysics, geosystems N2 - Pedogenic carbonate is widespread at mid latitudes where warm and dry conditions favor soil carbonate growth from spring to fall. The mechanisms and timing of pedogenic carbonate formation are more ambiguous in the tropical domain, where long periods of soil water saturation and high soil respiration enhance calcite dissolution. This paper provides stable carbon, oxygen and clumped isotope values from Quaternary and Miocene pedogenic carbonates in the tropical domain of Myanmar, in areas characterized by warm (>18°C) winters and annual rainfall up to 1,700 mm. We show that carbonate growth in Myanmar is delayed to the driest and coldest months of the year by sustained monsoonal rainfall from mid spring to late fall. The range of isotopic variability in Quaternary pedogenic carbonates can be solely explained by temporal changes of carbonate growth within the dry season, from winter to early spring. We propose that high soil moisture year-round in the tropical domain narrows carbonate growth to the driest months and makes it particularly sensitive to the seasonal distribution of rainfall. This sensitivity is also enabled by high winter temperatures, allowing carbonate growth to occur outside the warmest months of the year. This high sensitivity is expected to be more prominent in the geological record during times with higher temperatures and greater expansion of the tropical realm. Clumped isotope temperatures, δ13C and δ18O values of tropical pedogenic carbonates are impacted by changes of both rainfall seasonality and surface temperatures; this sensitivity can potentially be used to track past tropical rainfall distribution. KW - clumped isotopes KW - pedogenic carbonate KW - monsoon Y1 - 2022 U6 - https://doi.org/10.1029/2021GC009929 SN - 1525-2027 VL - 23 IS - 7 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Zeitz, Maria A1 - Haacker, Jan M. A1 - Donges, Jonathan A1 - Albrecht, Torsten A1 - Winkelmann, Ricarda T1 - Dynamic regimes of the Greenland Ice Sheet emerging from interacting melt-elevation and glacial isostatic adjustment feedbacks JF - Earth system dynamics N2 - The stability of the Greenland Ice Sheet under global warming is governed by a number of dynamic processes and interacting feedback mechanisms in the ice sheet, atmosphere and solid Earth. Here we study the long-term effects due to the interplay of the competing melt-elevation and glacial isostatic adjustment (GIA) feedbacks for different temperature step forcing experiments with a coupled ice-sheet and solid-Earth model. Our model results show that for warming levels above 2 degrees C, Greenland could become essentially ice-free within several millennia, mainly as a result of surface melting and acceleration of ice flow. These ice losses are mitigated, however, in some cases with strong GIA feedback even promoting an incomplete recovery of the Greenland ice volume. We further explore the full-factorial parameter space determining the relative strengths of the two feedbacks: our findings suggest distinct dynamic regimes of the Greenland Ice Sheets on the route to destabilization under global warming - from incomplete recovery, via quasi-periodic oscillations in ice volume to ice-sheet collapse. In the incomplete recovery regime, the initial ice loss due to warming is essentially reversed within 50 000 years, and the ice volume stabilizes at 61 %-93 % of the present-day volume. For certain combinations of temperature increase, atmospheric lapse rate and mantle viscosity, the interaction of the GIA feedback and the melt-elevation feedback leads to self-sustained, long-term oscillations in ice-sheet volume with oscillation periods between 74 000 and over 300 000 years and oscillation amplitudes between 15 %-70 % of present-day ice volume. This oscillatory regime reveals a possible mode of internal climatic variability in the Earth system on timescales on the order of 100 000 years that may be excited by or synchronized with orbital forcing or interact with glacial cycles and other slow modes of variability. Our findings are not meant as scenario-based near-term projections of ice losses but rather providing insight into of the feedback loops governing the "deep future" and, thus, long-term resilience of the Greenland Ice Sheet. Y1 - 2022 U6 - https://doi.org/10.5194/esd-13-1077-2022 SN - 2190-4979 SN - 2190-4987 VL - 13 IS - 3 SP - 1077 EP - 1096 PB - Copernicus Publ. CY - Göttingen ER - TY - JOUR A1 - Kastius, Alexander A1 - Schlosser, Rainer T1 - Dynamic pricing under competition using reinforcement learning JF - Journal of revenue and pricing management N2 - Dynamic pricing is considered a possibility to gain an advantage over competitors in modern online markets. The past advancements in Reinforcement Learning (RL) provided more capable algorithms that can be used to solve pricing problems. In this paper, we study the performance of Deep Q-Networks (DQN) and Soft Actor Critic (SAC) in different market models. We consider tractable duopoly settings, where optimal solutions derived by dynamic programming techniques can be used for verification, as well as oligopoly settings, which are usually intractable due to the curse of dimensionality. We find that both algorithms provide reasonable results, while SAC performs better than DQN. Moreover, we show that under certain conditions, RL algorithms can be forced into collusion by their competitors without direct communication. KW - Dynamic pricing KW - Competition KW - Reinforcement learning KW - E-commerce KW - Price collusion Y1 - 2021 U6 - https://doi.org/10.1057/s41272-021-00285-3 SN - 1476-6930 SN - 1477-657X VL - 21 IS - 1 SP - 50 EP - 63 PB - Springer Nature Switzerland AG CY - Cham ER - TY - JOUR A1 - Fredrich, Viktor A1 - Bouncken, Ricarda B. A1 - Tiberius, Victor T1 - Dyadic business model convergence or divergence in alliances? BT - a configurational approach JF - Journal of business research N2 - In this study, we contribute to the scholarly conversation on firm-level business model changes following a neoconfigurational approach. By exploring configurations of business model changes over time, we add the direction of business model changes-namely business model convergence or divergence-as a vital avenue to the business model innovation literature. We identify necessary business model convergence and divergence recipes in a sample of N = 217 strategic dyadic alliances. Firstly, technological proximity emerges as a single precondition to both converging and diverging business models. Secondly, business models between competitors either converge through complementarities or tend not to change relative to each other. Thirdly, equity participation enables business model divergence through co-specialization. We conclude with a discussion of business model trajectories and future research directions. KW - Business model innovation KW - Business model changes KW - Convergence vs KW - divergence KW - Strategic alliances KW - Fuzzy -set qualitative comparative KW - analysis KW - (fsQCA) Y1 - 2022 U6 - https://doi.org/10.1016/j.jbusres.2022.08.046 SN - 0148-2963 SN - 1873-7978 VL - 153 SP - 300 EP - 308 PB - Elsevier CY - New York ER - TY - JOUR A1 - Fredrich, Viktor A1 - Bouncken, Ricarda B. A1 - Tiberius, Victor T1 - Dyadic business model convergence or divergence in alliances? BT - a configurational approach JF - Journal of business research N2 - In this study, we contribute to the scholarly conversation on firm-level business model changes following a neoconfigurational approach. By exploring configurations of business model changes over time, we add the direction of business model changes—namely business model convergence or divergence—as a vital avenue to the business model innovation literature. We identify necessary business model convergence and divergence recipes in a sample of N = 217 strategic dyadic alliances. Firstly, technological proximity emerges as a single pre-condition to both converging and diverging business models. Secondly, business models between competitors either converge through complementarities or tend not to change relative to each other. Thirdly, equity participation enables business model divergence through co-specialization. We conclude with a discussion of business model trajectories and future research directions. Y1 - 2022 U6 - https://doi.org/10.1016/j.jbusres.2022.08.046 SN - 0148-2963 VL - 153 SP - 300 EP - 308 PB - Elsevier CY - New York ER - TY - JOUR A1 - Kühne, Katharina A1 - Fischer, Martin H. A1 - Jeglinski-Mende, Melinda A. T1 - During the COVID-19 pandemic participants prefer settings with a face mask, no interaction and at a closer distance JF - Scientific Reports N2 - Peripersonal space is the space surrounding our body, where multisensory integration of stimuli and action execution take place. The size of peripersonal space is flexible and subject to change by various personal and situational factors. The dynamic representation of our peripersonal space modulates our spatial behaviors towards other individuals. During the COVID-19 pandemic, this spatial behavior was modified by two further factors: social distancing and wearing a face mask. Evidence from offline and online studies on the impact of a face mask on pro-social behavior is mixed. In an attempt to clarify the role of face masks as pro-social or anti-social signals, 235 observers participated in the present online study. They watched pictures of two models standing at three different distances from each other (50, 90 and 150 cm), who were either wearing a face mask or not and were either interacting by initiating a hand shake or just standing still. The observers’ task was to classify the model by gender. Our results show that observers react fastest, and therefore show least avoidance, for the shortest distances (50 and 90 cm) but only when models wear a face mask and do not interact. Thus, our results document both pro- and anti-social consequences of face masks as a result of the complex interplay between social distancing and interactive behavior. Practical implications of these findings are discussed. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-16730-1 SN - 2045-2322 VL - 12 SP - 1 EP - 12 PB - Springer Nature CY - Berlin ER - TY - JOUR A1 - Irrgang, Anna M. A1 - Bendixen, Mette A1 - Farquharson, Louise M. A1 - Baranskaya, Alisa A1 - Erikson, Li H. A1 - Gibbs, Ann E. A1 - Ogorodov, Stanislav A. A1 - Overduin, Pier Paul A1 - Lantuit, Hugues A1 - Grigoriev, Mikhail N. A1 - Jones, Benjamin M. T1 - Drivers, dynamics and impacts of changing Arctic coasts JF - Nature reviews earth and environment N2 - Arctic coasts are vulnerable to the effects of climate change, including rising sea levels and the loss of permafrost, sea ice and glaciers. Assessing the influence of anthropogenic warming on Arctic coastal dynamics, however, is challenged by the limited availability of observational, oceanographic and environmental data. Yet, with the majority of permafrost coasts being erosive, coupled with projected intensification of erosion and flooding, understanding these changes is critical. In this Review, we describe the morphological diversity of Arctic coasts, discuss important drivers of coastal change, explain the specific sensitivity of Arctic coasts to climate change and provide an overview of pan-Arctic shoreline change and its multifaceted impacts. Arctic coastal changes impact the human environment by threatening coastal settlements, infrastructure, cultural sites and archaeological remains. Changing sediment fluxes also impact the natural environment through carbon, nutrient and pollutant release on a magnitude that remains difficult to predict. Increasing transdisciplinary and interdisciplinary collaboration efforts will build the foundation for identifying sustainable solutions and adaptation strategies to reduce future risks for those living on, working at and visiting the rapidly changing Arctic coast. Y1 - 2022 U6 - https://doi.org/10.1038/s43017-021-00232-1 SN - 2662-138X VL - 3 IS - 1 SP - 39 EP - 54 PB - Nature Research CY - London ER - TY - JOUR A1 - Klein, Konstantin A1 - Lantuit, Hugues A1 - Rolph, Rebecca T1 - Drivers of Turbidity and Its Seasonal Variability at Herschel Island Qikiqtaruk (Western Canadian Arctic) JF - Water / Molecular Diversity Preservation International (MDPI) N2 - The Arctic is greatly affected by climate change. Increasing air temperatures drive permafrost thaw and an increase in coastal erosion and river discharge. This results in a greater input of sediment and organic matter into nearshore waters, impacting ecosystems by reducing light transmission through the water column and altering biogeochemistry. This potentially results in impacts on the subsistence economy of local people as well as the climate due to the transformation of suspended organic matter into greenhouse gases. Even though the impacts of increased suspended sediment concentrations and turbidity in the Arctic nearshore zone are well-studied, the mechanisms underpinning this increase are largely unknown. Wave energy and tides drive the level of turbidity in the temperate and tropical parts of the world, and this is generally assumed to also be the case in the Arctic. However, the tidal range is considerably lower in the Arctic, and processes related to the occurrence of permafrost have the potential to greatly contribute to nearshore turbidity. In this study, we use high-resolution satellite imagery alongside in situ and ERA5 reanalysis data of ocean and climate variables in order to identify the drivers of nearshore turbidity, along with its seasonality in the nearshore waters of Herschel Island Qikiqtaruk, in the western Canadian Arctic. Nearshore turbidity correlates well to wind direction, wind speed, significant wave height, and wave period. Nearshore turbidity is superiorly correlated to wind speed at the Beaufort Shelf compared to in situ measurements at Herschel Island Qikiqtaruk, showing that nearshore turbidity, albeit being of limited spatial extent, is influenced by large-scale weather and ocean phenomenons. We show that, in contrast to the temperate and tropical ocean, freshly eroded material is the predominant driver of nearshore turbidity in the Arctic, rather than resuspension, which is caused by the vulnerability of permafrost coasts to thermo-erosion. KW - ocean color remote sensing KW - Arctic ocean KW - suspended sediment KW - Landsat KW - Sentinel 2 KW - ERA5 KW - nearshore zone Y1 - 2022 U6 - https://doi.org/10.3390/w14111751 SN - 2073-4441 VL - 14 SP - 1 EP - 13 PB - MDPI CY - Basel, Schweiz ET - 11 ER - TY - JOUR A1 - Vogel, Johannes T1 - Drivers of phenological changes in southern Europe JF - International Journal of Biometeorology N2 - The life cycle of plants is largely determined by climate, which renders phenological responses to climate change a highly suitable bioindicator of climate change. Yet, it remains unclear, which are the key drivers of phenological patterns at certain life stages. Furthermore, the varying responses of species belonging to different plant functional types are not fully understood. In this study, the role of temperature and precipitation as environmental drivers of phenological changes in southern Europe is assessed. The trends of the phenophases leaf unfolding, flowering, fruiting, and senescence are quantified, and the corresponding main environmental drivers are identified. A clear trend towards an earlier onset of leaf unfolding, flowering, and fruiting is detected, while there is no clear pattern for senescence. In general, the advancement of leaf unfolding, flowering and fruiting is smaller for deciduous broadleaf trees in comparison to deciduous shrubs and crops. Many broadleaf trees are photoperiod-sensitive; therefore, their comparatively small phenological advancements are likely the effect of photoperiod counterbalancing the impact of increasing temperatures. While temperature is identified as the main driver of phenological changes, precipitation also plays a crucial role in determining the onset of leaf unfolding and flowering. Phenological phases advance under dry conditions, which can be linked to the lack of transpirational cooling leading to rising temperatures, which subsequently accelerate plant growth. KW - Phenology KW - Southern Europe KW - Plant functional types KW - Linear mixed effect model KW - Climate change Y1 - 2022 U6 - https://doi.org/10.1007/s00484-022-02331-0 SN - 0020-7128 SN - 1432-1254 VL - 66 IS - 9 SP - 1903 EP - 1914 PB - Springer CY - New York ER - TY - JOUR A1 - Sarabadani, Jalal A1 - Metzler, Ralf A1 - Ala-Nissila, Tapio T1 - Driven polymer translocation into a channel: Isoflux tension propagation theory and Langevin dynamics simulations JF - Physical Review Research N2 - Isoflux tension propagation (IFTP) theory and Langevin dynamics (LD) simulations are employed to study the dynamics of channel-driven polymer translocation in which a polymer translocates into a narrow channel and the monomers in the channel experience a driving force fc. In the high driving force limit, regardless of the channel width, IFTP theory predicts τ ∝ f βc for the translocation time, where β = −1 is the force scaling exponent. Moreover, LD data show that for a very narrow channel fitting only a single file of monomers, the entropic force due to the subchain inside the channel does not play a significant role in the translocation dynamics and the force exponent β = −1 regardless of the force magnitude. As the channel width increases the number of possible spatial configurations of the subchain inside the channel becomes significant and the resulting entropic force causes the force exponent to drop below unity. Y1 - 2022 U6 - https://doi.org/10.1103/PhysRevResearch.4.033003 SN - 2643-1564 VL - 4 SP - 033003-1 EP - 033003-14 PB - American Physical Society CY - College Park, Maryland, USA ET - 3 ER - TY - JOUR A1 - Caliendo, Marco A1 - Hennecke, Juliane T1 - Drinking is different! BT - examining the role of locus of control for alcohol consumption JF - Empirical economics N2 - Locus of control (LOC) measures how much an individual believes in the causal relationship between her own actions and her life’s outcomes. While earlier literature has shown that an increasing internal LOC is associated with increased health-conscious behavior in domains such as smoking, exercise or diets, we find that drinking seems to be different. Using very informative German panel data, we extend and generalize previous findings and find a significant positive association between having an internal LOC and the probability of occasional and regular drinking for men and women. An increase in an individual’s LOC by one standard deviation increases the probability of occasional or regular drinking on average by 3.4% for men and 6.9% for women. Using a decomposition method, we show that roughly a quarter of this association can be explained by differences in the social activities between internal and external individuals. KW - locus of control KW - alcohol consumption KW - health behavior KW - risk perception KW - social activity Y1 - 2022 U6 - https://doi.org/10.1007/s00181-022-02219-3 SN - 0377-7332 SN - 1435-8921 VL - 63 IS - 5 SP - 2785 EP - 2815 PB - Springer CY - Berlin ER - TY - JOUR A1 - Bartholomäus, Alexander A1 - Lipus, Daniel A1 - Mitzscherling, Julia A1 - MacLean, Joana A1 - Wagner, Dirk T1 - Draft Genome Sequence of Nocardioides alcanivorans NGK65(T), a Hexadecane-Degrading Bacterium JF - Microbiology Resource Announcements N2 - The Gram-positive bacterium Nocardioides alcanivorans NGK65(T) was isolated from plastic-polluted soil and cultivated on medium with polyethylene as the single carbon source. Nanopore sequencing revealed the presence of candidate enzymes for the biodegradation of polyethylene. Here, we report the draft genome of this newly described member of the terrestrial plastisphere. Y1 - 2022 U6 - https://doi.org/10.1128/mra.01213-21 SN - 2576-098X VL - 11 IS - 8 PB - American Society for Microbiology CY - Washington ER - TY - JOUR A1 - Li, Xiaoping A1 - Apriyanto, Ardha A1 - Flores Castellanos, Junio A1 - Compart, Julia A1 - Muntaha, Sidratul Nur A1 - Fettke, Jörg T1 - Dpe2/phs1 revealed unique starch metabolism with three distinct phases characterized by different starch granule numbers per chloroplast, allowing insights into the control mechanism of granule number regulation by gene co-regulation and metabolic profiling JF - Frontiers in Plant Science N2 - An Arabidopsis mutant lacking both the cytosolic Disproportionating enzyme 2 (DPE2) and the plastidial glucan Phosphorylase 1 (PHS1) revealed a unique starch metabolism. Dpe2/phs1 has been reported to have only one starch granule number per chloroplast when grown under diurnal rhythm. For this study, we analyzed dpe2/phs1 in details following the mutant development, and found that it showed three distinct periods of granule numbers per chloroplast, while there was no obvious change observed in Col-0. In young plants, the starch granule number was similar to that in Col-0 at first, and then decreased significantly, down to one or no granule per chloroplast, followed by an increase in the granule number. Thus, in dpe2/phs1, control over the starch granule number is impaired, but it is not defective in starch granule initiation. The data also indicate that the granule number is not fixed, and is regulated throughout plant growth. Furthermore, the chloroplasts revealed alterations during these three periods, with a partially strong aberrant morphology in the middle phase. Interestingly, the unique metabolism was perpetuated when starch degradation was further impaired through an additional lack of Isoamylase 3 (ISA3) or Starch excess 4 (SEX4). Transcriptomic studies and metabolic profiling revealed the co-regulation of starch metabolism-related genes and a clear metabolic separation between the periods. Most senescence-induced genes were found to be up-regulated more than twice in the starch-less mature leaves. Thus, dpe2/phs1 is a unique plant material source, with which we may study starch granule number regulation to obtain a more detailed understanding. KW - LCSM KW - RNA-Seq KW - metabolic-profiling KW - starch granule number regulation KW - starch initiation KW - starch degradation Y1 - 2022 U6 - https://doi.org/10.3389/fpls.2022.1039534 SN - 1664-462X SP - 1 EP - 16 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Hering, Robert A1 - Hauptfleisch, Morgan A1 - Jago, Mark A1 - Smith, Taylor A1 - Kramer-Schadt, Stephanie A1 - Stiegler, Jonas A1 - Blaum, Niels T1 - Don't stop me now: Managed fence gaps could allow migratory ungulates to track dynamic resources and reduce fence related energy loss JF - Frontiers in Ecology and Evolution N2 - In semi-arid environments characterized by erratic rainfall and scattered primary production, migratory movements are a key survival strategy of large herbivores to track resources over vast areas. Veterinary Cordon Fences (VCFs), intended to reduce wildlife-livestock disease transmission, fragment large parts of southern Africa and have limited the movements of large wild mammals for over 60 years. Consequently, wildlife-fence interactions are frequent and often result in perforations of the fence, mainly caused by elephants. Yet, we lack knowledge about at which times fences act as barriers, how fences directly alter the energy expenditure of native herbivores, and what the consequences of impermeability are. We studied 2-year ungulate movements in three common antelopes (springbok, kudu, eland) across a perforated part of Namibia's VCF separating a wildlife reserve and Etosha National Park using GPS telemetry, accelerometer measurements, and satellite imagery. We identified 2905 fence interaction events which we used to evaluate critical times of encounters and direct fence effects on energy expenditure. Using vegetation type-specific greenness dynamics, we quantified what animals gained in terms of high quality food resources from crossing the VCF. Our results show that the perforation of the VCF sustains herbivore-vegetation interactions in the savanna with its scattered resources. Fence permeability led to peaks in crossing numbers during the first flush of woody plants before the rain started. Kudu and eland often showed increased energy expenditure when crossing the fence. Energy expenditure was lowered during the frequent interactions of ungulates standing at the fence. We found no alteration of energy expenditure when springbok immediately found and crossed fence breaches. Our results indicate that constantly open gaps did not affect energy expenditure, while gaps with obstacles increased motion. Closing gaps may have confused ungulates and modified their intended movements. While browsing, sedentary kudu's use of space was less affected by the VCF; migratory, mixed-feeding springbok, and eland benefited from gaps by gaining forage quality and quantity after crossing. This highlights the importance of access to vast areas to allow ungulates to track vital vegetation patches. KW - veterinary cordon fence KW - ungulate KW - fence ecology KW - resource-tracking KW - energy expenditure KW - accelerometer KW - GPS KW - wildlife and habitat management Y1 - 2022 U6 - https://doi.org/10.3389/fevo.2022.907079 SN - 2296-701X SP - 1 EP - 18 PB - Frontiers CY - Lausanne, Schweiz ER - TY - JOUR A1 - Zimmermann, Andreas A1 - Schabedoth, John Alexander T1 - Domestic and international criminal justice BT - challenges ahead JF - KFG working paper series N2 - This paper consists of two parts: In the first part, some of the challenges with which the Internationaal Criminal Court is currently confronted are being presented. First of all, the article will describe the current state of the International Criminal Court and the Rome Statue. Afterwards, the article analyses the Court’s efforts to deal with cases against third-country nationals and the challenges it is facing in that regard. In addition, the Court’s case law will be analyzed in order to determine an increasing ‘emancipation’ of the case law of the International Criminal Court from international humanitarian law. The second part of the paper will briefly discuss the role of domestic international criminal law and domestic courts in the further development and enforcement of international criminal law. As an example of the role that domestic courts may have in clarifying classic issues in international law, the judgment of the German Supreme Court of January 28, 2021 (3 StR 564/19), which deals with the status of costumary international law on functional immunity of State officials before domestic courts, shall be assessed. Y1 - 2022 U6 - https://doi.org/10.2139/ssrn.4087189 SN - 2509-3762 SN - 2509-3770 IS - 57 PB - Berlin Potsdam Research Group International Law - Rise or Decline? CY - Berlin ER - TY - JOUR A1 - Ewelt-Knauer, Corinna A1 - Schwering, Anja A1 - Winkelmann, Sandra T1 - Doing good by doing bad BT - How tone at the top and tone at the bottom impact performance-improving noncompliant behavior JF - Journal of business ethics N2 - This study investigates how tone at the top, implemented by top management, and tone at the bottom, in an employee’s immediate work environment, determine noncompliance. We focus on the disallowed actions of employees that improve their own and, in turn, the company’s performance, referred to as performance-improving noncompliant behavior (PINC behavior). We conduct a survey of German sales employees to investigate specifically how, on the one hand, (1) corporate rules and (2) performance pressure, both implemented by top management, and, on the other hand, (3) others’ PINC expectations and (4) others’ PINC behavior, both arising from the employee’s immediate work environment, influence PINC behavior. When considered in isolation, we find that corporate rules, as top management’s main instrument to guide employee behavior, decrease employee PINC behavior. However, this effect is negatively influenced by the employees’ immediate work environment when employees are expected to engage in PINC or when others engage in PINC. In contrast, even though top management places great performance pressure on employees, that by itself does not increase PINC behavior. Overall, our study informs practitioners and researchers about whether and how the four determinants increase or decrease employees’ PINC behavior, which is important to comprehend triggers and to counteract such misconduct. KW - noncompliance KW - tone at the top KW - tone at the bottom KW - corporate rules KW - performance pressure KW - others’ expectations KW - 0thers’ behavior Y1 - 2020 U6 - https://doi.org/10.1007/s10551-020-04647-6 SN - 0167-4544 SN - 1573-0697 VL - 175 IS - 3 SP - 609 EP - 624 PB - Springer CY - Dordrecht ER - TY - JOUR A1 - Scharf, Christina A1 - Weinelt, Ferdinand Anton A1 - Schroeder, Ines A1 - Paal, Michael A1 - Weigand, Michael A1 - Zoller, Michael A1 - Irlbeck, Michael A1 - Kloft, Charlotte A1 - Briegel, Josef A1 - Liebchen, Uwe T1 - Does the cytokine adsorber CytoSorb (R) reduce vancomycin exposure in critically ill patients with sepsis or septic shock? BT - a prospective observational study JF - Annals of intensive care N2 - Background: Hemadsorption of cytokines is used in critically ill patients with sepsis or septic shock. Concerns have been raised that the cytokine adsorber CytoSorb (R) unintentionally adsorbs vancomycin. This study aimed to quantify vancomycin elimination by CytoSorb (R) . Methods: Critically ill patients with sepsis or septic shock receiving continuous renal replacement therapy and CytoSorb (R) treatment during a prospective observational study were included in the analysis. Vancomycin pharmacokinetics was characterized using population pharmacokinetic modeling. Adsorption of vancomycin by the CytoSorb (R) was investigated as linear or saturable process. The final model was used to derive dosing recommendations based on stochastic simulations. Results: 20 CytoSorb (R) treatments in 7 patients (160 serum samples/24 during CytoSorb (R)-treatment, all continuous infusion) were included in the study. A classical one-compartment model, including effluent flow rate of the continuous hemodialysis as linear covariate on clearance, best described the measured concentrations (without CytoSorb (R)). Significant adsorption with a linear decrease during CytoSorb (R) treatment was identified (p <0.0001) and revealed a maximum increase in vancomycin clearance of 291% (initially after CytoSorb (R) installation) and a maximum adsorption capacity of 572 mg. For a representative patient of our cohort a reduction of the area under the curve (AUC) by 93 mg/L*24 h during CytoSorb (R) treatment was observed. The additional administration of 500 mg vancomycin over 2 h during CytoSorb (R) attenuated the effect and revealed a negligible reduction of the AUC by 4 mg/L*24h. Conclusion: We recommend the infusion of 500 mg vancomycin over 2 h during CytoSorb (R) treatment to avoid subtherapeutic concentrations. KW - Vancomycin KW - Critically ill patients KW - CytoSorb (R) KW - Sepsis; KW - Pharmacokinetics KW - Adsorption Y1 - 2022 U6 - https://doi.org/10.1186/s13613-022-01017-5 SN - 2110-5820 VL - 12 IS - 1 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Meier, Adrian A1 - Krause, Hannes-Vincent T1 - Does passive social media use harm well-being? BT - an adversarial review JF - Journal of media psychology N2 - Research into the effects of social media on well-being often distinguishes “active” and “passive” use, with passive use supposedly more harmful to well-being (i.e., the passive use hypothesis). Recently, several studies and reviews have begun to question this hypothesis and