TY  - JOUR
A1  - Gryzik, Stefanie
A1  - Hoang, Yen
A1  - Lischke, Timo
A1  - Mohr, Elodie
A1  - Venzke, Melanie
A1  - Kadner, Isabelle
A1  - Pötzsch, Josephine
A1  - Groth, Detlef
A1  - Radbruch, Andreas
A1  - Hutloff, Andreas
A1  - Baumgrass, Ria
T1  - Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception
JF  - eLife
N2  - Dysregulated cytokine expression by T cells plays a pivotal role in the pathogenesis of autoimmune diseases. However, the identification of the corresponding pathogenic subpopulations is a challenge, since a distinction between physiological variation and a new quality in the expression of protein markers requires combinatorial evaluation. Here, we were able to identify a super-functional follicular helper T cell (Tfh)-like subpopulation in lupus-prone NZBxW mice with our binning approach "pattern recognition of immune cells (PRI)". PRI uncovered a subpopulation of IL-21(+) IFN-gamma(high) PD-1(low) CD40L(high) CXCR5(-) Bcl-6(-) T cells specifically expanded in diseased mice. In addition, these cells express high levels of TNF-alpha and IL-2, and provide B cell help for IgG production in an IL-21 and CD40L dependent manner. This super-functional T cell subset might be a superior driver of autoimmune processes due to a polyfunctional and high cytokine expression combined with Tfh-like properties.
Y1  - 2020
U6  - https://doi.org/10.7554/eLife.53226
SN  - 2050-084X
VL  - 9
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -