TY  - JOUR
A1  - Koeth, Anja
A1  - Tiersch, Brigitte
A1  - Appelhans, Dietmar
A1  - Gradzielski, Michael
A1  - Cölfen, Helmut
A1  - Koetz, Joachim
T1  - Synthesis of Core-Shell Gold Nanoparticles with Maltose-Modified Poly(Ethyleneimine)
JF  - Journal of dispersion science and technology
N2  - The synthesis of ultrafine gold nanoparticles in presence of maltose-modified hyperbranched poly(ethyleneimines) (PEI) is described. The polymer acted as both a reducing and stabilising agent in the particle formation process. The nanoparticles were characterized by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), analytical ultracentrifugation (AUC), small-angle x-ray scattering (SAXS), and small-angle neutron scattering (SANS). The mechanism of nanoparticle formation can be described in two steps. The reduction process of the Au3+ ions located in the inner coil region of the hyperbranched PEI led to the formation of a compact gold core, and is accompanied by a collapse of the polymer coil. Therefore, in the subsequent reduction process a gold-polymer hybrid shell is formed. By using the PEI of higher molar mass, core-shell gold nanoparticles of about 3.6 nm size with a more narrow size distribution and special fluorescence behavior could be synthesized.
KW  - Gold nanoparticles
KW  - gold-polymer hybrid shell
KW  - maltose-modified poly(ethyleneimine)
Y1  - 2012
U6  - https://doi.org/10.1080/01932691.2010.530084
SN  - 0193-2691
VL  - 33
IS  - 1-3
SP  - 52
EP  - 60
PB  - Taylor & Francis Group
CY  - Philadelphia
ER  - 
TY  - JOUR
A1  - Rumschoettel, Jens
A1  - Kosmella, Sabine
A1  - Prietzel, Claudia Christina
A1  - Appelhans, Dietmar
A1  - Koetz, Joachim
T1  - DNA polyplexes with dendritic glycopolymer-entrapped gold nanoparticles
JF  - Colloids and surfaces : an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin ; B, Biointerfaces
N2  - Polyplexes, composed of Salmon DNA and very small gold nanoparticles embedded into a dendritic glycopolymer architecture of sugar-modified poly(ethyleneimine) (PEI-Mal) with a molar mass of about 25,000 g/mol, were characterized by dynamic light scattering (DLS), zeta potential measurements, micro differential scanning calorimetry (mu-DSC) and transmission electron microscopy (TEM). The PEI-Mal-entrapped gold nanoparticles of about 2 nm in diameter influence the polyplex formation of the hyperbranched PEI containing bulky maltose, and in consequence the DNA is more compactized in the inner part of spherical polyplex particles of about 150 nm in diameter. The resulting more compact core shell polyplex particles with embedded gold nanoparticles in the outer polymer shell will be used as components in forthcoming gene delivery experiments. (C) 2017 Elsevier B.V. All rights reserved.
KW  - DNA polyplexes
KW  - Gold nanoparticles
KW  - Maltose-modified poly(ethyleneimine)
KW  - TEM
KW  - mu-DSC
Y1  - 2017
U6  - https://doi.org/10.1016/j.colsurfb.2017.03.001
SN  - 0927-7765
SN  - 1873-4367
VL  - 154
SP  - 74
EP  - 81
PB  - Elsevier
CY  - Amsterdam
ER  -