its conceptual basis, the active/passive dichotomy. As this dichotomy has become a staple of social media research but evidence challenging its validity is mounting, a comprehensive debate on its pros, cons, and potential future is needed. This adversarial review brings together two voices – one more supportive, and the other more critical – toward the active/passive model. In constructive dialogue, we summarize and contrast our two opposing positions: The first position argues that the active/passive dichotomy is a useful framework because it adequately describes how and why passive use is (more) harmful for well-being. The second position challenges the validity of the dichotomy and the passive use hypothesis specifically. Arguments are presented alongside (a) the empirical basis, (b) conceptualization, and (c) operationalization of active and passive use, with particular focus on the passive use hypothesis. Rather than offering a conciliatory summary of the status quo, the goal of this review is to carve out key points of friction in the literature on the effects of social media through fruitful debate. We summarize our main agreements and unresolved disagreements on the merits and shortcomings of the active/passive dichotomy. In doing so, this review paves the way for researchers to decide whether and how they want to continue applying this lens in their future work. KW - social media KW - active/passive dichotomy KW - well-being KW - adversarial review Y1 - 2022 U6 - https://doi.org/10.1027/1864-1105/a000358 SN - 1864-1105 SN - 2151-2388 VL - 35 IS - 3 SP - 169 EP - 180 PB - Hogrefe CY - Göttingen ER - TY - JOUR A1 - Poltz, Nadine A1 - Quandte, Sabine A1 - Kohn, Juliane A1 - Kucian, Karin A1 - Wyschkon, Anne A1 - von Aster, Michael A1 - Esser, Günter T1 - Does It Count? Pre-School Children’s Spontaneous Focusing on Numerosity and Their Development of Arithmetical Skills at School JF - Brain Sciences N2 - Background: Children’s spontaneous focusing on numerosity (SFON) is related to numerical skills. This study aimed to examine (1) the developmental trajectory of SFON and (2) the interrelations between SFON and early numerical skills at pre-school as well as their influence on arithmetical skills at school. Method: Overall, 1868 German pre-school children were repeatedly assessed until second grade. Nonverbal intelligence, visual attention, visuospatial working memory, SFON and numerical skills were assessed at age five (M = 63 months, Time 1) and age six (M = 72 months, Time 2), and arithmetic was assessed at second grade (M = 95 months, Time 3). Results: SFON increased significantly during pre-school. Path analyses revealed interrelations between SFON and several numerical skills, except number knowledge. Magnitude estimation and basic calculation skills (Time 1 and Time 2), and to a small degree number knowledge (Time 2), contributed directly to arithmetic in second grade. The connection between SFON and arithmetic was fully mediated by magnitude estimation and calculation skills at pre-school. Conclusion: Our results indicate that SFON first and foremost influences deeper understanding of numerical concepts at pre-school and—in contrast to previous findings –affects only indirectly children’s arithmetical development at school. KW - SFON KW - school mathematics KW - mathematical precursor KW - counting KW - number knowledge KW - magnitude estimation KW - transformation KW - pre-school KW - longitudinal KW - development Y1 - 2022 U6 - https://doi.org/10.3390/brainsci12030313 SN - 2076-3425 VL - 12 SP - 1 EP - 18 PB - MDPI CY - Basel, Schweiz ET - 3 ER - TY - JOUR A1 - Stone, Kate A1 - Vasishth, Shravan A1 - Malsburg, Titus von der T1 - Does entropy modulate the prediction of German long-distance verb particles? JF - PLOS ONE N2 - In this paper we examine the effect of uncertainty on readers’ predictions about meaning. In particular, we were interested in how uncertainty might influence the likelihood of committing to a specific sentence meaning. We conducted two event-related potential (ERP) experiments using particle verbs such as turn down and manipulated uncertainty by constraining the context such that readers could be either highly certain about the identity of a distant verb particle, such as turn the bed […] down, or less certain due to competing particles, such as turn the music […] up/down. The study was conducted in German, where verb particles appear clause-finally and may be separated from the verb by a large amount of material. We hypothesised that this separation would encourage readers to predict the particle, and that high certainty would make prediction of a specific particle more likely than lower certainty. If a specific particle was predicted, this would reflect a strong commitment to sentence meaning that should incur a higher processing cost if the prediction is wrong. If a specific particle was less likely to be predicted, commitment should be weaker and the processing cost of a wrong prediction lower. If true, this could suggest that uncertainty discourages predictions via an unacceptable cost-benefit ratio. However, given the clear predictions made by the literature, it was surprisingly unclear whether the uncertainty manipulation affected the two ERP components studied, the N400 and the PNP. Bayes factor analyses showed that evidence for our a priori hypothesised effect sizes was inconclusive, although there was decisive evidence against a priori hypothesised effect sizes larger than 1μV for the N400 and larger than 3μV for the PNP. We attribute the inconclusive finding to the properties of verb-particle dependencies that differ from the verb-noun dependencies in which the N400 and PNP are often studied. Y1 - 2022 U6 - https://doi.org/10.1371/journal.pone.0267813 SN - 1932-6203 SP - 1 EP - 25 PB - PLOS ONE CY - San Francisco, California, US ER - TY - JOUR A1 - Stone, Kate A1 - Vasishth, Shravan A1 - von der Malsburg, Titus Raban T1 - Does entropy modulate the prediction of German long-distance verb particles? JF - PLOS ONE N2 - In this paper we examine the effect of uncertainty on readers' predictions about meaning. In particular, we were interested in how uncertainty might influence the likelihood of committing to a specific sentence meaning. We conducted two event-related potential (ERP) experiments using particle verbs such as turn down and manipulated uncertainty by constraining the context such that readers could be either highly certain about the identity of a distant verb particle, such as turn the bed [...] down, or less certain due to competing particles, such as turn the music [...] up/down. The study was conducted in German, where verb particles appear clause-finally and may be separated from the verb by a large amount of material. We hypothesised that this separation would encourage readers to predict the particle, and that high certainty would make prediction of a specific particle more likely than lower certainty. If a specific particle was predicted, this would reflect a strong commitment to sentence meaning that should incur a higher processing cost if the prediction is wrong. If a specific particle was less likely to be predicted, commitment should be weaker and the processing cost of a wrong prediction lower. If true, this could suggest that uncertainty discourages predictions via an unacceptable cost-benefit ratio. However, given the clear predictions made by the literature, it was surprisingly unclear whether the uncertainty manipulation affected the two ERP components studied, the N400 and the PNP. Bayes factor analyses showed that evidence for our a priori hypothesised effect sizes was inconclusive, although there was decisive evidence against a priori hypothesised effect sizes larger than 1 mu Vfor the N400 and larger than 3 mu V for the PNP. We attribute the inconclusive finding to the properties of verb-particle dependencies that differ from the verb-noun dependencies in which the N400 and PNP are often studied. Y1 - 2022 U6 - https://doi.org/10.1371/journal.pone.0267813 SN - 1932-6203 VL - 17 IS - 8 PB - PLOS CY - San Francisco, California, US ER - TY - JOUR A1 - Monod, Emmanuel A1 - Lissillour, Raphael A1 - Köster, Antonia A1 - Jiayin, Qi T1 - Does AI control or support? BT - power shifts after AI system implementation in customer relationship management JF - Journal of decision systems N2 - Many companies are currently investing in artificial intelligence (AI) because of its potential to increase customer satisfaction or financial performance. However, the success rates in implementing AI systems are low, partly due to technology-centric approaches that neglect work practices. This study draws on Bourdieu’s theory of practice to highlight the potential power shift related to AI in customer relationship management, based on the concepts field, capital, and habitus. Two longitudinal case studies were conducted to understand the power shift related to AI implementation. These two AI systems were designed with the objective to support employees. However, subsequently, their implementation changed the balance of power with a significant shift towards more management control, resulting in a devaluation of employees’ work practices. The paper discusses implications for theory and practice in terms of the discrepancies and power shifts following the introduction of AI systems to support customer relationship management. KW - artificial intelligence KW - customer relationship management KW - theory of practice KW - field of power KW - social capital KW - economic capital KW - cultural capital KW - symbolic capital KW - habitus Y1 - 2022 U6 - https://doi.org/10.1080/12460125.2022.2066051 SN - 1246-0125 SN - 2116-7052 VL - 32 IS - 3 SP - 542 EP - 565 PB - Taylor & Francis CY - Abingdon ER - TY - JOUR A1 - Fatfouta, Ramzi A1 - Heinze, Peter Eric T1 - Do bigger egos mean bigger presence? Facets of grandiose narcissism and mindfulness JF - Current Psychology N2 - Broad sections of the population try to be more mindful, often with quite self-centered motives. It is therefore not surprising that there is growing interest in the investigation of narcissism and mindfulness. Despite theoretical and empirical ties, however, existing research on this association is scarce. In two studies (N = 3,134 and 403) with English- and German-speaking participants, we apply structural equation modeling (SEM) to examine the relationships between facets of grandiose narcissism and trait mindfulness. Across both studies and, using different narcissism and mindfulness measures, SEM consistently revealed opposing patterns for agentic and antagonistic narcissism, with agentic narcissism being positively related to trait mindfulness, and antagonistic narcissism being negatively related to it. Findings highlight the necessity to acknowledge the conceptual heterogeneity of narcissism when examining its relationship with trait mindfulness. Practical implications regarding how agentic and antagonistic narcissists might profit differently from mindfulness practice are discussed. KW - Narcissism KW - Mindfulness KW - Meditation KW - Structural equation modeling KW - Self-enhancement Y1 - 2022 U6 - https://doi.org/10.1007/s12144-022-03115-w SN - 1046-1310 SN - 1936-4733 VL - 42 SP - 19795 EP - 19807 PB - Springer CY - New York ER - TY - JOUR A1 - Kiemel, Katrin A1 - Weithoff, Guntram A1 - Tiedemann, Ralph T1 - DNA metabarcoding reveals impact of local recruitment, dispersal, and hydroperiod on assembly of a zooplankton metacommunity JF - Molecular ecology N2 - Understanding the environmental impact on the assembly of local communities in relation to their spatial and temporal connectivity is still a challenge in metacommunity ecology. This study aims to unravel underlying metacommunity processes and environmental factors that result in observed zooplankton communities. Unlike most metacommunity studies, we jointly examine active and dormant zooplankton communities using a DNA metabarcoding approach to overcome limitations of morphological species identification. We applied two-fragment (COI and 18S) metabarcoding to monitor communities of 24 kettle holes over a two-year period to unravel (i) spatial and temporal connectivity of the communities, (ii) environmental factors influencing local communities, and (iii) dominant underlying metacommunity processes in this system. We found a strong separation of zooplankton communities from kettle holes of different hydroperiods (degree of permanency) throughout the season, while the community composition within single kettle holes did not differ between years. Species richness was primarily dependent on pH and permanency, while species diversity (Shannon Index) was influenced by kettle hole location. Community composition was impacted by kettle hole size and surrounding field crops. Environmental processes dominated temporal and spatial processes. Sediment communities showed a different composition compared to water samples but did not differ between ephemeral and permanent kettle holes. Our results suggest that communities are mainly structured by environmental filtering based on pH, kettle hole size, surrounding field crops, and permanency. Environmental filtering based on specific conditions in individual kettle holes seems to be the dominant process in community assembly in the studied zooplankton metacommunity. KW - bulk DNA KW - dispersal KW - DNA-metabarcoding KW - environmental filtering; KW - metacommunity KW - zooplankton Y1 - 2022 U6 - https://doi.org/10.1111/mec.16627 SN - 0962-1083 SN - 1365-294X VL - 32 IS - 23 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Heinzel, Mirko T1 - Divided loyalties? BT - the role of national IO staff in aid–funded procurement JF - Governance N2 - Many operational International Organizations (IOs) rely on national staff when implementing projects in member states. However, fears persist that the loyalties of national IO staff may be divided when working in their home countries. The article studies differences in more than 50,000 procurement decisions taken in 1729 projects overseen by World Bank staff working as expatriates or in their home countries. The empirical results show that when staff work in their home countries, national suppliers' probability of winning procurement contracts increases. However, these increases are not driven by restricted procurement processes—that exclude competition—which are often seen as red flags for corruption. Instead, restricted procurement processes seem to be less likely when staff work in their home countries. These findings imply that national IO staff use their country-specific knowledge to increase the development effectiveness of procurement in line with the mandate of the World Bank. Y1 - 2021 U6 - https://doi.org/10.1111/gove.12650 SN - 0952-1895 SN - 1468-0491 VL - 35 IS - 4 SP - 1183 EP - 1203 PB - Wiley-Blackwell CY - Oxford ER - TY - JOUR A1 - Fuhrmeister, Pamela A1 - Bürki-Foschini, Audrey Damaris T1 - Distributional properties of semantic interference in picture naming BT - Bayesian meta-analyses JF - Psychonomic bulletin & review : a journal of the Psychonomic Society N2 - Studies of word production often make use of picture-naming tasks, including the picture-word-interference task. In this task, participants name pictures with superimposed distractor words. They typically need more time to name pictures when the distractor word is semantically related to the picture than when it is unrelated (the semantic interference effect). The present study examines the distributional properties of this effect in a series of Bayesian meta-analyses. Meta-analytic estimates of the semantic interference effect first show that the effect is present throughout the reaction time distribution and that it increases throughout the distribution. Second, we find a correlation between a participant's mean semantic interference effect and the change in the effect in the tail of the reaction time distribution, which has been argued to reflect the involvement of selective inhibition in the naming task. Finally, we show with simulated data that this correlation emerges even when no inhibition is used to generate the data, which suggests that inhibition is not needed to explain this relationship. KW - Picture-word-interference task KW - Semantic interference effect KW - Selective KW - inhibition KW - Delta plot analyses KW - Individual differences Y1 - 2021 U6 - https://doi.org/10.3758/s13423-021-02016-6 SN - 1069-9384 SN - 1531-5320 VL - 29 IS - 2 SP - 635 EP - 647 PB - Springer CY - New York ER - TY - JOUR A1 - Aga-Barfknecht, Heja A1 - Soultoukis, George A. A1 - Stadion, Mandy A1 - Garcia-Carrizo, Francisco A1 - Jähnert, Markus A1 - Gottmann, Pascal A1 - Vogel, Heike A1 - Schulz, Tim Julius A1 - Schürmann, Annette T1 - Distinct adipogenic and fibrogenic differentiation capacities of mesenchymal stromal cells from pancreas and white adipose tissue JF - International journal of molecular sciences N2 - Pancreatic steatosis associates with beta-cell failure and may participate in the development of type-2-diabetes. Our previous studies have shown that diabetes-susceptible mice accumulate more adipocytes in the pancreas than diabetes-resistant mice. In addition, we have demonstrated that the co-culture of pancreatic islets and adipocytes affect insulin secretion. The aim of this current study was to elucidate if and to what extent pancreas-resident mesenchymal stromal cells (MSCs) with adipogenic progenitor potential differ from the corresponding stromal-type cells of the inguinal white adipose tissue (iWAT). miRNA (miRNome) and mRNA expression (transcriptome) analyses of MSCs isolated by flow cytometry of both tissues revealed 121 differentially expressed miRNAs and 1227 differentially expressed genes (DEGs). Target prediction analysis estimated 510 DEGs to be regulated by 58 differentially expressed miRNAs. Pathway analyses of DEGs and miRNA target genes showed unique transcriptional and miRNA signatures in pancreas (pMSCs) and iWAT MSCs (iwatMSCs), for instance fibrogenic and adipogenic differentiation, respectively. Accordingly, iwatMSCs revealed a higher adipogenic lineage commitment, whereas pMSCs showed an elevated fibrogenesis. As a low degree of adipogenesis was also observed in pMSCs of diabetes-susceptible mice, we conclude that the development of pancreatic steatosis has to be induced by other factors not related to cell-autonomous transcriptomic changes and miRNA-based signals. KW - MSCs KW - fatty pancreas KW - WAT KW - lineage commitment KW - transcriptomics KW - miRNAs Y1 - 2022 U6 - https://doi.org/10.3390/ijms23042108 SN - 1422-0067 VL - 23 IS - 4 PB - Molecular Diversity Preservation International CY - Basel ER - TY - JOUR A1 - Nguyen, Tam A1 - Kumar, Rohini A1 - Musolff, Andreas A1 - Lutz, Stefanie R. A1 - Sarrazin, Fanny A1 - Attinger, Sabine A1 - Fleckenstein, Jan H. T1 - Disparate Seasonal Nitrate Export From Nested Heterogeneous Subcatchments Revealed With StorAge Selection Functions JF - Water resources research N2 - Understanding catchment controls on catchment solute export is a prerequisite for water quality management. StorAge Selection (SAS) functions encapsulate essential information about catchment functioning in terms of discharge selection preference and solute export dynamics. However, they lack information on the spatial origin of solutes when applied at the catchment scale, thereby limiting our understanding of the internal (subcatchment) functioning. Here, we parameterized SAS functions in a spatially explicit way to understand the internal catchment responses and transport dynamics of reactive dissolved nitrate (N-NO3). The model was applied in a nested mesoscale catchment (457 km(2)), consisting of a mountainous partly forested, partly agricultural subcatchment, a middle-reach forested subcatchment, and a lowland agricultural subcatchment. The model captured flow and nitrate concentration dynamics not only at the catchment outlet but also at internal gauging stations. Results reveal disparate subsurface mixing dynamics and nitrate export among headwater and lowland subcatchments. The headwater subcatchment has high seasonal variation in subsurface mixing schemes and younger water in discharge, while the lowland subcatchment has less pronounced seasonality in subsurface mixing and much older water in discharge. Consequently, nitrate concentration in discharge from the headwater subcatchment shows strong seasonality, whereas that from the lowland subcatchment is stable in time. The temporally varying responses of headwater and lowland subcatchments alternate the dominant contribution to nitrate export in high and low-flow periods between subcatchments. Overall, our results demonstrate that the spatially explicit SAS modeling provides useful information about internal catchment functioning, helping to develop or evaluate spatial management practices. KW - catchment nitrate export KW - StorAge Selection function KW - travel time distribution KW - mesoscale heterogeneous catchment KW - subcatchment response Y1 - 2022 U6 - https://doi.org/10.1029/2021WR030797 SN - 0043-1397 SN - 1944-7973 VL - 58 IS - 3 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Serrano-Munoz, Itziar A1 - Fernández Serrano, Ricardo A1 - Saliwan-Neumann, Romeo A1 - Gonzalez-Doncel, Gaspar A1 - Bruno, Giovanni T1 - Dislocation substructures in pure aluminium after creep deformation as studied by electron backscatter diffraction JF - Journal of applied crystallography / International Union of Crystallography N2 - In the present work, electron backscatter diffraction was used to determine the microscopic dislocation structures generated during creep (with tests interrupted at the steady state) in pure 99.8% aluminium. This material was investigated at two different stress levels, corresponding to the power-law and power-law breakdown regimes. The results show that the formation of subgrain cellular structures occurs independently of the crystallographic orientation. However, the density of these cellular structures strongly depends on the grain crystallographic orientation with respect to the tensile axis direction, with (111) grains exhibiting the highest densities at both stress levels. It is proposed that this behaviour is due to the influence of intergranular stresses, which is different in (111) and (001) grains. KW - creep KW - pure aluminium KW - electron backscatter diffraction (EBSD) KW - cellular KW - structures KW - power law and power-law breakdown Y1 - 2022 U6 - https://doi.org/10.1107/S1600576722005209 SN - 1600-5767 VL - 55 SP - 860 EP - 869 PB - Munksgaard CY - Copenhagen ER - TY - JOUR A1 - Neuschäfer-Rube, Frank A1 - Pathe-Neuschäfer-Rube, Andrea A1 - Püschel, Gerhard Paul T1 - Discrimination of the activity of low-affinity wild-type and high-affinity mutant recombinant BoNT/B by a SIMA cell-based reporter release assay JF - Toxins N2 - Botulinum neurotoxin (BoNT) is used for the treatment of a number of ailments. The activity of the toxin that is isolated from bacterial cultures is frequently tested in the mouse lethality assay. Apart from the ethical concerns inherent to this assay, species-specific differences in the affinity for different BoNT serotypes give rise to activity results that differ from the activity in humans. Thus, BoNT/B is more active in mice than in humans. The current study shows that the stimulus-dependent release of a luciferase from a differentiated human neuroblastoma–based reporter cell line (SIMA-hPOMC1-26-Gluc) was inhibited by clostridial and recombinant BoNT/A to the same extent, whereas both clostridial and recombinant BoNT/B inhibited the release to a lesser extent and only at much higher concentrations, reflecting the low activity of BoNT/B in humans. By contrast, the genetically modified BoNT/B-MY, which has increased affinity for human synaptotagmin, and the BoNT/B protein receptor inhibited luciferase release effectively and with an EC50 comparable to recombinant BoNT/A. This was due to an enhanced uptake into the reporter cells of BoNT/B-MY in comparison to the recombinant wild-type toxin. Thus, the SIMA-hPOMC1-26-Gluc cell assay is a versatile tool to determine the activity of different BoNT serotypes providing human-relevant dose-response data. KW - cell-based assay KW - genetically modified BoNT KW - BoNT/B uptake Y1 - 2022 U6 - https://doi.org/10.3390/toxins14010065 SN - 2072-6651 VL - 14 SP - 1 EP - 11 PB - MDPI CY - Basel, Schweiz ET - 1 ER - TY - JOUR A1 - Sachse, Manuel A1 - Kappel, David A1 - Tirsch, Daniela A1 - Otto, Katharina A. T1 - Discrete element modeling of aeolian-like morphologies on comet 67P/Churyumov-Gerasimenko JF - Astronomy and astrophysics : an international weekly journal N2 - Context. Even after the Rosetta mission, some of the mechanical parameters of comet 67P/Churyumov-Gerasimenko's surface material are still not well constrained. They are needed to improve our understanding of cometary activity or for planning sample return procedures. Aims. We discuss the physical process dominating the formation of aeolian-like surface features in the form of moats and wind taillike bedforms around obstacles and investigate the mechanical and geometrical parameters involved. Methods. By applying the discrete element method (DEM) in a low-gravity environment, we numerically simulated the dynamics of the surface layer particles and the particle stream involved in the formation of aeolian-like morphological features. The material is composed of polydisperse spherical particles that consist of a mixture of dust and water ice, with interparticle forces given by the Hertz contact model, cohesion, friction, and rolling friction. We determined a working set of parameters that enables simulations to be reasonably realistic and investigated morphological changes when modifying these parameters. Results. The aeolian-like surface features are reasonably well reproduced using model materials with a tensile strength on the order of 0.1-1 Pa. Stronger materials and obstacles with round shapes impede the formation of a moat and a wind tail. The integrated dust flux required for the formation of moats and wind tails is on the order of 100 kg m(-2), which, based on the timescale of morphological changes inferred from Rosetta images, translates to a near-surface particle density on the order of 10(-6)-10(-4) kg m(-3). Conclusions. DEM modeling of the aeolian-like surface features reveals complex formation mechanisms that involve both deposition of ejected material and surface erosion. More numerical work and additional in situ measurements or sample return missions are needed to better investigate mechanical parameters of cometary surface material and to understand the mechanics of cometary activity. KW - comets: general KW - comets: individual: 67P/Churyumov-Gerasimenko KW - methods: numerical Y1 - 2022 U6 - https://doi.org/10.1051/0004-6361/202141296 SN - 0004-6361 SN - 1432-0746 VL - 662 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Kupfer, Thomas A1 - Bauer, Evan B. A1 - van Roestel, Jan A1 - Bellm, Eric C. A1 - Bildsten, Lars A1 - Fuller, Jim A1 - Prince, Thomas A. A1 - Heber, Ulrich A1 - Geier, Stephan A1 - Green, Matthew J. A1 - Kulkarni, Shrinivas R. A1 - Bloemen, Steven A1 - Laher, Russ R. A1 - Rusholme, Ben A1 - Schneider, David T1 - Discovery of a Double-detonation Thermonuclear Supernova Progenitor JF - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters N2 - We present the discovery of a new double-detonation progenitor system consisting of a hot subdwarf B (sdB) binary with a white dwarf companion with a P (orb) = 76.34179(2) minutes orbital period. Spectroscopic observations are consistent with an sdB star during helium core burning residing on the extreme horizontal branch. Chimera light curves are dominated by ellipsoidal deformation of the sdB star and a weak eclipse of the companion white dwarf. Combining spectroscopic and light curve fits, we find a low-mass sdB star, M (sdB) = 0.383 +/- 0.028 M (circle dot) with a massive white dwarf companion, M (WD) = 0.725 +/- 0.026 M (circle dot). From the eclipses we find a blackbody temperature for the white dwarf of 26,800 K resulting in a cooling age of approximate to 25 Myr whereas our MESA model predicts an sdB age of approximate to 170 Myr. We conclude that the sdB formed first through stable mass transfer followed by a common envelope which led to the formation of the white dwarf companion approximate to 25 Myr ago. Using the MESA stellar evolutionary code we find that the sdB star will start mass transfer in approximate to 6 Myr and in approximate to 60 Myr the white dwarf will reach a total mass of 0.92 M (circle dot) with a thick helium layer of 0.17 M (circle dot). This will lead to a detonation that will likely destroy the white dwarf in a peculiar thermonuclear supernova. PTF1 J2238+7430 is only the second confirmed candidate for a double-detonation thermonuclear supernova. Using both systems we estimate that at least approximate to 1% of white dwarf thermonuclear supernovae originate from sdB+WD binaries with thick helium layers, consistent with the small number of observed peculiar thermonuclear explosions. Y1 - 2022 U6 - https://doi.org/10.3847/2041-8213/ac48f1 SN - 2041-8205 SN - 2041-8213 VL - 925 IS - 2 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Pelisoli, Ingrid A1 - Dorsch, Matti A1 - Heber, Ulrich A1 - Gänsicke, Boris A1 - Geier, Stephan A1 - Kupfer, Thomas A1 - Nemeth, Peter A1 - Scaringi, Simone A1 - Schaffenroth, Veronika T1 - Discovery and analysis of three magnetic hot subdwarf stars BT - evidence for merger-induced magnetic fields JF - Monthly notices of the Royal Astronomical Society N2 - Magnetic fields can play an important role in stellar evolution. Among white dwarfs, the most common stellar remnant, the fraction of magnetic systems is more than 20 per cent. The origin of magnetic fields in white dwarfs, which show strengths ranging from 40 kG to hundreds of MG, is still a topic of debate. In contrast, only one magnetic hot subdwarf star has been identified out of thousands of known systems. Hot subdwarfs are formed from binary interaction, a process often associated with the generation of magnetic fields, and will evolve to become white dwarfs, which makes the lack of detected magnetic hot subdwarfs a puzzling phenomenon. Here we report the discovery of three new magnetic hot subdwarfs with field strengths in the range 300-500 kG. Like the only previously known system, they are all helium-rich O-type stars (He-sdOs). We analysed multiple archival spectra of the three systems and derived their stellar properties. We find that they all lack radial velocity variability, suggesting formation via a merger channel. However, we derive higher than typical hydrogen abundances for their spectral type, which are in disagreement with current model predictions. Our findings suggest a lower limit to the magnetic fraction of hot subdwarfs of 0.147(+0.143)(-0.047) per cent, and provide evidence for merger-induced magnetic fields which could explain white dwarfs with field strengths of 50-150 MG, assuming magnetic flux conservation. KW - stars: magnetic field KW - subdwarfs Y1 - 2022 U6 - https://doi.org/10.1093/mnras/stac1069 SN - 0035-8711 SN - 1365-2966 VL - 515 IS - 2 SP - 2496 EP - 2510 PB - Oxford University Press CY - Oxford ER - TY - JOUR A1 - Biermann, Robin Tim A1 - Bach, Linh T. A1 - Kläring, Hans-Peter A1 - Baldermann, Susanne A1 - Börnke, Frederik A1 - Schwarz, Dietmar T1 - Discovering tolerance-A computational approach to assess abiotic stress tolerance in tomato under greenhouse conditions JF - Frontiers in sustainable food systems N2 - Modern plant cultivars often possess superior growth characteristics, but within a limited range of environmental conditions. Due to climate change, crops will be exposed to distressing abiotic conditions more often in the future, out of which heat stress is used as example for this study. To support identification of tolerant germplasm and advance screening techniques by a novel multivariate evaluation method, a diversity panel of 14 tomato genotypes, comprising Mediterranean landraces of Solanum lycopersicum, the cultivar "Moneymaker" and Solanum pennellii LA0716, which served as internal references, was assessed toward their tolerance against long-term heat stress. After 5 weeks of growth, young tomato plants were exposed to either control (22/18 degrees C) or heat stress (35/25 degrees C) conditions for 2 weeks. Within this period, water consumption, leaf angles and leaf color were determined. Additionally, gas exchange and leaf temperature were investigated. Finally, biomass traits were recorded. The resulting multivariate dataset on phenotypic plasticity was evaluated to test the hypothesis, that more tolerant genotypes have less affected phenotypes upon stress adaptation. For this, a cluster-analysis-based approach was developed that involved a principal component analysis (PCA), dimension reduction and determination of Euclidean distances. These distances served as measure for the phenotypic plasticity upon heat stress. Statistical evaluation allowed the identification and classification of homogeneous groups consisting each of four putative more or less heat stress tolerant genotypes. The resulting classification of the internal references as "tolerant" highlights the applicability of our proposed tolerance assessment model. PCA factor analysis on principal components 1-3 which covered 76.7% of variance within the phenotypic data, suggested that some laborious measure such as the gas exchange might be replaced with the determination of leaf temperature in larger heat stress screenings. Hence, the overall advantage of the presented method is rooted in its suitability of both, planning and executing screenings for abiotic stress tolerance using multivariate phenotypic data to overcome the challenge of identifying abiotic stress tolerant plants from existing germplasms and promote sustainable agriculture for the future. KW - abiotic stress KW - breeding KW - heat stress KW - phenotyping KW - Solanum KW - lycopersicum KW - screening KW - stress tolerance Y1 - 2022 U6 - https://doi.org/10.3389/fsufs.2022.878013 SN - 2571-581X VL - 6 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Puebla Antunes, Cecilia A1 - Felser, Claudia T1 - Discourse Prominence and Antecedent MisRetrieval during Native and Non-Native Pronoun Resolution JF - Discours : revue de linguistique, psycholinguistique et informatique N2 - Previous studies on non-native (L2) anaphor resolution suggest that L2 comprehenders are guided more strongly by discourse-level cues compared to native (L1) comprehenders. Here we examine whether and how a grammatically inappropriate antecedent’s discourse status affects the likelihood of it being considered during L1 and L2 pronoun resolution. We used an interference paradigm to examine how the extrasentential discourse impacts the resolution of German object pronouns. In an eye-tracking-during-reading experiment we examined whether an elaborated local antecedent ruled out by binding Condition B would be mis-retrieved during pronoun resolution, and whether initially introducing this antecedent as the discourse topic would affect the chances of it being mis-retrieved. While both participant groups rejected the inappropriate antecedent in an offline questionnaire irrespective of its discourse prominence, their real-time processing patterns differed. L1 speakers initially mis-retrieved the inappropriate antecedent regardless of its contextual prominence. L1 Russian/L2 German speakers, in contrast, were affected by the antecedent’s discourse status, considering it only when it was discourse-new but not when it had previously been introduced as the discourse topic. Our findings show that L2 comprehenders are highly sensitive to discourse dynamics such as topic shifts, supporting the claim that discourse-level cues are more strongly weighted during L2 compared to L1 processing. KW - pronoun resolution KW - non-native sentence processing KW - discourse KW - prominence KW - interference KW - German KW - eye-movement monitoring Y1 - 2022 U6 - https://doi.org/10.4000/discours.11720 SN - 1963-1723 IS - 29 PB - Université de Paris-Sorbonne, Maion Recherche CY - Paris ER - TY - JOUR A1 - Skopeteas, Stavros A1 - Verhoeven, Elisabeth A1 - Fanselow, Gisbert T1 - Discontinuous noun phrases in Yucatec Maya JF - Journal of linguistics : JL / publ. for the Linguistics Association of Great Britain N2 - Languages differ in whether or not they allow discontinuous noun phrases. If they do, they further vary in the ways the nominal projections interact with the available syntactic operations. Yucatec Maya has two left-peripheral configurations that differ syntactically: a preverbal position for foci or wh-elements that is filled in by movement, and the possibility to adjoin topics at the highest clausal layer. These two structural options are reflected in different ways of the formation of discontinuous patterns. Subextraction from nominal projections to the focus position yielding discontinuous NPs is possible, but subject to several restrictions. It observes conditions on extraction domains, and does not apply to the left branch of nominal structures. The topic position also appears to license discontinuity, typically involving a non-referential nominal expression as the topic and quantifiers/adjectives that form an elliptical nominal projection within the clause proper. Such constructions can involve several morphological and syntactic mismatches between their parts that are excluded for continuous noun phrases, and they are not sensitive to syntactic island restrictions. Thus, in a strict sense, discontinuities involving the topic position are only apparent, because the construction involves two independent nominal projections that are semantically linked. KW - discontinuous noun phrases KW - focus movement KW - left dislocation KW - possessor KW - extraction KW - split topicalization Y1 - 2022 U6 - https://doi.org/10.1017/S0022226720000419 SN - 0022-2267 SN - 1469-7742 VL - 58 IS - 3 SP - 609 EP - 648 PB - Cambridge University Press CY - New York ER - TY - JOUR A1 - Brück, Christian A1 - Knauer, Thorsten A1 - Schwering, Anja T1 - Disclosure of value-based performance measures BT - evidence from German listed firms JF - Accounting and business research N2 - We examine the determinants of the disclosure of value-based (VB) performance measures in Germany. We argue that firms are more likely to disclose VB performance measures when information asymmetry is greater, as greater information asymmetry means firms have a greater need to credibly signal a shareholder value orientation. Using a hand-collected dataset of German listed firms covering 1,528 firm-years from 2004 to 2011, we demonstrate that firms are more likely to disclose a VB performance measure if the free float is larger than the blocking minority and also, when firms are large, if they have high foreign sales to total sales ratios and are not cross-listed internationally. Our results indicate that German firms use VB performance measures to improve investor communication and to substantiate their shareholder value orientation. Our results should be interpreted against a background of increased shareholder value orientation and sophisticated cost accounting in German firms. KW - Value-based performance measures KW - shareholder value KW - disclosure KW - investor communication Y1 - 2022 U6 - https://doi.org/10.1080/00014788.2022.2062585 SN - 0001-4788 SN - 2159-4260 VL - 53 IS - 6 SP - 671 EP - 698 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Voroshnin, Vladimir A1 - Tarasov, Artem V. A1 - Bokai, Kirill A. A1 - Chikina, Alla A1 - Senkovskiy, Boris V. A1 - Ehlen, Niels A1 - Usachov, Dmitry Yu. A1 - Gruneis, Alexander A1 - Krivenkov, Maxim A1 - Sanchez-Barriga, Jaime A1 - Fedorov, Alexander T1 - Direct spectroscopic evidence of magnetic proximity effect in MoS2 monolayer on graphene/Co JF - ACS nano N2 - A magnetic field modifies optical properties and provides valley splitting in a molybdenum disulfide (MoS2) monolayer. Here we demonstrate a scalable approach to the epitaxial synthesis of MoS2 monolayer on a magnetic graphene/Co system. Using spin- and angle-resolved photoemission spectroscopy we observe a magnetic proximity effect that causes a 20 meV spin-splitting at the (Gamma) over bar point and canting of spins at the (K) over bar point in the valence band toward the in-plane direction of cobalt magnetization. Our density functional theory calculations reveal that the in-plane spin component at (K) over bar is localized on Co atoms in the valence band, while in the conduction band it is localized on the MoS2 layer. The calculations also predict a 16 meV spin-splitting at the (Gamma) over bar point and 8 meV (K) over bar-(K) over bar' valley asymmetry for an out-of-plane magnetization. These findings suggest control over optical transitions in MoS2 via Co magnetization. Our estimations show that the magnetic proximity effect is equivalent to the action of the magnetic field as large as 100 T. KW - magnetic proximity effect KW - MoS2 KW - monolayer KW - graphene KW - spin-resolved KW - ARPES Y1 - 2022 U6 - https://doi.org/10.1021/acsnano.1c10391 SN - 1936-0851 SN - 1936-086X VL - 16 IS - 5 SP - 7448 EP - 7456 PB - American Chemical Society CY - Washington ER - TY - JOUR A1 - Wittenbecher, Clemens A1 - Cuadrat, Rafael A1 - Johnston, Luke A1 - Eichelmann, Fabian A1 - Jäger, Susanne A1 - Kuxhaus, Olga A1 - Prada, Marcela A1 - Del Greco, Fabiola M. A1 - Hicks, Andrew A. A1 - Hoffman, Per A1 - Krumsiek, Jan A1 - Hu, Frank B. A1 - Schulze, Matthias B. T1 - Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology JF - Nature communications N2 - Metabolic alterations precede cardiometabolic disease onset. Here we present ceramide- and dihydroceramide-profiling data from a nested case-cohort (type 2 diabetes [T2D, n = 775]; cardiovascular disease [CVD, n = 551]; random subcohort [n = 1137]) in the prospective EPIC-Potsdam study. We apply the novel NetCoupler-algorithm to link a data-driven (dihydro)ceramide network to T2D and CVD risk. Controlling for confounding by other (dihydro)ceramides, ceramides C18:0 and C22:0 and dihydroceramides C20:0 and C22:2 are associated with higher and ceramide C20:0 and dihydroceramide C26:1 with lower T2D risk. Ceramide C16:0 and dihydroceramide C22:2 are associated with higher CVD risk. Genome-wide association studies and Mendelian randomization analyses support a role of ceramide C22:0 in T2D etiology. Our results also suggest that (dh)ceramides partly mediate the putative adverse effect of high red meat consumption and benefits of coffee consumption on T2D risk. Thus, (dihydro)ceramides may play a critical role in linking genetic predisposition and dietary habits to cardiometabolic disease risk. Y1 - 2022 U6 - https://doi.org/10.1038/s41467-022-28496-1 SN - 2041-1723 VL - 13 PB - Nature Research CY - Berlin ER - TY - JOUR A1 - Lewkowicz, Daniel A1 - Wohlbrandt, Attila M. A1 - Böttinger, Erwin T1 - Digital therapeutic care apps with decision-support interventions for people with low back pain in Germany BT - Cost-effectiveness analysis JF - JMIR mhealth and uhealth N2 - Background: Digital therapeutic care apps provide a new effective and scalable approach for people with nonspecific low back pain (LBP). Digital therapeutic care apps are also driven by personalized decision-support interventions that support the user in self-managing LBP, and may induce prolonged behavior change to reduce the frequency and intensity of pain episodes. However, these therapeutic apps are associated with high attrition rates, and the initial prescription cost is higher than that of face-to-face physiotherapy. In Germany, digital therapeutic care apps are now being reimbursed by statutory health insurance; however, price targets and cost-driving factors for the formation of the reimbursement rate remain unexplored. Objective: The aim of this study was to evaluate the cost-effectiveness of a digital therapeutic care app compared to treatment as usual (TAU) in Germany. We further aimed to explore under which circumstances the reimbursement rate could be modified to consider value-based pricing. Methods: We developed a state-transition Markov model based on a best-practice analysis of prior LBP-related decision-analytic models, and evaluated the cost utility of a digital therapeutic care app compared to TAU in Germany. Based on a 3-year time horizon, we simulated the incremental cost and quality-adjusted life years (QALYs) for people with nonacute LBP from the societal perspective. In the deterministic sensitivity and scenario analyses, we focused on diverging attrition rates and app cost to assess our model's robustness and conditions for changing the reimbursement rate. All costs are reported in Euro (euro1=US $1.12). Results: Our base case results indicated that the digital therapeutic care strategy led to an incremental cost of euro121.59, but also generated 0.0221 additional QALYs compared to the TAU strategy, with an estimated incremental cost-effectiveness ratio (ICER) of euro5486 per QALY. The sensitivity analysis revealed that the reimbursement rate and the capability of digital therapeutic care to prevent reoccurring LBP episodes have a significant impact on the ICER. At the same time, the other parameters remained unaffected and thus supported the robustness of our model. In the scenario analysis, the different model time horizons and attrition rates strongly influenced the economic outcome. Reducing the cost of the app to euro99 per 3 months or decreasing the app's attrition rate resulted in digital therapeutic care being significantly less costly with more generated QALYs, and is thus considered to be the dominant strategy over TAU. Conclusions: The current reimbursement rate for a digital therapeutic care app in the statutory health insurance can be considered a cost-effective measure compared to TAU. The app's attrition rate and effect on the patient's prolonged behavior change essentially influence the settlement of an appropriate reimbursement rate. Future value-based pricing targets should focus on additional outcome parameters besides pain intensity and functional disability by including attrition rates and the app's long-term effect on quality of life. KW - cost-utility analysis KW - low back pain KW - back pain KW - cost-effectiveness KW - Markov model KW - digital therapy KW - digital health app KW - mHealth KW - orthopedic; KW - eHealth KW - mobile health KW - digital health KW - pain management KW - health apps Y1 - 2022 U6 - https://doi.org/10.2196/35042 SN - 2291-5222 VL - 10 IS - 2 PB - JMIR Publications CY - Toronto ER - TY - JOUR A1 - van Marle, Allard Jan A1 - Bohdan, Artem A1 - Morris, Paul J. A1 - Pohl, Martin A1 - Marcowith, Alexandre T1 - Diffusive shock acceleration at oblique high mach number shocks JF - The astrophysical journal : an international review of spectroscopy and astronomical physics N2 - The current paradigm of cosmic-ray (CR) origin states that the greater part of galactic CRs is produced by supernova remnants. The interaction of supernova ejecta with the interstellar medium after a supernova's explosions results in shocks responsible for CR acceleration via diffusive shock acceleration (DSA). We use particle-in-cell (PIC) simulations and a combined PIC-magnetohydrodynamic (PIC-MHD) technique to investigate whether DSA can occur in oblique high Mach number shocks. Using the PIC method, we follow the formation of the shock and determine the fraction of the particles that gets involved in DSA. With this result, we use PIC-MHD simulations to model the large-scale structure of the plasma and the magnetic field surrounding the shock and find out whether or not the reflected particles can generate upstream turbulence and trigger DSA. We find that the feasibility of this process in oblique shocks depends strongly on the Alfvenic Mach number, and the DSA process is more likely to be triggered at high Mach number shocks. Y1 - 2022 U6 - https://doi.org/10.3847/1538-4357/ac5962 SN - 1538-4357 VL - 929 IS - 1 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Mani, Deepak A1 - Kupsch, Andreas A1 - Müller, Bernd R. A1 - Bruno, Giovanni T1 - Diffraction Enhanced Imaging Analysis with Pseudo-Voigt Fit Function JF - Journal of imaging : open access journal N2 - Diffraction enhanced imaging (DEI) is an advanced digital radiographic imaging technique employing the refraction of X-rays to contrast internal interfaces. This study aims to qualitatively and quantitatively evaluate images acquired using this technique and to assess how different fitting functions to the typical rocking curves (RCs) influence the quality of the images. RCs are obtained for every image pixel. This allows the separate determination of the absorption and the refraction properties of the material in a position-sensitive manner. Comparison of various types of fitting functions reveals that the Pseudo-Voigt (PsdV) function is best suited to fit typical RCs. A robust algorithm was developed in the Python programming language, which reliably extracts the physically meaningful information from each pixel of the image. We demonstrate the potential of the algorithm with two specimens: a silicone gel specimen that has well-defined interfaces, and an additively manufactured polycarbonate specimen. KW - diffraction enhanced imaging KW - analyzer-based imaging KW - X-ray refraction; KW - non-destructive evaluation KW - Pseudo-Voigt fit function KW - Python Y1 - 2022 U6 - https://doi.org/10.3390/jimaging8080206 SN - 2313-433X VL - 8 IS - 8 PB - MDPI CY - Basel ER - TY - JOUR A1 - Lau, Skadi A1 - Gossen, Manfred A1 - Lendlein, Andreas A1 - Jung, Friedrich T1 - Differential sensitivity of assays for determining vein endothelial cell senescence JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - In vivo endothelialization of polymer-based cardiovascular implant materials is a promising strategy to reduce the risk of platelet adherence and the subsequent thrombus formation and implant failure. However, endothelial cells from elderly patients are likely to exhibit a senescent phenotype that may counteract endothelialization. The senescence status of cells should therefore be investigated prior to implantation of devices designed to be integrated in the blood vessel wall. Here, human umbilical vein endothelial cells (HUVEC) were cultivated up to passage (P) 4, 10 and 26/27 to determine the population doubling time and the senescence status by four different methods. Determination of the senescence-associated beta-galactosidase activity (SA-beta-Gal) was carried out by colorimetric staining and microscopy (i), as well as by photometric quantification (ii), and the expression of senescence-associated nuclear proteins p16 and p21 as well as the proliferation marker Ki67 was assessed by immunostaining (iii), and by flow cytometry (iv). The population doubling time of P27-cells was remarkably greater (103 +/- 65 h) compared to P4-cells (24 +/- 3 h) and P10-cell (37 +/- 15 h). Among the four different methods tested, the photometric SA-beta-Gal activity assay and the flow cytometric determination of p16 and Ki67 were most effective in discriminating P27-cells from P4- and P10-cells. These methods combined with functional endothelial cell analyses might aid predictions on the performance of implant endothelialization in vivo. KW - Ageing KW - population doubling time KW - senescence-associated KW - beta-galactosidase KW - cell cycle inhibitors KW - p16 KW - p21 KW - Ki67 Y1 - 2022 U6 - https://doi.org/10.3233/CH-211294 SN - 1386-0291 SN - 1875-8622 VL - 81 IS - 3 SP - 191 EP - 203 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Heinze, Peter Eric A1 - Weck, Florian A1 - Hahn, Daniela A1 - Kühne, Franziska T1 - Differences in psychotherapy preferences between psychotherapy trainees and laypeople JF - Psychotherapy research : the official journal of the Society for Psychotherapy Research N2 - Objective: Despite increasing research on psychotherapy preferences, the preferences of psychotherapy trainees are largely unknown. Moreover, differences in preferences between trainees and their patients could (a) hinder symptom improvement and therapy success for patients and (b) represent significant obstacles in the early career and development of future therapists. Method: We compared the preferences of n = 466 psychotherapy trainees to those of n = 969 laypersons using the Cooper-Norcross Inventory of Preferences. Moreover, we compared preferences between trainees in cognitive-behavioural therapy (CBT) and psychodynamic trainees. Results: We found significant differences between both samples in 13 of 18 items, and three of four subscales. Psychotherapy trainees preferred less therapist directiveness (d = 0.58), more emotional intensity (d = 0.74), as well as more focused challenge (d = 0.35) than laypeople. CBT trainees preferred more therapist directiveness (d = 2.00), less emotional intensity (d = 0.51), more present orientation (d = 0.76) and more focused challenge (d = 0.33) than trainees in psychodynamic/psychoanalytic therapy. Conclusion: Overall, the results underline the importance of implementing preference assessment and discussion during psychotherapy training. Moreover, therapists of different orientations seem to cover a large range of preferences for patients, in order to choose the right fit. KW - psychotherapy process KW - psychotherapy training KW - activity preference; KW - C-NIP KW - assessment Y1 - 2022 U6 - https://doi.org/10.1080/10503307.2022.2098076 SN - 1050-3307 SN - 1468-4381 VL - 33 IS - 3 SP - 374 EP - 386 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Michaelis, Vivien A1 - Aengenheister, Leonie A1 - Tuchtenhagen, Max A1 - Rinklebe, Jörg A1 - Ebert, Franziska A1 - Schwerdtle, Tanja A1 - Buerki-Thurnherr, Tina A1 - Bornhorst, Julia T1 - Differences and interactions in placental manganese and iron transfer across an in vitro model of human villous trophoblasts JF - International journal of molecular sciences N2 - Manganese (Mn) as well as iron (Fe) are essential trace elements (TE) important for the maintenance of physiological functions including fetal development. However, in the case of Mn, evidence suggests that excess levels of intrauterine Mn are associated with adverse pregnancy outcomes. Although Mn is known to cross the placenta, the fundamentals of Mn transfer kinetics and mechanisms are largely unknown. Moreover, exposure to combinations of TEs should be considered in mechanistic transfer studies, in particular for TEs expected to share similar transfer pathways. Here, we performed a mechanistic in vitro study on the placental transfer of Mn across a BeWo b30 trophoblast layer. Our data revealed distinct differences in the placental transfer of Mn and Fe. While placental permeability to Fe showed a clear inverse dose-dependency, Mn transfer was largely independent of the applied doses. Concurrent exposure of Mn and Fe revealed transfer interactions of Fe and Mn, indicating that they share common transfer mechanisms. In general, mRNA and protein expression of discussed transporters like DMT1, TfR, or FPN were only marginally altered in BeWo cells despite the different exposure scenarios highlighting that Mn transfer across the trophoblast layer likely involves a combination of active and passive transport processes. KW - manganese KW - iron KW - placental transfer KW - TE interactions KW - BeWo b30 KW - trophoblasts Y1 - 2022 U6 - https://doi.org/10.3390/ijms23063296 SN - 1422-0067 VL - 23 IS - 6 PB - MDPI CY - Basel ER - TY - JOUR A1 - Kroke, Anja A1 - Schmidt, Annemarie A1 - Amini, Anna M. A1 - Kalotai, Nicole A1 - Lehmann, Andreas A1 - Haardt, Julia A1 - Bauer, Jürgen M. A1 - Bischoff-Ferrari, Heike A. A1 - Boeing, Heiner A1 - Egert, Sarah A1 - Ellinger, Sabine A1 - Kühn, Tilman A1 - Louis, Sandrine A1 - Lorkowski, Stefan A1 - Nimptsch, Katharina A1 - Remer, Thomas A1 - Schulze, Matthias B. A1 - Siener, Roswitha A1 - Stangl, Gabriele A1 - Volkert, Dorothee A1 - Zittermann, Armin A1 - Buyken, Anette E. A1 - Watzl, Bernhard A1 - Schwingshackl, Lukas T1 - Dietary protein intake and health-related outcomes: a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society JF - European journal of nutrition N2 - Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake. KW - Evidence-based guideline KW - Protein intake KW - Method KW - Prevention KW - Nutrition-related diseases Y1 - 2022 U6 - https://doi.org/10.1007/s00394-021-02789-5 SN - 1436-6207 SN - 1436-6215 VL - 61 IS - 4 SP - 2091 EP - 2101 PB - Springer Nature CY - Heidelberg ER - TY - JOUR A1 - Koelman, Liselot A. A1 - Huybrechts, Inge A1 - Biesbroek, Sander A1 - van 't Veer, Pieter A1 - Schulze, Matthias Bernd A1 - Aleksandrova, Krasimira T1 - Dietary choices impact on greenhouse gas emissions BT - determinants and correlates in a sample of adults from Eastern Germany JF - Sustainability / Multidisciplinary Digital Publishing Institute (MDPI) N2 - The present study estimated diet-related greenhouse gas emissions (GHGE) and land use (LU) in a sample of adults, examined main dietary contributors of GHGE, and evaluated socio demographic, lifestyle, and wellbeing factors as potential determinants of high environmental impact. A cross-sectional design based on data collected from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (2010-2012) was used. Usual diet was assessed using food frequency questionnaires. Diet-related GHGE and LU were calculated using a European-average lifecycle analyses-food-item database (SHARP-ID). Information on potential determinants were collected using self-administered questionnaires. Men (n = 404) and women (n = 401) at an average age of 66.0 +/- 8.4 years were included. Dietary-related energy-adjusted GHGE in men was 6.6 +/- 0.9 and in women was 7.0 +/- 1.1 kg CO2 eq per 2000 kcal. LU in men was 7.8 +/- 1.2 and in women was 7.7 +/- 1.2 m(2)/year per 2000 kcal. Food groups contributing to most GHGE included dairy, meat and non-alcoholic beverages. Among women, being single, having a job, being a smoker and having higher BMI were characteristics associated with higher GHGE, whereas for men these included being married, longer sleeping duration and higher BMI. Further studies are warranted to provide insights into population-specific determinants of sustainable dietary choices. KW - dietary choices KW - environmental impact KW - greenhouse gas emissions KW - land use KW - determinants Y1 - 2022 U6 - https://doi.org/10.3390/su14073854 SN - 2071-1050 VL - 14 IS - 7 PB - MDPI CY - Basel ER - TY - JOUR A1 - Menzel, Juliane A1 - Longree, Alessa A1 - Abraham, Klaus A1 - Schulze, Matthias Bernd A1 - Weikert, Cornelia T1 - Dietary and plasma phospholipid profiles in vegans and omnivores-results from the RBVD study JF - Nutrients N2 - Over the last few years, the vegan diet has become increasingly popular in Germany. It has been proposed that this diet is generally lower in fat, but less is known about the impact on fatty acid (FA) profiles. Therefore, the cross-sectional "Risks and Benefits of a Vegan Diet" (RBVD) study (n = 72) was used to investigate dietary FA intake as well as plasma phospholipid FA in vegans (n = 36) compared to omnivores (n = 36). Vegans had a significantly lower dietary intake of total fat (median 86 g/day, IQR 64-111) in comparison to omnivores (median 104 g/day, IQR 88-143, p = 0.004). Further, vegans had a lower intake of saturated fatty acids (SFA) (p < 0.0001) and monounsaturated fatty acids (MUFA) (p = 0.001) compared to omnivores. Vegans had a higher intake in total polyunsaturated fatty acids (PUFA), omega-3 and omega-6 PUFA compared to omnivores, but without statistical significance after Bonferroni correction. According to plasma phospholipid profiles, relatively lower proportions of SFA (p < 0.0001), total trans fatty acids (TFA) (p = 0.0004) and omega-3-FA (p < 0.0001), but higher proportions of omega-6-FA (p < 0.0001) were observed in vegans. With the exception of omega-3 PUFA, a vegan diet is associated with a more favorable dietary fat intake and more favorable plasma FA profiles and therefore may reduce cardiovascular risk. KW - SFA KW - TFA KW - MUFA KW - PUFA KW - n-3 fatty acid KW - n-6 fatty acid KW - fatty acids KW - vegan diet Y1 - 2022 U6 - https://doi.org/10.3390/nu14142900 SN - 2072-6643 VL - 14 IS - 14 PB - MDPI CY - Basel ER - TY - JOUR A1 - Scholz, Carolin A1 - Voigt, Christian C. T1 - Diet analysis of bats killed at wind turbines suggests large-scale losses of trophic interactions JF - Conservation science and practice N2 - Agricultural practice has led to landscape simplification and biodiversity decline, yet recently, energy-producing infrastructures, such as wind turbines, have been added to these simplified agroecosystems, turning them into multi-functional energy-agroecosystems. Here, we studied the trophic interactions of bats killed at wind turbines using a DNA metabarcoding approach to shed light on how turbine-related bat fatalities may possibly affect local habitats. Specifically, we identified insect DNA in the stomachs of common noctule bats (Nyctalus noctula) killed by wind turbines in Germany to infer in which habitats these bats hunted. Common noctule bats consumed a wide variety of insects from different habitats, ranging from aquatic to terrestrial ecosystems (e.g., wetlands, farmland, forests, and grasslands). Agricultural and silvicultural pest insects made up about 20% of insect species consumed by the studied bats. Our study suggests that the potential damage of wind energy production goes beyond the loss of bats and the decline of bat populations. Bat fatalities at wind turbines may lead to the loss of trophic interactions and ecosystem services provided by bats, which may add to the functional simplification and impaired crop production, respectively, in multi-functional ecosystems. KW - bat fatalities KW - biodiversity decline KW - food web KW - green-green dilemma KW - renewable energy KW - wind energy production KW - wind energy-biodiversity conflict Y1 - 2022 U6 - https://doi.org/10.1111/csp2.12744 SN - 2578-4854 VL - 4 IS - 7 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Caliendo, Marco A1 - Wittbrodt, Linda T1 - Did the minimum wage reduce the gender wage gap in Germany? JF - Labour economics N2 - In many countries, women are over-represented among low-wage employees, which is why a wage floor could benefit them particularly. Following this notion, we analyse the impact of the German minimum wage introduction in 2015 on the gender wage gap. Germany poses an interesting case study in this context, since it has a rather high gender wage gap and set the minimum wage at a relatively high level, affecting more than four million employees. Based on individual data from the Structure of Earnings Survey, containing information for over one million employees working in 60,000 firms, we use a difference-in-difference framework that exploits regional differences in the bite of the minimum wage. We find a significant negative effect of the minimum wage on the regional gender wage gap. Between 2014 and 2018, the gap at the 10th percentile of the wage distribution was reduced by 4.6 percentage points (or 32%) in regions that were strongly affected by the minimum wage compared to less affected regions. For the gap at the 25th percentile, the effect still amounted to 18%, while for the mean it was smaller (11%) and not particularly robust. We thus find that the minimum wage can indeed reduce gender wage disparities. While the effect is highest for the low-paid, it also reaches up into higher parts of the wage distribution. KW - minimum wage KW - gender wage gap KW - regional bite Y1 - 2022 U6 - https://doi.org/10.1016/j.labeco.2022.102228 SN - 09275371 VL - 78 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schweigel, Ulrike A1 - Batsios, Petros A1 - Müller-Taubenberger, Annette A1 - Gräf, Ralph A1 - Grafe, Marianne T1 - Dictyostelium spastin is involved in nuclear envelope dynamics during semi-closed mitosis JF - Nucleus N2 - Dictyostelium amoebae perform a semi-closed mitosis, in which the nuclear envelope is fenestrated at the insertion sites of the mitotic centrosomes and around the central spindle during karyokinesis. During late telophase the centrosome relocates to the cytoplasmic side of the nucleus, the central spindle disassembles and the nuclear fenestrae become closed. Our data indicate that Dictyostelium spastin (DdSpastin) is a microtubule-binding and severing type I membrane protein that plays a role in this process. Its mitotic localization is in agreement with a requirement for the removal of microtubules that would hinder closure of the fenestrae. Furthermore, DdSpastin interacts with the HeH/ LEM-family protein Src1 in BioID analyses as well as the inner nuclear membrane protein Sun1, and shows subcellular co-localizations with Src1, Sun1, the ESCRT component CHMP7 and the IST1-like protein filactin, suggesting that the principal pathway of mitotic nuclear envelope remodeling is conserved between animals and Dictyostelium amoebae. KW - Spastin KW - LEM-domain KW - ESCRT KW - sun1 KW - dictyostelium KW - nuclear envelope KW - mitosis Y1 - 2022 U6 - https://doi.org/10.1080/19491034.2022.2047289 SN - 1949-1034 SN - 1949-1042 VL - 13 IS - 1 SP - 144 EP - 154 PB - Taylor & Francis Group CY - Philadelphia ER - TY - JOUR A1 - Azcorra, Hugo A1 - Dickinson, Federico A1 - Mendez-Dominguez, Nina A1 - Mumm, Rebekka A1 - Valentín, Graciela T1 - Development of birthweight and length for gestational age and sex references in Yucatan, Mexico JF - American journal of human biology : the official journal of the Human Biology Council N2 - Objective To develop sex- and gestational age specific reference percentiles and curves for birth weight and length for Yucatec neonates using data from birth registers of infants born during 2015-2019. Material and methods Observational, descriptive, epidemiologic study in a 5-year period including every registered birth in the state of Yucatan, Mexico using birth registries. A total of 158 432 live, physically healthy singletons (76 442 females and 81 990 males) between 25 and 42 weeks of gestation were included in the analysis. We used the LMS method to construct smoothed reference centiles (3rd, 10th, 25th, 50th, 75th, 95th, and 97th) and curves for males and females separately. Results Mean maternal age was 26 (SD = 6.22) years. Fifty-two percent of births occurred by vaginal delivery, 37% were firstborn and similar proportions were second (33%) and third or more (30%) born. 5.5% of newborns included in the references corresponds to neonates born before 37 weeks of gestation (5.9% boys and 5.1% girls). In both sexes, the percentage of infants with a birthweight less than 2500 g was 6.7%. The birthweight at the 50th percentile for males and females at 40 weeks of gestation in this cohort was 3256 and 3167 g, respectively, and the corresponding values for birth length were 50.23 and 49.84 cm (mean differences between sexes: 89 g and 0.40 cm, respectively). Conclusion The reference percentile and curves developed in this study are useful for research purposes and can help health practitioners to assess the biological status of infants born in Yucatan. Y1 - 2022 U6 - https://doi.org/10.1002/ajhb.23732 SN - 1042-0533 SN - 1520-6300 VL - 34 IS - 6 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Bishop, Christopher Allen A1 - Machate, Tina A1 - Henning, Thorsten A1 - Henkel-Oberländer, Janin A1 - Püschel, Gerhard A1 - Weber, Daniela A1 - Grune, Tilman A1 - Klaus, Susanne A1 - Weitkunat, Karolin T1 - Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle JF - Nutrition & Diabetes N2 - Objective: Current data regarding the roles of branched-chain amino acids (BCAA) in metabolic health are rather conflicting, as positive and negative effects have been attributed to their intake. Methods: To address this, individual effects of leucine and valine were elucidated in vivo (C57BL/6JRj mice) with a detailed phenotyping of these supplementations in high-fat (HF) diets and further characterization with in vitro approaches (C2C12 myocytes). Results: Here, we demonstrate that under HF conditions, leucine mediates beneficial effects on adiposity and insulin sensitivity, in part due to increasing energy expenditure-likely contributing partially to the beneficial effects of a higher milk protein intake. On the other hand, valine feeding leads to a worsening of HF-induced health impairments, specifically reducing glucose tolerance/ insulin sensitivity. These negative effects are driven by an accumulation of the valine-derived metabolite 3-hydroxyisobutyrate (3HIB). Higher plasma 3-HIB levels increase basal skeletal muscle glucose uptake which drives glucotoxicity and impairs myocyte insulin signaling. Conclusion: These data demonstrate the detrimental role of valine in an HF context and elucidate additional targetable pathways in the etiology of BCAA-induced obesity and insulin resistance. Y1 - 2022 U6 - https://doi.org/10.1038/s41387-022-00200-8 SN - 2044-4052 VL - 12 IS - 1 PB - Nature Publishing Group CY - London ER - TY - JOUR A1 - Vollbrecht, Joachim A1 - Tokmoldin, Nurlan A1 - Sun, Bowen A1 - Brus, Viktor V. A1 - Shoaee, Safa A1 - Neher, Dieter T1 - Determination of the charge carrier density in organic solar cells BT - a tutorial JF - Journal of applied physics N2 - The increase in the performance of organic solar cells observed over the past few years has reinvigorated the search for a deeper understanding of the loss and extraction processes in this class of device. A detailed knowledge of the density of free charge carriers under different operating conditions and illumination intensities is a prerequisite to quantify the recombination and extraction dynamics. Differential charging techniques are a promising approach to experimentally obtain the charge carrier density under the aforementioned conditions. In particular, the combination of transient photovoltage and photocurrent as well as impedance and capacitance spectroscopy have been successfully used in past studies to determine the charge carrier density of organic solar cells. In this Tutorial, these experimental techniques will be discussed in detail, highlighting fundamental principles, practical considerations, necessary corrections, advantages, drawbacks, and ultimately their limitations. Relevant references introducing more advanced concepts will be provided as well. Therefore, the present Tutorial might act as an introduction and guideline aimed at new prospective users of these techniques as well as a point of reference for more experienced researchers. Published under an exclusive license by AIP Publishing. KW - Electrical properties and parameters KW - Organic semiconductors KW - Solar cells KW - Photoconductivity KW - Capacitance spectroscopy Y1 - 2022 U6 - https://doi.org/10.1063/5.0094955 SN - 0021-8979 SN - 1089-7550 SN - 1520-8850 VL - 131 IS - 22 PB - American Institute of Physics CY - Melville, NY ER - TY - JOUR A1 - Varão Moura, Alexandre A1 - Aparecido Rosini Silva, Alex A1 - Domingos Santo da Silva, José A1 - Aleixo Leal Pedroza, Lucas A1 - Bornhorst, Julia A1 - Stiboller, Michael A1 - Schwerdtle, Tanja A1 - Gubert, Priscila T1 - Determination of ions in Caenorhabditis elegans by ion chromatography JF - Journal of chromatography. B N2 - The Caenorhabditis elegans (C. elegans) is a model organism that has been increasingly used in health and environmental toxicity assessments. The quantification of such elements in vivo can assist in studies that seek to relate the exposure concentration to possible biological effects. Therefore, this study is the first to propose a method of quantitative analysis of 21 ions by ion chromatography (IC), which can be applied in different toxicity studies in C. elegans. The developed method was validated for 12 anionic species (fluoride, acetate, chloride, nitrite, bromide, nitrate, sulfate, oxalate, molybdate, dichromate, phosphate, and perchlorate), and 9 cationic species (lithium, sodium, ammonium, thallium, potassium, magnesium, manganese, calcium, and barium). The method did not present the presence of interfering species, with R2 varying between 0.9991 and 0.9999, with a linear range from 1 to 100 mu g L-1. Limits of detection (LOD) and limits of quantification (LOQ) values ranged from 0.2319 mu g L-1 to 1.7160 mu g L-1 and 0.7028 mu g L-1 to 5.1999 mu g L-1, respectively. The intraday and interday precision tests showed an Relative Standard Deviation (RSD) below 10.0 % and recovery ranging from 71.0 % to 118.0 % with a maximum RSD of 5.5 %. The method was applied to real samples of C. elegans treated with 200 uM of thallium acetate solution, determining the uptake and bioaccumulated Tl+ content during acute exposure. KW - ion chromatography KW - C. elegans KW - method development KW - method validation KW - ion quantification Y1 - 2022 U6 - https://doi.org/10.1016/j.jchromb.2022.123312 SN - 1570-0232 SN - 1873-376X VL - 1204 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Mallonn, Matthias A1 - Poppenhäger, Katja A1 - Granzer, Thomas A1 - Weber, Michael A1 - Strassmeier, Klaus G. T1 - Detection capability of ground-based meter-sized telescopes for shallow exoplanet transits JF - Astronomy and astrophysics : an international weekly journal N2 - Meter-sized ground-based telescopes are frequently used today for the follow-up of extrasolar planet candidates. While the transit signal of a Jupiter-sized object can typically be detected to a high level of confidence with small telescope apertures as well, the shallow transit dips of planets with the size of Neptune and smaller are more challenging to reveal. We employ new observational data to illustrate the photometric follow-up capabilities of meter-sized telescopes for shallow exoplanet transits. We describe in detail the capability of distinguishing the photometric signal of an exoplanet transit from an underlying trend in the light curve. The transit depths of the six targets we observed, Kepler-94b, Kepler-63b, K2-100b, K2-138b, K2-138c, and K2-138e, range from 3.9 ppt down to 0.3 ppt. For five targets of this sample, we provide the first ground-based photometric follow-up. The timing of three targets is precisely known from previous observations, and the timing of the other three targets is uncertain and we aim to constrain it. We detect or rule out the transit features significantly in single observations for the targets that show transits of 1.3 ppt or deeper. The shallower transit depths of two targets of 0.6 and 0.8 ppt were detected tentatively in single light curves, and were detected significantly by repeated observations. Only for the target of the shallowest transit depth of 0.3 ppt were we unable to draw a significant conclusion despite combining five individual light curves. An injection-recovery test on our real data shows that we detect transits of 1.3 ppt depth significantly in single light curves if the transit is fully covered, including out-of-transit data toward both sides, in some cases down to 0.7 ppt depth. For Kepler-94b, Kepler-63b, and K2-100b, we were able to verify the ephemeris. In the case of K2-138c with a 0.6 ppt deep transit, we were able to refine it, and in the case of K2-138e, we ruled out the transit in the time interval of more than ±1.5 σ of its current literature ephemeris. KW - methods: observational KW - techniques: photometric KW - planets and satellites: fundamental parameters Y1 - 2022 U6 - https://doi.org/10.1051/0004-6361/202140599 SN - 0004-6361 SN - 1432-0746 VL - 657 PB - EDP Sciences CY - Les Ulis ER - TY - JOUR A1 - Sposini, Vittoria A1 - Chechkin, Aleksei A1 - Sokolov, Igor M. A1 - Roldan-Vargas, Sandalo T1 - Detecting temporal correlations in hopping dynamics in Lennard-Jones liquids JF - Journal of physics : A, Mathematical and theoretical N2 - Lennard-Jones mixtures represent one of the popular systems for the study of glass-forming liquids. Spatio/temporal heterogeneity and rare (activated) events are at the heart of the slow dynamics typical of these systems. Such slow dynamics is characterised by the development of a plateau in the mean-squared displacement (MSD) at intermediate times, accompanied by a non-Gaussianity in the displacement distribution identified by exponential tails. As pointed out by some recent works, the non-Gaussianity persists at times beyond the MSD plateau, leading to a Brownian yet non-Gaussian regime and thus highlighting once again the relevance of rare events in such systems. Single-particle motion of glass-forming liquids is usually interpreted as an alternation of rattling within the local cage and cage-escape motion and therefore can be described as a sequence of waiting times and jumps. In this work, by using a simple yet robust algorithm, we extract jumps and waiting times from single-particle trajectories obtained via molecular dynamics simulations. We investigate the presence of correlations between waiting times and find negative correlations, which becomes more and more pronounced when lowering the temperature. KW - glassy systems KW - hopping dynamics KW - jump detection KW - rare events Y1 - 2022 U6 - https://doi.org/10.1088/1751-8121/ac7e0a SN - 1751-8113 SN - 1751-8121 VL - 55 IS - 32 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Kitzmann, Niklas H. A1 - Romanczuk, Pawel A1 - Wunderling, Nico A1 - Donges, Jonathan T1 - Detecting contagious spreading of urban innovations on the global city network JF - European physical journal special topics N2 - Only a fast and global transformation towards decarbonization and sustainability can keep the Earth in a civilization-friendly state. As hotspots for (green) innovation and experimentation, cities could play an important role in this transition. They are also known to profit from each other's ideas, with policy and technology innovations spreading to other cities. In this way, cities can be conceptualized as nodes in a globe-spanning learning network. The dynamics of this process are important for society's response to climate change and other challenges, but remain poorly understood on a macroscopic level. In this contribution, we develop an approach to identify whether network-based complex contagion effects are a feature of sustainability policy adoption by cities, based on dose-response contagion and surrogate data models. We apply this methodology to an exemplary data set, comprising empirical data on the spreading of a public transport innovation (Bus Rapid Transit Systems) and a global inter-city connection network based on scheduled flight routes. Although our approach is not able to identify detailed mechanisms, our results point towards a contagious spreading process, and cannot be explained by either the network structure or the increase in global adoption rate alone. Further research on the role of a city's abstract "global neighborhood" regarding its policy and innovation decisions is thus both needed and promising, and may connect with research on social tipping processes. The methodology is generic, and can be used to compare the predictive power for innovation spreading of different kinds of inter-city network connections, e.g. via transport links, trade, or co-membership in political networks. Y1 - 2022 U6 - https://doi.org/10.1140/epjs/s11734-022-00470-4 SN - 1951-6355 SN - 1951-6401 VL - 231 IS - 9 SP - 1609 EP - 1624 PB - Springer CY - Heidelberg ER - TY - JOUR A1 - Zapata-Arteaga, Osnat A1 - Marina, Sara A1 - Zuo, Guangzheng A1 - Xu, Kai A1 - Dörling, Bernhard A1 - Alberto Pérez, Luis A1 - Sebastián Reparaz, Juan A1 - Martín, Jaime A1 - Kemerink, Martijn A1 - Campoy-Quiles, Mariano T1 - Design rules for polymer blends with high thermoelectric performance JF - Advanced energy materials N2 - A combinatorial study of the effect of in-mixing of various guests on the thermoelectric properties of the host workhorse polymer poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene] (PBTTT) is presented. Specifically, the composition and thickness for doped films of PBTTT blended with different polymers are varied. Some blends at guest weight fractions around 10-15% exhibit up to a fivefold increase in power factor compared to the reference material, leading to zT values around 0.1. Spectroscopic analysis of the charge-transfer species, structural characterization using grazing-incidence wide-angle X-ray scattering, differential scanning calorimetry, Raman, and atomic force microscopy, and Monte Carlo simulations are employed to determine that the key to improved performance is for the guest to promote long-range electrical connectivity and low disorder, together with similar highest occupied molecular orbital levels for both materials in order to ensure electronic connectivity are combined. KW - doping KW - microstructure KW - organic thermoelectrics KW - orientation KW - ternary Y1 - 2022 U6 - https://doi.org/10.1002/aenm.202104076 SN - 1614-6832 SN - 1614-6840 VL - 12 IS - 19 PB - Wiley CY - Weinheim ER - TY - JOUR A1 - Sagu Tchewonpi, Sorel A1 - Huschek, Gerd A1 - Waldbach Braga, Tess A1 - Rackiewicz, Michal A1 - Homann, Thomas A1 - Rawel, Harshadrai Manilal T1 - Design of Experiment (DoE) for Optimization of HPLC Conditions for the Simultaneous Fractionation of Seven α-Amylase/Trypsin Inhibitors from Wheat (Triticum aestivum L.) JF - Processes : open access journal N2 - Wheat alpha-amylase/trypsin inhibitors remain a subject of interest considering the latest findings showing their implication in wheat-related non-celiac sensitivity (NCWS). Understanding their functions in such a disorder is still unclear and for further study, the need for pure ATI molecules is one of the limiting problems. In this work, a simplified approach based on the successive fractionation of ATI extracts by reverse phase and ion exchange chromatography was developed. ATIs were first extracted from wheat flour using a combination of Tris buffer and chloroform/methanol methods. The separation of the extracts on a C18 column generated two main fractions of interest F1 and F2. The response surface methodology with the Doehlert design allowed optimizing the operating parameters of the strong anion exchange chromatography. Finally, the seven major wheat ATIs namely P01083, P17314, P16850, P01085, P16851, P16159, and P83207 were recovered with purity levels (according to the targeted LC-MS/MS analysis) of 98.2 ± 0.7; 98.1 ± 0.8; 97.9 ± 0.5; 95.1 ± 0.8; 98.3 ± 0.4; 96.9 ± 0.5, and 96.2 ± 0.4%, respectively. MALDI-TOF-MS analysis revealed single peaks in each of the pure fractions and the mass analysis yielded deviations of 0.4, 1.9, 0.1, 0.2, 0.2, 0.9, and 0.1% between the theoretical and the determined masses of P01083, P17314, P16850, P01085, P16851, P16159, and P83207, respectively. Overall, the study allowed establishing an efficient purification process of the most important wheat ATIs. This paves the way for further in-depth investigation of the ATIs to gain more knowledge related to their involvement in NCWS disease and to allow the absolute quantification in wheat samples. KW - wheat KW - α-amylase/trypsin inhibitors KW - fractionation KW - purification KW - reversed-phase chromatography KW - ion-exchange chromatography KW - design of experiment KW - LC–MS/MS KW - MALDI-TOF-MS Y1 - 2022 U6 - https://doi.org/10.3390/pr10020259 SN - 2227-9717 VL - 10 SP - 1 EP - 18 PB - MDPI CY - Basel, Schweiz ET - 2 ER - TY - JOUR A1 - Sauter, Tilman A1 - Kratz, Karl A1 - Farhan, Muhammad A1 - Heuchel, Matthias A1 - Lendlein, Andreas T1 - Design and fabrication of fiber mesh actuators JF - Applied materials today N2 - Soft actuator performance can be tuned by chemistry or mechanical manipulation, but this adjustability is limited especially in view of their growing technological relevance. Inspired from textile engineering, we designed and fabricated fiber mesh actuators and introduced new features like anisotropic behavior and soft-tissue like elastic deformability. Design criteria for the meshes are the formation of fiber bundles, the angle between fiber bundles in different stacked layers and covalent crosslinks forming within and between fibers at their interfacial contact areas. Through crosslinking the interfiber bond strength increased from a bond transmitting neither axial nor rotational loads (pin joint) to a bond strength capable of both (welded joint). For non-linear elastic stiffening, stacked fiber bundles with four embracing fibers were created forming microstructural rhombus shapes. Loading the rhombus diagonally allowed generation of “soft tissue”-like mechanics. By adjustment of stacking angles, the point of strong increase in stress is tuned. While the highest stresses are observed in aligned and crosslinked fiber mats along the direction of the fiber, the strongest shape-memory actuation behavior is found in randomly oriented fiber mats. Fiber mesh actuators controlled by temperature are of high significance as soft robot skins and as for active patches supporting tissue regeneration. Y1 - 2022 U6 - https://doi.org/10.1016/j.apmt.2022.101562 SN - 2352-9407 VL - 29 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Marco Figuera, Ramiro A1 - Riedel, Christian A1 - Rossi, Angelo Pio A1 - Unnithan, Vikram T1 - Depth to diameter analysis on small simple craters at the lunar south pole - possible implications for ice harboring JF - Remote sensing N2 - In this paper, we present a study comparing the depth to diameter (d/D) ratio of small simple craters (200-1000 m) of an area between -88.5 degrees to -90 degrees latitude at the lunar south pole containing Permanent Shadowed Regions (PSRs) versus craters without PSRs. As PSRs can reach temperatures of 110 K and are capable of harboring volatiles, especially water ice, we analyzed the relationship of depth versus diameter ratios and its possible implications for harboring water ice. Variations in the d/D ratios can also be caused by other processes such as degradation, isostatic adjustment, or differences in surface properties. The conducted d/D ratio analysis suggests that a differentiation between craters containing PSRs versus craters without PSRs occurs. Thus, a possible direct relation between d/D ratio, PSRs, and water ice harboring might exist. Our results suggest that differences in the target's surface properties may explain the obtained results. The resulting d/D ratios of craters with PSRs can help to select target areas for future In-Situ Resource Utilization (ISRU) missions. KW - craters KW - lunar exploration KW - ice harboring Y1 - 2022 U6 - https://doi.org/10.3390/rs14030450 SN - 2072-4292 VL - 14 IS - 3 PB - MDPI CY - Basel ER - TY - JOUR A1 - Drozdov, Alexander A1 - Allison, Hayley J. A1 - Shprits, Yuri Y. A1 - Usanova, Maria E. A1 - Saikin, Anthony A1 - Wang, Dedong T1 - Depletions of Multi-MeV Electrons and their association to Minima in Phase Space Density JF - Geophysical research letters N2 - Fast-localized electron loss, resulting from interactions with electromagnetic ion cyclotron (EMIC) waves, can produce deepening minima in phase space density (PSD) radial profiles. Here, we perform a statistical analysis of local PSD minima to quantify how readily these are associated with radiation belt depletions. The statistics of PSD minima observed over a year are compared to the Versatile Electron Radiation Belts (VERB) simulations, both including and excluding EMIC waves. The observed minima distribution can only be achieved in the simulation including EMIC waves, indicating their importance in the dynamics of the radiation belts. By analyzing electron flux depletions in conjunction with the observed PSD minima, we show that, in the heart of the outer radiation belt (L* < 5), on average, 53% of multi-MeV electron depletions are associated with PSD minima, demonstrating that fast localized loss by interactions with EMIC waves are a common and crucial process for ultra-relativistic electron populations. KW - radiation belts KW - EMIC KW - VERB KW - PSD Y1 - 2022 U6 - https://doi.org/10.1029/2021GL097620 SN - 0094-8276 SN - 1944-8007 VL - 49 IS - 8 PB - American Geophysical Union CY - Washington ER - TY - JOUR A1 - Boeker, Sonja A1 - Hermanussen, Michael A1 - Scheffler, Christiane T1 - Dental age is an independent marker of biological age JF - Human biology and public health N2 - Background: Biological age markers are a crucial indicator whether children are decelerated in growth tempo. Skeletal maturation is the standard measure. Yet, it relies on exposing children to x-radiation. Dental eruption is a potential, but highly debated, radiation free alternative.  Objectives: We assess the interrelationship between dental eruption and other maturational markers. We hypothesize that dental age correlates with body height and skeletal age. We further evaluate how the three different variables behave in cohorts from differing social backgrounds. Sample and Method: Dental, skeletal and height data from the 1970s to 1990s from Guatemalan boys were converted into standard deviation scores, using external references for each measurement. The boys, aged between 7 and 12, derived from different social backgrounds (middle SES (N = 6529), low-middle SES (N = 736), low SES Ladino (N = 3653) and low SES Maya (N = 4587). Results: Dental age shows only a weak correlation with skeletal age (0.18) and height (0.2). The distinction between cohorts differs according to each of the three measurements. All cohorts differ significantly in height. In skeletal maturation, the middle SES cohort is significantly advanced compared to all other cohorts. The periodically malnourished cohorts of low SES Mayas and Ladinos are significantly delayed in dental maturation compared to the well-nourished low-middle and middle class Ladino children. Conclusion: Dental development is an independent system, that is regulated by different mechanisms than skeletal development and growth. Tooth eruption is sensitive to nutritional status, whereas skeletal age is more sensitive to socioeconomic background. KW - dental eruption KW - biological age KW - skeletal age KW - growth tempo KW - maturation KW - malnutrition Y1 - 2022 U6 - https://doi.org/10.52905/hbph2021.3.24 SN - 2748-9957 VL - 2021 IS - 3, Summer School Supplement PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schmidt-Wellenburg, Christian T1 - Democratization or politicization? BT - The changing face of political-economic expertide in European expert groups, 1966-2017 JF - The condition of democracy : Volume 1: Neoliberal politics and sociological perspectives Y1 - 2022 SN - 978-1-00-040191-2 SN - 978-1-00-315836-3 SP - 106 EP - 128 PB - Routledge CY - London ER - TY - JOUR A1 - Tolomeev, Aleksandr P. A1 - Dubovskaya, Olga P. A1 - Kirillin, Georgiy A1 - Buseva, Zhanna A1 - Kolmakova, Olesya A1 - Grossart, Hans-Peter A1 - Tang, Kam W. A1 - Gladyšev, Michail I. T1 - Degradation of dead cladoceran zooplankton and their contribution to organic carbon cycling in stratified lakes BT - field observation and model prediction JF - Journal of plankton research N2 - The contribution of dead zooplankton biomass to carbon cycle in aquatic ecosystems is practically unknown. Using abundance data of zooplankton in water column and dead zooplankton in sediment traps in Lake Stechlin, an ecological-mathematical model was developed to simulate the abundance and sinking of zooplankton carcasses and predict the related release of labile organic matter (LOM) into the water column. We found species-specific differences in mortality rate of the dominant zooplankton: Daphnia cucullata, Bosmina coregoni and Diaphanosoma brachyurum (0.008, 0.129 and 0.020 day(-1), respectively) and differences in their carcass sinking velocities in metalimnion (and hypolimnion): 2.1 (7.64), 14.0 (19.5) and 1.1 (5.9) m day(-1), respectively. Our model simulating formation and degradation processes of dead zooplankton predicted a bimodal distribution of the released LOM: epilimnic and metalimnic peaks of comparable intensity, ca. 1 mg DW m(-3) day(-1). Maximum degradation of carcasses up to ca. 1.7 mg DW m(-3) day(-1) occurred in the density gradient zone of metalimnion. LOM released from zooplankton carcasses into the surrounding water may stimulate microbial activity and facilitate microbial degradation of more refractory organic matter; therefore, dead zooplankton are expected to be an integral part of water column carbon source/sink dynamics in stratified lakes. KW - zooplankton carcasses KW - non-predatory mortality KW - sinking velocities KW - microbial degradation KW - Lake Stechlin KW - simulation modeling Y1 - 2022 U6 - https://doi.org/10.1093/plankt/fbac023 SN - 0142-7873 SN - 1464-3774 VL - 44 IS - 3 SP - 386 EP - 400 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Bonetto, Riccardo A1 - Pound, Adam A1 - Sam, Zeyd T1 - Deformed Schwarzschild horizons in second-order perturbation theory BT - mass, geometry, and teleology JF - Physical review D, Particles, fields, gravitation, and cosmology N2 - In recent years, gravitational-wave astronomy has motivated increasingly accurate perturbative studies of gravitational dynamics in compact binaries. This in turn has enabled more detailed analyses of the dynamical black holes in these systems. For example, Pound et al. [Phys. Rev. Lett. 124, 021101 (2020)] recently computed the surface area of a Schwarzschild black hole's apparent horizon, perturbed by an orbiting body, to second order in the binary's mass ratio. In this paper, we take that as the starting point for a comprehensive study of a perturbed Schwarzschild black hole's apparent and event horizon at second perturbative order, deriving generic formulas for the first- and second-order corrections to the horizons' radial profiles, surface areas, Hawking masses, and intrinsic curvatures. We find that the two horizons are remarkably similar, and that any teleological behavior of the event horizon is suppressed in several ways. Critically, we establish that at all orders, the perturbed event horizon in a small-mass-ratio binary is effectively localized in time. Even more pointedly, the event horizon is identical to the apparent horizon at linear order regardless of the source of perturbation, implying that the seemingly teleological "tidal lead," previously observed in linearly perturbed event horizons, is not genuinely teleological in origin. The two horizons do generically differ at second order, but their Hawking masses remain identical, implying that the event horizon obeys the same energy-flux balance law as the apparent horizon. At least in the case of a binary system, the difference between their surface areas remains extremely small even in the late stages of inspiral. In the course of our analysis, we also numerically illustrate puzzling behavior in the black hole's motion around the binary's center of mass. Y1 - 2022 U6 - https://doi.org/10.1103/PhysRevD.105.024048 SN - 2470-0010 SN - 2470-0029 VL - 105 IS - 2 PB - American Physical Society CY - College Park ER -